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Статті в журналах з теми "621.396 (043.3)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Armstrong, April W., Mark Lebwohl, Richard B. Warren, et al. "Deucravacitinib in Plaque Psoriasis: 3-year Safety and Efficacy Results from the Phase 3 POETYK PSO-1 and PSO-2 Trials." SKIN The Journal of Cutaneous Medicine 8, no. 2 (2024): s366. http://dx.doi.org/10.25251/skin.8.supp.366.

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Introduction: Deucravacitinib, an oral, selective, allosteric TYK2 inhibitor, is approved in the US, EU, and other countries for treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. Deucravacitinib was superior to placebo and apremilast in the POETYK PSO-1 (NCT03624127) and PSO-2 (NCT03611751) parent trials in moderate to severe plaque psoriasis. The POETYK long-term extension (LTE; NCT04036435) trial enrolled patients completing PSO-1/PSO-2. We report deucravacitinib safety and efficacy for up to 3 years (Week 148; through cutoff 6/15/2022).&#x

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2

VASUDEVA, A. ADHIKARI, and V. BADIGER VIRUPAX. "Synthesis and Antimicrobial Activities of some lsoxazolo-[5',4' : 4,5]pyrimido[6,1-c]1,2,4-triazine Derivatives." Journal of Indian Chemical Society Vol. 65, Jul 1988 (1988): 500–503. https://doi.org/10.5281/zenodo.6296393.

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Department of Chemistry, Karnatak University, Dharwad-580 003 <em>Manuscript received 25 November 1987, revised 23 March 1988, accepted 6 April 1988</em> 4-Hydrazino-3,6-disubstituted isoxazolo[5,4-<em>d</em>]pyrimidines (3a- i), when treated with 1-chloro-2-propanone yielded (3,6-disubstituted-isoxazolo[5,4-<em>d</em>]pyrimidine-4-yl)hydrazones of 1-chloro-2-propanone ( 4a- i), which on cyclisation produced the title compounds, viz 6,10-disubstituted-3-methyl-4<em>H</em>-isoxazolo[5',4': 4, 5]pyrimido[6,1-c) 1,2,4-triazines (5a- i). Structures of new compounds have been established by

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3

Beer, Tomasz M., Christopher Logothetis, Winald R. Gerritsen, et al. "Characterization of immune-related adverse events (irAEs) in a phase 3 trial of ipilimumab (Ipi) versus placebo (Pbo) in post-docetaxel mCRPC." Journal of Clinical Oncology 32, no. 4_suppl (2014): 52. http://dx.doi.org/10.1200/jco.2014.32.4_suppl.52.

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52 Background: Ipi enhances antitumor immunity by blocking cytotoxic T-lymphocyte antigen-4. We recently reported the results of CA184-043, a phase 3 study of post-docetaxel mCRPC with Ipi vs Pbo, following single-dose radiotherapy (RT). While the study did not meet the primary endpoint of improving overall survival (HR=0.85, p=0.053), Ipi demonstrated antitumor activity in other efficacy endpoints, including progression-free survival. The present analyses further characterize the safety profile of Ipi in this study. Methods: Safety was evaluated for all treated patients (pts; N=393 for Ipi 10

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4

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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5

Bardak, Handan, Yavuz Bardak, Yeşim Erçalık, Burak Erdem, Gökhan Arslan, and Semrin Timlioglu. "Sequential tissue plasminogen activator, pneumatic displacement, and anti-VEGF treatment for submacular hemorrhage." European Journal of Ophthalmology 28, no. 3 (2018): 306–10. http://dx.doi.org/10.5301/ejo.5001074.

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Purpose: To report the results of our sequential intravitreal (IV) tissue plasminogen activator (tPA), pneumatic displacement (PD), and IV anti-vascular endothelial growth factor (VEGF) treatment in patients with neovascular age-related macular degeneration (nAMD)-related submacular hemorrhage (SMH). Methods: A total of 16 eyes of 16 patients with SMH of less than 15 days duration were included in this retrospective pilot study. The tPA was applied on the day of diagnosis, and PD was performed the following day. Patients received 3 consecutive monthly IV injections of ranibizumab starting from

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6

Paal, Jaanus, Eli Fremstad, and Tõnu Möls. "Responses of the Norwegian alpine Betula nana community to nitrogen fertilization." Canadian Journal of Botany 75, no. 1 (1997): 108–20. http://dx.doi.org/10.1139/b97-013.

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The effect of nitrogen fertilization on species cover, increment of shrubs, tissue nitrogen, and soil parameters was tested during a 3-year experiment in a low alpine plant community dominated by Betula nana in the Dovre mountains, south-central Norway. The doses used were 1.2 and 6.1 g N/m2, corresponding to 0.72 and 3.6 times, respectively, the annual deposition of nitrogen in southwest Norway. Statistical analysis using SAS ANOVA and GLM procedures were applied to different types of models. The cover of species and growth forms showed no significant response to additional nitrogen supply. T

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7

Lee, Si Xian Jasmine, Tracy Burrows, Serene Yoong, and Rebecca Wyse. "Association of parental investment of time and cost in food provisioning with adherence to dietary guidelines for the consumption of fruits, vegetables and non-core foods in pre-schoolers." Public Health Nutrition 21, no. 13 (2018): 2434–42. http://dx.doi.org/10.1017/s1368980018001465.

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AbstractObjectiveTo assess whether parent-reported time and cost for provision of food is associated with consumption of fruits, vegetables and non-core foods in pre-schoolers.DesignCross-sectional analysis of baseline data from the Healthy Habits randomised controlled trial. Two subscales of the Children’s Dietary Questionnaire (CDQ) were used to assess fruit and vegetable, and non-core food consumption.SettingThirty pre-schools in the Hunter Region of New South Wales, Australia.SubjectsParents (n 396) with a child aged 3–5 years attending a participating pre-school were recruited. Parents ne

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8

Smolen, J. S., T. Korotaeva, M. Nurmohamed, et al. "AB0530 EFFECT OF SKIN SYMPTOMS ON DISEASE IMPACT IN PATIENTS WITH PSORIATIC ARTHRITIS RECEIVING THE IL-12/23 INHIBITOR USTEKINUMAB OR TNF INHIBITORS IN THE REAL-WORLD PSABIO STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1295–96. http://dx.doi.org/10.1136/annrheumdis-2021-eular.767.

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Background:Psoriatic arthritis (PsA) is characterised by musculoskeletal symptoms, and patients (pts) with PsA usually experience psoriasis concurrently. Real-world data reflecting impact of skin symptoms on PsA disease burden are limited.Objectives:Analyse effectiveness of ustekinumab (UST) and tumour necrosis factor inhibitor (TNFi) therapy on extent of skin involvement, and the impact this has on PsA disease burden and drug persistence.Methods:PsABio (NCT02627768) is a prospective, observational study of 1st/2nd/3rd-line UST or TNFi treatment in PsA in 8 European countries. Extent of skin i

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9

Kojima, Takashi, Takashi Ogata, Ryu Ishihara, et al. "First-line (1L) tislelizumab (TIS) plus chemotherapy (CT) vs placebo (PBO) plus CT in advanced/metastatic esophageal squamous cell carcinoma (ESCC): RATIONALE-306 Japanese subgroup analysis with longer follow-up." Journal of Clinical Oncology 43, no. 4_suppl (2025): 420. https://doi.org/10.1200/jco.2025.43.4_suppl.420.

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420 Background: In the global phase 3 RATIONALE-306 study (NCT03783442), TIS + CT showed a significant overall survival (OS) benefit vs PBO + CT as 1L therapy for advanced/metastatic ESCC. After a minimum 3-year follow-up, the hazard ratio (HR) for OS was 0.70 for all randomized patients (pts) and for pts with programmed death-ligand 1 (PD-L1) Tumor Area Positivity (TAP) score ≥10%.We report results for the Japanese subgroup. Methods: Eligible pts enrolled in Japan were randomized (1:1) to receive intravenous TIS 200 mg or PBO every 3 weeks + investigator-chosen CT (platinum + fluoropyrimidine

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10

Bossu, Carla Maíra, Vivian Montes de Oca Carioni, Juliana Naozuka, Pedro Vitoriano de Oliveira, and Cassiana Seimi Nomura. "Direct determination of arsenobetaine and total As in robalo fish liver and tuna fish candidate reference material by slurry sampling graphite furnace atomic absorption spectrometry (SLS-GF AAS)." Eclética Química Journal 44, no. 2 (2019): 37. http://dx.doi.org/10.26850/1678-4618eqj.v44.2.2019.p37-44.

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This work describes a simple and rapid screening method for direct speciation of arsenobetaine (AsB) in tuna fish tissue and total As in tuna fish tissue and robalo liver using SLS-GF AAS. All procedures were proposed after careful optimization of pyrolysis and evaluation of chemical modifiers. Best results for total As were acquired using 25 µg Pd + 15 µg Mg + 0.1% w/v Triton X-100 in tuna fish (4.4 ± 0.3 mg kg-1) and 100 µg Pd + 0.1 % w/v Triton X-100 solution in robalo liver (10.3 ± 0.6 mg kg-1) as chemical modifiers. The direct speciation of AsB (3.6 ± 0.4 mg kg-1) in tuna fish was achieve

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Okpala, Iheanyi, Hongmei Ren, Kebreab Ghebremeskel, Cynthia Ugochukwu, Obike Ibegbulam, and Michael Crawford. "Blood Mononuclear Cells and Platelets Have Abnormal Fatty Acid Composition in Homozygous Sickle Cell Disease." Blood 104, no. 11 (2004): 3727. http://dx.doi.org/10.1182/blood.v104.11.3727.3727.

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Abstract Leukocyte adhesion to vascular endothelium contributes to vaso-occlusion and widespread organ damage in sickle cell disease (SCD). Previously, we found high expression of the adhesion molecules αMβ2 integrin and L-selectin in HbSS individuals with severe disease. The n-6 and n-3 polyunsaturated fatty acids (FA) are vital structural and functional components of cell and sub-cellular membranes. They modulate cell adhesion, inflammation, aggregation and vascular tone. We investigated the FA composition of mononuclear cells (MNC) and platelets of HbSS patients in steady-state (n = 28); an

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12

Nabi, Zaheer, Mohan Ramchandani, Radhika Chavan, et al. "Per-oral endoscopic myotomy for achalasia cardia: outcomes in over 400 consecutive patients." Endoscopy International Open 05, no. 05 (2017): E331—E339. http://dx.doi.org/10.1055/s-0043-105517.

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Abstract Background and study aims Per-oral endoscopic myotomy (POEM) has emerged as an efficacious treatment modality for the management of achalasia cardia (AC) and non-achalasia spastic esophageal motility disorders. Initial results are encouraging. We analyzed the safety and efficacy of POEM in a large cohort of patients with AC. Patients and methods The data from patients who underwent POEM (from January 2013 to June 2016) was prospectively collected and analyzed. Clinical success was defined as Eckardt score ≤ 3 after POEM procedure. Objective parameters including high-resolution manomet

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13

Moral, K., E. Bilgin, O. Karadag та ін. "AB0943 EVALUATION OF THE EFFECT OF TUMOR NECROSIS FACTOR - Α THERAPY ON 24-HOUR AMBULATORY BLOOD PRESSURE MEASUREMENT AND SLEEP QUALITY IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS". Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1689. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6219.

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BackgroundIncreased cardiovascular mortality has been reported in AS patients. There are studies showing the positive effects of anti-TNF-α therapy on both cardiovascular mortality and sleep quality. (1,2)ObjectivesTo determine the changes in sleep quality and 24-hour blood pressure readings in patients with axial spondiloarthritis (axSpA) after treatment with anti- tumor necrosis factor TNF-α therapy.MethodsPatients with axSpA who were admitted to Hacettepe University Hospital Rheumatology outpatient clinic between 01.03.2021 and 01.12.2021, anti-TNF-naive and without a history of cardiovascu

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14

De, Kishalay, Deepto Chakrabarty, Roberto Soria, et al. "A Massive AGB Donor in Scutum X-1: Identification of the First Mira Variable in an X-Ray Binary." Astrophysical Journal Letters 928, no. 1 (2022): L8. http://dx.doi.org/10.3847/2041-8213/ac5b11.

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Abstract The symbiotic X-ray binary Sct X-1 was suggested to be the first known neutron star accreting from a red supergiant companion. Although known for nearly 50 yr, detailed characterization of the donor remains lacking, particularly due to the extremely high reddening toward the source (A V ≳ 25 mag). Here, we present (i) improved localization of the counterpart using Gaia and Chandra observations, (ii) the first broadband infrared spectrum (≈1–5 μm; R ≈ 2000) obtained with SpeX on the NASA Infrared Telescope Facility, and (iii) the J-band light curve from the Palomar Gattini-IR survey. T

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15

Bialik, E. I., M. A. Makarov, V. A. Nesterenko, et al. "Evaluation of the efficacy of high molecular weight hyaluronic acid with chondroitin sulfate in post-traumatic knee osteoarthritis." Modern Rheumatology Journal 18, no. 4 (2024): 59–65. http://dx.doi.org/10.14412/1996-7012-2024-4-59-65.

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Objective: to evaluate the efficacy of a single or double administration of a preparation of high molecular weight hyaluronic acid (HLA) with chondroitin sulfate (CS) in post-traumatic knee osteoarthritis (OA). Material and methods. The study included 91 patients with stage III post-traumatic knee OA. All patients received intra-articular (i/a) injection of high molecular weight HLA with CS; 36 patients received the drug once (group 1) and 55 twice (group 2) with an average interval of 7±2 days. Before the start of treatment and 2 weeks, 1, 3, 6 and 12 months after i/a injection of HLA, pain i

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16

Zhong, Runbo, Min Yan, Qiming Wang, et al. "Phase 1 trial of SHR-A2102, a nectin-4–directed antibody drug conjugate (ADC), in advanced solid tumors." Journal of Clinical Oncology 43, no. 16_suppl (2025): 107. https://doi.org/10.1200/jco.2025.43.16_suppl.107.

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107 Background: Nectin-4 is a cell adhesion molecule that is highly expressed in a wide variety of cancers and is associated with poor prognosis. SHR-A2102 is a novel ADC consisting of a fully humanized Nectin-4–directed monoclonal antibody, bound to topoisomerase I inhibitor payload via a cleavable linker. We conducted a multi-center, phase 1 trial to evaluate SHR-A2102 in advanced solid tumors. Methods: Patients (pts) with Nectin-4 positive, locally advanced unresectable or metastatic solid tumors were enrolled. The study included dose-escalation (D-ESC), dose-expansion (D-EXP) and efficacy-

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Raila, Gediminas, Greta Gedvilienė, Aušrinė Kontrimienė, et al. "Pirminėje sveikatos priežiūroje dirbančių specialistų požiūris į komandinį darbą." Lithuanian General Practitioner 24, no. 10 (2020): 693–700. http://dx.doi.org/10.37499/lbpg.601.

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Tyrimo tikslas. Pastaraisiais dešimtmečiais sveikatos priežiūros įstaigos vis dažniau susiduria su situacijomis, kai, norint teikti efektyvias ir kokybiškas paslaugas reikalingas komandinis darbas. Sveikatos priežiūros specialistų negebėjimas dirbti kartu komandoje yra viena iš sistemos nesėkmių, dėl kurių gali nukentėti pacientų saugumas. Todėl mūsų tyrimo tikslas buvo ištirti pirminės sveikatos priežiūros (PSP) specialistų požiūrį į komandinį darbą ir rasti sąsajas tarp požiūrio į komandinį darbą bei sociodemografinių rodiklių. Tiriamųjų kontingentas ir tyrimo metodai. Tyrimo dalyviai buvo 9

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18

Joseph, Nisha S., Shruti Gupta, Jonathan L. Kaufman, et al. "Impact of Self-Identified Race on Outcomes in Newly Diagnosed Multiple Myeloma (NDMM) Patients Receiving Induction Therapy with Daratumumab, Lenalidomide, Bortezomib and Dexamethasone (D-RVd)." Blood 144, Supplement 1 (2024): 7870. https://doi.org/10.1182/blood-2024-211988.

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Introduction: Following the results of the phase 3 PERSEUS trial, the addition of daratumumab to RVD (D-RVd) has become standard of care with improved depth of response and PFS benefit. We have previously presented data from our institutional database of 326 patients induced with D-RVd consistent with the clinical trial findings of improved efficacy over RVd alone. Here, we present subgroup analysis on outcomes of white and black newly diagnosed myeloma (NDMM) patients induced with D-RVd. Methods: 326 NDMM patients treated with D-RVd induction therapy from April 2018 - August 2022 were include

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Saddawi-Konefka, Robert, Aoife O’Farrell, Farhoud Faraji, et al. "601 Sequencing immunotherapy before lymphatic ablation unleashes cDC1-dependent antitumor immunity in HNSCC." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A631. http://dx.doi.org/10.1136/jitc-2021-sitc2021.601.

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BackgroundDespite the proven efficacy of immune checkpoint inhibitor (ICI) therapy in the recurrent/metastatic setting for head and neck squamous cell carcinoma (HNSCC), clinical trials of ICI combined with curative-intent therapies have yielded equivocal results [1–4]. Collectively, this highlights gaps in our understanding of rational immune oncology (IO) treatment sequencing and suggests that the efficacy ICI may be disrupted by standard therapies, which necessarily compromise regional lymphatics.MethodsWe employ a preclinical model of tobacco-signature HNSCC to identify sequences of therap

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Bartlett, S. J., C. Bingham, O. Schieir, et al. "POS1459-HPR IDENTIFYING MEANINGFUL CHANGE IN THE RA FLARE QUESTIONNAIRE SCORES IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1014–15. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1663.

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Background:The RA-FQ is a patient-reported measure of current disease activity in RA that can be used to identify disease flares. The RA-FQ queries pain, physical function, fatigue, stiffness, and participation and yields a score from 0-50. We previously reported on reliability, validity, and responsiveness.Objectives:To identify changes in RA-FQ that represent minimal and meaningful improvement or worsening from the perspective of people with RA, treating rheumatologists, and in relation to disease activity indices. We hypothesized thatMethods:Data were from adults with early RA (sx <1 yea

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21

Xu, Rongbin, Tingting Ye, Xu Yue, et al. "Global population exposure to landscape fire air pollution from 2000 to 2019." Nature 621, no. 7979 (2023): 521–29. http://dx.doi.org/10.1038/s41586-023-06398-6.

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AbstractWildfires are thought to be increasing in severity and frequency as a result of climate change1–5. Air pollution from landscape fires can negatively affect human health4–6, but human exposure to landscape fire-sourced (LFS) air pollution has not been well characterized at the global scale7–23. Here, we estimate global daily LFS outdoor fine particulate matter (PM2.5) and surface ozone concentrations at 0.25° × 0.25° resolution during the period 2000–2019 with the help of machine learning and chemical transport models. We found that overall population-weighted average LFS PM2.5 and ozon

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Peterson, B. T., J. A. Brooks, and R. W. Hyde. "Lung fluid balance during acute renal failure in sheep." Journal of Applied Physiology 60, no. 4 (1986): 1333–40. http://dx.doi.org/10.1152/jappl.1986.60.4.1333.

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To determine whether uremia changes lung vascular permeability, we measured the flow of lymph and proteins from the lungs of acutely uremic sheep. Acute renal failure was induced by either bilateral nephrectomy or by reinfusing urine. Both models of renal failure increased the plasma creatinine from 0.8 +/- 0.3 to 11 +/- 1 mg/dl in 3 days but caused no significant change in the flow of lymph from the lungs. To determine whether uremia increased the protein clearance response to elevated pulmonary microvascular pressures, we inflated a balloon in the left atrium for 2 h before and 3 days after

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Park, Chang-Hwan, Woo Paik, Eun Park, et al. "Aggressive intravenous hydration with lactated Ringer’s solution for prevention of post-ERCP pancreatitis: a prospective randomized multicenter clinical trial." Endoscopy 50, no. 04 (2017): 378–85. http://dx.doi.org/10.1055/s-0043-122386.

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Abstract Background and study aims The present study aimed to determine the type of intravenous hydration that is best suited to reducing the incidence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Patients and methods In a prospective randomized multicenter trial, average-to-high risk patients who underwent first-time ERCP were randomly assigned to three groups (1:1:1) who received: aggressive intravenous hydration (3 mL/kg/h during ERCP, a 20-mL/kg bolus and 3 mL/kg/h for 8 hours after ERCP) with either lactated Ringer’s solution (LRS) or normal saline solution

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Hankins, David A., Ian E. Fletcher, Fermin Prieto, et al. "Critical Evaluation of the Methodologic Quality of the Top 50 Cited Articles Relating to Knee Dislocation and Multiligamentous Knee Injury." Orthopaedic Journal of Sports Medicine 7, no. 11 (2019): 232596711988050. http://dx.doi.org/10.1177/2325967119880505.

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Background: Many studies have evaluated the management of knee dislocations (KDs) and multiligamentous knee injuries (MLKIs). However, no study to date has analyzed the quality of the most cited articles in this literature. Hypothesis: There is a positive correlation between the number of article citations in the KD and MLKI literature and their methodologic quality. Study Design: Systematic review. Methods: The Web of Science online database was searched to identify the top 50 cited articles in KD and MLKI care. Demographic data were recorded for each study. The Modified Coleman Methodology S

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Li, Tianhong, Mei Tang, Karen Kelly, et al. "949 First-in-human study of the first acid pH-sensitive and recycling CTLA-4 antibody that preserves the immune tolerance checkpoint to avoid immunotherapy-related adverse events in cancer patients." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A998. http://dx.doi.org/10.1136/jitc-2021-sitc2021.949.

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BackgroundCTLA-4 is the first immune checkpoint target for cancer immunotherapy. However, the clinical benefit of targeting CTLA-4 has been limited by suboptimal doses and early discontinuation due to immunotherapy-related adverse events (irAE). Our preclinical studies suggest that acid pH-sensitive anti-CTLA-4 antibodies that preserve CTLA-4 recycling and avoid lysosomal degradation are more effective for immunotherapy but largely devoid of immunotherapy-related adverse events (irAE) [1-6]. To test this new hypothesis in human, we initiated first-in-human study evaluating the safety and toler

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Bangsbo, Jens, Peter Krustrup, José González-Alonso, and Bengt Saltin. "ATP production and efficiency of human skeletal muscle during intense exercise: effect of previous exercise." American Journal of Physiology-Endocrinology and Metabolism 280, no. 6 (2001): E956—E964. http://dx.doi.org/10.1152/ajpendo.2001.280.6.e956.

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The aim of the present study was to examine whether ATP production increases and mechanical efficiency decreases during intense exercise and to evaluate how previous exercise affects ATP turnover during intense exercise. Six subjects performed two (EX1 and EX2) 3-min one-legged knee-extensor exercise bouts [66.2 ± 3.9 and 66.1 ± 3.9 (±SE) W] separated by a 6-min rest period. Anaerobic ATP production, estimated from net changes in and release of metabolites from the active muscle, was 3.5 ± 1.2, 2.4 ± 0.6, and 1.4 ± 0.2 mmol ATP · kg dry wt−1· s−1during the first 5, next 10, and remaining 165 s

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Friel, James K., Jamie C. Bessie, Suresh L. Belkhode, et al. "Thiamine, Riboflavin, Pyridoxine, and Vitamin C Status in Premature Infants Receiving Parenteral and Enteral Nutrition." Journal of Pediatric Gastroenterology and Nutrition 33, no. 1 (2001): 64–69. http://dx.doi.org/10.1002/j.1536-4801.2001.tb07403.x.

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ABSTRACTBackgroundThere is a paucity of data about water soluble vitamin status in low birthweight infants. Therefore, the authors' objective was to assess current feeding protocols.MethodsThe authors measured serum concentrations for riboflavin, pyridoxine, and vitamin C and functional assays for thiamine and riboflavin longitudinally in 16 premature infants (birthweight, 1,336 ± 351 g; gestational age, 30 ± 2.5 weeks) before receiving nutrition (time 1, 2 ± 1 days), during supplemental or parenteral nutrition (time 2, 16 ± 10 days) and while receiving full oral feedings (time 3, 32 ± 15 days

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Wang, Siqiao, Shun Chen, Meiyi Chen, et al. "Global, regional and national burden of infections among pregnant women, 1990–2021: a prospective cohort study." BMJ Open 15, no. 6 (2025): e096746. https://doi.org/10.1136/bmjopen-2024-096746.

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ObjectivesWe aimed to analyse the trends, age distribution and disease burden of maternal sepsis and other maternal infections (MSMI) to improve management strategies.DesignWe extracted data from the global burden of disease (GBD) 2021 database to evaluate MSMI burden with different measures for the whole world, 21 GBD regions and 204 countries from 1990 to 2021.SettingStudies from the GBD 2021 database generated by population-representative data sources identified through a literature review and research collaborations were included.ParticipantsPatients with an MSMI diagnosis.OutcomesTotal nu

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Muller, Matthew D., Zhaohui Gao, Patrick M. McQuillan, Urs A. Leuenberger, and Lawrence I. Sinoway. "Coronary responses to cold air inhalation following afferent and efferent blockade." American Journal of Physiology-Heart and Circulatory Physiology 307, no. 2 (2014): H228—H235. http://dx.doi.org/10.1152/ajpheart.00174.2014.

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Cardiac ischemia and angina pectoris are commonly experienced during exertion in a cold environment. In the current study we tested the hypotheses that oropharyngeal afferent blockade (i.e., local anesthesia of the upper airway with lidocaine) as well as systemic β-adrenergic receptor blockade (i.e., intravenous propranolol) would improve the balance between myocardial oxygen supply and demand in response to the combined stimulus of cold air inhalation (−15 to −30°C) and isometric handgrip exercise (Cold + Grip). Young healthy subjects underwent Cold + Grip following lidocaine, propranolol, an

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Tauriainen, Milla-Maria, Susanne Csader, Maria Lankinen, et al. "PNPLA3 Genotype and Dietary Fat Modify Concentrations of Plasma and Fecal Short Chain Fatty Acids and Plasma Branched-Chain Amino Acids." Nutrients 16, no. 2 (2024): 261. http://dx.doi.org/10.3390/nu16020261.

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The GG genotype of the Patatin-like phosphatase domain-containing 3 (PNPLA3), dietary fat, short-chain fatty acids (SCFA) and branched-chain amino acids (BCAA) are linked with non-alcoholic fatty liver disease. We studied the impact of the quality of dietary fat on plasma (p) and fecal (f) SCFA and p-BCAA in men homozygous for the PNPLA3 rs738409 variant (I148M). Eighty-eight randomly assigned men (age 67.8 ± 4.3 years, body mass index 27.1 ± 2.5 kg/m2) participated in a 12-week diet intervention. The recommended diet (RD) group followed the National and Nordic nutrition recommendations for fa

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Rezazadeh, Mahboubeh, Jaber Emami, Abolfazl Mostafavi, et al. "A Rapid and Sensitive HPLC Method for Quantitation of Paclitaxel in Biological Samples using Liquid-Liquid Extraction and UV Detection: Application to Pharmacokinetics and Tissues Distribution Study of Paclitaxel Loaded Targeted Polymeric Micelles in....." Journal of Pharmacy & Pharmaceutical Sciences 18, no. 5 (2015): 647. http://dx.doi.org/10.18433/j3rp6z.

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A simple, rapid, and sensitive reversed-phase HPLC method was developed and validated for determination of paclitaxel (PTX) in plasma, various organs and tumor tissues of tumor-bearing mice. Tissue specimens of liver, kidneys, spleen, lungs, heart and tumor were separately homogenized in normal saline. Plasma or tissue homogenate (250 µl) containing PTX and internal standard (diazepam) were extracted by diethyl ether (6 ml). The separation was achieved on a µ-Bondapak C18 HPLC column using sodium acetate buffer solution (0.01 M)/acetonitrile (58/42 v/v) at pH 5 ± 0.1 and flow rate of 1.9 mL/mi

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32

Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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Katz, A., K. Sahlin, and J. Henriksson. "Muscle ammonia metabolism during isometric contraction in humans." American Journal of Physiology-Cell Physiology 250, no. 6 (1986): C834—C840. http://dx.doi.org/10.1152/ajpcell.1986.250.6.c834.

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The changes in ammonia (NH3) and amino acid contents in human skeletal muscle during isometric exercise (2/3 maximal voluntary contraction force) to fatigue have been investigated. Biopsies from musculus quadriceps femoris were obtained at rest, fatigue, and 1 and 4 min recovery. Muscle NH3 (n = 9) increased from 1.3 +/- 0.3 (mean +/- SE) mmol/kg dry muscle (dm) at rest to 3.6 +/- 0.6 at fatigue (P less than 0.01) and remained elevated during recovery, whereas the lactate increase after contraction decreased rapidly during recovery. Total adenine nucleotide (TAN) content decreased from 28.7 +/

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34

Swampillai, A., M. Williams, M. Osborne, et al. "A single-center study of the utility of squamous cell carcinoma antigen (SCCAg) levels in epidermoid carcinoma of the anal canal and margin (ECACM) treated with chemoradiation (CRT)." Journal of Clinical Oncology 27, no. 15_suppl (2009): 4117. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4117.

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4117 Background: SCCAg is a tumour marker expressed by ECACM, measured by microparticle enzyme immunoassay; normal range 0–150ng/dl. Methods: This retrospective study examined the role of SCCAg in staging and prediction of recurrence in 195 patients (pts); 76 m:119 f with ECACM treated 1997–2007. All 195 were treated with CRT- (50.4Gy in 28 fractions of 1.8 Gy with 5-fluorouracil (5-FU) + mitomycin (MMC). Radiotherapy comprised the schedule of the UK Anal cancer Trial (ACT II). Variations included 5FU and cisplat, and capecitabine. 30 had neo-adjuvant chemotherapy followed by CRT and 3 pts had

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Rakowski, R. F., D. C. Gadsby, and P. De Weer. "Stoichiometry and voltage dependence of the sodium pump in voltage-clamped, internally dialyzed squid giant axon." Journal of General Physiology 93, no. 5 (1989): 903–41. http://dx.doi.org/10.1085/jgp.93.5.903.

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The stoichiometry and voltage dependence of the Na/K pump were studied in internally dialyzed, voltage-clamped squid giant axons by simultaneously measuring, at various membrane potentials, the changes in Na efflux (delta phi Na) and holding current (delta I) induced by dihydrodigitoxigenin (H2DTG). H2DTG stops the Na/K pump without directly affecting other current pathways: (a) it causes no delta I when the pump lacks Na, K, Mg, or ATP, and (b) ouabain causes no delta I or delta phi Na in the presence of saturating H2DTG. External K (Ko) activates Na efflux with Michaelis-Menten kinetics (Km

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36

Jayaprakash, Priyamvada, Meghan Rice, Krithikaa Rajkumar Bhanu, et al. "622 Disrupted oxygen supply and tumor hyper- oxygen consumption contribute independently to prostate cancer immune privilege." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A652. http://dx.doi.org/10.1136/jitc-2021-sitc2021.622.

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BackgroundDespite the success of immunotherapy in immune-infiltrated ”hot” tumors like melanoma, ”cold” tumors like prostate cancer remain unresponsive [1,2,3]. We find that these tumors harbor regions of hypoxia that act as islands of immune privilege that exclude T cells, while retaining immunosuppressive myeloid cells. Targeting hypoxia using the hypoxia-activated prodrug, TH-302 (Evofosfamide) reduced hypoxic regions and co-operated with immune checkpoint blockade (anti-CTLA-4+anti PD-1) to drive tumor regression in transplantable and spontaneous murine prostate tumors [4]. In a Phase I cl

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Rubanenko, Olesya A., O. V. Fatenkov, S. M. Khokhlunov, A. P. Semagin, D. V. Kuznetsov, and L. V. Limareva. "The influence of omega-3 polyunsaturated fatty acids on atrial fibrillation development after surgical myocardial revascularisation." Clinical Medicine (Russian Journal) 95, no. 8 (2017): 693–99. http://dx.doi.org/10.18821/0023-2149-2017-95-8-693-699.

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Aim. To estimate the influence of short-term omega-3 polyunsaturated fatty acids (PUFA) treatment on the development of new cases of atrial fibrillation (AF) in patients with coronary artery disease after coronary artery bypass grafting (CABG) with the detection of indicators of inflammation, oxidative stress, myocardial injury or dysfunction. Material and methods. The patients did not receive statins at the stage of out-patient treatment. Interleukin (IL)-6, IL-8, IL-10, C-reactive protein (CRP), fibrinogen, troponin, NT-proBNP, superoxide dismutase (SOD), myeloperoxidase (MPO) levels were me

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Zhao, Dong, Wei Feng, Wei Zhao, Xin Yuan, and Chuangshi Wang. "Impact of Overt Hypothyroidism on Early Outcomes of Coronary Artery Surgery." Heart Surgery Forum 24, no. 5 (2021): E870—E876. http://dx.doi.org/10.1532/hsf.4057.

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Background: The association between preoperative overt hypothyroidism and early outcomes after coronary artery bypass grafting (CABG) is unclear. This study aimed to evaluate the influence of overt hypothyroidism on the outcomes of CABG. Methods: The series included 189 overt hypothyroid patients, who underwent CABG at Fuwai Hospital. These patients were 1:4 matched with 737 euthyroid patients using propensity score matching. The early postoperative outcomes were compared. Results: After propensity score matching, the incidences of impaired wound healing, reintubation, and the total complicati

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Kang, Hyun-Cheol, Jin Ho Kim, and Eui Kyu Chie. "Respiratory-gated magnetic resonance image guided radiation therapy for hepatocellular carcinoma: A pilot study." Journal of Clinical Oncology 38, no. 4_suppl (2020): 532. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.532.

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532 Background: Hypofractionated RT has shown encouraging results in hepatocellular carcinoma (HCC) patients. However, HCC adjacent to the gastrointestnal (GI) tract should be carefully treated using the high-precision irradiation technique due to risk of radiation damage. We evaluated the feasibility of a respiratory-gated magnetic resonance image guided radiation therapy (RgMRg-RT) for hepatocellular carcinoma (HCC). Methods: Thirty-three patients with HCC underwent RgMRg-RT in our hospital from 2015 to February 2019, including patients with Child-Pugh A/B7 cirrhosis and unresectable tumors

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Colombo, Tiziano, Claudio Russo, Guglielma Rita Ciliberto, et al. "Tricuspid Regurgitation Secondary to Mitral Valve Disease: Tricuspid Annulus Function as Guide to Tricuspid Valve Repair." Cardiovascular Surgery 9, no. 4 (2001): 369–77. http://dx.doi.org/10.1177/096721090100900410.

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Methods. A prospective analysis was performed on 50 patients (pts) with rheumatic mitral disease and associate secondary tricuspid insufficiency who underwent mitral valve replacement from January 1995 to December 1998. Surgical indication to tricuspid annuloplasty was considered in patients with echocardiographic tricuspid annulus diameter >21 mm/m2, regardless semiquantitative evaluation of tricuspid insufficiency. De Vega annuloplasty was performed in 33 out of 50 patients. Results. Hospital mortality was 2.0% (CL 0.3–3.6). The follow up of the discharged patients ranged from 3 to 48 mon

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Headrick, J. P. "Impact of aging on adenosine levels, A1/A2 responses, arrhythmogenesis, and energy metabolism in rat heart." American Journal of Physiology-Heart and Circulatory Physiology 270, no. 3 (1996): H897—H906. http://dx.doi.org/10.1152/ajpheart.1996.270.3.h897.

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Adenosine formation, energy metabolism, A1 and A2 responses, and arrhythmogenesis were examined in hearts from young adult (4-6 mo) and aged rats (18-20 mo). Aging reduced heart rate from 308 +/- 9 to 252 +/- 13 beats/min and myocardial O2 consumption (MVO2) from 127 +/- 5 to 103 +/- 4 microliters O2.min-1.g-1 and increased atrioventricular conduction time from 47 +/- 4 to 61 +/- 8 ms. Differences in intrinsic rate were reduced by A1 antagonism with 10 microM 8-cyclopentyl-1,3-dimethylxanthine. Adenosine efflux and cardiac microdialysate [adenosine] in isovolumically working hearts increased t

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42

Ibrahim, S. and Nafi’u, S.A. "Macroinvertebrates as Indicators of Water Quality in Thomas Dam, Dambatta, Kano State, Nigeria." UMYU Journal of Microbiology Research (UJMR) 2, no. 1 (2017): 61–71. http://dx.doi.org/10.47430/ujmr.1721.010.

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A study on the water quality assessment using benthic macroinvertebrates in Thomas Dam, Dambatta Kano State was carried out fortnightly for a period of four months (January – April, 2016). Four sampling sites were chosen based on the vegetation pattern and impact of human activities on the dam. Modified Ekman grab sampler was used for benthic Macroinvertebrates collection and identified using standard identification keys. Standard methods were used to determine the physicochemical parameters. The mean range of physicochemical parameters studied were; water temperature (19.6±1.12 - 23.0±1.00 °C

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Hvass, Lars, Marcel Martin, Anne Clausen, et al. "Abstract 592: Theranostic 68Ga/131I compounds for PSMA targeted radioligand therapy." Cancer Research 85, no. 8_Supplement_1 (2025): 592. https://doi.org/10.1158/1538-7445.am2025-592.

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Abstract Introduction: Prostate cancer is the most common cancer in men and continues to be a common cause of cancer related death. With progression to castration resistant metastatic prostate cancer, treatment options are scarce. Radioligand therapy has emerged as a successful treatment for these patients, significantly prolonging survival when other treatments fail. Thus far, approved PSMA targeting radiopharmaceuticals mainly use DOTA-based precursors to chelate gallium-68 for diagnosis and lutetium-177 for therapy. Here we suggest a gallium-68/iodine-131 theranostic pair as an alternative

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Lai, Zhicheng, Zefeng Du, Anna Kan, Li Xu, MinKe He, and Ming Shi. "Hepatitis B virus reactivation in hepatocellular carcinoma patients undergoing immune checkpoint inhibitor and concurrent antiviral prophylaxis agents: A prospective observational study." Journal of Clinical Oncology 43, no. 16_suppl (2025): 4127. https://doi.org/10.1200/jco.2025.43.16_suppl.4127.

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4127 Background: Immune checkpoint inhibitors (ICIs) have been recommended for the treatment of advanced hepatocellular carcinoma (HCC). However, due to the potential hazard of hepatitis B virus (HBV) reactivation, all ICI-related phase 3 studies had strict restrictions on HBV-DNA load (e.g., < 500IU/ml). Meanwhile, delayed immunotherapy may lead to poor prognosis for patients with high HBV-DNA load. This study aims to compare the HBV reactivation between HCC patients with low or high HBV-DNA load undergoing ICIs and concurrent antiviral prophylaxis agents. Methods: This prospective, observ

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Niedzielski, A., E. Villaver, M. Adamów, K. Kowalik, A. Wolszczan, and G. Maciejewski. "Tracking Advanced Planetary Systems (TAPAS) with HARPS-N." Astronomy & Astrophysics 648 (April 2021): A58. http://dx.doi.org/10.1051/0004-6361/202037892.

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Context. We present the current status of and new results from our search for exoplanets in a sample of solar-mass evolved stars observed with the HARPS-N and the 3.6 m Telescopio Nazionale Galileo (TNG), and the High-Resolution Spectrograph (HRS) and the 9.2 m Hobby-Eberly Telescope (HET). Aims. The aim of this project is to detect and characterize planetary-mass companions to solar-mass stars in a sample of 122 targets at various stages of evolution from the main sequence to the red giant branch, mostly subgiants and giants, selected from the Pennsylvania-Toruń Planet Search sample, and to u

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Trentin, F., C. Tani, A. Cauli, et al. "AB0558 ANIFROLUMAB IN REFRACTORY SYSTEMIC LUPUS ERYTHEMATOSUS: A REAL-LIFE, MULTICENTER STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1476. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3552.

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BackgroundAnifrolumab (ANI) is a monoclonal antibody to the type I interferon receptor recently approved by EMA as an add-on therapy for the treatment of moderate to severe SLE. As of this writing, real world data on its use are still lacking.ObjectivesTo depict the clinical phenotype of refractory SLE patients treated with ANI. To evaluate short-term effectiveness and safety of ANI in clinical practice.MethodsMulticenter prospective cohort study on adult patients with SLE treated with ANI for compassionate use. Demographic data, clinical and treatment history, and SLICC Damage Index (SDI) wer

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Pérez-Ros, Pilar, Rafael Vila-Candel, Lourdes López-Hernández, and Francisco Miguel Martínez-Arnau. "Nutritional Status and Risk Factors for Frailty in Community-Dwelling Older People: A Cross-Sectional Study." Nutrients 12, no. 4 (2020): 1041. http://dx.doi.org/10.3390/nu12041041.

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Objective: This study aims to assess the relationship that frailty has with nutritional status and functional risk factors in community-dwelling older adults. Methods: Cross-sectional study in community-dwelling older people, independent for walking and without impaired cognition. Frailty was assessed by Fried criteria. Nutritional status was analyzed by the Mini Nutritional Assessment Short Form (MNA-SF), biochemical markers (albumin, total proteins, cholesterol, lymphocytes, and hemoglobin); and anthropometric parameters (body mass index [BMI], body fat percentage, handgrip, and perimeters).

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Thornton, James Douglas, Tyler Varisco, Harshil Patel, et al. "Characterising incident opioid use among incident users of prescription sedative hypnotics: A national cohort study." BMJ Open 14, no. 5 (2024): e082339. http://dx.doi.org/10.1136/bmjopen-2023-082339.

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ObjectiveTo evaluate co-prescribing of sedatives hypnotics and opioids.DesignRetrospective study evaluating the association of patient characteristics and comorbidities with coprescribing.Setting and participantsUsing the national Merative MarketScan Database between 2005 and 2018, we identified patients who received an incident sedative prescription with or without subsequent, incident opioid prescriptions within a year of the sedative prescription in the USA.Outcome measuresCoprescription of sedative-hypnotics and opioids.ResultsA total of 2 632 622 patients (mean (SD) age, 43.2 (12.34) year

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Paz-Ares, Luis G., Bonne Biesma, David Heigener, et al. "Phase III, Randomized, Double-Blind, Placebo-Controlled Trial of Gemcitabine/Cisplatin Alone or With Sorafenib for the First-Line Treatment of Advanced, Nonsquamous Non–Small-Cell Lung Cancer." Journal of Clinical Oncology 30, no. 25 (2012): 3084–92. http://dx.doi.org/10.1200/jco.2011.39.7646.

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Purpose This trial evaluated the efficacy and safety of sorafenib plus gemcitabine/cisplatin in chemotherapy-naive patients with unresectable stage IIIB to IV nonsquamous non–small-cell lung cancer (NSCLC). Patients and Methods Between February 2007 and March 2009, 904 patients were randomly assigned to daily sorafenib (400 mg twice a day) or matching placebo plus gemcitabine (1,250 mg/m2 per day on days 1 and 8) and cisplatin (75 mg/m2 on day 1) for up to six 21-day cycles. Because of safety findings from the Evaluation of Sorafenib, Carboplatin and Paclitaxel Efficacy in NSCLC (ESCAPE) trial

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Paoin, Pontip, Pichita Prasongvej, Athita Chanthasenanont, Titchayakorn Niumpradit, Densak Pongrojpaw, and Komsun Suwannarurk. "Efficacy of Music Therapy and Zingiber officinale Roscoe Aromatherapy for Reducing Pain during the First Stage of Labor: A Randomized Controlled Trial." Siriraj Medical Journal 75, no. 10 (2023): 707–12. http://dx.doi.org/10.33192/smj.v75i10.263860.

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Objective: To study the pain-reducing effect of music therapy and aromatherapy with ginger essential oil (GEO; Zingiber officinale Roscoe) in the first stage of labor. Materials and Methods: This randomized controlled trial was conducted from May to October 2022 in the delivery room of Thammasat University Hospital in Thailand. Participants were nulliparous pregnant women who came with actual labor pain and cervical dilation of 3 cm. They were divided into three groups: control, music, and aromatherapy. The control group received intrapartum care according to hospital guidelines, while partici

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