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Статті в журналах з теми "347.625 (043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Maziasz, P. J., J. P. Shingledecker, N. D. Evans, et al. "Creep Strength and Microstructure of AL20-25+Nb Alloy Sheets and Foils for Advanced Microturbine Recuperators." Journal of Engineering for Gas Turbines and Power 129, no. 3 (2006): 798–805. http://dx.doi.org/10.1115/1.2718569.

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The Oak Ridge National Laboratory (ORNL) and ATI Allegheny Ludlum worked together on a collaborative program for about two years to produce a wide range of commercial sheets and foils of the new AL20-25+Nb™ (AL20–25+Nb) stainless alloy for advanced microturbine recuperator applications. There is a need for cost-effective sheets/foils with more performance and reliability at 650–750°C than 347 stainless steel, particularly for larger 200–250 kW microturbines. Phase 1 of this collaborative program produced the sheets and foils needed for manufacturing brazed plated-fin air cells, while Phase 2 p

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2

Rimer, Ernest G., Linda R. Peterson, Andrew R. Coggan, and James C. Martin. "Increase in Maximal Cycling Power With Acute Dietary Nitrate Supplementation." International Journal of Sports Physiology and Performance 11, no. 6 (2016): 715–20. http://dx.doi.org/10.1123/ijspp.2015-0533.

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Muscle-shortening velocity and hence power have been shown to increase in the presence of nitric oxide (NO). NO availability increases after consuming nitrate (NO3-). Ingestion of NO3-rich beetroot juice (BRJ) has increased muscle power in untrained adults.Purpose:This study determined whether NO3- supplementation could acutely enhance maximal power in trained athletes.Methods:In this double-blind, crossover study, 13 trained athletes performed maximal inertial-load cycling trials (3–4 s) immediately before (PRE) and after (POST) consuming either NO3-rich (NO3) or NO3-depleted (PLA) BRJ to ass

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3

Kaur, Palakdeep, Max Cowan, Joanne De Faveri, Mobashwer Alam, and Bruce Topp. "Evaluating Self-Pollination Methods: Their Impact on Nut Set and Nutlet Abscission in Macadamia." Plants 13, no. 24 (2024): 3456. https://doi.org/10.3390/plants13243456.

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Nut set is an important determinant of yield and plays a pivotal role in orchard profitability. The complex process of nut setting is governed by numerous factors, with pollination being a critical mechanism. Macadamia cultivars exhibit both self- and cross-pollination. Self-pollination may increase nut set, so it is a trait of interest in breeding. This study investigated nut setting and nutlet abscission on four cultivars, ‘HAES 791’, ‘HAES 741’, ‘HAES 344’, and ‘A16’, using three controlled self-pollination methods: (i) autogamy (AG), entailing bagging before anthesis with no hand-pollinati

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4

Alpizar-Rodriguez, D., F. Irazoque-Palazuelos, T. S. Rodriguez-Reyne, et al. "POS1242 FACTORS ASSOCIATED WITH MORTALITY IN PATIENTS WITH RHEUMATIC DISEASES AND COVID-19 IN MEXICO." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 904.1–904. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3342.

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Background:As of the 25th of January 2021, more than 150 thousand deaths as consequence of COVID-19 have been reported in Mexico [1]. Advanced age, male gender and comorbidities have been described as risk factors for severe disease and mortality in general population [2]. COVID-19 mortality in Mexican patients with rheumatic and musculoskeletal diseases (RMDs) is unknown.Objectives:To describe characteristics of Mexican patients with RMDs and COVID-19, and to analyse factors associated with mortality.Methods:The Global Rheumatology Alliance COVID-19 (GRA) physician reported registry, is an in

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5

Ferrari, Federica, Fortunata Civitelli, Francesca Ardenti Morini, et al. "The Use of Antigenic SARS-CoV-2 Point-of-Care Test: The Italian Pediatric Real-Life Experience." Clinical Pediatrics 61, no. 1 (2021): 34–41. http://dx.doi.org/10.1177/00099228211053916.

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In Italy, during the second epidemic wave of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rapid antigenic (Ag) test at point-of-care (POCT) station were employed to quickly evaluate large numbers of swabs. We collected data of all children who underwent the Ag test in our hospital. All positive patients were recalled to perform reverse transcription polymerase chain reaction. A total of 2133 tests were collected over 1 month. Clinical data of 1941 children (median age = 3.7 years) were analyzed: 1343 (69.2%) patients complained of symptoms, 594 (30.6%) had a history of close c

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6

Álvarez-Reguera, C., J. J. Gaitán-Valdizán, R. Fernández-Ramón, et al. "POS0740 EPIDEMIOLOGY AND CLINICAL FEATURES OF OCULAR SARCOIDOSIS. STUDY OF 65 PATIENTS OF A SERIES OF 384 PATIENTS FROM A SINGLE UNIVERSITY HOSPITAL." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 621.2–622. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1930.

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Background:Ocular involvement in sarcoidosis can be present in up to 80% of patients. If not treated, it can lead to significant visually complications (1-5).Objectives:Our aim was to assess the main a) epidemiology and b) clinical features of ocular sarcoidosis in a wide and unselected series from a single university hospital.Methods:Study of a large cohort (n=384) of all consecutive patients diagnosed with sarcoidosis from January 1, 1999 to December 31, 2019. Finally, 344 patients were included according to the ATS/ERS/WASOG criteria (Eur Respir J. 1999;14:735-7).Results:65 (33 men/32 women

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7

Ostorga, Antonio Dono, Gabriella Hines, Soheil Zorofchian Moghadamtous, Yoshua Esquenazi, and Leomar Y. Ballester. "OTHR-06. ANALYSIS OF GENOMIC ALTERATIONS IN 154 BRAIN METASTASES." Neuro-Oncology Advances 1, Supplement_1 (2019): i19. http://dx.doi.org/10.1093/noajnl/vdz014.083.

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Abstract Brain Metastases (BM) are associated with poor prognosis. Understanding the genomic alterations (GA) that drive tumor metastasis to the brain will increase our ability to identify patients at risk for BM, and provide better opportunities to implement targeted therapies. We performed a retrospective review of genomic alterations in 154 patients with BM from various primary sites (80 Lung, 22 Breast, 16 Melanoma, 5 Kidney, 4 Colorectal, 4 Prostate, and 23 carcinomas from unknown primary (UP). All cases were analyzed by a next generation sequencing assay the detects mutations in the codi

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8

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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9

Kim, Johnny S., Becci A. Akin, and Jody Brook. "Solution-focused brief therapy to improve child well-being and family functioning outcomes with substance using parents in the child welfare system." Developmental Child Welfare 1, no. 2 (2019): 124–42. http://dx.doi.org/10.1177/2516103219829479.

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This study examined the effectiveness of solution-focused brief therapy (SFBT) on child well-being and family functioning outcomes for child welfare involved parents. A randomized controlled trial design was used to evaluate the effectiveness of SFBT as compared to treatment-as-usual in an outpatient substance abuse treatment center. Mixed linear models tested within and between-group changes using intent-to-treat analysis ( N = 180). Hedges’s g effect sizes examined the magnitude of treatment effects. Both conditions reported improvements on the child well-being measures (Behavior Rating Inve

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10

Brinkworth, Grant D., Thomas P. Wycherley, Pennie J. Taylor, and Campbell H. Thompson. "A Health Care Professional Delivered Low Carbohydrate Diet Program Reduces Body Weight, Haemoglobin A1c, Diabetes Medication Use and Cardiovascular Risk Markers—A Single-Arm Intervention Analysis." Nutrients 14, no. 20 (2022): 4406. http://dx.doi.org/10.3390/nu14204406.

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This study examined the effectiveness of a health care professional delivered low-carbohydrate diet program (Diversa Health Program) aiming to improve obesity/type-2-diabetes management for people living in Australia. 511 adults (Age:57.1 ± 13.7 [SD] yrs) who participated between January 2017–August 2021 for ≥30 days with pre-post data collected for ≥1 key outcome variable (body weight and HbA1c) were included in the analysis. Average participation duration was 218 ± 207 days with 5.4 ± 3.9 reported consultation visits. Body weight reduced from 92.3 ± 23.0 to 86.3 ± 21.1 kg (n = 506, p < 0.

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11

Fernández Molinari, Luis, and Guillermo Aguilar V. "Tipos de pelvis en la mujer peruana. Estudio radiopelvimétrico." Revista Peruana de Ginecología y Obstetricia 19, no. 1 (2015): 11–13. http://dx.doi.org/10.31403/rpgo.v19i781.

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De un estudio de 320 radiopelvimetrías, entre los años 1963 a 1968, sacamos las siguientes conclusiones: 1 .-Las pelvis más comunmente encontradas, fueron las Ginecoides, que dieron el total de 47.2% . De ellas, la Ginecoide pura aportó e l 24.4%, la Ginecoide-Androide el 9.7 %, la Ginecoide-Platipeloide el 6.85% y finalmente la Ginecoide-Antropoide el 6.25 %. 2.- Las pelvis Platipeloide ocuparon en orden decreciente, el segundo lugar, con un porcentaje de 40.95. De ellas la Platipelo-Ginecoide resultó el 18.75%, la Platipeloide-pura el 17.2%, la Platipelo-Androide e l 3.7% y la PIatipelo-Antr

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12

Sartorio, A., M. Jubeau, F. Agosti, et al. "GH responses to two consecutive bouts of neuromuscular electrical stimulation in healthy adults." European Journal of Endocrinology 158, no. 3 (2008): 311–16. http://dx.doi.org/10.1530/eje-07-0775.

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BackgroundIt is well established that repeated GHRH administration or repeated voluntary exercise bouts are associated with a complete blunting of GH responsiveness when the administration of the second stimulus follows the first one after a 2-h interval.AimTo evaluate GH responses to neuromuscular electrical stimulation (NMES) in healthy adults.MethodsSix volunteers (mean age±s.d. 31.7±5.5 years) were studied before and after two consecutive bouts of NMES exercise (a series of 20 contractions at the maximum of individual tolerance, frequency: 75 Hz, pulse duration: 400 μs, on–off ratio: 6.25–

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13

Bertuccio, Giuseppe, S. Caccia, Filippo Nava, et al. "Ultra Low Noise Epitaxial 4H-SiC X-Ray Detectors." Materials Science Forum 615-617 (March 2009): 845–48. http://dx.doi.org/10.4028/www.scientific.net/msf.615-617.845.

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The design and the experimental results of some prototypes of SiC X-ray detectors are presented. The devices have been manufactured on a 2’’ 4H-SiC wafer with 115 m thick undoped high purity epitaxial layer, which constitutes the detection’s active volume. Pad and pixel detectors based on Ni-Schottky junctions have been tested. The residual doping of the epi-layer was found to be extremely low, 3.7 x 1013 cm-3, allowing to achieve the highest detection efficiency and the lower specific capacitance of the detectors. At +22°C and in operating bias condition, the reverse current densities of the

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14

M, Woh Wei, and Chee Keong S. "HYPERGLYCAEMIC EMERGENCY ADMISSION, POST-DISCHARGE CARE AND 6-MONTHS OUTCOME IN HOSPITAL BENTONG." Journal of the ASEAN Federation of Endocrine Societies 34 (July 17, 2019): 20–21. https://doi.org/10.15605/jafes.034.s28.

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INTRODUCTIONDiabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) are two acute complications of diabetes with increased morbidity and mortality if not treated appropriately. Outcome and follow-up care of patients after recovery and discharge for DKA/HHS is relatively under-reported and unknown. The aim of this study was to assess DKA and HHS admission and postdischarge care and outcome. METHODOLOGYThis is a cross-sectional study including all patients with DKA and HHS admitted to Hospital Bentong from January 2017 to December 2018. Clinical records were reviewed for demograph

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15

Chu, Michelle, Mimi Lou, Mengxi Wang, and Allison Flores. "A Real-world Study Evaluating the Clinical Factors Associated with the Initial SGLT2 Inhibitor Prescription." Journal of Health Care for the Poor and Underserved 35, no. 3 (2024): 866–79. http://dx.doi.org/10.1353/hpu.2024.a934303.

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Abstract: The American Diabetes Association (ADA) guidelines prioritize Sodicum-glucose transporter-2-inhibitors (SGLT2i) given cardio-renal and glycemic benefits. This study was conducted to observe clinical factors associated with initial SGLT2i prescription in type 2 diabetes patients eligible for SGLT2i by the ADA. Methods. A retrospective case-control study was performed in a safety-net clinic and consisted of the initial SGLT2i prescriptions group and the group without. The data from the electronic medical records between July 2021 and December 2022 were analyzed in the regressional mode

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16

Parkington, Jascha D., Nathan K. LeBrasseur, Adam P. Siebert, and Roger A. Fielding. "Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle." Journal of Applied Physiology 97, no. 1 (2004): 243–48. http://dx.doi.org/10.1152/japplphysiol.01383.2003.

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With age, skeletal muscle experiences substantial atrophy and weakness. Although resistance training can increase muscle size and strength, the myogenic response to exercise and the capacity for muscle hypertrophy in older humans and animals is limited. In the present study, we assessed the ability of muscle contractile activity to activate cellular pathways involved in muscle cell growth and myogenesis in adult (Y; 6 mo old) and aged (O; 30 mo old) Fischer 344 × Brown Norway rats. A single bout of rat hindlimb muscle contractile activity was elicited by high-frequency electrical stimulation (

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17

Álvarez-Reguera, C., J. J. Gaitán-Valdizán, R. Fernández-Ramón, et al. "OP0091 TREATMENT OF OCULAR SARCOIDOSIS. STUDY OF 65 PATIENTS OF A SERIES OF 384 PATIENTS FROM A SINGLE UNIVERSITY HOSPITAL." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 50.1–50. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1896.

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Background:Ocular involvement is a relatively frequent and potentially severe complication of sarcoidosis. Oral corticosteroids (OCS) are the first-line treatment. Conventional immunosuppressive agents (cIS) and biological therapy (BT) can be used in refractory cases (1-5).Objectives:To evaluate the treatment and visual outcomes of a cohort of patients diagnosed with ocular sarcoidosis.Methods:Study of a large cohort (n=384) of all consecutive patients diagnosed with sarcoidosis from January 1, 1999 to December 31, 2019 at a single University Hospital. Finally, 344 patients were included accor

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18

Walz, Lars, Gian M. Salzmann, Thomas Fabbro, Stefan Eichhorn, and Andreas B. Imhoff. "The Anatomic Reconstruction of Acromioclavicular Joint Dislocations Using 2 TightRope Devices." American Journal of Sports Medicine 36, no. 12 (2008): 2398–406. http://dx.doi.org/10.1177/0363546508322524.

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Background For the reconstruction of acromioclavicular (AC) joint separation, several operative procedures have been described; however, the anatomic reconstruction of both coracoclavicular ligaments has rarely been reported. Purpose The aim of this biomechanical study is to describe a new procedure for anatomic reconstruction of the AC joint. Study Design Controlled laboratory study. Materials and Methods Forty fresh-frozen cadaveric shoulders were tested. Cyclic loading and a load-to-failure protocol was performed in vertical (native, n = 10; reconstructed, n = 10) and anterior directions (n

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19

Laganà, Alessandro, Giovanni Manfredi Assanto, Chiara Masucci, et al. "Secondary prophylaxis of venous thromboembolism (VTE) with low dose apixaban or rivaroxaban: results from a patient population with more than 2 years of median follow-up." Mediterranean Journal of Hematology and Infectious Diseases 16, no. 1 (2024): e2024020. http://dx.doi.org/10.4084/mjhid.2024.020.

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Background: Direct oral anticoagulants (DOACs) are widely used for the treatment and secondary prophylaxis of venous thromboembolism (VTE). Nowadays, DOACs represent the gold standard for long-term anticoagulation, with low-intensity DOACs administration becoming increasingly used worldwide in such scenario. Albeit low-intensity apixaban and rivaroxaban are approved for clinical usage as secondary VTE prophylaxis, there are few literature data regarding their efficacy and safety with a long follow-up. Objectives: The aim of our study was to evaluate the efficacy and safety of low-dose DO

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20

Dombret, Hervé, Alexandra Coelho, Laurène Fenwarth, et al. "Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study." Blood 144, Supplement 1 (2024): 2424. https://doi.org/10.1182/blood-2024-207226.

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Introduction. AML treatment options have been recently enriched. New agents like gemtuzumab ozogamicin (GO), FLT3 or IDH inhibitors, or CPX-351 have been approved for some patient subsets. Less-intensive options, like the AZA-VEN combination, are used in older/unfit patients. However, while treatments and indications are standardized, their choice is not, depending on often-subjective factors. This makes observational studies so important to describe the real-life management and outcomes of AML patients. Methods. In 2022, the ALFA group initiated a 2-cohort (newly diagnosed, relapsed/refractor

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21

Sobrevilla-Moreno, Nora, Josette Staufert-Gutiérrez, Ruben Rodriguez-Bautista, et al. "Impact of bleomycin shortage in patients with advanced testicular non-seminoma germ-cell tumors: A middle-income country cancer center experience." Journal of Clinical Oncology 43, no. 5_suppl (2025): 623. https://doi.org/10.1200/jco.2025.43.5_suppl.623.

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623 Background: Standard of care for advanced NSGCTs is BEP (bleomycin, etoposide, cisplatin). Social, epidemiologic and economic factors can impact drug availability. In our institution, the COVID-19 pandemic limited accessibility to several antineoplastic drugs, including bleomycin. This analysis describes the frequency of BEP modifications and its impact in prognosis of intermediate (IP) and poor (PP) NSGCT treated at the National Cancer Institute in Mexico. Methods: Retrospective observational study performed from 2018 to 2022. Clinical characteristics and chemotherapy modifications were r

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Dunlop, Hayley, Evelyn Fitzpatrick, Kevin Kurti, et al. "Participation of Patients From Racial and Ethnic Minority Groups in Phase 1 Early Cancer Drug Development Trials in the US, 2000-2018." JAMA Network Open 5, no. 11 (2022): e2239884. http://dx.doi.org/10.1001/jamanetworkopen.2022.39884.

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ImportanceDespite federal initiatives encouraging the enrollment of individuals from racial and ethnic minority groups in US clinical trials, no studies to date have specifically examined demographic disparities among participants in phase 1 drug development trials for patients with metastatic cancer.ObjectiveTo assess trends in the enrollment of patients from racial and ethnic minority groups in US phase 1 therapeutic drug trials for metastatic cancer from 2000 to 2018.Design, Setting, and ParticipantsIn this cross-sectional study, ClinicalTrials.gov was queried in July 2021 to identify compl

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Masatkar, Vaishali, Manju Meena, Rini Makhija, Chesta Agarwal, and Manisha Balai. "Clinico-Epidemiological Trends of Leprosy at a Tertiary Care Centre of South Rajasthan: A 10-Year Retrospective Study." Indian Journal of Dermatology 68, no. 6 (2023): 723. http://dx.doi.org/10.4103/ijd.ijd_370_23.

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Abstract Background: Leprosy is a major public health problem in India, which affects many people every year and has significantly high new case detection rates in certain districts and blocks. According to the National Leprosy Elimination Program (NLEP) report of March 2019, there were a total of 1.14 lakhs new cases of leprosy in India with an Annual New Case Detection Rate (ANCDR) of 8.1 per 100,000 population. Aim: The present study aimed at determining the epidemiological and clinical profile of leprosy patients from a tertiary level teaching hospital in South Rajasthan. Materials and Met

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Suttorp, Meinolf, Ralf Knoefler, Hélène Deutsch, et al. "High Platelet Counts, Thrombosis, Bleeding Signs, and Acquired Von Willebrand Syndrome at Diagnosis of Pediatric Chronic Myeloid Leukemia." Blood 134, Supplement_1 (2019): 4152. http://dx.doi.org/10.1182/blood-2019-123343.

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Background: At diagnosis of chronic myeloid leukemia (CML) patients (pats) may present with elevated platelets (PLT) counts. Generally, high PLT counts may result in thrombosis and/or bleeding complications, the latter being due to binding of von Willebrand factor (VWF) multimers to platelets. Pediatric CML is very rare (Hijiya N, Suttorp M 2019; Blood 33:2374-2384) and no systematic investigation on clinical complications of elevated PLT counts has so far been reported. Methods: Data on PLT counts and associated thrombo-hemorrhagic complications were retrospectively analyzed in newly diagnose

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Kufeldt, Johannes, Marketa Kovarova, Michael Adolph, et al. "Prevalence and Distribution of Diabetes Mellitus in a Maximum Care Hospital: Urgent Need for HbA1c-Screening." Experimental and Clinical Endocrinology & Diabetes 126, no. 02 (2017): 123–29. http://dx.doi.org/10.1055/s-0043-112653.

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Abstract Objective Diabetes mellitus affects almost one in 10 individuals in Germany. So far, little is known about the diabetes prevalence in maximum care hospitals. We assessed the diabetes prevalence, proportion of undiagnosed cases, the effectiveness of diabetes screening in a university hospital, the consequences for hospital stay and acquired complications. Research Design and Methods Over a 4 week period we determined HbA1c from 3 733 adult patients which were hospitalized at the university hospital of Tuebingen and had an available blood sample. Diabetes diagnosis was defined as HbA1c≥

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Al-Awadhi, Aydah, Mohammed Hourani, Mawada Hussein, et al. "Abstract P1-14-01: Incidence, Clinicopathological Features and Treatment Outcomes Of Young Breast Cancer Patients: A Cohort Analysis From a High-Volume Tertiary Cancer Center in The United Arab Emirates." Cancer Research 83, no. 5_Supplement (2023): P1–14–01—P1–14–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-p1-14-01.

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Abstract Introduction: Breast cancer (BC) in women age 40 or younger represents approximately 7% of all BC cases. Studies have reported that BC in younger women is more likely to have adverse tumor characteristics and outcomes when compared to elder women. Despite the fact that BC in the Middle East seems to occur at a younger age, data on tumor characteristics in these patients are scarce, especially in the United Arab Emirates. Objective: This study was conducted to investigate the incidence, clinicopathological characteristics, treatment modalities, and outcomes of young BC patients at a ma

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Park, Minah, Alex R. Cook, Jue Tao Lim, Yinxiaohe Sun, and Borame L. Dickens. "A Systematic Review of COVID-19 Epidemiology Based on Current Evidence." Journal of Clinical Medicine 9, no. 4 (2020): 967. http://dx.doi.org/10.3390/jcm9040967.

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As the novel coronavirus (SARS-CoV-2) continues to spread rapidly across the globe, we aimed to identify and summarize the existing evidence on epidemiological characteristics of SARS-CoV-2 and the effectiveness of control measures to inform policymakers and leaders in formulating management guidelines, and to provide directions for future research. We conducted a systematic review of the published literature and preprints on the coronavirus disease (COVID-19) outbreak following predefined eligibility criteria. Of 317 research articles generated from our initial search on PubMed and preprint a

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Weisel, Katja, Meletios A. Dimopoulos, Michele Cavo, et al. "Pomalidomide + Low-Dose Dexamethasone in Patients with Refractory or Relapsed and Refractory Multiple Myeloma and Renal Impairment: Analysis of Patients from the Phase 3b Stratus Trial (MM-010)." Blood 124, no. 21 (2014): 4755. http://dx.doi.org/10.1182/blood.v124.21.4755.4755.

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Abstract Background: Treatment (Tx) with novel agents, including lenalidomide (LEN) and bortezomib (BORT), has extended survival of patients (pts) with multiple myeloma (MM); however, pts who have relapsed on or become refractory to Tx have significantly shortened overall survival (OS) and poorer outcomes (Kumar, Leukemia, 2012). Renal impairment (RI) occurs frequently, in approximately 20% to 40% of MM pts (Kastritis, Haematologica, 2007), and is a leading cause of death in this pt population (Korbet, J Am Soc Nephrol, 2006). In the phase 3 MM-003 trial, pomalidomide plus low-dose dexamethaso

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Saura, Cristina, Mafalda Oliveira, Yin-Hsun Feng, et al. "Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in HER2-Positive Metastatic Breast Cancer Previously Treated With ≥ 2 HER2-Directed Regimens: Phase III NALA Trial." Journal of Clinical Oncology 38, no. 27 (2020): 3138–49. http://dx.doi.org/10.1200/jco.20.00147.

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PURPOSE NALA (ClinicalTrials.gov identifier: NCT01808573 ) is a randomized, active-controlled, phase III trial comparing neratinib, an irreversible pan-HER tyrosine kinase inhibitor (TKI), plus capecitabine (N+C) against lapatinib, a reversible dual TKI, plus capecitabine (L+C) in patients with centrally confirmed HER2-positive, metastatic breast cancer (MBC) with ≥ 2 previous HER2-directed MBC regimens. METHODS Patients, including those with stable, asymptomatic CNS disease, were randomly assigned 1:1 to neratinib (240 mg once every day) plus capecitabine (750 mg/m2 twice a day 14 d/21 d) wit

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De La Vega, Sofia Barlocco, Evelyne Guerif-Dubreucq, Jebrane Bouaoud, et al. "Mixed reality versus manikins in basic life support simulation-based training for medical students in France: the mixed reality non-inferiority randomized controlled trial." Journal of Educational Evaluation for Health Professions 22 (May 12, 2025): 15. https://doi.org/10.3352/jeehp.2025.22.15.

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Purpose: To compare the effectiveness of mixed reality with traditional manikin-based simulation in basic life support (BLS) training, testing the hypothesis that mixed reality is non-inferior to manikin-based simulation.Methods: A non-inferiority randomized controlled trial was conducted. Third-year medical students were randomized into 2 groups. The mixed reality group received 32 minutes of individual training using a virtual reality headset and a torso for chest compressions (CC). The manikin group participated in 2 hours of group training consisting of theoretical and practical sessions u

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Law, Jeanna Wallenta, Zartash Gul, Anna Berry, et al. "Abstract 6259: Molecular biomarker testing and targeted therapy patterns in patients with acute myelogenous leukemia (AML): A real-world data analysis." Cancer Research 82, no. 12_Supplement (2022): 6259. http://dx.doi.org/10.1158/1538-7445.am2022-6259.

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Abstract Background and Objective: Molecular testing and targeted treatments for patients (pts) diagnosed with AML have evolved in recent years. Real-world testing patterns, including next-generation sequencing (NGS), and clinical management of pts with AML were analyzed in 2 large U.S. community health systems. Methods: Pts &gt;18 years, diagnosed with AML from January 1, 2015 to December 31, 2020, were identified in a database containing clinical and genomic data from integrated community delivery networks. Study end was March 31, 2021, allowing for 3 months minimum follow up. Actionable

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Gebhardt, Jordan T., Jason C. Woodworth, Mike D. Tokach, et al. "Determining the influence of chromium propionate and Yucca schidigera on growth performance and carcass composition of pigs housed in a commercial environment1." Translational Animal Science 3, no. 4 (2019): 1275–85. http://dx.doi.org/10.1093/tas/txz117.

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Abstract Two experiments were conducted to determine the effects of feeding chromium propionate (Cr; Kemin Industries, Inc., Des Moines, IA) and a Yucca schidigera-based extract (YS; Distributors Processing, Inc., Porterville, CA) on growth performance of finishing pigs housed in commercial conditions. In experiment 1, a total of 1,188 pigs (PIC 337 × 1050; initially 27.3 ± 0.48 kg body weight [BW]) with 27 pigs per pen and 11 pens per treatment were split by sex upon arrival at the facility and were randomly allotted to groups of four pens blocked by BW. Diets were corn–soybean meal-dried dis

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Vogels, Birgit A. P. M., Martinus A. W. Maas, Anne Bosma, and Robert A. F. M. Chamuleau. "Significant Improvement of Survival by Intrasplenic Hepatocyte Transplantation in Totally Hepatectomized Rats." Cell Transplantation 5, no. 3 (1996): 369–78. http://dx.doi.org/10.1177/096368979600500303.

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The effect of intrasplenic hepatocyte transplantation (HTX) was studied in an experimental model of acute liver failure in rats with chronic liver atrophy. Rats underwent a portacaval shunt operation on Day -14 to induce liver atrophy, and underwent total hepatectomy on Day 0 as a start of acute liver failure. Intrasplenic hepatocyte or sham transplantation was performed on Day -7, -3, or -1 (n = 4 to 6 per group). During the period following hepatectomy, mean arterial blood pressure was maintained above 80 mm Hg and hypoglycaemia was prevented. Severity of hepatic encephalopathy was assessed

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Kwong, Ava, Cecilia Y. S. Ho, Henry C. M. Leung, Amy W. S. Leung, Chun-Hang Au, and Edmond S. K. Ma. "Mutation Spectrum Comparison between Benign Breast Lesion Cohort, Unselected Cancer Cohort and High-Risk Breast Cancer Cohort." Cancers 16, no. 17 (2024): 3066. http://dx.doi.org/10.3390/cancers16173066.

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Mutation study for high-risk breast and ovarian cancer (HBOC) has been extensively studied in patients of different ethnicities. Here we compared the germline mutation rate and mutation spectrum of patients (n = 4341) with benign breast diseases or breast cancers, with and without other risk factors. Three cohorts of Chinese patients were recruited. The first cohort, high-risk cohort (HR, n = 3935) included high-risk breast cancer patients fulfilling high-risk HBOC criteria and who are recruited at our genetics clinic. The second cohort, unselected cancer cohort (CC, n = 307) was from general

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Morris, M. E., and T. Trippenbach. "Changes in extracellular [K+] and [Ca2+] induced by anoxia in neonatal rabbit medulla." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 264, no. 4 (1993): R761—R769. http://dx.doi.org/10.1152/ajpregu.1993.264.4.r761.

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Ion-selective microelectrodes were used to record levels of extracellular K+ and Ca2+ concentrations ([K+]o and [Ca2+]o, respectively) and the changes evoked by anoxia in the medulla of anesthetized ventilated newborn rabbits, 1-14 days of age. Resting levels of [K+]o showed significant decline with increasing age. The mean initial level of [K+]o was 6.5 +/- 0.3 mM for the 1st neonatal wk and 5.1 +/- 0.4 mM for the 2nd wk. Brief periods of N2 inhalation (1-3 min) induced reversible increases in [K+]o that were smaller with progression of maturity. The duration of the initial increase (phase I)

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Van der Heijde, D., X. Baraliakos, M. Dougados, et al. "OP0019 BIMEKIZUMAB IN PATIENTS WITH ACTIVE ANKYLOSING SPONDYLITIS: 24-WEEK EFFICACY & SAFETY FROM BE MOBILE 2, A PHASE 3, MULTICENTRE, RANDOMISED, PLACEBO-CONTROLLED STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 12–13. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2441.

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BackgroundBimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. In a phase 2b study, BKZ showed rapid and sustained efficacy and was well tolerated up to 156 weeks (wks) in patients (pts) with active ankylosing spondylitis (AS).1,2ObjectivesTo assess efficacy and safety of BKZ vs placebo (PBO) in pts with active AS up to Wk 24 in the ongoing pivotal phase 3 study, BE MOBILE 2.MethodsBE MOBILE 2 (NCT03928743) comprises a 16-wk double-blind, PBO-controlled period and 36-wk maintenance period. Pts were aged ≥18 yrs, met modified New York criteria

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Cardoso, Matheus Völz, Giovanna Vicenzotti, Adriana Campos Passanezi Sant’Ana, Mariana Schutzer Ragghianti Zangrando, and Carla Andreotti Damante. "Reproducibility and comparison between methods for gingival color evaluation." Brazilian Journal of Oral Sciences 21 (July 4, 2022): e225946. http://dx.doi.org/10.20396/bjos.v21i00.8665946.

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Aim: This study aims to evaluate and validate the sensibility and the level of agreement between different gingival color measures obtained by a spectrophotometer (SPECTRO) and a photography (PHOTO) method. Methods: Among 40 patients, the color was measured 2 mm apical to the gingival margin by CIE L*, a*, b* system using a reflectance spectrophotometer and the photography’s plus software. The level of agreement between three different measures (m1, m2, m3) in parameters L*, a*, b*, and ΔE (color variation) was evaluated by random and systematic errors, as well as the limits and coefficient of

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Meyer, Romain A., Marcel Neeleman, Fabian Walter, and Bram Venemans. "ALMA 300 pc Resolution Imaging of a z = 6.79 Quasar: No Evidence for Supermassive Black Hole Influence on the C ii Kinematics." Astrophysical Journal 956, no. 2 (2023): 127. http://dx.doi.org/10.3847/1538-4357/acf047.

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Abstract We present Atacama Large Millimeter/submillimeter Array (ALMA) [C ii] 158 μm and dust continuum observations of the z = 6.79 quasar J0109–3047 at a resolution of 0.″045 (∼300 pc). The dust and [C ii] emission are enclosed within a ∼500 pc radius, with the central beam (r < 144 pc) accounting for ∼25% (8%) of the total continuum ([C ii]) emission. The far-infrared (FIR) luminosity density increases radially from ∼5 × 1011 L ⊙ kpc−2 to a central value of ∼70 × 1011 L ⊙ kpc−2 (SFRD ∼50–700 M ⊙yr−1 kpc−2). The [C ii] kinematics are dispersion dominated with a constant velocity dispersi

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Franco, J. A., M. J. GarcÌa, and V. Cros. "268 Nursery Irrigation Effects on Postplanting Root Dynamics of Limonium cossonianum O. Kuntze in Semi-arid Conditions." HortScience 34, no. 3 (1999): 488D—488. http://dx.doi.org/10.21273/hortsci.34.3.488d.

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A study was conducted with Limonium cossonianum O. Kuntze to analyze the influence of irrigation regime in nursery on the dynamics of root development after being transplanted with minimum management conditions. Plants were potgrown in a greenhouse. Each plant was potted into 625-mL plastic pot filled with a 1 silica sand medium: 1 peat mixture (v/v) amended with osmocote plus (3.7 g•kg-1 substrate). Drip irrigation was used with a 2-L•h-1 emitter per plant. Two irrigation treatments were used: T3, plants watered 6 days a week at the water-holding capacity (leaching 20% of the applied water) a

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Dayani, O., G. Ghorbani, T. Entz, et al. "Effect of dietary soybean or sunflower seeds on milk production, milk fatty acid profile and yield of conjugated linoleic acid." Canadian Journal of Animal Science 84, no. 1 (2004): 113–24. http://dx.doi.org/10.4141/a03-042.

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Eight cows in mid-lactation were used to determine the effects of feeding diets containing soybeans (SBS) or sunflower seed (SFS) on conjugated linoleic acid (CLA) yield and concentration in milk during two 3-wk periods. All cows were fed a standard pre-trial diet for 2 wk, before assignment to treatment diets in both periods of the 2 × 2 cross-over design used in the study. The two treatment diets contained on a dry matter (DM) basis: (1) SBS: 20% barley silage, 34.7% barley grain, 30% alfalfa cube, 13% crushed soybean seed and 0.36% sunflower oil, and (2) SFS: 17% barley silage, 34.6% barley

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Vogt, Florian, Peter Hunold, Julian Haegele, Erik Stahlberg, Jörg Barkhausen, and Jan Goltz. "Comparison of the Revenue Situation in Interventional Radiology Based on the Example of Peripheral Artery Disease in the Case of a DRG Payment System and Various Internal Treatment Charges." RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 190, no. 04 (2018): 348–58. http://dx.doi.org/10.1055/s-0043-121471.

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Purpose Calculation of process-orientated costs for inpatient endovascular treatment of peripheral artery disease (PAD) from an interventional radiology (IR) perspective. Comparison of revenue situations in consideration of different ways to calculate internal treatment charges (ITCs) and diagnosis-related groups (DRG) for an independent IR department. Materials and Methods Costs (personnel, operating, material, and indirect costs) for endovascular treatment of PAD patients in an inpatient setting were calculated on a full cost basis. These costs were compared to the revenue situation for IR f

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Bekkali, Noor, Manu Nayar, John Leeds, Richard Charnley, Matthew Huggett, and Kofi Oppong. "A comparison of outcomes between a lumen-apposing metal stent with electrocautery-enhanced delivery system and a bi-flanged metal stent for drainage of walled-off pancreatic necrosis." Endoscopy International Open 05, no. 12 (2017): E1189—E1196. http://dx.doi.org/10.1055/s-0043-120831.

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Abstract Background and study aims Bi-flanged metal stents (BFMS) have shown promise in the drainage of walled-off pancreatic necrosis (WON), but their placement requires multiple steps and the use of other devices. More recently, a novel device consisting of a combined lumen-apposing metal stent (LAMS) and electrocautery-enhanced delivery system has been introduced. The aim of this study was to compare the placement and outcomes of the two devices. Patients and methods This was a retrospective review of consecutive patients undergoing endoscopic ultrasound-guided placement of BFMS or LAMS for

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Köhm, M., A. C. Foldenauer, T. Rossmanith, et al. "POS0229 COMBINING MTX DOES NOT RESULT IN AN ADDITIONAL EFFICACY OF UST TREATMENT IN POLYARTHRITIC PSA: SUBGROUP ANALYSIS FROM A RANDOMIZED PLACEBO-CONTROLLED INVESTIGATOR INITIATED CLINICAL TRIAL." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 344–45. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4112.

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BackgroundBDMARD treatment in PsA patients usually requires treatment failure/intolerance to csDMARDs. The value of MTX in combination with bDMARDs is still unclear; an increase of efficacy is expected in polyarthritis. We designed an investigator-initiated, randomized, placebo-controlled trial (IIT) in active PsA to examine if outcomes of UST in combination with MTX (either newly initiated or ongoing) are different from UST only (+PBO), especially with focus on peripheral arthritic dominant PsA.ObjectivesTo compare ACR20/50/70 and MDA response rates at week 24 in treatment groups stratified b

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Albero, G., V. Longobardi, G. Zullo, et al. "144 INFLUENCE OF REPEATED OVUM PICKUP ON BUFFALO WELFARE." Reproduction, Fertility and Development 26, no. 1 (2014): 185. http://dx.doi.org/10.1071/rdv26n1ab144.

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The aim of this work was to evaluate the effect of repeated ovum pickup (OPU) on buffalo welfare. The OPU was carried out as previously described (Neglia et al. 2003 Theriogenology 59, 1123–1130) twice per week on 11 buffalo cows at 121 ± 15 days in milk for 2 months (end of October–end of December). Blood samples were collected before the beginning of the trial (time 0), after 1 month (time 1), and after 2 months (time 2) in animals that had undergone OPU and in control animals (n = 10) of the same herd. The following parameters of clinical immunology were evaluated on sera: haemolytic comple

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Carvalho, Renata da Silva Cuba de, Mara Rúbia Mendes de Melo, Francielly Guieiro Gomes de Sousa, Luís Roberto Almeida Gabriel Filho, Antonio Evaldo Klar, and Hélio Grassi Filho. "CARACTERIZAÇÃO FÍSICO-QUÍMICA DE SUBSTRATO DE FIBRA DE CASCA DE COCO APÓS O CULTIVO HIDROPÔNICO DE PIMENTÃO COM ÁGUA DE REÚSO E DIFERENTES LÂMINAS DE SOLUÇÃO NUTRITIVA." IRRIGA 1, no. 3 (2021): 613–27. http://dx.doi.org/10.15809/irriga.2021v1n3p613-627.

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CARACTERIZAÇÃO FÍSICO-QUÍMICA DE SUBSTRATO DE FIBRA DE CASCA DE COCO APÓS O CULTIVO HIDROPÔNICO DE PIMENTÃO COM ÁGUA DE REÚSO E DIFERENTES LÂMINAS DE SOLUÇÃO NUTRITIVA1 RENATA DA SILVA CUBA DE CARVALHO2; MARA RÚBIA MENDES DE MELO3; fRANCIELLY GUIEIRO GOMES DE SOUSA4; luís roberto almeida gabriel filho5; antonio evaldo klar6 E hélio grassi filho7 1Trabalho originado da tese de doutorado do primeiro autor intitulada: “Cultivo de pimentão em sistema hidropônico com água de reúso em diferentes níveis de disponibilidade de água no substrato”. 2Doutora, Programa de Pós-graduação em Agronomia – Irrig

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Michelena, X., S. S. Zhao, S. Dubash, G. T. Jones, L. Dean, and H. Marzo-Ortega. "FRI0287 BIOLOGIC DRUG RESPONSE DOES NOT APPEAR RELATED TO RADIOGRAPHIC STATUS IN AXIAL SPONDYLOARTHRITIS: DATA FROM THE BSRBR-AS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 732.2–732. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3147.

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Background:The concept of axial spondyloarthritis (axSpA) incorporates the full range of inflammatory spinal disease. In the absence of specific immuno-genetic biomarkers, classification criteria differentiate two groups (non-radiographic [nr-axSpA] and radiographic axSpA [r-axSpA]) based on the presence of structural damage of the sacroiliac joints. Controversy remains as to whether nr-axSpA represents a milder form with biologic DMARD (bDMARD) treatment restrictions still in place in many countries.Table 1.Baseline characteristics of nr-axSpA and r-axSpA patients starting biologics.Variables

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Greenberg, P., G. Dine, A. Ganser, et al. "Deferasirox (Exjade®, ICL670) Demonstrates Dose-Related Effects on Body Iron Levels Related to Transfusional Iron Intake in Transfusion-Dependent Anemia." Blood 106, no. 11 (2005): 2694. http://dx.doi.org/10.1182/blood.v106.11.2694.2694.

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Abstract Iron overload, a potentially serious consequence of multiple blood transfusions, can be effectively managed with chelation therapy. Deferasirox, an investigational once-daily oral chelator, has been evaluated in a 1 year study of iron-overloaded adult and pediatric patients (n=184) with transfusion-dependent anemia including β-thalassemia, myelodysplastic syndromes (MDS) and Diamond-Blackfan anemia (DBA). Patients were stratified into four daily dose groups (5, 10, 20 and 30 mg/kg) according to baseline liver iron concentration (LIC; 2–3, &gt;3–7, &gt;7–14 and &gt;14 mg Fe

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Kaijser, Magnus, Cecilia Johnsson, Lilija Zezina, Ulla Backman, Emöke Dimény, and Bengt Fellström. "Elevation of cyclosporin A blood levels during carvedilol treatment in renal transplant patients." Clinical Transplantation 11, no. 6 (1997): 577–81. http://dx.doi.org/10.1111/j.1399-0012.1997.tb01046.x.

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In a consecutive study of 21 renal transplant patients suffering from chronic vascular rejection (CVR) we added the beta‐receptor‐blocking drug carvedilol to their regular medication. The purpose was to investigate possible pharmacokinetic interactions between carvedilol and cyclosporine (CSA), since carvedilol will soon be used in clinical trials in renal transplant patients with CVR. On the first day of the study the patients received 6.25 mg of carvedilol added to their daily medication. The dose was increased stepwise to 50 mg while the doses of other beta‐blocking drugs were decreased. Th

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Casiraghi, Monica, Domenico Galetta, Alessandro Borri, et al. "Ten Years' Experience in Robotic-Assisted Thoracic Surgery for Early Stage Lung Cancer." Thoracic and Cardiovascular Surgeon 67, no. 07 (2018): 564–72. http://dx.doi.org/10.1055/s-0038-1639575.

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Background This study analyzed the short- and long-term outcomes of robotic-assisted thoracic surgery (RATS) for early stage non-small cell lung cancer (NSCLC). Methods From November 2006 to December 2016, we performed 363 RATS procedures. This study retrospectively reviewed 339 patients who underwent RATS for clinical stages I (n = 318) or II (n = 21) NSCLC. Results Twenty-nine patients underwent segmentectomy, 307 lobectomy, and 3 pneumonectomy. Conversion occurred in 22 patients (6.5%): 15 (4.4%) due to technical issues, 4 (1.2%) for oncological reasons, and 3 (0.9%) for bleeding. The media

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Ruther, Nancy R., Alcee Jumonville, Michelle A. Mathiason, Ann E. Emmel, Sandra K. Wee, and Ronald S. Go. "Speed of accrual into published phase III oncology trials: A comparison across geographic locations." Journal of Clinical Oncology 30, no. 15_suppl (2012): 6074. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6074.

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6074 Background: There is a perception that patient accrual may be slower in the US than it is in Europe (Wang-Gillam A et al, J Clin Oncol 2010;28:3803-3807). However, a systematic study has not been performed. We seek to determine the speed at which patients are accrued into published phase III oncology trials across geographic locations and to identify factors that may influence this process. Methods: We searched MEDLINE and identified all original phase III oncology therapeutic trials published in 2006-2010 (N = 567). Trials with no reported activation and completion dates were excluded (n

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