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Готові списки джерел за темами / 5-(3 Chloro-1-benzothien-2 yl)-4-phenyl-4H-1 / Статті в журналах

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Статті в журналах з теми "5-(3 Chloro-1-benzothien-2 yl)-4-phenyl-4H-1"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Amit, Chattree* and Neelottma Singh. "In-Silico Designing of 5-(3 Chloro-1-Benzothien-2yl)-4-Phenyl-4H-1,2,4 Triazole-3-Thiol derivatives and their Potential application on Fusarium Solani." Journal of Pharma Research 1, no. 2 (2012): 7–10. https://doi.org/10.5281/zenodo.1098653.

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<strong><em>ABSTRACT</em></strong> <em>In silico methods can help in identifying drug targets via bioinformatics tools. The use of computers and computational methods permeates all aspects of drug discovery and forms the core of structure-based drug design. High-performance computing, data management software and internet are facilitating the access of huge amount of data generated and transforming the massive complex biological data into workable knowledge in modern day drug discovery process. In the present work insilico designing of 5-(3 Chloro-1-benzothien-2yl)-4-phenyl-4H-1,2,4 triazole-3

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2

M. Daoud, Khalid, Amal N. Ali, and Amina A. Ahmed. "Synthesis of 2-(3-chloro-4-nitro-1-benzothien-2-yl)-1,3,4-oxadiazole-1,3,4-thiadiazole and 5-(3-chloro-4-nitro-1-benzothien-2-yl)-4H-1,2,4-triazole-3-thiol." JOURNAL OF EDUCATION AND SCIENCE 23, no. 4 (2010): 19–26. http://dx.doi.org/10.33899/edusj.2010.59245.

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3

V, Mujalda, S. Tiwari, V. Sharma, P. Saxena, and M. Shrivastava. "Synthesis of 3-chloro-4- (2-hydroxy-5-(substituted phenyl (diazyl)-N-[(4-oxo-2-phenylquinazoline 3(4H)-yl)]-2-oxoazetidine-1-carbothiamide Analogs as Potential Antimicrobial Agents." International Journal of Drug Design and Discovery 3, no. 2 (2025): 798–802. https://doi.org/10.37285/ijddd.3.2.8.

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Some new series of 3-chloro-4-(2-hydroxy-5-(substituted phenyl (diazyl)-N-[(4-oxo -2-phenylquinazoline 3(4H)-yl)]-2-oxoazetidine-1-carbothiamide have been synthesized by the reaction of 1-[2-hydroxyl–5–(substituted phenyl)diazyl benzylidene-3-(4-oxo-2-phenylquinazolin-3(4H)-yl) thiourea with chloroacetyl chloride and triethyl amine in 1,4 dioxane. The structure of synthesized compounds is confirmed by IR, NMR & Mass spectral studies. The antimicrobial activities of the synthesized compounds were evaluated by screening on different human pathogens using the disc diffusion assay.

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4

Antre, R. V., R. J. Oswal, D. B. Thorat, and R. B. Shete. "Edaravone Part 2: Antibacterial Activity of Novel Substituted Azetidinone Derivatives of Edaravone." International Journal of Drug Design and Discovery 3, no. 2 (2025): 749–52. https://doi.org/10.37285/ijddd.3.2.1.

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This paper describes development of new chemical entities of Edaravone for their antibacterial activity. The chemical name of Edaravone is 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one. Various N-(substituted benzylidenyl)-[2-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)acetohydrazide] (4a-4e) and 2-(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)-acetamide- (3-chloro-4-substituted phenylazetidin-2-one) (DTa-DTe) screened for their antibacterial activity against Escherichia coli and Bacillus subtilis.

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5

CHAUBAN, Vishal, Sbivkanya FULORIA, Neeraj K. FULORIA, Syed R. HASHIM, and Sokindra KUMAR. "SYNTHESIS, CHARACTERIZATION AND COMPARATIVE SCREENING OF SOME NEWER 2-PHENYL INDOLE AND 5-CHLORO-2-PHENYL INDOLE DERIVATIVES." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 20, no. 20 (2012): 69–76. http://dx.doi.org/10.48141/sbjchem.v20.n20.2012.71_revista_2012a.pdf.

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Biologically active phenyl indole and chloro phenyl indole derivatives were efficiently synthesized. The reaction of 2-phenyl-1H-indole A and 5-chloro-2-phenyl-1H-indole B, with chloroacetylchloride yielded 2-chloro-1-(2-phenyl-1H-indol-1-yl)ethanone 1 and 2-chloro-1-(5-chloro-2-phenyl-1H-indol-1-yl)ethanone 4 respectively. Compound 1 and 4 on Friedal Crafts cyclization in presence of aluminium chloride and nitrobenzene yielded indolo[2,1 -alfa]isoquinolin-6(5H)-one 2 and 10-chloroindolo [2,1-alfa]isoquinolin-6(5H)-one 5 respectively, which upon hydrolysis afforded 2-(2-(1H-indol-2-yl)phenyl)a

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6

N. Mousa, Mazin. "EVALUATION OF THE ANTI-INFLAMMATORY ACTIVITY AND ULCEROGENIC LIABILITY OF 5-(3-CHLORO-1-BENZOTHIEN -2-YL)-4-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOL." Basrah Journal of Veterinary Research 11, no. 1 (2012): 122–27. http://dx.doi.org/10.33762/bvetr.2012.54766.

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7

Mistry, Bhavnaben D., Kishor R. Desai, and Nigam J. Desai. "SYNTHESIS, IN VITRO ANTIMICROBIAL ACTIVITY OF SCHIFF’S BASE, AZETIDINONES AND THIAZOLIDINONES." International Journal of Current Pharmaceutical Research 9, no. 1 (2016): 126. http://dx.doi.org/10.22159/ijcpr.2017v9i1.16634.

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Objective: The objective of the present study is to synthesize 3-Chloro-4-[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyrazol-4-yl]-1-(substituted) azetidin-2-one [4a-n] and 2-[3-(2,4-Dichloro-5-fluoro phenyl)-1H-pyraol-4-yl]-3-(substituted phenyl)-1,3-thiazolidin-4-one [5a-n]. The structure of all synthesized compounds were characterized by IR, 1H NMR, 13C NMR and mass spectral studies. Methods: The titled compounds 3-Chloro-4-[3-(2,4-dichloro-5-fluoro phenyl)-1H-pyrazol-4-yl]-1-(substituted) azetidin-2-one [4a-n] and 2-[3-(2,4-Dichloro-5-fluoro phenyl)-1H-pyraol-4-yl]-3-(substituted phenyl)-1,3-thi

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8

Barlin, GB, and C. Jiravinyu. "Potential Antimalarials. XII. 4-Chloro-3-(substituted amino)methyl-5-[7-bromo (and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]biphenyl-2-ols and 4-Chloro-3-(substituted amino)methyl-5-(7-trifluoromethyl-quinazolin-4-ylamino)biphenyl-2-ols." Australian Journal of Chemistry 43, no. 8 (1990): 1367. http://dx.doi.org/10.1071/ch9901367.

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The mono- Mannich bases 3-(t- butylamino )methyl-4?-chloro-, 3-(4- benzylpiperidin-1-yl)methyl-4′-chloro-, 3-(4-benzylpiperazin-1- yl )methyl-4′-chloro-, 4′-chloro-3-diethylaminomethyl-, 4′-chloro-3-(pyrrolidin-1-yl)methyl-, 4′-chloro-3-(piperidin-1-yl)methyl- and 4′-chloro-3-(3- and 4- methylpiperidin-1-yl)methyl-5-[7-bromo (and 7- trifluoromethyl )-1,5-naphthyridin-4-ylamino]- biphenyl-2-ol, and the corresponding substituted 5-(7-trifluoromethylquinazolin-4-ylamino)bi- phenyl-2-ols, have been prepared by condensation of the 5-amino-3-(N- substituted aminomethyl )-4′-chlorobiphenyl-2-ols and

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9

SG, Jawarkar, and Game MD. "Synthesis, Characterization and Antimicrobial Evaluation of New Substituted Thiazolidinones Bearing Triazole Moiety." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 02 (2024): 796–802. http://dx.doi.org/10.25258/ijpqa.15.2.39.

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Series of thiazolidinone derivatives containing triazole moiety have been synthesized by condensing various substituted aldehydes to form Schiff bases which further reacts with thioglycolic acid undergoes ring condensation to form 3-(3-mercapto-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-4-yl)-2-substituted phenylthiazolidin-4-one followed by reaction with ethyl chloroacetate to form ethyl 2-((4-(2-subtituted phenyl-4-oxothiazolidin-3-yl)-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-3-yl)thio)acetate. The synthesized compounds were characterized by elemental analysis, fourier-

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10

Orrego Hernandez, Jessica, Jaime Portilla, Justo Cobo, and Christopher Glidewell. "Two different products from the reaction of 1-aryl-5-chloro-3-methyl-1H-pyrazole-4-carbaldehyde with cyclohexylamine when the aryl substituent is phenyl or pyridin-2-yl: hydrogen-bonded sheetsversusdimers." Acta Crystallographica Section C Structural Chemistry 71, no. 5 (2015): 363–68. http://dx.doi.org/10.1107/s2053229615006403.

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Cyclohexylamine reacts with 5-chloro-3-methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carbaldehyde to give 5-cyclohexylamino-3-methyl-1-(pyridin-2-yl)-1H-pyrazole-4-carbaldehyde, C16H20N4O, (I), formed by nucleophilic substitution, but with 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde the product is (Z)-4-[(cyclohexylamino)methylidene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, C17H21N3O, (II), formed by condensation followed by hydrolysis. Compound (II) crystallizes withZ′ = 2, and in one of the two independent molecular types the cyclohexylamine unit is disordered over two sets of atomic sites

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11

Denislamova, E. S., V. A. Lyadov, D. E. Makrushin, V. G. Ryabov, M. V. Dmitriev, and A. N. Maslivets. "Synthesis of 1-antipyryl-1<i>H</i>-pyrrol-2-ones by interaction <i>N</i>-antipyryl substituted enamines with oxalyl chloride." Журнал органической химии 59, no. 4 (2023): 535–40. http://dx.doi.org/10.31857/s0514749223040122.

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Methyl 4-aryl-2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-ylamino)-4-oxo-2-butenoates react with oxalyl chloride to form methyl 3-aroyl-2-chloro-1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-yl)-4-hydroxy-5-oxo-2, 5-dihydro-1 H -pyrrole-2-carboxylates, which are hydrolyzed to methyl 3-aroyl1-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1 H -pyrazol-4-yl)-2,4-dihydroxy-5-oxo-2,5-dihydro-1 H -pyrrole2-carboxylates, the structure of which was confirmed by X-ray diffraction analysis.

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12

Parmar, M. B., J. H. Pandya, and M. K. Vara. "Synthesis, Characterization of Various Substituted (E)-2-(2-butyl-5-chloro-4-((phenylimino)methyl)-1H-imidazol-1-yl)-N-(4-(3-oxomorpholino) phenyl)acetamide." Journal of Scientific Research 15, no. 2 (2023): 509–18. http://dx.doi.org/10.3329/jsr.v15i2.61736.

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A highly efficient, convergent approach to the synthesis of various substituted (E)-2-(2-butyl-5-chloro-4-((phenylimino)methyl)-1H-imidazol-1-yl)-N-(4-(3-oxomorpholino)phenyl) acetamide analogues is described. Directed vilsmeyer formylation of methyl pentanimidate with glycine provides the key intermediate 2-butyl-5-chloro-1H-imidazole-4- carbaldehyde (INT-01). BCFI (INT-01) is a major active metabolite and the most significant intermediate of Losartan. Therefore, BCFI moiety has scope for good application in medicine. Morpholin-3-one derivative reacts with chloroacetyl chloride in presence of

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13

Journal, Baghdad Science. "Synthesis of some Schiff's bases derivatives from aminoazo compounds." Baghdad Science Journal 4, no. 3 (2007): 416–19. http://dx.doi.org/10.21123/bsj.4.3.416-419.

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Reaction of,2- [( 4- amio phenyl ) diazenyl] 1,3,4- thiadiazole -5- thiol (S1) with p- chlorobenzeldehyde,3,4 – dimethoxy benzaldehyde and pyrrol-2- carbonxaldehyde gave -5- [{4-(4-chlorobenzylidene amino) phenyl} diezenyl]-1,3,4- thiadiazole-2- thiol (S2),5-[{ 4-[(3,4- dimethoxybenzyldene )amino phenyl ] diazenyl)-1,3,4- thiadiazole-2-thiol,(S3) and -5- [4-(1,H – pyrrol -2- yl- methylene)amino phenyl] diazenyl)-1,3,4- thiadiazole-2- thiol (S4) respectively as schiff's bases compounds. On the same route-2-[(4-amino-1- naphthyl ) diazenyl] -1,3,4- thiadiazole -5- thiol (S5) reacts with –p- chlo

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14

Rahman, Mujeeb Ur, Ankita Rathore, Anees A. Siddiqui, Gazala Parveen, and M. Shahar Yar. "Synthesis and Antihypertensive Screening of New Derivatives of Quinazolines Linked with Isoxazole." BioMed Research International 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/739056.

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A series of 7-substituted-3-(4-(3-(4-substitutedphenyl)-4,5-dihydroisoxazol-5-yl)phenyl)-2-substituted quinazolin-4(3H)-one(1–30)have been synthesized by the cyclization of (E)-3-(4-(3-substitutedphenyl)acrylolyl)phenyl)-2-(substitutedphenyl)-7-substituted quinazolin-4-(3H)-one with hydroxylamine hydrochloride. The synthesized compounds were examined for theirin vivoantihypertensive activity using albino rats. All the titled compounds exhibited good to moderate antihypertensive activity. Compounds 7-Chloro-3-(4-(3-(4-chlorophenyl)-4,5- dihydroisoxazol-5-yl)phenyl)-2-p-tolylquinazolin-4(3H)-one

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15

SG, Jawarkar, and Game MD. "Synthesis, Characterization and Antimicrobial Activity of Novel 2-Azetidinones Compounds." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 15, no. 01 (2024): 242–48. http://dx.doi.org/10.25258/ijpqa.15.1.38.

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A series of 2-azetidinone derivatives were synthesized by the formation of triazole, followed by synthesis of Schiff’s bases by condensation of various substituted aldehydes. The Schiff’s bases further reacted to chloroacetyl chloride in the presence of triethyl amine, and undergoes cyclocondensation to give substituted 3-chloro-1-(3-mercapto-5-((5-methoxy-1H-indol-1-yl)methyl)-4H-1,2,4-triazol-4-yl)-4-phenylazetidin-2-one which on further reaction with ethyl chloroacetate, gives substituted ethyl 2-((4-(3-chloro-2-oxo-4-phenylazetidin-1-yl)-3-((5-methoxy-1H-indol-1-yl)methyl)-4,5-dihydro-1H-1

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16

Y., D. KULKARNI, RASHMI SHARMA (Miss), L. SHARMA V, and R. DUA P. "2-Substituted-5-chloro/nitrobenzophenones as Possible Anticonvulsants." Journal of Indian Chemical Society Vol. 64, Jan 1987 (1987): 46–48. https://doi.org/10.5281/zenodo.6196157.

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Department of Chemistry, Lucknow University, Lucknow.-226 007 Pharmacology Division, Central Drug Research Institute, Lucknow-226 001 <em>Manuscript received 8 July 1985, revised 22 May 1986, accepted 26 November 1986</em> Twenty one new 2-(<em>N</em><sup>1</sup>-substituted-phenylthiourea-<em>N<sup>2</sup></em> -y1)/(substituted-phenyl thiocarham ato)/[2-(substituted-phen)limino)thiazolid-4-one-3 yl]/[ (3-merca p to-4-su bstitutedphenyl-1, 2, 4(1)-triazol-5-yl)methylaminolmethyleneoxy]-5-chloro / nitrobenzophenones were synthesised and screened for their acute toxicit

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17

Chaurasia, Sarita, Gaddi Divija, Dyapa Divya, M. Divya, Habeebunnisa ., and Miryanam Harshitha. "Synthesis and characterization of some novel 1,3,4-oxadiazole for anti-inflammatory activity." International Journal of Multidisciplinary Research and Growth Evaluation 4, no. 1 (2023): 365–68. http://dx.doi.org/10.54660/.ijmrge.2023.4.1.365-368.

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A series of five-membered heterocyclic rings were synthesized by the reaction between 2[(4-chlorophenyl) acetyl] benzoic acid and and SOCl2 produced acid chloride and the acid chloride on reaction with substituted aromatic acid to form (3a- 3d) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified by column chromatography. All synthesized derivatives were determined by the carrageenan-induced rat-paw-oedema model for anti-inflammatory

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18

J., A. Patel, D. Mistry B., and R. Desai K. "Synthesis of some novel 4-thiazolidinone compounds and their application as potential antimicrobial agent." Journal of Indian Chemical Society Vol. 83, Oct 2006 (2006): 1041–43. https://doi.org/10.5281/zenodo.5831373.

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Department of Chemistry, B. K. M. Science College, Valsad-396 001, Gujarat, India <em>Manuscript received 14 July 2005, revised 4 January 2006, accepted 28 June 2006</em> 3-Chloro-1-[5' -hydroxy-2' -(phenyldiazenyl) phenyll-4-[2" -hydroxy-5" -(1<em>"' </em>,3<em>'"</em> -benzothiazol-2<em>"'</em> -yl-diazenyl)phenyl)-2-azetidinone (4a-p),3-[5'-hydroxy-2'-(phenyldiazenyl)phenyl]-2-[2" -hydrox)·-5" -(1"' ,3'" -benzothiazol-2"' -yl-diazenyl) phenyl)- 4-thiazolidinone (Sa-p) and 3-[5' -hydroxy-2&#3

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19

Chunduri, Venkata Rao. "Synthesis and Antibacterial Activity of Novel Benzimidazole Linked 1,3,4-Oxadiazole Derivatives." Medicinal Chemistry 9, no. 2 (2019): 6. https://doi.org/10.4172/2161-0444.1000529.

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With an intention to develop potent antimicrobial agents from the source of benzimidazole- 1,3,4-oxadiazole combined heterocyclic derivatives, novel 6-Chloro-2-(2-(5-(substituted phenyl)-1,3,4-oxadiazol-2-yl)ethyl)- 1H-benzo[d]imidazole derivatives were synthesized using condensation reaction of 3-(6-chloro-1H-benzo[d] imidazol-2-yl)propane hydrazide and benzoic acids as key step in presence of POCl3 . All newly synthesized target compounds (4a-4n) were characterized by 1 H NMR, Mass and IR spectral studies and were screened for their antibacterial activity with two bacterial pathogens (Gram p

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20

Youssef, Ahmed Said Ahmed. "Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile and 6-amino-1,4-dihydro-3-methyl-1,4-diphenylpyrano[2,3-c]pyrazole-5-carbonitrile with substituted benzylidenemalononitriles, α,β-acetylenic esters and ketones". Journal of Chemical Research 2009, № 4 (2009): 214–17. http://dx.doi.org/10.3184/030823409x435874.

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Анотація:

Reactions of 2-amino-4,5,6,7-tetrahydro[1]benzothiophene-3-carbonitrile (1a) with substituted benzylidenemalononitriles gave 4-amino-2-(1-cyano-2-arylvinyl)benzothieno[2,3- d]pyrimidine derivatives (3) as ( E,Z)-mixtures and in one case (2c) as separated ( Z)- and ( E)-isomers. Similar treatment of 6-amino-1,4-dihydro-3-methyl-1,4-diphenyl-pyrano[2,3- c]pyrazole-5-carbonitrile (4) yielded similarly-formed pyrazolopyranopyrimidine derivatives (5a, b) as ( Z)-and ( E)-stereoisomers. Attempted acetylation of the aminobenzothienopyrimidines resulted in degradation of the pyrimidine ring and the fo

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21

Patel, Darshana D., and Vikram N. Panchal. "Studies on Metal Complexes of Pyrazole Bearing Ligand with Their Antimicrobial Screening." Oriental Journal Of Chemistry 40, no. 5 (2024): 1394–98. http://dx.doi.org/10.13005/ojc/400522.

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Анотація:

In present research article, we reported the synthesise of novel hetertocyclic ligand namely,5-((3-((1H-benzimidazol-1-yl)methyl)-5-phenyl-1H-pyrazol-1-yl) methyl)-8-hydroxy quinoline (BIPPHQ) from 5-chloro methyl-8-hydroxy quinoline and 1-((5-phenyl-1H-pyrazol-3-yl) methyl)-1H-benzimidazole (BIPP). The BIPP was synthsised by the reaction between hydrazine hydrate with 1-(1H-benzimidazol-1-yl)-4-phenylbut-3-en-2-one (BIPB), which was synthesisd from 1-(1H-benzimidazol-1-yl)propan-2-one (BIP) and benzaldehyde. The transition metal complxes of 5-((3-((1H-benzimidazol-1-yl)methyl)-5-phenyl-1H-pyr

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22

Idrees, M., Y. G. Bodkhe, N. J. Siddiqui, and S. S. Kola. "Synthesis, Characterization and in vitro Antimicrobial Screening of Some Novel Series of 2-Azetidinone Derivatives Integrated with Quinoline, Pyrazole and Benzofuran Moieties." Asian Journal of Chemistry 32, no. 4 (2020): 896–900. http://dx.doi.org/10.14233/ajchem.2020.22490.

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Анотація:

A series of 5-(benzofuran-2-yl)-N-(3-chloro-4-(2-(p-tolyloxy) substituted quinolin-3-yl)-2-oxoazetidin-1-yl)-1-phenyl-1H-pyrazole-3-carboxamide derivatives (4a-f) were synthesized with excellent yields by cyclocondensation reaction of 5-(benzofuran-2-yl)-N′-(2-(p-tolyloxy) substituted quinolin-3-yl)methylene)-1-phenyl-1H-pyrazole-3-carbohydrazide (3a-f) with chloroacetyl chloride in presence of triethylamine in DMF. One pot condensation of 5-(benzofuran-2-yl)-1-phenyl-1H-pyrazole-3-carbohydrazide (1) with 2-(p-tolyloxy) substituted quinoline-3-carbaldehyde (2a-f) in ethanol solvent in presence

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23

Al-Smaisim, Rafah Fadhil. "Synthesis, Characterization and Biological Activity of Some New 4-Substituted-phenyl-3-chloro-1-{5-[(3, 5-dimethyl-1H-pyrazol-1- yl) methyl]-1, 3, 4-thiadiazol-2-yl} azetidin-2-one." Al Mustansiriyah Journal of Pharmaceutical Sciences 12, no. 2 (2012): 123–32. http://dx.doi.org/10.32947/ajps.v12i2.258.

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A new series of 3,5-dimethyl-1H-pyrazole derivatives (1-15) incorporated into fused to different nitrogen and sulphur containing heterocyclic were prepared from 3,5-dimethyl-1H-pyrazole when treated with ethylchloroacetate in the present of potassium carbonate to offer Ethyl (3, 5-dimethyl-1H-pyrazol-1-yl) acetate (1).Compound (1) converted to 2-[(3,5-dimethyl -1H-pyrazol -1-yl) acetyl] hydrazinecarbothioamide (2) by reaction with thiosemicarbazide in methanol.Cyclocondensation (2) was reacted with mineral acid H2SO4 to produce 5-[(3, 5- dimethyl-1H-pyrazol-1-yl) methyl]-1, 3, 4-thiadiazol-2-a

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24

Fuloria, Neeraj Kumar, Vijender Singh, M. Shaharyar, and Mohd Ali. "SYNTHESIS AND ANTIMICROBIAL STUDIES OF NOVEL IMINES AND OXADIAZOLES." SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 16, no. 16 (2008): 11–22. http://dx.doi.org/10.48141/sbjchem.v17.n17.2008.14_2008.pdf.

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N-benzylidene-2-(4-chloro-3-methylphenoxy)acetohydrazides (3a-e), obtained by arylation of 2-(4-chloro-3-methyl phenoxy)acetohydrazide (2), was cyclized with acetic anhydride to yield 1-(5-(( 4-chloro-3-methylphenoxy)methyl)-2-phenyl-l ,3,4-oxadiazol- 3(2H)-yl)ethanones (4a-e). All the newly synthesized compounds were analytically and spectrally characterized and evaluated for anti-bacterial and anti-fungal activities.

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25

Shaik, Afzal, Palleapati Kishor, and Venkata Kancharlapalli. "Synthesis of Novel and Potential Antimicrobial, Antioxidant and Anticancer Chalcones and Dihydropyrazoles Bearing Isoxazole Scaffold." Proceedings 41, no. 1 (2020): 16. http://dx.doi.org/10.3390/ecsoc-23-06476.

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A series of isoxazole based (E)-1-(isoxazole-5-yl)-3-(substituted phenyl)-prop-2-en-1-ones (chalcones, 3a-3o) and 3-(isoxazol-5-yl)-5-(substituted phenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide (dihydropyrazoles, 4a-4o) were synthesized, characterized and evaluated for their antimicrobial, antioxidant and anticancer properties. Chalcones exhibited excellent antibacterial and antioxidant activities whereas the dihydropyrazoles shown superior antifungal and anticancer activities. The compound 3l containing 3,4,5-trimethoxy phenyl ring showed the potent antibacterial activity (MIC = 1 µg/mL) as we

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26

Rakesh, Paliwal, Chandra Sekhar K., Taneja Amit, and K. Mishra S. "Synthesis of substituted 3-chloro-1-(3-(trifluoromethyl)-S-methoxy-4H-1,2,4- triazol-4-yl)-4-phenylazetidin-2-ones." Journal of Indian Chemical Society Vol. 87, May 2010 (2010): 589–93. https://doi.org/10.5281/zenodo.5787989.

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Chemistry Department, Faculty of Science, Narain (P.G.) College, Shikohabad-205 135, Uttar Pradesh, India Manuscript received 15 May "2009, revised 26 August 2009, accepted 28 October 2009 An efficient and extremely fast procedure to synthesize novel biologically active substituted trlnuoro-2-azetldones heterocycles was discussed. Reaction of trifluoroacetic hydrazide 2 with hydrazine hydrate and then cyclization with tetramethoxy methane yields <em>N</em>-(3-(trifluoromethyl)-5-methozy-4<em>H</em>-1,2,4-triazol-4-yl)amine 3. Condensation of the N-(3· (trifluoromethyl)-5-methozy-4<

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27

D.K. Gautam and I. Singh. "A NEW SERIES OF 1,3,4-THIADIAZOLE SUBSTITUTED AZETIDINONE AND THIAZOLIDINONE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY." RASAYAN Journal of Chemistry 17, no. 01 (2024): 176–82. http://dx.doi.org/10.31788/rjc.2024.1718308.

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The new series of 2-({[5-(3-chloro-2-oxo-4-substituted-phenylazetidin-1-yl)-1,3,4-thiadiazol-2- yl]methyl}amino)benzoic acid (13-20) and 2-({[5-(4-oxo-2- substituted-phenyl-1,3-thiazolidin-3-yl)- 1,3,4- thiadiazol-2-yl]methyl}amino)benzoic acid (21-28) have been synthesized from 2-[({5-[(benzylideneamino]- 1,3,4- thiadiazol-2-yl }methyl)amino]-benzoic acid (5-12). All these synthesized compounds were tested for their antimicrobial activity and established by spectroscopic data, and elemental analyses.

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28

Rajput, Chatrasal Singh, and Shiwani Singhal. "Synthesis, Characterization, and Anti-Inflammatory Activity of Newer Quinazolinone Analogs." Journal of Pharmaceutics 2013 (January 17, 2013): 1–7. http://dx.doi.org/10.1155/2013/907525.

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A series of 3-[2′-(Substitutedbenzylideneamino)phenyl]-2-methyl-6-substituted quinazolin-4-ones (5–10), 3-[2′-(3″-chloro-2″-oxo-4″-substitutedphenylazetidin-1″-yl)phenyl]-2-methyl-6-substitutedquinazolin-4-ones (11–16), and 3-[2′-(2″-substitutedphenyl-4″-oxo-1″,3″-thiazolidin-3″-yl)phentl]-2-methyl-6-substitutedquinazolin-4-ones (17–22) have been synthesized in the present study. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, H1 NMR, and mass spectral data. All the newly synthesized compounds were screened for anti-inflammatory and analgesic a

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29

Zadrazilova, Iveta, Sarka Pospisilova, Karel Pauk, et al. "In VitroBactericidal Activity of 4- and 5-Chloro-2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides against MRSA." BioMed Research International 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/349534.

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A series of nine substituted 2-hydroxy-N-[1-oxo-1-(phenylamino)alkan-2-yl]benzamides was assessed as prospective bactericidal agents against three clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) andS. aureusATCC 29213 as the reference and quality control strain. The minimum bactericidal concentration was determined by subculturing aliquots from MIC determination onto substance-free agar plates. The bactericidal kinetics of compounds 5-chloro-2-hydroxy-N-[(2S)-3-methyl-1-oxo-1-{[4-(trifluoromethyl)phenyl]amino}butan-2-yl]benzamide (1f),N-{(2S)-1-[(4-bromophenyl)amino]-3-me

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30

Kaushik, Darpan, and Namita Maan. "N-[1-(1H-Benzimidazol-2-yl)-2-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)vinyl]benzamide." Molbank 2011, no. 3 (2011): M731. http://dx.doi.org/10.3390/m731.

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31

Shailesh, H. Shah, and S. Patel Pankaj. "Synthesis and antimicrobial activity of azetidin-2-one containing pyrazoline derivatives." Journal of Indian Chemical Society Vol. 90, Jun 2013 (2013): 863–66. https://doi.org/10.5281/zenodo.5773732.

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Department of Chemistry, Patel J.B.R. Arts, Patel A.M.R. Commerce & Patel J.D.K.D. Science College, Borsad-388 540, Gujarat, India <em>E-mail </em>: shailchem@yahoo.com Department of Chemistry, Sheth L.H. Science College, Mansa, Gujarat, India <em>Manuscript received online 25 July 2012, revised 26 July 2012, accepted 31 July 2012</em> Pyrazolines are well-known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. A new series of 3-chloro-1-{ 4-[5-(substituted phenyl)-4,5-dihydropyrazol-3-yl]phenyl}-4-(4-choloroph

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32

Fuerst, E. Patrick, Charles J. Arntzen, Klaus Pfister, and Donald Penner. "Herbicide Cross-Resistance in Triazine-Resistant Biotypes of Four Species." Weed Science 34, no. 3 (1986): 344–53. http://dx.doi.org/10.1017/s0043174500066960.

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The cross-resistance of triazine-resistant biotypes of smooth pigweed (Amaranthus hybridusL. # AMACH), common lambsquarters (Chenopodium albumL. # CHEAL), common groundsel (Senecio vulgarisL. # SENVU), and the crop canola (Brassica napusL. var. Atratower) to a selection of herbicides was evaluated at both the whole plant and chloroplast level. The triazine-resistant biotypes of all four species showed a similar pattern of cross-resistance, suggesting that a similar mutation had occurred in each species. The four triazine-resistant biotypes were resistant to injury from atrazine [6-chloro-N-eth

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33

Kaushik, Darpan, Tarawanti Verma, and Kapish Madaan. "2-(Benzoylamino)-3-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)acrylic acid." Molbank 2011, no. 2 (2011): M726. http://dx.doi.org/10.3390/m726.

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34

M'hamedi, Ahmed, and Andrei S. Batsanov. "Phosphorescent mono- and diiridium(III) complexes cyclometalated by fluorenyl- or phenyl-pyridino ligands with bulky substituents, as prospective OLED dopants." Acta Crystallographica Section E Crystallographic Communications 76, no. 3 (2020): 392–99. http://dx.doi.org/10.1107/s2056989020001784.

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The crystal structures of tris[9,9-dihexyl-2-(5-methoxypyridin-2-yl-κN)-9H-fluoren-3-yl-κC 3]iridium pentane monosolvate, [Ir(C31H38NO)3]·C5H12, (I), di-μ2-chlorido-bis{bis[2-(5-fluoropyridin-2-yl)-9,9-dihexyl-9H-fluoren-3-yl]iridium} pentane 0.3-solvate, [Ir2(C30H35FN)4Cl2]·0.3C5H12, (II), di-μ2-cyanato-bis{bis[9,9-dihexyl-2-(5-methoxypyridin-2-yl)-9H-fluoren-1-yl]iridium} pentane monosolvate, [Ir2(C31H38NO)4(NCO)2(NCO)2]·C5H12, (III), and {μ-N,N′-bis[3,5-bis(trifluoromethyl)phenyl]oxamidato}bis(bis{2-[4-(2,4,6-trimethylphenyl)pyridin-2-yl]phenyl-κ2 C 1,N′}iridium)–chlorobenzene–pentane (1/2.

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35

Safonov, A. A. "Synthesis, physico-chemical properties of 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohyd-razides." Farmatsevtychnyi zhurnal, no. 5 (August 14, 2018): 31–36. http://dx.doi.org/10.32352/0367-3057.5.16.03.

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The value of the class of 1,2,4-triazole derivatives to create a low-toxic and highly active substances is huge. There are a lot of facts about the high biological activity among a number of substances. The 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazides derivatives causes of particular interest in this direction. The aim of the work was to synthesize 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3-yl)thio)acetohydrazides and their derivatives, studying of their physico-chemical properties. 2-((4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazol-3

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36

Goswami, K. V., S. P. Vyas, K. P. Damor, Kokila A. Parmar, and Sarju N. Parajapati. "EFFICIENT SYNTHESIS OF 2-AMINO-4-(2-CHLORO-5-(4- SUBSTITUTEDPHENYL) PYRIDIN-3-YL)-1-(4-SUBSTITUTED PHENYL)-7,7-DISUBSTITUTED-5-OXO-1,4,5,6,7,8- HEXAHYDROQUINOLINE-3-CARBONITRILE DERIVATIVES AND THEIR MICROBIAL SCREENING." RASAYAN Journal of Chemistry 15, no. 02 (2022): 1095–101. http://dx.doi.org/10.31788/rjc.2022.1526848.

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The work reports derivatives of 2-amino-4-(2-chloro-5-(4-substituted phenyl) pyridine-3-yl)-1-(4- substitutedphenyl)-7,7-disubstituted-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile Q(1-14) have been synthesized by the reaction of 5,5-disubstituted-1, 3-cyclohexanedione and 4- substituted aniline in the presence of ethanol and piperidine. The structure of synthesized compounds is characterized by spectroscopic methods suchas IR, 1H NMR, Mass Spectroscopy, and elemental analysis. The efficient novel derivativesQ(1-14) with different effective substituent (-CH3, -NO2, -OCH3 , -Br) was scree

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37

Fun, Hoong-Kun, Ching Kheng Quah, S. Sarveswari, V. Vijayakumar, and R. Prasath. "6-Chloro-2-methyl-4-phenyl-3-[1-phenyl-5-(2-thienyl)-4,5-dihydro-1H-pyrazol-3-yl]quinoline." Acta Crystallographica Section E Structure Reports Online 65, no. 11 (2009): o2707—o2708. http://dx.doi.org/10.1107/s1600536809040239.

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38

RAKESH, KUMAR, GIRl S., and NIZAMUDDIN. "Synthesis of some 1-[5' (Substituted-phenoxymethyl)- 1', 3',4'-thiadiazol-2'-yl]-4-substituted-2-azetidinones as Potential Fungicides." Journal of Indian Chemical Society Vol. 65, Aug 1988 (1988): 571–73. https://doi.org/10.5281/zenodo.6043518.

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Chemistry Department, University of Gorakhpur, Gorakhpur-273 009 <em>Manuscript received 22 February 1988, accepted 28 May 1988</em> Several 1-(5<em>'</em>-substituted-phenyl-1<em>'</em>,3<em>'</em>,4<em>'</em>-thiadiazol-2<em><sup>'</sup></em>-yl)-3-chloro-4-substituted-2- azetidinones have been synthesised by the annulation of acid chlorides on anils using Et, N, and their antifungal activities have been reported. Based on screening data attempt has been made to throw light on structure-activity relationship

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39

Kumar, H. Vijay, C. R. Gnanendra, and Nagaraja Naik. "Synthesis of Amino Acid Analogues of 5H-Dibenz[b,f]azepine and Evaluation of their Radical Scavenging Activity." E-Journal of Chemistry 6, no. 1 (2009): 125–32. http://dx.doi.org/10.1155/2009/361490.

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A method for the synthesis of tyrosine, phenyl alanine, hydroxy proline and threonine free amino acid analogues of 5H-dibenz[b,f]azepine is proposed. 5H-dibenz[b,f]azepine was prepared by known method. The key intermediate 3-chloro-1-(5H-dibenz[b,f]azepine-5-yl)propan-1-one was obtained byN-acylation of 5H-dibenz[b,f]azepine with 3-chloro propionyl chloride. Further coupling of respective free amino acid to produce 2-(3-(5H-dibenz[b,f]azepine-5-yl)-3-oxopropylamino)3-(4 hydroxyphenyl) propanoic acid, 2-(3-(5H-dibenz[b,f]azepine-5-yl)-3-oxopropylamino)-3-phenyl propanoicacid,1-(3-(5H-dibenz[b,f

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40

K., D. Patel, D. Mistry B., and R. Desai K. "Synthesis and biological screening of new 2-azetidinones and 4-thiazolidinones." Journal of India Chemical Society Vol 81, Sep 2004 (2004): 783–85. https://doi.org/10.5281/zenodo.5833180.

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Department of Chemistry, B. K. M. Science College, Valsad-396 001, India Department of Chemistry, South Gujarat University, Surat-395 007, India <em>Manuscript received 11 February 2003, revised 15 September 2003, accepted 6 April 2004</em> 4-Aryl-1-[2'-(2",4" ,6" -trichlorophenoxymethyl)-1' ,3' ,4' -thiadiazol-51 -yl)-3-chloro-2-azetidinone (4a-j) and 2- phenyl-3-[2'- (2" ,4" ,6" -trichlorophenoxymethyl)-11 ,31 ,41 -thiadiazol-5' -yl]-5-substituted-4-thiazolidinone (5a-j) have been synthesized from their Schiff bases (3a-j). They have been

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41

Verma, Tarawanti, Manish Sinha, and Nitin Bansal. "Synthesis of Novel 1,2-Dihydro-1,2,4-Triazin-6(5H)-one Derivatives as Anticancer Agents." Current Bioactive Compounds 16, no. 7 (2020): 1116–31. http://dx.doi.org/10.2174/1573407215666191022123310.

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Introduction: Cancer is still an untreatable disease and the second leading cause of death globally. The heterocyclic compounds have always played a major role in the anticancer drug discovery program. 1,2,4-Triazine-6-ones is a heterocyclic privileged structure with diversified activities. In the presented study, 21 novel 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6 (5H)-one derivatives (13(a-k), 18(a-j) and 21(a1-a4, b)) have been synthesized and tested for their anticancer activity. Methods: The 2,5-disubstituted-3-phenyl-1,2-dihydro-1,2,4-triazin-6(5H)-one derivatives (13(a-k), 1

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42

Driver, Tony, and Lawrence R. Oliver. "Control of Woolly Croton (Croton capitatus) in Soybean (Glycine max)." Weed Science 33, no. 5 (1985): 727–29. http://dx.doi.org/10.1017/s0043174500083181.

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Field studies were conducted in 1981 to 1983 to evaluate selected herbicides for control of a natural infestation of woolly croton (Croton capitatusMichx. ♯ CVNCP) in soybean [Glycine max(L.) Merr.]. Ineffective woolly croton control was obtained with all preemergence herbicides evaluated. Early postemergence treatments of acifluorfen {5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoic acid} and lactofen {1-(carboethoxy)ethyl) 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate} provided excellent woolly croton control. Postdirected applications of oxyfluorfen [2-chloro-1-(3-ethoxy-4-n

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43

Salahuddin, Md, Sunil Kakad, and S. M. Shantakumar. "Synthesis of Some Novel Thieno[2, 3-d] pyrimidines and their Antibacterial Activity." E-Journal of Chemistry 6, no. 3 (2009): 801–8. http://dx.doi.org/10.1155/2009/361282.

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Bromination of intermediate 1-[4-(6, 7-dihydro-5H-cyclopenta [4, 5] thieno[2, 3-d]pyrimidin-4-yl amino) phenyl] ethanone(4)yielded(5). Which upon reaction with different substituted benzothiazoles give a novel series of pyrimidine[6(a-g)]. However reaction of(5)with 4-chloro-2-triflouro acetyl aniline provided(6h). Similarly reaction of(5)with 5-amino tetrazole & 2-amino benzimidazole produced(6i)&(6j)respectively. All the synthesized compounds were tested against bacteria (Gram positive and Gram negative).

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44

Das, Rina, and Dinesh Kumar Mehta. "Evaluation and Docking Study of Pyrazine Containing 1, 3, 4-Oxadiazoles Clubbed with Substituted Azetidin-2-one: A New Class of Potential Antimicrobial and Antitubercular." Drug Research 71, no. 01 (2020): 26–35. http://dx.doi.org/10.1055/a-1252-2378.

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Abstract Background Tuberculosis (TB) caused by Mycobacterium tuberculosis is one of the main killers of people all over the world. The major hurdles with existing therapy are the lengthy regimen and appearance of multi drug resistant (MDR) and extensively drug resistant (XDR) strains of M.tuberculosis. Aims The present work was aimed to synthesize and determine antitubercular and antimicrobial potential of some novel 3-chloro-4-aryl-1-[4-(5-pyrazin-2-yl[1,3,4]oxadiazole-2-ylmethoxy)-phenyl]-azetidin-2-one derivatives 7(a-h) from pyrazinoic acid as precursor, which is a well-established antitu

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45

Saddam Fandi Al-Mathkuri, Tahseen, Hamid Mohammed Saleh Al-Jubori, and Ali Taha Saleh. "Synthesis and Study the Chelating Activity of some Polymers Containing Heterocyclic Rings, The Derivatives from 1,2,4- trizol Levofloxacin acid." Oriental Journal of Chemistry 34, no. 4 (2018): 2031–42. http://dx.doi.org/10.13005/ojc/3404042.

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The compound 6-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-7H-[1,4] oxazino[2,3,4-ij] quinolin-7-one (M1) synthesize from the reaction of thiocarbohydrazide with levofloxacin acid by using ethanol as a solvent, phenolic Schiff bases (Z)-9-fluoro-6-(4-((4-hydroxybenzylidene) amino)-5-mercapto4H1,2,4-triazol-3-yl)-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij] quinolin-7-one (M2), (Z)-6-(4-((2,4-dihydroxybenzylidene) amino)-5-mercapto-4H-1,2,4-triazol-3-yl)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-2,3-dihydro-

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46

Krstulović, Luka, Katarina Mišković Špoljarić, Vesna Rastija, Nikolina Filipović, Miroslav Bajić, and Ljubica Glavaš-Obrovac. "Novel 1,2,3-Triazole-Containing Quinoline–Benzimidazole Hybrids: Synthesis, Antiproliferative Activity, In Silico ADME Predictions, and Docking." Molecules 28, no. 19 (2023): 6950. http://dx.doi.org/10.3390/molecules28196950.

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The newly synthesized quinoline–benzimidazole hybrids containing two types of triazole-methyl-phenoxy linkers were characterized via NMR and elemental analysis. Additional derivatization was achieved by introducing bromine at the C-2 position of the phenoxy core. These novel hybrids were tested for their effects on the growth of the non-tumor cell line MRC-5 (human fetal lung fibroblasts), leukemia and lymphoma cell lines: Hut78, THP-1 and HL-60, and carcinoma cell lines: HeLa and CaCo-2. The results obtained, presented as the concentration that achieves 50% inhibition of cell growth (IC50 val

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47

Abouzied, Amr S., Jehan Y. Al-Humaidi, Abdulrahman S. Bazaid, et al. "Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety." Molecules 27, no. 19 (2022): 6368. http://dx.doi.org/10.3390/molecules27196368.

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Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity. The starting 1-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-3-phenylthiourea (2) was prepared and reacted with various hydrazonoyl halides 3a–h, α-haloketones 5a–d, 3-chloropentane-2,4-dione 7a and ethyl 2-chloro-3-oxobutanoate 7b, which afforded the 3-aryl-5-substituted 1,3,4-thiadiazoles 4a–h, 3-phenyl-4-arylthiazoles 6a–d and the 4-methyl-3- phenyl

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48

Loh, Wan-Sin, Hoong-Kun Fun, S. Sarveswari, V. Vijayakumar, and B. Palakshi Reddy. "6-Chloro-3-[5-(4-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2-methyl-4-phenylquinoline." Acta Crystallographica Section E Structure Reports Online 66, no. 2 (2010): o304. http://dx.doi.org/10.1107/s1600536810000218.

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49

Choi, Won-Sik, Seok-Woo Nam, Il-Doo Kim, et al. "Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives." Journal of Chemistry 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/241793.

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Pesticidal activities of 4-[5-(2-cyclopropylaminopyrimidin-4-yl)-4-(4-chloro-2-fluoro-phenyl)thiazol-2-yl]-1-methylpiperidine, designated as Comp I, have been determined against a mosquito larva,Culex pipiens pallens, and a phytopathogenic fungus,Phytophthora capsici. Comp I was used as the leading compound in this study. The compounds were synthesized by reacting them with two functional groups, 3-thiophenyl and 2-thiophenyl groups, instead of 4-chloro-2-fluorophenyl group in Comp I. Other functional groups such as 2-aminothiazole, 2-(1-methylpiperazin-4-yl)thiazole, and 2-(piperazin-4-yl)thi

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Jenan, Mohammed Ubaid, Fauzi Al-Rubaye Abeer, and Hadi Hameed Imad. "Analysis of Bioactive Chemical Compounds of Trogoderma granarium (Insecta: Coleoptera: Dermestidae) Using Gas Chromatography – Mass Spectrometry." International Journal of Toxicological and Pharmacological Research 9, no. 3 (2017): 199–205. https://doi.org/10.5281/zenodo.12698026.

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Methanolic extract of bioactive compounds of <em>Trogoderma granarium</em> was assayed. GC-MS analysis of <em>Trogoderma granarium</em> revealed the existence of the Pentanoic acid , 1,1-dimethylpropyl ester , (1H)-Pyrimidinone , 5-chloro-4,6-diphenyl, Cyclobutanemethanol , α-methyl- , Nitro-2-methyl-1,3-propanediol , Hydroxylamine ,O-(2-methylpropyl)- , Uridine , 2′,3′-O-(phenylmethylene)- ,Acetic acid ,2-benzoylthio-,2-oxo-2-phenylethyl ester , methylpropyl)- , Uridine , 2′,3′-O-(phenylmethylene)- , 5′-(4-methylbenzenesulfo , Indolinol

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