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Готові списки джерел за темами / -(3 Chloro-1-benzothien-2 yl)-4-phenyl-4H-1 / Статті в журналах

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Статті в журналах з теми "-(3 Chloro-1-benzothien-2 yl)-4-phenyl-4H-1"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Amit, Chattree* and Neelottma Singh. "In-Silico Designing of 5-(3 Chloro-1-Benzothien-2yl)-4-Phenyl-4H-1,2,4 Triazole-3-Thiol derivatives and their Potential application on Fusarium Solani." Journal of Pharma Research 1, no. 2 (2012): 7–10. https://doi.org/10.5281/zenodo.1098653.

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<strong><em>ABSTRACT</em></strong> <em>In silico methods can help in identifying drug targets via bioinformatics tools. The use of computers and computational methods permeates all aspects of drug discovery and forms the core of structure-based drug design. High-performance computing, data management software and internet are facilitating the access of huge amount of data generated and transforming the massive complex biological data into workable knowledge in modern day drug discovery process. In the present work insilico designing of 5-(3 Chloro-1-benzothien-2yl)-4-phenyl-4H-1,2,4 triazole-3

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2

M. Daoud, Khalid, Amal N. Ali, and Amina A. Ahmed. "Synthesis of 2-(3-chloro-4-nitro-1-benzothien-2-yl)-1,3,4-oxadiazole-1,3,4-thiadiazole and 5-(3-chloro-4-nitro-1-benzothien-2-yl)-4H-1,2,4-triazole-3-thiol." JOURNAL OF EDUCATION AND SCIENCE 23, no. 4 (2010): 19–26. http://dx.doi.org/10.33899/edusj.2010.59245.

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3

V, Mujalda, S. Tiwari, V. Sharma, P. Saxena, and M. Shrivastava. "Synthesis of 3-chloro-4- (2-hydroxy-5-(substituted phenyl (diazyl)-N-[(4-oxo-2-phenylquinazoline 3(4H)-yl)]-2-oxoazetidine-1-carbothiamide Analogs as Potential Antimicrobial Agents." International Journal of Drug Design and Discovery 3, no. 2 (2025): 798–802. https://doi.org/10.37285/ijddd.3.2.8.

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Some new series of 3-chloro-4-(2-hydroxy-5-(substituted phenyl (diazyl)-N-[(4-oxo -2-phenylquinazoline 3(4H)-yl)]-2-oxoazetidine-1-carbothiamide have been synthesized by the reaction of 1-[2-hydroxyl–5–(substituted phenyl)diazyl benzylidene-3-(4-oxo-2-phenylquinazolin-3(4H)-yl) thiourea with chloroacetyl chloride and triethyl amine in 1,4 dioxane. The structure of synthesized compounds is confirmed by IR, NMR & Mass spectral studies. The antimicrobial activities of the synthesized compounds were evaluated by screening on different human pathogens using the disc diffusion assay.

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4

Antre, R. V., R. J. Oswal, D. B. Thorat, and R. B. Shete. "Edaravone Part 2: Antibacterial Activity of Novel Substituted Azetidinone Derivatives of Edaravone." International Journal of Drug Design and Discovery 3, no. 2 (2025): 749–52. https://doi.org/10.37285/ijddd.3.2.1.

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This paper describes development of new chemical entities of Edaravone for their antibacterial activity. The chemical name of Edaravone is 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one. Various N-(substituted benzylidenyl)-[2-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)acetohydrazide] (4a-4e) and 2-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)-acetamide- (3-chloro-4-substituted phenylazetidin-2-one) (DTa-DTe) screened for their antibacterial activity against Escherichia coli and Bacillus subtilis.

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5

N. Mousa, Mazin. "EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL." Basrah Journal of Veterinary Research 11, no. 1 (2012): 122–27. http://dx.doi.org/10.33762/bvetr.2012.54766.

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6

SG, Jawarkar, and Game MD. "Synthesis, Characterization and Antimicrobial Evaluation of New Substituted Thiazolidinones Bearing Triazole Moiety." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 02 (2024): 796–802. http://dx.doi.org/10.25258/ijpqa.15.2.39.

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Series of thiazolidinone derivatives containing triazole moiety have been synthesized by condensing various substituted aldehydes to form Schiff bases which further reacts with thioglycolic acid undergoes ring condensation to form 3-(3-mercapto-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-4-yl)-2-substituted phenylthiazolidin-4-one followed by reaction with ethyl chloroacetate to form ethyl 2-((4-(2-subtituted phenyl-4-oxothiazolidin-3-yl)-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate. The synthesized compounds were characterized by elemental analysis, fourier-

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7

Orrego Hernandez, Jessica, Jaime Portilla, Justo Cobo, and Christopher Glidewell. "Two different products from the reaction of 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde with cyclohexylamine when the aryl substituent is phenyl or pyridin-2-yl: hydrogen-bonded sheetsversusdimers." Acta Crystallographica Section C Structural Chemistry 71, no. 5 (2015): 363–68. http://dx.doi.org/10.1107/s2053229615006403.

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Cyclohexylamine reacts with 5-chloro-3-methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carbaldehyde to give 5-cyclohexylamino-3-methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carbaldehyde, C16H20N4O, (I), formed by nucleophilic substitution, but with 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde the product is (Z)-4-[(cyclohexylamino)methylidene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, C17H21N3O, (II), formed by condensation followed by hydrolysis. Compound (II) crystallizes withZ′ = 2, and in one of the two independent molecular types the cyclohexylamine unit is disordered over two sets of atomic sites

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8

Chunduri, Venkata Rao. "Synthesis and Antibacterial Activity of Novel Benzimidazole Linked 1,3,4-Oxadiazole Derivatives." Medicinal Chemistry 9, no. 2 (2019): 6. https://doi.org/10.4172/2161-0444.1000529.

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With an intention to develop potent antimicrobial agents from the source of benzimidazole- 1,3,4-oxadiazole combined heterocyclic derivatives, novel 6-Chloro-2-(2-(5-(substituted phenyl)-1,3,4-oxadiazol-2-yl)ethyl)- 1H-benzo[d]imidazole derivatives were synthesized using condensation reaction of 3-(6-chloro-1H-benzo[d] imidazol-2-yl)propane hydrazide and benzoic acids as key step in presence of POCl3 . All newly synthesized target compounds (4a-4n) were characterized by 1 H NMR, Mass and IR spectral studies and were screened for their antibacterial activity with two bacterial pathogens (Gram p

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9

Shaik, Afzal, Palleapati Kishor, and Venkata Kancharlapalli. "Synthesis of Novel and Potential Antimicrobial, Antioxidant and Anticancer Chalcones and Dihydropyrazoles Bearing Isoxazole Scaffold." Proceedings 41, no. 1 (2020): 16. http://dx.doi.org/10.3390/ecsoc-23-06476.

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A series of isoxazole based (E)-1-(isoxazole-5-yl)-3-(substituted phenyl)-prop-2-en-1-ones (chalcones, 3a-3o) and 3-(isoxazol-5-yl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide (dihydropyrazoles, 4a-4o) were synthesized, characterized and evaluated for their antimicrobial, antioxidant and anticancer properties. Chalcones exhibited excellent antibacterial and antioxidant activities whereas the dihydropyrazoles shown superior antifungal and anticancer activities. The compound 3l containing 3,4,5-trimethoxy phenyl ring showed the potent antibacterial activity (MIC = 1 µg/mL) as we

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10

Fuerst, E. Patrick, Charles J. Arntzen, Klaus Pfister, and Donald Penner. "Herbicide Cross-Resistance in Triazine-Resistant Biotypes of Four Species." Weed Science 34, no. 3 (1986): 344–53. http://dx.doi.org/10.1017/s0043174500066960.

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The cross-resistance of triazine-resistant biotypes of smooth pigweed (Amaranthus hybridusL. # AMACH), common lambsquarters (Chenopodium albumL. # CHEAL), common groundsel (Senecio vulgarisL. # SENVU), and the crop canola (Brassica napusL. var. Atratower) to a selection of herbicides was evaluated at both the whole plant and chloroplast level. The triazine-resistant biotypes of all four species showed a similar pattern of cross-resistance, suggesting that a similar mutation had occurred in each species. The four triazine-resistant biotypes were resistant to injury from atrazine [6-chloro-N-eth

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11

Dhokale, Sandhya, Snehal Thakar, and Deepali Bansode. "Design and synthesis of novel 1-substituted -3-(4-oxo-2-phenylquinazolin-3(4H)-yl) urea and thiourea analogues targeting on TACE, as potent anticancer agents." GSC Biological and Pharmaceutical Sciences 12, no. 2 (2020): 194–205. https://doi.org/10.5281/zenodo.4268200.

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1-substituted phenyl quinazolinones analogues were designed by performing molecular modelling studies against tumour necrosis factor alpha converting enzyme (TACE PDB Id: 2A8H) and <em>in-silico </em>Lipinski properties for drug likeness.  From QSAR studies, it could be concluded that the urea and thiourea groups play a crucial role in enhancing cytotoxic effects of compounds. Substitution of halogens like trifluoromethyl, chloro and allylic functional group may enhance the cytotoxic effect of urea and thiourea analogues. Substitution of phenyl and benzoyl ring were not found ef

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12

Verma, Tarawanti, Manish Sinha, and Nitin Bansal. "Synthesis of Novel 1,2-Dihydro-1,2,4-Triazin-6(5H)-one Derivatives as Anticancer Agents." Current Bioactive Compounds 16, no. 7 (2020): 1116–31. http://dx.doi.org/10.2174/1573407215666191022123310.

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Introduction: Cancer is still an untreatable disease and the second leading cause of death globally. The heterocyclic compounds have always played a major role in the anticancer drug discovery program. 1,2,4-Triazine-6-ones is a heterocyclic privileged structure with diversified activities. In the presented study, 21 novel 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6 (5H)-one derivatives (13(a-k), 18(a-j) and 21(a1-a4, b)) have been synthesized and tested for their anticancer activity. Methods: The 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6(5H)-one derivatives (13(a-k), 1

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13

Abouzied, Amr S., Jehan Y. Al-Humaidi, Abdulrahman S. Bazaid, et al. "Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety." Molecules 27, no. 19 (2022): 6368. http://dx.doi.org/10.3390/molecules27196368.

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Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity. The starting 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-3-phenylthiourea (2) was prepared and reacted with various hydrazonoyl halides 3a–h, α-haloketones 5a–d, 3-chloropentane-2,4-dione 7a and ethyl 2-chloro-3-oxobutanoate 7b, which afforded the 3-aryl-5-substituted 1,3,4-thiadiazoles 4a–h, 3-phenyl-4-arylthiazoles 6a–d and the 4-methyl-3- phenyl

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14

Dash, Biswajit, Suvakanta Dash, and Damiki Laloo. "DESIGN AND SYNTHESIS OF 4-SUBSTITUTED QUINAZOLINE DERIVATIVES FOR THEIR ANTICONVULSANT AND CNS DEPRESSANT ACTIVITIES." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 1 (2016): 165. http://dx.doi.org/10.22159/ijpps.2017v9i1.15492.

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<p><strong>Objective: </strong>The present work is designed to synthesise some isomeric new series of Quinazoline-4-one/4-thione derivatives, based on the pharmacophoric model of central nervous system (CNS) activity by structural modifications retaining the essential structural features for the activity and evaluated for their anticonvulsant and CNS depressant properties.</p><p><strong>Methods: </strong>A series of 7-chloro-3-[substituted (amino/phenylamino)]-2-phenyl quinazolin-4 (3H)-one/thione derivatives and 1-(7-chloro-4-oxo/-2-phenylquinazoline-

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15

Jin, Feng, Dan Gao, Cunlong Zhang, et al. "Exploration of 1-(3-chloro-4-(4-oxo-4H-chromen-2-yl)phenyl)-3-phenylurea derivatives as selective dual inhibitors of Raf1 and JNK1 kinases for anti-tumor treatment." Bioorganic & Medicinal Chemistry 21, no. 3 (2013): 824–31. http://dx.doi.org/10.1016/j.bmc.2012.04.006.

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16

Somagond, Shilpa Mallappa, Manjunath Ningappa Wari, Saba Kauser Jaweed Shaikh, et al. "Detailed analytical studies of 1,2,4-triazole derivatized quinoline." European Journal of Chemistry 10, no. 4 (2019): 281–94. http://dx.doi.org/10.5155/eurjchem.10.4.281-294.1844.

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The present study describes, the X-ray single crystal analysis of 4-((2-chloro-6-methoxyquinolin-3-yl)methyl)-2-phenyl-2H-1,2,4-triazol-3(4H)-one (TMQ). The crystal data for C19H15ClN4O2: monoclinic, space group P21/n (no. 14), a = 7.3314(15) Å, b = 12.459(3) Å, c = 18.948(4) Å, β = 98.322(9)°, V = 1712.5(6) Å3, Z = 4, T = 296.15 K, μ(MoKα) = 0.245 mm-1, Dcalc = 1.423 g/cm3, 5082 reflections measured (3.926° ≤ 2Θ ≤ 38.556°), 1428 unique (Rint = 0.0545, Rsigma = 0.0574) which were used in all calculations. The final R1 was 0.0423 (I >2σ(I)) and wR2 was 0.1145 (all data). The Density function

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17

Russell, Rachel, Rachel Doyle, Jamie Turner, et al. "In vitro and in vivo pharmacological characterisation of the potent and selective vasopressin V1A receptor antagonist 4-[4-(4-Chloro-phenyl)-5-[1,2,3]triazol-2-ylmethyl-4H-[1,2,4]triazol-3-yl]-piperidin-1-yl-(3,5-difluoro-phenyl) methanone (PF-00738245)." European Journal of Pharmacology 670, no. 2-3 (2011): 347–55. http://dx.doi.org/10.1016/j.ejphar.2011.09.034.

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18

Shyshkina, Mariia O., Dmitry A. Lega, Volodymyr D. Goryachiy, Ludmila M. Shemchuk, Dmitriy V. Levashov, and Leonid A. Shemchuk. "2-Amino-4-(4-chloro-1-ethyl-2,2-dioxo-1H-benzo[c][1,2]thiazin-3-yl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile: single-crystal X-ray diffraction study and Hirshfeld surface analysis." Acta Crystallographica Section E Crystallographic Communications 77, no. 3 (2021): 294–97. http://dx.doi.org/10.1107/s2056989021002085.

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In the title compound, C22H22ClN3O4S, which has potential non-steroidal anti-inflammatory activity, the benzothiazine and cyclohexenone rings both adopt a distorted sofa conformation while the 4H-pyrane ring adopts a very flattened sofa conformation. The two bicyclic fragments are skewed to each other, with the dihedral angle between their least-squares planes being 72.8 (1)°. In the crystal, the molecules form a hydrogen-bonded chain parallel to the a axis due to N—H...O and N—H...Cl hydrogen bonds. Neighbouring chains are linked by C—H...N, C—H...O and π–π stacking interactions. Hirshfeld su

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19

Swanson, Devin M., Brad M. Savall, Kevin J. Coe, et al. "Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor." Journal of Medicinal Chemistry 59, no. 18 (2016): 8535–48. http://dx.doi.org/10.1021/acs.jmedchem.6b00989.

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20

CHAUBAN, Vishal, Sbivkanya FULORIA, Neeraj K. FULORIA, Syed R. HASHIM, and Sokindra KUMAR. "SYNTHESIS, CHARACTERIZATION AND COMPARATIVE SCREENING OF SOME NEWER 2-PHENYL INDOLE AND 5-CHLORO-2-PHENYL INDOLE DERIVATIVES." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 20, no. 20 (2012): 69–76. http://dx.doi.org/10.48141/sbjchem.v20.n20.2012.71_revista_2012a.pdf.

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Biologically active phenyl indole and chloro phenyl indole derivatives were efficiently synthesized. The reaction of 2-phenyl-1H-indole A and 5-chloro-2-phenyl-1H-indole B, with chloroacetylchloride yielded 2-chloro-1-(2-phenyl-1H-indol-1-yl)ethanone 1 and 2-chloro-1-(5-chloro-2-phenyl-1H-indol-1-yl)ethanone 4 respectively. Compound 1 and 4 on Friedal Crafts cyclization in presence of aluminium chloride and nitrobenzene yielded indolo[2,1 -alfa]isoquinolin-6(5H)-one 2 and 10-chloroindolo [2,1-alfa]isoquinolin-6(5H)-one 5 respectively, which upon hydrolysis afforded 2-(2-(1H-indol-2-yl)phenyl)a

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21

Takaki, Reina, and Bradley O. Ashburn. "(E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(3-chloro-4-fluorophenyl)prop-2-en-1-one." Molbank 2022, no. 2 (2022): M1375. http://dx.doi.org/10.3390/m1375.

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Imidazole-containing chalcones have been shown to be effective against Aspergillus fumigatus, the pathogenic agent for pulmonary aspergillosis. Claisen-Schmidt condensation of 4-(1H-imidazol-1-yl)benzaldehyde with 3′-chloro-4′-fluoroacetophenone using aqueous sodium hydroxide in methanol yielded the novel compound (E)-3-[4-(1H-imidazol-1-yl)phenyl]-1-(3-chloro-4-fluorophenyl)prop-2-en-1-one in good purity after purification by silica gel column chromatography. This novel compound is suitable for testing the antifungal properties of the combined pharmacophores against Aspergillus and other path

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22

Emmie de, Abreu, S. K. Chandavarkar, B. S. Biradar, Bobde S. S., S. P. Naik, and S. N. Mamledesai. "DESIGN, SYNTHESIS AND PSYCHOPHARMACOLOGICAL ACTIVITY OF QUINOLIN-2-ONE DERIVATIVES." INDIAN DRUGS 56, no. 08 (2019): 21–26. http://dx.doi.org/10.53879/id.56.08.11925.

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Starting material 4-hydroxy-1-phenyl/methyl-quinolin-2-(1H)-one was treated with phosphorous oxychloride and then subjected to Mannich reaction to yield title 4-chloro-1-phenyl/methyl-3-[3- (substituted) propanoyl] quinolin-2(1H)-one derivatives compounds IIa (1-7)/ IIb (1-7). Molecular docking studies of the compounds were carried out using Molegro Virtual Docker. All the synthesized compounds were characterized by IR, 1H-NMR and Mass Spectral data and were tested for their antidepressant activity. Amongst the synthesized compounds, compound 4-chloro-1-phenyl-3-[3-(morpholinopropanoyl] quinol

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23

Mistry, Bhavnaben D., Kishor R. Desai, and Nigam J. Desai. "SYNTHESIS, IN VITRO ANTIMICROBIAL ACTIVITY OF SCHIFF’S BASE, AZETIDINONES AND THIAZOLIDINONES." International Journal of Current Pharmaceutical Research 9, no. 1 (2016): 126. http://dx.doi.org/10.22159/ijcpr.2017v9i1.16634.

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Objective: The objective of the present study is to synthesize 3-Chloro-4-[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyrazol-4-yl]-1-(substituted) azetidin-2-one [4a-n] and 2-[3-(2,4-Dichloro-5-fluoro phenyl)-1H-pyraol-4-yl]-3-(substituted phenyl)-1,3-thiazolidin-4-one [5a-n]. The structure of all synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral studies. Methods: The titled compounds 3-Chloro-4-[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyrazol-4-yl]-1-(substituted) azetidin-2-one [4a-n] and 2-[3-(2,4-Dichloro-5-fluoro phenyl)-1H-pyraol-4-yl]-3-(substituted phenyl)-1,3-thi

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24

Barlin, GB, and C. Jiravinyu. "Potential Antimalarials. XII. 4-Chloro-3-(substituted amino)methyl-5-[7-bromo (and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]biphenyl-2-ols and 4-Chloro-3-(substituted amino)methyl-5-(7-trifluoromethyl-quinazolin-4-ylamino)biphenyl-2-ols." Australian Journal of Chemistry 43, no. 8 (1990): 1367. http://dx.doi.org/10.1071/ch9901367.

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The mono- Mannich bases 3-(t- butylamino )methyl-4?-chloro-, 3-(4- benzylpiperidin-1-yl)methyl-4′-chloro-, 3-(4-benzylpiperazin-1- yl )methyl-4′-chloro-, 4′-chloro-3-diethylaminomethyl-, 4′-chloro-3-(pyrrolidin-1-yl)methyl-, 4′-chloro-3-(piperidin-1-yl)methyl- and 4′-chloro-3-(3- and 4- methylpiperidin-1-yl)methyl-5-[7-bromo (and 7- trifluoromethyl )-1,5-naphthyridin-4-ylamino]- biphenyl-2-ol, and the corresponding substituted 5-(7-trifluoromethylquinazolin-4-ylamino)bi- phenyl-2-ols, have been prepared by condensation of the 5-amino-3-(N- substituted aminomethyl )-4′-chlorobiphenyl-2-ols and

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25

P. Jeyanthi, P. Jeyanthi, and P. Pazhanisamy P. Pazhanisamy. "Synthesis and Characterization of 3-Chloro-1-(7- Nitrobenzothiazole-2-Yl) - 4 - Substituted Phenyl Azetidin- 2 - One." Indian Journal of Applied Research 4, no. 5 (2011): 82–84. http://dx.doi.org/10.15373/2249555x/may2014/26.

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26

Parmar, M. B., J. H. Pandya, and M. K. Vara. "Synthesis, Characterization of Various Substituted (E)-2-(2-butyl-5-chloro-4-((phenylimino)methyl)-1H-imidazol-1-yl)-N-(4-(3-oxomorpholino) phenyl)acetamide." Journal of Scientific Research 15, no. 2 (2023): 509–18. http://dx.doi.org/10.3329/jsr.v15i2.61736.

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A highly efficient, convergent approach to the synthesis of various substituted (E)-2-(2-butyl-5-chloro-4-((phenylimino)methyl)-1H-imidazol-1-yl)-N-(4-(3-oxomorpholino)phenyl) acetamide analogues is described. Directed vilsmeyer formylation of methyl pentanimidate with glycine provides the key intermediate 2-butyl-5-chloro-1H-imidazole-4- carbaldehyde (INT-01). BCFI (INT-01) is a major active metabolite and the most significant intermediate of Losartan. Therefore, BCFI moiety has scope for good application in medicine. Morpholin-3-one derivative reacts with chloroacetyl chloride in presence of

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27

Denislamova, E. S., V. A. Lyadov, D. E. Makrushin, V. G. Ryabov, M. V. Dmitriev, and A. N. Maslivets. "Synthesis of 1-antipyryl-1<i>H</i>-pyrrol-2-ones by interaction <i>N</i>-antipyryl substituted enamines with oxalyl chloride." Журнал органической химии 59, no. 4 (2023): 535–40. http://dx.doi.org/10.31857/s0514749223040122.

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Methyl 4-aryl-2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-ylamino)-4-oxo-2-butenoates react with oxalyl chloride to form methyl 3-aroyl-2-chloro-1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-yl)-4-hydroxy-5-oxo-2, 5-dihydro-1 H -pyrrole-2-carboxylates, which are hydrolyzed to methyl 3-aroyl1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-yl)-2,4-dihydroxy-5-oxo-2,5-dihydro-1 H -pyrrole2-carboxylates, the structure of which was confirmed by X-ray diffraction analysis.

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28

Sandip, Sen, S. Easwari T., and De Biplab. "Antimicrobial and anti-nociceptive profile of some 4-(3-methyl-1-phenyl-1Hpyrazol-4-yl)-1-phenylazetidin-2-o." Journal of Indian Chemical Society Vol. 91, Nov 2014 (2014): 2089–99. https://doi.org/10.5281/zenodo.5741383.

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IIMT College of Medical Sciences, O. Pocket, Ganga Nagar, Meerut-250 001, Uttar Pradesh, India Regional Institute of Pharmaceutical Science and Technology, Abhoynagar, Agartala-799 006, Tripura, India <em>E-mail </em>: biplab_32@yahoo.co.in <em>Manuscript received online 04 March 2014, revised 28 April 2014, accepted 16 June 2014</em> A new series of 4-(3-methyl-1-phenyl-1<em>H</em>-pyrazol-4-yl)-1-phenylazetidin-2-ones (7a-j) were prepared by intermolecular cyclization of Schiff bases (6a-j) and mono chloro acetyl chloride in the presence of base catalyst triethyl amine. The biological evalua

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29

Journal, Baghdad Science. "Synthesis of some Schiff's bases derivatives from aminoazo compounds." Baghdad Science Journal 4, no. 3 (2007): 416–19. http://dx.doi.org/10.21123/bsj.4.3.416-419.

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Reaction of,2- [( 4- amio phenyl ) diazenyl] 1,3,4- thiadiazole -5- thiol (S1) with p- chlorobenzeldehyde,3,4 – dimethoxy benzaldehyde and pyrrol-2- carbonxaldehyde gave -5- [{4-(4-chlorobenzylidene amino) phenyl} diezenyl]-1,3,4- thiadiazole-2- thiol (S2),5-[{ 4-[(3,4- dimethoxybenzyldene )amino phenyl ] diazenyl)-1,3,4- thiadiazole-2-thiol,(S3) and -5- [4-(1,H – pyrrol -2- yl- methylene)amino phenyl] diazenyl)-1,3,4- thiadiazole-2- thiol (S4) respectively as schiff's bases compounds. On the same route-2-[(4-amino-1- naphthyl ) diazenyl] -1,3,4- thiadiazole -5- thiol (S5) reacts with –p- chlo

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30

Chaurasia, Sarita, Gaddi Divija, Dyapa Divya, M. Divya, Habeebunnisa ., and Miryanam Harshitha. "Synthesis and characterization of some novel 1,3,4-oxadiazole for anti-inflammatory activity." International Journal of Multidisciplinary Research and Growth Evaluation 4, no. 1 (2023): 365–68. http://dx.doi.org/10.54660/.ijmrge.2023.4.1.365-368.

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A series of five-membered heterocyclic rings were synthesized by the reaction between 2[(4-chlorophenyl) acetyl] benzoic acid and and SOCl2 produced acid chloride and the acid chloride on reaction with substituted aromatic acid to form (3a- 3d) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified by column chromatography. All synthesized derivatives were determined by the carrageenan-induced rat-paw-oedema model for anti-inflammatory

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31

Rahman, Mujeeb Ur, Ankita Rathore, Anees A. Siddiqui, Gazala Parveen, and M. Shahar Yar. "Synthesis and Antihypertensive Screening of New Derivatives of Quinazolines Linked with Isoxazole." BioMed Research International 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/739056.

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Анотація:

A series of 7-substituted-3-(4-(3-(4-substitutedphenyl)-4,5-dihydroisoxazol-5-yl)phenyl)-2-substituted quinazolin-4(3H)-one(1–30)have been synthesized by the cyclization of (E)-3-(4-(3-substitutedphenyl)acrylolyl)phenyl)-2-(substitutedphenyl)-7-substituted quinazolin-4-(3H)-one with hydroxylamine hydrochloride. The synthesized compounds were examined for theirin vivoantihypertensive activity using albino rats. All the titled compounds exhibited good to moderate antihypertensive activity. Compounds 7-Chloro-3-(4-(3-(4-chlorophenyl)-4,5- dihydroisoxazol-5-yl)phenyl)-2-p-tolylquinazolin-4(3H)-one

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32

Youssef, Ahmed Said Ahmed. "Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile and 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile with substituted benzylidenemalononitriles, α,β-acetylenic esters and ketones". Journal of Chemical Research 2009, № 4 (2009): 214–17. http://dx.doi.org/10.3184/030823409x435874.

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Анотація:

Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile (1a) with substituted benzylidenemalononitriles gave 4-amino-2-(1-cyano-2-arylvinyl)benzothieno[2,3- d]pyrimidine derivatives (3) as ( E,Z)-mixtures and in one case (2c) as separated ( Z)- and ( E)-isomers. Similar treatment of 6-amino-1,4-dihydro-3-methyl-1,4-diphenyl-pyrano[2,3- c]pyrazole-5-carbonitrile (4) yielded similarly-formed pyrazolopyranopyrimidine derivatives (5a, b) as ( Z)-and ( E)-stereoisomers. Attempted acetylation of the aminobenzothienopyrimidines resulted in degradation of the pyrimidine ring and the fo

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33

SG, Jawarkar, and Game MD. "Synthesis, Characterization and Antimicrobial Activity of Novel 2-Azetidinones Compounds." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 242–48. http://dx.doi.org/10.25258/ijpqa.15.1.38.

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A series of 2-azetidinone derivatives were synthesized by the formation of triazole, followed by synthesis of Schiff’s bases by condensation of various substituted aldehydes. The Schiff’s bases further reacted to chloroacetyl chloride in the presence of triethyl amine, and undergoes cyclocondensation to give substituted 3-chloro-1-(3-mercapto-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-4-yl)-4-phenylazetidin-2-one which on further reaction with ethyl chloroacetate, gives substituted ethyl 2-((4-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-3-((5-methoxy-1H-indol-1-yl)methyl)-4,5-dihydro-1H-1

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34

Fuloria, Neeraj Kumar, Vijender Singh, M. Shaharyar, and Mohd Ali. "SYNTHESIS AND ANTIMICROBIAL STUDIES OF NOVEL IMINES AND OXADIAZOLES." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 16, no. 16 (2008): 11–22. http://dx.doi.org/10.48141/sbjchem.v17.n17.2008.14_2008.pdf.

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N-benzylidene-2-(4-chloro-3-methylphenoxy)acetohydrazides (3a-e), obtained by arylation of 2-(4-chloro-3-methyl phenoxy)acetohydrazide (2), was cyclized with acetic anhydride to yield 1-(5-(( 4-chloro-3-methylphenoxy)methyl)-2-phenyl-l ,3,4-oxadiazol- 3(2H)-yl)ethanones (4a-e). All the newly synthesized compounds were analytically and spectrally characterized and evaluated for anti-bacterial and anti-fungal activities.

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35

Rajput, Chatrasal Singh, and Shiwani Singhal. "Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs." Journal of Pharmaceutics 2013 (January 17, 2013): 1–7. http://dx.doi.org/10.1155/2013/907525.

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A series of 3-[2′-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5–10), 3-[2′-(3″-chloro-2″-oxo-4″-substitutedphenylazetidin-1″-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11–16), and 3-[2′-(2″-substitutedphenyl-4″-oxo-1″,3″-thiazolidin-3″-yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones (17–22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H1 NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic a

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36

J., A. Patel, D. Mistry B., and R. Desai K. "Synthesis of some novel 4-thiazolidinone compounds and their application as potential antimicrobial agent." Journal of Indian Chemical Society Vol. 83, Oct 2006 (2006): 1041–43. https://doi.org/10.5281/zenodo.5831373.

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Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India <em>Manuscript received 14 July 2005, revised 4 January 2006, accepted 28 June 2006</em> 3-Chloro-1-[5' -hydroxy-2' -(phenyldiazenyl) phenyll-4-[2" -hydroxy-5" -(1<em>"' </em>,3<em>'"</em> -benzothiazol-2<em>"'</em> -yl-diazenyl)phenyl)-2-azetidinone (4a-p),3-[5'-hydroxy-2'-(phenyldiazenyl)phenyl]-2-[2" -hydrox)·-5" -(1"' ,3'" -benzothiazol-2"' -yl-diazenyl) phenyl)- 4-thiazolidinone (Sa-p) and 3-[5' -hydroxy-2&#3

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37

Narayana, Badiadka, Vinutha V. Salian, Balladka K. Sarojini, and Jerry P. Jasinski. "(2E)-1-(4-Chlorophenyl)-3-[4-(propan-2-yl)phenyl]prop-2-en-1-one." Acta Crystallographica Section E Structure Reports Online 70, no. 8 (2014): o855. http://dx.doi.org/10.1107/s1600536814015281.

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In the title compound, C18H17ClO, the dihedral angle between the benzene rings is 53.5 (1)°. The mean plane of the prop-2-en-1-one group is twisted by 24.5 (8) and 33.5 (3)° from the chloro- and propanyl-substituted rings, respectively.

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38

Patel, Darshana D., and Vikram N. Panchal. "Studies on Metal Complexes of Pyrazole Bearing Ligand with Their Antimicrobial Screening." Oriental Journal Of Chemistry 40, no. 5 (2024): 1394–98. http://dx.doi.org/10.13005/ojc/400522.

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In present research article, we reported the synthesise of novel hetertocyclic ligand namely,5-((3-((1H-benzimidazol-1-yl)methyl)-5-phenyl-1H-pyrazol-1-yl) methyl)-8-hydroxy quinoline (BIPPHQ) from 5-chloro methyl-8-hydroxy quinoline and 1-((5-phenyl-1H-pyrazol-3-yl) methyl)-1H-benzimidazole (BIPP). The BIPP was synthsised by the reaction between hydrazine hydrate with 1-(1H-benzimidazol-1-yl)-4-phenylbut-3-en-2-one (BIPB), which was synthesisd from 1-(1H-benzimidazol-1-yl)propan-2-one (BIP) and benzaldehyde. The transition metal complxes of 5-((3-((1H-benzimidazol-1-yl)methyl)-5-phenyl-1H-pyr

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39

Rakesh, Paliwal, Chandra Sekhar K., Taneja Amit, and K. Mishra S. "Synthesis of substituted 3-chloro-1-(3-(trifluoromethyl)-S-methoxy-4H-1,2,4- triazol-4-yl)-4-phenylazetidin-2-ones." Journal of Indian Chemical Society Vol. 87, May 2010 (2010): 589–93. https://doi.org/10.5281/zenodo.5787989.

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Chemistry Department, Faculty of Science, Narain (P.G.) College, Shikohabad-205 135, Uttar Pradesh, India Manuscript received 15 May "2009, revised 26 August 2009, accepted 28 October 2009 An efficient and extremely fast procedure to synthesize novel biologically active substituted trlnuoro-2-azetldones heterocycles was discussed. Reaction of trifluoroacetic hydrazide 2 with hydrazine hydrate and then cyclization with tetramethoxy methane yields <em>N</em>-(3-(trifluoromethyl)-5-methozy-4<em>H</em>-1,2,4-triazol-4-yl)amine 3. Condensation of the N-(3· (trifluoromethyl)-5-methozy-4<

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40

Idrees, M., Y. G. Bodkhe, N. J. Siddiqui, and S. S. Kola. "Synthesis, Characterization and in vitro Antimicrobial Screening of Some Novel Series of 2-Azetidinone Derivatives Integrated with Quinoline, Pyrazole and Benzofuran Moieties." Asian Journal of Chemistry 32, no. 4 (2020): 896–900. http://dx.doi.org/10.14233/ajchem.2020.22490.

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A series of 5-(benzofuran-2-yl)-N-(3-chloro-4-(2-(p-tolyloxy) substituted quinolin-3-yl)-2-oxoazetidin-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (4a-f) were synthesized with excellent yields by cyclocondensation reaction of 5-(benzofuran-2-yl)-N′-(2-(p-tolyloxy) substituted quinolin-3-yl)methylene)-1-phenyl-1H-pyrazole-3-carbohydrazide (3a-f) with chloroacetyl chloride in presence of triethylamine in DMF. One pot condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (1) with 2-(p-tolyloxy) substituted quinoline-3-carbaldehyde (2a-f) in ethanol solvent in presence

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41

Journal, Baghdad Science. "Synthesis of Some Heterocyclic Compounds derived from 2-mercapto pyrimidine." Baghdad Science Journal 7, no. 2 (2010): 1014–22. http://dx.doi.org/10.21123/bsj.7.2.1014-1022.

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In this work 2-hydrazino pyrimidine (1) was prepared from 2-mercapto pyrimidine with hydrazine hydrate. Treatment of (1) with active methylene compounds gave 2-(3,5-dimethyl -1 H – Pyrazole-1-yl) pyrimidine , whereas the reaction of (1) with carboxylic anhydride namely maleic anhydride or 1,2,3,6-tetra hydro phthalic anhydride yielded 1-Pyrimidine-2-yl-1,2-dihydro pyridazine-3,6-dione (3) and 2 – Pyrimidin -2-yl -2,3,4 a ,5,8 a – hexahydro phthalazine 1,4 – dione (4) . Reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-Phenyl-1,3-thiazolidine-2,4-dione-2( pyrimidine

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42

Askar, Firyal w., Huda A. Hassan, and Nahida A. Jinzeel. "Synthesis of Some Heterocyclic Compounds derived from 2-mercapto pyrimidine." Baghdad Science Journal 7, no. 2 (2010): 1014–22. http://dx.doi.org/10.21123/bsj.2010.7.2.1014-1022.

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In this work 2-hydrazino pyrimidine (1) was prepared from 2-mercapto pyrimidine with hydrazine hydrate. Treatment of (1) with active methylene compounds gave 2-(3,5-dimethyl -1 H – Pyrazole-1-yl) pyrimidine , whereas the reaction of (1) with carboxylic anhydride namely maleic anhydride or 1,2,3,6-tetra hydro phthalic anhydride yielded 1-Pyrimidine-2-yl-1,2-dihydro pyridazine-3,6-dione (3) and 2 – Pyrimidin -2-yl -2,3,4 a ,5,8 a – hexahydro phthalazine 1,4 – dione (4) . Reaction of (1) with phenyl isothiocyanate and ethyl chloro acetate afforded 3-Phenyl-1,3-thiazolidine-2,4-dione-2( pyrimidine

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43

Pawar, P. Y., P. M. Gaikwad, and P. H. Balani. "Microwave Assisted Synthesis of N-Substituted-7-hydroxy-4-methyl-2-oxoquinolines as Anticonvulsant Agents." E-Journal of Chemistry 8, no. 2 (2011): 945–51. http://dx.doi.org/10.1155/2011/121476.

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The reaction of resorcinol with ethylacetoacetate yielded the 7-hydroxy-4-methyl coumarin (1), which on treatment with benzidine gives 1-(4ʹ-amino-biphenyl-4-yl)-7-hydroxy-4-methyl-1H-quinolin-2-one (2). 1-{4ʹ-[(Substituted benzylidene)-amino]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinolin-2-one (3a-j) were obtained by reacting 1-(4ʹ-amino-biphenyl-4-yl)-7-hydroxy-4-methyl-1H-quinolin-2-one (2) with different substituted aromatic aldehydes in presence of glacial acetic acid by microwave irradiation. The compound 1-{4ɴ-[(substituted benzylidene)-amino]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinol

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44

D.K. Gautam and I. Singh. "A NEW SERIES OF 1,3,4-THIADIAZOLE SUBSTITUTED AZETIDINONE AND THIAZOLIDINONE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY." RASAYAN Journal of Chemistry 17, no. 01 (2024): 176–82. http://dx.doi.org/10.31788/rjc.2024.1718308.

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Анотація:

The new series of 2-({[5-(3-chloro-2-oxo-4-substituted-phenylazetidin-1-yl)-1,3,4-thiadiazol-2- yl]methyl}amino)benzoic acid (13-20) and 2-({[5-(4-oxo-2- substituted-phenyl-1,3-thiazolidin-3-yl)- 1,3,4- thiadiazol-2-yl]methyl}amino)benzoic acid (21-28) have been synthesized from 2-[({5-[(benzylideneamino]- 1,3,4- thiadiazol-2-yl }methyl)amino]-benzoic acid (5-12). All these synthesized compounds were tested for their antimicrobial activity and established by spectroscopic data, and elemental analyses.

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45

Al-Smaisim, Rafah Fadhil. "Synthesis, Characterization and Biological Activity of Some New 4-Substituted-phenyl-3-chloro-1-{5-[(3, 5-dimethyl-1H-pyrazol-1- yl) methyl]-1, 3, 4-thiadiazol-2-yl} azetidin-2-one." Al Mustansiriyah Journal of Pharmaceutical Sciences 12, no. 2 (2012): 123–32. http://dx.doi.org/10.32947/ajps.v12i2.258.

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Анотація:

A new series of 3,5-dimethyl-1H-pyrazole derivatives (1-15) incorporated into fused to different nitrogen and sulphur containing heterocyclic were prepared from 3,5-dimethyl-1H-pyrazole when treated with ethylchloroacetate in the present of potassium carbonate to offer Ethyl (3, 5-dimethyl-1H-pyrazol-1-yl) acetate (1).Compound (1) converted to 2-[(3,5-dimethyl -1H-pyrazol -1-yl) acetyl] hydrazinecarbothioamide (2) by reaction with thiosemicarbazide in methanol.Cyclocondensation (2) was reacted with mineral acid H2SO4 to produce 5-[(3, 5- dimethyl-1H-pyrazol-1-yl) methyl]-1, 3, 4-thiadiazol-2-a

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46

Kaushik, Darpan, and Namita Maan. "N-[1-(1H-Benzimidazol-2-yl)-2-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)vinyl]benzamide." Molbank 2011, no. 3 (2011): M731. http://dx.doi.org/10.3390/m731.

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47

Y., D. KULKARNI, RASHMI SHARMA (Miss), L. SHARMA V, and R. DUA P. "2-Substituted-5-chloro/nitrobenzophenones as Possible Anticonvulsants." Journal of Indian Chemical Society Vol. 64, Jan 1987 (1987): 46–48. https://doi.org/10.5281/zenodo.6196157.

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Анотація:

Department of Chemistry, Lucknow University, Lucknow.-226 007 Pharmacology Division, Central Drug Research Institute, Lucknow-226 001 <em>Manuscript received 8 July 1985, revised 22 May 1986, accepted 26 November 1986</em> Twenty one new 2-(<em>N</em><sup>1</sup>-substituted-phenylthiourea-<em>N<sup>2</sup></em> -y1)/(substituted-phenyl thiocarham ato)/[2-(substituted-phen)limino)thiazolid-4-one-3 yl]/[ (3-merca p to-4-su bstitutedphenyl-1, 2, 4(1)-triazol-5-yl)methylaminolmethyleneoxy]-5-chloro / nitrobenzophenones were synthesised and screened for their acute toxicit

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48

Zadrazilova, Iveta, Sarka Pospisilova, Karel Pauk, et al. "In VitroBactericidal Activity of 4- and 5-Chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/349534.

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Анотація:

A series of nine substituted 2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides was assessed as prospective bactericidal agents against three clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) andS. aureusATCC 29213 as the reference and quality control strain. The minimum bactericidal concentration was determined by subculturing aliquots from MIC determination onto substance-free agar plates. The bactericidal kinetics of compounds 5-chloro-2-hydroxy-N-[(2S)-3-methyl-1-oxo-1-{[4-(trifluoromethyl)phenyl]amino}butan-2-yl]benzamide (1f),N-{(2S)-1-[(4-bromophenyl)amino]-3-me

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49

Shailesh, H. Shah, and S. Patel Pankaj. "Synthesis and antimicrobial activity of azetidin-2-one containing pyrazoline derivatives." Journal of Indian Chemical Society Vol. 90, Jun 2013 (2013): 863–66. https://doi.org/10.5281/zenodo.5773732.

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Анотація:

Department of Chemistry, Patel J.B.R. Arts, Patel A.M.R. Commerce & Patel J.D.K.D. Science College, Borsad-388 540, Gujarat, India <em>E-mail </em>: shailchem@yahoo.com Department of Chemistry, Sheth L.H. Science College, Mansa, Gujarat, India <em>Manuscript received online 25 July 2012, revised 26 July 2012, accepted 31 July 2012</em> Pyrazolines are well-known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. A new series of 3-chloro-1-{ 4-[5-(substituted phenyl)-4,5-dihydropyrazol-3-yl]phenyl}-4-(4-choloroph

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50

M'hamedi, Ahmed, and Andrei S. Batsanov. "Phosphorescent mono- and diiridium(III) complexes cyclometalated by fluorenyl- or phenyl-pyridino ligands with bulky substituents, as prospective OLED dopants." Acta Crystallographica Section E Crystallographic Communications 76, no. 3 (2020): 392–99. http://dx.doi.org/10.1107/s2056989020001784.

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Анотація:

The crystal structures of tris[9,9-dihexyl-2-(5-methoxypyridin-2-yl-κN)-9H-fluoren-3-yl-κC 3]iridium pentane monosolvate, [Ir(C31H38NO)3]·C5H12, (I), di-μ2-chlorido-bis{bis[2-(5-fluoropyridin-2-yl)-9,9-dihexyl-9H-fluoren-3-yl]iridium} pentane 0.3-solvate, [Ir2(C30H35FN)4Cl2]·0.3C5H12, (II), di-μ2-cyanato-bis{bis[9,9-dihexyl-2-(5-methoxypyridin-2-yl)-9H-fluoren-1-yl]iridium} pentane monosolvate, [Ir2(C31H38NO)4(NCO)2(NCO)2]·C5H12, (III), and {μ-N,N′-bis[3,5-bis(trifluoromethyl)phenyl]oxamidato}bis(bis{2-[4-(2,4,6-trimethylphenyl)pyridin-2-yl]phenyl-κ2 C 1,N′}iridium)–chlorobenzene–pentane (1/2.

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