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Статті в журналах з теми "347.82.001 (043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Newton, Kathryn T., and Aaron Ashley. "Introducing the Interdisciplinary Nature of Health Care Through Case Study Models." Journal of Education and Training Studies 8, no. 1 (2019): 20. http://dx.doi.org/10.11114/jets.v8i1.4600.

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Interprofessional education (IPE) is a critical area needed to improve the quality of healthcare. Stereotypes of other disciplines persist by healthcare workers, limiting the ability to work as a team. Knowledge of roles of healthcare professions is a key competency of IPE. An online, 12-week course was developed to introduce students to the interdisciplinary nature of healthcare through case study models. Through built-in links, students explore medical terminology, diagnostic testing, pathophysiology, treatment, and health professionals who work as a team to diagnose and treat the patient. A

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2

Wang, Michael S., Charlesnika T. Evans, Tulio Rodriguez, Dale N. Gerding, and Stuart Johnson. "Clostridium difficileInfection and Limitations of Markers for Severity in Patients with Hematologic Malignancy." Infection Control & Hospital Epidemiology 34, no. 2 (2013): 127–32. http://dx.doi.org/10.1086/669081.

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Objective.To describe characteristics ofClostridium difficileinfection (CDI) and markers of severe CDI among patients with hematologic malignancies.Design.Case-control study.Setting.Tertiary care teaching hospital.Patients and Methods.Inpatients with hematologic malignancies and CDI were age and time matched with 2 control inpatients without hematologic malignancies. Chart reviews were performed, andC. difficileisolates were strain typed.Results.Case patients (n= 41) and control patients (n= 82) patients were different in respect to receipt of immunosuppressive agents within 2 months (92.7% vs

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3

Carmagnani Pestana, Roberto, Manal Hassan, Reham Abdel-Wahab, et al. "Plasma GH as a diagnostic and prognostic biomarker in HCC without cirrhosis." Journal of Clinical Oncology 37, no. 4_suppl (2019): 227. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.227.

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227 Background: The association between the GH/IGF-1 axis and HCC was reported in patients (pt) with underlying cirrhosis. However, there is limited information among HCC pt without (w/o) cirrhosis. We herein investigated the role of GH as a circulating biomarker for HCC diagnosis and prognosis in pt w/o cirrhosis. Methods: Under IRB approval, we prospectively enrolled 1267 newly-diagnosed HCC pt in a case control study at the MD Anderson Cancer Center (2000-2015). Controls were healthy individuals (n = 1104). Plasma GH and AFP were measured 274 HCC pt w/o cirrhosis 200 healthy controls. IGF-1

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4

Davey, Matthew G., Éanna J. Ryan, Daniel Burke, et al. "Evaluating the Clinical Utility of Routine Sentinel Lymph Node Biopsy and the Value of Adjuvant Chemotherapy in Elderly Patients Diagnosed With Oestrogen Receptor Positive, Clinically Node Negative Breast Cancer." Breast Cancer: Basic and Clinical Research 15 (January 2021): 117822342110222. http://dx.doi.org/10.1177/11782234211022203.

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Background: Sentinel lymph node biopsy (SLNB) provides staging information and guides adjuvant therapy in early breast cancer (EBC). Routine SLNB in oncogeriatricians with low-risk EBC remains controversial. Aims: To evaluate axillary management in elderly patients diagnosed with oestrogen receptor positive (ER+), clinically lymph node negative (cLN−) EBC, and to assess whether SLNB affects further axillary management or adjuvant chemotherapy (ACTX) decision making. Methods: Female patients aged > 65 years, diagnosed with ER+, human epidermal growth factor receptor-2 negative (HER2−), and c

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5

Hasrouni, Edy, Valeria Visconte, Ali Tabarroki, et al. "Pathway Analysis of Molecular Mutations Can Modify Morphologic, Cytogenetic and Prognostic Risk Stratification Schemes in Myelodysplastic Syndromes (MDS), Myelodysplastic Syndromes/Myeloproliferative Neoplasms (MDS/MPN), and Secondary Acute Myeloid Leukemia (AML)." Blood 120, no. 21 (2012): 3791. http://dx.doi.org/10.1182/blood.v120.21.3791.3791.

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Abstract Abstract 3791 Molecular mutations of genes important in MDS pathogenesis have been identified using next generation sequencing technologies. These mutations have variable effects on prognosis: results from individual studies are conflicting, and the impact of combining mutations based on pathogenetic pathways has not been explored. Furthermore, most studies do not take into account the types of therapies received by patients (pts). We hypothesized that analyses of mutations incorporating pathways would yield more meaningful results, especially if studied in the context of therapies. W

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6

Rhind, S. M., B. A. Morris, Jill Clayton, and G. Gittus. "Effect of level of food intake at mating on the reproductive performance of ewes passively immunized against testosterone." Animal Science 45, no. 1 (1987): 81–85. http://dx.doi.org/10.1017/s0003356100036655.

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AbstractIn a 2 × 2 × 2 experiment, 296 Scottish Blackface ewes were fed to achieve one of two levels of body condition (high: condition scores ^2·75; low: condition scores ^2·50) by 2 weeks before joining with rams. Half of the ewes of each condition score were fed dried grass pellets ad libitum and 300 g hay per head daily, between 2 weeks before and 8 days after joining, while the remaining ewes were offered a live-weight maintenance ration comprising 750 g pellets and 400 g hay per head daily. From 8 days after joining the intake of all ewes was gradually changed, over a 2-week period, to 1

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7

Leung, Nelson, Shaji Kumar, Angela Dispenzieri, et al. "Comparison of Troponin T and N-Terminal-Pro-Brain Natriuretic Peptides In Two Models of Treatment Related Mortality In AL Amyloidosis Patients Following Autologous Stem Cell Transplantation." Blood 116, no. 21 (2010): 3572. http://dx.doi.org/10.1182/blood.v116.21.3572.3572.

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Abstract Abstract 3572 High dose melphalan and autologous stem cell transplantation (ASCT) is an effective treatment for light chain amyloidosis (AL) but high treatment related mortality (TRM) limits its use. Both cardiac troponin T (cTnT) and N-terminal-pro-brain natriuretic peptide (NT-pro-BNP) are sensitive predictors of high risk patients. Aim of this study is to compare two models of TRM, one using cTnT and the other BNP. Patients who underwent ASCT between 7/1996 and 7/2009 at the Mayo Clinic were analyzed retrospectively. Variables were chosen for ease of measurement and reproducibility

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8

Chukanov, Nikita V., Sergey M. Aksenov, Ramiza K. Rastsvetaeva, et al. "Antipinite, KNa3Cu2(C2O4)4, a new mineral species from a guano deposit at Pabellón de Pica, Chile." Mineralogical Magazine 79, no. 5 (2015): 1111–21. http://dx.doi.org/10.1180/minmag.2015.079.5.07.

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AbstractThe new oxalate mineral antipinite is found in a guano deposit located on the Pabellón de Pica Mountain, Iquique Province, Tarapacá Region, Chile. Associated minerals are halite, salammoniac, chanabayaite, joanneumite and clays. Antipinite occurs as blue, imperfect, short prismatic crystals up to 0.1 mm × 0.1 mm × 0.15 mm in size, as well as their clusters and random aggregates. The mineral is brittle. Mohs hardness is 2; Dmeas = 2.53(3), Dcalc = 2.549 g cm–3. The infrared spectrum shows the presence of oxalate anions and the absence of absorptions associated with H2O molecules, C–H bo

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9

Jentzsch, Madlen, Marius Bill, Juliane Grimm, et al. "The Prognostic Impact of the Diagnostic CD34+/CD38- Cell Burden and Expression of the Stem Cell Marker GPR56 after Stem Cell Transplantation Depends on the AML Origin." Blood 134, Supplement_1 (2019): 323. http://dx.doi.org/10.1182/blood-2019-127544.

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Introduction: Acute myeloid leukemia (AML) developing secondary after other hematologic diseases, or therapy related after cytotoxic treatment for solid tumors or rheumatologic diseases (s/tAML) is clinically, genetically & prognostically distinct from de novo diseases. Data indicate that s/tAML patients (pts) have inferior outcome compared to de novo cases after chemotherapy & therefore often require consolidation therapy using allogeneic stem cell transplantation (HSCT). Leukemic stem cells (LSC) initiate & maintain AML. They are also believed to exist within the CD34+/CD38- &amp

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10

Brinkworth, Grant D., Thomas P. Wycherley, Pennie J. Taylor, and Campbell H. Thompson. "A Health Care Professional Delivered Low Carbohydrate Diet Program Reduces Body Weight, Haemoglobin A1c, Diabetes Medication Use and Cardiovascular Risk Markers—A Single-Arm Intervention Analysis." Nutrients 14, no. 20 (2022): 4406. http://dx.doi.org/10.3390/nu14204406.

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This study examined the effectiveness of a health care professional delivered low-carbohydrate diet program (Diversa Health Program) aiming to improve obesity/type-2-diabetes management for people living in Australia. 511 adults (Age:57.1 ± 13.7 [SD] yrs) who participated between January 2017–August 2021 for ≥30 days with pre-post data collected for ≥1 key outcome variable (body weight and HbA1c) were included in the analysis. Average participation duration was 218 ± 207 days with 5.4 ± 3.9 reported consultation visits. Body weight reduced from 92.3 ± 23.0 to 86.3 ± 21.1 kg (n = 506, p < 0.

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11

Rivera Teran, V., D. Alpizar-Rodriguez, S. Sicsik, et al. "FRI0546 GENDER DIFFERENCES OF RHEUMATIC DISEASES IN MEXICAN POPULATION: DATA FROM THE MEXICAN BIOLOGICS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 874–75. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6091.

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Background:Most autoimmune diseases are more prevalent in women. Symptom severity, disease progression, response to therapy and overall survival differ between males and females with rheumatic diseases.Objectives:To identify the characteristics of autoimmune diseases presentation and treatment between male and female population using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican ongoing cohort that collects the information of patients using biologic and biosimilar drugs since 2016. For this study we included all patients enrolled in the regis

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12

Boavida Ferreira, João, Vasanth Subramanian, Ye Y. Xiang, et al. "PORTO-001 study: Changes in the oral microbiome and matrix metalloproteinases in patients with oropharyngeal squamous cell carcinoma undergoing definitive chemoradiotherapy." Journal of Clinical Oncology 41, no. 16_suppl (2023): e18034-e18034. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e18034.

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e18034 Background: Head and neck cancer patients treated with concurrent chemoradiotherapy (CRT) develop oral mucositis, with varying severity. However, knowledge about risk factors, biomarkers, treatment, and prognosis of oral mucositis is still limited. Methods: We designed an exploratory study to examine the changes in the oral microbiome and salivary and plasma levels of matrix metalloproteinases (MMP) in patients with locoregionally advanced oropharyngeal squamous cell carcinoma (OPSCC) undergoing definitive CRT. Patients were followed from screening to week 7 of treatment with CRT, which

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13

Wong, Robert J., Patricia D. Jones, Bolin Niu, et al. "Clinician-Level Knowledge and Barriers to Hepatocellular Carcinoma Surveillance." JAMA Network Open 7, no. 5 (2024): e2411076. http://dx.doi.org/10.1001/jamanetworkopen.2024.11076.

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ImportanceSurveillance for hepatocellular carcinoma (HCC) in patients with cirrhosis is underused. Identifying potentially modifiable factors to address barriers in HCC surveillance is critical to improve patient outcomes.ObjectiveTo evaluate clinician-level factors contributing to underuse of HCC surveillance in patients with cirrhosis.Design, Setting, and ParticipantsThis survey study included primary care clinicians (PCCs) and gastroenterology and hepatology clinicians at 5 safety-net health systems in the US. Clinicians were surveyed from March 15 to September 15, 2023, to assess knowledge

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14

Oi, Takanori, Shinichi Yoshiya, Jon Slowik, et al. "Biomechanical Differences Between Japanese and American Professional Baseball Pitchers." Orthopaedic Journal of Sports Medicine 7, no. 2 (2019): 232596711982562. http://dx.doi.org/10.1177/2325967119825625.

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Background: Although baseball injuries are common in both Japan and the United States, the majority of pitching injuries in Japanese players occur at the shoulder, whereas most pitching injuries in American players occur at the elbow. A biomechanical comparison between Japanese and American pitchers may help to identify the different injury mechanisms. Hypothesis: Japanese pitchers produce greater shoulder kinetics whereas American pitchers generate greater elbow kinetics. Also, kinematic differences will be found between the 2 groups, including longer stride and greater lead knee flexion for

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15

Lybimova, N., I. Fridman, O. Goleva, et al. "FRI0461 THE ANTI-VACCINE ANTIBODY AGAINST MEASLES, PAROTITIS, RUBELLA, DIPHTHERIA AND HEPATITIS B IN 170 JUVENILE IDIOPATHIC ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 827.1–828. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6072.

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Background:Patients with juvenile idiopathic arthritis (JIA) may have lower protective levels of anti-vaccine antibodies due to high inflammatory activity, interrupted or incomplete vaccination schedule, and due to using of immune-modulating drugs, e.g. systemic corticosteroids (CS), methotrexate (MTX) and biologics.Objectives:The aim of our study was to find the predictors of low levels of anti-vaccine antibodies in patients with JIA.Methods:In the present study were included data 170 JIA (55 boys and 115 girls) aged from 2 to 17 years, who received scheduled vaccination before the age of 2 y

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16

Corti, Chiara, Tianyu Li, Alyssa R. Martin, et al. "Abstract P5-10-17: Impact of Pathologic Response and Individual Prognosis After Neoadjuvant Treatment (NAT) in Patients (pts) with Early HER2+ and Triple-Negative Breast Cancer (TNBC)." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–10–17—P5–10–17. https://doi.org/10.1158/1557-3265.sabcs24-p5-10-17.

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Abstract Background: Pathologic complete response (pCR) is prognostic in pts with early breast cancer (eBC). This study aims to assess individual prognostic factors for recurrence-free survival (RFS) and overall survival (OS) in pts with pCR vs residual disease (RD). Methods: This retrospective study included pts diagnosed at our institution with TNBC or HER2+ eBC who underwent surgery post-NAT and had available data for pCR/RD, RFS, OS. Clinical tumor size (cT), nodal status (cN), and subtype were evaluated as prognostic factors using Cox models and Kaplan-Meier method, in all pts and in pts

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17

Van der Heijde, D., X. Baraliakos, M. Dougados, et al. "OP0019 BIMEKIZUMAB IN PATIENTS WITH ACTIVE ANKYLOSING SPONDYLITIS: 24-WEEK EFFICACY & SAFETY FROM BE MOBILE 2, A PHASE 3, MULTICENTRE, RANDOMISED, PLACEBO-CONTROLLED STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 12–13. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2441.

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BackgroundBimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. In a phase 2b study, BKZ showed rapid and sustained efficacy and was well tolerated up to 156 weeks (wks) in patients (pts) with active ankylosing spondylitis (AS).1,2ObjectivesTo assess efficacy and safety of BKZ vs placebo (PBO) in pts with active AS up to Wk 24 in the ongoing pivotal phase 3 study, BE MOBILE 2.MethodsBE MOBILE 2 (NCT03928743) comprises a 16-wk double-blind, PBO-controlled period and 36-wk maintenance period. Pts were aged ≥18 yrs, met modified New York criteria

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de Batlle, Jordi, Mireia Massip, Eloisa Vargiu, et al. "Implementing Mobile Health–Enabled Integrated Care for Complex Chronic Patients: Intervention Effectiveness and Cost-Effectiveness Study." JMIR mHealth and uHealth 9, no. 1 (2021): e22135. http://dx.doi.org/10.2196/22135.

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Background Integrated care can generate health and social care efficiencies through the defragmentation of care and adoption of patient-centered preventive models. eHealth can be a key enabling technology for integrated care. Objective The aim of this study was to assess the effectiveness and cost-effectiveness of the implementation of a mobile health (mHealth)-enabled integrated care model for complex chronic patients. Methods As part of the CONNECARE Horizon 2020 project, a prospective, pragmatic, two-arm, parallel implementation trial was held in a rural region of Catalonia, Spain. During 3

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Jelinek, Michael J., Alicia J. Wyche, Claudia Wing, et al. "Urine cystatin C (uCyC) as a predictor for acute kidney injury (AKI) in urothelial cancer (UC) patients (pts) treated with cisplatin (CDDP)." Journal of Clinical Oncology 33, no. 7_suppl (2015): 317. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.317.

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317 Background: CDDP-based treatment is limited by AKI. We aimed to test whether a novel AKI biomarker, uCyC, measured before and immediately after CDDP administration could permit earlier identification of UC pts at risk for AKI. Methods: In a nested case-control study, pts treated with CDDP were prospectively enrolled. uCyC was measured 2 hours pre- and 3 hours post-CDDP doses, with values normalized to urine creatinine. AKI was defined as an increase in serum creatinine (sCr) by ≥50% (severe cases) or ≥0.3 mg/dL above pre-CDDP baseline. Controls were pts with no significant sCr rise (sCr ch

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Handa, Nobuhiro, Seigo Mitsutake, Tatsuro Ishizaki, et al. "Associations of coprescribed medications for chronic comorbid conditions in very old adults with clinical dementia: a retrospective cohort study using insurance claims data." BMJ Open 11, no. 7 (2021): e043768. http://dx.doi.org/10.1136/bmjopen-2020-043768.

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ObjectiveTo assess the association of coprescribed medications for chronic comorbid conditions with clinical dementia in older adults, as indicated by the initiation of a new prescription of antidementia medication (NPADM).DesignRetrospective enumeration cohort study.SettingA Japanese city in Tokyo Metropolitan Area.ParticipantsA total of 42 024 adults aged ≥77 years residing in Kashiwa City, a suburban city of Tokyo Metropolitan Area, who did not have any prscription of antidementia medication from 1 April to 30 June 2012.Main outcome measureThe primary outcome was NPADM during follow-up peri

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Montoro, Maria Julia, Pamela Acha, Manja Meggendorfer, et al. "The Presence of SH2B3 mutations Identifies a Distinct Subtype of Myelodysplastic Neoplasms." Blood 144, Supplement 1 (2024): 3214. https://doi.org/10.1182/blood-2024-194488.

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Background & aim: SH2B3 is a gene involved in cell proliferation by negatively regulating the TPO/MPL/JAK2 pathway. Up to 7% of myeloproliferative neoplasms present mutations in this gene. However, the prevalence, prognosis, and mechanism of action of SH2B3 mutations in myelodysplastic neoplasms (MDS) are unknown. The study aimed to analyze the clinical characteristics and prognostic impact of SH2B3 mutations in patients with MDS. Methods: We included patients with MDS and chronic myelomonocytic leukemia dysplastic variant (CMML-MD) according to 2017 WHO criteria. The study group comprised

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Sierra-Díaz, Diana Carolina, Adrien Morel, Dora Janeth Fonseca, et al. "Abstract P3-07-05: Genetic profile of germline mutations in unselected women with breast cancer in a Colombian population." Cancer Research 82, no. 4_Supplement (2022): P3–07–05—P3–07–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-07-05.

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Abstract Introduction In Colombia Breast cancer (BC), is the most frequent and has the highest mortality rate among all types of cancer. There are few studies of the genomic profile in unselected affected population by BC in Colombia. Some of these studies have only tested the presence of variants reported as founders named “Colombian Profile”.We conducted a large-scale genomic analysis using Whole Exome Sequencing (WES) to evaluate germline mutations in unselected BC patients. Methods This trial included 299 unselected BC female patients aged over 18 years old, without personal and family his

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Dayani, O., G. Ghorbani, T. Entz, et al. "Effect of dietary soybean or sunflower seeds on milk production, milk fatty acid profile and yield of conjugated linoleic acid." Canadian Journal of Animal Science 84, no. 1 (2004): 113–24. http://dx.doi.org/10.4141/a03-042.

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Eight cows in mid-lactation were used to determine the effects of feeding diets containing soybeans (SBS) or sunflower seed (SFS) on conjugated linoleic acid (CLA) yield and concentration in milk during two 3-wk periods. All cows were fed a standard pre-trial diet for 2 wk, before assignment to treatment diets in both periods of the 2 × 2 cross-over design used in the study. The two treatment diets contained on a dry matter (DM) basis: (1) SBS: 20% barley silage, 34.7% barley grain, 30% alfalfa cube, 13% crushed soybean seed and 0.36% sunflower oil, and (2) SFS: 17% barley silage, 34.6% barley

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Hasegawa, Toshinori, Yoshihisa Kida, Takenori Kato, Hiroshi Iizuka, Shunichiro Kuramitsu, and Takashi Yamamoto. "Long-term safety and efficacy of stereotactic radiosurgery for vestibular schwannomas: evaluation of 440 patients more than 10 years after treatment with Gamma Knife surgery." Journal of Neurosurgery 118, no. 3 (2013): 557–65. http://dx.doi.org/10.3171/2012.10.jns12523.

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Object Little is known about long-term outcomes, including tumor control and adverse radiation effects, in patients harboring vestibular schwannomas (VSs) treated with stereotactic radiosurgery > 10 years previously. The aim of this study was to confirm whether Gamma Knife surgery (GKS) for VSs continues to be safe and effective > 10 years after treatment. Methods A total of 440 patients with VS (including neurofibromatosis Type 2) treated with GKS between May 1991 and December 2000 were evaluable. Of these, 347 patients (79%) underwent GKS as an initial treatment and 93 (21%) had underg

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Abeykoon, Jithma P., Shaji Kumar, Jorge J. Castillo, et al. "Bendamustine rituximab (BR) versus ibrutinib (Ibr) as primary therapy for Waldenström macroglobulinemia (WM): An international collaborative study." Journal of Clinical Oncology 40, no. 16_suppl (2022): 7566. http://dx.doi.org/10.1200/jco.2022.40.16_suppl.7566.

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7566 Background: Parenteral limited-duration BR chemoimmunotherapy and continuous orally administered Ibr, a Bruton tyrosine kinase inhibitor, dominate the treatment landscape of WM, a rare B cell lymphoma. No trials have assessed the comparative effectiveness of these 2 vastly different approaches. We conducted a multiinstitutional, international, collaborative study to compare BR and single-agent Ibr in patients (pts) with treatment naïve (TN) WM. Methods: Data from 347 pts with active TN WM, seen between 2011 and 2021 in the US and Europe, were analyzed. The pts on rituximab maintenance wer

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Bundgaard, Henning, Thomas A. Schmidt, Jim S. Larsen, and Keld Kjeldsen. "K+ supplementation increases muscle [Na+-K+-ATPase] and improves extrarenal K+homeostasis in rats." Journal of Applied Physiology 82, no. 4 (1997): 1136–44. http://dx.doi.org/10.1152/jappl.1997.82.4.1136.

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Bundgaard, Henning, Thomas A. Schmidt, Jim S. Larsen, and Keld Kjeldsen. K+supplementation increases muscle [Na+-K+-ATPase] and improves extrarenal K+homeostasis in rats. J. Appl. Physiol.82(4): 1136–1144, 1997.—Effects of K+ supplementation (∼200 mmol KCl/100 g chow) on plasma K+, K+ content, and Na+-K+-adeonsinetriphosphatase (ATPase) concentration ([Na+-K+-ATPase]) in skeletal muscles as well as on extrarenal K+ clearance were evaluated in rats. After 2 days of K+supplementation, hyperkalemia prevailed (K+-supplemented vs. weight-matched control animals) [5.1 ± 0.2 (SE) vs. 3.2 ± 0.1 mmol/l

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Babaytseva, T. A., and V. V. Slyusarenko. "Special features of productivity and seed quality development of winter triticale varieties under the influence of technological methods." Agricultural Science Euro-North-East 21, no. 2 (2020): 103–13. http://dx.doi.org/10.30766/2072-9081.2020.21.2.103-113.

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The article provides the results of three year (2017-2019) study of the effect of pre-sowing treatment of seeds and foliar fertilizing on productivity and seed qualities of winter triticale varieties (×Triticosecale Wittmack.) Izhevskaya 2 and Zimogor. The research was carried out in the conditions of the Udmurt Republic. Pre-sowing seed treatment was done with fungicide Vial TT, compound fertilizer Agree’s Forsazh and plant growth stimulant Mival-Agro in their pure form, with tank mixtures containing Vial TT fungicide, and with mineral fertilizer Emix. Foliar feeding with Agree’s Nitrogen Pot

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Davis III, J. M., E. Myasoedova, T. Gunderson, and C. S. Crowson. "THU0133 DIAGNOSES AND COMORBIDITIES IN PRE-RHEUMATOID ARTHRITIS: COMPARISON BETWEEN SEROPOSITIVE AND SERONEGATIVE PATIENTS AND MATCHED NON-RA SUBJECTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 282.2–282. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5071.

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Background:Previous studies have suggested that comorbidities accumulate before the clinical diagnosis of RA, i.e., ‘pre-RA’ (1). Understanding patterns of diagnoses and comorbidities during the pre-RA period may provide new insights into pathogenesis.Objectives:To elucidate diagnoses and comorbidities before the onset of clinically apparent RA compared to non-RA subjects, and for seropositive (RF and/or CCP positive) compared to seronegative (RF and CCP negative) patients with RA.Methods:Adult residents of Olmsted County, Minnesota, with incident RA in 1999-2013 fulfilling the 1987 ACR classi

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Le, Thuy, Hung Nguyen Thanh, Minh Ngo Ngoc Quang, et al. "Strengthening Adherence to a Central-Line–Associated Bloodstream Infection Prevention Bundle in a Surgical ICU in Vietnam." Infection Control & Hospital Epidemiology 41, S1 (2020): s392. http://dx.doi.org/10.1017/ice.2020.1031.

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Background: Central-line–associated bloodstream infections (CLABSIs) increase the length of hospital stay, healthcare costs, and patient mortality. Objective: We conducted a quality improvement (QI) approach with plan-do-study-act (PDSA) cycle to strengthen adherence to a central-line (CL) maintenance bundle and to reduce CLABSI rate in a surgical intensive care unit (ICU) of children’s hospital 1 (CH1). Methods: The baseline CLABSI rate per 1,000 CL days and the ratio of CL days to patient days (device utilization ration; DUR) were captured for 12 months preceding the intervention. Baseline p

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Mason, MG, WM Porter, and WJ Cox. "Effect of an acidifying nitrogen fertiliser and lime on soil pH and wheat yields. 1. Soil effects." Australian Journal of Experimental Agriculture 34, no. 2 (1994): 237. http://dx.doi.org/10.1071/ea9940237.

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Three long-term trials were commenced in 1980 at Merredin, Wongan Hills, and Newdegate to investigate the effect of an acidifying fertiliser containing 17.5% nitrogen (N) and 7.6% phosphorus (P) (based on ammonium sulfate and ammonium phosphate) on soil pH, soil acidity related problems, and wheat grain yields under continuous cropping. Treatments were 3 rates (kg/ha) of N + P applied with the cereal seed (nil; 17.5 N + 7.6 P; 35 N + 15.2 P), with or without 3 t/ha of ground limestone (with or without MgSO4, KCl, Moo3) applied in 1980. Two extra treatments were 2 rates of limestone (70, 140 kg

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Flouri, I., A. Repa, N. Avgustidis, et al. "AB0375 IN PATIENTS STARTING ETANERCEPT, MALE SEX, ABSENCE OF COMORBIDITIES AND NO csDMARDs CO-ADMINISTRATION ARE INDEPENDENT PREDICTORS OF LONG-TERM (MORE THAN 3 YEARS) PERSISTENCE TO THERAPY, IRRESPECTIVELY OF THE CLINICAL DIAGNOSIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1314.2–1315. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4826.

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BackgroundComparative data among rheumatoid arthritis (RA), spondylarthritis (SpA) and psoriatic arthritis (PsA) patients regarding long-term survival of etanercept (ETN) in clinical practice are limited.ObjectivesThe first aim of this study was to analyze the long-term (>3 years) ETN survival comparatively between its three main indications. We also aimed to analyze for predictors of long term ETN survival.MethodsWe analyzed data from the University of Crete Rheumatology Clinic Registry (UCRCR), a single center prospective cohort study. All patients with a diagnosis of RA, SpA or PsA start

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Mori, Minako, Vera Adema, Carmelo Gurnari, et al. "Novel Synthetic Lethal Targets for Myeloid Neoplasms with Loss of Chromosome 7." Blood 138, Supplement 1 (2021): 3346. http://dx.doi.org/10.1182/blood-2021-152974.

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Abstract Loss of chr7 (-7) and partial deletions of its long arm (del7q) are observed in 10% of de novo myeloid neoplasms (MNs), 50% of therapy related MDS, up to 60% of post aplastic anemia MNs and occur frequently as evolution of congenital bone marrow failure syndromes (e.g., GATA2 and SAMD9L deficiency, FA). LOH of one or more chr7 genes has been considered the culprit in the pathogenesis of -7/del7q MNs. In addition to the loss of protective alleles, deletion resulting in haploinsufficiency (HI) of tumor suppressor genes (TSGs) in CDRs might be also a cause of leukemogenic drive behind -7

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O’Brien, Stephen G., François Guilhot, John M. Goldman, et al. "International Randomized Study of Interferon Versus STI571 (IRIS) 7-Year Follow-up: Sustained Survival, Low Rate of Transformation and Increased Rate of Major Molecular Response (MMR) in Patients (pts) with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CMLCP) Treated with Imatinib (IM)." Blood 112, no. 11 (2008): 186. http://dx.doi.org/10.1182/blood.v112.11.186.186.

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Abstract Background: Based on results from the IRIS trial, IM is the standard of care for pts with newly diagnosed CML-CP. This report presents the 7 yr data update of IRIS to assess long term outcome, response rate, and safety in pts on primary IM therapy. Methods: 553 pts were randomly assigned to IM and evaluated for hematologic, cytogenetic and molecular responses, discontinuations/cross-over reasons, event-free survival (EFS), progression to accelerated-phase (AP) or blast crisis (BC) and OS. Events for EFS were defined as the first occurrence of any of the following during treatment: dea

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Komrokji, Rami S., Guillermo Garcia-Manero, Lionel Ades, et al. "An Open-Label, Phase 2, Dose-Finding Study of Sotatercept (ACE-011) in Patients with Low or Intermediate-1 (Int-1)-Risk Myelodysplastic Syndromes (MDS) or Non-Proliferative Chronic Myelomonocytic Leukemia (CMML) and Anemia Requiring Transfusion." Blood 124, no. 21 (2014): 3251. http://dx.doi.org/10.1182/blood.v124.21.3251.3251.

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Abstract Introduction: Anemia, a hallmark of MDS, is challenging to treat, particularly after failure of erythropoiesis-stimulating agents (ESAs). Sotatercept (ACE-011) is a novel and first-in-class activin type IIA receptor fusion protein that acts on late-stage erythropoiesis to increase mature erythrocyte release into the circulation (Carrancio et al. Br J Haematol 2014;165:870-82). Treatment with sotatercept stimulated erythropoiesis and significantly increased hemoglobin (Hb) levels in healthy volunteers (Sherman et al. J Clin Pharmacol 2013;53:1121-30), supporting its clinical developmen

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Thái, Hữu Dũng, та Hoàng Ngô. "Đánh giá kết quả phẫu thuật cắt bán phần thanh quản trên nhẫn kiểu chep điều trị ung thư thanh quản giai đoạn sớm". Vietnam Journal of Otorhinolaryngology - Head and Neck Surgery 68, № 62 (2024): 9–14. http://dx.doi.org/10.60137/tmhvn.v68i62.77.

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Mục tiêu: Nhằm đánh giá kết quả phẫu thuật cắt bán phần thanh quản trên nhẫn kiểu CHEP điều trị ung thư thanh quản giai đoạn sớm. Phương pháp nghiên cứu: Nghiên cứu mô tả hàng loạt ca, với 27 bệnh nhân đã chẩn đoán ung thư thanh quản giai đoạn T1 và T2 được phẫu thuật cắt bán phần thanh quản trên nhẫn kiểu CHEP tại bệnh viện Tai Mũi Họng TP.HCM từ tháng 12/2018 đến tháng 4/2022. Kết quả: Mẫu nghiên cứu có tỉ lệ nam: nữ = 8:1, độ tuổi trung bình là 59.5 ± 6.4 tuổi, thói quen hút thuốc lá chiếm 77.8%, với triệu chứng khàn tiếng trong vòng 3 tháng chiếm 51.8%. Giai đoạn T1 chiếm 85%, N0 chiếm 100

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Cattaneo, Chiara, Roberta Di Blasi, Crisitina Skert, et al. "Bloodstream Infections in Hematological Cancer Patients Colonized By Multiresistant Bacteria: Final Results of a Multicentric Prospective Observational Seifem Study." Blood 128, no. 22 (2016): 3700. http://dx.doi.org/10.1182/blood.v128.22.3700.3700.

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Abstract Introduction. Multiresistant (MR) bacteria colonization is considered predictive of related bloodstream infections (BSI), which are worrisome among hematological patients (pts). Few data are available about the actual incidence of MR colonization and the probability of developing a BSI in this population. A multicentric prospective observational study has been carried out within the SEIFEM group, with the aim of detecting the incidence of MR bacterial colonization and the probability of developing MR BSI in hematological pts. Patients and Methods. Between March 1st and August 31st 201

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Ravindra, Aditya, Luna Acharya, Bradley Loeffler, Sarah L. Bell, Grerk Sutamtewagul, and Prajwal Dhakal. "Abstract 4373: Venetoclax-based therapy in treatment-naïve and relapsed/refractory acute myeloid leukemia." Cancer Research 83, no. 7_Supplement (2023): 4373. http://dx.doi.org/10.1158/1538-7445.am2023-4373.

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Abstract Background: Clinical trials in acute myeloid leukemia (AML) report complete remission (CR) in ~60% of newly diagnosed (ND) pts treated with venetoclax (VEN)-based therapy with hypomethylating agents (HMA, azacitidine [AZA] and decitabine [DEC]) or low-dose cytarabine. However, results from prospective studies in relapsed refractory (R/R) AML remain scarce. Here, we compare the outcomes in ND and R/R pts treated with VEN-based therapy. Methods: We performed a retrospective analysis of ND and R/R pts with AML diagnosed between 2016 and 2021 who were treated with VEN-based therapy at the

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Hansra, Damien Mikael, Amber Moran, Becky Slawik, et al. "Evaluation of pathologic and genomic characteristics in female breast cancer patients." Journal of Clinical Oncology 39, no. 15_suppl (2021): e13001-e13001. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e13001.

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e13001 Background: The genomic landscape of female breast cancer is rapidly evolving partially owing to advancements in next generation sequencing (NGS). Here we report the genomic characteristics of female breast cancer patients with locally recurrent inoperable and metastatic disease. Methods: IRB approval was obtained for a retrospective analysis of archived pathology on patients treated at Cancer Treatment Centers of America. Comprehensive genomic profiling of tumors was derived from Foundation One (F1) and Guardant 360 NGS. Clinical information was derived from retrospective chart review.

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Eriksson, Bengt I., Lars C. Borris, Richard J. Friedman, et al. "Oral Rivaroxaban Compared with Subcutaneous Enoxaparin for Extended Thromboprophylaxis after Total Hip Arthroplasty: The RECORD1 Trial." Blood 110, no. 11 (2007): 6. http://dx.doi.org/10.1182/blood.v110.11.6.6.

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Abstract Background Thromboprophylaxis for at least 10 days and for up to 4–5 weeks is recommended after total hip arthroplasty (THA). Rivaroxaban is an oral, direct Factor Xa inhibitor in advanced clinical development for the prevention and treatment of thromboembolic disorders. RECORD1 was a phase III, multinational, randomized, double-blind, double-dummy trial, conducted to determine the efficacy and safety of oral rivaroxaban, compared with subcutaneous enoxaparin, for 5 weeks of thromboprophylaxis in patients undergoing THA. Methods Patients received rivaroxaban 10 mg beginning 6–8 hours

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Troitskaya, E., S. Velmakin, R. Osipyants, A. Arbuzova, V. R. Espinoza, and Z. Kobalava. "POS0217 PULSE WAVE VELOCITY ELEVATION ABOVE INDIVIDUAL REFERENCE VALUES AND AORTIC-BRACHIAL STIFFNESS MISMATCH AS EARLY MARKERS OF ARTERIAL STIFFNESS INCREASE IN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 326.1–326. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3889.

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Background:Arterial stiffness (AS) is a known predictor of cardiovascular (CV) disease. The measurement of pulse wave velocity (PWV) is considered to be a gold standard of AS assessment but the recommended threshold of 10 m/s1 may not take into account multiple factors influencing PWV. Use of the proposed individual reference values may help to identify patients with AS increase despite PWV level below this threshold2. The impact of AS on CV outcomes may be mediated by the reversal of the aortic-brachial stiffness (AS gradient)3. One small study in patients with type 2 diabetes has shown that

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Tirelli, Valentina, Francesca Masiello, Massimo Sanchez, et al. "Effects of Ontogeny, Ethnicity, Gender and Loss of Companion Cells on Ex-Vivo Expansion of Erythroid Cells for Transfusion." Blood 118, no. 21 (2011): 1261. http://dx.doi.org/10.1182/blood.v118.21.1261.1261.

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Abstract Abstract 1261 The observation that CD34pos and mononuclear cells (MNC) from cord (CB) and adult (AB) blood generate great numbers of erythroid cells (EBs) in human erythroid massive amplification (HEMA) cultures (cultures stimulated with human SCF, IL-3, erythropoietin, dexamethasone and estradiol) led to the hypothesis that EBs generated ex-vivo from currently discarded stem cell sources (low volume CB and MNC from leukoreduced AB) may serve as transfusion products. Studies on ex-vivo EB expansion performed primarily with cells from de-identified Caucasian donors have demonstrated do

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Rashidi, Armin, Suravi Raychaudhuri, Hakan Gem, et al. "Shotgun Sequencing of Multi-Site Oral and Colonic Microbiota in Patients with AML: Site-Specific Patterns and Microbiota Decompartmentalization." Blood 142, Supplement 1 (2023): 2273. http://dx.doi.org/10.1182/blood-2023-185078.

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Gut microbiota is a source of pathogens in immunocompromised patients. While most microbiota studies in patients with AML receiving induction chemotherapy have focused on the gut microbiota, the few on salivary microbiota suggest less severe dysbiosis. As the saliva does not have its own intrinsic microbiota and takes fractions of the microbiota from the different oral tissues it bathes, the extent to which the salivary microbiota reflects microbial changes in other oral sites is unknown. To fill this knowledge gap, we characterized the microbiota in longitudinal salivary, supragingival plaque

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Nazir, Sheraz A., Jamal N. Khan, Islam Z. Mahmoud, et al. "The REFLO-STEMI (REperfusion Facilitated by LOcal adjunctive therapy in ST-Elevation Myocardial Infarction) trial: a randomised controlled trial comparing intracoronary administration of adenosine or sodium nitroprusside with control for attenuation of microvascular obstruction during primary percutaneous coronary intervention." Efficacy and Mechanism Evaluation 3, no. 9 (2016): 1–48. http://dx.doi.org/10.3310/eme03090.

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BackgroundMicrovascular obstruction (MVO) predicts short- and longer-term outcomes following primary percutaneous coronary intervention (PPCI) treatment of ST-elevation myocardial infarction (STEMI). The evidence base supporting the role of adenosine and sodium nitroprusside (SNP), the most evaluated adjunctive therapies aimed at attenuating MVO and infarct size, remains weak as the trials involved have had variable end points and used differing drug doses and modes of delivery.ObjectiveTo determine whether intracoronary administration of adenosine or SNP following thrombus aspiration reduces

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Ahmed, Abdulrahman, Fatima Abacha Ali, Dr Hadiza Yahaya, Dr Abba Jidda, and Mairo Bukar Nbahi. "Evaluating the Influence of Climate Change on Food Security and Nutritional Status among People in Monguno Local Government Area of Borno State, Northeast Nigeria." International Journal of Research and Scientific Innovation XI, no. XI (2024): 689–99. https://doi.org/10.51244/ijrsi.2024.11110055.

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One aspect that poses a threat to the health and wellbeing of human race today is climate change. The impacts of climate change can never be over emphasized, climate change and health are fundamental elements that are surrounded by countless indicators. Climates change without doubt or fear of contradictions remain one of the determinants of health. The human body as a machine must be kept within a narrow physiological limit so also climate are indices that must be observed within an atmospherically friendly manner. This study on Evaluating the influence of climate change on food security and

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Morlà, R., T. LI, G. Luta, and T. Pincus. "AB0786 Self-reported disease burden is greater in spondyloarthritis than in rheumatoid arthritis patients according to multidimensional questionnaire (MDHAQ / RAPID3) scores, despite fewer females, who generally have higher scores on patient questionnaires." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1520.1–1520. http://dx.doi.org/10.1136/annrheumdis-2022-eular.852.

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BackgroundFemale patients generally have higher scores than males on most items on self-report questionnaires, including MDHAQ/RAPID3 (multi-dimensional health assessment questionnaire/routine assessment of patient index data)1. MDHAQ/RAPID3 was validated in patients with rheumatoid arthritis (RA), but is informative in all diseases studied, including spondyloarthritis (SpA)2. More SpA patients are men than RA patients, suggesting lower scores, but MDHAQ scores are higher in SpA than RA.ObjectivesWe compared self-report MDHAQ/RAPID3 scores in RA vs SpA patients according to gender.MethodsPatie

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Korman, Rawan, Dunia Hatabah, Giorgi Maziashvili, et al. "Secretory Phospholipase A2(sPLA2) in Patients with Sickle Cell Disease (SCD) Hospitalized for Vaso-Occlusive Pain Episodes (VOE)." Blood 144, Supplement 1 (2024): 1123. https://doi.org/10.1182/blood-2024-210525.

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Introduction: Acute chest syndrome (ACS) is a leading cause of morbidity and mortality in patients with SCD. Severe ACS often develops during the course of an acute VOE with symptoms ranging from fever and chest pain (CP) to respiratory distress. SPLA2 is a potent inflammatory mediator that is elevated in multiple human chronic diseases such as rheumatoid arthritis, viral and bacterial infections, and septic shock among others. Previous studies in SCD have reported elevated levels of sPLA2 in patients presenting with ACS and suggest a role for sPLA2 in predicting development of ACS. Understand

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delMoral-Diez, Juan J., Elena Juventina Tuna-Aguilar, Alvaro Aguayo, Antonio Olivas-Martinez, and Gladys P. Agreda-Vasquez. "Prognosis in Patients with Human Immunodeficiency Virus Infection and Advanced Clinical Stage Classic Hodgkin's Lymphoma." Blood 134, Supplement_1 (2019): 5281. http://dx.doi.org/10.1182/blood-2019-123792.

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Classic Hodgkin's lymphoma (cHL) represents 95% of all Hodgkin lymphomas, and is responsible of 0.5% of all cancer types (Siegel, Miller & Jemal, 2016). In HIV positive patients, the incidence of cHL is high (5-20 fold). The use of combination antiretroviral therapy (CART) and CD4 count >200 cells/uL appears to increase the risk; nonetheless, the risk for developing cHL in HIV infected patients remains high, regardless of CD4 count. The median patients' age of HIV-associated classic Hodgkin's lymphoma (HIV-cHL) ranges from 40 to 49 years old, slightly higher than the age observed in gen

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Lee, Jong Hyuk, Jae-Ho Yoon, Daehun Kwag, et al. "Incidence and Risk Factors for Central Nervous System Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Acute Lymphoblastic Leukemia." Blood 142, Supplement 1 (2023): 2210. http://dx.doi.org/10.1182/blood-2023-181540.

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Background Acute lymphoblastic leukemia (ALL) is frequently accompanied with the involvement of the central nervous system (CNS). The clinical prognosis for ALL patients with CNS disease is generally unfavorable, and prophylactic measures such as intrathecal chemotherapy are highly recommended. In adult ALL patients, hematopoietic stem cell transplantation (HSCT) presents a potential curative approach. However, there are currently only a few reports available on the risk factors and epidemiology of CNS relapse after HSCT. Method We conducted a retrospective single-center cohort study involving

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Foley, Bree, Michael R. Verneris, Julie Curtsinger та ін. "Natural Killer (NK) Cells Respond to CMV Reactivation After Allogeneic Transplantation with An Increase in NKG2C+CD57+ Self-KIR+ NK Cells with Potent IFNγ Production". Blood 118, № 21 (2011): 356. http://dx.doi.org/10.1182/blood.v118.21.356.356.

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Abstract Abstract 356 In healthy individuals human cytomegalovirus (hCMV) infection is asymptomatic or a mild illness. In immunosuppressed patients after hematopoietic cell transplantation, however, CMV is potentially life-threatening complication. We have previously shown that upon mouse CMV infection, a population of Ly49H+ NK cells expand and are responsible for disease clearance through the induction of a “memory NK cell response”. Whether similar events occur in hCMV infection is unknown. Some studies suggest that the C-type lectin-like receptor NKG2C and the killer cell immunoglobulin-li

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