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Статті в журналах з теми "343.783 (043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

De Paepe, Katja, Lawrence Bonne, Nicos Fotiadis, et al. "Complications and seeding risk after percutaneous liver biopsy in an oncological setting." Journal of Clinical Oncology 36, no. 4_suppl (2018): 246. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.246.

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246 Background: Percutaneous biopsy of suspected liver metastases is a common practice for diagnostic purposes. Particularly, in the setting of oncological clinical trials, it is a relatively non-invasive method to obtain sufficient tissue for molecular analyses at regular set time points. However, various complications may occur, including seeding of the tumour along the biopsy tract. Only few reports exist on the actual incidence of seeding, on a limited number of tumor types. The aim of this study was to evaluate the technique’s safety and risk of seeding. Methods: All patients with an ultr

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2

Rahmawati, Fitria Hasanuddin Hasanuddin, Muhammad Purqan Nur, Hijriah S. Samudra, and Nurlinda Maiyo Maiyo. "Deteksi Dini Diabetes Mellitus Tipe 2 Terhadap Kegawatdaruratan Hiperglikemia Dan Hipoglikemia Melalui Screening GDS." Jurnal Kesehatan 17, no. 2 (2024): 130–37. http://dx.doi.org/10.32763/xntdd078.

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tar Belakang: IDF melaporkan prevalensi diabetes secara global sebanyak 537 juta pada tahun 2021, diperkirakan akan meningkat menjadi 643 juta pada tahun 2030 dan 783 juta pada tahun 2045. Angka kematian di atas 6,7 juta pada tahun 2021, 1 kematian setiap 5 detik. Indonesia menempati urutan kelima dengan 19,5 juta pada tahun 2021. Lebih dari 90% menderita T2D akibat faktor sosial ekonomi, demografi, lingkungan, dan genetik. Kegawatdaruratan hipoglikemia dan hiperglikemia dapat menyebabkan Ketoasidosis Diabetikum dan Status Hiperosmolar Hiperglikemi yang mengancam jiwa, sehingga perlu deteksi d

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3

Yee, Timothy Joseph, Cheerag D. Upadhyaya, Domagoj Coric, et al. "288 Impact of Disc Degeneration on Clinical Outcomes After Fusion for Grade 1 Spondylolisthesis: A 5-year QOD Study." Neurosurgery 70, Supplement_1 (2024): 82. http://dx.doi.org/10.1227/neu.0000000000002809_288.

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INTRODUCTION: Disc degeneration with loss of disc height can be an indication to fuse patients with lumbar spondylosis. However, its relevance for spondylolisthesis is unknown. METHODS: The Quality Outcomes Database was queried for adult patients who underwent fusion for single-level degenerative grade 1 lumbar spondylolisthesis. Pfirrmann grade at the level to be fused was assessed on preoperative sagittal T2-weighted MRI. VAS-back pain (BP-VAS), VAS-leg pain (LP-VAS), and ODI were collected preoperatively and at 3, 12, 24, 36, and 60 months postoperatively. RESULTS: The query returned 395 pa

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4

Раимкулов, К. М., В. С. Тойгомбаева, О. Т. Куттубаев та А. Э. Мергенов. "КЫРГЫЗ РЕСПУБЛИКАСЫНЫН ОШ ОБЛУСУНУН КАЛКЫНЫН АРАСЫНДА ЭХИНОКОККОЗ ООРУЛАРЫ МЕНЕН ЖАБЫРКАШЫНА ЖАНА ЖҮРҮМ-ТУРУМ ТОБОКЕЛДИК ФАКТОРЛОРУНА БАА БЕРҮҮ". Euroasian Health Journal, № 1 (29 березня 2024): 137–45. http://dx.doi.org/10.54890/ehj-2024-1-137.

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В статье рассмотрены результаты ультразвукового исследования (УЗИ), иммуноферментного анализа (ИФА), исследования на наличие специфических антител, результаты опроса населения 7 районов (8823 человек) и оценки поведенческого фактора риска заражения эхинококкозами населения Ошской области Кыргызской Республики (КР). По результатам ИФА получено 12,0 ± 0,3% (1060) положительных, на УЗИ 8,0 ±0,4% (703). Чаще выявлялась инвазия альвеококкозом как на УЗИ, так на ИФА – 334 (3,78%) и 74,3 ± 0,4% (788) соответственно. Самым эндемичным районом оказался Алайский, где инвазированность обследованных лиц со

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5

Kwon, Min-Cheol, and Il-Ho Kim. "Preparation and Thermoelectric Properties of Si-Doped Tetrahedrites Cu12Sb4-ySiyS13." Korean Journal of Metals and Materials 60, no. 6 (2022): 440–47. http://dx.doi.org/10.3365/kjmm.2022.60.6.440.

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Si-doped Cu12Sb4-ySiyS13 (y = 0.1-0.4) compounds were prepared using solid-state synthesis. Each specimen consisted of a single tetrahedrite phase with a densely sintered body whose relative density exceeded 98.9%. The lattice constant decreased from 1.0357 nm to 1.0336 nm as the Si content increased. When the Si doping content (y) exceeded 0.3, the decrease in the lattice constant was reduced and residual Si appeared. This established the solubility limit of Si at the Sb sites was y = 0.3. The Seebeck coefficient increased with the temperature and Si content, achieving a maximum value of 178

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6

Davies, M. A., A. Y. Bedikian, S. McIntyre, et al. "Natural history of metastatic melanoma patients with CNS metastases." Journal of Clinical Oncology 24, no. 18_suppl (2006): 8054. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.8054.

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8054 Background: Melanoma has a high rate of CNS metastasis (mets). The objective of this study was to evaluate the characteristics and outcomes of melanoma patients (pts) who develop CNS mets. Methods: 333 pts with a diagnosis of CNS mets were identified from databases of 743 chemotherapy naïve metastatic melanoma (MM) pts enrolled on clinical trials between 1986 and 2004. Their clinical and pathological characteristics were reviewed. Results: The site of primary melanoma was head or neck (60/333; 18%), trunk/abdomen (144/333; 43%), limbs (66/333; 20%), ocular (2/333; 1%), or unknown (61/333;

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7

Kearon, Clive, Jeffrey J. Ginsberg, Jim Julian, et al. "Fixed-Dose, Weight-Adjusted, Unfractionated Heparin (UFH) Given Subcutaneously (sc) without Laboratory Monitoring for Acute Treatment of Venous Thromboembolism (VTE): Randomized Comparison with Low-Molecular-Weight-Heparin (LMWH)." Blood 104, no. 11 (2004): 707. http://dx.doi.org/10.1182/blood.v104.11.707.707.

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Abstract Background: Treatment of VTE with UFH is usually by intravenous (iv) infusion with adjustment of dose in response to the activated partial thromboplastin time (APTT). However, (1) there is no evidence that adjusting UFH in response to APTT results reduces recurrent VTE or bleeding if patients are receiving an appropriate dose of UFH, and (2) sc UFH might be preferable to iv UFH. We hypothesized that UFH is as effective and safe as LMWH when each is administered sc in weight-adjusted, fixed-doses. Methods: We performed a multicentre, randomized, open-label, trial that compared fixed-do

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8

Peres, Marco Antonio de Oliveira, Tâmara Maria Nieri, Heitor Sebastião de Barcelos Neto, and Nelson Adami Andreollo. "A técnica de Lichtenstein nas hérnias inguinais primárias e recidivadas - cirurgia ambulatorial em hospital universitário." ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) 20, no. 4 (2007): 221–24. http://dx.doi.org/10.1590/s0102-67202007000400001.

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RACIONAL: A técnica de Lichtenstein é o padrão-ouro na cirurgia das hérnias inguinais, permitindo fixação de prótese de polipropileno, sem tensão na linha de sutura, baixa recidiva, ampla aplicabilidade, fácil ensino aos jovens cirurgiões, alta precoce e menores custos. OBJETIVO: Análise retrospectiva dos resultados na cirurgia ambulatorial das hérnias inguinais primárias e recidivas pela técnica de Lichtenstein em Hospital Universitário. MÉTODOS: Entre agosto de 1994 a dezembro de 2001 foram realizadas 343 hernioplastias inguinais em 326 portadores de hérnias inguinais primárias ou recidivada

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9

Durán, Josefina, Loreto Massardo, Carolina Llanos, et al. "The Prevalence of Rheumatoid Arthritis in Chile: A Nationwide Study Performed as Part of the National Health Survey." Journal of Rheumatology 47, no. 7 (2019): 951–58. http://dx.doi.org/10.3899/jrheum.190396.

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Objective.Genetic and environmental backgrounds influence the development of rheumatoid arthritis (RA). In Latin America, epidemiologic data are scarce. We aimed to determine the prevalence of RA in Chile in a population-based study.Methods.The National Health Survey was a cross-sectional household survey with a stratified multistage probability sample of 6233 participants performed between August 2016 and March 2017. A screening instrument for RA was applied to a random sample of 3847 subjects > 30 years old. Positive screening was defined by at least 1 of the following: 2 swollen joints f

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10

Killgore, William, Vincent Capaldi, Michael Grandner, and Gary Kamimori. "786 Trait Extraversion is Associated with Increased Suicidal Ideation During Total Sleep Deprivation and Insomnia." Sleep 44, Supplement_2 (2021): A306—A307. http://dx.doi.org/10.1093/sleep/zsab072.783.

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Abstract Introduction It is known that sleep disturbance is associated with increased suicidal thinking, and completed suicides are most common during the late night/early morning hours, but no studies have examined the role of trait-like individual differences in vulnerability to suicidal ideation during sleep deprivation or insomnia. In two separate studies, we examined whether the trait of extraversion is predictive of changes in suicidal thinking following two nights of sleep deprivation and among individuals meeting criteria for insomnia. Methods Study 1: Twenty-five healthy military pers

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11

Tellez, Hayver Olaya, Silvia Capuani, Fernando Ferrari Putti, and Roberto Lyra Villas Bôas. "VARIÁVEIS BIOMÉTRICAS E PÓS-COLHEITA DA ALFACE HIDROPÔNICA TRATADA COM PULSOS ELÉTRICOS DE BAIXA FREQUÊNCIA." IRRIGA 28, no. 2 (2023): 331–47. http://dx.doi.org/10.15809/irriga.2023v28n2p331-347.

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VARIÁVEIS BIOMÉTRICAS E PÓS-COLHEITA DA ALFACE HIDROPÔNICA TRATADA COM PULSOS ELÉTRICOS DE BAIXA FREQUÊNCIA HAYVER OLAYA TELLEZ1; SILVIA CAPUANI2; CAMILA PAULA ROSSETTO PESCATORI JACON3; FERNANDO FERRARI PUTTI4 E ROBERTO LYRA VILLAS BÔAS5 Parte da tese de doutorado do primeiro autor, apresentada ao Programa de Pós-graduação em Irrigação e Drenagem, Universidade Estadual Paulista, Campus Botucatu, Botucatu SP, Brasil. 1 Departamento de Engenharia Rural, Faculdade de Ciências Agronômicas, Universidade Estadual Paulista (UNESP), Avenida Universitária, nº 3780 –CEP 18610-034. Altos do Paraíso, Bot

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12

Abu-Freha, Naim, Rachel Gouldner, Bracha Cohen, et al. "Comorbidities and Risk Factors of Patients Diagnosed with CRC after Positive Fecal Test in Real Life." Cancers 14, no. 22 (2022): 5557. http://dx.doi.org/10.3390/cancers14225557.

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(1) Background: Fecal occult blood test (FOBT) is the modality of choice in most countries for colorectal cancer (CRC) screening. We aimed to investigate the risk factors for CRC among patients with a positive FOBT in real life. (2) Methods: This was a retrospective study that included patients who tested positive for FOBT. Data regarding the comorbidities and laboratories were collected and compared between CRC and non-CRC groups. (3) Results: Positive FOBT was found among 45,500 (5.36%) subjects and CRC was found in 1502 (3.3%). CRC patients were older, age 62.7 ± 7.15 years compared with 59

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13

Chubarova, N. Y., A. A. Poliukhov, and I. D. Gorlova. "Long-term variability of aerosol optical thickness in Eastern Europe over 2001–2014 according to the measurements at the Moscow MSU MO AERONET site with additional cloud and NO<sub>2</sub> correction." Atmospheric Measurement Techniques Discussions 8, no. 7 (2015): 7843–78. http://dx.doi.org/10.5194/amtd-8-7843-2015.

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Abstract. The aerosol properties of the atmosphere were obtained within the framework of the AERONET program at the Moscow State University Meteorological Observatory (Moscow MSU MO) over 2001–2014 period. The quality data control has revealed the necessity of their additional cloud and NO2 correction. The application of cloud correction according to hourly visual cloud observations provides a decrease in average aerosol optical thickness (AOT) at 500 nm of up to 0.03 compared with the standard dataset. We also show that the additional NO2 correction of the AERONET data is needed in large mega

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14

Geist, David R. "Hyporheic discharge of river water into fall chinook salmon (Oncorhynchus tshawytscha) spawning areas in the Hanford Reach, Columbia River." Canadian Journal of Fisheries and Aquatic Sciences 57, no. 8 (2000): 1647–56. http://dx.doi.org/10.1139/f00-102.

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Fall chinook salmon (Oncorhynchus tshawytscha) spawned predominantly in areas of the Hanford Reach of the Columbia River where hyporheic water discharged into the river channel. This upwelling water had a dissolved solids content (i.e., specific conductance) indicative of river water and was presumed to have entered highly permeable riverbed substrate at locations upstream of the spawning areas. Hyporheic discharge zones composed of undiluted ground water or areas with little or no upwelling were not used by spawning salmon. Rates of upwelling into spawning areas averaged 1200 L·m-2·day-1 (95%

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15

Sayegh, Nicolas, Yeonjung Jo, Zeynep Irem Ozay, et al. "Survival outcomes of patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) receiving lutetium-177-PSMA-617 (Lu) based on line of therapy." Journal of Clinical Oncology 43, no. 5_suppl (2025): 82. https://doi.org/10.1200/jco.2025.43.5_suppl.82.

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82 Background: Lu is a prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical that delivers beta radiation to PSMA-positive cells. It is approved for pts with mCRPC who had prior progression on an androgen receptor pathway inhibitor (ARPI) and taxane-based chemotherapy. However, there are limited real-world data on the efficacy of Lu based on the line of therapy. Herein, we aimed to assess the survival outcomes of pts with mCRPC receiving Lu in a real-world setting. Methods: This retrospective study utilized the nationwide Flatiron Health electronic health record (EHR) derived

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16

Coelho, Claudia, Rachel Agius, James Crane, and Barbara McGowan. "Pharmacotherapy for weight loss in adults with type 2 diabetes: a systematic review of randomised controlled trials." British Journal of Diabetes 21, no. 1 (2021): 20–29. http://dx.doi.org/10.15277/bjd.2021.281.

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Background: Clinically significant weight loss improves glycaemic control and cardiovascular disease risk in patients with type 2 diabetes (T2DM).Aim: To identify and assess the efficacy of medical treatments for weight loss in adults with T2DM.Methods: A systematic review was conducted of peer- reviewed literature between July 2004 and July 2020 via PubMed, Embase, Web of Science, medRxiv and Cochrane Central Register of Controlled Trials. Randomised controlled trials (RCTs) in English investigating medical treatments for weight loss in patients with T2DM were included. RCTs of pharmacotherap

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17

Yandag, Munkhdelger, Altansukh Tsend-Ayush, Nyamaa Gunregjav, et al. "Detection and antibiotic resistance of diarrheagenic Escherichia coli from patients with diarrhea in Ulaanbaatar, Mongolia." Journal of Infection in Developing Countries 17, no. 02 (2023): 202–9. http://dx.doi.org/10.3855/jidc.17256.

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Introduction: Diarrheal diseases are common with worldwide distribution, and diarrheagenic Escherichia coli (DEC) strains are the main causative agents. The present study aimed to define the association of various pathotypes of E. coli from diarrheal patients in Mongolia. Methodology: A total of 341 E. coli strains were isolated from the stool of diarrheal patients. Bacterial susceptibility to antimicrobial agents was determined by the Kirby Bauer disk diffusion method. DEC isolates were identified by HEp-2 cell adherence assay and multiplex polymerase chain reaction (PCR). Results: DEC pathog

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18

Dobbie, Laurence J., Daniel J. Cuthbertson, Theresa J. Hydes, Uazman Alam, and Sizheng Steven Zhao. "Mendelian randomisation reveals Sodium-glucose Cotransporter-1 inhibition's potential in reducing Non-Alcoholic Fatty Liver Disease risk." European Journal of Endocrinology 188, no. 6 (2023): K33—K37. http://dx.doi.org/10.1093/ejendo/lvad068.

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Abstract Non-alcoholic fatty liver disease (NAFLD) has no approved pharmacological treatments. Sodium-glucose cotransporter (SGLT)-1 is a glucose transporter that mediates small intestinal glucose absorption. We evaluated the impact of genetically proxied SGLT-1 inhibition (SGLT-1i) on serum liver transaminases and NAFLD risk. We used a missense variant, rs17683430, in the SLC5A1 gene (encoding SGLT1) associated with HbA1c in a genome-wide association study (n = 344 182) to proxy SGLT-1i. Outcome genetic data comprised 1483 NAFLD cases and 17 781 controls. Genetically proxied SGLT-1i was assoc

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19

Gabbay, Itay Elimelech, Felicity Allen, Christine Morley, Tahmina Pearsall, Oliver Martyn Bowes, and Simon Ruben. "Efficacy and safety data for the XEN45 implant at 2 years: a retrospective analysis." British Journal of Ophthalmology 104, no. 8 (2019): 1125–30. http://dx.doi.org/10.1136/bjophthalmol-2019-313870.

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AimTo report efficacy and safety measures for XEN45 in a National Health Service setting after 24-month follow-up.MethodsThis is a retrospective, non-comparative audit of records of patients who underwent XEN45 procedure between June 2015 and May 2017. The main outcome measures were intraocular pressure (IOP) reduction and number of antihypertensive medications at each timepoint. Failure was defined as requiring further surgery or removal of XEN. Success was defined as 20% reduction of IOP without additional glaucoma medications or reduction in antihypertensive medications without increase in

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20

Friedel, B. A., and R. J. Hudson. "Productivity of farmed wapiti in Alberta." Canadian Journal of Animal Science 74, no. 2 (1994): 297–303. http://dx.doi.org/10.4141/cjas94-041.

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Calving and weaning rates of 1084 wapiti hinds (females) were collected in the 1990 season by an on-farm survey of 50 producers in Alberta, to determine the reproductive performance of farmed wapiti. A calving rate of 81 and 96% for 2-yr-old and adult hinds, respectively, gave a provincial herd average of 93%. Weaning rates of 73% for 2-yr-old and 91% for adult hinds resulted in an 88% weaning rate overall. One set of triplets and three sets of twins gave a multiple birth ratio of one in 271 calvings. Overall calf mortality was 5.2% in the survey, with a trend (P = 0.07) for 2-yr olds to exper

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21

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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22

O'Reilly, Eileen M., Teresa Macarulla, Laetitia Dahan, et al. "Evaluating the relative treatment efficacy of CD40 agonist mitazalimab in combination with mFOLFIRINOX in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) using unanchored indirect treatment comparisons (ITCs)." Journal of Clinical Oncology 43, no. 4_suppl (2025): 723. https://doi.org/10.1200/jco.2025.43.4_suppl.723.

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723 Background: Mitazalimab, a human CD40 agonistic IgG1antibody has demonstrated encouraging results in combination with mFOLFIRINOX (mFFX) in the phase 2 single arm trial OPTIMIZE-1 in patients with mPDAC. We conducted unanchored ITCs to assess the relative efficacy of mitazalimab + mFFX vs FOLFIRINOX (FFX) / mFFX and NALIRIFOX (NFX), the most effective therapies to date. Methods: Using data from OPTIMIZE-1 and published data from five RCTs identified via a literature review, matching-adjusted indirect comparisons (MAIC) and simulated treatment comparisons (STC), two commonly used ITC method

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Gaccioli, Francesca, Katie Stephens, Ulla Sovio, et al. "Placental Streptococcus agalactiae DNA is associated with neonatal unit admission and foetal pro-inflammatory cytokines in term infants." Nature Microbiology 8, no. 12 (2023): 2338–48. http://dx.doi.org/10.1038/s41564-023-01528-2.

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AbstractStreptococcus agalactiae (Group B Streptococcus; GBS) is a common cause of sepsis in neonates. Previous work detected GBS DNA in the placenta in ~5% of women before the onset of labour, but the clinical significance of this finding is unknown. Here we re-analysed this dataset as a case control study of neonatal unit (NNU) admission. Of 436 infants born at term (≥37 weeks of gestation), 7/30 with placental GBS and 34/406 without placental GBS were admitted to the NNU (odds ratio (OR) 3.3, 95% confidence interval (CI) 1.3–7.8). We then performed a validation study using non-overlapping s

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24

Bellmunt, Joaquim, Ronald De Wit, David J. Vaughn, et al. "Two-year follow-up from the phase 3 KEYNOTE-045 trial of pembrolizumab (pembro) vs investigator’s choice (paclitaxel, docetaxel, or vinflunine) in recurrent, advanced urothelial cancer (UC)." Journal of Clinical Oncology 36, no. 6_suppl (2018): 410. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.410.

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410 Background: Based on interim results from the phase 3 KEYNOTE-045 (NCT02256436) study comparing pembro v investigator’s choice of chemotherapy (chemo), pembro was approved for the treatment of locally advanced or metastatic UC that has progressed during or after a platinum-containing regimen. Updated results after 2 years of follow-up are presented. Methods: Eligible patients (histologically or cytologically confirmed UC, progression after platinum, ECOG PS 0-2, measurable disease per RECIST v1.1, ≤2 lines of systemic therapy) were randomly assigned 1:1 to pembro 200 mg Q3W or investigator

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Louhanepessy, Rebecca, Sushil Badrising, Vincent van der Noort, et al. "Clinical outcomes of a Dutch prospective observational registry of metastatic castration resistant prostate cancer (mCRPC) patients treated with radium-223 (Ra-223)." Journal of Clinical Oncology 37, no. 7_suppl (2019): 323. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.323.

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323 Background: In 2012 the ALSYMPCA study established a 3.6 month Overall Survival (OS) benefit of mCRPC patients treated with Ra-223 over placebo. To date clinical outcomes of Ra-223 treatment in a non-study population have not been prospectively evaluated. Methods: The ROTOR registry aimed to include 300 patients in 20 Dutch hospitals prior to Ra-223 treatment at the physician’s discretion. Clinical parameters collected included: positioning of Ra-223, Adverse Events (AE’s; CTCAE v4.03), Skeletal Related Events (SRE) and survival data. SRE was defined as radiotherapy to a bone metastasis, a

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Coenen, Eva A., Susana C. Raimondi, Jochen Harbott, et al. "Clinical Impact of Additional Cytogenetic Aberrations and Complex Karyotype In Pediatric 11q23/MLL-Rearranged AML: Results from an International Retrospective Study." Blood 116, no. 21 (2010): 762. http://dx.doi.org/10.1182/blood.v116.21.762.762.

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Abstract Abstract 762 Pediatric AML is a heterogeneous disease. We showed that differential outcomes of 11q23/MLL-rearranged AML depend on the fusion partner involved in the translocation in a large international retrospective study from 11 collaborative groups comprising 756 children (Balgobind et al, Blood 2009). In the current analysis we focused on the clinical characteristics and prognostic impact of additional cytogenetic aberrations (ACA). All patients with complete karyotypes (n=733) were centrally reviewed and classified for type and number of aberrations. Cases with 2 or more aberrat

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Arivoli, Subramanian, Miriam Vassou, Samuel Tennyson, Athikesavan Ramanan, Selvaraj Divya, and Pac Kamatchi. "Analysis of Soil and Water Quality in Selected Villages of Ranipet District, Tamil Nadu, India." Current World Environment 16, no. 2 (2021): 477–91. http://dx.doi.org/10.12944/cwe.16.2.14.

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Quality of soil and water are determined by measuring the concentration of their parameters and comparing them with standards. In the present study, soil samples (top, sub and inner) from three zones, zone 1 (industrial area), zone 2 (10km from industrial area) and zone 3 (agricultural land/fields) of Puliyanthangal village, and the bore well, well and pond water samples of Kathiyavadi village were analysed from January 2019 to December 2019. Soil texture was sandy loam in all the zones. The pooled values for pH, electrical conductivity (dS/m), organic carbon (%), available nitrogen, phosphoro

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Powell, Danielle, Wuyang Zhang, and Nicholas Reed. "EFFECT OF AWARENESS OF HEARING LOSS AMONG CARE RECIPIENTS ON ATTRIBUTES OF CARE PROVIDED: A NATIONAL STUDY." Innovation in Aging 8, Supplement_1 (2024): 778. https://doi.org/10.1093/geroni/igae098.2529.

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Abstract Hearing loss (HL) is prevalent among older adults and may result in caregiving challenges due to communication barriers. This study aims to investigate whether care recipients’ awareness of HL is associated with attributes of care. Using data from Round 12 (2022) of the linked National Health and Aging Trends Study (NHATS) and National Study on Caregiving (NSOC), a sample of 1,133 (Mean age: 62±15 years; Female: 68%) caregivers assisting 713 older adults (Mean age: 83±8 years; Female: 63%; White: 63%) with audiometric HL was derived. From care recipients’ self-reported hearing difficu

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De Jonghe, Bart C., Andras Hajnal, and Mihai Covasa. "Increased oral and decreased intestinal sensitivity to sucrose in obese, prediabetic CCK-A receptor-deficient OLETF rats." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 1 (2005): R292—R300. http://dx.doi.org/10.1152/ajpregu.00481.2004.

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CCK-A receptor-deficient Otsuka Long-Evans Tokushima fatty (OLETF) rats are hyperphagic and develop obesity and Type 2 diabetes. In this strain, taste preference functions have not been investigated. Therefore, a series of short-access, two-bottle tests were performed in age-matched prediabetic OLETF and nonmutant Long-Evans Tokushima Otsuka (LETO) rats to investigate preference for sucrose (0.03, 0.1, 0.3, or 1.0 M) presented with a choice of water. To discern orosensory from postgastric factors that may contribute to this preference, in a separate experiment, rats were allowed to sham feed s

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Fernandez, Adrian N., Kevin D. Li, Hiren V. Patel, et al. "Injuries With Electric vs Conventional Scooters and Bicycles." JAMA Network Open 7, no. 7 (2024): e2424131. http://dx.doi.org/10.1001/jamanetworkopen.2024.24131.

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ImportanceMicromobility, the use of small vehicles (primarily scooters and bicycles), has become a standard transportation method in the US. Despite broad adoption of electric micromobility vehicles, there is a paucity of data regarding the injury profiles of these vehicles, particularly in the US.ObjectiveTo characterize micromobility injury trends in the US, identify demographic characteristic differences in users of electric and conventional vehicles, and identify factors associated with hospitalization.Design, Setting, and ParticipantsThis cross-sectional study queried the National Electro

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Matei, Daniela, Virginia L. Filiaci, Marcus Randall, et al. "A randomized phase III trial of cisplatin and tumor volume directed irradiation followed by carboplatin and paclitaxel vs. carboplatin and paclitaxel for optimally debulked, advanced endometrial carcinoma." Journal of Clinical Oncology 35, no. 15_suppl (2017): 5505. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.5505.

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5505 Background: Patients with stage III/IVA uterine cancer (UC) carry high risk of systemic and local recurrence. Chemotherapy was shown to reduce systemic recurrence, however the risk of local failure remains high. Methods: The primary endpoint of this open label, randomized phase III trial was to determine if treatment with cisplatin and volume-directed radiation followed by carboplatin and paclitaxel for 4 cycles (C-RT, experimental arm) reduces the rate of recurrence or death (i.e., increases recurrence-free survival, RFS) when compared to carboplatin and paclitaxel for 6 cycles (CT, cont

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Graue, Marit, Jannicke Igland, Anne Haugstvedt, et al. "Evaluation of an interprofessional follow-up intervention among people with type 2 diabetes in primary care—A randomized controlled trial with embedded qualitative interviews." PLOS ONE 18, no. 11 (2023): e0291255. http://dx.doi.org/10.1371/journal.pone.0291255.

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With an ageing population and improved treatments people live longer with their chronic diseases, and primary care clinics face more costly and difficult-to-treat multimorbid patients. To meet these challenges, current guidelines for the management of type 2 diabetes suggest that an interprofessional team should collaborate to enhance the delivery of worthwhile self-management support interventions. In this study, we aimed to evaluate the effects of an empowerment-based interprofessional follow-up intervention in people with type 2 diabetes in primary care on patient-reported outcomes, biomark

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Wada, Eri, Takeshi Onoue, Tomoko Kobayashi, et al. "Flash glucose monitoring helps achieve better glycemic control than conventional self-monitoring of blood glucose in non-insulin-treated type 2 diabetes: a randomized controlled trial." BMJ Open Diabetes Research & Care 8, no. 1 (2020): e001115. http://dx.doi.org/10.1136/bmjdrc-2019-001115.

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IntroductionThe present study aimed to evaluate the effects of flash glucose monitoring (FGM) and conventional self-monitoring of blood glucose (SMBG) on glycemic control in patients with non-insulin-treated type 2 diabetes.Research design and methodsIn this 24-week, multicenter, open-label, randomized (1:1), parallel-group study, patients with non-insulin-treated type 2 diabetes at five hospitals in Japan were randomly assigned to the FGM (n=49) or SMBG (n=51) groups and were provided each device for 12 weeks. The primary outcome was change in glycated hemoglobin (HbA1c) level, and was compar

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Lofters, W. S., J. L. Pater, B. Zee, et al. "Phase III double-blind comparison of dolasetron mesylate and ondansetron and an evaluation of the additive role of dexamethasone in the prevention of acute and delayed nausea and vomiting due to moderately emetogenic chemotherapy." Journal of Clinical Oncology 15, no. 8 (1997): 2966–73. http://dx.doi.org/10.1200/jco.1997.15.8.2966.

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PURPOSE To compare the efficacy of dolasetron and ondansetron in controlling nausea and vomiting in the first 24 hours; to evaluate the efficacy when dexamethasone is added to either drug in the first 24 hours; and to extend these comparisons over 7 days in patients receiving moderately emetogenic chemotherapy. PATIENTS AND METHODS This was a multicenter, double-blind, randomized study with six parallel arms that used a 2 x 2 factorial design in chemotherapy-naive patients. In arm 1, dolasetron (2.4 mg/kg) was given intravenously (I.V.) prechemotherapy, followed 24 hours later by oral dolasetr

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Austin, Publishing Group. "The Role of Calcium in Augmenting the Efficacy of Primary Homeostasis after Hemorrhagic Shock." Annals of Hematology & Oncology 10, no. 1 (2023): 1415. https://doi.org/10.26420/annhematoloncol.2023.1415.

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Abstract <strong>Background:</strong> Traumatic Hemorrhagic Shock (THS) causes hypocalcemia (Ca). This study assesses how low Ca affects platelet (Plt) function. <strong>Study Design:</strong> A research registry was queried for 555 studies on 341 patients (pts) with THS requiring 14.2 units RBC, 8.4 units FFP, 3.6 units Plt, and 18.9 mEq Ca by end of O.R. (7.3 hours). Factors analyzed included Plt count, Ca, Bleeding Time (BT), Plt aggregation with ADP (PAadp) and collagen (PAcol), including Max PA, T1/2 PA, and rate PA, plus platelet release factors, beta thromboglobulin (BTG) and

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Armocida, Benedetta, Giulia Zamagni, Elena Magni, et al. "Clinical, anamnestic, and sociodemographic predictors of positive SARS-CoV-2 testing in children: A cross sectional study in a tertiary hospital in Italy." PLOS ONE 17, no. 1 (2022): e0262923. http://dx.doi.org/10.1371/journal.pone.0262923.

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Objectives We aimed to identify clinical, anamnestic, and sociodemographic characteristics associated with a positive swab for SARS-CoV2, and to provide a predictive score to identify at risk population in children aged 2–14 years attending school and tested for clinical symptoms of COVID-19. Design Cross sectional study. Setting Outpatient clinic of the IRCCS Burlo Garofolo, a maternal and child health tertiary care hospital and research centre in Italy. Data collection and analysis Data were collected through a predefined form, filled out by parents, and gathered information on sociodemograp

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Xie, Wen, Hong Zhao, Yu Chen, et al. "A Retrospective, Multi-Center, Post-Marketing Observational Study to Evaluate the Effectiveness of Ademetionine 1,4-Butanedisulfonate Injection (Transmetil®) Treatment in Chinese Patients with Intrahepatic Cholestasis Caused by Viral Hepatitis." Infection International 2, no. 2 (2013): 71–80. http://dx.doi.org/10.1515/ii-2017-0043.

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Abstract Obejective Ademetionine 1,4-butanedisulfonate [S-adenosyl-L-methionine (SAMe)/Transmetil®, Abbott] has been available in China for more than 15 years, and it has been shown to reduce serum bilirubin and transaminase levels in viral hepatitis (VH) patients. However, no large-scale studies have focused on the impact of SAMe treatment regimen on reducing the serum total bilirubin (TBil) in VH patients with intrahepatic cholestasis (IHC). The primary purpose of this study was to evaluate the effectiveness of intravenous SAMe (Transmetil®) treatment in reducing the serum TBil by 50%. Metho

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Kitridis, Dimitrios, Ioannis Tsifountoudis, Dimitrios Georgiannos, Konstantinos Tsikopoulos, Panagiotis Givissis, and Ilias Bisbinas. "Does Bone Regrow After Notchplasty in ACL Reconstruction? A Prospective Computed Tomography Study With 2-Year Follow-up." Orthopaedic Journal of Sports Medicine 9, no. 9 (2021): 232596712110292. http://dx.doi.org/10.1177/23259671211029228.

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Background: During notchplasty in anterior cruciate ligament (ACL) reconstruction, bone is excised from the lateral and roof area of the notch to widen the intercondylar space and avoid notch-graft impingement in extension. There are concerns that bone regrowth of the area will cause narrowing and increase the risk of complications. Purpose: To determine the possibility of late narrowing of the notch after notchplasty using computed tomography (CT) analysis. Study Design: Case series; Level of evidence, 4. Methods: Measurements were performed on CT scans (axial and sagittal planes with knee in

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Castrejon, I., J. Molina Collada, C. Perez-Garcia, et al. "POS1439 CANCER IN PATIENTS WITH RHEUMATIC DISEASES EXPOSED TO DIFFERENT BIOLOGIC AND TARGETED SYNTHETIC DMARDS IN REAL-WORLD CLINICAL PRACTICE: DATA FROM A MULTICENTER REGISTER." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1063. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3834.

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BackgroundExtensive evidence has confirmed no increased risk of cancer associated to either conventional synthetic DMARDs or anti-TNF in patients with rheumatic diseases. The risk of cancer in biologic (bDMARDs) different to anti-TNF and targeted synthetic (tsDMARDs) is considerably less investigated. As new therapies are emerging, more data in real-world registries are needed to confirm safety in other treatment groups.ObjectivesTo compare the risk of cancer of tsDMARDs and other bDMARDs versus anti-TNF in patients with rheumatic diseases.MethodsData of patients enrolled in BIOBADASER 3.0 up

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Heukelom, Jolien, Arash Navran, Zeno A. R. Gouw, et al. "Organ Function Preservation Failure after (Chemo)Radiotherapy in Head and Neck Cancer: A Retrospective Cohort Analysis." Otolaryngology–Head and Neck Surgery 161, no. 2 (2019): 288–96. http://dx.doi.org/10.1177/0194599819846073.

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Objective The aim of the current study was to determine the incidence of organ function preservation failure (OFPF) in patients with head and neck squamous cell carcinoma (HNSCC) treated by (chemo)radiotherapy and to identify its risk factors. Study Design Retrospective cohort analysis. Setting Tertiary cancer care center. Subjects and Methods A single-center retrospective cohort analysis was done (n = 703) in which OFPF after (chemo)radiotherapy was assessed. OFPF was defined as local failure or pure functional failure in the absence of local failure because of major surgical intervention (to

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Chen, Yanfang, Luis F. Joaquim, Vera M. Farah, et al. "Cardiovascular autonomic control in mice lacking angiotensin AT1a receptors." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 288, no. 4 (2005): R1071—R1077. http://dx.doi.org/10.1152/ajpregu.00231.2004.

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Studies examined the role of angiotensin (ANG) AT1a receptors in cardiovascular autonomic control by measuring arterial pressure (AP) and heart rate (HR) variability and the effect of autonomic blockade in mice lacking AT1a receptors (AT1a −/−). Using radiotelemetry in conscious AT1a +/+ and AT1a −/− mice, we determined 1) AP and pulse interval (PI) variability in time and frequency (spectral analysis) domains, 2) AP response to α1-adrenergic and ganglionic blockade, and 3) intrinsic HR after ganglionic blockade. Pulsatile AP was recorded (5 kHz) for measurement of AP and PI and respective var

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Yusuf, Bustanil, Kabul Budiman, and Nursalam Nursalam. "ANALYSIS OF FARMING NILAM (POGOSTEMON CABLIN BENTH) AT TOARI DISTRICT OF KOLAKA." Agribusiness Journal 1, no. 2 (2016): 33–41. http://dx.doi.org/10.31327/aj.v1i2.155.

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This research aims to; 1) determine the factors that affect the production of patchouli production, 2) determine the allocative efficiency of production factors patchouli farming, 3) determine the scale of business, 4) To determine the financial feasibility of farming patchouli. The sample in this study is a research location patchouli farmers totaling 50 respondents. Data were analyzed using Cobb-Douglass, Statistics Test Analysis, analysis of allocative efficiency, scale of operations and financial feasibility. This study shows that: 1) The results of the analysis test F known that simultane

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Jain, Sarika, and Tulsi Das Chugh. "Antimicrobial resistance among blood culture isolates of Salmonella enterica in New Delhi." Journal of Infection in Developing Countries 7, no. 11 (2013): 788–95. http://dx.doi.org/10.3855/jidc.3030.

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Introduction: Enteric fever is a global public health problem, especially in developing countries. Antimicrobial resistance is a major issue enteric fever management. This study examined current pattern of antimicrobial susceptibility among Salmonella enterica isolates from enteric fever cases at a tertiary care centre in New Delhi, India. Methodology: Blood cultures from patients with enteric fever during January 2010- July 2012 were processed using the BACTEC automated system. Antimicrobial susceptibility was tested using Kirby Bauer’s disc diffusion method and/or Phoenix 100 automated syste

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Bijaylaxmi, Mohanty, Behera J., Mohanty P., Acharya S., K. Patnaik A., and P. Das S. "Kinetics and mechanism of oxidation of L-cysteine and DL-methionine by morpholinium chlorochromate in aqueous acidic medium." Journal of Indian Chemical Society Vol. 88, Oct 2011 (2011): 1561–66. https://doi.org/10.5281/zenodo.5790631.

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P.G. Department of Chemistry, Utkal University, Bhubaneswar-751 004, Orissa, India IMMT, Bhubaneswar, Orissa, India P.G. Department of Chemistry, Khallikote (Autonomous) College, Berhampur-760 001, Orissa, India <em>E-mail</em> : ajaypattanaik_kumar@yahoo.co.in P.G. Department of Chemistry, Ravenshaw University, Cuttack-753 003, Orissa, India <em>Manuscript received 25 November 2010, revised 09 March 2011, accepted 17 March 2011</em> The kinetics of the redox reaction of MCC (morpholinium chlorochromate) with L-cysteine and DL-methionine have been studied over the range 2.0 ≤ 10<sup>3</sup>

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Deschênes, Isabelle, Carolyn Finkle, and Peter Winocour. "Effective Use of BCH-2763, a New Potent Injectable Direct Thrombin Inhibitor, in Combination with Tissue Plasminogen Activator (tPA) in a Rat Arterial Thrombolysis Model." Thrombosis and Haemostasis 80, no. 07 (1998): 186–91. http://dx.doi.org/10.1055/s-0037-1615161.

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SummaryCurrent therapeutic use of heparin as an adjunct to thrombolytic therapy for myocardial infarction is suboptimal with respect to efficacy and bleeding risk. In a rat carotid arterial thrombolysis model (FeCl3-induced injury) we evaluated the combined effect of tPA (2.0 mg/kg/ 30 min) with our potent injectable direct thrombin inhibitor, BCH-2763 (Ki 0.11 nM; MW 1.5 kDa), which, unlike heparin, inhibits bound and free thrombin; comparisons were with standard heparin (SH), other direct thrombin inhibitors, r-hirudin (MW 6.5 kDa) and hirulog (MW 2.3 kDa), or tPA alone. Time to lysis (TL),

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Patel, Anuj Bharatkumar, Vicky Mai, Lucia Caiano, et al. "Fatal Pulmonary Embolism, Fatal Bleeding and Intracranial Hemorrhage with Systemic and Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism: A Systematic Review with Meta-Analysis." Blood 142, Supplement 1 (2023): 2644. http://dx.doi.org/10.1182/blood-2023-182859.

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Background: Thrombolysis, either systemic (ST) or catheter-directed (CDT), may reduce mortality in patients with intermediate-high and high-risk pulmonary embolism (PE), but with an increased risk of major bleeding (MB). Moreover, uncertainties remain for other efficacy and safety outcomes, such as fatal PE, fatal bleeding, and intracranial hemorrhage (ICH). Aims: To evaluate fatal PE, fatal bleeding and ICH with ST and CDT in patients with intermediate-high and high-risk PE. Methods: We performed a systematic search in MEDLINE, EMBASE and Cochrane from inception to December 2022. Randomized t

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Molina Centeno, Julio Cesar, Sergio Cuadra, Mauricio Guzmán, Noel Duarte, and Aurelio Llano. "ADAPTACIÓN Y RENDIMIENTO DE LA VARIEDAD DE FRIJOL INTA VAINA ROJA, PARA TOLERANCIA A SEQUÍA Y MANCHA ANGULAR EN CUATRO REGIONES DE NICARAGUA." La Calera 13, no. 20 (2014): 24–30. http://dx.doi.org/10.5377/calera.v13i20.1621.

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El presente trabajo se llevó a cabo entre los años 2005 y 2007, con el objetivo de evaluar la adaptación y rendimiento de la variedad mejorada INTA Vaina Roja, en las zonas de Las Segovias, Centro Norte, Centro Sur y Pacífico Sur de Nicaragua. En el año 2006 se condujeron nueve ensayos de rendimiento, uno en Madriz, cinco en Estelí, uno en Matagalpa y dos en Jinotega. En las etapas preliminares de rendimiento, el ensayo incluyó 51 líneas F8, y en las pruebas avanzadas de rendimiento se incluyeron 34 líneas F9 y 14 líneas F8 y F9. Estos trabajos se realizaron de acuerdo a las condiciones agroec

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Chamseddine, Sarah, Haniah A. Zaheer, John V. Williams, Judith M. Martin, Anne-Marie Rick, and Hui Liu. "1328. Risk Factors for Severe Influenza Outcomes Among Infants Born Between 2011 and 2019." Open Forum Infectious Diseases 8, Supplement_1 (2021): S752. http://dx.doi.org/10.1093/ofid/ofab466.1520.

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Abstract Background Influenza in infancy can cause significant morbidity and mortality. This study aimed to characterize influenza outcomes in infants &lt; ορ = 12 months and identify risk factors for severe infection. Methods A retrospective cohort of infants ≤ 12 months born between 2011-2019 who received longitudinal ambulatory and inpatient care within a multi-facility hospital system and had laboratory-confirmed influenza were included. Perinatal, medical and illness characteristics were described. Risk factors for severe influenza (hospitalization, intensive-care unit (ICU) admission

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Yu, Svena, Ning Zhang, Matthew D. L. Garayt, Kate Leslie, Chongyin Yang, and Jeff R. Dahn. "All Dry in One Step (ADIOS to Water) Synthesis of W-Coated Li_1+X(Ni_0.7Mn_0.3)_1-XO₂." ECS Meeting Abstracts MA2023-02, no. 2 (2023): 263. http://dx.doi.org/10.1149/ma2023-022263mtgabs.

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Cathode powders for lithium-ion batteries are typically made from hydroxide precursors with the intended transition metal composition and calcined with a lithium source at high temperatures to make LiMO2, where M = Ni, Mn, Co. However, large amounts of process water and salts like NaOH are used in the co-precipitation process employed to make these hydroxide precursors1. Purifying and drying the precursors after co-precipitation requires additional energy input and produces waste streams that are difficult to treat, as illustrated in Fig. 1a. In this work, we introduce a simple, solvent-free m

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