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Добірка наукової літератури з теми "004.891:004.82 (045)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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Статті в журналах з теми "004.891:004.82 (045)"

1

Luangtrakool, Panpimon, Sasijit Vejbaesya, Komon Luangtrakool, et al. "Major Histocompatibility Complex Class I Chain–Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais." Journal of Infectious Diseases 222, no. 5 (2020): 840–46. http://dx.doi.org/10.1093/infdis/jiaa134.

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Abstract Background Major histocompatibility complex class I chain–related (MIC) A and B (MICA and MICB) are polymorphic stress molecules recognized by natural killer cells. This study was performed to analyze MIC gene profiles in hospitalized Thai children with acute dengue illness. Methods MIC allele profiles were determined in a discovery cohort of patients with dengue fever or dengue hemorrhagic fever (DHF) (n = 166) and controls (n = 149). A replication cohort of patients with dengue (n = 222) was used to confirm specific MICB associations with disease. Results MICA*045 and MICB*004 assoc

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2

Clarke, Janet T., Sue E. Moore, and Donald K. Ljungblad. "Observations on gray whale (Eschrichtius robustus) utilization patterns in the northeastern Chukchi Sea, July–October 1982–1987." Canadian Journal of Zoology 67, no. 11 (1989): 2646–54. http://dx.doi.org/10.1139/z89-374.

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A total of 821 gray whales were seen during aerial surveys in the northeastern Chukchi Sea from July through October 1982–1987. Gray whale distribution extended from south of Point Hope to northeast of Point Barrow, Alaska, between 0.5 and 166 km offshore. Monthly abundance estimates (number of whales/survey hour) were highest in July (6.81) and lowest in October (0.40). Gray whales were usually in open water (82%, n = 670) or in light ice (16%, n = 134) and were seldom associated with heavy ice (2%, n = 17). Most whales were feeding (63%, n = 514), with the majority of the others swimming and

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3

Pierce, Gary L., Darren P. Casey, Jess G. Fiedorowicz, et al. "Aortic pulse wave velocity and reflecting distance estimation from peripheral waveforms in humans: detection of age- and exercise training-related differences." American Journal of Physiology-Heart and Circulatory Physiology 305, no. 1 (2013): H135—H142. http://dx.doi.org/10.1152/ajpheart.00916.2012.

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We hypothesized that demographic/anthropometric parameters can be used to estimate effective reflecting distance (EfRD), required to derive aortic pulse wave velocity (APWV), a prognostic marker of cardiovascular risk, from peripheral waveforms and that such estimates can discriminate differences in APWV and EfRD with aging and habitual endurance exercise in healthy adults. Ascending aortic pressure waveforms were derived from peripheral waveforms (brachial artery pressure, n = 25; and finger volume pulse, n = 15) via a transfer function and then used to determine the time delay between forwar

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4

Rojas, Carlos, Ferry Eskens, François Ghiringhelli, et al. "Vibostolimab coformulated with pembrolizumab (vibo/pembro) for previously treated advanced mismatch repair–deficient (dMMR) endometrial cancer: Results from cohort B1 of the phase 2 KEYVIBE-005 study." Journal of Clinical Oncology 42, no. 16_suppl (2024): 5502. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.5502.

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5502 Background: Treatment options for advanced endometrial cancer after failure of first-line chemotherapy are limited. In the KEYNOTE-158 study, pembro demonstrated durable antitumor activity (ORR, 48%; median DOR, not reached [NR]; median PFS, 13.1 mo; median OS, NR) and an acceptable safety profile in patients (pts) with previously treated advanced microsatellite instability-high/dMMR endometrial cancer. The immune checkpoints TIGIT and PD-L1 are upregulated in several tumor types, including endometrial cancer, and are heavily coexpressed in dMMR tumors, suggesting that dual TIGIT/PD-(L)1

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5

Brodsky, Sergey, Lee Hebert, Haifeng Wu, et al. "Increased INR>3.0 In Patients on Warfarin Therapy Is Associated with Acute Changes In the Serum Creatinine and Increased Mortality Rate." Blood 116, no. 21 (2010): 819. http://dx.doi.org/10.1182/blood.v116.21.819.819.

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Abstract Abstract 819 Recently we reported that an excessive anticoagulation with warfarin (INR>3.0) can result in acute kidney injury (AKI). Morphologic findings included glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts. The clinical outcome in these patients was unfavorable; more than half of them did not recover from acute kidney injury even after normalization of INR. Later we analyzed serum creatinine (SC) and INR in patients with chronic kidney disease (CKD) on warfarin therapy. We found that 46% of patients had increase in SC levels >0.3 mg/dl asso

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6

Pennock, Andrew T., James D. Bomar, Kristina P. Johnson, Kelly Randich, and Vidyadhar V. Upasani. "Nonoperative Management of Femoroacetabular Impingement: A Prospective Study." American Journal of Sports Medicine 46, no. 14 (2018): 3415–22. http://dx.doi.org/10.1177/0363546518804805.

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Background: The literature has given little attention to the nonoperative management of femoroacetabular impingement (FAI) syndrome despite a rapidly expanding body of research on the topic. Purpose: To perform a prospective study utilizing a nonoperative protocol on a consecutive series of patients presenting to our clinic with FAI syndrome. Study Design: Cohort study; Level of evidence, 2. Methods: Between 2013 and 2016, patients meeting the following criteria were prospectively recruited in a nonoperative FAI study: no prior hip surgery, groin-based pain, a positive impingement test, and ra

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7

Qiu, Jianhui, Jingcheng Zhou, Lin Cai, et al. "Belzutifan monotherapy in Chinese patients (pts) with von Hippel-Lindau (VHL) disease–associated tumors: Results of LITESPARK-015 study." Journal of Clinical Oncology 43, no. 5_suppl (2025): 534. https://doi.org/10.1200/jco.2025.43.5_suppl.534.

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534 Background: Pts with VHL disease are at risk of developing malignant tumors such as renal cell carcinoma (RCC) due to VHL gene inactivation, leading to activation of hypoxia-inducible factors (HIFs). In the phase 2 LITESPARK-004 study, HIF-2α inhibitor belzutifan (MK-6482) demonstrated antitumor activity and a manageable safety profile in pts with VHL disease–associated tumors; however, the study did not include pts from Asia. We present results for pts from mainland China with VHL disease–associated localized tumors enrolled in cohort B1 of the phase 2, open-label, single-arm LITESPARK-01

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8

Mandel, Philipp, Benedikt Hoeh, Carolin Siech, et al. "Lutetium-177 PSMA radioligand therapy in taxan-naive first- and second-line metastatic castration resistant prostate cancer after first-line ARPI therapy." Journal of Clinical Oncology 43, no. 5_suppl (2025): 79. https://doi.org/10.1200/jco.2025.43.5_suppl.79.

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79 Background: Lutetium-177 Prostate-specific membrane antigen (Lu-PSMA) radioligand therapy is EMA-approved for metastatic castration resistant prostate cancer (mCRPC) after androgen receptor pathway inhibition (ARPI) and taxane-based chemotherapy. However, its effect in taxane-naïve patients is under current investigation. Methods: We relied on the FRAMCAP database to elaborate Lu-PSMA therapy outcomes of progression-free (PFS) and overall (OS) in taxane-naïve mCRPC patients after previous ARPI treatment. Comparison was made against current standard of care with ARPI or docetaxel. Results: O

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9

Babl, Franz, David Herd, Meredith Borland, et al. "1396 Prednisolone for Bell’s Palsy in children: A randomised, double-blind, placebo-controlled, Multicentre Trial." Emergency Medicine Journal 39, no. 12 (2022): A967. http://dx.doi.org/10.1136/emermed-2022-rcem2.9.

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Aims, Objectives and BackgroundCorticosteroids can be used to treat idiopathic facial paralysis (Bell’s palsy) in children, but their effectiveness is uncertain.AimsTo determine if prednisolone improves recovery of children with Bell’s palsy at one month.Method and DesignDouble-blind, placebo-controlled, randomised, trial of prednisolone in children presenting to ED with Bell’s palsy.1Patients 6 months to <18 years, recruited <72 hours after symptom onset, were randomly assigned to receive 10 days of treatment with oral prednisolone (1 mg/kg) or placebo. The primary outcome: complete rec

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10

Chino, Fumiko, Amy L. Tin, Emeline Mariam Aviki, and Bridgette Thom. "Longitudinal outcomes after financial toxicity and health-related social risks screening and referral." JCO Oncology Practice 20, no. 10_suppl (2024): 17. http://dx.doi.org/10.1200/op.2024.20.10_suppl.17.

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17 Background: Financial toxicity (FT) is associated with delayed/omitted care, reduced quality of life, and worse mortality. Routine screening for FT and health-related social risks (HRSR) is recommended during clinical care, but there is limited longitudinal evidence on outcomes after patients screen positive and are referred for assistance. Methods: FT and HRSR screening for patients with breast, gynecologic, gastrointestinal, or thoracic cancers was implemented at an urban comprehensive cancer center. Screening included the Comprehensive Score for Financial Toxicity (COST) tool (0-44, lowe

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