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Статті в журналах з теми "005. 32: 316. 46 (043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Karkash, Ahmad, Weston He, Paresh Kumar, Mya Tran, Julian A. Marin-Acevedo, and Misty Dawn Shields. "Comparison of outcomes for patients diagnosed with small cell lung cancer between a university and safety net hospital." Journal of Clinical Oncology 43, no. 16_suppl (2025): 12077. https://doi.org/10.1200/jco.2025.43.16_suppl.12077.

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12077 Background: With immunotherapy, the five year overall survival (OS) for small cell lung cancer (SCLC) is 12%. However, real world factors such as social determinants of health (SDH) and enrollment to clinical trials may vary. Here, we compare treatment patterns and outcomes for SCLC between two affiliated hospital settings. Methods: A retrospective analysis was conducted on patients with SCLC seen at university hospital (UH, Indiana University Melvin and Bren Simon Comprehensive Cancer Center) or its affiliate safety net hospital (SNH, Sidney and Lois Eskenazi Hospital) from 1/1/2018 to

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2

Yoh, Kyung Ah, Ho Sup Lee, Lee Chun Park, Eun Mi Lee, Dae Jin Park, and Yang Soo Kim. "Prognostic Significance of Elevated Serum Ferritin Before Chemotherapy in Patients with Non-Hodgkin's Lymphoma." Blood 120, no. 21 (2012): 5099. http://dx.doi.org/10.1182/blood.v120.21.5099.5099.

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Abstract Abstract 5099 Background: Elevated ferritin level before stem cell transplantation was documented an adverse prognostic factor for patients undergoing hematopoietic stem cell transplantation for hematologic malignancies. Until now, there have been reported few studies which suggested high serum ferritin level were associated with worse outcomes for lymphoma. The purpose of this study was to find the significance of high levels of serum ferritin for predicting survival outcome in patients with non-Hodgkin's lymphoma (NHL). Methods: A total of 267 patients who newly diagnosed and receiv

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3

Gerasimova, E., T. Popkova, A. Aleksankin, and D. Tabakov. "POS0622 THE BLOOD T-CELL SUBSETS IN RHEUMATOID ARTHRITIS PATIENTS ON LONG-TERM IL-6 RECEPTOR BLOCKER THERAPY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 549.1–549. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2310.

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Background:Pleiotropic effects of IL-6 receptor antagonist tocilizumab (TCZ) in rheumatoid arthritis (RA) involve circulating T-cells. Preliminary reports have suggested that TCZ therapy can modulate T cell function and humoral immune responses in RA [1,2]. According to other studies, TCZ had no influence on T-lymphocyte subdifferentiation [3].Objectives:To assess the effect of 12 months (m) TCZ therapy on T-cell phenotype, and to analyze the association between T-cell subsets and RA activity.Methods:36 active RA pts (29F/7M); median age 55[46; 64] years; disease duration 120[72; 1928]m; DAS28

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4

Zhu, Katie Y., Kevin W. Song, Joseph M. Connors, et al. "Population-Based Survival Outcomes in Adult Patients with Burkitt Lymphoma (BL) Treated with Cyclophosphamide, Vincristine, Doxorubicin, High-Dose Methotrexate (CODOX-M)/Ifosfamide, Etoposide and High-Dose Cytarabine (IVAC) Plus or Minus Rituximab (R) in British Columbia (BC), Canada." Blood 128, no. 22 (2016): 1113. http://dx.doi.org/10.1182/blood.v128.22.1113.1113.

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Abstract Background: Burkitt lymphoma (BL) is a highly aggressive non-Hodgkin lymphoma associated with translocations involving the c-MYC oncogene on chromosome 8. The 1996 Magrath regimen, CODOX-M/IVAC, showed a promising 2-year (y) event free survival (EFS) of 92% in 41 BL patients (pts), with additional trials of a dose-modified regimen demonstrating 2y overall survival (OS) 70-82% and 2y progression-free survival (PFS) 64% (Mead et al). A recent trial demonstrated that with addition of R, 3y OS and EFS were 83% and 75% (Ribrag et al). We sought to determine survival outcomes of adult BL pt

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5

Bowmaker, Graham A., Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. I Large-Cation (2,2′-Bipyridinium and 1,10-Phenan- throlinium) Salts of Polyhalobismuthate(III) Ions." Australian Journal of Chemistry 51, no. 4 (1998): 293. http://dx.doi.org/10.1071/c97036.

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Syntheses and room-temperature single-crystal X-ray studies are recorded for a variety of salts of cations derived from protonated 2,2′-bipyridine and 1,10-phenanthroline (bpyH+ and phenH+) with polyhalobismuthate(III) anions. ‘[(phenH)(phenH2)(H2O)2] [BiCl6]’ is triclinic, P-1, a 9·791(1), b 9·338(3), c 8·311(3) Å, α 73·46(3), β 69·71(2), γ 86·36(2)°, Z = 1; conventional R on |F| was 0·027 for No 4852 independent ‘observed’ (I > 3σ(I)) reflections. [BiCl6]3- is closely octahedral, accompanied by an interesting protonation/hydrogen-bonding array among the other moieties. The latter comment

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6

Flouri, I., A. Repa, N. Avgustidis, et al. "AB0375 IN PATIENTS STARTING ETANERCEPT, MALE SEX, ABSENCE OF COMORBIDITIES AND NO csDMARDs CO-ADMINISTRATION ARE INDEPENDENT PREDICTORS OF LONG-TERM (MORE THAN 3 YEARS) PERSISTENCE TO THERAPY, IRRESPECTIVELY OF THE CLINICAL DIAGNOSIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1314.2–1315. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4826.

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BackgroundComparative data among rheumatoid arthritis (RA), spondylarthritis (SpA) and psoriatic arthritis (PsA) patients regarding long-term survival of etanercept (ETN) in clinical practice are limited.ObjectivesThe first aim of this study was to analyze the long-term (>3 years) ETN survival comparatively between its three main indications. We also aimed to analyze for predictors of long term ETN survival.MethodsWe analyzed data from the University of Crete Rheumatology Clinic Registry (UCRCR), a single center prospective cohort study. All patients with a diagnosis of RA, SpA or PsA start

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7

Wenzel, Mike, Florestan Koll, Benedikt Hoeh, et al. "Cancer-control outcomes of metastatic castration resistant prostate cancer patients with BRCA -gene or tumor suppressor mutations undergoing 177-lutetium PSMA radioligand therapy." Journal of Clinical Oncology 43, no. 5_suppl (2025): 71. https://doi.org/10.1200/jco.2025.43.5_suppl.71.

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71 Background: Several tumor gene mutations are known for metastatic castration-resistant prostate cancer (mCRPC) are known. The individual response to 177-Lutetium Prostate-specific membrane antigen (Lu-PSMA) therapy is under current investigation regarding the genomic profile of mCRPC patients. Methods: We relied on the FRAMCAP database and compared progression-free (PFS) and overall survival (OS) rates of mCRPC patients with Breast Cancer related antigen ( BRCA ) or tumor suppressor gene mutations ( TP53, PTEN, RB1 [TSG]). Especially, subgroup analyses were performed for Lu-PSMA-treated mCR

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8

Suzuki, Gen, Brian R. Weil, Rebeccah F. Young, James A. Fallavollita, and John M. Canty. "Nonocclusive multivessel intracoronary infusion of allogeneic cardiosphere-derived cells early after reperfusion prevents remote zone myocyte loss and improves global left ventricular function in swine with myocardial infarction." American Journal of Physiology-Heart and Circulatory Physiology 317, no. 2 (2019): H345—H356. http://dx.doi.org/10.1152/ajpheart.00124.2019.

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Intracoronary cardiosphere-derived cells (icCDCs) infused into the infarct-related artery reduce scar volume but do not improve left ventricular (LV) ejection fraction (LVEF). We tested the hypothesis that this reflects the inability of regional delivery to prevent myocyte death or promote myocyte proliferation in viable myocardium remote from the infarct. Swine ( n = 23) pretreated with oral cyclosporine (200 mg/day) underwent a 1-h left anterior descending coronary artery (LAD) occlusion, which reduced LVEF from 61.6 ± 1.0 to 45.3 ± 1.5% 30 min after reperfusion. At that time, animals receiv

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9

Gamboa-Alonso, C. M., M. J. Garza Martínez, B. R. Vázquez Fuentes, et al. "SAT0206 MINOR SALIVARY GLAND BIOPSY AND SEROLOGICAL PROFILE IN PRIMARY SJÖGREN’S SYNDROME: A SINGLE TERTIARY REFERRAL CENTER EXPERIENCE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1046.2–1046. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6278.

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Background:Minor salivary gland biopsy (MSGB) portrays an important role as part of the diagnostic criteria of primary Sjögren’s syndrome (pSS) in the ACR/EULAR 2016 classification. Autoantibodies anti-Ro/SSA and anti-La/SSB embody part of these criteria. Patients with negative serology have been classified as pSS using MSGB outcomes in up to 40% of cases.Objectives:Compare MSGB and serological characteristics between pSS positive biopsy versus pSS negative biopsy and sicca groups.Methods:174 subjects with sicca symptoms and MSGB biopsy were studied. Patients who fulfilled the ACR/EULAR 2016 c

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10

Deodhar, A., S. Kafka, E. C. Hsia, et al. "POS0902 EFFICACY AND SAFETY OF INTRAVENOUS GOLIMUMAB IN ANKYLOSING SPONDYLITIS PATIENTS WITH EARLY VS LATE DISEASE THROUGH WEEK 52 OF GO-ALIVE STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 708–9. http://dx.doi.org/10.1136/annrheumdis-2021-eular.220.

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Background:The GO-ALIVE study assessed efficacy and safety of intravenous golimumab (IV GLM) in patients (pts) with ankylosing spondylitis (AS).1,2Objectives:In this post hoc analysis, we assessed IV GLM efficacy and safety in AS pts with early disease (ED) vs late disease (LD) based on pt-reported duration of inflammatory back pain (IBP).Methods:In this Phase 3, double-blind, placebo (PBO)-controlled trial, pts with active AS were randomized (1:1) to receive IV GLM 2 mg/kg at Week (W) 0, W4, then Q8W or PBO at W0, W4, and W12 with crossover to IV GLM at W16, W20, then Q8W through 52. The prim

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11

Pinto, B., S. Cs, D. Susanne, et al. "SAT0227 CLINICAL AND IMMUNOLOGICAL PROFILE OF NEUROPSYCHIATRIC LUPUS IN SOUTH INDIA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1056.2–1056. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4010.

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Background:Neuropsychiatric manifestations are one of the least understood aspects of SLE.Objectives:To study the prevalence of NPSLE manifestations in our cohort and compare clinical and immunological features of patients with controls.Methods:This was a retrospective study in a tertiary care centre. Classification of SLE was as per SLICC criteria. All patients of SLE diagnosed in the last 5 years with NP manifestations as per the ACR definitions were included. Consecutive patients of SLE over last 2 years without NP manifestations were taken as controls.Results:Six hundred and thirty one pat

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12

Brunstein, Claudio G., Juliet N. Barker, Todd E. DeFor, Kathy French, Daniel J. Weisdorf, and John E. Wagner. "Non-Myeloablative (NMA) Umbilical Cord Blood Transplantation (UCBT): Promising Disease-Free Survival in 95 Consecutive Patients." Blood 106, no. 11 (2005): 559. http://dx.doi.org/10.1182/blood.v106.11.559.559.

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Abstract Conventional allogeneic hematopoietic stem cell transplantation (HSCT) is limited by lack of rapidly available HLA-matched donors and excess transplant-related mortality (TRM). Therefore, we investigated the use of unrelated UCBT after NMA conditioning in patients (pts) with high-risk hematologic malignancy. From 10/01 to 06/05, 95 consecutive adults [median age 50 yrs (range 18-69), median weight 78 kg (range 50-134)] received a NMA prior to UCBT. Pts were eligible if aged &gt;45 yrs (n=70; 74%), or had extensive prior therapy (n=25; 26% with 17 having had a prior autologous HSCT

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13

Molina Collada, J., F. Sánchez-Alonso, C. Bohórquez, et al. "OP0138 RISK OF CANCER AFTER BIOLOGIC AND TARGETED SYNTHETIC DMARDS INITIATION IN PATIENTS WITH RHEUMATIC DISEASES AND A HISTORY OF PRIOR MALIGNANCY: DATA FROM THE BIOBADASER REGISTRY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 88.2–89. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5030.

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BackgroundPatients with a history of cancer are routinely excluded from randomized controlled trials. As consequence, data on the safety of biologic disease modifying antirheumatic drugs (bDMARDS) and targeted synthetic (ts) DMARDs are limited. Although real world data from various national registries have not provided evidence of increased cancer recurrence, additional data from real-world registries may help to confirm safety of non-TNFi bDMARDs and tsDMARDs regarding cancer recurrence to guide treatment decisions.ObjectivesTo compare the risk of incident malignancy with exposure to differen

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14

Marshall, Skye, Graeme G Rich, Felicity Cohen, Asha Soni, and Elizabeth Isenring. "Matched Endoscopic Sleeve Gastroplasty and Laparoscopic Sleeve Gastrectomy Cases: Formative Cohort Study." JMIR Formative Research 6, no. 11 (2022): e29713. http://dx.doi.org/10.2196/29713.

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Background Bariatric weight-loss surgery rates are increasing internationally. Endoscopic sleeve gastroplasty (ESG) is a novel, minimally invasive endoscopic procedure thought to mimic some of the effects of a more common surgery, laparoscopic sleeve gastrectomy (LSG). Patient factors affecting procedural choice are unexplored. Objective This formative study aimed to determine the preoperative and early postoperative characteristics of adults matched for age, sex, and BMI who chose ESG versus LSG. Methods This prospective cohort study recruited ESG and matched LSG adults in Australia. Preopera

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15

De Montalembert, Mariane, Frédéric Galacteros, Jean Antoine Ribeil, et al. "Implementation of a European Cohort to Follow Sickle Cell Children and Adults Treated with Hydroxycarbamide." Blood 124, no. 21 (2014): 564. http://dx.doi.org/10.1182/blood.v124.21.564.564.

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Abstract Hydroxycarbamide (HU) is a myelosuppressive drug marketed since 1968 for the treatment of hematological cancer, and authorized since 2007 in Europe as orphan medicinal product for the prevention of recurrent vaso-occlusive crises including acute chest syndrome in adults and children older than 2 years with sickle cell disease (SCD). ESCORT-HU (European Sickle Cell Disease Cohort – Hydroxyurea) is a multicenter prospective non interventional study implemented in Europe to collect more information about the safety profile of HU and morbi-mortality in SCD patients treated with HU. The st

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16

Li, Bing, Jinqin Liu, Shiqiang Qu, et al. "Colony-Forming Unit Cell (CFU-C) Assays in Myelodysplastic Syndrome." Blood 126, no. 23 (2015): 2874. http://dx.doi.org/10.1182/blood.v126.23.2874.2874.

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Abstract Introduction: The myelodysplastic syndromes (MDS) are a group of clonal diseases derived from hematopoietic stem cells (HSC). Colony-forming unit cell (CFU-C) assay is an effective method to study the number and the function of HSC in vitro. In this study, we focus on the characteristics and the prognostic value of CFU-C in patients with MDS. Patients and Method: CFU-C assays were performed according to the protocol of MethoCultTM H4435 Enriched (STEMCELL Technologies). A colony was defined as an aggregate of >40 cells. Clusters consisted of 4 to 40 cells. 560 consecutive newly-dia

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17

Ayan, G., A. Sadic, L. Kiliç, and U. Kalyoncu. "AB0946 Pelvis radiography findings and progression rates in patients with Psoriatic Arthritis under biologic treatment." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1601.2–1602. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3471.

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BackgroundPsoriatic arthritis (PsA) is a heterogenous disease that can present with various musculokeletal manifestations. Several studies have assessed the rate of sacroileitis in PsA population, however data on the involvement of other pelvic structures that may cause symptoms, such as major entheseal or hip involvevement, and progression rates during follow-up is scarce.ObjectivesThis study aimed to understand overall pelvis radiography findings and progression rates during follow-up in a cohort of patients with PsA under biologic treatment.MethodsPsA patients from the Hacettepe University

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18

Oran, Betul, Richard E. Champlin, Jorge E. Cortes, et al. "Allogeneic Hematopoietic Stem Cell Transplantation (HCT) in First Remission Improves Outcome Irrespective of FLT3-ITD Allelic Burden Among Patients with Acute Myeloid Leukemia and FLT3-ITD Mutation." Blood 124, no. 21 (2014): 2531. http://dx.doi.org/10.1182/blood.v124.21.2531.2531.

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Abstract Presence of internal tandem duplication in the FMS-like tyrosine kinase 3 gene(s) (FLT3-ITD) is associated with poor outcome among patients with cytogenetically normal acute myelogenous leukemia (CN-AML). Patients carrying a higher FLT3-ITD allelic burden have worse outcome. Allogeneic stem cell transplantation (SCT) in first remission (CR1) is reported to improve survival in this poor risk patients. We investigated the impact of FLT3-ITD allelic burden, number of FLT3-ITD mutations and SCT with a matched related or unrelated donor in CR1 in newly diagnosed FLT3-ITD mutated intermedia

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19

Wesseling, Jelle. "Abstract F1-2: Clonal evolution of DCIS to invasion." Cancer Research 83, no. 5_Supplement (2023): F1–2—F1–2. http://dx.doi.org/10.1158/1538-7445.sabcs22-f1-2.

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Abstract Clonal evolution of DCIS to invasion Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive breast cancer (IBC). If not treated, at least 3 out of 4 women with DCIS will not develop IBC1-3. This implies many women with non-progressive, low-risk DCIS are likely to carry the burden of overtreatment. To solve this DCIS dilemma, two fundamental questions need to be answered. The first question is, how the subsequent IBC is related to the initial DCIS lesion. The seco

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20

Fauziana, Hasna, and Ririn Tri Ratnasari. "The Effect of Health, Education, and Labor Force with Urban Population as Moderating Variables on Human Development Index in Oic Member Countries." Jurnal Ekonomi Syariah Teori dan Terapan 10, no. 1 (2023): 82–95. http://dx.doi.org/10.20473/vol10iss20231pp82-95.

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ABSTRACT: This study aims to examine the effect of health, education, and labor force moderated by urban population on the Human Development Index. This study uses a quantitative approach and a Moderated Regression Analysis technique with a sample of 25 OIC countries from 2010-2019 taken by purposive sampling method. The results showed that health, education, and the labor force affected the Human Development Index. While the urban population moderates the effect of health and the workforce on the Human Development Index, the urban population does not moderate the effect of education on the Hu

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21

Syifa Nurmilla Fathiyyah and Muhammad Muflih. "Determinants of Islamic Banking Profitability: A Comparative Analysis of Indonesia and Malaysia." Jurnal Ekonomi Syariah Teori dan Terapan 10, no. 4 (2023): 391–402. http://dx.doi.org/10.20473/vol10iss20234pp391-402.

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ABSTRACT Islamic banking in Indonesia and Malaysia experienced differences in asset growth and market share, potentially causing dissimilarity in profitability performance. This study aims to evaluate the factors that influence the increase in profitability of Islamic banking in Indonesia and Malaysia using signaling theory including market concentration (HHI), company size and financing risk (NPF), and national income (GDP) as control variables. It analyzed the Indonesian and Malaysian Islamic banks during the period 2017-2021. The method used in this study is comparative descriptive with pan

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22

Magnus, Dan, Santosh Bhatta, and Julie Mytton. "432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries." Emergency Medicine Journal 37, no. 12 (2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.

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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the fir

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23

Warmansyah, Jhoni, Afriyane Ismandela, Dinda Fatma Nabila, et al. "Smartphone Addiction, Executive Function, and Mother-Child Relationships in Early Childhood Emotion Dysregulation." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 241–66. http://dx.doi.org/10.21009/jpud.172.05.

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Early childhood emotional dysregulation is critical in recognizing and preventing psychological well-being disorders, laying the groundwork for developing healthy emotional behaviors early on. This study aims to determine the direct influence of smartphone addiction, executive function, and the mother-child relationship on emotional dysregulation in early childhood in West Sumatra. This research method is a quantitative survey. The data collection technique in this research uses a questionnaire design on 309 parents who were selected using a simple random sampling method. This data processing

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24

Trabucco, E., A. Vaiarelli, D. Cimadomo, et al. "O-072 Can preimplantation genetic testing for monogenic conditions represent an indication for DuoStim? A multicenter case series." Human Reproduction 37, Supplement_1 (2022). http://dx.doi.org/10.1093/humrep/deac104.086.

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Abstract Study question Is double stimulation in the same ovarian cycle (DuoStim) a valuable strategy to improve the chance of success in couples carrier of monogenic conditions? Summary answer DuoStim is advantageous in patients indicated for preimplantation genetic testing for monogenic diseases and aneuploidy testing (PGT-M/-A) and obtaining ≤5 blastocysts after the I-stimulation. What is known already PGT-M is a well-established strategy to identify unaffected blastocysts in a cohort of embryos produced from couples carrier of single gene disorders. When PGT-M is conducted in poor prognosi

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Du, Mengxi, and Fang Fang Zhang. "Dietary Supplement Use Among Adult Cancer Survivors in the United States." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.168.6.

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BackgroundMany cancer patients initiated supplement use after cancer diagnosis and yet the effect of supplement use on survival has not been established. The trend of and factors associated with dietary supplement use in cancer survivors warrant further investigation.MethodsWe examined the trend of dietary supplemental use in 1,902 adult cancer survivors who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, and compared the frequency of supplement use in cancer survivors to that of 3,804 individuals with no history of cancer who were matched to th

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Hong Son, Bui, Vu Van Nga, Le Thi Diem Hong, and Do Thi Quynh. "Potent Natural Inhibitors of Alpha-Glucosidase and the Application of Aspergillus spp. in Diabetes type 2 Drugs: a Review." VNU Journal of Science: Medical and Pharmaceutical Sciences 38, no. 1 (2022). http://dx.doi.org/10.25073/2588-1132/vnumps.4334.

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Diabetes Mellitus has been becoming a disease of the century, and disease incidence is still rising worldwide. It causes many serious complications, especially in the eye, heart, kidneys, brain, and vascular system, such as diabetic nephropathy, diabetic retinopathy, liver failure, etc. Moreover, the process of controlling this disease is complicated. Meanwhile, the antidiabetic drugs on the market are facing some problems with a wide range of adverse reactions. Therefore, finding new drugs to treat diabetes has always been a topic that many researchers are interested in, especially drugs der

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sprotocols. "Preparation of materials for flexizyme reactions and genetic code reprogramming." January 24, 2015. https://doi.org/10.5281/zenodo.14305.

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Authors: Yuki Goto, Takayuki Katoh & Hiroaki Suga ### Abstract Genetic code reprogramming is a method for the reassignment of arbitrary codons from proteinogenic amino acids to non-proteinogenic ones, and thus specific sequences of non-standard peptides can be ribosomally expressed according to their mRNA templates. We have developed a protocol that facilitates the genetic code reprogramming using flexizymes integrated with a custom-made in-vitro translation apparatus, referred to as the flexible in-vitro translation (FIT) system. Flexizymes are flexible tRNA acylation ribozymes that enabl

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Moustafa, Muhamad. "A Comprehensive Review of Monoclonal Antibodies for the Treatment of Follicular Lymphoma Including Both Approved and Investigational Options." Medical Research Archives 11, no. 11 (2023). http://dx.doi.org/10.18103/mra.v11i11.4745.

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Follicular lymphoma (FL) is the most common type of indolent lymphoma in the Western world, accounting for approximately 30% of lymphoma cases. FL is known for its recurrent nature, necessitating diverse treatment options. The introduction of rituximab, an anti-CD20 antibody, has greatly improved FL outcomes and paved the way for targeted therapies. In this review, we thoroughly explore the structure, mechanism of action, clinical outcomes, and side effects of currently approved monoclonal antibodies (mAb) for FL. Furthermore, we provide insights into ongoing clinical trials and emerging monoc

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sprotocols. "Engineering of ultra-small diagnostic nanoprobes through oriented conjugation of single-domain antibodies and quantum dots." January 7, 2015. https://doi.org/10.5281/zenodo.13799.

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Authors: Alyona Sukhanova, Klervi Even-Desrumeaux, Patrick Chames, Daniel Baty, Mikhail Artemyev, Vladimir Oleinikov & Igor Nabiev ### Abstract Nanoparticle-based biodetection commonly employs monoclonal antibodies (mAbs) for targeting. Although several types of conjugates have been used for biomarker labeling, the large size of mAbs limits the number of ligands per nanoparticle, impedes their intratumoral distribution, and limits intracellular penetration. Furthermore, the conditions of mAb conjugation using conventional techniques provide nanoprobes with irregular orientation of mAbs on

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sprotocols. "Combined 3C-ChIP-Cloning (6C) Assay: A Tool to Unravel Protein-Mediated Genome Architecture." December 30, 2014. https://doi.org/10.5281/zenodo.13582.

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Authors: Vijay K. Tiwari and Stephen B. Baylin Corresponding authors ([sbaylin1@jhmi.edu](sbaylin1@jhmi.edu); [vijay.tiwari@fmi.ch](vijay.tiwari@fmi.ch)) ### INTRODUCTION Progress in technologies to address long-range chromosomal interactions in vivo has extensively revised concepts about different aspects of transcriptional regulation. These methods allow probing physical proximities between chromatin elements without specifically identifying the protein components that mediate such interactions. Here we describe a detailed protocol for Combined 3C-ChIP-Cloning (6C) technology, which combines

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sprotocols. "Combined 3C-ChIP-Cloning (6C) Assay: A Tool to Unravel Protein-Mediated Genome Architecture." December 30, 2014. https://doi.org/10.5281/zenodo.13583.

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Authors: Vijay K. Tiwari and Stephen B. Baylin Corresponding authors ([sbaylin1@jhmi.edu](sbaylin1@jhmi.edu); [vijay.tiwari@fmi.ch](vijay.tiwari@fmi.ch)) ### INTRODUCTION Progress in technologies to address long-range chromosomal interactions in vivo has extensively revised concepts about different aspects of transcriptional regulation. These methods allow probing physical proximities between chromatin elements without specifically identifying the protein components that mediate such interactions. Here we describe a detailed protocol for Combined 3C-ChIP-Cloning (6C) technology, which combines

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sprotocols. "Integration of screening and identifying ligand(s) from medicinal plant extracts based on target recognition by using NMR spectroscopy." January 3, 2015. https://doi.org/10.5281/zenodo.13696.

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Authors: Yalin Tang, Qian Shang, Junfeng Xiang, Qianfan Yang, Qiuju Zhou, Lin Li, Hong Zhang, Qian Li, Hongxia Sun, Aijiao Guan, Wei Jiang & Wei Gai ### Abstract This protocol presents the screening of ligand(s) from medicinal plant extracts based on target recognition by using NMR spectroscopy. A detailed description of sample preparation and analysis process is provided. NMR spectroscopies described here are 1H NMR, diffusion-ordered spectroscopy (DOSY), relaxation-edited NMR, 1H–13C HSQC and HMBC. This method includes three steps: First, investigate the NMR spectroscopy properties of ta

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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Ameku, W.A., V.N. Ataide, E.T. Costab, et al. "A pencil-lead immunosensor for the rapid electrochemical measurement of anti-Diphtheria Toxin antibodies." October 30, 2021. https://doi.org/10.5281/zenodo.5628477.

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<strong>Abstract: </strong>Diphtheria is a vaccine-preventable disease, yet immunization can wane over time to non-protective levels. We have developed a low-cost, miniaturized electroanalytical biosensor to quantify anti-diphtheria toxin (DTx) immunoglobulin G (IgG) antibody to minimize the risk for localized outbreaks. Two epitopes specific to DTx and recognized by antibodies generated post-vaccination were selected to create a bi-epitope peptide, biEP, by synthesizing the epitopes in tandem. The biEP peptide was conjugated to the surface of a pencil-lead electrode (PLE) integrated into a po

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Kojo, Kosuke, Tomoko Oguri, Takazo Tanaka, et al. "Seminal plasma metallomics: a new horizon for diagnosing and managing male infertility." Revista Internacional de Andrología 23, Published Ahead of Print (2025). https://doi.org/10.22514/j.androl.2025.013.

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The authors, Kosuke Kojo and Tomoko Oguri, contributed equally. This HTML edition is publicly accessible at the following URL:https://academic298uro.github.io/open-archive/2025/seminal-plasma-metallomics-new-horizon/ Abstract Seminal plasma contains a wide range of biomolecules—including inorganic elements—that may significantly influence male reproductive function. Historically, semen analysis has focused on sperm count and motility, while overlooking the diagnostic potential of this acellular fraction. This narrative review synthesizes historical perspectives on seminal plasma me

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