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Статті в журналах з теми "159. 974: 37 (043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Wiseman, Gregory A., Leo I. Gordon, Pratik S. Multani, et al. "Ibritumomab tiuxetan radioimmunotherapy for patients with relapsed or refractory non-Hodgkin lymphoma and mild thrombocytopenia: a phase II multicenter trial." Blood 99, no. 12 (2002): 4336–42. http://dx.doi.org/10.1182/blood.v99.12.4336.

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Mildly thrombocytopenic patients with relapsed or refractory low-grade non-Hodgkin lymphoma (NHL) have an increased risk of chemotherapy-induced myelosuppression following treatment. The safety and efficacy of radioimmunotherapy with a reduced dose of90Y ibritumomab tiuxetan (0.3 mCi/kg [11 MBq/kg]; maximum 32 mCi [1.2 GBq]) was evaluated in 30 patients with mild thrombocytopenia (100-149 × 109 platelets/L) who had advanced, relapsed or refractory, low-grade, follicular, or transformed B-cell NHL. The ibritumomab tiuxetan regimen included an infusion of rituximab (250 mg/m2) and injection of 1

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2

Pedroza, Albert, Zack Fleishhacker, Colette Galet, and Lucy Wibbenmeyer. "37 Procedural Pain Management in Burn Patients (Phase II) - A Quality Improvement Project." Journal of Burn Care & Research 43, Supplement_1 (2022): S25—S26. http://dx.doi.org/10.1093/jbcr/irac012.040.

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Abstract Introduction This quality improvement project (QI) focused on reducing procedural pain. Phase I of this project demonstrated a need to improve our patients' and nurses’ satisfaction with pain control management during hydrotherapy. In this phase (Phase II), we educated the nursing staff on 1) appropriate dosing and timing of opioid administration (Oral and IV) and 2) need for more frequent midazolam administration before hydrotherapy. We also assessed the safety and potential benefits of ketamine for procedural pain control. Methods Patients undergoing wound cleaning procedures were s

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3

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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4

Hernández-Cruz, B., M. J. Miranda García, J. Barrera, et al. "AB1030 PATIENT CARE AT THE FRACTURE LIAISON SERVICE REDUCE THE GAP IN THE TREATMENT OF OSTEOPOROSIS BETWEEN MEN AND WOMEN." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1638–39. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4150.

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BackgroundOsteoporosis (OP) between men and women is different,and the way it is treated also differs. In men, the gap in clinical care, especially diagnosis and treatment, is worse.ObjectivesTo analyze the differences in the clinical characteristics of OP (demographics, comorbidities, diagnosis, and treatment) in an gold star Fracture Liaison Service (FLS).MethodsDesign: Observational, prospective, analytical study of usual clinical practice. All patients treated from an FLS from May 2018 to August 2021 were prospectively included. Of each patient, 160 clinical variables were introduced in a

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5

Abdul Rahman, Rozana, Neethu Billy Graham Mariam, Hitesh Mistry, et al. "Differential response rates in early-phase cancer clinical trials (EPCCT)." Journal of Clinical Oncology 39, no. 15_suppl (2021): 3133. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.3133.

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3133 Background: The primary objective of EPCCT (phase I and non-randomised phase II trials) is to determine the safety and tolerability of new therapeutic agents. Response rates (RR) in these trials have typically been reported at around 10-15%. Increasingly RR and survival outcomes are now investigated in EPCCT as primary or secondary objectives. Methods: Retrospective data analysis was performed on patients (pts) enrolled onto an EPCCT between January 2018 and December 2019 at The Christie NHS Foundation Trust, UK. Data on demographics, prior systemic treatment, sites of disease, performanc

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6

Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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7

Hajji, K. Tawfiki, F. Lépine, J. G. Bisaillon, and R. Beaudet. "Simultaneous removal of phenol, ortho- and para-cresol by mixed anaerobic consortia." Canadian Journal of Microbiology 45, no. 4 (1999): 318–25. http://dx.doi.org/10.1139/w99-003.

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Two different anerobic consortia, one removing phenol and ortho- (o-) cresol and the other removing para- (p-) cresol, were cultivated in serum bottles using whey as cosubstrate substitute for proteose peptone. Phenol and p-cresol removal with the phenol-removing consortium were the same with 0.0125% (w/v) whey as with 0.05% proteose peptone. For the other consortium, 8 days were required to decrease the p-cresol concentration from 35 to 2 mg/L with 0.025% whey, while 35 days were required to achieve a similar removal with 0.5% proteose peptone. The two consortia were mixed and cultivated with

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8

Dallemagne, M., E. Ghys, D. De Troy, and I. Donnay. "259 DOES THE SENSITIVITY TO OXIDATIVE STRESS DEPEND ON THE SEX OF THE EMBRYO?" Reproduction, Fertility and Development 27, no. 1 (2015): 219. http://dx.doi.org/10.1071/rdv27n1ab259.

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Male and female bovine embryos show several differences as early as the blastocyst stage. For example, differences are observed in metabolism, developmental kinetics, or gene expression that can lead to a shift in the sex ratio. Interestingly, the culture medium differentially affects male and female embryos. We previously showed that male Day 7 blastocysts present lower apoptotic rates than females (Ghys et al. 2013 Reprod. Fertil. Dev. 25, 194). The objective of the present study was to determine if such difference might be related to a differential sensitivity to oxidative stress, known to

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9

Sawattep, Jeeranut, Thad A. Howard, Noppawan P. Morales, et al. "Single Nucleotide Polymorphism (SNP) Discovery within the UGT1A Gene Complex: Allelic Frequencies and Ethnic Differences." Blood 104, no. 11 (2004): 3780. http://dx.doi.org/10.1182/blood.v104.11.3780.3780.

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Abstract The UDP-glycosyltransferase (UGT1A) gene complex plays an important role in the hepatic metabolism of many chemicals, toxins, and drugs including bilirubin and acetaminophen. In this large gene complex that spans over 200kb, there are at least 13 different coding regions that can serve as exon 1, followed by a common sequence that contains exons 2–5. These variable exon 1 sequences confer different chemical specificities for binding compounds, while exons 2–5 provide glycosyltransferase function (glucuronidation) that enhances water solubility and excretion. Mutations and polymorphism

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10

Polizzotto, Mark N., Irini Sereti, Thomas S. Uldrick, et al. "Pomalidomide Induces Expansion of Activated and Central Memory CD4+ and CD8+ T Cells in Vivo in Patients with and without HIV Infection." Blood 124, no. 21 (2014): 4128. http://dx.doi.org/10.1182/blood.v124.21.4128.4128.

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Abstract Background: Despite antiretroviral therapy (ART), people with HIV continue to exhibit immune deficits including failure to fully reconstitute CD4 T cell numbers and function, resulting in increased risks of tumors and infections and reduced response to vaccination. Pomalidomide, a derivative of thalidomide (IMID), has immunomodulatory properties that may be beneficial in this setting. We explored its impact on lymphocyte number and activation in patients with and without HIV treated within a prospective clinical trial for Kaposi sarcoma. Methods: Patients received pomalidomide 5mg ora

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11

Lakshman, Arjun, Jithma P. Abeykoon, Shaji Kumar, et al. "Daratumumab-based combination therapies (DCT) in heavily-pretreated patients (pts) with relapsed and/or refractory multiple myeloma (RRMM)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 8038. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.8038.

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8038 Background: Daratumumab-based Combination Therapies (DCT) with bortezomib (V)/ lenalidomide (R)/ pomalidomide (P) and dexamethasone (d) showed exceptional activity in RRMM in trials. Experience outside of trials since the approval of Daratumumab (D) in 2015 is limited. Methods: RRMM pts seen at Mayo Clinic, MN from 12/2015 -12/2016 were reviewed. Pts who received ≥ 1cycle of DCT were included. Time-to-event analyses were done from date of starting DCT. Common terminology criteria for adverse events v4.0 were used to grade toxicities. Results: Of 130 pts, 59% were males and median age at D

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12

Yan, Ran, Amanda Devine, Evania Marlow, et al. "Resistant Starch Intake Is Low in Australian Adults With Irritable Bowel Syndrome Who Follow a Low FODMAP Diet." Current Developments in Nutrition 6, Supplement_1 (2022): 757. http://dx.doi.org/10.1093/cdn/nzac062.026.

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Abstract Objectives This observational study aimed to assess dietary intake, including resistant starch (RS) in adults with Irritable Bowel Syndrome (IBS), who follow a habitual diet low in Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols (FODMAP) (LFD). Methods Twenty-six participants in Perth, Western Australia with IBS (23 females, aged mean ± SD 37 ± 13 years with a Body Mass Index of 23 ± 3 kg/m2) had FODMAP content assessed using the Monash University Comprehensive Nutrition Assessment Questionnaire and dietary RS from 3-d weighed food diary analysed using publish

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13

Abou Zahr, Abdallah, Jorge E. Cortes, Srdan Verstovsek, et al. "Eltrombopag for the Management of Thrombocytopenia Associated with Tyrosine Kinase Therapy in Patients with Chronic Myeloid Leukemia and Myelofibrosis." Blood 128, no. 22 (2016): 3062. http://dx.doi.org/10.1182/blood.v128.22.3062.3062.

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Abstract Background: Grade ≥ 3 thrombocytopenia occurs in 20-45% of patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKI). While most instances resolve with TKI transient interruptions and dose reductions, persistent or recurrent thrombocytopenia may adversely influence TKI efficacy. Similarly, patients with myelofibrosis (MF) treated with ruxolitinib may experience thromobocytopenia requiring dose adjustments and interruptions, also potentially affecting efficacy. Methods: We initiated a pilot study to assess the efficacy of eltrombopag for patients with C

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14

Essilini, Anaïs, Thibault Comont, Johanne Germain, et al. "Interest in Initiating Corticosteroids By Intravenous Methylprednisolone at Standard Dose in Newly Diagnosed Immune Thrombocytopenia Adults: Results of the Prospective Carmen Registry." Blood 128, no. 22 (2016): 3736. http://dx.doi.org/10.1182/blood.v128.22.3736.3736.

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Abstract Introduction . In France as in many other countries, first-line treatment of adult immune thrombocytopenia (ITP) is based on conventional dose (1 mg/kg/d) oral steroids (CDOS) during 3 weeks. Intravenous polyvalent immunoglobulin (IVIg) is added in case of severe bleeding. However, conventional dose (1 mg/kg/d) intravenous methylprednisolone (CDMP) is often used as a first-line treatment during a few days before continuation with oral prednisone. Indeed, CDMP may induce earlier response in comparison with CDOS due to the absence of intestinal absorption and of hepatic metabolism to be

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15

Bergamaschi, Paola, Cesare Perotti, Claudia Del Fante, et al. "Collection and Transplantation of Related UCB. 10 Years Experience of the Pavia CB Bank." Blood 108, no. 11 (2006): 5411. http://dx.doi.org/10.1182/blood.v108.11.5411.5411.

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Abstract Besides large-scale banking of unrelated units, CB banks (CBBs) collect and store dedicated cord blood (CB) for sibling patients. In this setting the recipient is already designated, therefore special care is applied to all critical steps of CB management, from collection to infusion, to ensure the highest quality of the graft and the successful outcome of transplant. CB collection procedures must also protect mother and infant donors. According to FACT Netcord standards, delivery practice cannot be modified in attempt to increase CB volume. In case of in utero collection, additional

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16

Ongaratto, F. L., A. Tríbulo, M. Ramos, P. Rodriguez, and G. A. Bó. "207 OOCYTE RECOVERY RATES AND IN VITRO BLASTOCYST PRODUCTION IN CATTLE TREATED WITH A SINGLE INJECTION OF FOLLTROPIN-V DILUTED IN A SLOW-RELEASE FORMULATION." Reproduction, Fertility and Development 23, no. 1 (2011): 202. http://dx.doi.org/10.1071/rdv23n1ab207.

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We have previously shown that superstimulation of beef donors with a single intramuscular (IM) injection of Folltropin-V (Bioniche Animal Health, Belleville, Ontario, Canada) diluted in a proprietary slow-release formulation (SRF; Bioniche Animal Health) results in in vivo embryo production comparable with the traditional twice-daily IM administration over 4 days (Tribulo et al. 2010 Reprod. Fertil. Dev. 22, 367). Two experiments were designed to evaluate oocyte recovery and in vitro blastocyst production of oocyte donors superstimulated with Folltropin-V, administered in twice-daily injection

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17

Palatianou, M., C. Tsentidis, M. Tzouvala, et al. "P0324 Lower Bone Mineral Density and alterations in bone biomarkers DKK-1, Sclerostin, and Periostin in individuals with Inflammatory Bowel Disease." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i785. https://doi.org/10.1093/ecco-jcc/jjae190.0498.

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Abstract Background Inflammatory Bowel Disease (IBD) affects the gastrointestinal tract but often presents with extraintestinal manifestations in many patients, including the decline in bone mass. The pathogenesis of IBD is primarily attributed to disturbances in immune responses within the gastrointestinal mucosa and potential disruptions in gut microbiomes. The inflammation of gastrointestinal tract triggers various systems, including the Wnt pathway, which is associated with bone loss. This study explores the alterations in Bone Mineral Density (BMD) and the levels of dickkopf-1(DKK-1), scl

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18

Saqlain, Monaza, Junaid Anwar, and Bilal Hameed. "A Digital Solution for monitoring the Anxiety Level of University Students." Inverge Journal of Social Sciences 2, no. 1 (2023): 1–16. https://doi.org/10.63544/ijss.v2i1.7.

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The performance of a student is greatly influenced by their psychological and mental well-being. Institutions do not consider this factor when evaluating performance of the students' performance. Students' levels of depression and anxiety are increasing for a variety of reasons, including: achieving a low GPA, getting tired of studying, and having issues with the course material. We propose a technological approach that enables educational institutions to evaluate students' mental health and levels of anxiety in order to address this issue. We developed an Android application containing four d

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19

Baraliakos, X., A. Deodhar, D. Van der Heijde, et al. "POS1103 BIMEKIZUMAB MAINTAINED IMPROVEMENTS IN EFFICACY ENDPOINTS AND HAD A CONSISTENT SAFETY PROFILE THROUGH 52 WEEKS IN PATIENTS WITH NON-RADIOGRAPHIC AND RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM TWO PARALLEL PHASE 3 STUDIES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 873.2–874. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1562.

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BackgroundBimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)-17F in addition to IL-17A, met all primary/secondary endpoints at Week (Wk) 16 in patients (pts) with active non-radiographic axial spondyloarthritis (nr-axSpA) and radiographic axSpA (r-axSpA; i.e., ankylosing spondylitis), in the parallel phase 3 BE MOBILE 1 and 2 studies, respectively.[1,2]ObjectivesTo assess efficacy and safety of BKZ in these pts up to Wk 52.MethodsBE MOBILE 1 (NCT03928704) and 2 (NCT03928743) both involved a 16-wk placebo (PBO)-controlled and 36-wk maintenance period.[1,2]P

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20

Matevosyan, Karén, Christopher Madden, Fleur M. Aung, et al. "Management of Warfarin Associated Intracranial Hemorrhage with a 3-Factor Prothrombin Complex Concentrate and Low Dose Recombinant Factor VIIa." Blood 112, no. 11 (2008): 3397. http://dx.doi.org/10.1182/blood.v112.11.3397.3397.

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Abstract Background: Intracranial hemorrhage (ICH) is a serious complication of warfarin therapy. Plasma infusion is the current standard of care in the US, even though most guidelines recommend prothrombin complex concentrate (PCC) as the preferred therapy; PCC has several advantages over plasma including no ABO blood type requirement, no lengthy thawing and infusion process, and a very small volume of virally inactivated pure vitamin K-dependent factors (VKDF) content that causes neither volume overload nor TRALI. Ideal PCC should contain adequate amounts of all VKDF (4-factor). As our group

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21

Herrero-Morant, A., J. Loricera, I. Ferraz-Amaro, et al. "AB0707 PREDICTIVE FACTORS OF RELAPSE IN GIANT CELL ARTERITIS TREATED WITH TOCILIZUMAB." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1557.2–1558. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4399.

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BackgroundTocilizumab (TCZ) is the only biologic therapy approved for giant cell arteritis (GCA). Clinical trials with TCZ in GCA was performed with intravenous (iv) TCZ in a phase 2 trial[1], and with subcutaneous (sc) TCZ in the phase 3 GiACTA[2].There is general agreement on the initial/maintenance dose, but duration of TCZ therapy is not well established. In GiACTA trial, after one year on TCZ, most patients had GCA relapse after withdrawal.ObjectivesTo assess the predictive factors of relapse in GCA in a clinical practice scenario.MethodsMulticentre observational study of 471 patients wit

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22

Rahman, Fahd, Roy N. Gay, Samir K. Ballas, et al. "Predictors of Adverse Outcomes in Hospitalized Adult Patients with Sickle Cell Disease." Blood 106, no. 11 (2005): 3197. http://dx.doi.org/10.1182/blood.v106.11.3197.3197.

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Abstract The identification of patients with sickle cell disease at risk of serious complications at the time of hospital admission can help stratify patients who will need aggressive management. We identified predictors associated with adverse outcomes such as frequent hospitalizations, acute pain crises and acute chest syndromes. To that end, we retrospectively reviewed medical records of 265 adult sickle cell disease patients, hospitalized between 1/1/98 and 2/3/05 at Mercy Catholic Medical Center, with complete clinical and laboratory data. 195/73.6% had HbSS and the rest had HbSC, HbSβ-th

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23

Deodhar, A., D. Van der Heijde, L. S. Gensler, et al. "POS0939 BIMEKIZUMAB IN PATIENTS WITH ACTIVE NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: 24-WEEK EFFICACY & SAFETY FROM BE MOBILE 1, A PHASE 3, MULTICENTRE, RANDOMISED, PLACEBO‑CONTROLLED STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 772–73. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2416.

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BackgroundBimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. BKZ has shown rapid and sustained efficacy and was well tolerated up to 156 weeks (wks) in a phase 2b study in patients (pts) with active ankylosing spondylitis.1,2ObjectivesTo assess efficacy and safety of BKZ vs placebo (PBO) in pts with active non-radiographic axial spondyloarthritis (nr-axSpA) up to Wk 24 in the ongoing pivotal phase 3 study, BE MOBILE 1.MethodsBE MOBILE 1 (NCT03928704) comprises a 16-wk double-blind, PBO-controlled period and 36-wk maintenance period. Pts were

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24

Tambaro, Francesco Paolo, Carlos Vigil, Yumin Hu, et al. "Levels of Nrf2 and Keap1 Are Associated with Poor Prognostic Features In Myelodysplastic Syndromes (MDS)." Blood 116, no. 21 (2010): 1874. http://dx.doi.org/10.1182/blood.v116.21.1874.1874.

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Abstract Abstract 1874 Background: Cellular metabolism and oxidative stress are important in the biology and pathophysiology of hematologic malignancies. Limited studies are available regarding metabolic pathways, including production of reactive oxygen species (ROS), and biology and pathogenesis of MDS. Elevated levels of ROS have been described in other leukemias, linked to increased levels of antioxidant molecules and activation of pathways that protect cells from the oxidative stress. The Nuclear erythroid 2 related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (Keap1) - Antioxidant

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Dhani, N. C., T. Roberts, M. Pintilie, et al. "Risk of Acute Leukemia Post-Autologous Stem Cell Tranplant (ASCT) for Hodgkin’s Lymphoma (HL) Depends on Choice of Salvage Chemotherapy and Use of Radiation." Blood 110, no. 11 (2007): 1674. http://dx.doi.org/10.1182/blood.v110.11.1674.1674.

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Abstract Background: Late treatment-related mortality (TRM) and second cancers (SC) have an important impact on the long-term outcome of patients (pts) with HL. The optimum salvage regimen (based on efficacy and acute and late toxicity) as part of second-line therapy with ASCT is not known. Pts undergoing ASCT are at high risk of both solid tumors and leukemia (Proc ASCO 2007 abstr #8016). We analyzed our single-institution data to determine the contribution of the components of salvage therapy to leukemia risk post-transplant. Methods: From Dec 1986 to Nov 2005, 321 pts with relapsed/refracto

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26

Wesseling, Jelle. "Abstract F1-2: Clonal evolution of DCIS to invasion." Cancer Research 83, no. 5_Supplement (2023): F1–2—F1–2. http://dx.doi.org/10.1158/1538-7445.sabcs22-f1-2.

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Abstract Clonal evolution of DCIS to invasion Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive breast cancer (IBC). If not treated, at least 3 out of 4 women with DCIS will not develop IBC1-3. This implies many women with non-progressive, low-risk DCIS are likely to carry the burden of overtreatment. To solve this DCIS dilemma, two fundamental questions need to be answered. The first question is, how the subsequent IBC is related to the initial DCIS lesion. The seco

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Stephenson, Christine F., Carol S. Berger, Lioudmila I. Richmond, Jason P. Edmiston, Eduardo S. Cantu, and Henry Y. Dong. "Cytogenetic Profile of Plasma Cell Neoplasms with 1q21 (CKS1B) Gains: A Comparative Study Between Cytoplasmic Immunoglobulin (cIg) Fluorescence In Situ Hybridization (FISH) and Conventional FISH Involving 1283 Patients,." Blood 118, no. 21 (2011): 3442. http://dx.doi.org/10.1182/blood.v118.21.3442.3442.

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Abstract Abstract 3442 Gains of 1q21 (CKS1B) in plasma cell neoplasms (PCNs) occur frequently and are generally thought to be indicative of an adverse prognosis. The International Myeloma Workshop Consensus Panel 2 (May 2011) found there is insufficient data to suggest routine use of 1q21 (CKS1B) in risk stratification of PCNs. This same Workshop confirmed that FISH testing in PCNs should be plasma cell (PC) specific. Despite this, many laboratories still perform conventional FISH (conv FISH) testing for PCNs primarily due to cost and labor constraints. This study had three objectives: 1) to e

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M., N. Abubacker, and Mehala T. "Physico-chemical analysis of textile dye effluent using microbial consortia mediated degradation process." Biolife 5, no. 1 (2022): 60–67. https://doi.org/10.5281/zenodo.7359415.

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<strong>ABSTRACT</strong> Physico-chemical analysis of textile dye effluent have shown higher concentrations of total solids, total suspended solids, total dissolved solids, biological oxygen demand, chemical oxygen demand, dissolved oxygen, total hardness, carbonate, bicarbonate alkalinities, chloride, calcium, magnesium, sodium, sulphate, zinc, chromium, copper and lead was found to be above permissible levels of WHO standards which ensure the presence of pollutant overloaded in the textile effluent. Bacterial consortia was developed with <em>Bacillus subtilis </em>(NCBT 012), <em>Clostridiu

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Patrick, Katharine, Rachel Wade, Nicholas Goulden, et al. "Improved Outcome for Children and Young People with T-Acute Lymphoblastic Leukaemia: Results of the UKALL 2003 Trial." Blood 124, no. 21 (2014): 3702. http://dx.doi.org/10.1182/blood.v124.21.3702.3702.

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Abstract T-ALL accounts for around 15% of paediatric ALL and carries a less favourable prognosis than B-ALL due to a higher relapse rate (RR) and poor response to salvage therapy. We sought to determine if the outcome for patients with T-ALL had improved on a contemporary, response based treatment protocol, UKALL 2003, which did not include pre-emptive cranial radiotherapy or high dose methotrexate. NCI standard risk patients received a 3 drug induction with dexamethasone, vincristine and pegylated asparaginase (1000 units/m2) (regimen A). NCI high risk (HR) patients also received daunorubicin

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Bolomsky, Arnold, Niklas Zojer, Martin Schreder, and Heinz Ludwig. "CXCR3 Binding Chemokines MIG, IP-10 and ITAC Are Predictors of Overall Survival in Newly Diagnosed Multiple Myeloma." Blood 124, no. 21 (2014): 2052. http://dx.doi.org/10.1182/blood.v124.21.2052.2052.

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Abstract Background. The chemokine receptor CXCR3 and its binding molecules MIG, IP-10 and ITAC have been associated with tumor progression, immune escape and angiogenesis in several human malignancies. In multiple myeloma (MM), CXCR3 binding molecules were shown to induce migration of MM cells without effecting proliferation. More recent results suggest a tumor suppressive activity of IP-10. Presently, information about the precise role of CXCR3 binding chemokines in MM is limited and evidence for their clinical significance is lacking. Therefore we aimed to evaluate the prognostic relevance

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Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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Hens, Luc, Nguyen An Thinh, Tran Hong Hanh, et al. "Sea-level rise and resilience in Vietnam and the Asia-Pacific: A synthesis." VIETNAM JOURNAL OF EARTH SCIENCES 40, no. 2 (2018): 127–53. http://dx.doi.org/10.15625/0866-7187/40/2/11107.

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Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban

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Hafeez, Muhammad Usman, Farhat Fatima, Syeda Tehmina Bukhari, et al. "A Synergistic Imperative: An Integrated Policy and Education Framework for Navigating the Climate Nexus." Inverge Journal of Social Sciences 4, no. 2 (2025): 118–24. https://doi.org/10.63544/ijss.v4i2.135.

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Climate change acts as a systemic multiplier of threats, exacerbating interconnected global crises that jeopardize food security, biodiversity, and environmental health. These challenges are compounded by socioeconomic inequalities and governance gaps, with vulnerable populations disproportionately bearing the consequences of rising temperatures, extreme weather events, and ecosystem degradation. While climate policy and environmental education have been extensively researched as separate disciplines, the critical intersection where these two fields must converge to function synergistically, b

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Freire, Joselyn, Maritza Vaca, and Manuel Almeida. "LAVADO DE FIBRA DE ALPACA (Vicugna pacos) MEDIANTE COMPUESTOS BIODEGRADABLE Y CARBONATO DE CALCIO." Revista Recursos Naturales Producción y Sostenibilidad 3, no. 1 (2024): 52–68. https://doi.org/10.61236/renpys.v3i1.626.

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El presente estudio llevado a cabo en el Laboratorio de Fibras Agroindustriales y Curtiembre de la Facultad de Ciencias Pecuarias de la Escuela Superior Politécnica de Chimborazo. Se evaluaron los efectos del lavado de la fibra de alpaca con distintas concentraciones de bicarbonato de sodio, en combinación con detergente biodegradable. Se emplearon 16 unidades experimentales, cada una con 200 g de fibra, distribuidas en cuatro tratamientos replicados cuatro veces. Se aplicó un Diseño Completamente al Azar para el análisis de resultados, utilizando estadísticas descriptivas, análisis de varianz

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Warmansyah, Jhoni, Elis Komalasari, Eliza Febriani, Gusmiati, and Amalina. "Factors Affecting Teacher Readiness for Online Learning (TROL) in Early Childhood Education: TISE and TPACK." JPUD - Jurnal Pendidikan Usia Dini 16, no. 1 (2022): 32–51. http://dx.doi.org/10.21009/jpud.161.03.

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This study aims to find empirical information about the effect of Technological Pedagogical Content Knowledge (TPACK), and Technology Integration Self Efficacy (TISE) on Teacher Readiness for Online Learning (TROL). This study uses a quantitative survey method with path analysis techniques. This study measures the readiness of kindergarten teachers in distance learning in Tanah Datar Regency, West Sumatra Province, Indonesia with a sampling technique using simple random sampling involving 105 teachers. Empirical findings reveal that; 1) there is a direct positive effect of Technology Integrati

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Mogwitz, Sabine, Christian Albus, Petra Beschoner, et al. "Mental distress of physicians in the outpatient care throughout the COVID-19 pandemic: emotional and supportive human relations matter – Cross-sectional results of the VOICE-study." BMC Health Services Research 23, no. 1 (2023). http://dx.doi.org/10.1186/s12913-023-09361-3.

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Abstract Background The aim of this cross-sectional study was to evaluate the course of self-reported mental distress and quality of life (QoL) of physicians, working in the outpatient care (POC). Outcomes were compared with a control group of physicians working in the inpatient care (PIC), throughout the Corona Virus Disease (COVID)-19 pandemic. The impact of risk and protective factors in terms of emotional and supportive human relations on mental distress and perceived QoL of POC were of primary interest. Methods Within the largest prospective, multi-center survey on mental health of health

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Rebaz M. Ali, Abdulwahid M. Salih, Hiwa O. Abdullah, et al. "Clinicopathological Features of Indeterminate Thyroid Nodules: A Single-center Cross-sectional Study." Barw Medical Journal, November 6, 2024. https://doi.org/10.58742/bmj.v2i4.137.

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Introduction Due to indeterminate cytology, Bethesda III is the most controversial category within the Bethesda System for Reporting Thyroid Cytopathology. This study examines the characteristics and malignancy rates of thyroid nodules (TNs) classified as Bethesda III. Methods Data were collected by reviewing electronic medical records, encompassing demographic details, medical history, chief complaint, laboratory tests (including thyroid function tests), preoperative imaging, cytology results, management, and histopathology diagnosis. Results The majority of the cases were female (84.7%). Pat

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Torres-Aparcana, Harold L., Agüero-Zamora Rosa, Juan C. Lizarzaburu, et al. "7095 A Comparative Analysis of the Cardiometabolic Profile of Latino Adults with 1-Hour Post-load Plasma Glucose ≥155 mg/dl, But Normal Fasting and 2-hour Glucose, Versus Those with Other Prediabetes Criteria During an Oral Glucose Tolerance Test." Journal of the Endocrine Society 8, Supplement_1 (2024). http://dx.doi.org/10.1210/jendso/bvae163.642.

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Abstract Disclosure: H.L. Torres-Aparcana: None. A. Rosa: None. J.C. Lizarzaburu: None. L. Villena: Employee; Self; Novo Nordisk. J. Rocca: None. K. Manrique: None. S. James: None. Background: 1-hour (h) post-load plasma glucose has been proposed as a prediabetes criterion because of its capacity to predict the development of type 2 diabetes. Objective: To compare, in a Latin population, the cardiometabolic profile of adults with 1-h post-load plasma glucose ≥ 155 mg/dl but normal fasting and 2-h glucose versus those with other prediabetes criteria during an oral glucose tolerance test (OGTT).

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Adjedj, Julien, Bruyne Bernard De, Vincent Floré, et al. "Significance of Intermediate Values of Fractional Flow Reserve in Patients With Coronary Artery Disease." February 1, 2016. https://doi.org/10.1161/circulationaha.115.018747.

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Background— The fractional flow reserve (FFR) value of 0.75 has been validated against ischemic testing, whereas the FFR value of 0.80 has been widely accepted to guide clinical decision making. However, revascularization when FFR is 0.76 to 0.80, within the so-called gray zone, is still debatable. Methods and Results— From February 1997 to June 2013, all patients with single-segment disease and an FFR value within the gray zone or within the 2 neighboring FFR strata (0.70–0.75 and 0.81–0.85) were included. Study end points consisted of major adverse cardiovascular events (death, myocardial in

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Chen, W., S. Liu, M. Jiang, J. Wang, and J. Dai. "B-048 Performance Evaluation of the New Anti-Streptolysin-O Assay on Mindray BS-2800M System." Clinical Chemistry 69, Supplement_1 (2023). http://dx.doi.org/10.1093/clinchem/hvad097.391.

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Abstract Background Elevated serum concentrations of Anti- Streptolysin-O(ASO) can be used to provide serologic evidence of past or present infection by β-Hemolytic Streptococci. Increasing serum concentrations of ASO antibodies are produced in response to ASO exotoxins secreted by the bacteria. Measurement of ASO antibody levels in serum can be used as an aid in the diagnosis of diseases such as glomerulonephritis, rheumatic fever, bacterial endocarditis, tonsillitis, and scarlet fever, etc. The New ASO assay has been evaluated on Mindray BS-2800M that is an automated, high throughput, and lo

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Colaneri, M., G. Montrucchio, G. Scaglione, et al. "P01. The IMPACT-VAP study: incidence and mortality of ventilator-associated pneumonia in critically ill patients: results from the PROSAFE project." JAC-Antimicrobial Resistance 7, Supplement_2 (2025). https://doi.org/10.1093/jacamr/dlaf046.001.

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Abstract Background Despite preventive measures, ventilator-associated pneumonia (VAP) persists as the most frequent healthcare-associated infection in intensive care units (ICUs),1 with high incidence and mortality rates.2,3 Here, we wanted to study the incidence of VAP in 192 Italian ICUs in the last decade. Secondly, we wanted to describe the clinical and microbiological characteristics. Finally, we wanted to assess the variables associated with their intra-ICU mortality. Methods In this multicentric observational study, data from 192 Italian ICUs were retrieved from the PROSAFE project, a

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HUTTASCH, MAXIMILIAN, SABINE KAHL, TIM MORI, et al. "1564-P: Hepatic Lipid Content Associates with Fasting and Prandial Glucagon Secretion in Recent-Onset Type 2 Diabetes." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-1564-p.

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Hyperglycemia in type 2 diabetes (T2D) associates with higher glucagon secretion, which may be further promoted in the presence of metabolic dysfunction-associated steatotic liver disease (MASLD). Thus, we compared fasting and prandial glucagonemia in people with and without recent-onset T2D and MASLD. Participants of the German Diabetes Study (GDS), with T2D (n=50; known duration &lt;1 year) or with normal glucose tolerance (NGT; n=50), underwent mixed meal tolerance tests (MMT; 365 kcal) and hyperinsulinemic-normoglycemic clamps. Early prandial glucose and hormone secretion were quantifi

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sprotocols. "Dual-Color ELISPOT Assay for the Simultaneous Detection of IL-2 and/or IFN-γ Secreting T Cells". 30 грудня 2014. https://doi.org/10.5281/zenodo.13617.

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Authors: Salix Boulet, Michel L. Ndongala and Nicole F. Bernard1 Corresponding author ([nicole.bernard@mcgill.ca](nicole.bernard@mcgill.ca)). ### INTRODUCTION The enzyme-linked immunospot (ELISPOT) assay measures the secretion intensity of effector molecules released by immune cells in response to ex vivo antigenic stimulation, as well as the frequency of these responding cells. This assay is highly sensitive, quantitative, easy to use, and amenable to high-throughput screening. For these reasons, the ELISPOT assay is considered by many as a gold standard for monitoring cellular immune respons

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sprotocols. "Dual-Color ELISPOT Assay for the Simultaneous Detection of IL-2 and/or IFN-γ Secreting T Cells". 30 грудня 2014. https://doi.org/10.5281/zenodo.13618.

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Authors: Salix Boulet, Michel L. Ndongala and Nicole F. Bernard1 Corresponding author ([nicole.bernard@mcgill.ca](nicole.bernard@mcgill.ca)). ### INTRODUCTION The enzyme-linked immunospot (ELISPOT) assay measures the secretion intensity of effector molecules released by immune cells in response to ex vivo antigenic stimulation, as well as the frequency of these responding cells. This assay is highly sensitive, quantitative, easy to use, and amenable to high-throughput screening. For these reasons, the ELISPOT assay is considered by many as a gold standard for monitoring cellular immune respons

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Thi Thuy Quynh, Nguyen, Pham Le Ngoc Han, Vo Khanh Tam, Phung Thi Kim Hue, and Tsai -Lien Huang. "Microarray Data Analysis of as-induced Rice Roots by using Easygo and Mapman Softwares." VNU Journal of Science: Natural Sciences and Technology 35, no. 3 (2019). http://dx.doi.org/10.25073/2588-1140/vnunst.4860.

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Rice is one of the most important crops in Asian countries such as China, Vietnam... Many recent reports indicate that the arsenic content in rice exceeds the threshold and affects human health. Studying of molecular mechanisms and finding the arsenic resistance genes in rice which is extremely important and urgent. In this study, we analyzed the transcriptional changes of arsenic-treated rice root cells during 24 hours by microarray technique. Results showed that a large number of the differentially expressed genes (720 genes). EasyGO and Mapman softwares are powerful tools in analyzing micro

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sprotocols. "Assay for quantitative determination of CYP1A1 enzyme activity using 7-Ethoxyresorufin as standard substrate (EROD assay)." December 31, 2014. https://doi.org/10.5281/zenodo.13665.

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Authors: Afshin Mohammadi-Bardbori ### Abstract The activity of the enzyme 7-ethoxy-resorufin-O-deethylase (EROD) has been extensively employed in biomonitoring studies of persistent organic pollutants (POPs) for more than a decade. Although the procedure is simple, convenient, sensitive and accurate. The cytochrome P450 monooxygenase 1A (CYP1A) is induced by several planar toxic compounds and endogenous chemicals, and the induction of this protein is often measured in terms of EROD activity. This protocol describes how to use EROD activity in the prediction of toxicity of chemicals in several

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Minh, Phan Hong, Vu Khanh Linh, Nguyen Thanh Hai, and Bui Thanh Tung. "A Comprehensive Review of Vaccines against Covid-19." VNU Journal of Science: Medical and Pharmaceutical Sciences 37, no. 3 (2021). http://dx.doi.org/10.25073/2588-1132/vnumps.4365.

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The globe is engulfed by one of the most extensive public health crises as COVID-19 has become a leading cause of death worldwide. COVID-19 was first detected in Wuhan, China, in December 2019, causing the severe acute respiratory syndrome. This review discusses issues related to Covid-19 vaccines, such as vaccine development targets, vaccine types, efficacy, limitations and development prospects. Keywords: Covid-19, SARS-CoV-2, vaccine, spike protein. References [1] C. Wang, P. W. Horby, F. G. Hayden, G. F. Gao, A Novel Coronavirus Outbreak of Global Health Concern, The Lanc

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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