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Добірка наукової літератури з теми "613.704 46"

Автор: Grafiati

Опубліковано: 15 червня 2022

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Статті в журналах з теми "613.704 46":

Yang, Kaixuan, Jian Wang, Jianli Miao, Jian Zhang, and Fujun Zhang. "All-polymer photodetectors with photomultiplication." Journal of Materials Chemistry C 7, no. 31 (2019): 9633–40. http://dx.doi.org/10.1039/c9tc02751c.

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Photomultiplication type all-polymer photodetectors were fabricated with P3HT : PZ1 (100 : 4, wt/wt) as active layers. The EQE values are 46 700% and 31 700% at 375 nm and 615 nm under a −20 V bias, respectively.

WIESE, KURT L., and E. ROGER JACKSON. "Changes in Calculated Process Times and Drained Weight based on Soaking and Blanching of Kidney and Navy Beans." Journal of Food Protection 56, no. 3 (March 1, 1993): 239–42. http://dx.doi.org/10.4315/0362-028x-56.3.239.

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Kidney and navy beans were given different soaking/blanching treatments and canned in 300 × 407 and 603 × 700 cans with each container receiving equal amounts of dry weight of that bean. The process time (Bb) for kidney beans decreased as the amount of moisture in the beans increased. For both kidney and navy beans soaked for 2 h, the process time decreased when the fill weight was increased by 12 and 8%, respectively. For 0 and 2 h soaked kidney beans, the drained weights after processing were statistically the same even though the kidney beans soaked for 2 h had a moisture level 3.3-fold greater. Comparing 2 h soaked beans with fully soaked, blanched beans, the process time increased significantly for fully soaked, blanched beans by 9 and 46% for beans in 300 × 407 can and 603 × 700 can, respectively. The operation of blanching tended to lower the process time and drained weight of navy beans.

Waller, Sophie E., Jeffrey Blackie, and Himanshu Goel. "053 GLUT-1 deficiency presenting as dopa-responsive dystonia: an atypical phenotype of a rare disease." Journal of Neurology, Neurosurgery & Psychiatry 90, e7 (July 2019): A17.2—A17. http://dx.doi.org/10.1136/jnnp-2019-anzan.46.

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IntroductionThe SLC2A1 gene encodes the glucose transporter GLUT1, responsible for normal glucose transport across the blood-brain barrier. Mutations in this gene have classically been associated with an epileptic encephalopathy referred to as GLUT-1 Deficiency Syndrome, which typically presents with early-onset refractory epilepsy, developmental delay and complex movement disorders.1 2 More recently, SLC2A1 variants have been identified in patients with paroxysmal exercise-induced dyskinesia (PED), with or without a history of epilepsy.3 4 Response to medication is typically poor; however, both seizures and dyskinesia may improve following implementation of a ketogenic diet.5 A single case of levodopa responsiveness has previously been described in a subject with SLC2A1 mutation and PED.5Methods and resultsWe describe a 47-year-old female with mild intellectual disability since childhood but no history of epilepsy, who developed episodic dystonia affecting the lower limbs in her early 20’s. A clinical diagnosis of dopa-responsive dystonia was made following a marked, sustained response to levodopa. There was no significant family history. In her 40’s she developed breakthrough dystonia with exertion and choreiform movements affecting the fingers and face. A subsequent dystonia panel identified a heterozygous variant c.[1199G>T];[=] (p.Arg400Leu) in the SLC2A1 gene. Cerebrospinal fluid glucose concentration was low (2.0 mmol/L). She declined a trial of a ketogenic diet.SLC2A1 variants are associated with PED; however, response to levodopa has not been widely reported.ConclusionIt is becoming increasingly evident that the phenotypic presentations of GLUT1 deficiency are diverse, and SLC2A1 testing should be considered in a broader range of patients.ReferencesWang, D, Kranz-Eble P, De Vivo DK. Mutational analysis of GLUT1 (SLC2A1) in Glut-1 Deficiency Syndrome. Human Mutation 2001;16:224–231.Klepper J, Leiendecker B. GLUT1 deficiency syndrome – 2007 update. Developmental Medicine & Child Neurology 2007;49:707–716.Schneider SA, Paisan-Ruiz C, Garcia-Gorostiaga I, Quinn NP, Weber YG, et al. GLUT1 gene mutations cause sporadic paroxysmal exercise-induced dyskinesias. Mov Disord 2009;24(11):1684–1696.Suls A, Dedeken P, Goffin K, Van Esch H, Dupont P. Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, endoding the glucose transporter GLUT1. Brain 2008;131:1831–1844.Baschieri F, Batla A, Erro R, Ganos C, Cordivari C, Bhatia KP. Paroxysmal exercise-induced dystonia due to GLUT-1 mutation can be responsive to levodopa: a case report. J Neurol 2014;261:615–616.

Listyasari, Nurin Aisyiyah, Ardy Santosa, Achmad Zulfa Juniarto, and Sultana MH Faradz. "Multidisciplinary Management of Disorders of Sex Development in Indonesia, A Prototype in Developing Country." Journal of Biomedicine and Translational Research 3, no. 1 (June 23, 2017): 17. http://dx.doi.org/10.14710/jbtr.v3i1.1209.

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Background : Disorder of sex development (DSD) patients require comprehensive management to improve quality of life. A standardized management protocol for patients in Indonesia is not yet available resulting in patients infrequently received a proper diagnosis. This study reported a multidisciplinary management DSD in Indonesia based on minimal diagnostic facilities and expertise in developing country.Objectives : The purpose of the study is to review the management of DSD patients in Indonesia relates to providing appropriate gender assignment and to improving patients quality of life.Methodology : We analyzed the records of DSD patient admitted to the division of Human Genetics Center for Biomedical Research (CEBIOR) Faculty of Medicine Diponegoro University, Semarang, Indonesia from May 2004 - December 2015. Data were collected and analyzed for physical examination, family pedigree karyotyping, hormonal assays and psychosocial. Other examination such as ultrasonography, Xray and Cytoscopy were also recorded for selected cases. Bimonthly, Sexual Adjustment Team (SAT) meeting was recorded.Results : From the total 617 DSD cases we found 426 cases (69,04 %) with 46, XY DSD, 117 cases (18,96%) with 46,XX DSD and 74 cases (12%) with sex chromosome DSD. Most of the patients in the group of 46, XY DSD are Unknown Male Undervirilization (UMU) with 256 cases (60.09%). As the majority cases of 46, XX DSD was Congenital Adrenal Hyperplasia with 81 cases (69.23%). The remaining cases were Androgen Action Disorder (AAD) with 140 cases (32.86%), 46, XY DSD Gonadal Dysgenesis with 30 cases (7.04%), Androgen Excess Disorders with 3 cases (2.56%), Defect of Mullerian Development with 19 cases (16,24%), 3 cases (2.56%) of Androgen Excess and 3 cases (2.56%) of 46, XX Gonadal Dysgenesis.Conclusion : Comprehensive management for DSD Patients help patient in diagnosis, gender assignment and support patient to improve quality of life. This multidisciplinary of DSD team is the only team in Indonesia that can be used as a model for other center in Indonesia as well as other developing countries with minimal diagnostic facilities.

Híjar, Martha, Ricardo Pérez-Núñez, Elisa Hidalgo-Solórzano, Bernardo Hernández Prado, Rosario Valdez-Santiago, Erin B. Hamilton, Spencer L. James, et al. "Unintentional injuries in Mexico, 1990–2017: findings from the Global Burden of Disease Study 2017." Injury Prevention 26, Supp 1 (April 1, 2020): i154—i161. http://dx.doi.org/10.1136/injuryprev-2019-043532.

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BackgroundTo date, the burden of injury in Mexico has not been comprehensively assessed using recent advances in population health research, including those in the Global Burden of Disease Study 2017 (GBD 2017).MethodsWe used GBD 2017 for burden of unintentional injury estimates, including transport injuries, for Mexico and each state in Mexico from 1990 to 2017. We examined subnational variation, age patterns, sex differences and time trends for all injury burden metrics.ResultsUnintentional injury deaths in Mexico decreased from 45 363 deaths (44 662 to 46 038) in 1990 to 42 702 (41 439 to 43 745) in 2017, while age-standardised mortality rates decreased from 65.2 (64.4 to 66.1) in 1990 to 35.1 (34.1 to 36.0) per 100 000 in 2017. In terms of non-fatal outcomes, there were 3 120 211 (2 879 993 to 3 377 945) new injury cases in 1990, which increased to 5 234 214 (4 812 615 to 5 701 669) new cases of injury in 2017. We estimated 2 761 957 (2 676 267 to 2 859 777) disability-adjusted life years (DALYs) due to injuries in Mexico in 1990 compared with 2 376 952 (2 224 588 to 2 551 004) DALYs in 2017. We found subnational variation in health loss across Mexico’s states, including concentrated burden in Tabasco, Chihuahua and Zacatecas.ConclusionsIn Mexico, from 1990 to 2017, mortality due to unintentional injuries has decreased, while non-fatal incident cases have increased. However, unintentional injuries continue to cause considerable mortality and morbidity, with patterns that vary by state, age, sex and year. Future research should focus on targeted interventions to decrease injury burden in high-risk populations.

Doré, M., S. I. Simon, B. J. Hughes, M. L. Entman, and C. W. Smith. "P-selectin- and CD18-mediated Recruitment of Canine Neutrophils under Conditions of Shear Stress." Veterinary Pathology 32, no. 3 (May 1995): 258–68. http://dx.doi.org/10.1177/030098589503200307.

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Neutrophil mobilization at sites of inflammation or thrombosis involves the participation of several adhesion molecules expressed on neutrophils and vascular endothelial cells. Local vascular damage with disruption of the endothelium results in adhesion of platelets to the exposed subendothelium, and these platelets could also participate in neutrophil recruitment. This initial phase of mobilization could be followed by heterotypic aggregation to recruit more leukocytes in the area. The present study first examined the interactions of adherent canine platelets and flowing canine neutrophils using an in vitro system that simulates vascular flow conditions. Results showed that collagen-adherent platelets express the adhesion molecule P-selectin on their surface and can support neutrophil arrest (612 ± 43 neutrophils/mm2) at shear stresses of approximately 2.5 dynes/cm2. Both transient adhesion (manifested by a rolling-type behavior) and complete arrest were observed. These interactions could be totally inhibited by a monoclonal antibody directed against platelet P-selectin (24 ± 18 neutrophils/mm2) but not by a monoclonal antibody against neutrophil CD18 (625 ± 46 neutrophils/mm2). Additionally, under shear mixing conditions (700 RPM), canine blood leukocytes exhibited aggregation (>80% singlets recruited into aggregates after 5 minutes), and this process does not involve P-selectin but is dependent on the neutrophil integrin CD 18. However, stimulation of the blood with platelet-activating factor (5-20 ng/ml) induced a rapid aggregation with a significantly greater number of aggregates when compared with stirring alone (68.3% ± 3.2% versus 35.2% ± 6.3% at 1 minute, P < 0.05), and this aggregation was both P-selectin and CD 18 dependent. Overall, these two mechanisms of leukocyte recruitment (neutrophil arrest on adherent platelets and aggregation) could act sequentially and in a cooperative manner to bring into close contact platelets and neutrophils at sites of inflammation and thrombosis in pathologic conditions in the dog.

Bracarda, Sergio, Roberto Iacovelli, Mimma Rizzo, Marta Rossi, Luca Galli, Giuseppe Procopio, Flavia Longo, et al. "Retrospective observational study of sunitinib administered on schedule 2/1 in patients with metastatic renal cell carcinoma (mRCC): The rainbow study." Journal of Clinical Oncology 32, no. 4_suppl (February 1, 2014): 471. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.471.

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471 Background: Sunitinib is a standard of care in first line mRCC; however, an increasing percentage of treatment-related adverse events are observed in the last 2 treatment weeks of the standard schedule 4/2 (4-weeks-on/2-weeks-off). In a multicenter, retrospective study, we evaluated the efficacy and safety of a modified 2/1 schedule (2-weeks-on/1-week-off), largely used in Italy based on a favorable initial experience. Methods: Data from all consecutive patients (pts) treated in 24 Italian centers with sunitinib on schedule 2/1 were analyzed according to the following groups: Group A, pts moved to schedule 2/1 because of treatment-related toxicities during initial therapy using schedule 4/2; Group B, pts treated ab initio with schedule 2/1, mainly because of poorer clinical conditions. A small group of pts treated with schedule 4/2 served as a control (Group C). Results: 276 consecutive pts treated from November 2005 to August 2013 were analyzed, including 249 treated with schedule 2/1 (Group A, n=208; Group B, n=41; respectively, median age 62 and 61 years; clear cell 94.7% and 87.8%; MSKCC good/intermediate/poor 47.1%/46.6%/6.3% and 36.5%/53.7%/9.8%; brain metastases 3.8% and 9.8%) and 27 pts in Group C (median age 59 years; clear cell 96.3%; MSKCC good/intermediate/poor 22.2%/70.4%/7.4%; no brain metastases). In Group A, the median treatment duration (TD) was 28.2 months (m) (with a median of 4.3 on the initial schedule 4/2 and 19.7 on the following schedule 2/1); median progression-free survival (PFS) was 38.6 m (95% CI, 24.0-58.6). In Group B (with less clear cell cases and more pts of intermediate risk or with brain metastases) median TD was 7.8 m and median PFS was 9.6 m (95% CI, 6.3-14.2). Median TD in Group C was 10.4 m. Maximum toxicity grade (≥3) and specific toxicities such as fatigue and hypertension were significantly reduced on schedule 2/1 in Group A compared with the initial schedule 4/2 (respectively, 8% vs 46% and 0% vs 10%, p < .001, and 2% vs 9%, p = .007). Conclusions: In our experience, sunitinib on a modified schedule 2/1 has an improved safety profile and increased efficacy compared with schedule 4/2. Prospective evaluation of this schedule is warranted.

Ma, Weijing, Christian Opp, and Dewei Yang. "Past, Present, and Future of Virtual Water and Water Footprint." Water 12, no. 11 (November 2, 2020): 3068. http://dx.doi.org/10.3390/w12113068.

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Virtual water and water footprint have received increasing attention. However, no published research has conducted a quantitative and objective review of this field from the perspective of bibliometrics. Therefore, based on the Web of Science Core Collection, this study employs CiteSpace to quantitatively analyze and visualize information about countries, institutions, and authors that have conducted virtual water and water footprint research over the past two decades. As of July 2020, there were 1592 publications on virtual water and water footprint, showing an increasing trend overall. The annual average number of publications was only 7.4 in 1998–2008, while it was 126.5 in 2009–2019. Among them, up to 618 publications in the field of environmental science, accounting for 46%. China was the most productive country with a total of 344 articles, but the Netherlands had the strongest influence with a betweenness centrality of 0.33, indicating its leading position. It is essential to strengthen cooperation between developed (water-rich) and developing (water-poor) countries and to incorporate virtual water into social water cycle research. This study is expected to provide a new perspective for investigating the research frontiers and hot spots of virtual water and water footprint research.

Victoir, K., J. C. Dujardin, S. De Doncker, D. C. Barker, J. Arevalo, R. Hamers, and D. Le Ray. "Plasticity of gp63 gene organization in Leishmania (Viannia) braziliensis and Leishmania (Viannia) peruviana." Parasitology 111, no. 3 (September 1995): 265–73. http://dx.doi.org/10.1017/s0031182000081828.

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SUMMARYThe genomic organization of gp63 genes in 4 and 7 isolates of Leishmania braziliensis and L. peruviana, respectively was studied by RFLP analysis with 3 restriction enzymes (Bgl I, Sal I and Apa I). Our results showed a marked polymorphism among isolates. Some characters were specific to L. braziliensis or to L. peruviana, and others specific to the respective biogeographical populations of L. peruviana. The average minimum copy number of gp63 genes was found to be higher in L. braziliensis (71) than in L. peruviana (46), suggesting that deletion of gp63 genes might be partially involved in the size decrease of the chromosome bearing gp63 genes, observed between those 2 species (from 700 to 610 kb). Our results may suggest the existence of at least 2 arrays of heterologous gp63 repeats, varying in relative copy number between L. braziliensis and L. peruviana, and among isolates of the latter species. Rearrangement of the gp63 genes was observed during long-term in vitro maintenance of a reference strain of L. braziliensis. These observations document the existence of a dynamic gp63 gene organization in Leishmania of the braziliensis complex.

Smith, Katie, L. Lanningham-Foster, Amy Welch, and Christina Campbell. "Web-Based Behavioral Intervention Increases Maternal Exercise but Does Not Prevent Excessive Gestational Weight Gain in Previously Sedentary Women." Journal of Physical Activity and Health 13, no. 6 (June 2016): 587–93. http://dx.doi.org/10.1123/jpah.2015-0219.

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Background:Innovative methods are warranted to optimize prenatal outcomes. This study’s objective was to determine if a web-based behavioral intervention (BI) can prevent excessive gestational weight gain (GWG) by increasing physical activity (PA).Methods:Participants were randomized to usual care (UC; n = 21) or BI (n = 24) between 10 to 14 weeks gestation. GWG, PA, and diet were assessed at baseline, mid-, and late pregnancy.Results:No differences in GWG or adherence to GWG recommendations presented between groups. Total UC MET-minutes significantly decreased from baseline to late-pregnancy (1,234 ± 372 MET-minutes, P = .013). Mid-pregnancy sustained PA was greater for BI than UC (20-minute PA bouts: 122 ± 106 vs. 46 ± 48 minutes/week, P = .005; 30-minute PA bouts: 74 ± 70 vs. 14 ± 24 minutes/week, P < .001), and greater for BI at mid-pregnancy compared with baseline (20-minute PA bouts: 61.3 ± 21.9; 30-minute PA bouts: 39.6 ± 14.8, both P < .05). BI energy intake at mid-pregnancy significantly increased from baseline (336 ± 127 kcals, P = .04) and was significantly greater than UC (2,503 ± 703 vs. 1,894 ± 594, P = .005).Conclusions:Sedentary pregnant women should increase PA but may need additional dietary counseling to prevent excessive GWG.

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Дисертації з теми "613.704 46":

Sadykowa, Elena. ""Kunst-Leben". Der Einfluss der russischen "religiösen Renaissance" auf die Ästhetik und Kunst des Spätsymbolismus zu Beginn des 20. Jahrhunderts in Russland." Doctoral thesis, 2005. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2005021010.

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Die vorliegende Arbeit befasst sich mit dem Phänomen der neuchristlichen Kunst in Russland nach der Oktober-Revolution 1917. Es gilt hier die philosophischen, geistesgeschichtlichen und kunsthistorischen Hintergründe zu erforschen, die zur Erscheinung der spätsymbolistischen Künstlervereinigung Kunst-Leben bzw. Makowez geführt haben. Dabei handelt es sich um eine scheinbar unzeitgemäße Vereinigung, deren Mitglieder sich den zeitgenössischen nihilistischen Tendenzen der russischen Kunst zum Trotz - den geistigen Traditionen der Weltkultur zuwandten. In ihren Kunstwerken thematisierten sie die Probleme der Religion, Mythologie, Spiritualität. In ihrem Manifest proklamierten sie die Entwicklung einer neuen, universellen Kunst, die als wahres Schöpfertum das Leben selbst erschaffen sollte. Das Anliegen der Verfasserin besteht darin, die Ursprünge dieses damals so untypischen Denkens in Russland zu nachvollziehen. Diese liegen in einem kulturhistorischen Phänomen der Jahrhundertwende vom 19. zum 20. Jahrhundert, das als russische religiöse Renaissance in die Kulturgeschichte Russlands eingegangen ist. Im ersten Kapitel werden die Voraussetzungen für die Entstehung dieses Phänomens aufgezeigt, welche die Verfasserin von der Ästhetik des deutschen Idealismus und von der Gesinnung der deutschen Romantik ableitet. Im zweiten Kapitel werden die genuin russischen symbolistisch-neuchristlichen ästhetischen Konzepte abgehandelt, die auf die ästhetischen Vorstellungen der russischen Künstler zu Beginn des 20. Jahrhunderts einen großen Einfluss ausübten. Dieser Einfluss ist das Thema des dritten Kapitels dieser Arbeit, in dem es um die theoretischen Auseinandersetzungen der russischen bildenden Künstler geht. Die vorliegende Dissertation trägt dazu bei, ein klareres Bild der damaligen Epoche der zwanziger Jahre in Russland zu gewinnen und ermöglicht ein tieferes Verständnis der Entstehung und Entwicklung der symbolistischen Weltanschauung in Russland.

Частини книг з теми "613.704 46":

Tosoni, Luca. "Article 93 Committee procedure." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0141.

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Article 28(7) (Standard contractual clauses); Article 40(9) (Codes of conduct); Article 43(9) (Certification mechanisms); Article 45(3) and (5) (Adequacy decisions); Article 46(2)(c)–(d) (Standard data protection clauses); Article 47(3) (Binding corporate rules); Article 61(9) (Format and procedures for mutual assistance); Article 67 (Exchange of information); Article 70(1) and (3) (Tasks of the Board); and Article 92 (Exercise of the delegation).

Leenes, Ronald. "Article 42 Certification." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0081.

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Article 5(2) (Principle of accountability); Article 24(3) (Responsibility of the controller); Article 25(3) (Data protection by design and by default); Article 28(5) (Responsibilities of the processor) (see too recital 81); Article 32(3) (Security of processing); Article 43 (Certification bodies); Article 46(2)(f) (Transfers subject to appropriate safeguards); Article 55 (Competence of the supervisory authorities); Article 56 (Tasks of the supervisory authorities); Articles 57(1)(n)–(q) (Tasks of the supervisory authorities) (see too recital 77); Article 58(h) (Powers of the supervisory authorities); Article 63 (Consistency mechanism); Article 64(1)(c) (Opinion of the Board); Article 70(1)(n)–(q) (Tasks of the Board); Article 93(4)(b) (General conditions for imposing administrative fines).

Hijmans, Hielke. "Article 57 Tasks." In The EU General Data Protection Regulation (GDPR). Oxford University Press, 2020. http://dx.doi.org/10.1093/oso/9780198826491.003.0099.

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Article 4(21) (Definition of a supervisory authority); Article 28(8) (Adoption of processors’ standard contractual clauses); Article 36(2) (Prior consultation) (see too recitals 84 and 94); Articles 40(1), (5) and 41(3) (Codes of conduct) (see too recital 98); Article 42(1), (5), (7) and 43(1) (Certification) (see too recital 100); Article 46(2)(d), (3) and (4) (Standard data protection clauses for data transfers) (see too recitals 108–109); Article 47 (Approval of binding corporate rules); Article 50 (International cooperation for the protection of personal data) (see too recitals 104 and 116); Article 58 (Powers) (see too recitals 129, 148 and 150); Article 59 (Activity reports); Article 60 (Cooperation between supervisory authorities); Article 61 (Mutual assistance between supervisory authorities); Article 62 (Joint operations of supervisory authorities); Article 70 (Tasks of the Board, including promotion of cooperation between supervisory authorities; contribution to activities of the Board); Article 77 (Complaint handling and investigations) (see too recital 141); Article 83 (Administrative fines) (see too recital 148).

Seco, Josi M., Emilio Quiqoa, and Ricardo Riguera. "The Theoretical Basis for Assignment by NMR." In The Assignment of the Absolute Configuration by NMR using Chiral Derivatizing Agents. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780199996803.003.0004.

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The nuclear magnetic resonance (NMR) spectra of two enantiomers are identical. Thus, the first step in using NMR to distinguish between two enantiomers should be to produce different spectra that eventually can be associated with their different stereochemistry (i.e., the assignment of their absolute configuration). Therefore, it is necessary to introduce a chiral reagent in the NMR media. There are two ways to address this problem. One is to use a chiral solvent, or a chiral agent, that combines with each enantiomer of the substrate to produce diastereomeric complexes/associations that lead to different spectra. This is the so-called chiral solvating agent (CSA) approach; it will not be further discussed here [33–34]. The second approach is to use a chiral auxiliary reagent [13–15] (i.e., a chiral derivatizing agent; CDA) that bonds to the substrate by a covalent linkage. Thus, in the most general method, the two enantiomers of the auxiliary CDA react separately with the substrate, giving two diastereomeric derivatives whose spectral differences carry information that can be associated with their stereochemistry. The CDA method that employs arylalcoxyacetic acids as auxiliaries is the most frequently used. It can be applied to a number of monofunctionals [14–15] (secondary alcohols [35–43], primary alcohols [44–46], aldehyde [47] and ketone cyanohydrins [48–49], thiols [50–51], primary amines [52–56], and carboxylic acids [57–58]), difunctional [13] (sec/sec-1,2-diols [59–61], sec/sec-1,2-amino alcohols [62], prim/sec-1,2-diols [63–65], prim/sec-1,2-aminoalcohols, and sec/prim-1,2-aminoalcohols [66–68]), and trifunctional (prim/sec/sec-1,2,3-triols [13, 69–70]) chiral compounds. Its scope and limitations are well established, and its theoretical foundations are well known, making it a reliable tool for configurational assignment. Figure 1.1 shows a summary of the steps to be followed for the assignment of absolute configuration of a chiral compound with just one asymmetric carbon and with substituents that, for simplicity, are assumed to resonate as singlets. Step 1 (Figure 1.1a): A substrate of unknown configuration (?) is separately derivatized with the two enantiomers of a chiral auxiliary reagent, (R)-Aux and (S)-Aux, producing two diastereomeric derivatives.

"are purified lipid contents and others are not, and the puri-(Paspalum scrobiculatum), and barnyard (Echinocloa fied lipid content depends on the purification method. colona). Sridhar and Lakshminarayana [32] also reported Starch lipids (SL) are those bound to starch, and they FL contents of 5.0, 5.6, and 2.2% for Proso, Foxtail, and are the most difficult to extract. Since true SL are present Finger millet, respectively. Taira [45] found slightly high-inside the starch granules, even a very polar solvent such er average FL (ether extraction) contents for glutinous as WSB cannot extract them at ambient temperature. Effi-foxtail millet (4.2-5.1%, average 4.7% of 21 samples) cient extraction of SL requires mixtures of hot aqueous al-than for nonglutinous foxtail millet (4.0-4.7%, average cohol in proportions optimized for controlled swelling of 4.4% of 31 samples). Among millet, pearl millet contains the starch granules and solubilization of the lipids [25]. the most FL. The best solvents are n-propanol or isopropanol with water Lipid contents of rice in Table 2 were cited by Morrison (3:1, by volume) used under nitrogen at 100°C. However, [3] using the data of Nechaev and Sandler [2]. Taira and some n-butanol—water and methanol-water mixtures also Chang [46] reported that the average nonglutinous brown are reasonably efficient extraction solvents at 100°C [25]. rice FL (ether extraction) contents of 20 varieties each of Recently, a third lipid category was introduced. Starch sur-Indica and Japonica types were 2.7% (2.38-2.91%) and face lipids (SSL) are portions of the nonstarch lipids 2.9% (2.54-3.58%), respectively. More recently, Taira et (NSL), which become firmly absorbed onto or into starch al. [47] reported the average FL contents of 15 nongluti-granules during the separation of pure starch [24]. nous varieties as 2.5% (2.24-2.97%) for Indica, 2.5% Lipids are minor components of the cereal grains shown (2.12-2.94%) for Japonica, 2.7% (2.35-3.03%) for Sinica, in Table 2. Data in this table, expressed on a dry basis, and 2.6% (2.11-2.99%) for Japonica types. were calculated from reported values [3,16,26-41]. Also, some BL or TL contents were calculated by subtracting FL from TL or by adding FL to BL, depending on the avail-B. Nonstarch Lipid Classes of Grains ability of data. The FL contents range from 1.5 to 2% of Lipids can be separated into three broad classes by open-the kernel weights of barley, rice, rye, triticale, and wheat column silicic acid chromatography. Nonpolar lipids (NL) grains. They range from 3 to 7% of the kernel weights of are first eluted by chloroform, glycolipids (GL) are eluted oats, millet, corn, and sorghum. However, BL contents in next by acetone, and phospholipids (PL) are eluted last grains are more uniform than FL contents. Therefore, the with methanol. Mixtures of GL and PL are polar lipids FL:BL ratio is substantially higher for corn, millet, oats, (PoL). After NL elution from a silicic acid column, PoL and sorghum than for rye, triticale, and wheat grains. The can be eluted with methanol without the GL elution step. FL:BL ratios for barley and rice are intermediate. Lipids can also be separated into various classes by thin-High oil-containing grains such as corn are continuous-layer chromatography (TLC) using different development ly bred for higher oil content with improved production solvent systems. Each individual lipid class migrates dif-yield. Application of wide-line NMR spectroscopy for ferently on the thin-layer plate, and the difference in mi-nondestructive analysis of the oil content in single corn gration rates makes it possible to separate complex lipids kernels made selection for higher oil content more efficient into classes. The NL consists of SE, TG, DG, MG, and [42]. Corn hybrids with 6-8.5% oil content and grain FFA (see Table 1). The total NL content is obtained by yields equal to those of good commercial hybrids were adding these NL class contents as measured by densitome-produced [43]. try. Thus, the NL content of samples may differ, to some Several kinds of millet exist, and the lipid data in the extent, depending on methodology used (column separa-literature are confusing. Rooney compared the FL (ether tion or TLC separation). extraction) contents of several types of millet in a review The data [1,13,27,29,32,36-38,40,48-58] shown in paper [16]. The average FL contents of pearl millet (Pen-Table 3 may be used for only approximate comparison of nisetum typhoids) were 5.1% (4.1-5.6%, 14 samples), the NL content from different grains because some were 5.4% (2.8-8.0%, 167 samples, [44]), 5.6% (4.3-7.1%, 40 obtained by column chromatography and some by TLC. samples), and 6.2% (4.2-7.4%, 35 samples) [16]. Other All cereal grain lipids are richer in NL than in other class-reported average FL contents were 4.8% (4.6-5.0%, 6 es: 60-70% of the TL are NL in wheat (hexaploid), triti-samples) for foxtail millet (Setaria Italica), 5.8% cale, and rye; 65-80% for barley and oat groats; 77-87% (5.5-6.3%, 6 samples) for Japanese millet (Echinochloa for sorghum and rice; and 75-96% for corn and millet crusgalli), and 4.2% (3.8-4.9%, 20 samples) for proso (Pennisetum americanum). Sridhar and Lakshminarayana millet (Panicum miliaceum) [16]. Sridhar and Lakshmi-[32] reported 82, 80, and 79% of NL for Foxtail, Proso, narayana [30] reported a FL content range of 3.4-5.7% for and Finger millet, respectively. There are significant vari-small millet, including little (Panicum sumatrense), kodo etal effects on the NL/PoL ratio for corn and millet (P." In Handbook of Cereal Science and Technology, Revised and Expanded, 434. CRC Press, 2000. http://dx.doi.org/10.1201/9781420027228-43.

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Тези доповідей конференцій з теми "613.704 46":

Scher, Luísa Gehrke, Simone Stefanelo, and Denize Da Rosa Fraga. "MONITORAMENTO DE VACAS LEITEIRAS NO PERÍODO DE TRANSIÇÃO." In I Congresso Brasileiro Online de Práticas Veterinárias: Uma abordagem para animais de grande porte e produção Animal. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/granvet-46.

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Introdução: Dentro da bovinocultura de leite problemas metabólicos ocorrem com maior frequência no período de transição, sendo este considerado o período mais crítico que pode comprometer toda a expectativa de produção da lactação. Alguns métodos de manejo nutricional, como o balanço cátion-aniônico da dieta (BCAD) com o uso de sais aniônicos no período pré-parto (21 dias antes do parto) vem sendo uma estratégia utilizada, de forma a promover acidificação do pH sanguíneo e consequentemente o pH urinário e prevenir casos de hipocalcemia, que é uma das enfermidades mais prevalentes deste período. Objetivos: Relacionar dados de mensuração de pH urinário no pré-parto de vacas leiteiras recebendo dieta aniônica com a incidência de patologias no pós-parto (hipocalcemia, retenção de placenta e metrite). Material e métodos: Acompanhamento do período de transição de seis vacas da raça holandesa, em sistema semi-confinado. Durante o período pré-parto, amostras de urina das vacas foram coletadas, através de micção espontânea dos animais. Logo após feita a mensuração do pH urinário, por meio de medidor de pH digital (ATC®). Após o parto, os animais foram acompanhados buscando verificar a ocorrência de patologias e novamente feita a coleta de urina e mensuração de pH urinário. Resultados: Verificou-se nos animais objeto de estudo um pH urinário médio no pré-parto e pós-parto respectivamente de: vaca A 6 e 8.7, vaca B 6.6 e 7.4, vaca C 5.8 e 7.1, vaca D 5.7 e 7.2, vaca E 6.3 e 7.6, vaca F 6.1 e 8.6, tendo como uma média no pré-parto de 6.3, valor dentro dos padrões esperados. E o pH urinário pós-parto médio foi de 7.8, também dentro do esperado. Ao avaliar a ocorrência de doenças no pós-parto constatou-se que não houve nenhum caso de hipocalcemia clínica, não sendo realizado nenhum tratamento com suplementação de cálcio. Conclusão: A utilização de dieta aniônica pré-parto, foi eficiente para promover acidificação do pH urinário das vacas. Constatando-se que não ocorreu nenhum caso de hipocalcemia, principal objetivo da dieta, conclui-se que a verificação do pH urinário é um método simples e eficiente para orientação de veterinários e produtores.

Rivza, Baiba, and Uldis Plumite. "LATVIAN THEME PARK DEVELOPMENT IN KURZEME AND VIDZEME." In GEOLINKS Conference Proceedings. Saima Consult Ltd, 2021. http://dx.doi.org/10.32008/geolinks2021/b2/v3/36.

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The economy of Latvia is experiencing rapid development in the European Union and is an active participant of the United Nations and North Atlantic Treaty Organization. In recent years there have been several changes in both sectors and national economic policy. The total population in Latvia was estimated at 1.9 million inhabitants in 2019 and a total GDP per capita was 63% of the EU average, the lowest GDP per capita in purchasing power parity was recorded in Bulgaria - 46% of the EU average, Romania - 60% and Croatia - 62%. Lithuanian and Estonian GDP per capita in 2019 was accounted for 74% of the EU average. Latvia has more than 12 theme parks, but the amusement offer is small. Most of the theme parks are mostly located in Kurzeme and Vidzeme. Attraction Parks historically evolved near the big cities, where the infrastructure is highly developed. The aim is to increase the influx of tourists in regions where tourism products are amusement parks, thus developing more local businesses and the city's environment, increasing the demand for an active economic environment, but regional laws often hinder this development.

Mansani, Fabio Postiglione, Márcia Magalhães Fernandes, and Ruffo de Freitas-Junior. "IMPACT OF THE MAMMAPRINT GENETIC SIGNATURE ON THE DECALONATION OF THE CHEMOTHERAPY TREATMENT IN A MEDIUM INCOME COUNTRY – STUDY OF REAL LIFE." In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2023.

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Introduction: Genetic signatures have been used in the attempt of de-escalate the treatment of breast carcinoma, reducing the indication for adjuvant chemotherapy (CTAd) in patients with luminal tumors with high clinical risk. The MINDACT trial, using the 70 gene platform MammaPrintTM, analyzing a cohort of European patients, showed that it was possible to save 46% of the use of CTAd in this population. However, there is a lack of information regarding the impact of this platform in the low- and medium-income countries (LMIC). Objective: The objective of this study was to analyze the Brazilian population with luminal breast cancer with high clinical risk, subjected to genomic analysis by the MammaPrintTM signature, the percentage of de-escalation of the systemic treatment, saving patients with low genomic risk from chemotherapy, using the MINDACT trial criteria. Methodology: Data were collected from 815 patients who underwent the MammaPrintTM genetic platform, provided by the GenCell Pharma database, from several Brazilian states, with luminal profile, by immunohistochemistry (IHC), breast carcinoma, and high clinical risk by the criteria of the MINDACT trial. The percentage of these patients who had a low genomic risk was calculated using MammaPrintTM. Patients were categorized by age group and menopausal status. The correlation of low and high clinical and genomic risks was also analyzed according to the Brazilian macro-regions, considering the municipal human development index (MHDI). MammaPrintTM values ³0.355 were considered to be genomic ultra-low risk. Results: The age of the patients ranged between 29 and 97 years. Of the 815 patients, 14 (1.71%) had a non-luminal profile to BluePrintTM and were excluded, although demonstrating that there was a strong statistical significance between IHC and BluePrintTM. Out of 801 luminal profile patients of high clinical risk to MammaPrintTM, 477 had low genomic risk, representing a percentage of 59.5%. Of the patients with low genomic risk 124 (15.48%) were ultra-low risk, considering the cutoff of 0.355. When assessing the age group, low genomic risk represents 46% of patients aged below 35 years, 51% of those aged between 35 and 49 years old, 61% aged between 50 and 70 years, and 64% of patients aged above 70 years old. Taking into consideration the menopausal status, 51% of low genomic risk were premenopause and 62% were postmenopause women. The correlation between the MHDI of the Brazilian macro regions and the presence of breast cancer of high genomic risk was not statistically significant. Conclusions: The use of the MammaPrintTM genetic signature in a Brazilian cohort, with high clinical risk, demonstrated that 59.5% of the patients could be spared from CTAd, more markedly in the postmenopause women, which represents 62% of the sample. This real-life study showed that for LMICs, MammaPrintTM can generate an even more significant CTAd de-escalation than that observed in the European cohort by the MINDACT study. A broader assessment with analysis of the clinical outcome is needed to confirm these results.

Amaral Neto, Antonio Serpa do, Eduarda Jaskulski, Eduardo Martins Leal, Matheus Marquardt, Gabriel de Deus Vieira, and Joana Capano Hawerroth. "Neurotuberculosis with intracerebral tuberculoma and PCR for detectable Mycobacterium in CSF." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.710.

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Introduction: Neurotuberculosis is the most serious form of extrapulmonary tuberculosis. The main clinical presentation is meningoencephalitis, which may be associated with tuberculomas. The detection of Mycobacterium tuberculosis by CSF in CSF is still a diagnostic challenge. Objectives: To report a clinical case of neurotuberculosis associated with intracranial tuberculoma with detection of Mycobacterium tuberculosis by CSF in CSF. Methods: Neurotuberculosis is the most serious form of extrapulmonary tuberculosis. The main clinical presentation is meningoencephalitis, which may be associated with tuberculomas. The detection of Mycobacterium tuberculosis by CSF in CSF is still a diagnostic challenge. Results: C. A. G., 45 years old, female, admitted to the hospital in January 2020, presenting holocranial, pulsatile headache, which had worsened for 5 days, with little response to analgesics, associated with an episode of tonic-clonic seizure crisis, without other clinical signs. Previous diagnosis of asthma, using continuously salbutamol and beclomethasone. Examinations were requested - BAAR search for positive sputum, rapid molecular sputum test revealing Mycobacterium tuberculosis, clear-looking CSF, detectable CRP for Mycobacterium tuberculosis, glucose 63, protein 56.3, total cytology 74 (35% neutrophils, 19% lymphocytes , 46% macrophages). The cranial tomography showed a nodular lesion in the corticosubcortical region of the left frontal lobe, with annular enhancement by means of contrast, measuring 3.9 x 3.9 cm, in addition to accentuated meningeal enhancement. Chest tomography showed hollowed-out lesions with thickened walls, with the appearance of a sprouting tree, predominating in the lower lobe of the right lung. The diagnoses of neurotuberculosis (cerebral tuberculoma and meningitis) and pulmonary tuberculosis were then established. Referred to the infectious disease referral hospital using RHZE associated with dexamethasone and phenytoin. After 48 hours of hospitalization, the patient evolved with confusion and mental disorientation, suspecting complex subentrant partial seizures with a confused post-ictal state. A new skull tomography was requested, which showed an expansive lesion with an ovoid aspect 4.5 x 3.3 cm with liquefied content and ring impregnation by means of contrast in the upper left frontal region with mass effect and significant perilesional edema. Electroencephalogram showed disorganized base activity, periodically, sometimes with three-phase morphology, sometimes acute, in both hemispheres, with greater projection to the left and epileptiform activity also in the frontal- temporal region, bilaterally and independently. After therapeutic adjustment, the patient remained clinically stable and was discharged from the hospital with outpatient followup due to infectious diseases and neurology. Conclusion: The case addressed draws attention to the different neurological manifestations observed in neurotuberculosis, such as headache, seizures, confusion and disorientation. Early diagnosis and treatment is important to achieve a favorable outcome.