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Добірка наукової літератури з теми "343.148 (477)(043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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Статті в журналах з теми "343.148 (477)(043.2)"

Yousuf, Muhammad, Ayalew Tefferi, Naseema Gangat, et al. "Hydroxyurea vs. hypomethylating vs. other agents in chronic myelomonocytic leukemia: A retrospective inspection of treatment strategies among 457 Mayo Clinic patients." Journal of Clinical Oncology 43, no. 16_suppl (2025): 6579. https://doi.org/10.1200/jco.2025.43.16_suppl.6579.

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6579 Background: Treatment strategies in chronic myelomonocytic leukemia (CMML) are not standardized and include hydroxyurea (HU) and hypomethylating agents (HMA). In a phase 3 study comparing HU and decitabine, in proliferative CMML, response rates were higher for decitabine (56% vs 31%; p<0.01) but overall survival was similar (p=0.67) between the two groups (Itzykson, R. JCO, 2023. 41:1888). In the current retrospective study, we examined the survival impact of different treatment strategies among 457 Mayo Clinic patients with CMML. Methods: The current study was conducted under institut

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Dombret, Hervé, Alexandra Coelho, Laurène Fenwarth, et al. "Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study." Blood 144, Supplement 1 (2024): 2424. https://doi.org/10.1182/blood-2024-207226.

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Introduction. AML treatment options have been recently enriched. New agents like gemtuzumab ozogamicin (GO), FLT3 or IDH inhibitors, or CPX-351 have been approved for some patient subsets. Less-intensive options, like the AZA-VEN combination, are used in older/unfit patients. However, while treatments and indications are standardized, their choice is not, depending on often-subjective factors. This makes observational studies so important to describe the real-life management and outcomes of AML patients. Methods. In 2022, the ALFA group initiated a 2-cohort (newly diagnosed, relapsed/refractor

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Liao, Wei, Matthew Paul Smeltzer, Jordan Goss, et al. "Lung cancer diagnosis rates (LCDR) in lung cancer screening (LCS) and incidental pulmonary nodule (IPN) cohorts in the Mississippi Delta." Journal of Clinical Oncology 43, no. 16_suppl (2025): 8002. https://doi.org/10.1200/jco.2025.43.16_suppl.8002.

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8002 Background: The LCDR in the CT screened cohort in the National Lung Screening Trial (NLST) was 1.1% over a median of 6.5 years follow up. We evaluated the LCDR in a regional US community. Methods: Prospective cohort study of patients in LCS and IPN programs in 22 facilities across a 125 county service area population. We compared LCDR over 3 years in LCS stratified by Lung-RADS (L-R) score (1 to 4X), IPN by nodule size (≤6, >6-15, >15-20, >20-30 mm) on initial CT scans. Comparisons used Chi-square tests, Wilcoxon tests, and Cox regression models with Hazard Ratios (HR) for lung c

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Musso Ribeiro de Oliveira Souza, Chiara, Gustavo Ribeiro Lima, and Angélica Espinosa Miranda. "Blood-borne infections and pregnancies among women attending a sexual violence assistance center in Brazil: A 10-year retrospective study." PLOS ONE 18, no. 2 (2023): e0280419. http://dx.doi.org/10.1371/journal.pone.0280419.

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Introduction Sexually transmitted infections (STI) and pregnancy can be consequences of sexual violence. In Brazil, around 50% of women victims of sexual violence do not undergo STI prophylaxis or emergency contraception. Objectives To analyze socio-demographic and epidemiological profile, frequency of procedures performed, frequency of blood-borne infections (BBI), pregnancy, and legal abortion in women assisted by a sexual violence assistance center. Patients and methods This 10-year retrospective cohort study (2010–2019) describes the socio-demographic and epidemiological profile and freque

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Teshima, Takanori, K. Matsuo, K. Matsue, et al. "Impact of HLA Mismatch on the Incidence of Acute GVHD and Rejection after Reduced-Intensity Conditioning Hematopoietic Stem Cell Transplantation (RICT)." Blood 104, no. 11 (2004): 2758. http://dx.doi.org/10.1182/blood.v104.11.2758.2758.

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Abstract HLA incompatibility between the donor and recipient is the most critical factor governing the incidence of rejection and GVHD after conventional allogeneic stem cell transplantation. But the impact of HLA disparity on GVHD and graft rejection after RICT remains to be elucidated. We retrospectively analyzed the outcomes of 437 patients who underwent bone marrow (n=95) or peripheral blood stem cell RICT (n=342). The numbers of patients who received a graft from a HLA-matched (275 from siblings, 11 from family members, and 54 from unrelated donors), one-locus-mismatched, 2- or 3-loci-mis

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Tan, Juanyi, Szu-Chun Yang, Michaela A. Dinan, Anne C. Chiang, Cary P. Gross, and Shi-Yi Wang. "Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer." JAMA Network Open 8, no. 6 (2025): e2514519. https://doi.org/10.1001/jamanetworkopen.2025.14519.

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ImportanceTargeted therapies and immunotherapies prolong survival but are associated with high costs for patients with advanced non–small cell lung cancer (aNSCLC). To date, little is known about survival and medication cost by biomarker status in the US.ObjectiveTo estimate survival and medication cost by aNSCLC biomarker status.Design, Setting, and ParticipantsThis retrospective cohort study using Flatiron Health data identified patients diagnosed with aNSCLC from January 1, 2016, through December 31, 2022. Each patient had received at least 1 biomarker test and 1 documented line of therapy;

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Radchenko, Elena V., Olga A. Sykhovskaya, Timofey L. Galankin, Aleksei S. Kolbin, and Maria A. Smirnova. "Network meta-analysis: a comparison of effectiveness and safety of partial agonists of nicotinic acetylcholine receptors varenicline and cytisine for smoking cessation." Reviews on Clinical Pharmacology and Drug Therapy 16, no. 4 (2018): 19–32. http://dx.doi.org/10.17816/rcf16419-32.

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Background. Partial agonists of α4b2 nicotinic acetylcholine receptors are the most effective treatment strategy for tobacco smoking cessation. They are able to alleviate withdrawal symptoms and to reduce smoking satisfaction. The aim of this study was to review the efficacy and safety of nicotinic receptor partial agonists varenicline and cytisine, for smoking cessation. Methods. A search for randomized controlled trials was done using the terms (“cytisine”, “tabex”, “varenicline” or 'partial agonists of nicotinic receptors’) in MEDLINE, EMBASE, eLibrary in May 2018. Types of part

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Biswas, Sourav, Zeba Khanam, Asraful Alam, and Lakshminarayan Satpati. "Progress and determinants of household access to improved drinking water in India using a Water Access Index: insights from the National Family Health Survey towards achieving SDG 6.1." BMJ Open 15, no. 6 (2025): e091269. https://doi.org/10.1136/bmjopen-2024-091269.

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Background and objectiveAccess to clean drinking water is essential for health and development. Despite global and national initiatives, many regions in India continue to face inadequate water access. This study assesses progress, sociodemographic determinants and geographic disparities in access to drinking water in India, aligning with Sustainable Development Goal (SDG) 6.1.DesignThis study used secondary data from five rounds of the National Family Health Survey (NFHS-1 to NFHS-5; 1992–2021), nationally representative surveys conducted across India. Logistic regression was employed to exami

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Vadhan-Raj, Saroj, Naomi V. Dahl, Kristine Bernard, Zhu Li, and William Strauss. "Efficacy and Safety of IV Ferumoxytol (FER) for Iron Deficiency Anemia (IDA) in Patients with Cancer." Blood 124, no. 21 (2014): 1352. http://dx.doi.org/10.1182/blood.v124.21.1352.1352.

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Abstract Background: IDA is common in cancer patients due to blood loss and inflammation. Many do not tolerate oral iron or adequately respond. Two Phase-3 trials investigated the efficacy and safety of IV FER for treatment of IDA in patients with a history of unsatisfactory oral iron therapy or in whom oral iron could not be used. This analysis explored the impact of IV iron treatment on the subgroup of patients with cancer. Methods: Data from patients with cancer were extracted from 2 RCTs (NCT01114139; NCT01114204) in which patients with baseline (BL) Hgb 7-10g/dL, TSAT <20%, were random

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Zhong, Runbo, Min Yan, Qiming Wang, et al. "Phase 1 trial of SHR-A2102, a nectin-4–directed antibody drug conjugate (ADC), in advanced solid tumors." Journal of Clinical Oncology 43, no. 16_suppl (2025): 107. https://doi.org/10.1200/jco.2025.43.16_suppl.107.

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107 Background: Nectin-4 is a cell adhesion molecule that is highly expressed in a wide variety of cancers and is associated with poor prognosis. SHR-A2102 is a novel ADC consisting of a fully humanized Nectin-4–directed monoclonal antibody, bound to topoisomerase I inhibitor payload via a cleavable linker. We conducted a multi-center, phase 1 trial to evaluate SHR-A2102 in advanced solid tumors. Methods: Patients (pts) with Nectin-4 positive, locally advanced unresectable or metastatic solid tumors were enrolled. The study included dose-escalation (D-ESC), dose-expansion (D-EXP) and efficacy-

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Тези доповідей конференцій з теми "343.148 (477)(043.2)"

Демидова, Т. Ю., К. Г. Лобанова та А. С. Кочина. "КЛИНИЧЕСКИЕ И ЛАБОРАТОРНЫЕ ОСОБЕННОСТИ ПАЦИЕНТОВ С САХАРНЫМ ДИАБЕТОМ 2 ТИПА, ГОСПИТАЛИЗИРОВАННЫХ В ЦЕНТР СПАСЕНИЯ КОНЕЧНОСТЕЙ В 2019-2020 ГГ." У X (XXIX) НАЦИОНАЛЬНЫЙ КОНГРЕСС ЭНДОКРИНОЛОГОВ с международным участием «Персонализированная медицина и практическое здравоохранение». ФГБУ «НМИЦ эндокринологии» Минздрава России, 2023. http://dx.doi.org/10.14341/cong23-26.05.23-100.

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Поражение нижних конечностей (НК) при сахарном диабете (СД) является частой причиной ампутации, что приводит к значительному снижению качества жизни пациентов. Несмотря на широкий спектр совре- менных методов лечения СД, прогрессивный рост количества ампутаций у данных пациентов является актуальной проблемой. ЦЕЛЬ: изучить клинико-лабораторные характеристики пациентов центра спасения конечностей (ЦСК) с сахарным диабетом 2 типа (СД2). МАТЕРИАЛЫ И МЕТОДЫ: проведен ретроспективный анализ 729 историй болезни пациентов, имею- щих СД2 и госпитализированных

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