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Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Semenova, Lioubov I., and Allan H. White. "Structural Systematics of Rare Earth Complexes. XVII Hydrated 1 : 1 Adducts of 2,2′:6′,2″-Terpyridine with the Lanthanoid(III) Bromides and Some Binuclear Hydroxy-Bridged Dimers." Australian Journal of Chemistry 52, no. 6 (1999): 539. http://dx.doi.org/10.1071/ch98048.

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Room-temperature single-crystal X-ray structural characterizations are recorded for hydrated lan- thanoid(III) bromide/2,2′:6′,2″-terpyridine (tpy) (1 : 1) complexes, showing all to be ionic and of the form [(tpy)Ln(OH2)x]Br3.yH2O, where x and y are 6 and 1 for the isomorphous series Ln = La(-)Er (and intermediate members, by presumption), and 5 and various values for Ln = Tm, Yb, Lu. Crystals of [(tpy)Ln(OH2)6]Br3.H2O are monoclinic, P 21/c, a ≈ 8·5, b ≈ 18, c ≈ 16·3 Å, β ≈ 108°, Z = 4; for Ln = La, Er, conventional R values on |F| were 0·048, 0·080 for No 4027, 1347 ‘observed’ (I > 3σ(I))

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2

Rousseau, Romain, Charlotte Labruyere, Charles Kajetanek, Olivia Deschamps, Konstantinos G. Makridis, and Patrick Djian. "Complications After Anterior Cruciate Ligament Reconstruction and Their Relation to the Type of Graft: A Prospective Study of 958 Cases." American Journal of Sports Medicine 47, no. 11 (2019): 2543–49. http://dx.doi.org/10.1177/0363546519867913.

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Background: Complications and adverse events after anterior cruciate ligament (ACL) reconstruction are well known, but they have been underestimated in previous studies. Purpose: To describe the complications and adverse events after ACL reconstruction within a 2-year follow-up and analyze them in relation to the type of graft. Study Design: Cohort study; Level of evidence, 3. Methods: From 2000 to 2012, 958 patients with an isolated ACL injury underwent surgery by a single knee surgeon. ACL reconstruction was performed with the medial portal technique for the femoral tunnel and the use of bon

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3

BHANUSHALI, APARNA A., AASHISH CONTRACTOR, and BIBHU R. DAS. "Variant at 9p21 rs1333049 is associated with age of onset of coronary artery disease in a Western Indian population: a case control association study." Genetics Research 95, no. 5 (2013): 138–45. http://dx.doi.org/10.1017/s0016672313000189.

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SummaryThe 9p21 chromosomal region has been associated with coronary artery disease (CAD) in many genome wide association studies (GWAS). To date no information exists regarding the rs1333039 SNP which showed the strongest association in the WTCCC GWAS with CAD risk in the Indian population. The present study attempts to replicate the findings in the Indian population.Genotyping for rs1333049 was done in 229 cases and 151 controls by allele-specific real-time assay.A higher frequency of the risk allele rs1333049C was seen in cases (0·60) as compared with controls (0·49), which associated with

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4

Giurlani, Walter, Margherita Verrucchi, Marco Bonechi, Giovanni Zangari, and Massimo Innocenti. "Advancements in Analyzing Organic Additives in Electroplating Baths: A Focus on Electrochemical Impedance Spectroscopy (EIS) Coupled with Distribution of Relaxation Times (DRT)." ECS Meeting Abstracts MA2024-02, no. 22 (2024): 1892. https://doi.org/10.1149/ma2024-02221892mtgabs.

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Organic additives play a crucial role in upholding the quality of metallic coatings within commercial electroplating baths. However, their effectiveness diminishes over time due to degradation and drag-out. Continuous monitoring and precise dosing are imperative to uphold optimal concentration levels, preserving both technical integrity and aesthetic appeal. Traditional chromatographic techniques are impractical for routine industrial analysis due to the complex formulation and synergistic effects of various additives. Electrochemical methods, such as the Hull cell test and Cyclic Voltammetric

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5

Zeidler, Peter, Elena Sabbi, and Antonella Nota. "The Internal Line-of-Sight Kinematics of NGC 346: The Rotation of the Core Region." Astrophysical Journal 936, no. 2 (2022): 136. http://dx.doi.org/10.3847/1538-4357/ac8004.

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Abstract We present the stellar radial velocity analysis of the central 1 ′ × 1 ′ of the young massive Small Magellanic Cloud star cluster NGC 346. Using VLT/MUSE integral field spectroscopy in combination with Hubble Space Telescope photometry, we extract 103 spectra of cluster member stars suited to measure accurate line-of-sight kinematics. The cluster member stars show two distinct velocity groups at v 1 = − 3.3 − 0.2 + 0.3 km s − 1 and v 2 = 2.6 − 0.1 + 0.1 km s − 1 , relative to the systemic velocity of (165.5 ± 0.2) km s−1, and hint at a third group at v 3 = 9.4 − 0.1 + 0.1 km s − 1 . W

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6

Giurlani, Walter, Margherita Verrucchi, Ivan del Pace, et al. "Innovative EIS-DRT for Monitoring Organic Additives in Copper Electroplating Baths." ECS Meeting Abstracts MA2025-01, no. 23 (2025): 1432. https://doi.org/10.1149/ma2025-01231432mtgabs.

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The performance and longevity of metallic coatings produced in electroplating baths are heavily dependent on the presence of organic additives. However, these additives are susceptible to degradation and loss, necessitating regular monitoring to ensure consistent quality and aesthetic standards. Conventional chromatographic techniques are often unsuitable for industrial settings due to the intricate composition of the baths and the interplay between various additives. Electrochemical methods such as the Hull cell test and Cyclic Voltammetric Stripping (CVS) are widely employed to assess and ma

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7

Albero, G., V. Longobardi, G. Zullo, et al. "144 INFLUENCE OF REPEATED OVUM PICKUP ON BUFFALO WELFARE." Reproduction, Fertility and Development 26, no. 1 (2014): 185. http://dx.doi.org/10.1071/rdv26n1ab144.

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The aim of this work was to evaluate the effect of repeated ovum pickup (OPU) on buffalo welfare. The OPU was carried out as previously described (Neglia et al. 2003 Theriogenology 59, 1123–1130) twice per week on 11 buffalo cows at 121 ± 15 days in milk for 2 months (end of October–end of December). Blood samples were collected before the beginning of the trial (time 0), after 1 month (time 1), and after 2 months (time 2) in animals that had undergone OPU and in control animals (n = 10) of the same herd. The following parameters of clinical immunology were evaluated on sera: haemolytic comple

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8

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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9

Zammit, Gary, David Mayleben, Ingo Fietze, et al. "344 Daridorexant Improves Total Sleep Time (TST) in Insomnia Patients Without Altering the Proportion of Sleep Stages." Sleep 44, Supplement_2 (2021): A137—A138. http://dx.doi.org/10.1093/sleep/zsab072.343.

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Abstract Introduction Daridorexant, a new dual orexin receptor antagonist, improved sleep parameters and daytime functioning in two pivotal Phase 3 trials in patients with insomnia (Trial-1, NCT03545191; Trial-2, NCT03575104); polysomnography data were collected at multiple timepoints from &gt;1,800 patients. We report the effects of daridorexant on TST and sleep stages from both trials. Methods Eligible patients with insomnia (according to DSM-5) were randomized (1:1:1) in Trial-1 (N=930) to daridorexant 25mg, 50mg, or placebo and in Trial-2 (N=924) to daridorexant 10mg, 25mg, or placebo.

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10

Hendriks, Steven H., Dennis Schrijnders, Kornelis JJ van Hateren, et al. "Association between body mass index and obesity-related cancer risk in men and women with type 2 diabetes in primary care in the Netherlands: a cohort study (ZODIAC-56)." BMJ Open 8, no. 1 (2018): e018859. http://dx.doi.org/10.1136/bmjopen-2017-018859.

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ObjectiveTo investigate the relationship between body mass index (BMI) and obesity-related cancers in men and women with type 2 diabetes (T2D).DesignObservational cohort study.SettingPrimary care.ParticipantsA total of 52 044 patients with T2D who participated in the ZODIAC (Zwolle Outpatient Diabetes project Integrating Available Care) study between 1998 and 2012 was included (49% women). A dataset of these patients was linked to available information of the Netherlands Cancer Registry to obtain data on cancer incidents.Primary outcome measuresAnalyses were performed for the total group of ob

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11

Tomizawa, Daisuke, Akio Tawa, Tomoyuki Watanabe, et al. "Appropriate Dose Modification in Induction Therapy Is Essential for the Treatment of Infants with Acute Myeloid Leukemia; A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG)." Blood 120, no. 21 (2012): 2615. http://dx.doi.org/10.1182/blood.v120.21.2615.2615.

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Abstract Abstract 2615 Background: Infants (age <1 year) with AML are naturally vulnerable to intensive cytotoxic therapy, and we have previously reported unacceptably high early death rate mainly due to pulmonary complications among the first 32 infants (28 eligible) enrolled in the JPLSG AML-05 study, which prompted us to suspension of patient accrual and protocol amendment (Tomizawa D. 52ndASH abstract #2146). Seventeen additional infants were enrolled after the amendment, and here we report the final outcome of total 45 infants with AML treated on AML-05 study. Patients & Methods: J

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12

Lâm, Hưng Hiệp, Công Kiệt Nguyễn та Xuân Thảo Nguyễn. "Đánh giá kết quả điều trị tổn thương mắt cấp tính trên bệnh nhân dị ứng thuốc mức độ nặng". Y HOC TP. HO CHI MINH 28, № 5 - Y hoc 2025 (2025): 146–53. https://doi.org/10.32895/hcjm.m.2025.05.19.

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Mục tiêu: (1) Xác định tỉ lệ mức độ tổn thương mắt trên bệnh nhân dị ứng thuốc mức độ nặng trong giai đoạn cấp tính; (2) Kết quả của việc điều trị tổn thương mắt trên bệnh nhân dị ứng thuốc mức độ nặng trong giai đoạn cấp tính; (3) Đánh giá di chứng mắt mạn tính trên bệnh nhân dị ứng thuốc mức độ nặng tại bệnh viện Chợ Rẫy bắt đầu từ tháng 12/2023 đến tháng 6/2024. Đối tượng và phương pháp nghiên cứu: Nghiên cứu tiến cứu mô tả hàng loạt ca, trên 64 mắt của 32 bệnh nhân từ 18 tuổi trở lên đã được chẩn đoán xác định tổn thương mắt do dị ứng thuốc mức độ nặng và được điều trị tại khoa Nhiệt Đới

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13

Erblang, M., M. Quiquempoix, A. Vergez, et al. "0299 Total Sleep Deprivation and Time on Task: Not the Same for Sustained Attention and Executive Processes and Poor Benefit of Caffeine." Sleep 43, Supplement_1 (2020): A113. http://dx.doi.org/10.1093/sleep/zsaa056.296.

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Abstract Introduction Mental Fatigue is commonly questioned regarding time on task or sleep debt effect (Hockey, 2013; Pattyn et al., 2018) or sleep debt effect (Krause et al., 2017). No studies have neither investigated contributions of these two factors for different cognitive processes nor benefit of caffeine. Methods 24 right-handed and healthy subjects (18–50 years old), with a median chronotype and sleep need participated in a 2-experimental counter-balanced (placebo: PBO and caffeine: COFFEE - 2.5 mg/kg) total sleep deprivation protocol (TSD = 27 hours of continuous wakefulness). Subjec

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14

Bryan, Marta L., and Eve J. Lee. "Resolving the Super-Earth/Gas Giant Connection in Stellar Mass and Metallicity." Astrophysical Journal Letters 982, no. 1 (2025): L7. https://doi.org/10.3847/2041-8213/adb0bd.

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Abstract The observed correlation between inner super-Earths (SE) and outer gas giants (GG) places strong constraints on formation theories. Building on previous work, M. L. Bryan & E. J. Lee showed that there is a statistically significant positive correlation between super-Earths and outer gas giants around metal-rich FGK stars, and that this correlation disappears for metal-poor hosts. Here we consider how this connection evolves across stellar mass. Starting with our sample of 85 M dwarfs (<0.6 M ⊙) hosting inner super-Earths, we calculate P(GG∣SE, [Fe/H] > 0) = 9.4 (+10.2 −3.1)%

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15

Minor, Maria, Michal Nisnboym Ziv, Mallika Patel, et al. "INNV-31. THE USE OF IVOSIDENIB IN PATIENTS WITH ENHANCING IDH1 MUTANT GLIOMAS." Neuro-Oncology 26, Supplement_8 (2024): viii175. http://dx.doi.org/10.1093/neuonc/noae165.0693.

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Abstract Ivosidenib offers a novel targeted therapy for non-enhancing IDH1 mutated gliomas following initial resection. Potential effects of IDH inhibitors on enhancing disease in clinical settings are not well established. This study characterizes a cohort of patients with IDH1 mutated gliomas with enhancing disease, who were initiated on monotherapy, off-label ivosidenib between October, 2020 to August, 2023. The cohort included 21 patients ages 29 to 73 years, 11 female and 10 male. Diagnoses represented were astrocytoma IDH1 mutant, grade 2-4 (N=9) and oligodendrogliomas IDH1 mutant, grade

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16

Bersanelli, Melissa, Diana Giannarelli, Ugo De Giorgi, et al. "Symptomatic COVID-19 in advanced-cancer patients treated with immune-checkpoint inhibitors: prospective analysis from a multicentre observational trial by FICOG." Therapeutic Advances in Medical Oncology 12 (January 2020): 175883592096846. http://dx.doi.org/10.1177/1758835920968463.

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Background: This prospective, multicentre, observational INVIDIa-2 study is investigating the clinical efficacy of influenza vaccination in advanced-cancer patients receiving immune-checkpoint inhibitors (ICIs), enrolled in 82 Italian centres, from October 2019 to January 2020. The primary endpoint was the incidence of influenza-like illness (ILI) until 30 April 2020. All the ILI episodes, laboratory tests, complications, hospitalizations and pneumonitis were recorded. Therefore, the study prospectively recorded all the COVID-19 ILI events. Patients and methods: Patients were included in this

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17

Westra, Wytske M., Joel D. Kopple, Raymond T. Krediet, Marilyn Appell, and Rajnish Mehrotra. "Dietary Protein Requirements and Dialysate Protein Losses in Chronic Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 27, no. 2 (2007): 192–95. http://dx.doi.org/10.1177/089686080702700217.

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Background Recommended dietary protein allowances for chronic peritoneal dialysis (PD) patients are approximately 60% higher than the dietary protein allowances for healthy adults. The relative contribution of dialysate protein and amino acid losses to these high protein requirements or total nitrogen losses is uncertain. Methods Following a peritoneal equilibration test, two 24-hour dialysate collections (24–1 and 24–2) were performed in 9 stable patients undergoing automated PD [4 males, 3 diabetics, age 43 ± 5 years (mean ± SEM), dialysis vintage 42 ± 6 months, dialysate-to-plasma ratio of

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18

Charalambous, C., T. A. Barker, C. S. Zipitis, et al. "Comparison of Peripheral and Central Venous Pressures in Critically Ill Patients." Anaesthesia and Intensive Care 31, no. 1 (2003): 34–39. http://dx.doi.org/10.1177/0310057x0303100106.

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We conducted a prospective study to determine the relationship between central (CVP) and peripheral (PVP) venous pressures in critically ill patients. CVP and PVP were measured on five different occasions in 20 critically ill patients in the intensive care unit. Results showed that the mean difference between PVP and CVP was 4.4 mmHg (95% CI= 3.7 to 5.0). However, PVP might be 1.9 mmHg below (95% CI=0.7 to 3.1) or 10.6 mmHg above (95% CI=9.4 to 11.8) the CVP. The mean difference between changes in PVP and corresponding changes in CVP was 0.3 mmHg (95%CI=-0.1 to 0.7). The actual change in PVP c

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19

Shipovskaya, A. A., I. V. Kurbatova та O. P. Dudanova. "Pleiotropic eﬀects of ursodeoxycholic acid in patients with non-alcoholic steatohepatitis with impaired glycemic control". Experimental and Clinical Gastroenterology 183, № 11 (2020): 34–38. http://dx.doi.org/10.31146/1682-8658-ecg-183-11-34-38.

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The goal was to determine the eﬀect of ursodeoxycholic acid (UDCA) in non-alcoholic steatohepatitis (NASH) with impaired glycemic control.Materials and methods. 67 patients NASH were examined: prediabetes — 38 (56.7%), type 2 diabetes mellitus 29 (43.3%), men — 39 (58.2%), women — 28 (41.8%), age — 45.1 ± 10.2 years. The UDCA dose was 9.4 ± 2.0 mg / kg / day during 59.7 ± 77.6 weeks. Fragments of cytokeratin-18 (FCK-18) (TPS ELISA, Biotech, Sweden), TNF-α (Human TNFα Platinum ELISA, eBioscience, Austria), IL-6 (“Interleukin-6-IFA-Best”, Vector-Best, Russia), insulin (“Insulin TEST System”, Mon

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20

Offer, J. E., and N. W. Offer. "Calcium hydroxide treatment of malt distillers' grains 2. Effects on apparent digestibilityin vivo, intake and performance in sheep." Animal Science 55, no. 2 (1992): 209–18. http://dx.doi.org/10.1017/s0003356100037478.

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AbstractThe effects of calcium hydroxide (Ca(OH)2)treatment of malt distillers' grains (MDG) on apparent digestibilityin vivo, food intake and lamb performance were measured in three experiments. Experiment 1 measured effects on intake and apparent digestibility of wet MDG either untreated (C), mineralized with a high-calcium mineral (M), Ca(OH)2treated at ambient temperature (L) or at 70°C for 72 h (LH) and offeredad libitumto mature wether sheep (approx. 75 kg live weight). Dry matter (DM) intakes for MDG were 1251,1585,1838 and 1889 (s.e. 93) g/day for C, M, L and LH respectively when given

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21

Adkoli, Anusha, Krystle Vera, Patrick Glennan, et al. "Participation of patients with gynecological cancer in phase 1 clinical trials: Experience from 2 NCI-Designated Comprehensive Cancer Centers." Journal of Clinical Oncology 42, no. 16_suppl (2024): e17610-e17610. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e17610.

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e17610 Background: Phase 1 trials are intended to define the safety of novel therapeutics, yet they offer alternate options long before they are approved. There is limited data regarding access and participation in phase 1 trials for gynecologic oncology patients. The purpose of this study is to assess the efficacy of phase 1 trials and to study factors of demographics, tumor characteristics, and toxicities impacting this population group. Methods: This IRB approved study was conducted via retrospective chart review at the Rutgers Cancer Institute of New Jersey and the Montefiore Einstein Comp

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22

Alten, R., X. Mariette, R. M. Flipo, et al. "AB0207 ANALYSIS OF ABATACEPT TREATMENT RETENTION AND EFFICACY ACCORDING TO DISEASE DURATION AND TREATMENT LINE IN A REAL-WORLD SETTING." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1128.2–1130. http://dx.doi.org/10.1136/annrheumdis-2021-eular.955.

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Background:Longer disease duration and greater number of prior DMARDs have been associated with lower treatment efficacy in patients with RA.1 Abatacept is a biologic (b)DMARD for treatment of moderate-to-severe RA and is available in SC formulation, which may offer convenience benefits with efficacy similar to IV administration.2 ASCORE (Abatacept SubCutaneOus in Routine Clinical PracticE; NCT02090556) was a 2-year, observational, prospective, multicentre study of SC abatacept for treatment of RA in routine clinical practice.3Objectives:This post hoc analysis was conducted to determine if ret

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23

Ghenim, A., I. Kacem, A. Chouchane, et al. "The neuro-psychological manifestations of COVID-19 in healthcareworkers." European Psychiatry 67, S1 (2024): S149—S150. http://dx.doi.org/10.1192/j.eurpsy.2024.334.

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IntroductionAt the beginning of the Covid-19 pandemic, respiratory expression of SARS-CoV-2 infection was the most worrying one. Later, other symptoms appeared to be more disturbing such as neurological and psychiatric manifestations, which may be due to direct or indirect effects of this virus on the central nervous system.ObjectivesTo assess the prevalence of neuropsychological manifestations of covid-19 in healthcareworkers and to identify their risk factors.MethodsThis is a cross-sectional descriptive epidemiological study, carried out in the teaching hospitals of Farhat Hached and Sahloul

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24

Kurella Tamura, Manjula, Mengjiao Huang, Jaejin An, et al. "SPRINT Treatment Among Adults With Chronic Kidney Disease From 2 Large Health Care Systems." JAMA Network Open 8, no. 1 (2025): e2453458. https://doi.org/10.1001/jamanetworkopen.2024.53458.

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ImportanceIt is unclear whether the effects of intensive vs standard blood pressure (BP) targets seen in clinical trials generalize to patients with chronic kidney disease (CKD) encountered in everyday practice due to differences in the distribution of cardiovascular risk factors and coexisting conditions.ObjectiveTo evaluate whether the beneficial and adverse effects of intensive vs standard BP control observed in the Systolic Blood Pressure Intervention Trial (SPRINT) are transportable to a target population of adults with CKD in clinical practice.Design, Setting, and ParticipantsThis compar

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25

Parab, Panah, Ronit Juthani, and Kala Seetharaman. "Inclusion of patients with reduced performance status (ECOG 2 or higher) in FDA registrational trials for urothelial cancer." Journal of Clinical Oncology 43, no. 5_suppl (2025): 680. https://doi.org/10.1200/jco.2025.43.5_suppl.680.

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680 Background: The Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) is a tool used to describe a cancer patient’s functional status and recruit participants into clinical trials. Clinical trials recruit patients with a good performance status (ECOG 0 or 1) which is not concordant with the real-world population. ASCO-Friends of Cancer Research in a joint statement has recommended the inclusion of patients with reduced PS in clinical trials. We evaluated the inclusion of patients with ECOG 2 or greater in urothelial cancer clinical trials leading to FDA approvals between 2014 a

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26

Do, Cardinal, and Julie Suhr. "2 Examining Gender Differences in the Serial Position Effect and its Relationship to Memory Outcomes." Journal of the International Neuropsychological Society 29, s1 (2023): 861–62. http://dx.doi.org/10.1017/s1355617723010639.

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Objective:There are gender-related disparities in age of diagnosis of Mild Cognitive Impairment (MCI) or dementia, with women often receiving delayed diagnoses compared to men. These delays may be related to the general female advantage in episodic verbal memory across aging. Thus, it is important to identify methods of examining memory performance that can help to reduce disparities in diagnosis. The serial position effect, a pattern where individuals tend to remember more words at the beginning (primacy) and end (recency) of a list, is predictive of dementia and may provide an avenue for thi

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Kwon, H., S. Lee, S. Oh, S. Kim, and H. Kim. "Phase II study of mFOLFOX-4 followed by mFOLFIRI in advanced gastric cancer." Journal of Clinical Oncology 27, no. 15_suppl (2009): e15546-e15546. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15546.

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e15546 Background: FOLFOX followed by FOLFIRI regimen has been commonly used in colorectal cancer. This combination has also been evaluated in a number of phase II studies in the first- and second-line treatment setting of advanced gastric cancer. We have evaluated the efficacy and toxicity of modified FOLFOX-4 followed by modified FOLFIRI regimens in advanced gastric cancer patients. Methods: Previously untreated patients with advanced or recurrent gastric cancer were enrolled. As first-line therapy, patients received modified FOLFOX-4, bolus ldLV 50mg followed by a 5-FU bolus 400mg/m2 and 22

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Stachenfeld, Nina S., and Hugh S. Taylor. "Effects of estrogen and progesterone administration on extracellular fluid." Journal of Applied Physiology 96, no. 3 (2004): 1011–18. http://dx.doi.org/10.1152/japplphysiol.01032.2003.

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To determine the effect of estrogen and progesterone on plasma volume (PV) and extracellur fluid volume (ECFV), we suppressed endogenous estrogen and progesterone by using the gonadotropin-releasing hormone (GnRH) antagonist ganirelix acetate in seven healthy women (22 ± 1 yr). Subjects were administered GnRH antagonist for 16 days. Beginning on day 5 of GnRH antagonist administration, subjects were administered estrogen (E2) for 11 days, and beginning on day 12 of GnRH antagonist administration, subjects added progesterone (E2-P4) for 4 days. On days 2, 9, and 16 of GnRH antagonist administra

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Durig, James R., Chunhua Pan, Witold Witkowski, and Gamil A. Guirgis. "Conformational stability, infrared and Raman spectra, and vibrational assignment of ethyl bromogermane." Canadian Journal of Chemistry 82, no. 6 (2004): 964–77. http://dx.doi.org/10.1139/v04-048.

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The infrared spectra (320030 cm1) of ethyl bromogermane, CH3CH2GeH2Br, in the gaseous phase and of amorphous and annealed solid samples as well as the Raman spectrum (3200100 cm1) of the liquid have been recorded. Variable-temperature (105 to 150 °C) studies of the infrared spectra of a sample dissolved in liquid krypton have been carried out. From these data, the enthalpy difference between the gauche and trans conformers has been determined to be 158 ± 16 cm1 (1.89 ± 0.20 kJ/mol), with the gauche conformer being the more stable form. This result is consistent with the prediction from

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Friedlander, Anne L., Gretchen A. Casazza, Michael A. Horning, Melvin J. Huie, and George A. Brooks. "Training-induced alterations of glucose flux in men." Journal of Applied Physiology 82, no. 4 (1997): 1360–69. http://dx.doi.org/10.1152/jappl.1997.82.4.1360.

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Friedlander, Anne L., Gretchen A. Casazza, Michael A. Horning, Melvin J. Huie, and George A. Brooks. Training-induced alterations of glucose flux in men. J. Appl. Physiol. 82(4): 1360–1369, 1997.—We examined the hypothesis that glucose flux was directly related to relative exercise intensity both before and after a 10-wk cycle ergometer training program in 19 healthy male subjects. Two pretraining trials [45 and 65% of peak O2 consumption (V˙o 2 peak)] and two posttraining trials (same absolute and relative intensities as 65% pretraining) were performed for 90 min of rest and 1 h of cycling ex

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31

Coggan, Andrew. "Letters to the Editor." Journal of Applied Physiology 84, no. 4 (1998): 1480–82. http://dx.doi.org/10.1152/jappl.1998.84.4.1480.

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The following is the abstract of the article discussed in the subsequent letter: Friedlander, Anne L., Gretchen A. Casazza, Michael A. Horning, Melvin J. Huie, and George A. Brooks. Training-induced alterations of glucose flux in men. J. Appl. Physiol. 82(4): 1360–1369, 1997.—We examined the hypothesis that glucose flux was directly related to relative exercise intensity both before and after a 10-wk cycle ergometer training program in 19 healthy male subjects. Two pretraining trials [45 and 65% of peak O2 consumption (V˙o 2 peak)] and two post- training trials (same absolute and relative inte

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32

Facciorusso, Antonio, Vincenzo Rosario Buccino, Valentina Del Prete, Matteo Antonino, and Nicola Muscatiello. "Cirrhosis Is a Predictor of Adverse Events in Endoscopic Ultrasound Fine-Needle Aspiration: A Propensity-Score Analysis." Digestive Diseases 38, no. 1 (2019): 69–76. http://dx.doi.org/10.1159/000501268.

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Background: Cirrhotic patients are at increased risk of adverse events (AEs) after invasive procedures. However, the safety profile of endoscopic ultrasound (EUS) fine-needle aspiration in cirrhotic patients is still unknown. Objectives: To examine the AEs rate after EUS fine-needle aspiration in cirrhotic patients as compared to a control group of noncirrhotic patients. Methods: Out of 735 patients with suspected abdominal lesions referred to our center between 2006 and 2018, after propensity-score matching, 2 groups were compared: 95 cirrhotics and 95 controls. Primary variables included rat

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Sawattep, Jeeranut, Thad A. Howard, Noppawan P. Morales, et al. "Single Nucleotide Polymorphism (SNP) Discovery within the UGT1A Gene Complex: Allelic Frequencies and Ethnic Differences." Blood 104, no. 11 (2004): 3780. http://dx.doi.org/10.1182/blood.v104.11.3780.3780.

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Abstract The UDP-glycosyltransferase (UGT1A) gene complex plays an important role in the hepatic metabolism of many chemicals, toxins, and drugs including bilirubin and acetaminophen. In this large gene complex that spans over 200kb, there are at least 13 different coding regions that can serve as exon 1, followed by a common sequence that contains exons 2–5. These variable exon 1 sequences confer different chemical specificities for binding compounds, while exons 2–5 provide glycosyltransferase function (glucuronidation) that enhances water solubility and excretion. Mutations and polymorphism

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Karimi, Arash, Hamid Reza Niazkar, Pouria Sefidmooye Azar, et al. "Protective effect of hydro-alcoholic extract of achillea millefolium on renal injury and biochemical factors in streptozotocin-induced diabetic rats." Nutrition & Food Science 51, no. 7 (2021): 1068–83. http://dx.doi.org/10.1108/nfs-11-2020-0437.

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Purpose Herbal medicine has been used for the management of complications of diabetes. The purpose of this paper is to examine the anti-diabetic effects of Achillea millefolium extract on diabetic rats. Design/methodology/approach To this aim, 32 male Wistar rats were randomly assigned into four groups in which each group comprised eight rats. The four experimental groups were as follows: control group, diabetic control (DC) group (STZ; 50 mg/kg), diabetic rats, receiving 250 mg/kg hydro-alcoholic extract of the A. millefolium (DAM) and diabetic rats, receiving 5 mg/kg glibenclamide (DG). Afte

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Giagounidis, Aristoteles, Alan F. List, Eva Hellström-Lindberg, et al. "Prevalence and Impact on Outcomes of Additional Karyotypic Abnormalities in Patients (Pts) with Myelodysplastic Syndromes (MDS) and Del(5q) from the MDS-003 and MDS-004 Studies." Blood 126, no. 23 (2015): 1680. http://dx.doi.org/10.1182/blood.v126.23.1680.1680.

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Abstract Introduction: Approximately 50% of pts with de novoMDS present with cytogenetic abnormalities at diagnosis (Haase D, et al. Ann Hematol. 1995;70:171); deletion (del)5q occurs in ~15% of pts (Haase D, et al. Blood. 2007;110:4385). Cytogenetic abnormalities in addition to del(5q) may be associated with shorter overall survival (OS) and increased risk of progression to acute myeloid leukemia (AML) versus del(5q) alone (Mallo M, et al. Leukemia. 2011;25:110). In 2 large multicenter studies (MDS-003 and MDS-004), lenalidomide (LEN) was evaluated in red blood cell (RBC) transfusion-dependen

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Halpern, Rachel, Victoria Barghout, and Denise Williams. "Compliance with Imatinib Mesylate Associated with Lower Health Resource Utilization and Costs for Patients with CML and GIST." Blood 110, no. 11 (2007): 5159. http://dx.doi.org/10.1182/blood.v110.11.5159.5159.

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Abstract Imatinib mesylate (Gleevec®), has been found both effective and cost-effective for treatment of chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST).This study examines the relationship between compliance and health care utilization and costs. This retrospective study used claims from a large national US health plan. Patients (pts) had ≥2 imatinib claims from 6/1/01–3/31/05; ≥1 yr follow-up (F/U) after the 1st imatinib claim; diagnosis of CML (ICD9 205.1 ×) or GIST (ICD9 159.0, 159.8, 159.9 or evaluation of claims by independent hematologist-oncologist). Compliance

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37

Łosińska, K., M. Wilk, A. H. Pripp, M. Korkosz, and G. Haugeberg. "AB0219 EXPLORING LONG-TERM DRUG EFFECTIVENESS AND DRUG SURVIVAL FOR RITUXIMAB REFERENCE DRUG IN TREATMENT OF RHEUMATOID ARTHRITIS PATIENTS IN ORDINARY OUTPATIENT CLINIC." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1135.3–1136. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1661.

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Background:In randomized controlled trials (RCTs) rituximab (RTX) has been shown to effectively suppress inflammation and reduce structural joint damage in rheumatoid arthritis (RA) patients [1]. There is a lack of RA data on RTX effectiveness and drug survival when used in real life practice.Objectives:To explore long-term drug effectiveness and drug survival for RTX used to treat RA patients in ordinary clinical practice.Methods:The study population included RA patients treated between 2006 and 2020 with RTX at an outpatient clinic in Norway. Patients were monitored using recommended measure

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38

Shishkin, V., G. V. Kudriavtseva, Y. Malenkov, and V. V. Shishkin. "THU0238 ASSOCIATION OF SYSTEMIC DISEASES OF CONNECTIVE TISSUE (SDCT) AND GERONTOLOGICAL PROCESSES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 346.1–346. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1154.

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Background:The approach from the point of view of the evolutionary perspective of finding targets for therapeutic effects among the components of the cellular destruction system is critical both in the treatment of rheumatological diseases and in gerontology.Objectives:To identify the relationships between the pathways of cell death in synovial fluid (SF) of people of different age groups with SDCT.Methods:SF was analyzed in patients of two age groups. Group N 1 of patients: 10 SLE (43±2.3 years), 13 RA (45±1.6 years), 7 SSD (35±1.8 years) and 8 donors (42±2.7 years, postmortem). Group N 2 (ag

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39

Hackney, Madeleine E., Eeshani Singh, Ella Leeth, Allison Bay, and Liang Ni. "MEN WITH PARKINSON'S MAY HAVE GREATER DISEASE BURDEN IN ASPECTS OF COGNITIVE AND PSYCHOSOCIAL FUNCTION THAN WOMEN." Innovation in Aging 3, Supplement_1 (2019): S948—S949. http://dx.doi.org/10.1093/geroni/igz038.3445.

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Abstract Early in PD, women may experience a more benign disease course than man. Limited research has examined differences between men and women with moderate, treated PD with a mean duration &gt;5 y. Retrospective analyses were performed on data collected from studies, conducted 2011–2019, that assessed motor, cognitive and psychosocial function in 199 people with PD (women=72). We compared performance using univariate analyses, adjusting for age, housing type and education. Men and women patients were not different in PD stage (Stage Mdn= 2, IQR=.5), age (mean±SD; 69.1± 8.9 y), educatio

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40

de Rauglaudre, Bernadette, Camille Sibertin-Blanc, Aurélie Fabre, et al. "Predictive value of vascular endothelial growth factor polymorphisms for maintenance bevacizumab efficacy in metastatic colorectal cancer: an ancillary study of the PRODIGE 9 phase III trial." Therapeutic Advances in Medical Oncology 14 (January 2022): 175883592211413. http://dx.doi.org/10.1177/17588359221141307.

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Background: Several studies have reported the impact of single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor ( VEGF) pathway genes on the efficacy of bevacizumab in metastatic colorectal cancer (mCRC), but results are still inconsistent. The PRODIGE 9 phase III study compared bevacizumab maintenance versus observation alone after induction chemotherapy with FOLFIRI plus bevacizumab. Objective: We evaluated the impact of SNPs of VEGF-A, VEGF receptors ( VEGFR-1, VEGFR-2), and hypoxia inducible factor-1α ( HIF-1α) on tumor control duration (TCD), overall survival (OS), pr

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41

Tomelleri, A., C. Campochiaro, G. De Luca, et al. "FRI0506 EFFICACY AND SAFETY OF CANAKINUMAB IN ADULT-ONSET STILL’S DISEASE: A SINGLE-CENTER REAL-LIFE EXPERIENCE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 851.1–852. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2352.

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Background:The pro-inflammatory cytokine interleukin (IL)-1 has a central role in the pathogenesis of adult-onset Still’s disease (AOSD), a rare auto-inflammatory condition. Anakinra, has been for years the cornerstone of IL-1-blocking therapy in AOSD. More recently, the monoclonal antibody canakinumab, a new agent blocking IL-1, has become availableObjectives:To describe our real-life experience with CNK in a cohort of AOSD patients from a single Italian CenterMethods:AOSD patients diagnosed according to Yamaguchi’s criteria followed-up at our Autoinflammatory Unit and treated with CNK for at

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Ahmed, Yasir B., Alzubair M. Ahmed, Abdualmoniem O. Musa, et al. "Clinico-Epidemiology and Molecular Detection of Zika Virus in Kassala, Eastern Sudan." Saudi Journal of Medicine 10, no. 04 (2025): 176–83. https://doi.org/10.36348/sjm.2025.v10i04.006.

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Zika is a disease transmitted to humans by mosquitoes in Africa, Asia, and America, it’s caused by Zika virus (ZIKV) which is a RNA virus, ZIKV is classified within the family Flaviviridae, genus Flavivirus. The monitoring and diagnosis of the viruses early with specific molecular techniques will reduce the severity of viruses. This study aimed to detect the prevalence and molecular detection of ZIKV, and relation of age, sex, locality and other biomarkers to ZIKAV in Kassala State, Eastern Sudan. This was a cross-sectional study conducted in Kassala Teaching Hospital, Kassala State in Eastern

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Nazha, Aziz, Tomas Radivoyevitch, David J. Seastone, et al. "Differences in Genomic Patterns and Clinical Outcomes Between African-American and White Patients with Myelodysplastic Syndromes (MDS)." Blood 124, no. 21 (2014): 3274. http://dx.doi.org/10.1182/blood.v124.21.3274.3274.

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Abstract Background: African-American (AA) patients (pts) have a younger age at diagnosis and worse outcomes compared to whites (WTs) across many cancers, including acute myeloid and lymphoblastic leukemias. This difference may be related to disease biology rather than access to medical care or socioeconomic status. The incidence of MDS and age at diagnosis in national cancer registries in AAs is lower than in WTs. Detailed biological and clinical characteristics and outcome of AA pts with MDS compared to WTs have not been defined. Methods: We collected mutational and clinical data on MDS pts

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Zinsou, Mahougnon, Naivo Naivo RABESIRANANA, Daton MEDENOU, Martin RASOLONIRINA, Bertin Bertin GBAGUIDI, and Guy MENSAH. "Article title: Assessment of natural radioactivity (40K, 238U and 232Th) and radiological risk in building construction materials: the case of Benin hill granites." Brazilian Journal of Radiation Sciences 12, no. 4 (2024): e2530. http://dx.doi.org/10.15392/2319-0612.2024.2530.

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Continuous exposure to ionizing radiation can have harmful effects on human health. In this respect, a study was carried out in the Communes of Dassa-zoume and Glazoue to determine the levels of 40K, 238U and 232Th in granites and sand. The specific activities obtained made it possible to assess the possible radiological risks associated with the resident population. During sampling work in November 2022, twelve granite samples were taken from twelve quarries. In addition, a sand sample was collected in Cotonou for comparison. All samples were then sent to the INSTN-Madagascar laboratory for g

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Elbagir, S., L. M. Diaz-Gallo, G. Grosso, et al. "POS0747 ANTI-PHOSPHATIDYLSERINE/PROTHROMBIN ANTIBODIES AND VASCULAR EVENTS ASSOCIATE POSITIVELY WITH HLA-DRB1*13 AND NEGATIVELY WITH HLA-DRB1*03 IN SLE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 658.2–659. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2243.

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BackgroundAnti-phosphatidylserine/prothrombin antibodies (anti-PS/PT) associate with thrombotic events (1). HLA-DRB1 alleles contribute to the occurrence of conventional antiphospholipid antibodies (aPL), including anti-beta2glycoprotein-I (beta2GPI) and anti-cardiolipin (CL) (2).ObjectivesWe investigated associations between anti-PS/PT and HLA-DRB1 alleles and thrombosis in patients with SLE. Conventional aPL were included for comparison.MethodsWe included 341 consecutive Swedish SLE patients, with information on general cardiovascular risk factors, including blood lipids, lupus anticoagulant

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Shen, Jessica, Naritsara Wongtong, Denis Noubouossie, et al. "Lack of Difference in Hepcidin Levels in Sickle Cell Anemia and Sickle Cell Beta Thalassemia." Blood 126, no. 23 (2015): 4591. http://dx.doi.org/10.1182/blood.v126.23.4591.4591.

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Abstract Introduction: Sickle cell disease (SCD) may be associated with iron overload following repeated RBC transfusions. In beta thalassemia major, a disease characterized by hemolysis and ineffective erythropoiesis, iron overload occurs due to both repeated RBC transfusions and hyperabsorption of iron. Hyperabsorption of iron occurs due to ineffective erythropoiesis and subsequent downregulation of hepcidin, the main regulator of systemic iron homeostasis. With the presence of a thalassemia gene, HbSβ-thalassemia patients may have an increased tendency to hyperabsorb iron compared to HbSS p

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McAnally, Brooke E., Dallas R. Soffa, Molly S. Smith, et al. "PSI-12 Characterization of Boar Reproductive Tract Microbiome Prior to Puberty Attainment." Journal of Animal Science 101, Supplement_3 (2023): 365–66. http://dx.doi.org/10.1093/jas/skad281.434.

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Abstract A large portion of microbiome research has focused on characterization of the gastrointestinal tract and female reproductive tract. However, minimal research has focused on establishing the bacterial community in other organs, specifically male reproductive tissues and gonads. Characterization of these microbiomes in early life could be an indicator of future semen microbiome composition and subsequent fertility status. The aim of this study was to characterize the bacterial communities of various male reproductive tissues including the testes, epididymis, seminal vesicles, prostate,

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Vitovskiy, R., O. Bolshak, V. Boukarim, Yu Bakhovska, and V. Popov. "Mitral Valve Plasty During Correction of Combined Mitral-Aortic Valve Diseases." Ukrainian journal of cardiovascular surgery, no. 4 (41) (December 16, 2020): 63–68. http://dx.doi.org/10.30702/ujcvs/20.4112/059063-068/407-08-097.

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The aim. To study reconstructive operations on the mitral valve (MV) combined with aortic valve replacement (AVR) for combined mitral-aortic valve defects (CMAVD). Materials and methods. The study included 1690 patients with CMAVD who underwent surgical treatment at the National Amosov Institute of Cardiovascular Surgery of the National Academy of Medical Sciences of Ukraine for the period from 01/01/2006 to 01/01/2020. Of these, 429 (23.4%) patients underwent MV reconstruction with AVR. The following valve-sparing procedures were performed: – application of annuloplasty ring: 123

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Gattermann, Norbert, Mathias Schmid, Matteo Della Porta, et al. "Efficacy and Safety of Deferasirox (Exjade®) during 1 Year of Treatment in Transfusion-Dependent Patients with Myelodysplastic Syndromes: Results from EPIC Trial." Blood 112, no. 11 (2008): 633. http://dx.doi.org/10.1182/blood.v112.11.633.633.

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Abstract Background: Many patients (pts) with myelodysplastic syndromes (MDS) [particularly those with Low- or Int-1-risk] are susceptible to iron overload from ongoing blood transfusions and increased dietary iron absorption. Deferasirox (Exjade®) has shown efficacy in maintaining or reducing body iron (assessed by liver iron concentration [LIC] and serum ferritin [SF]) in MDS pts. More recently, the efficacy and safety of deferasirox in pts with various underlying anemias, including MDS, was evaluated in the large EPIC study. Data for MDS pts are presented here. Methods: The EPIC study was a

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van Vollenhoven, R., T. Takeuchi, J. Aelion, et al. "POS0655 LONG-TERM SAFETY AND EFFICACY OF UPADACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS: 3-YEAR RESULTS FROM THE SELECT-EARLY STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 568–69. http://dx.doi.org/10.1136/annrheumdis-2021-eular.530.

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Background:Upadacitinib (UPA), an oral Janus kinase inhibitor, demonstrated significant improvements in signs, symptoms, and structural inhibition as monotherapy (mono) vs methotrexate (MTX) in MTX-naïve patients (pts) with rheumatoid arthritis (RA) through 48 weeks (wks).1Objectives:To report the efficacy and safety of UPA vs MTX mono up to 156 wks in pts with RA from the ongoing long-term extension (LTE) of the SELECT-EARLY trial.Methods:During the 48-wk double-blind study period, pts were randomized to UPA 15 or 30 mg once daily (QD) or MTX (titrated to 20 mg/wk by Wk 8). At Wk 26, pts who

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