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Дисертації з теми "3 Expression"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Hettle, S. J. H. "Expression of TN1/3 transposase." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375435.

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2

Heathfield, Sarah Kathleen. "Molecular mechanism underlying MMP-3 expression." Thesis, University of Bristol, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442184.

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3

Ong, V. H. "Expression and regulation of monocyte chemoattractant protein-3 (MCP-3) in fibrosis." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/16301/.

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Systemic sclerosis is a multisystem connective tissue disease characterised by skin thickening and widespread, but variable, visceral fibrosis. The aetiopathogenesis is likely to involve immunological activation and microvascular dysfunction leading to excessive accumulation of extracellular matrix (ECM) with increased production of collagen type I in lesional tissues. This implies a dysregulated repair process probably as a consequence of aberrant crosstalk between fibroblasts and inflammatory cells. It has been proposed that a hierarchical cascade of soluble mediators in which initial induct

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4

Sethmann, Svenja. "Die Expression und Regulation des Wachstumsfaktors GDF-3." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/90/index.html.

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5

Bakopanos, Evangelos. "Regulation of the 3-adrenergic receptor gene expression." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38148.

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The beta3-adrenergic receptor (beta3-AR) represents a very attractive target for the development of anti-obesity drugs. Selective agonists have been developed based on the rodent beta3-AR and successfully used to treat obesity and Type 2 diabetes in these animals. In humans, however, these particular compounds appear to be less effective and not as specific for the beta3-AR as they are in rodents. An additional problem is the low level of expression of these receptors in human adipose, which may ultimately limit the clinical use of stronger more specific agonists. The objective of this researc

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6

Park, Seongmi. "Metallothionein isoform 3 expression in human bladder urothelium." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=3281.

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7

Radhakrishnan, Vijayababu, Charles Putnam, Wenqing Qi, and Jesse Martinez. "P53 suppresses expression of the 14-3-3gamma oncogene." BioMed Central, 2011. http://hdl.handle.net/10150/610345.

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BACKGROUND:14-3-3 proteins are a family of highly conserved proteins that are involved in a wide range of cellular processes. Recent evidence indicates that some of these proteins have oncogenic activity and that they may promote tumorigenesis. We previously showed that one of the 14-3-3 family members, 14-3-3gamma, is over expressed in human lung cancers and that it can induce transformation of rodent cells in vitro.METHODS:qRTPCR and Western blot analysis were performed to examine 14-3-3gamma expression in non-small cell lung cancers (NSCLC). Gene copy number was analyzed by qPCR. P53 mutati

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8

Young, Gavin Mitchel. "Comparative Analysis of 14-3-3 Isoform Expression and Epigenetic Alterations in Colorectal Cancer." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297797.

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Анотація:

The 14-3-3 family is a group of intracellular proteins found in all eukaryotic organisms. Humans have 7 isoforms that serve as scaffolds to promote interactions of regulatory phospho-proteins involved in many vital cellular processes. Previous studies have shown that disturbances in native 14-3-3 levels can contribute significantly to the development of various cancers. Our study aims to establish the normal and cancerous expression levels of all 7 isoforms in human colon adenocarcinomas and correlate 14-3-3 expression changes with epigenetic silencing. 14-3-3 mRNA expression levels were estab

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9

Quan, Wei. "3-D facial expression representation using statistical shape models." Thesis, University of Central Lancashire, 2009. http://clok.uclan.ac.uk/21147/.

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Facial expressions are visible signs of person's affective state, cognitive activity and personality. Automatic recognition of facial expressions is an important component for a wide spectrum of applications including human-computer interfaces, video conferencing, augmented reality and human activity monitoring to mention a few. Facial expression representation is an essential part in the automatic recognition of facial expressions. It is concerned with finding distinguishable features that can be utilised for representing different facial expressions without constraints of age, ethnicity or g

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10

Weston, Jonathan Henry. "Expression of the 3'-terminus of potato virus S." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282350.

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11

Ahmad, Athar. "Regulation and expression of stromelysin-3 in breast cancer." Thesis, King's College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401822.

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12

McNicholas, Paul Martin. "Expression of penicillin-binding protein 3 in Escherichia coli." Thesis, University of Bristol, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330079.

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13

Ryan, Gregory Robert. "Regulation of expression of the human interleukin 3 gene /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phr9885.pdf.

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14

Korpelainen, Eija. "Interleukin -3 receptor expression and function in now-hemopoietic cells /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09PH/09phk84.pdf.

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15

Moore, Kathryn Blackford. "Studies of 3-hydroxy-3-methylglutaryl coenzyme A reductase expression during Zea mays seed development." Diss., The University of Arizona, 1995. http://hdl.handle.net/10150/187096.

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Анотація:

The first committed step in isoprenoid biosynthesis is the conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, which is catalyzed by the enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR). To begin to understand the role of isoprenoid synthesis in maize, the expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase was examined. This study shows that the specific activity of the rate-limiting enzyme, HMGR, is regulated during Zea mays development. High levels of activity were correlated with stages of rapid, mitotic divisions. During seed development, HMGR specifi

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16

Teixeira, Veronica Rodrigues. "Mecanismos associados à perda de expressão do gene de galectina-3 em um modelo de progressão de melanoma murino." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5155/tde-20062007-145547/.

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Galectina-3 é uma lectina animal que apresenta afinidade por b- galactosídeos e que tem sido associada à progressão tumoral e metástase. A expressão de galectina-3 encontra-se alterada durante a progressão tumoral de diferentes neoplasias. Em tumores como carcinoma de tiróide e bexiga a expressão de galectina-3 encontra-se aumentada, enquanto que em tumores como carcinoma de mama e ovário a expressão desta lectina encontra-se diminuída. Neste trabalho nós utilizamos um modelo de progressão tumoral de melanoma murino para investigar os mecanismos envolvidos na perda de expressão de galectina-3.

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17

Murphy, Lise. "Regulation of human parainfluenza virus type 3 fusion protein expression." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26723.

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Анотація:

Human parainfluenza virus type 3 (HPIV3) is an enveloped, negative-strand, non-segmented RNA virus. HPIV3 is a human respiratory pathogen that primarily causes diseases such as croup, bronchiolitis and pneumonia in children. The virus has two glycoproteins that allow it to interact with host cells, the receptor binding protein hemagglutinin-neuraminidase (HN) and the fusion protein (F), which enables the virus to enter the cell by fusion of the viral envelope to the target cell plasma membrane. This research was initiated with the goal of determining mechanisms by which HPIV3 regulates the exp

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18

Roy, Stéphane. "Regulation of 1,25 dihydroxyvitamin D¦3-24-hydroxylase gene expression." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0006/NQ30373.pdf.

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19

Winter, Jennifer Leslie. "Oxygen regulation of TGFß¦3 expression in the human placenta." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58869.pdf.

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20

Bertocchini, Federica. "Expression and functional analysis of murine ryanodine receptor type 3." Thesis, Open University, 1998. http://oro.open.ac.uk/57732/.

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Анотація:

Ryanodine receptors (RyRs) are intracellular homotetrameric Ca2+-release channels constituting a family of three different isoforms, named RyRl, RyR2 and RyR3. RyRl and RyR2 are highly expressed in skeletal and cardiac muscles respectively, where they localize in the terminal cisternae of the sarcoplasmic reticulum (SR). Although RyRl and RyR2 have been found to be expressed in several other tissues at much lower level than in striated muscles, their major functional role is related to Ca2+-release from the SR following electrical depolarization of the plasma membrane, a process referred to as

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21

Liddell, Susan. "Expression of the yolk protein 3 gene of Drosophila melanogaster." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/11060.

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22

Sougrat, Rachid. "Expression et fonction de l'aquaporine-3 dans la peau humaine." Paris 7, 2003. http://www.theses.fr/2003PA077250.

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23

Gil, Grathwohl Karina. "Gene structure and expression patternof mouse Toll-like receptor 3." [S.l. : s.n.], 2002.

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24

Johnson, Jeremiah Gene. "Regulation of type 3 fimbrial gene expression in Klebsiella pneumoniae." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/1151.

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Анотація:

Klebsiella pneumoniae is an opportunistic, Gram-negative pathogen that is responsible for a variety of infections, including those of the respiratory and urinary tracts, following insertion of medical devices. It is believed that epithelial surfaces are mechanically disrupted through insertion of these devices thereby exposing the underlying extracellular matrix components. This disruption, as well as the in situ accumulation of matrix components on the indwelling device, has been proposed to provide a unique colonization niche for K. pneumoniae as the type 3 fimbriae of this organism have bee

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25

Park, Hee-Sung. "Molecular cloning, characterization, and expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from tomato." Diss., Virginia Tech, 1990. http://hdl.handle.net/10919/37402.

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26

Brantley, Emily Claire. "Loss of PIAS3 expression in glioblastoma multiforme tumors implications for STAT-3 activation and gene expression /." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2008d/brantley.pdf.

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27

Moura, Lívia Gonzaga. "Expressão de Galectinas-1 e 3 em Neoplasias Mieloproliferativas." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-25022013-094107/.

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Doenças Mieloproliferativas Crônicas são desordens hematológicas malignas caracterizadas pela alteração na célula-tronco hematopoética e independência ou hipersensibilidade dos progenitores hematopoéticos a citocinas. Em 2008 a OMS renomeou esse grupo como Neoplasias Mieloproliferativas (NMPs), no qual estão inclusas as entidades nosológicas Policitemia Vera (PV), Trombocitemia Essencial (TE) e Mielofibrose Primária (MFP), doenças alvo desse estudo. Apesar dos avanços no diagnóstico das NMPs e nos mecanismos envolvidos com a fisiopatologia dessas doenças, sua patogênese permanece desconhecida.

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28

Dubus, Vincent. "Expression of WT and mutant 3 neuronal nicotinic subunit constructs in 3 knock-out mouse sympathetic neurons." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33752.

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Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate excitatory synaptic signaling in vertebrate autonomic neurons. Sympathetic neurons express five of the 12 known neuronal nAChRs genes: alpha3, alpha5, alpha7, alpha2 and alpha4 and therefore several potential receptor subtypes could exist. The purpose of my study is to investigate the function of alpha3. Specifically, I test the hypothesis that alpha3 is essential for the receptor ACh sensitivity. For that purpose, I use sympathetic neurons from alpha3 knock-out mice together with gene transfer techn

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29

Chemutai, Patricia. "Gene Expression in Long Term Myoblast /Myocete Cultures: m RNA expression (Acetylcholine Receptor and Galectin-3 gene)." Youngstown State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1620382476783648.

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30

Groh, Sabine. "Die Bonusregelungen des 26 Abs. 2 S. 3 des Rundfunkstaatsvertrages /." Frankfurt am Main [u.a.] : Lang, 2005. http://www.gbv.de/dms/sbb-berlin/497944030.pdf.

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31

Murray, James. "PI 3-kinase : a key effector in C-FMS signalling." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264478.

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32

Beckmann, Roland. "Expression of the red cell anion exchanger in mammalian cells." Thesis, University of Bristol, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313008.

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33

Westlund, Alexander. "Increased expression of therapeutic proteins by identification of 3'-UTRs from high expressing genes in CHO cells." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-157593.

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Анотація:

Therapeutic proteins, a.k.a. biopharmaceuticals, are most commonly produced in expression systems derived from Chinese Hamstery Ovary (CHO) cells, thanks to great capacity of post-translational modifications like secretation, folding and glycosylation. The engineering of cells for regulation of protein expression has many options including knock-in and knock-out of genes, epigenetic studies or improvement of the expression casette of the protein of interest by e.g. promotor variants or modifications of the 5’ and 3’ untranslated region (UTR). The 3’-UTR is therefore a good optimization candida

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34

Chandler, Aglaia. "The role of RpoT;3 in chloroplast development and gene expression." Thesis, [College Station, Tex. : Texas A&M University, 2005. http://hdl.handle.net/1969.1/ETD-TAMU-1701.

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35

Benaduce, Ana Paula. "UV-Induced Melanoma Mouse Model Dependent on Endothelin 3 Over-Expression." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1613.

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Анотація:

Melanoma is one of the most aggressive types of cancer. It originates from the transformation of melanocytes present in the epidermal/dermal junction of the human skin. It is commonly accepted that melanomagenesis is influenced by the interaction of environmental factors, genetic factors, as well as tumor-host interactions. DNA photoproducts induced by UV radiation are, in normal cells, repaired by the nucleotide excision repair (NER) pathway. The prominent role of NER in cancer resistance is well exemplified by patients with Xeroderma Pigmentosum (XP). This disease results from mutations in t

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36

Jana, Lisa [Verfasser]. "Expression der Histondeacetylasen 1, 2 und 3 im Mammakarzinom / Lisa Jana." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1042940770/34.

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37

Read, Emma Mary. "Expression and transcriptional regulation of GATA-3 MRNA in Xenopus laevis." Thesis, King's College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265951.

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38

Ronaldson, Elaine. "The regulation of yolk protein 3 gene expression in Drosophila melanogaster." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/14316.

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In <I>Drosophila,</I> the three <I>yolk protein</I> (<I>yp</I>) genes are transcribed in a sex-, tissue- and developmentally specific manner, providing an ideal system in which to investigate the factors involved in their regulation. This project involved an analysis of the <I>yolk protein</I> <I>3</I> (<I>yp3</I>) gene and its flanking sequences in order to locate <I>cis</I>-acting DNA sequences necessary for the highly specific pattern of expression which, in the longer term, could be used to isolate the proteins interacting with them. Using P-element mediated germ-line transformation, it wa

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39

Isobe, Naoki. "Caspase-3 Expression in Human Gastric Carcinoma and Its Clinical Significancec." Kyoto University, 2004. http://hdl.handle.net/2433/147499.

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40

Fält, Susann. "Analysis of global gene expression in complex biological systems using microarray technology /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-612-3/.

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41

Zhang, Shengtao. "Klonierung, Expression und initiale Charakterisierung vom humanen TIM3." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972570357.

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42

Fraga, Ana Maria. "Estudo de função de HIPK2 durante o desenvolvimento embrionário." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-07032008-114953/.

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Анотація:

HIPK2 (homeodomain interacting protein kinase 2) é uma proteína quinase nuclear, originalmente identificada por interagir com homeoproteínas. Sua atividade quinase contribui para a regulação de diversas vias, ativando o programa de morte celular em resposta a estímulos externos ou promovendo diferenciação celular por atuar como co-fator de homeoproteínas. A extensa similaridade estrutural com as outras proteínas da mesma família, HIPK1 e HIPK3, sugere que as três HIPKs possuem funções redundantes. Este trabalho pretendeu contribuir para a elucidação das funções de HIPK2 avaliando a expressão

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43

Schäfers, Christina. "Identifizierung von cis- und transregulatorischen Elementen der 3[alpha]-Hydroxysteroiddehydrogenase [3-alpha-Hydroxysteroiddehydrogenase], Carbonylreduktase-Expression in Comamonas testosteroni." [S.l.] : [s.n.], 2005. http://archiv.ub.uni-marburg.de/diss/z2005/0230/.

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44

Ji, Wan. "Expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase in maize as influenced by light and bleaching herbicides." Diss., Virginia Tech, 1991. http://hdl.handle.net/10919/39911.

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Анотація:

The activity of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, EC 1.1.1.34) is highly expressed in 4-day-old etiolated seedlings of normal ('DeKalb XL72AA'), dwarf (<u>d₅</u>), and albino (<u>lw₃</u>) maize (<u>Zea mays</u> L.). HMGR activity of maize seedlings appeared to be exclusively associated with the microsomal rather than the plastidic fraction of maize cells. Maize tissues with high meristematic activity such as germinating seeds, leaf bases, root tips, and the site of origin of lateral roots contained high levels of HMGR activity. The activity of HMGR extracted fro

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45

Wertz, Mary Helene. "Aberrant microRNA Expression in Spinal Muscular Atrophy Motor Neurons." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17464519.

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Анотація:

Spinal Muscular Atrophy (SMA) is a devastating autosomal-recessive pediatric neurodegenerative disease characterized by loss of spinal motor neurons. It is caused by mutation in the survival of motor neuron 1, SMN1, gene and leads to loss of function of the full-length SMN protein. SMN has a number of functions related to RNA processing in neurons, including RNA trafficking in neurites, and RNA splicing and snRNP biogenesis in the nucleus. While previous work has focused on the alternative splicing and expression of traditional mRNAs, our lab has focused on the contribution of another RNA spec

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46

Maniatis, Silas dana. "Classical Conditioning Alters Short Noncoding RNA Expression in Drosophila." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467392.

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MicroRNAs (miRNAs) and other classes of short non-coding RNAs regulate essential processes in the development and function of the nervous system. Regulation of miRNAs by neural activity has also been reported. Recently, instances of piwi interacting RNA (piRNA) and endogenous short interfering RNA (esiRNA) mediated modulation of neural physiology have been reported. To better understand the role of miRNAs and other classes of short non-coding RNAs in long term memory (LTM) formation, we have conducted high throughput sequencing on 15-35nt RNAs isolated from heads of Drosophila that have been s

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47

Rohlfing, Amy Elizabeth. "Coordinate control of virulence gene expression in Francisella tularensis." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467492.

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Francisella tularensis is a Gram-negative, intracellular pathogen and the causative agent of tularemia. Due to its low infectious dose, ability to cause potentially fatal disease, and ability to be easily aerosolized, several countries have developed F. tularensis as a potential bioweapon. Three proteins, MglA, SspA, and PigR, and the small molecule guanosine tetraphosphate (ppGpp), are transcription factors critical for the virulence of this organism. These regulators function coordinately to positively regulate the expression of genes present on the Francisella pathogenicity island, as well

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48

Cox, Kathryn Elizabeth. "Matrix metalloproteinase-3 in uterus and endometriosis." free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3012963.

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Almeida, Neto Adauto 1977. "Abordagem quantitativa da expressão do gene WFDC1 e sua isoforma delta 3 = Quantitative approach of the expression of WFDC1 gene and its isoform delta 3." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317579.

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Orientadores: Hernandes Faustino de Carvalho, Paulo Roberto Eleutério de Souza<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-25T14:18:25Z (GMT). No. of bitstreams: 1 AlmeidaNeto_Adauto_D.pdf: 4167026 bytes, checksum: ca3afd135b583810d6996e33016f9e69 (MD5) Previous issue date: 2014<br>Resumo: A próstata é alvo de afecções severas que comprometem a função urinária, a qualidade de vida e que consistem em risco de vida aos indivíduos do sexo masculino, particularmente com o avançar da idade. Interações dinâmicas entre o epit

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Baloglu, Onur. "Analysis Of 3&#039." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615672/index.pdf.

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Cancer is the collective term used to describe a diverse group of diseases that share certain hallmarks, which in turn enables the affected cells to sustain an uncontrolled cell growth. Despite the increasing efforts and advances in cancer therapies, cancers are still responsible for approximately 10% of all the deaths worldwide. Furthermore, the increase in the average human lifespan will further contribute to the cancer incidences. This brings the necessity to focus our efforts on early detection and effective diagnosis methods. With the advances in high-throughput genomics technologies, gen

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