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Статті в журналах з теми "3202 Clinical sciences"
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Timofeeva, N. Yu, N. V. Bubnova, G. Yu Struchko, I. S. Stomenskaya, and O. Yu Kostrova. "Problems of metastasis (literature review)." MD-Onco 1, no. 1 (December 7, 2021): 93–99. http://dx.doi.org/10.17650/2782-3202-2021-1-1-93-99.
Повний текст джерелаАнотація:
Despite significant successes in the development of medical sciences, the study of oncopathology issues still occupies a leading place due to the identification of a large number of advanced cases of the disease. Firstly, this may be due to the rapid growth of a malignant tumor, for example, against the background of immunodeficiency. Secondly, with late treatment of patients, when they already have distant metastases. The success of treatment of any oncological process primarily depends on the timing of the diagnosis: the earlier the tumor is diagnosed, the greater the chance of a positive outcome and an increase in the life expectancy of the cancer patient. The most formidable complication of oncopathology and the main cause of death from it is metastasis, which often reduces to zero all the effects of therapy. Metastasis remains a mystery today. So, despite the large number of various theories, the question of the spread of the tumor throughout the body has not yet been resolved. There is no definite answer to the question: do metastases metastasize? The mechanisms of the influence of hormones on the processes of metastasis have not been fully studied. Difficulties in diagnosis are associated with the lack of clinical manifestations before the appearance of metastases, the inability to track and compare changes in tissues and organs in vivo, the non-specificity of the results of available research methods, and the lack of control of the spread of metastases throughout the body. Experimental studies on laboratory animals can provide answers to these and many other questions. In a review of the literature, a study of the main issues of metastasis is conducted.
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Abraham, Reem Rachel, Faith Alele, Ullas Kamath, Annamma Kurien, Kiranmai S. Rai, Indira Bairy, Mohandas K. G. Rao, et al. "Assessment for learning: a needs analysis study using formative assessment to evaluate the need for curriculum reform in basic sciences." Advances in Physiology Education 42, no. 3 (September 1, 2018): 482–86. http://dx.doi.org/10.1152/advan.00093.2018.
Повний текст джерелаАнотація:
A needs analysis study for curriculum reform in basic sciences was conducted at Melaka Manipal Medical College, India, by means of a formative assessment method, namely Basic Science Retention Examination (BSRE). Students participated in a BSRE, which comprised recall and clinical multiple-choice questions in six discipline areas. They also rated the clinical relevance of each question and provided responses to three open-text questions about the exam. Pass rates were determined; clinical relevance ratings and performance scores were compared between recall type and clinical questions to test students’ level of clinical application of basic science knowledge. Text comments were thematically analyzed to identify recurring themes. Only one-third of students passed the BSRE (32.2%). Students performed better in recall questions compared with clinical questions in anatomy (51.0 vs. 40.2%), pathology (45.1 vs. 38.1%), pharmacology (41.8 vs. 31.7%), and biochemistry (43.5 vs. 26.9%). In physiology, students performed better in clinical questions compared with the recall type (56.2 vs. 45.8%). Students’ response to BSRE was positive. The findings imply that transfer of basic science knowledge was poor, and that assessment methods should emphasize clinical application of basic science knowledge.
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Wang, Xiaona, Jun Chen, Hui Xiong, and Xuhui Yu. "Genotype-phenotype associations in familial exudative vitreoretinopathy: A systematic review and meta-analysis on more than 3200 individuals." PLOS ONE 17, no. 7 (July 13, 2022): e0271326. http://dx.doi.org/10.1371/journal.pone.0271326.
Повний текст джерелаАнотація:
Objective To systematically review the relationship between genotypes and clinical phenotypes of Familial exudative vitreoretinopathy (FEVR) to support risk estimation and therapeutic decisions. Design Systematic review with meta-analysis. Data sources The data of our study were collected from PubMed, Embase, Web of Science, Cochrane, CBM, China National Knowledge Infrastructure (CNKI), WAN FANG and VIP databases since inception to August 2021. Results A total of 3257 patients from 32 studies were included according to the inclusion and exclusion criteria. Among all the cases, the mutation frequencies of LRP5, FZD4, NDP, TSPAN12, ZNF408 and KIF11 were 13.6%, 11.5%, 4.6%, 6.7%, 1.6%, and 5.7%, respectively. We found that the patients with NDP and FZD4 suffer more severe symptoms, among which 86.4% patients of NDP and 78.6% patients of FZD4 were in the advanced stage of FEVR. Retinal detachment is the most frequent symptom with patients of LRP5 and NDP mutations, accounting for 51.9% and 64.5%, respectively. For the patients with the mutation of TSPAN12, retinal fold is the most common clinical manifestation, and suffer the mildest clinical phenotypes compared with the other three genes. Conclusion The results of the meta-analysis indicate that different types of genetic mutations occur at different frequencies. In addition, the clinical manifestations of FEVR are related to the type of gene mutation. Therefore, targeted treatment strategies and follow-up recommendations should be adopted for different pathogenic genes of FEVR.
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Mehrnoush, Vahid, Shahrzad Keramati, Asmaa Ismail, Waleed Shabana, Ahmed Zakaria, Hazem Elmansy, Walid Shahrour, Owen Prowse, and Ahmed Kotb. "Adverse pathological outcomes of patients with de novo muscle invasive bladder cancer in Northern Ontario." Archivio Italiano di Urologia e Andrologia 94, no. 1 (March 29, 2022): 41–45. http://dx.doi.org/10.4081/aiua.2022.1.41.
Повний текст джерелаАнотація:
Objective: This study aimed to investigate the clinical and pathological characteristics of patients with de novo muscle-invasive bladder cancer (MIBC) who underwent radical cystectomy in Northern Ontario. Methods: This is a retrospective cross-sectional study of patients with de novo T2 MIBC who underwent radical cystectomy over a 2-year-period in Thunder Bay Regional Health Sciences Centre. Clinical and pathological characteristics of Trans Urethral Resection of Bladder Tumors and cystectomy specimens were analyzed. Results: Of the 59 patients aged 67 ± 8.8 years, predominated by males (80%), 27.1% were younger than age 60. After surgery, upstaging was noted in 59.3% (T3 in 27.1% and T4 in 32.2%) while node positive was noted in 36% of patients. Prostate adenocarcinoma was incidentally discovered in 20 (34%) of patients with 50% considered significant (Gleason score ≥ 7). Downstaging was found in those who had neoadjuvant chemotherapy (p = 0.001). Conclusions: The high prevalence of younger ages (less than 60), a high rate of upstaging, the presence of high-grade incidental prostate cancer, and lymph node positives in T2 de novo MIBC in Northern Ontario, warrants further investigation of potential causes and risk factors at individual, public, and population health levels in the region.
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Dey, Joydeep, and Sunil Karforma. "Unsynchronized Ann & Genetics Guided Telecardiology Security Reinforcement in the Light of Covid-19." Journal of Mathematical Sciences & Computational Mathematics 3, no. 2 (January 3, 2022): 142–55. http://dx.doi.org/10.15864/jmscm.3201.
Повний текст джерелаАнотація:
In this COVID-19 crucial stage, cryptographic developments help to convey secret information inside the digital telemedicine frameworks. The novel corona virus had broken all configurations of our life. In the clinical medical sciences, patients are encouraged to select the remote based telemedicine services. Cardiac patients are especially defenseless to this COVID-19. Patients having Chronic Obstructive Pulmonary Diseases (COPDs) as co-morbidity are enthusiastically prescribed to remain protected at their remote isolations. Through such telecardiology, they might impart their basic data with various cardiovascular experts. This will diminish their odds of getting COVID-19 positive because of no actual developments outside homes. Patients experiencing such significant COPDs are to be analyzed and treated appropriately via cardiologists. Contemporary imperfections on patients' private data are an open challenge in such telecardiology. Electronic cardiac data are very much vulnerable in nature. Along these lines, it is exceptionally critical to force a high level security strategy in such COVID-19 telecardiology. In this paper, we have generated session key based on unsynchronized artificial neural networks and genetic algorithm. Two unsynchronized ANNs were considered to have two intermediate keys. These keys were genetically crossover to form the session key. Furthermore, that session key would e used in the secret share generation process. Entropy values observed with respect to the secret share were nearly closed to eight. Histogram, floating frequency, and autocorrelation, etc were generated by the proposed technique with well-distributed in shapes. The functional time in the form of encryption and decryption were evaluated in this paper for different secret shares. Patients' medical data are very much under severe risk of intrusion. Lastly, secret shares were transmitted through RSA. This framework acts against various security conducts in correspondence network particularly where online clinical exchanges have overflowed colossally in this COVID-19 period.
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Siddiqui, Ruqaiyyah, Mehwish Sagheer, and Naveed Ahmed Khan. "Prevalence of Acanthamoeba and superbugs in a clinical setting: coincidence or hyperparasitism?" Parasitology Research 112, no. 3 (November 24, 2012): 1349–51. http://dx.doi.org/10.1007/s00436-012-3202-5.
Повний текст джерела
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Pallari, Elena, Tayana Soukup, Andri Kyriacou, and Grant Lewison. "Assessing the European impact of alcohol misuse and illicit drug dependence research: clinical practice guidelines and evidence-base policy." Evidence Based Mental Health 23, no. 2 (March 30, 2020): 67–76. http://dx.doi.org/10.1136/ebmental-2019-300124.
Повний текст джерелаАнотація:
BackgroundDespite alcohol and illicit drug dependence being one of the most common diagnoses in Europe, there is heterogeneity of research evidence used in policy and practice.ObjectiveWe sought to (1) evaluate European research outputs on alcohol misuse and drug addiction in 2002–2018 in the Web of Science, (2) compare these with their burden of disease and (3) determine their impact in several ways.MethodsA bibliometric research was undertaken including an assessment of the citation counts, the influence of research on members of national health advisory committees, and their contribution to the evidence base of clinical practice guidelines (CPGs).FindingsThere were 3201 analysed references cited in 28 CPGs across 11 European Countries on alcohol misuse and illicit drug abuse. Research conducted in the USA dominated both sets of CPGs, while many European countries were overcited relative to their research presence. The illicit drug research appeared to be adequate relative to the evidence of harm in Europe. However, alcohol misuse research appeared grossly inadequate to the harm it causes by a factor of 20.ConclusionsThe volume of research on illicit drug addiction is commensurate to the European burden, whereas alcohol misuse is far below what is needed to curb a significant source of harm.Clinical implicationsThe research asymmetries call for attention to the causes of the problem. Development of research-based solutions to a serious social harm is needed, including minimum pricing and collaborative work to harmonise efforts on disease management and treatment practices across European countries.
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Bateman, D. "Mosby's color atlas and text of Neurology, 2nd edition.: Edited by G D Perkin (Pp 324, pound28.95). Published by Elsevier Science, London, 2002. ISBN 0 7234 3208 2." Journal of Neurology, Neurosurgery & Psychiatry 73, no. 5 (November 1, 2002): 606—b—606. http://dx.doi.org/10.1136/jnnp.73.5.606-b.
Повний текст джерела
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Pradhan, Shanti, Sanjib Mani Regmi, and Nabina Shrestha. "Inducible Clindamycin Resistant Staphylococcus aureus among Patients Attending Tertiary Care Centre: A Descriptive Cross-sectional Study." Journal of Nepal Medical Association 59, no. 243 (November 15, 2021): 1111–15. http://dx.doi.org/10.31729/jnma.6882.
Повний текст джерелаАнотація:
Introduction: Staphylococcus aureus, a superbug, resistant to multiple antibiotics led to growing interest in the usage of macrolide-lincosamide-streptogramin B antibiotics, which are now rapidly developing resistance. This study aims to find the prevalence of inducible clindamycin-resistant Staphylococcus aureus among obtained clinical samples from in-patient and out-patient departments of a tertiary care center. Methods: This is a descriptive cross-sectional study done in clinical samples from the in-patient and out-patient departments of a tertiary care center from September 2020-May 2021. Ethical clearance was taken from the Institutional Review Committee (Ref: 068/2077/2078). Staphylococcus aureus were isolated and antibiotic susceptibility tests were performed by disc diffusion method. Inducible clindamycin and methicillin resistance Staphylococcus aureus were detected using D-test and cefoxitin disc according to Clinical and Laboratory Standards Institute guidelines. Convenient sampling was done and the data was analyzed using Statistical Package for Social Sciences version 20. Point estimate at 95% confidence interval was calculated along with frequency and proportion for binary data. Results: Among a total of 141 Staphylococcus aureus isolated, the prevalence of inducible clindamycin resistant phenotype was 41 (29.1%) (21.6-36.59 at 95% Confidence Interval). Whereas, 30 (21.3%) were constitutive clindamycin resistant. The inducible 28 (47.5%) and 19 (32.2%) constitutive clindamycin resistance was higher among methicillin-resistant Staphylococcus aureus. Conclusions: The frequency of inducible clindamycin resistance among methicillin resistant Staphylococcus aureus was high, which alarms the use of macrolide-lincosamide-streptogramin B antibiotics in Staphylococcus aureus infections. Hence, D-test should be performed to detect inducible clindamycin resistance in routine testing to prevent treatment failure.
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Sassine, S., S. Fadela Zekhnine, M. Qaddouri, L. Djani, C. Cambron-Asselin, M. Savoie-Robichaud, Y. Lin, et al. "A188 FACTORS ASSOCIATED WITH CLINICAL REMISSION IN PEDIATRIC LUMINAL CROHN’S DISEASE: A RETROSPECTIVE COHORT STUDY." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (February 21, 2022): 71–72. http://dx.doi.org/10.1093/jcag/gwab049.187.
Повний текст джерелаАнотація:
Abstract Background The natural evolution of Crohn’s disease is incompletely understood in the pediatric population. Data on factors influencing time-to-remission are very limited in the literature. Aims The aim of this retrospective cohort study was to describe the time to clinical remission in children with Crohn’s disease as well as changes over the past decade and to identify factors associated with time to clinical remission. Methods Patients under 18 years old diagnosed between 2009 and 2019 were included. All data were collected from the patients’ medical records and the CHU Sainte-Justine inflammatory bowel disease registry. Survival analyses and linear regression models were used to assess the impact of clinical, laboratory, endoscopic, histological and therapeutic factors on time to clinical remission. Results 654 patients were included in the study. There was no change in the time to clinical remission over the past decade. Female sex in adolescents (ajusted bêta regression coefficient (aβ)= 31.8 days, p= 0.02), upper digestive tract involvement (aβ= 46.4 days, p= 0.04), perianal disease (aβ= 32.2 days, p= 0.04), presence of active inflammation on biopsies (aβ= 46.7 days, p= 0.01) and oral 5-ASA exposure (aβ=56.6 days, p= 0.002) were all associated with longer time to clinical remission. However, antibiotic exposure (aβ= -29.3 days, p=0.04), increased eosinophils on biopsies (aβ= -29.6 days, p=0.008) and combination of exclusive enteral nutrition and TNF- alpha inhibitors as induction therapy (aβ= -36.8, p=0.04) were associated with shorter time to clinical remission. Conclusions Time to clinical remission did not improve during the decade and was associated with baseline clinical and histological data and treatment strategies. Combination of enteral nutrition and TNF-alpha inhibitors was associated with faster clinical remission. Kaplan-Meier curve representing the time to clinical remission of patients according to the first induction treatment administered. Funding Agencies NoneFonds Recherche Santé Québec / Fondation du CHU Sainte-Justine
Дисертації з теми "3202 Clinical sciences"
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Bass, Christopher. "Positron Emission Tomography for Pre-Clinical Sub-Volume Dose Escalation." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3202.
Повний текст джерелаАнотація:
Purpose: This dissertation focuses on establishment of pre-clinical methods facilitating the use of PET imaging for selective sub-volume dose escalation. Specifically the problems addressed are 1.) The difficulties associated with comparing multiple PET images, 2.) The need for further validation of novel PET tracers before their implementation in dose escalation schema and 3.) The lack of concrete pre-clinical data supporting the use of PET images for guidance of selective sub-volume dose escalations. Methods and materials: In order to compare multiple PET images the confounding effects of mispositioning and anatomical change between imaging sessions needed to be alleviated. To mitigate the effects of these sources of error, deformable image registration was employed. A deformable registration algorithm was selected and the registration error was evaluated via the introduction of external fiducials to the tumor. Once a method for image registration was established, a procedure for validating the use of novel PET tracers with FDG was developed. Nude mice were used to perform in-vivo comparisons of the spatial distributions of two PET tracers, FDG and FLT. The spatial distributions were also compared across two separate tumor lines to determine the effects of tumor morphology on spatial distribution. Finally, the research establishes a method for acquiring pre-clinical data supporting the use of PET for image-guidance in selective dose escalation. Nude mice were imaged using only FDG PET/CT and the resulting images were used to plan PET-guided dose escalations to a 5 mm sub-volume within the tumor that contained the highest PET tracer uptake. These plans were then delivered using the Small Animal Radiation Research Platform (SARRP) and the efficacy of the PET-guided plans was observed. Results and Conclusions: The analysis of deformable registration algorithms revealed that the BRAINSFit B-spline deformable registration algorithm available in SLICER3D was capable of registering small animal PET/CT data sets in less than 5 minutes with an average registration error of .3 mm. The methods used in chapter 3 allowed for the comparison of the spatial distributions of multiple PET tracers imaged at different times. A comparison of FDG and FLT showed that both are positively correlated but that tumor morphology does significantly affect the correlation between the two tracers. An overlap analysis of the high intensity PET regions of FDG and FLT showed that FLT offers additional spatial information to that seen with FDG. In chapter 4 the SARRP allowed for the delivery of planned PET-guided selective dose escalations to a pre-clinical tumor model. This will facilitate future research validating the use of PET for clinical selective dose escalation.
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Rodríguez, Vivian M. "The Role of Family Organization in Family Health History Communication about Cancer." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3201.
Повний текст джерелаАнотація:
Family health history (FHH) has been recognized as an important tool in cancer prevention and health promotion. To date, literature on FHH discussions about cancer have largely focused on patient-physician communication or the dissemination of cancer-specific genetic tests results within the family. Fewer studies have sought to identify family factors that may promote FHH discussions, yet this type of information could be used to identify families needing support in having these conversations. Thus, the present study examined relations between family organization (cohesion and flexibility), communication openness, and FHH communication about cancer within a diverse group of women recruited from an urban, safety-net women's health clinic. Participants were enrolled in a randomized control trial examining the effects of an educational intervention on family communication about hereditary breast and colon cancers (Kin Fact Study). For the present study, baseline survey data for 472 women were analyzed. Participants completed measures on demographics, family organization, communication openness, and FHH communication. Average age was 34 years and 59% reported being Black. Thirty-one percent had graduated high school and 28% reported having commercial health insurance. Seventy-five percent of women reported a family history of cancer in a first or second degree relative. Descriptive statistics, correlations, and multiple linear regression and hierarchical logistic regressions, adjusting for key factors, were performed. Nineteen percent of women actively collected FHH information about cancer and 11% reported actively sharing cancer risk information with relatives. Being older, having a greater educational attainment, and having a family history of cancer was associated with having collected FHH; while being older and reporting higher levels of cohesion/flexibility was associated with sharing cancer risk information. Adjusting for demographic variables, cohesion, flexibility, and openness were not significant predictors of collecting or sharing FHH. Family history of cancer did not moderate the relationship between family organization and FHH. Cohesion and flexibility levels did significantly predict communication openness. This study contributes to a small but emergent literature in the field of FHH communication about cancer as it explores family context factors that may aid in the development of prevention interventions. Clinical implications and directions for future research are discussed.
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Martin, Aaron. "THE ROLE OF PAIN-RELATED CATASTROPHIZING IN OUTCOMES AND RECOVERY FROM MINIMALLY INVASIVE AND SURGICAL PROCEDURES FOR TREATING TEMPOROMANDIBULAR DISORDERS." VCU Scholars Compass, 2013. http://scholarscompass.vcu.edu/etd/3203.
Повний текст джерелаАнотація:
The current study examined the ability of pain-related catastrophizing to predict outcomes following non-surgical and surgical intervention for temporomandibular disorders (TMDs). The interpersonal context of pain-related catastrophizing, referred to as the communal coping model, was also examined to determine if patient perceptions of punishing and solicitous responses from significant others would moderate or mediate relations between pain catastrophizing and outcomes. The role of pain duration as a moderator of the relation between pain-related catastrophizing and perceived significant other responding was also examined. A total of 94 patients were identified for which 65 had follow-up outcomes that could be examined. Patient follow-up data were obtained at approximately two to three weeks, two to three months, and six months post-intervention. Results showed that pain-related catastrophizing was predictive of greater pain severity at all three follow-up time points after controlling for baseline levels of pain severity, depressive symptoms, sleep disturbance, and pain duration. Pain-related catastrophizing was predictive of poorer range of motion (ROM) at the initial follow-up after controlling for baseline levels of ROM, gender, and form of intervention. Pain-related catastrophizing was not associated with ROM at the second and third post-intervention follow-ups. There was no interaction between pain-related catastrophizing and perceptions of either solicitous or punishing responses in predicting post-intervention pain severity or ROM and any time point. Perceptions of significant other responses also did not mediate the relation between pain-related catastrophizing and post-intervention outcomes at any time point. Additionally, the interaction between pain duration and pain-related catastrophizing in the prediction of post-intervention pain severity or ROM was not significant at any follow-up time point. The findings indicate that pain related catastrophizing is an important predictor of pain severity following non-surgical and surgical interventions for TMDs both initially and in the long-term. Pain-related catastrophizing is related to ROM outcomes only in the short term. Perceptions of punishing and solicitous responses from significant others do not appear to play a role in these associations. The results suggest that patients with high levels of pre-intervention catastrophizing may benefit from adjunctive cognitive-behavioral intervention to attenuate post-intervention pain severity.
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Guo, Yanping. "The mechanism of Nov (CCN3) function in haematopoiesis." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:5785f3b9-3206-4bb4-b486-d90cded680f8.
Повний текст джерелаАнотація:
Haematopoietic stem cells (HSC) are strictly regulated by intrinsic regulators and extrinsic signals from the microenvironment. Nov (CCN3), a matricellular protein of the CCN family, has been reported as a suppressor gene in solid tumours and chronic myeloid leukaemia (CML). Recent study identified Nov as a positive regulator in human cord blood CD34+ stem cells. However, the functions of Nov in haematopoiesis and adult HSC remain largely unknown.
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Macfarlane, Christopher. "Actions Speak Louder Than Words: Exploring Pragmatism in Osteopathy." Thesis, 2021. https://vuir.vu.edu.au/42498/.
Повний текст джерелаАнотація:
Purpose: To develop a conception of osteopathic practice that assists in defining the profession. Practices by those who comprise a profession are representative of the profession. As such, practices of professional osteopaths were analysed: what they were and how they were conducted, to develop a conception of practice. The key research questions were: What role does clinical reasoning play in defining osteopathic practice? What are the acts that constitute osteopathic clinical practice? How might Pragmatism provide a philosophy that informs the principles and practice of osteopathy? Can Pragmatism provide a bridge to the issues within osteopathy?
Method: Pragmatism provided the epistemology with meaning occurring from socially situated acts. Fifteen Australian registered osteopathic practitioners volunteered to have their practice videoed and then respond to a semi-structured interview. The interview addressed questions about the acts that occurred in the consult, with the video recording as a prompt. The transcripts were interpreted, coded and the emergent themes from all transcripts were then pooled and coded to develop knowledge themes.
Conclusions: Osteopathic practice is a professional social behaviour that interprets a patient’s concerns with a series of gestures and acts to construct a shared meaning as a basis for ongoing acts that are aligned with establishing meaning relating to the sensitising impulse. Key to these gestures and acts is a structured organised approach that consists of social praxis that supports the conducting of phronesis in the betterment of society. The professional social behaviour contains within it all that is the osteopathic profession and is focused on an individualized experience that occurs within the consult, as the key vehicle of the acts of the profession.
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Sizonenko, Stéphane Vladimir. "Hypoxic-ischemic injury in the developing brain: pathogenesis and neuroprotection." 2002. http://hdl.handle.net/2292/3212.
Повний текст джерелаАнотація:
In newborn infants, birth asphyxia represents the predominant cause of brain injury. These infants will later exhibit neurodevelopmental disabilities or a more major cerebral palsy. Prevention of adverse outcomes requires an understanding of the way in which these deficits develop. Endogenous protective mechanisms arising from the insult have opened new insights in neuroprotective strategies. Neurotrophic factors such as IGF-1 and its N-terminal tripeptide GPE have been shown to confer some neuroprotection after HI injury in the adult rodent. In the P21 rat brain after moderate HI injury, exogenous intracerebral and intraperitoneal injections of GPE (30μg and 300μg respectively) were neuroprotective in the hippocampus and lateral cortex possibly through binding to glia as detected by autoradiography of 3H-GPE. In the preterm infant the mechanisms of white matter injury remain to be clearly elucidated. To mimic the pattern of diffuse cerebral injury of the very preterm infant, a transient moderate focal HI injury has been applied on the immature P3 rat. This new model showed a significant reduction in the lateral cortical volume with reduction and alteration of the myelination pattern in the cortical white matter (WM) at P21. These cortical alterations result from neuro-axonal damage 24h after the insult as shown with Fluoro-Jade B staining and β-APP accumulation. In addition activated astrocytes from 24h after HI up to P21 were present. This model should enable us to elucidate some of the pathogenic mechanisms involved in diffuse WM injury. Brain damage in the developing brain has two components: 1) the pattern and mechanisms of injury are correlated with the stage of development at the time of injury; 2) it will influence subsequent brain development.
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Pudkasam, Supa. "Physical activity motivation and self-directed physical activity in female breast cancer survivors." Thesis, 2021. https://vuir.vu.edu.au/42516/.
Повний текст джерелаТези доповідей конференцій з теми "3202 Clinical sciences"
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Smith, Stephen, and Samuel Sambasivam. "Web Based Data Capture for Clinical Research." In InSITE 2008: Informing Science + IT Education Conference. Informing Science Institute, 2008. http://dx.doi.org/10.28945/3201.
Повний текст джерелаАнотація:
Electronic Data Capture (EDC) is increasingly being used in the pharmaceutical, biotech and medical device industries to gather research data worldwide from doctors, hospitals and universities participating in clinical trials. In this highly regulated environment, all systems and software must be thoroughly tested and validated, a task that is burdensome in terms of time and cost. Starting with database structures that are designed to be copied easily, this paper proposes a simple framework that allows for rapid development and minimal testing. The framework includes tools for building modules, for copying modules from one trial to the next, and tools to validate that the modules are the same as modules that have been fully tested previously. A proof-of-concept prototype has been built to demonstrate certain tools and techniques that can be used when designing and building a simplified EDC interface.