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Статті в журналах з теми "159.31 (045)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Caporali, R., D. Aletaha, R. Sanmartí, et al. "POS0682 LONG-TERM EFFICACY OF BARICITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH INADEQUATE RESPONSE TO bDMARDs: RESULTS FROM RA-BEYOND FOLLOWING 6.9 YEARS OF TREATMENT." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 617.2–618. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1759.

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BackgroundBaricitinib (BARI), an oral selective Janus kinase 1/2 inhibitor, is approved for treatment of adults with moderately-to-severely active rheumatoid arthritis (RA). BARI demonstrated efficacy in patients (pts) with RA who have inadequate response to biologic disease-modifying antirheumatic drugs (bDMARD-IR) in a 24-week (wk) phase 3 study, RA-BEACON.1 BARI efficacy was evaluated up to 3 years (yrs) of treatment in a long-term extension (LTE) study, RA-BEYOND.2ObjectivesDisclose long-term efficacy of BARI 4 mg and 2 mg in bDMARD-IR pts in the completed study RA-BEYOND.MethodsIn RA-BEAC

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2

Chryssanthopoulos, Costas, Athanasios Souglis, Sofia Tsalouhidou, et al. "Dietary Intake of Soccer Players before, during and after an Official Game: Influence of Competition Level and Playing Position." Nutrients 16, no. 3 (2024): 337. http://dx.doi.org/10.3390/nu16030337.

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Physical demands in soccer differ according to league level and playing position and may influence nutritional requirements. This study examined the effect of competition level and playing position on dietary intake in male soccer players (SP). Diet was weighed and recorded by 123 SP for 3 days; before, on the day, and the day after an official match. SP in the Super League (SL, n = 33) division reported higher (p < 0.05) average three-day energy (195 ± 36 kJ/kg), carbohydrate (6.0 ± 1.1 g/kg), and protein (2.2 ± 0.5 g/kg) intakes compared to the intakes reported by SP in the 2nd (n = 30) (

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3

ВИЛЬ, Л. Г., and М. М. НИКИТИНА. "COMPARATIVE CHARACTERISTICS OF THE ANDRIANOVSK TYPE GEREFORD BULLS OF DIFFERENT GENEALOGICAL GROUPS ON GROWTH, DEVELOPMENT AND MEAT PRODUCTIVITY." Molochnoe i miasnoe skotovodstvo, no. 2 (April 14, 2022): 34–38. http://dx.doi.org/10.33943/mms.2022.80.89.008.

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Объектом исследований являлись быки-производители герефордской породы Андриановского типа (n=3) и их сыновья (n=10). Опыты проводили с целью оценки роста, развития и мясной продуктивности бычков трех генеалогических групп: сыновей быков-производителей Султана 8019, принадлежащего к родственной группе Сильвина 2862 (I группа), Ямала 5219, относящегося к родственной группе Ракуса 115 (II группа), и Яруса 7715 из родственной группы Руля 31 (III группа). При формировании групп возраст бычков составлял 8 мес, разница по живой массе у подопытных животных была незначительной. В возрасте 15 мес бычки

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4

Kim, Ji Yoon, and Bu Kyung Park. "Perceptions on good death among parents of pediatric patients with hematology-oncology disease in advance." Journal of Clinical Oncology 37, no. 15_suppl (2019): e21532-e21532. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e21532.

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e21532 Background: It is difficult to perceive the preparation of a good death for children because of its social and cultural issues. Among the children with serious diseases, they can be alienated and the whole processes are done by the decision of the parent's proxy even when they have to prepare for death. The purpose of this study was to examine the perception of "Good Death" in advance among parents of pediatric patients with hematology-oncology diseases. Methods: We conducted a cross-sectional survey to parents of pediatric patients in Kyungpook National University Children’s Hospital.

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5

Santa Maria, Peter L., Yangyang Shi, Richard K. Gurgel, et al. "Long-Term Hearing Outcomes Following Stereotactic Radiosurgery in Vestibular Schwannoma Patients—A Retrospective Cohort Study." Neurosurgery 85, no. 4 (2018): 550–59. http://dx.doi.org/10.1093/neuros/nyy407.

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AbstractBACKGROUNDAn understanding of the hearing outcomes is needed for treatment counseling for patients with vestibular schwannomas (VS).OBJECTIVETo determine long-term hearing results following stereotactic radiosurgery (SRS) for VS and identify any influential variables.METHODSTertiary hospital retrospective cohort.RESULTSThere were 579 tumors (576 patients) treated with SRS. Eighty-two percent (473) of tumors had ≥1 yr and 59% (344 ≥3 yr follow-up. In the 244 tumor ears, with measurable hearing before SRS who were followed ≥1 yr, 14% (31) had improved hearing, 13% (29) unchanged hearing,

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6

Pimenta, A. D., and L. R. L. Simone. "Morphology of two deep-sea Olivella from the southwestern Atlantic, with a record of a radula-less Olivellinae species (Neogastropoda: Olivoidea: Olividae) doi:0.1127/arch.moll/150/031-043." Archiv für Molluskenkunde International Journal of Malacology 150, no. 1 (2021): 31–43. http://dx.doi.org/10.1127/arch.moll/150/2021/31.

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7

REHMAN, Shams Ur, Uzair AHMED, Ayesha ZAHOOR, et al. "FOLIAR ZINC AND SOIL APPLIED MOLYBDENUM OPTIMIZE YIELD AND DRY MATTER PARTITIONING OF LENTIL." Journal of Applied Life Sciences and Environment 57, no. 1(197)2024 (2024): 123–36. http://dx.doi.org/10.46909/alse-571127.

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A field experiment on the effect of zinc and molybdenum application on the yield of lentil was carried out at The University of Agriculture Peshawar during the Rabi season of 2021. The experiment was carried out in a randomised complete block design with three replications. Four levels of molybdenum (0, 1, 2 and 3 kg ha−1) and 0.5% zinc foliar spray at different intervals of lentil crop (control, 50 days after sowing, 100 days after sowing, 50 days after sowing + 100 days after sowing) were tested in the experiment. The results revealed that 3 kg ha−1 of molybdenum enhanced plant height (55 cm

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8

Wang, Feige, Jinyi Yang, Xiaohui Fan, et al. "A Spatially Resolved [C ii] Survey of 31 z ∼ 7 Massive Galaxies Hosting Luminous Quasars." Astrophysical Journal 968, no. 1 (2024): 9. http://dx.doi.org/10.3847/1538-4357/ad3fb4.

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Abstract The [C ii] 158 μm emission line and the underlying far-infrared (FIR) dust continuum are important tracers for studying star formation and kinematic properties of early galaxies. We present a survey of the [C ii] emission lines and FIR continua of 31 luminous quasars at z > 6.5 using the Atacama Large Millimeter Array (ALMA) and the NOrthern Extended Millimeter Array at sub-arcsec resolution. This survey more than doubles the number of quasars with [C ii] and FIR observations at these redshifts and enables statistical studies of quasar host galaxies deep into the epoch of reionizat

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9

Schulman, Sam, Henry Eriksson, Ajay Kakkar, et al. "Influence of Age and Renal Function on Efficacy and Safety of Dabigatran Versus Warfarin for the Treatment of Acute Venous Thromboembolism: A Pooled Analysis of RE-COVER™ and RE-COVER™ II." Blood 124, no. 21 (2014): 594. http://dx.doi.org/10.1182/blood.v124.21.594.594.

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Abstract Background: In the RE-COVER™ and RE-COVER™ II trials, dabigatran etexilate (DE) was as effective as warfarin (W) for prevention of recurrent venous thromboembolism (VTE) in patients with acute VTE, and was associated with a lower risk of bleeding. Objectives: Older patients and patients with renal impairment may be at greater risk of bleeding and/or VTE. In this post-hoc analysis of the pooled dataset from RE-COVER™ and RE-COVER™ II, we assessed rates of VTE recurrence and bleeding with DE and W in patients below and above 75 years according to renal function (normal, or mildly or mod

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10

Trinh, Phan Thi Hoai, Ngo Thi Duy Ngoc, Phi Quyet Tien, et al. "Antibacterial activity of marine bacteria associated with sponges from Phu Quoc island in Vietnam." Vietnam Journal of Biotechnology 14, no. 1 (2016): 181–90. http://dx.doi.org/10.15625/1811-4989/14/1/9308.

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Sponge associated marine microbes recognised as potential candidate for screening and isolation of bioactive compounds. In this work, thirty-one marine bacterial strains associated with seven species of sponges collected from Phu Quoc Island, Vietnam were isolated and screened for antimicrobial activity against selected human and animal pathogens including Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Vibrio parahaemolyticus, Vibrio harveyi, Bacillus cereus, Streptococcus faecalis, Listeria monocytogenes, Proteus mirabilis and Klebsiella pneumoniae using agar well diffusion

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11

Stiff, Patrick J., Ivana NM Micallef, Auayporn P. Nademanee, et al. "Transplanted CD34+ Cell Dose Is Associated with Long-Term Platelet Count Following Autologous Hematopoietic Stem Cell Transplant in Patients with Non-Hodgkin’s Lymphoma and Multiple Myeloma." Blood 112, no. 11 (2008): 2175. http://dx.doi.org/10.1182/blood.v112.11.2175.2175.

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Abstract Introduction: The impact of transplanted CD34+ cell dose on clinical outcomes remains controversial. The purpose of this study was to examine the relationship between CD34+ cell dose transplanted and platelet, neutrophil, and lymphocyte counts at 100 days, 6, and 12 months following autologous transplantation in patients with non-Hodgkin’s lymphoma (NHL) and multiple myeloma (MM). Methods: Data were obtained from two phase 3 clinical studies that compared the safety and efficacy of plerixafor and G-CSF with placebo and G-CSF in mobilization of hematopoietic blood stem cells for autolo

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12

Marczyk, Vicente Rodrigues, Sarah Hamidi, Mark Zafereo, et al. "Abstract LB414: Characterization of the genomic landscape of BRAF-, RAS-, and fusion-negative thyroid carcinomas underscores the role of tumor suppressor genes." Cancer Research 85, no. 8_Supplement_2 (2025): LB414. https://doi.org/10.1158/1538-7445.am2025-lb414.

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Abstract Background: Most non-medullary thyroid carcinomas (TC) are driven by mutually exclusive BRAF/RAS pathogenic variants or fusions involving RET, NTRK1/3, ALK, BRAF, or PPARG. However, none of these alterations are found in a subset of thyroid carcinomas (hereafter triple-negative TC). Methods: Patients within GENIE AACR (v16.0) with papillary (PTC), follicular (FTC), oncocytic (OTC), poorly-differentiated (PDTC), and anaplastic (ATC) thyroid carcinoma who underwent NGS testing for somatic mutations and fusions were included. We used Fisher exact test to compare the frequency of somatic

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13

Bowmaker, Graham A., Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. I Large-Cation (2,2′-Bipyridinium and 1,10-Phenan- throlinium) Salts of Polyhalobismuthate(III) Ions." Australian Journal of Chemistry 51, no. 4 (1998): 293. http://dx.doi.org/10.1071/c97036.

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Syntheses and room-temperature single-crystal X-ray studies are recorded for a variety of salts of cations derived from protonated 2,2′-bipyridine and 1,10-phenanthroline (bpyH+ and phenH+) with polyhalobismuthate(III) anions. ‘[(phenH)(phenH2)(H2O)2] [BiCl6]’ is triclinic, P-1, a 9·791(1), b 9·338(3), c 8·311(3) Å, α 73·46(3), β 69·71(2), γ 86·36(2)°, Z = 1; conventional R on |F| was 0·027 for No 4852 independent ‘observed’ (I > 3σ(I)) reflections. [BiCl6]3- is closely octahedral, accompanied by an interesting protonation/hydrogen-bonding array among the other moieties. The latter comment

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14

SAHA, KOUSHIK, HARSHAWARDHAN CHOUDHARY, A. D. MUNSHI, and A. K. SINGH. "Heterosis and combining ability for yield traits and its relationship with gene action in muskmelon (Cucumis melo)." Indian Journal of Agricultural Sciences 92, no. 5 (2022): 602–6. http://dx.doi.org/10.56093/ijas.v92i5.124701.

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Twenty-one F1 hybrids were developed from seven diverse parental lines of muskmelon (Cucumis melo L.) from two horticultural groups, viz. inodorous and cantalupensis through half-diallel mating system and evaluated at ICARIndian Agricultural Research Institute, New Delhi, during 2017 and 2018. The component of variance for sca (σ2s) was higher than gca component of variance (σ2g) for all the characters, except average fruit weight, which indicated the importance of non-additive gene action for improvement of many traits. The predictability ratio and average degree of dominance was less than 0.

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15

Shojania, A. Majid. "Improvement of Myelodysplasia and Partial Correction of panhypogammaglobulinemia after IV IgG Infusions and Splenectomy." Blood 112, no. 11 (2008): 5105. http://dx.doi.org/10.1182/blood.v112.11.5105.5105.

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Abstract A man born in 1951 underwent a bone marrow examination, on May 10, 1991, for investigation of his pancytopenia. The bone marrow slides were sent to me for interpretation. I made the diagnosis of myelodysplasia (refractory anemia without excess blast). The patient was subsequently referred to a hematologist in another hospital for further investigation and management. A repeat bone marrow aspiration and biopsy on May 30, 1991 again demonstrated myelodysplasia. Bone marrow biopsy, flow cytometry and cytogenetic studies were normal. His Hgb was 124 G/L, WBC 2.2 and platelet (Plt) 151 × 1

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16

Cywińska, A., M. Czopowicz, L. Witkowski, et al. "Reference intervals for selected hematological and biochemical variables in Hucul horses." Polish Journal of Veterinary Sciences 18, no. 2 (2015): 439–45. http://dx.doi.org/10.1515/pjvs-2015-0056.

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Abstract Background: Hucul horses are the unique, genetically distinct breed of Carpathian Mountains. Even though they are recognized as primitive breed, many morphological differences between them and other primitive horses have been reported. Neither hematological nor blood biochemical studies in this breed have been conducted so far. Objectives: The aim of this study was to establish the reference intervals for basic hematological and selected biochemical variables and to compare them with other breeds. Material and Methods: Blood samples were collected from 168 Hucul horses and the analyse

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17

Hamzah, Muhaimin, Muhammad Agus Suprayudi, Nur Bambang Priyo Utomo, and Wasmen Manalu. "Growth and viability of juvenile humpback grouper (Cromileptes altivelis) supplemented with inorganic and organic selenium." Jurnal Akuakultur Indonesia 11, no. 2 (2013): 141. http://dx.doi.org/10.19027/jai.11.141-152.

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<p>This study was conducted to determine the effects of inorganic selenium (sodium selenite) and organic selenium (selenomethionine) supplementation on growth and viability of juvenile humpback grouper (Cromileptes altivelis). The experiment was designed as a completely randomized design with eight treatments and three replications. The treatment being tested was source and dosages of selenium ie., inorganic selenium (sodium selenite) supplementation with dosages of 0.5, 1, 2, and 4 mg Se/kg diet and organic selenium (selenomethionine) with dosages of 1, 2, and 4 mg Se/kg diet. Another t

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18

Ríos, Miguel A., and Jesús Rodríguez. "Ab initio study of the structure of the hydrogen maleate anion." Canadian Journal of Chemistry 71, no. 3 (1993): 303–6. http://dx.doi.org/10.1139/v93-044.

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The hydrogen maleate ion was studied by ab initio methods with complete optimization at the 3-21G, 6-31G, 6-31G**, and 6-31+G(2d,1p) levels. To study the influence of electron correlation, MP2 calculations have been done for the 6-31G** geometry. All calculations at the HF level predicted an asymmetric hydrogen bond with a double minimum potential governing transfer between the two equivalent structures. Moreover, both asymmetry and proton transfer barrier increase systematically with the power of the basis set used, with calculated barrier heights of 0.12 (3-21G), 1.59 (6-31G), 1.64 (6-31G**)

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19

Du, Peter Z., Keith L. Markolf, Christopher J. Lama, David R. McAllister, and Kristofer J. Jones. "Contact Forces Acting on Large Femoral Osteochondral Allografts During Forced Knee Extension." American Journal of Sports Medicine 45, no. 12 (2017): 2804–11. http://dx.doi.org/10.1177/0363546517715726.

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Background: A single cylindrical graft plug is commonly used for large focal femoral defects during osteochondral allograft (OCA) transplantation. Excessive contact force (CF) on a proud plug could compromise initial healing. CFs during forced knee extension are of particular interest because this maneuver is used by therapists to restore early postoperative range of motion. Hypothesis: A proud OCA plug will significantly increase the CF and significantly decrease the knee extension angle (KEA). Study Design: Controlled laboratory study. Methods: Eleven human knee specimens had miniature load

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20

Порсев, Игорь Николаевич, Валентина Владимировна Половникова, Валерия Валерьевна Черткова та Егор Владимирович Низавитин. "Значение сортов и протравителей в фитосанитарной технологии возделывания яровой пшеницы в Зауралье". АПК России 31, № 1 (2024): 24–31. http://dx.doi.org/10.55934/2587-8824-2024-31-1-24-31.

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Цель исследования заключалась в выявлении устойчивых сортов мягкой яровой пшеницы к корневой гнили и возможности применения современных протравителей семян в фитосанитарной технологии возделывания Зауралья. Значительное развитие корневых инфекций в почвах Зауралья обусловлено высокой насыщенностью севооборотов восприимчивыми к ним культурами. Инфекционный потенциал возбудителя корневой гнили Bipolaris sorokiniana в почве по результатам наших исследований достигал 2,1–7,5 ПВ. Условия вегетации в годы исследования были остро засушливыми, гидротермический коэффициент вегетационного периода изменя

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21

Khonyoung, Duddoa, Koh-en Yamauchi, Tonglian Buwjoom, Buaream Maneewan, and Narin Thongwittaya. "Effects of dietary dried fermented ginger on growth performance, carcass quality, and intestinal histology of heat-stressed broilers." Canadian Journal of Animal Science 92, no. 3 (2012): 307–17. http://dx.doi.org/10.4141/cjas2011-129.

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Khonyoung, D., Yamauchi, K., Buwjoom, T., Maneewan, B. and Thongwittaya, N. 2012. Effects of dietary dried fermented ginger on growth performance, carcass quality, and intestinal histology of heat- stressed broilers. Can. J. Anim. Sci. 92: 307–317. To investigate the effects of a dried fermented ginger product (DFG) on growth performance, carcass quality, and intestinal histology of heat-stressed broiler, at 7 d of age, 200 male broilers were divided into 0% (control), 0.25% (0.25 S+F), 0.5% (0.5 S+F) and 1% (1 S+F) dietary DFG groups fed from 7 to 49 d of age (starter+finisher groups, S+F). A

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22

Boyce, Amanda C., Karen J. Gibson, E. Marelyn Wintour, et al. "The kidney is resistant to chronic hypoglycaemia in late-gestation fetal sheep." Canadian Journal of Physiology and Pharmacology 85, no. 6 (2007): 597–605. http://dx.doi.org/10.1139/y07-047.

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We imposed a sustained reduction in glucose supply to late-gestation fetal sheep to see whether the reduction in glucose and insulin levels affected renal growth, renin expression and synthesis, and renal function. Maternal glucose concentrations were lowered to 1.7–1.9 mmol/L for 12–13 days by i.v. insulin infusion (n = 9, 121 days gestation, term = 150 days). Control ewes (n = 7) received vehicle. Maternal and fetal glucose concentrations were 40% and 31% lower than in controls (p < 0.001), respectively. Fetal plasma insulin levels fell 36% ± 7% by day 7 (p < 0.05); IGF-I levels were u

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23

Stetsiuk, Aleksandra Petrovna, Natalya Stanislavovna Kuz'minova, and Tatyana Vadimovna Viter. "Mercury distribution in tissues of black sea gobiids from the coastal zone of Sevastopol." Toxicological Review 31, no. 2 (2023): 109–19. http://dx.doi.org/10.47470/0869-7922-2023-31-2-109-119.

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Introduction. Marine aquatic organisms, especially with nutritional value, accumulate pollutants from the environment and therefore must be constantly monitored for toxic elements content. Mercury, even in inorganic form and in sub-lethal amounts, is a risk factor for aquatic biota.  The aim of the work is to measure mercury concentrations in the tissues of the Black Sea gobies; identification of species accumulating mercury to a greater or lesser extent, as well as intraspecific features of mercury accumulation. Material and methods. Muscles, liver and gills of Black Sea goby fish

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24

Guimaraens, Leopoldo, Elio Vivas, Jesus Saldaña, et al. "Efficacy and safety of the dual-layer flow-diverting stent (FRED) for the treatment of intracranial aneurysms." Journal of NeuroInterventional Surgery 12, no. 5 (2019): 521–25. http://dx.doi.org/10.1136/neurintsurg-2019-015371.

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PurposeTo describe the efficacy and complications of treating cerebral aneurysms with the Flow Re-direction Endoluminal Device (FRED) and to identify predictors for aneurysm occlusion.MethodsA prospective observational registry including all consecutive aneurysms treated with FRED between December 2015 and July 2018 was designed in one therapeutic neuroangiography department. The primary endpoint for treatment efficacy was complete or near-complete occlusion (O’Kelly–Marotta (OKM) C–D), assessed by three-dimensional digital subtraction angiography. Major (all symptomatics) and minor complicati

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25

ZUBACH, OLENA, OKSANA SEMENYSHYN, LILYA VASIUYNETS, OKSANA VELYCHKO, and ALEXANDER ZINCHUK. "Application of PCR for Specific Diagnosis of Leptospirosis in Humans in Ukraine." Polish Journal of Microbiology 69, no. 4 (2020): 421–26. http://dx.doi.org/10.33073/pjm-2020-045.

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Leptospirosis remains one of the most widespread zoonotic diseases in the world and Ukraine, in particular. Ukrainian clinicians have been faced with early detection of the disease due to the availability of only a serological method for routine diagnostics in Ukraine, namely the microscopic agglutination test (MAT). This paper demonstrates the first results of the complex application of MAT and polymerase chain reaction (PCR) for routine verification of leptospirosis, which were first applied simultaneously in Lviv Oblast of Ukraine in 2016. We examined the sera of 150 patients clinically sus

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26

RUDZITE, A. M., D. AUZINA, and S. LEJNIECE. "FACTORS AFFECTING COVID-19 OUTCOMES IN PATIENTS WITH HEMATOLOGICAL MALIGNANCIES." Experimental Oncology 46, no. 3 (2024): 260–67. https://doi.org/10.15407/exp-oncology.2024.03.260.

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Background. Patients with hematological malignancies (HM) are considered to have a high risk of developing severe and life-threatening infections including COVID-19 because of immune deficiency and immunosuppressive treatments. Although the COVID pandemic spread worldwide, morbidity and mortality data varied from country to country. A more accurate identification of risk factors would allow the improvement of the clinical management of HM patients. Aim. This study aimed to determine real-life data — the mortality rate, clinical outcomes, and risk factors affecting mortality in patients with HM

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Стельмах, Виктория Валерьевна, Игорь Геннадьевич Бакулин, Алексей Леонидович Коваленко та Виктор Константинович Козлов. "Эффективность ремаксола у пациентов с алкогольной болезнью печени". Экспериментальная и клиническая фармакология 85, № 6 (2022): 25–31. http://dx.doi.org/10.30906/0869-2092-2022-85-6-25-31.

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Обследовано 85 пациентов с алкогольной болезнью печени (АБП) в возрасте от 24 до 70 лет. Пациенты основной группы (n = 50) в составе комплексной терапии получали ремаксол: ежедневно (10 – 12 дней) внутривенно капельно по 400 мл 1 раз в сутки; пациентам группы сравнения (n = 35) вводили адеметионин (800 мг, внутривенно) 1 раз в сутки в течение 10 – 12 дней. Включение ремаксола в комплексное лечение пациентов с АБП на цирротической стадии способствовало улучшению компенсаторных возможностей печени и краткосрочного жизненного прогноза: в 2,3 раза уменьшилось количество больных со значением расчет

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Cho, Bin, Sun Young Kim, Dae Hyoung Lee, et al. "Gemtuzumab Ozogamicin with FLAG-IDA Is Effective for Children in Relapsed/Refractory Acute Myeloid Leukemia." Blood 108, no. 11 (2006): 4556. http://dx.doi.org/10.1182/blood.v108.11.4556.4556.

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Abstract Background: Several approaches using antibodies to CD33 in the treatment of relapsed or refractory AML have been attempted, including the use of gemtuzumab ozogamicin. We decided to conduct a pilot study in pediatric patients with CD33 positive relapsed or refractory AML of targeted immunotherapy with GO combined with FLAG-IDA, to determine whether this combination would be effective and well tolerated. Patients and Methods: Eligibility criteria included CD33 positive relapsed or refractory AML and baseline serum bilirubin and creatinine ≤ 1.5 mg/ml. The patients received GO on day 1

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Kurniasari, Pitaloka, Iwan Sahrial Hamid, and Mirza Atikah Madarina Hisyam. "The Effectiveness of Basil Leaves Extract (Ocimum basilicum L.) on Histopathological Features of The Lung Rattus Norvegicus Exposure to Mosquito Coil Smoke." Journal of Applied Veterinary Science And Technology 6, no. 1 (2025): 27–31. https://doi.org/10.20473/javest.v6.i1.2025.27-31.

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Background: Mosquito coil smoke is one of the exogenous free radicals. Exposure to mosquito coil smoke is associated with lung inflammation, oxidative stress and lipid peroxidation. Compounds that can inhibit the oxidation reaction by binding free radicals are known as antioxidants. Purpose: This study aims to determine the effectiveness of basil leaf extract (Ocimum basilicum L.) as an antioxidant on damage to the histological structure of the lung of white rats (Rattus norvegicus) exposed to mosquito coil smoke. Method: Rats were divided into five groups; group without treatment as negative

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Kovalyshyna, Hanna, Yuliia Dmytrenko, Oleksandr Makarchuk, Natalia Slobodyanyuk, and Mikhailo Mushtruk. "The donor properties of resources resistance against the exciter of wheat rust wheat." Potravinarstvo Slovak Journal of Food Sciences 14 (September 28, 2020): 821–27. http://dx.doi.org/10.5219/1427.

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A collection of soft winter wheat specimens investigated on the artificial infectious background of the leaf rust pathogen and selected resistance among them. The genetics of resistance sign in varieties and specimens were determined by hybridological analysis of F2: Lovrin 32, KM 1485-6-8, VR 89 Bo 22, Beres, Tobarzo, 0-74-8-2, MIKM 1851-80, 4347-4, NS 326-99, 5517 A-5-5 Yr, Florida 302, VR 87 Bo 15, Matyo, NS 1308, 200-830, Polka, NS 2630/1, NS 18-30, HBE 0140-119, HBE 208-120, HBE 0303 156, HBE 0425-156, Tx91v4511, Tx92v4511, Plyska, Zernogradskaya 31, Volshebnitsa, Myronivska 40, Myronivsk

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Alexander, Melissa, Jessica Beyda, Anupma Nayak, and Shabnam Jaffer. "Not All Ductal Carcinomas In Situ Are Created IDLE (Indolent Lesions of Epithelial Origin)." Archives of Pathology & Laboratory Medicine 143, no. 1 (2018): 99–104. http://dx.doi.org/10.5858/arpa.2017-0366-oa.

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Context.— Mammographic screening has increased the incidence of ductal carcinoma in situ (DCIS), but this has not been accompanied by a decline in the incidence of invasive carcinoma (IC). Consequently, the surgical treatment of DCIS has recently been questioned, with some advocating only surveillance (with or without neoadjuvant endocrine therapy) after a core biopsy diagnosis of DCIS. Objectives.— To examine the predictive value of a core biopsy diagnosis of DCIS, particularly the upgrade rate to IC, and to identify associated factors. Design.— Using the pathology database, we identified 294

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M., A. QURAISHI, та N. DHAWAN S. "Synthesis and Mass Spectral Studies of Ketimines. Part-I. Fragmentation of some New α-( 1 ,3-Dioxoindan2-yl)ethylidene/ arylideneanilines under Electron Impact". Journal of Indian Chemical Society Vol. 66, June 1989 (1989): 387–89. https://doi.org/10.5281/zenodo.5959588.

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Department of Chemistry, Institute of Technology, Banaras Hindu University, Varanasi-221 005 Department of Chemistry, University of Kurukshetra, Kurukshetra-132 119 <em>Manuscript received 26 October 1988, revised 27 January 1989, accepted 31 March 1989</em> Condensation of 2-acylindan-1,3-diones (1) with anilines afforded the corresponding anils (2a-j) which <em>were </em>characterised by elemental analyses and ir and pmr spectral data. Electron impact mass fragmentation of these anils is <em>reported.</em>

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Moore, Colin Edward, and Elod L. Gyenge. "Tuning the Composition of Bimetallic Electrodeposited Sn-Pb Catalysts for Enhanced Activity and Durability in CO₂ Electroreduction to Formate." ECS Meeting Abstracts MA2018-01, no. 31 (2018): 1829. http://dx.doi.org/10.1149/ma2018-01/31/1829.

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Efficient and durable catalysts are needed to convert CO2 to value added products. In recent years, extensive research has been done on tin (Sn) because of its high faradaic efficiency for producing formate (HCOO-) from CO2 [1–5] and lead (Pb) because of its high hydrogen evolution (HER) overpotential [4, 6]. In our recent study [7], bimetallic Sn-Pb catalysts with five different Sn/Pb atomic ratios were electrodeposited on Teflonated carbon paper and non-Teflonated carbon cloth using both metal fluoroborate- and metal oxide-containing deposition media to produce catalysts for electrochemical

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Edslev, Pernille Wendtland, Jonas Abrahamsson, Niels Clausen, et al. "Age and Prognosis in Pediatric AML." Blood 112, no. 11 (2008): 2990. http://dx.doi.org/10.1182/blood.v112.11.2990.2990.

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Abstract Introduction. Results from St. Jude and M. D. Anderson, USA, suggested that AML children &lt; 10 years have significantly better outcome than patients aged 10–21 years. Similarly, the Medical Research Council, UK, showed superior survival in children &lt; 10 years due to a lower relapse rate compared to 10 – 15 year olds. We describe the AML outcome by age in the Nordic countries. Patients. Within the population based NOPHO AML protocols (NOPHO-AML 93 and NOPHO-AML 2004) we treated 403 patients aged 0 – 18 years from 1993 – 2007. Patients with Down syndrome and AML-M3 were exc

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Gupta, Sudeep, Senthil Rajappa, Suresh Advani, et al. "Prevalence of BRCA1 and BRCA2 Mutations Among Patients With Ovarian, Primary Peritoneal, and Fallopian Tube Cancer in India: A Multicenter Cross-Sectional Study." JCO Global Oncology, no. 7 (June 2021): 849–61. http://dx.doi.org/10.1200/go.21.00051.

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PURPOSE There are deficient data on prevalence of germline mutations in breast cancer susceptibility genes 1 and 2 ( BRCA1/ BRCA2) in Indian patients with ovarian cancer who are not selected by clinical features. METHODS This prospective, cross-sectional, noninterventional study in nine Indian centers included patients with newly diagnosed or relapsed epithelial ovarian, primary peritoneal, or fallopian tube cancer. The primary objective was to assess the prevalence of BRCA1/ BRCA2 mutations, and the secondary objective was to correlate BRCA1/ BRCA2 status with clinicopathologic characteristic

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Mehofer, M., B. Schmuckenschlager, N. Vitovec, et al. "Freilanduntersuchungen zum Einfluss von 31 Unterlagsrebsorten auf Ertrag und ausgewählte Qualitätsparameter der Rebsorte “Zweigelt”." BIO Web of Conferences 12 (2019): 01014. http://dx.doi.org/10.1051/bioconf/20191201014.

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Auf einem Standort mit carbonathältiger Braunerde auf Flyschmergel wurde bei der Sorte “Zweigelt” der Einfluss von 31 Unterlagsrebsorten auf die Parameter Mostgewicht, Säuregehalt des Mosts, Ertrag, Traubengewicht und Schnittholzgewicht ermittelt. Im Durchschnitt der zwölf Versuchsjahre bewirkten die Unterlagen 41 B, Ru 140 und G 9 eine signifikante Reduktion des Mostgewichts um 0.47∘ KMW, 0.26∘ KMW und 1.13∘ KMW im Vergleich zu K 5BB. Bei den Unterlagen 1616 C und 3309 C war das Mostgewicht mit + 0.4∘ KMW und + 0.34∘ KMW hingegen signifikant höher. Die Jahresmittelwerte des Mostgewichtes lage

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Alpizar-Rodriguez, D., F. Irazoque-Palazuelos, T. S. Rodriguez-Reyne, et al. "POS1242 FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS WITH RHEUMATIC DISEASES AND COVID-19 IN MEXICO." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 904.1–904. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3342.

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Background:As of the 25th of January 2021, more than 150 thousand deaths as consequence of COVID-19 have been reported in Mexico [1]. Advanced age, male gender and comorbidities have been described as risk factors for severe disease and mortality in general population [2]. COVID-19 mortality in Mexican patients with rheumatic and musculoskeletal diseases (RMDs) is unknown.Objectives:To describe characteristics of Mexican patients with RMDs and COVID-19, and to analyse factors associated with mortality.Methods:The Global Rheumatology Alliance COVID-19 (GRA) physician reported registry, is an in

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Rutledge, Lesley R., and Stacey D. Wetmore. "The assessment of density functionals for DNA–protein stacked and T-shaped complexes." Canadian Journal of Chemistry 88, no. 8 (2010): 815–30. http://dx.doi.org/10.1139/v10-046.

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The present work uses 129 nucleobase – amino acid CCSD(T)/CBS stacking and T-shaped interaction energies as reference data to test the ability of various density functionals with double-zeta quality basis sets, as well as some semi-empirical and molecular mechanics methods, to accurately describe noncovalent DNA–protein π–π and π+–π interactions. The goal of this work is to identify methods that can be used in hybrid approaches (QM/MM, ONIOM) for large-scale modeling of enzymatic systems involving active-site (substrate) π–π contacts. Our results indicate that AMBER is a more appropriate choic

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Lapierre, Valerie, Christian Chabannon, Caroline Makowski, et al. "Ancestim (r-metHuSCF) Plus Filgrastim for the Mobilization and Collection of Peripheral Blood Progenitor Cells for Autologous Transplant after Failure of Prior Mobilization: The French Experience of Compassionate Use." Blood 110, no. 11 (2007): 3281. http://dx.doi.org/10.1182/blood.v110.11.3281.3281.

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Abstract Background: Ancestim (r-met human stem cell factor; Amgen Inc, CA, USA) is available in France for compassionate use in patients who have failed prior mobilization or an insufficient number of CD34+ cells for autograft. We retrospectively reviewed data from these patients to evaluate the efficacy of ancestim combined with filgrastim in achieving an adequate stem cell yield. Patients and methods: Between January 1998 and July 2007, permission for ancestim use was granted by the French health authority and Amgen to 550 patients (pts) at 82 sites (median age 55 yrs (range, 18–74); 50% ma

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Suzuki, Hiroyuki, Ian Kidder, Tomohiro Tanaka, and Michihiko Goto. "Incidence of Colorectal Cancer in Patients Diagnosed With Pyogenic Liver Abscess." JAMA Network Open 6, no. 12 (2023): e2348218. http://dx.doi.org/10.1001/jamanetworkopen.2023.48218.

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ImportanceColorectal cancer (CRC) can compromise the mucosal barrier and subsequently allow a route for bacterial invasion into the portal system or systemic circulation. Despite preliminary data suggesting that patients who experienced pyogenic liver abscess (PLA) have higher CRC incidence rates, data from outside the Southeast Asian population are sparse.ObjectiveTo investigate whether there is an association between PLA and the subsequent incidence of diagnosed CRC using the Veterans Health Administration (VHA) cohort.Design, Setting, and ParticipantsA patient-level matched retrospective co

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Reyes, Carlen, Andrea Pistillo, Sergio Fernández-Bertolín, et al. "Characteristics and outcomes of patients with COVID-19 with and without prevalent hypertension: a multinational cohort study." BMJ Open 11, no. 12 (2021): e057632. http://dx.doi.org/10.1136/bmjopen-2021-057632.

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ObjectiveTo characterise patients with and without prevalent hypertension and COVID-19 and to assess adverse outcomes in both inpatients and outpatients.Design and settingThis is a retrospective cohort study using 15 healthcare databases (primary and secondary electronic healthcare records, insurance and national claims data) from the USA, Europe and South Korea, standardised to the Observational Medical Outcomes Partnership common data model. Data were gathered from 1 March to 31 October 2020.ParticipantsTwo non-mutually exclusive cohorts were defined: (1) individuals diagnosed with COVID-19

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Macdonald, C. R., and C. D. Metcalfe. "Concentration and Distribution of PCB Congeners in Isolated Ontario Lakes Contaminated by Atmospheric Deposition." Canadian Journal of Fisheries and Aquatic Sciences 48, no. 3 (1991): 371–81. http://dx.doi.org/10.1139/f91-049.

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The concentration of 19 PCB congeners was analysed in biota, sediments, water, and suspended solids in four central Ontario lakes in which atmospheric deposition was the major source of PCB contamination. Input from the atmosphere resulted in total congener concentrations of 1–2 ng∙L−1 dissolved in water, 10–50 μg∙kg−1 (dry weight} in sediment, 5–10 μg∙kg−1 (wet weight) in biota from lower trophic levels (i.e. zooplankton, golden shiner (Notemigonus crysoleucas)), and 10–30 μg∙kg−1 (wet weight) in fish from upper trophic levels (yellow perch (Perca fiavescens), smallmouth bass (Micropterus dol

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Kulkarni, Meghana, Simon Hughes, Andrew Mallia, et al. "The management impact of 68gallium-tris(hydroxypyridinone) prostate-specific membrane antigen (68Ga-THP-PSMA) PET-CT imaging for high-risk and biochemically recurrent prostate cancer." European Journal of Nuclear Medicine and Molecular Imaging 47, no. 3 (2019): 674–86. http://dx.doi.org/10.1007/s00259-019-04643-7.

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Abstract Purpose To determine the impact on clinical management of patients with high-risk (HR) prostate cancer at diagnosis and patients with biochemical recurrence (BCR) using a new kit form of 68Ga-prostate-specific membrane antigen (PSMA), namely tris(hydroxypyridinone) (THP)-PSMA, with positron emission tomography-computed tomography (PET-CT). Methods One hundred eighteen consecutive patients (50 HR, 68 BCR) had management plans documented at a multidisciplinary meeting before 68Ga-THP-PSMA PET-CT. Patients underwent PET-CT scans 60-min post-injection of 68Ga-THP-PSMA (mean 159 ± 21.2 MBq

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Sharafutdinov, A. A., A. V. Krasnov, and A. M. Gazizov. "Study of the Behavior of Wall Sandwich Panels Irrigated with a Drencher Curtain at the Unilateral Thermal Exposure." Occupational Safety in Industry, no. 2 (February 2022): 27–31. http://dx.doi.org/10.24000/0409-2961-2022-2-27-31.

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In the last ten years, drencher curtains are widely used at the large production facilities to increase fire resistance of the building structures. The length of the drencher curtains used as a compensating measure instead of fire walls can reaches 250 m. A three-dimensional modeling of the operation of a drencher curtain together with a type 1 fire barrier in the form of a sandwich panel was performed. FireCat software package was used for modeling. One of its components is the PyroSim software package designed for fire modeling. A field model was chosen as a mathematical model of fire develo

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Bond, Howard E., Steven D. Kawaler, and Robin Ciardullo. "Asteroseismology of Planetary Nuclei." Symposium - International Astronomical Union 180 (1997): 97–98. http://dx.doi.org/10.1017/s0074180900129882.

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The first two pulsating planetary-nebula nuclei (PNNs), those of K 1-16 and Lo 4, were discovered by Grauer & Bond (1984) and Bond & Meakes (1990). They are nonradial multiperiodic g-mode pulsators, with typical periods near 25–31 min and low amplitudes (up to ∼ 0.05–0.1 mag). These PNNs have extremely high temperatures (Teff > 100,000 K), and are hydrogen-deficient with high abundances of C and O. Their spectra and pulsational properties are very similar to those of the pulsating GW Vir (PG 1159–035) white dwarfs.

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Jordy, Sergio Semeraro, Charles Peter Tilbery, and Mirella Martins Fazzito. "Immunomodulator therapy migration in relapsing remitting multiple sclerosis: a study of 152 cases." Arquivos de Neuro-Psiquiatria 66, no. 1 (2008): 11–14. http://dx.doi.org/10.1590/s0004-282x2008000100004.

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BACKGROUND: Since 1997, immunological modulators have been used for treatment of Relapsing Remitting Multiple Sclerosis (RRMS) in the Multiple Sclerosis Attendance and Treatment Center (CATEM) with significant alterations in this disease natural history. AIM: To add data on the experience of CATEM for the treatment of RRMS patients that had immunomodulators. METHOD: RRMS patients that received continuously immunomodulator drugs were evaluated on adherence, migration, withdrawal and progression rates. The patients were divided in three groups by the period of immunomodulators intake. RESULTS: T

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Nguyen Thi Phuong, Mai, Huong Nguyen Thi Thu, Khiem Nguyen Viet, et al. "Simultaneous determination of some coccidiostat antibiotics in food by liquid chromatography tandem mass spectrometry (LC-MS/MS)." Heavy metals and arsenic concentrations in water, agricultural soil, and rice in Ngan Son district, Bac Kan province, Vietnam 7, no. 3 (2024): 329–42. http://dx.doi.org/10.47866/2615-9252/vjfc.4361.

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Coccidiostats (anticoccidial antibiotics) are veterinary drugs widely used for the prevention and treatment of coccidiosis, especially in poultry farming. The illegal use of anticoccidial antibiotics, in the wrong dosage and duration, can lead to antibiotic residues in animal products and harm the health of consumers. In this study, a highly sensitive and accurate liquid chromatography-tandem mass spectrometry method was developed for the simultaneous analysis of anticoccidial antibiotics (diclazuril, nicarbazin, robenidin and salinomycin) in food. Samples were extracted using the QuEChERS met

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Ostojić, Sanja, Darko Micić, Josipa Dukić, et al. "Thermal Characteristics and Kinetics of the Thermal Degradation of Sugar Beet Waste Leaves and Pulp in Relation to Chemical Composition." Foods 14, no. 2 (2025): 307. https://doi.org/10.3390/foods14020307.

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Thermal characteristics of dried sugar beet pulp, leaves and leaf fractions obtained after extraction: fibrous leaf pulp and fibre rich leaf fraction, were investigated by differential scanning calorimetry and thermogravimetry. The sugar beet samples showed a similar thermal behaviour associated with a similar composition. Two endotherms are found on the differential scanning calorimetry curves. First one in the temperature range 31–153 °C and the second from 150–160 °C. Thermal degradation kinetics was studied by thermogravimetric analysis. Four degradation stages were observed within the tem

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Zhu, Chang-Qi, Gilda da Cunha Santos, Keyue Ding, et al. "Role ofKRASandEGFRAs Biomarkers of Response to Erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21." Journal of Clinical Oncology 26, no. 26 (2008): 4268–75. http://dx.doi.org/10.1200/jco.2007.14.8924.

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PurposeTo evaluate the effect of KRAS and epidermal growth factor receptor (EGFR) genotype on the response to erlotinib treatment in the BR.21, placebo-controlled trial.Patients and MethodsWe analyzed 206 tumors for KRAS mutation, 204 tumors for EGFR mutation, and 159 tumors for EGFR gene copy by fluorescent in situ hybridization (FISH). We reanalyzed EGFR deletion/mutation using two highly sensitive techniques that detect abnormalities in samples with 5% to 10% tumor cellularity. KRAS mutation was analyzed by direct sequencing.ResultsThirty patients (15%) had KRAS mutations, 34 (17%) had EGFR

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Petit, K. M., A. J. Zynda, M. Anderson, C. P. Tomczyk, and T. Covassin. "A-31 Association Between Cognitive Activity and Recovery Outcomes in College Students Following Concussion." Archives of Clinical Neuropsychology 35, no. 5 (2020): 627. http://dx.doi.org/10.1093/arclin/acaa036.31.

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Abstract Objective To evaluate the relationship between self-reported cognitive activity and recovery outcomes (symptom reporting, recovery time) in college students following concussion. Method Cognitive activity was defined as self-reported minutes spent in class and studying during the first 5 days following concussion. Self-reported symptoms were reported at day 5 post-injury using the Post-Concussion Symptom Scale (PCSS). The PCSS evaluates 22 symptoms on a 7-point Likert Scale from 0 (none) to 6 (severe). Recovery time was defined as total days from injury to unrestricted medical clearan

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