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Статті в журналах з теми "004.891:004.82 (045)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Luangtrakool, Panpimon, Sasijit Vejbaesya, Komon Luangtrakool, et al. "Major Histocompatibility Complex Class I Chain–Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais." Journal of Infectious Diseases 222, no. 5 (2020): 840–46. http://dx.doi.org/10.1093/infdis/jiaa134.

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Abstract Background Major histocompatibility complex class I chain–related (MIC) A and B (MICA and MICB) are polymorphic stress molecules recognized by natural killer cells. This study was performed to analyze MIC gene profiles in hospitalized Thai children with acute dengue illness. Methods MIC allele profiles were determined in a discovery cohort of patients with dengue fever or dengue hemorrhagic fever (DHF) (n = 166) and controls (n = 149). A replication cohort of patients with dengue (n = 222) was used to confirm specific MICB associations with disease. Results MICA*045 and MICB*004 assoc

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2

Clarke, Janet T., Sue E. Moore, and Donald K. Ljungblad. "Observations on gray whale (Eschrichtius robustus) utilization patterns in the northeastern Chukchi Sea, July–October 1982–1987." Canadian Journal of Zoology 67, no. 11 (1989): 2646–54. http://dx.doi.org/10.1139/z89-374.

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A total of 821 gray whales were seen during aerial surveys in the northeastern Chukchi Sea from July through October 1982–1987. Gray whale distribution extended from south of Point Hope to northeast of Point Barrow, Alaska, between 0.5 and 166 km offshore. Monthly abundance estimates (number of whales/survey hour) were highest in July (6.81) and lowest in October (0.40). Gray whales were usually in open water (82%, n = 670) or in light ice (16%, n = 134) and were seldom associated with heavy ice (2%, n = 17). Most whales were feeding (63%, n = 514), with the majority of the others swimming and

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3

Pierce, Gary L., Darren P. Casey, Jess G. Fiedorowicz, et al. "Aortic pulse wave velocity and reflecting distance estimation from peripheral waveforms in humans: detection of age- and exercise training-related differences." American Journal of Physiology-Heart and Circulatory Physiology 305, no. 1 (2013): H135—H142. http://dx.doi.org/10.1152/ajpheart.00916.2012.

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We hypothesized that demographic/anthropometric parameters can be used to estimate effective reflecting distance (EfRD), required to derive aortic pulse wave velocity (APWV), a prognostic marker of cardiovascular risk, from peripheral waveforms and that such estimates can discriminate differences in APWV and EfRD with aging and habitual endurance exercise in healthy adults. Ascending aortic pressure waveforms were derived from peripheral waveforms (brachial artery pressure, n = 25; and finger volume pulse, n = 15) via a transfer function and then used to determine the time delay between forwar

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4

Rojas, Carlos, Ferry Eskens, François Ghiringhelli, et al. "Vibostolimab coformulated with pembrolizumab (vibo/pembro) for previously treated advanced mismatch repair–deficient (dMMR) endometrial cancer: Results from cohort B1 of the phase 2 KEYVIBE-005 study." Journal of Clinical Oncology 42, no. 16_suppl (2024): 5502. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.5502.

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5502 Background: Treatment options for advanced endometrial cancer after failure of first-line chemotherapy are limited. In the KEYNOTE-158 study, pembro demonstrated durable antitumor activity (ORR, 48%; median DOR, not reached [NR]; median PFS, 13.1 mo; median OS, NR) and an acceptable safety profile in patients (pts) with previously treated advanced microsatellite instability-high/dMMR endometrial cancer. The immune checkpoints TIGIT and PD-L1 are upregulated in several tumor types, including endometrial cancer, and are heavily coexpressed in dMMR tumors, suggesting that dual TIGIT/PD-(L)1

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5

Brodsky, Sergey, Lee Hebert, Haifeng Wu, et al. "Increased INR>3.0 In Patients on Warfarin Therapy Is Associated with Acute Changes In the Serum Creatinine and Increased Mortality Rate." Blood 116, no. 21 (2010): 819. http://dx.doi.org/10.1182/blood.v116.21.819.819.

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Abstract Abstract 819 Recently we reported that an excessive anticoagulation with warfarin (INR>3.0) can result in acute kidney injury (AKI). Morphologic findings included glomerular hemorrhage and renal tubular obstruction by red blood cell (RBC) casts. The clinical outcome in these patients was unfavorable; more than half of them did not recover from acute kidney injury even after normalization of INR. Later we analyzed serum creatinine (SC) and INR in patients with chronic kidney disease (CKD) on warfarin therapy. We found that 46% of patients had increase in SC levels >0.3 mg/dl asso

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6

Pennock, Andrew T., James D. Bomar, Kristina P. Johnson, Kelly Randich, and Vidyadhar V. Upasani. "Nonoperative Management of Femoroacetabular Impingement: A Prospective Study." American Journal of Sports Medicine 46, no. 14 (2018): 3415–22. http://dx.doi.org/10.1177/0363546518804805.

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Background: The literature has given little attention to the nonoperative management of femoroacetabular impingement (FAI) syndrome despite a rapidly expanding body of research on the topic. Purpose: To perform a prospective study utilizing a nonoperative protocol on a consecutive series of patients presenting to our clinic with FAI syndrome. Study Design: Cohort study; Level of evidence, 2. Methods: Between 2013 and 2016, patients meeting the following criteria were prospectively recruited in a nonoperative FAI study: no prior hip surgery, groin-based pain, a positive impingement test, and ra

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7

Qiu, Jianhui, Jingcheng Zhou, Lin Cai, et al. "Belzutifan monotherapy in Chinese patients (pts) with von Hippel-Lindau (VHL) disease–associated tumors: Results of LITESPARK-015 study." Journal of Clinical Oncology 43, no. 5_suppl (2025): 534. https://doi.org/10.1200/jco.2025.43.5_suppl.534.

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534 Background: Pts with VHL disease are at risk of developing malignant tumors such as renal cell carcinoma (RCC) due to VHL gene inactivation, leading to activation of hypoxia-inducible factors (HIFs). In the phase 2 LITESPARK-004 study, HIF-2α inhibitor belzutifan (MK-6482) demonstrated antitumor activity and a manageable safety profile in pts with VHL disease–associated tumors; however, the study did not include pts from Asia. We present results for pts from mainland China with VHL disease–associated localized tumors enrolled in cohort B1 of the phase 2, open-label, single-arm LITESPARK-01

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8

Mandel, Philipp, Benedikt Hoeh, Carolin Siech, et al. "Lutetium-177 PSMA radioligand therapy in taxan-naive first- and second-line metastatic castration resistant prostate cancer after first-line ARPI therapy." Journal of Clinical Oncology 43, no. 5_suppl (2025): 79. https://doi.org/10.1200/jco.2025.43.5_suppl.79.

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79 Background: Lutetium-177 Prostate-specific membrane antigen (Lu-PSMA) radioligand therapy is EMA-approved for metastatic castration resistant prostate cancer (mCRPC) after androgen receptor pathway inhibition (ARPI) and taxane-based chemotherapy. However, its effect in taxane-naïve patients is under current investigation. Methods: We relied on the FRAMCAP database to elaborate Lu-PSMA therapy outcomes of progression-free (PFS) and overall (OS) in taxane-naïve mCRPC patients after previous ARPI treatment. Comparison was made against current standard of care with ARPI or docetaxel. Results: O

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9

Babl, Franz, David Herd, Meredith Borland, et al. "1396 Prednisolone for Bell’s Palsy in children: A randomised, double-blind, placebo-controlled, Multicentre Trial." Emergency Medicine Journal 39, no. 12 (2022): A967. http://dx.doi.org/10.1136/emermed-2022-rcem2.9.

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Aims, Objectives and BackgroundCorticosteroids can be used to treat idiopathic facial paralysis (Bell’s palsy) in children, but their effectiveness is uncertain.AimsTo determine if prednisolone improves recovery of children with Bell’s palsy at one month.Method and DesignDouble-blind, placebo-controlled, randomised, trial of prednisolone in children presenting to ED with Bell’s palsy.1Patients 6 months to <18 years, recruited <72 hours after symptom onset, were randomly assigned to receive 10 days of treatment with oral prednisolone (1 mg/kg) or placebo. The primary outcome: complete rec

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10

Chino, Fumiko, Amy L. Tin, Emeline Mariam Aviki, and Bridgette Thom. "Longitudinal outcomes after financial toxicity and health-related social risks screening and referral." JCO Oncology Practice 20, no. 10_suppl (2024): 17. http://dx.doi.org/10.1200/op.2024.20.10_suppl.17.

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17 Background: Financial toxicity (FT) is associated with delayed/omitted care, reduced quality of life, and worse mortality. Routine screening for FT and health-related social risks (HRSR) is recommended during clinical care, but there is limited longitudinal evidence on outcomes after patients screen positive and are referred for assistance. Methods: FT and HRSR screening for patients with breast, gynecologic, gastrointestinal, or thoracic cancers was implemented at an urban comprehensive cancer center. Screening included the Comprehensive Score for Financial Toxicity (COST) tool (0-44, lowe

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11

Karam, Dhauna, Robert A. Vierkant, Shawna Ehlers, et al. "Abstract 5262: Physical function, mental health, and overall health of older breast cancer survivors." Cancer Research 82, no. 12_Supplement (2022): 5262. http://dx.doi.org/10.1158/1538-7445.am2022-5262.

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Abstract Introduction: Patients at extremes of age may be particularly vulnerable to poor physical and mental health after treatment for breast cancer; we examined factors associated with poor health in older breast cancer survivors. Methods: The Mayo Clinic Breast Disease Registry (MCBDR) is a prospective longitudinal cohort study that enrolls Mayo Clinic Rochester patients diagnosed with stage 0-4 breast cancer (BC). In 2020, we mailed a survey to 1,273 MCBDR participants aged 77+. Three PROMIS-10 items were used to assess overall health, mental health, and physical function. Self-reported c

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12

Di Sario, A., G. S. Baroni, E. Bendia, et al. "Characterization of ion transport mechanisms regulating intracellular pH in hepatic stellate cells." American Journal of Physiology-Gastrointestinal and Liver Physiology 273, no. 1 (1997): G39—G48. http://dx.doi.org/10.1152/ajpgi.1997.273.1.g39.

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The aim of this study was to evaluate intracellular pH (pHi) regulation in nonactivated and activated rat hepatic stellate cells (HSC). The fluorescent pHi indicator 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein was used to measure pHi in the presence and absence of HCO3-. In the absence of HCO3-, baseline pHi was significantly higher (P < 0.001) in activated than in nonactivated HSC (7.1 +/- 0.1 vs. 6.9 +/- 0.2) and decreased, in both groups, after amiloride administration and after Na+ removal. After an acid-loading maneuver, pHi recovery was significantly higher (P < 0.03) in activa

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13

Galvis Rojas, Giovanni, Magnus Husberg, and Lars-Ake Levin. "Cost-effectiveness analysis of population-based screening for 6-gene panel testing for hereditary breast and ovarian cancer." Journal of Clinical Oncology 43, no. 16_suppl (2025): 10541. https://doi.org/10.1200/jco.2025.43.16_suppl.10541.

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10541 Background: Genetic testing for hereditary breast and ovarian cancer (HBOC) has relied on clinical and family history criteria. This approach, has been shown to overlook a significant number of mutation carriers who could benefit from preventative measures. Increasing evidence supports genetic testing in an unselected population, which facilitates the identification of more carriers and allows for the implementation of risk reduction strategies. The aim of this study is to evaluate the cost-effectiveness of utilising an expanded gene-panel in an unselected female population. Methods: A M

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14

Iwasaki, Atsushi, Takayuki Saitoh, Chiaki Ushie, et al. "Polymorphisms of IL-10, IL-17A, IL-17F and IL-18 Affect the Clinical Features of Multiple Myeloma in Japanese Patients." Blood 120, no. 21 (2012): 4972. http://dx.doi.org/10.1182/blood.v120.21.4972.4972.

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Abstract Abstract 4972 Background: The growth of plasma cells in multiple myeloma (MM) is dependent on a complex interplay among various cytokines, adhesion molecules and other factors in the tumor microenvironment. Several cytokines, including Interleukin (IL)-6, IL-10 and IL-17 have been shown to promote myeloma cell growth in vitro. Furthermore, several investigators have shown the increase in levels of serum IL-6, IL-10, IL-17, and IL-18 in MM patients compared with healthy donors. Although many studies have shown that the dysregulation of these cytokines can be associated with MM developm

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15

Marshall, Skye, Graeme G Rich, Felicity Cohen, Asha Soni, and Elizabeth Isenring. "Matched Endoscopic Sleeve Gastroplasty and Laparoscopic Sleeve Gastrectomy Cases: Formative Cohort Study." JMIR Formative Research 6, no. 11 (2022): e29713. http://dx.doi.org/10.2196/29713.

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Background Bariatric weight-loss surgery rates are increasing internationally. Endoscopic sleeve gastroplasty (ESG) is a novel, minimally invasive endoscopic procedure thought to mimic some of the effects of a more common surgery, laparoscopic sleeve gastrectomy (LSG). Patient factors affecting procedural choice are unexplored. Objective This formative study aimed to determine the preoperative and early postoperative characteristics of adults matched for age, sex, and BMI who chose ESG versus LSG. Methods This prospective cohort study recruited ESG and matched LSG adults in Australia. Preopera

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16

Boussaid, S., M. Ben Majdouba, S. Jriri, et al. "FRI0618-HPR EFFECTS OF MUSIC THERAPY ON PAIN, ANXIETY, AND VITAL SIGNS IN CHRONIC INFLAMMATORY RHEUMATIC DISEASES PATIENTS DURING BIOLOGICAL DRUGS INFUSION." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 914.2–914. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6027.

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Background:Music therapy is based on ancient cross-cultural beliefs that music can have a “healing” effect on mind and body. Research determined that listening to music can increase comfort and relaxation, relieve pain, lower distress, reduce anxiety, improve positive emotions and mood, and decrease psychological symptoms. Music therapy has been used greatly in various medical procedures to reduce associated anxiety and pain. Patients have a high level of anxiety when they are in the hospital, this is the case of patients with rheumatic diseases who consult regularly to have intravenous infusi

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17

Milhem, Mohammed M., Georgina V. Long, Christopher J. Hoimes, et al. "Phase 1b/2, open label, multicenter, study of the combination of SD-101 and pembrolizumab in patients with advanced melanoma who are naïve to anti-PD-1 therapy." Journal of Clinical Oncology 37, no. 15_suppl (2019): 9534. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.9534.

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9534 Background: SD-101 is a synthetic CpG TLR9 agonist. Pembrolizumab is a PD-1 inhibitor. SYNERGY-001/KEYNOTE-184 assesses the safety and preliminary efficacy of the combination of SD-101 and pembrolizumab in patients naïve to anti-PD-1/L1 therapy with unresectable stage IIIC-IV melanoma. Methods: SD-101 was evaluated as 2 mg/lesion injected into 1 to 4 lesions and 8 mg/lesion in 1 lesion as 4 weekly doses followed by 7 doses Q3W. Pembrolizumab was administered as 200 mg IV Q3W. CT scans were performed every 9 weeks. Responses were assessed per investigator using RECIST v1.1. Responses and p

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18

Egeland Christensen, I., I. Jyssum, A. T. Tveter, et al. "OP0176 THE PERSISTENCE OF ANTI-SPIKE ANTIBODIES FOLLOWING TWO SARS-CoV-2 VACCINES IN PATIENTS WITH IMMUNE-MEDIATED INFLAMMATORY DISEASES USING IMMUNOSUPPRESSIVE THERAPY, COMPARED TO HEALTHY CONTROLS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 116–17. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2054.

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BackgroundLimited data is available regarding long-term effectiveness of SARS-CoV-2 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy. Whether the persistence of vaccine-induced humoral immunity against SARS-CoV-2 differs between this patient population and the general public is currently unknown.ObjectivesTo compare the persistence of anti-Spike antibodies following two SARS-CoV-2 vaccine doses between IMID patients using immunosuppressive medication and healthy controls and identify predictors of antibody decline.MethodsWe included patients

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19

Klein Goldewijk, Kees, Arthur Beusen, Jonathan Doelman, and Elke Stehfest. "Anthropogenic land use estimates for the Holocene – HYDE 3.2." Earth System Science Data 9, no. 2 (2017): 927–53. http://dx.doi.org/10.5194/essd-9-927-2017.

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Abstract. This paper presents an update and extension of HYDE, the History Database of the Global Environment (HYDE version 3.2). HYDE is an internally consistent combination of historical population estimates and allocation algorithms with time-dependent weighting maps for land use. Categories include cropland, with new distinctions for irrigated and rain-fed crops (other than rice) and irrigated and rain-fed rice. Grazing lands are also provided, divided into more intensively used pasture and less intensively used rangeland, and further specified with respect to conversion of natural vegetat

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20

Angkustsiri, Kathleen, Tony J. Simon, and Paul D. Hastings. "2117." Journal of Clinical and Translational Science 1, S1 (2017): 69. http://dx.doi.org/10.1017/cts.2017.244.

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OBJECTIVES/SPECIFIC AIMS: Chromosome 22q11.2 deletion syndrome (22q) has a prevalence almost as common as Down syndrome. 22q is well known for medical complications, including congenital heart disease and immune dysfunction. However, children with 22q also have borderline cognitive abilities, are at high risk for ADHD and anxiety, and have poor independent living skills (adaptive function). Parenting is one modifiable factor that has been found in typically developing populations to promote independent functioning and protect against the development of anxiety disorders. This study investigate

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21

Fidesrinur, Nurfadilah, Zahrina Amelia, and Astri Lestari. "Using Smart Apron Learning Media in Teaching Early Literacy Skills." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 98–107. http://dx.doi.org/10.21009/jpud.171.07.

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Literacy is one area of academic skills that can help children learn to read more easily and can influence skills in other academic areas. This study aims to describe the use of smart aprons learning media in teaching early literacy skills in schools that already use it in the Greater Jakarta area. This qualitative descriptive research was carried out in August 2022 with 11 teachers as respondents. Collecting data using observation techniques, interviews, and documentation. The validity of the data is obtained through data triangulation. The results of the study show that the use of smart apro

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22

Kubica, Claudia, Sascha Ketelhut, and Claudio R. Nigg. "Effects of a training intervention tailored to the menstrual cycle on endurance performance, recovery and well-being in female recreational runners – A randomized-controlled pilot study." Current Issues in Sport Science (CISS) 8, no. 2 (2023): 026. http://dx.doi.org/10.36950/2023.2ciss026.

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Introduction Female endurance athletes, such as runners, show a high prevalence of menstrual cycle (MC) related symptoms and diseases (Dusek, 2001). Almost one in four runners and 65% of long-distance runners are suffering from secondary amenorrhea (Dusek, 2001) and consecutive symptoms, such as an increased risk of injury, reduced bone mass, and a higher risk for cardiovascular diseases (Ihalainen et al., 2021). Causes for MC-related symptoms or diseases are multifactorial but in sports, a relationship to the training load, recovery, and sufficient energy availability exists (Redman & Lou

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23

Cooley, Sarah, Michael R. Verneris, Julie Curtsinger, et al. "Recombinant Human IL-15 Promotes in Vivo Expansion of Adoptively Transferred NK Cells in a First-in-Human Phase I Dose Escalation Study in Patients with AML." Blood 120, no. 21 (2012): 894. http://dx.doi.org/10.1182/blood.v120.21.894.894.

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Abstract Abstract 894 Adoptive transfer of haploidentical NK cells can induce remissions in patients with refractory AML. However, many do not expand NK cells and fail to respond. While IL-2 can promote NK cell proliferation, it also promotes the expansion of regulatory T cells, which impede NK cell expansion. Because IL-15 has different effects on regulatory T cells than IL-2, we initiated a phase I dose escalation trial of recombinant human IL-15 to enhance adoptive transfer of NK cells. Patients with refractory AML receive a lymphodepleting preparative regimen of fludarabine 25 mg/m2 × 5 da

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24

Bertoli, Sarah, Suzanne Tavitian, Emilie Berard, et al. "More Than 10% of NPM1-Mutated AML Relapses Occur after 5 Years from Complete Remission." Blood 132, Supplement 1 (2018): 2802. http://dx.doi.org/10.1182/blood-2018-99-113109.

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Abstract The majority of relapses in acute myeloid leukemia (AML) patients occur in the first or second year following complete remission. In routine, AML patients are followed during five years because few relapses can occur after three or five years. These late or very late relapses remain poorly described, particularly at the molecular level, with only few consistent series in the literature. (Medeiros B et al., Leuk Lymphoma 2007; Verma D et al., Leuk Lymphoma 2010; Watts J et al., Leuk Res 2014). We retrospectively studied all AML relapses occurring after complete remission (CR) obtained

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25

Parker, Wendy T., Musei Ho, Rebecca M. Lawrence, et al. "Detection of Low Level Nilotinib or Dasatinib Resistant BCR-ABL Mutations by Mass Spectrometry In CML Patients Who Fail Imatinib Is Highly Predictive of Their Subsequent Clonal Expansion When Treated with the Drug for Which Their Mutation Confers Resistance." Blood 116, no. 21 (2010): 891. http://dx.doi.org/10.1182/blood.v116.21.891.891.

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Abstract Abstract 891 Imatinib (IM) resistance is commonly associated with the acquisition of BCR-ABL kinase domain (KD) mutations. Nilotinib (NIL) and dasatinib (DAS) are active against the majority of IM resistant mutations, however a small number confer clinical resistance to NIL (Y253H, E255K/V and F359V/C) or DAS (V299L, T315A and F317L/I), or both (T315I). These mutations are associated with low response rates and their detection after IM failure aids selection of the most appropriate therapy; however, mutations may be present below the detection limit of conventional direct sequencing (

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26

GADOMSKA, Anna, Justyna KUREK, Rafał GORZYŃSKI, et al. "Hypothyroidism in pregnancy - a review." Journal of Education, Health and Sport 36, no. 1 (2023): 82–94. https://doi.org/10.12775/JEHS.2023.36.01.009.

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<strong>GADOMSKA, Anna, KUREK, Justyna, GORZYŃSKI, Rafał, GARSTKA, Michał, DOMINIK, Hanna, CZUDY, Zuzanna, PAWĘSKA, Wojciech, MOLCZYK-SIEŃCZAK, Justyna, RADWAŃSKI, Jan and POLATOWSKA, Marika. Hypothyroidism in pregnancy - a review</strong><strong>. </strong><strong>Journal of Education, Health and Sport. 2023;</strong><strong>36</strong><strong>(1):</strong><strong>82-94.</strong><strong> eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.12775/JEHS.2023.3</strong><strong>6</strong><strong>.01.0</strong><strong>09</strong> <strong>https://apcz.umk.pl/JEHS/article/view/44</strong><

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27

Gerotziafas, Grigorios T., Flora Zagouri, Despina Fotiou, et al. "Newly Diagnosed Multiple Myeloma Is Associated with Enhanced TF Pathway Activation, Thrombin Generation and Increased Concentration of Procoagulant Microparticles." Blood 126, no. 23 (2015): 1074. http://dx.doi.org/10.1182/blood.v126.23.1074.1074.

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Abstract Background: Multiple myeloma (MM) and plasma cell dyscrasias (PCD) are associated with increased risk of venous thromboembolism (VTE) which is further enhanced by treatments with immunomodulatory agents, melphalan or steroids. The optimization of VTE prevention in patients with MM is an unmet need. According to Virchow's triad, blood hypercoagulabilty is one of the three conditions required for thrombosis. Elaboration of a risk assessment model, which includes biomarkers of hypercoagulability, could lead to better identification of MM patients eligible for pharmacological thromboproph

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28

Kennah, Michael, Nastaran Noroozi, Esther Masih-Khan, et al. "Patient, Disease and Treatment Characteristics of Long-Term Survivors of Multiple Myeloma." Blood 124, no. 21 (2014): 2019. http://dx.doi.org/10.1182/blood.v124.21.2019.2019.

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Abstract Introduction With routine use of autologous stem cell transplantation (ASCT) and novel agents, survival of patients with multiple myeloma (MM) has improved in recent years. Yet, MM remains incurable and long-term survivors (LTS) of ≥10 years from diagnosis remain uncommon. This study aims to identify patient, disease and treatment characteristics of MM LTS, with particular interest in the effect of novel therapies. Methods A retrospective analysis was conducted of MM patients diagnosed between 1998 and 2002 and treated at Princess Margaret Cancer Centre, a tertiary care institution. L

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KUREK, Justyna, Anna GADOMSKA, Rafał GORZYŃSKI, et al. "Blue light emitted from digital devices - impact on our sleep." Journal of Education, Health and Sport 40, no. 1 (2023): 68–82. https://doi.org/10.12775/JEHS.2023.40.01.007.

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<strong>KUREK, Justyna, GADOMSKA, Anna, GORZYŃSKI, Rafał, MOLCZYK-SIEŃCZAK, Justyna, GARSTKA, Michał, DOMINIK, Hanna, CZUDY, Zuzanna, PAWĘSKA, Wojciech, RADWAŃSKI, Jan & POLATOWSKA, Marika. Blue light emitted from digital devices - impact on our sleep. </strong><strong>Journal of Education, Health and Sport. 2023;</strong><strong>40</strong><strong>(1):</strong><strong>68-82.</strong><strong> eISSN 2391-8306. DOI</strong> <strong>http://dx.doi.org/10.12775/JEHS.2023.40.01.00</strong><strong>7</strong> <strong>https://apcz.umk.pl/JEHS/article/view/440</strong><strong>2</strong><st

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Catapano, Joshua S., Stefan W. Koester, Kavelin Rumalla, et al. "A Review of Preoperative Embolization Effectiveness in Patients With Arteriovenous Malformations." Neurosurgery, July 31, 2023. http://dx.doi.org/10.1227/neu.0000000000002629.

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BACKGROUND AND OBJECTIVES: Preoperative embolization of arteriovenous malformations (AVMs) remains controversial. This study sought to analyze the cost-effectiveness of preoperative embolization of AVMs. METHODS: Patients who underwent AVM resection at a single institute (January 1, 2015—December 31, 2020) were analyzed. Patients with preoperative embolization (embolization cohort) were compared with those without preoperative embolization (nonembolization cohort). Cost-effectiveness score (CE) was the primary outcome of interest and was determined by dividing the total 1-year cost by effectiv

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Carnero Montoro, L., M. Ruiz Ortiz, S. Rodriguez Diego, et al. "P937 Left atrial longitudinal strain as a marker of acute cellular rejection in heart transplant recipients: impact of intervendor variability." European Heart Journal - Cardiovascular Imaging 21, Supplement_1 (2020). http://dx.doi.org/10.1093/ehjci/jez319.570.

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Abstract Introduction and purpose Preliminary reports suggests that left atrial longitudinal strain (LALS) variables are a sensitive marker of acute cellular rejection (ACR) in heart transplant recipients (HTxR), discriminating between those studies without rejection and those with any grade of rejection. Intervendor variability is a concern in the widespread use of this technique. Our objective was to compare the LALS evaluated by two different softwares. Methods From September 2014 to October 2016 we performed, in 18 consecutive adult HTxR in their first year posttransplantation, serial echo

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Cosmi, D., B. Mariottoni, and F. Cosmi. "P2554Bleedings during antithrombotic therapy: a blessing in disguise." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz748.0882.

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Abstract Background and purpose Antithrombotic therapy in patients with heart diseases is associated with minor and major, sometimes fatal bleedings. On the other hand, bleeding can favor the diagnosis of diseases that have a significant impact on patient's prognosis. In our research, we evaluated the incidence of occult malignancies associated with bleeding during antithrombotic therapy. Methods In the last 5 years, we evaluated 20,154 outpatients. We found that antithrombotic therapy was performed in 9.356 (46%) of subjects. Of these, 6,560 took an antiplatelet monotherapy. 658 were on dual

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Babl, Franz E., David Herd, Meredith Borland, et al. "Efficacy of Prednisolone for Bell Palsy in Children: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial." Neurology, August 25, 2022, 10.1212/WNL.0000000000201164. http://dx.doi.org/10.1212/wnl.0000000000201164.

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Background and Objective:Corticosteroids are used to treat the early stages of idiopathic facial paralysis (Bell’s palsy) in children, but their effectiveness is uncertain. We set out to determine if prednisolone improves the proportion of children with Bell’s palsy with complete recovery at one month.Methods:We conducted a double-blind, placebo-controlled, randomised trial of prednisolone in children presenting to emergency departments with Bell’s palsy. Patients aged 6 months to less than 18 years, recruited within 72 hours after symptom onset, were randomly assigned to receive 10 days of tr

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Metwally, Ammal M., Abdelrahman Hassanein, Safaa I. Abd El Hady, et al. "Exploring the role of posthumous organ donation attitudes: A comparative study of Egyptian cancer patients and healthy individuals." Journal of Clinical Oncology 43, no. 16_suppl (2025). https://doi.org/10.1200/jco.2025.43.16_suppl.e22605.

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e22605 Background: Organ transplantation is a critical intervention for patients with end-stage organ failure, including those suffering from cancer-related organ damage. This study examines how chronic illness, specifically cancer, affects these attitudes by comparing cancer patients to healthy individuals and explores their awareness of relevant Egyptian laws. Methods: A cross-sectional study was conducted in two Egyptian governorates, involving 6,000 participants equally divided between cancer patients and healthy individuals. Data were collected through structured interviews and self-admin

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Sorour, Ahmed A., Betemariam Sharew, Casey Kuka, et al. "No difference in midterm outcomes and complication rate between retroperitoneal and transperitoneal open aortic aneurysm repair in females." Vascular, June 11, 2024. http://dx.doi.org/10.1177/17085381241257742.

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Objectives Abdominal Aortic Aneurysms (AAA) in females are less prevalent, have higher expansion rates and experience rupture at smaller diameters than in males. Studies have compared outcomes of the retroperitoneal (RP) and transperitoneal (TP) approach in open aortic aneurysm repair (OAR) with conflicting results. No study to date has compared the two approaches solely in females. In this study we compare midterm outcomes of the RP and TP approach in females undergoing OAR. Methods Single-center, retrospective review of all females undergoing OAR from 2010 to 2021. Patients undergoing electi

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Montanari, Alberto, Almerina Biggi, Nicoletta Carra, et al. "Endothelin-A Receptors Mediate Renal Hemodynamic Effects of Exogenous Angiotensin II in Humans." August 19, 2003. https://doi.org/10.1161/01.hyp.0000088361.26773.08.

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To investigate whether endothelin-A receptors mediate hemodynamic changes caused by exogenous Angiotensin II in humans, 7 healthy volunteers on a 250-mmol sodium diet underwent 3 separate p -aminohippurate and inulin-based renal hemodynamic studies. In 2 studies, Angiotensin II (increasing rates of 0.625, 1.25, and 2.5 ng/kg per minute, each for 30 minutes) was infused either alone or combined with endothelin-A blocker, BQ123, 0.4 nmol/kg per minute. A third infusion of BQ123 alone was not followed by any change. Angiotensin II infusion alone produced a progressive decrease in renal blood flow

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Stefan, Gabriel, Cinca Simona-Mihaela, Adrian Dorin Zugravu, Nicoleta Petre, and Simona Stancu. "#1644 Prognostic significance of hematuria on kidney survival in podocytopathies." Nephrology Dialysis Transplantation 39, Supplement_1 (2024). http://dx.doi.org/10.1093/ndt/gfae069.407.

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Abstract Background and Aims Hematuria is common in podocytopathies, but its prognostic impact on kidney survival in these proteinuric diseases is not well-established. Our study examines the prevalence of hematuria at podocytopathy diagnosis and its association with renal survival. Method In our retrospective study, we analyzed 236 patients (median age 50 years, 60% male, median eGFR 65.5 mL/min/1.73 m2, median proteinuria 3.9g/g) with biopsy proven podocytopathies—48% membranous nephropathy (MN), 32% minimal change disease (MCD), 20% focal and segmental glomerulosclerosis (FSGS)—diagnosed at

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Tracy, Phillip, Joel Hill, Jai Liester, Kevin Sullivan, and James Pearson. "Influence of progressive skin heating upon arterial blood pressure and tolerance to a simulated hemorrhage challenge following exercise in a cold environment." Physiology 39, S1 (2024). http://dx.doi.org/10.1152/physiol.2024.39.s1.1637.

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Purpose: Our aim was to examine the role of graded skin heating on blood pressure and tolerance to a simulated hemorrhage (lower body negative pressure, LBNP) in individuals who have exercised in a cold environment. We hypothesized that arterial blood pressure and tolerance would be lower during LBNP at higher skin temperatures. Methods: Following completion of a maximal exercise test, 7 participants (181±7 cm, 88.7±14 kg and 25±6 yrs) four exercise cold stress trials, comprising high intensity interval exercise on a cycle ergometer: 5 min at 60% VO2 max (1.9±0.4 L.O2.min) followed by 15 inter

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Hwang, M., R. Shamburek, M. Lightbourne, et al. "5123 Remission of Antibodies Blocking the Insulin Receptor Reduces Atherogenicity of LDL Particles but Increases HDL Particle Atherogenicity." Journal of the Endocrine Society 8, Supplement_1 (2024). http://dx.doi.org/10.1210/jendso/bvae163.605.

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Abstract Disclosure: M. Hwang: None. R. Shamburek: None. M. Lightbourne: None. M. Sampson: None. A. Remaley: None. B. Abel: None. R.J. Brown: None. Background: Type B insulin resistance syndrome (TBIR) is a rare autoimmune disorder defined by the presence of autoantibodies against the insulin receptor, usually in the context of systemic autoimmune diseases such as lupus. In TBIR, insulin signaling is disrupted at the receptor-level, resulting in failure of insulin to both suppress hepatic glucose production and to stimulate de novo lipogenesis. This leads to a phenotype of extreme insulin resi

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Bac, Bui Van. "Effects of Land use Change on Coprini dung Beetles in Tropical Karst Ecosystems of Puluong Nature Reserve." VNU Journal of Science: Natural Sciences and Technology 35, no. 4 (2019). http://dx.doi.org/10.25073/2588-1140/vnunst.4930.

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I examined variation in community structure, species richness, biomass and abundance of Coprini dung beetles from 45 trapping sites in meadows, 35-year-old secondary forests and primary forests in tropical, high-elevation karst ecosystems of Puluong Nature Reserve, Thanh Hoa Province. My main aim was to explore community response to the influence of land use change. By comparing the structure and community attributes of the beetles between 35-year-old secondary forests and primary forests, I expected to give indications on the conservation value of the old secondary forests for beetle conserva

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Ostrea, Jr., Enrique M. "Prevention of Fetal Neural Tube Defect with Folic Acid Supplementation." Acta Medica Philippina 56, no. 5 (2022). http://dx.doi.org/10.47895/amp.v56i5.5539.

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Neural tube defects (NTDs), such as spinal cord and brain defects, are due to abnormal embryonic development of the neural tube and associated with increased fetal and infant mortality, morbidity, lifelong disability, and high economic costs. Globally, more than 260,000 pregnancies are estimated to be affected by NTDs, and 75% of the NTD live births result in under-5 deaths.1 Majority of NTDs are folic acid-sensitive; with much of the NTD burden preventable through consumption of folic acid before and during early pregnancy (periconception). An association between low folate status of women of

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Gazi, Md. Shakhawat Hossain, Shahinur Rahman Md., and Das amir. "A Structural Equation Modeling (SEM) Approach to Explore the Association between Corporate Social Responsibility and Financial Performance: A Single Mediating Mechanism." August 27, 2019. https://doi.org/10.5281/zenodo.3378207.

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<strong><em>Abstrac</em></strong><em>t</em>: <em>The past couple of decades have seen a growing interest in Corporate Social Responsibility (CSR) research in both business and academia. It has been observed that a substantial number of studies on CSR and Financial Performance (FINP) have focused almost entirely on large firms. As pointed out earlier, the bulk number of studies on the link between CSR-firm performances is from developed countries. Thus, a limited number of studies have been conducted in developing countries and more especially in Bangladesh. We cannot generalize the findings fr

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sprotocols. "A simple improvement of the conventional cryopreservation for human ES and iPS cells." December 31, 2014. https://doi.org/10.5281/zenodo.13659.

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Authors: Midori Ozawa, Yutaka Ozawa, Masashi Iemura, Arihiro Kohara, Kana Yanagihara & Miho K Furue ### Abstract In this study, a simple method for the cryopreservation of human embryonic stem (ES) and induced pluripotent stem (iPS) cells is proposed. It is based on the conventional slow-freezing method with 10% DMSO and modified mainly in a thawing protocol without specific equipment or reagents. Recovery rate of the cells cryopreserved by this method was equally high, which is comparable to that of the cells frozen by the vitrification method. In the case of vitrification method, it requ

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Thanh Binh, Nguyen Thi, Nguyen Thi Hai Yen, Dang Kim Thu, Nguyen Thanh Hai, and Bui Thanh Tung. "The Potential of Medicinal Plants and Bioactive Compounds in the Fight Against COVID-19." VNU Journal of Science: Medical and Pharmaceutical Sciences 37, no. 3 (2021). http://dx.doi.org/10.25073/2588-1132/vnumps.4372.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus , is causing a serious worldwide COVID-19 pandemic. The emergence of strains with rapid spread and unpredictable changes is the cause of the increase in morbidity and mortality rates. A number of drugs as well as vaccines are currently being used to relieve symptoms, prevent and treat the disease caused by this virus. However, the number of approved drugs is still very limited due to their effectiveness and side effects. In such a situation, medicinal plants and bioactive compounds are considered a highly valuabl

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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