Статті в журналах з теми "623.452 6"
Щоб переглянути інші типи публікацій з цієї теми, перейдіть за посиланням: 623.452 6.
Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями
Ознайомтеся з топ-50 статей у журналах для дослідження на тему "623.452 6".
Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.
Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.
Переглядайте статті в журналах для різних дисциплін та оформлюйте правильно вашу бібліографію.
1
Fesenmeier, Ludwig. "Paul Videsott. Padania scrittologica. Analisi scrittologiche e scrittometriche di testi in italiano settentrionale antico dalle origini al 1525." Linguistica 51, no. 1 (December 31, 2011): 385–89. http://dx.doi.org/10.4312/linguistica.51.1.385-389.
Анотація:
Il presente volume, versione rimaneggiata e tradotta della Habilitationsschrift dell’autore,1 mira a “delineare l’evoluzione della lingua scritta volgare non letteraria dell’Italia settentrionale” (7), adoperando un metodo sviluppato, e variamente applica- to, soprattutto da Hans Goebl. L’opera si divide in quattro capitoli, preceduti da due prefazioni (1-6)2 e seguiti dalla “Bibliografia” (423-454), dalle “Cartine coropletiche” (455-620), e da due indici (621-624).
2
Tsay, J. G., R. S. Chen, W. L. Wang, and B. C. Weng. "First Report of Anthracnose on Cucurbitaceous Crops Caused by Glomerella magna in Taiwan." Plant Disease 94, no. 6 (June 2010): 787. http://dx.doi.org/10.1094/pdis-94-6-0787a.
Анотація:
During the summer and fall of 2006, leaf anthracnose samples were collected from fields of cucumber (Cucumis sativus L.), calabash gourd (Lagenaria siceraria (Molina) Standley), and luffa (Luffa cylindrica (L.) M. Roem.) in southern Taiwan. On cucumber leaves, spots start as water-soaked areas and expand into brown spots. Leaf lesions on calabash gourd and luffa begin as water soaked and then become light brown-to-reddish spots. Centers of lesions sometimes fall out; giving infected leaves a shot-hole appearance. Small pieces (approximately 2 × 2 mm) of diseased leaf tissue from margins of individual lesions were surface disinfected in 1% sodium hypochlorite solution for 1 min, rinsed in sterile water, plated on water agar, and incubated at 25°C. After 4 days, mycelium was isolated, transferred to potato dextrose agar (PDA), and then incubated at 25°C in a 12-h light/darkness regimen. Fast-growing colonies on PDA were white to orange or pink with abundant acervuli but no perithecium. One-celled conidia were ovoid to oblong and 12 to 20 × 4 to 6 (15.9 × 5.0) μm. The morphological traits were identical to those of Colletotrichum magna (teleomorph Glomerella magna Jenkins & Winstead) and clearly distinct from those of C. orbiculare (Berk. & Mont.) Arx (synonym C. lagenarium (Pass.) Ellis & Halst. (conidia were mostly oblong, measuring 7 to 11 × 2 to 6 [9.3 × 4.2] μm, with slow-growing gray colonies) (2,3). Koch's postulates were performed to verify that the isolates were capable of causing anthracnose on cucurbitaceous crops. Pathogenicity tests were conducted in the greenhouse at 25°C under natural daylight conditions. Isolate C0604 was grown on PDA for 14 days and a spore suspension was made (106 spores/ml). Three 14-day-old seedlings at the two- to three-leaf stage of muskmelon (Cucumis melo L. var. reticulatus Naud., cv. Sapphire), squash (Cucurbita moschata Duch., cv. Achen), calabash gourd (cv. Huapu), and luffa (cv. 623) were sprayed with the spore suspension and then covered with plastic bags. Control treatments were sprayed with sterile water. After 2 days, the bags were removed. Typical anthracnose symptoms developed on all inoculated seedlings 7 days after inoculation. G. magna was reisolated from inoculated leaves following the protocol used for the original isolation. Control seedlings developed no symptoms. To confirm the identity of the fungus, PCR amplification and DNA sequencing of the internal transcribed spacer 1 (ITS1)-5.8S-ITS2 of rRNA gene of the isolate C0604 was performed by using ITS1/ITS4 as the PCR and sequencing primers. Sequence analysis of the 558-bp PCR product (GenBank Accession No. GU358453) showed 100% identity to the rRNA sequence of G. magna (GenBank Accession No. DQ003103) (1). PCR amplification of the ITS region was also carried out using species-specific primer GmF (5′- GTG AAC ATA CCT CAA ACG TTG CC -3′)/GmR (5′- GGA GGG TCC GCC ACT GTA TTT CG -3′) designed in this study. A DNA fragment of approximately 378 bp was amplified from nine isolates of G. magna, whereas no amplification products were obtained from reference cultures of C. gloeosporioides (Penz.) Penz. & Sacc. and C. orbiculare. To our knowledge, this is the first report of G. magna causing anthracnose on cucurbitaceous crops in Taiwan. References: (1) M. Du et al. Mycologia 97:641, 2005. (2) S. F. Jenkins, Jr. and N. N. Winstead. Phytopathology 54:452, 1964. (3) T. A. Zitter et al., eds. Compendium of Cucurbit Diseases. The American Phytopathological Society, St. Paul, MN, 1996.
3
Садовников, С. И., та А. И. Гусев. "Влияние температуры на размер частиц и рекристаллизацию нанопорошков сульфида серебра". Физика твердого тела 60, № 7 (2018): 1303. http://dx.doi.org/10.21883/ftt.2018.07.46113.341.
Анотація:
AbstractThe recrystallization of silver sulfide Ag_2S nanoparticles has been studied and the range of the thermal stability of the nanoparticle sizes has been determined. Nanopowders Ag_2S with particle sizes of 45–50 nm were obtained by chemical deposition from aqueous solutions. To study the thermal stability of the Ag_2S nanoparticle sizes, the nanocrystalline powders have been annealed in a vacuum of 0.01 Pa on heating from room temperature to 493 K and in argon at 623 K. Annealing up to a temperature of 453 K leads to insignificant nanoparticle growth and annealing of microstrains, which allows one to consider this temperature range as the region of thermal stability of the silver sulfide nanostate. The temperature range from 450 to 900 K, in which the particle size increases by a factor of 3–6, corresponds to the temperature of collective recrystallization of the silver sulfide nanopowder.
4
Serge, Gagnon André Yelle. "622 PB 442 THERMAL WEED CONTOL FOR VEGETABLE PRODUCTION." HortScience 29, no. 5 (May 1994): 521d—521. http://dx.doi.org/10.21273/hortsci.29.5.521d.
Анотація:
In the summer of 1992, a 4-year research program on the utilisation of propane in agriculture was initiated between ICG Propane and Lava1 University. Experiments were conducted to evaluate the effects of propane burners on weed control as a pre-establishment treatment. The data indicate that the efficiency of weed control is related to tractor speed and gas pressure. When weed height is between 1 and 2 centimetres, most of the heat treatments were as effective as those with the herbicide paraquat. The best and most economical heat treatment was at a tractor speed of 6 Km-hr and a gas pressure of 65 PSI. With larger weeds, efficiency increased with reduces tractor speed and increased gas pressure. In addition, high intensity treatments provided excellent control on broadleaf weeds but were less efficient on grass species. A preliminary economical evaluation showed that propane burners are competitive with chemical herbicides and large-scale commercial trials are planned for summer 1994.
5
Clark, Stephen, Michael Sidlak, Amy Mathers, Melinda Poulter, and James Platts-Mills. "Clinical Yield of Routine Use of Molecular Testing for Adult Outpatients with Diarrhea." Open Forum Infectious Diseases 4, suppl_1 (2017): S33. http://dx.doi.org/10.1093/ofid/ofx162.080.
Анотація:
Abstract Background Molecular diagnostics for enteropathogens increase yield while reducing turnaround time. However, many pathogens do not require specific therapy, and the cost is substantial. Methods We reviewed the use of the FilmArray GI Panel (BioFire Diagnostics, Salt Lake City, Utah) in adult outpatients at the University of Virginia and identified clinical features that could limit testing without reducing yield. We defined yield as (a) detection of a pathogen, (b) detection of a pathogen for which antimicrobial therapy is indicated, or (c) detection of a pathogen that can change management, which additionally included viral pathogens in immunocompromised patients. Results Between March 23, 2015 and February 25, 2016, we reviewed 452 tests from adult outpatients with diarrhea. A pathogen was detected in 88/452 (19.5%). The most common pathogens were: enteropathogenic E. coli (36; 8.0%), norovirus (17; 3.8%), Campylobacter (7, 1.5%), enteroaggregative E. coli (6, 1.3%), Giardia (6; 1.3%), and sapovirus (5; 1.1%). Based on clinical guidelines, antimicrobial treatment was clearly indicated for 19/452 subjects (4.2%). Limiting testing to patients with an additional enteric symptom (abdominal pain, nausea, vomiting, fecal urgency, tenesmus, or flatulence), a travel history, or an immunocompromising condition would reduce testing by 25.9%, with a treatable pathogen identified in 18/331 (5.4%) (sensitivity 94.7%, specificity 27.7%). Further modifying testing criteria to exclude subjects with vomiting, 18/288 (6.3%) had a treatable pathogen (sensitivity 94.7%, specificity 37.3%), and a pathogen which could change management was detected in 28/288 (9.7%) (sensitivity 96.6%, specificity 38.5%). Excluding immunocompromised subjects or those with a travel history, American College of Gastroenterology guidelines for testing were met by 293/348 (84.2%) with a documented duration of diarrhea, and a treatable pathogen was detected in 8/293 (2.7%) vs. 3/55 (5.5%) who did not meet testing guidelines. Conclusion Testing could be reduced by 36.3% without decreasing clinical yield by limiting testing to patients with diarrhea with an additional enteric symptom and no history of vomiting, a travel history, or an immunocompromising condition. ACG guidelines did not improve testing efficiency. Disclosures All authors: No reported disclosures.
6
Morgan, Gareth J., Faith E. Davies, Walter M. Gregory, Sue E. Bell, Alex J. Szubert, Nuria Navarro-Coy, Mark T. Drayson, et al. "Thalidomide Maintenance Significantly Improves Progression-Free Survival (PFS) and Overall Survival (OS) of Myeloma Patients When Effective Relapse Treatments Are Used: MRC Myeloma IX Results." Blood 116, no. 21 (November 19, 2010): 623. http://dx.doi.org/10.1182/blood.v116.21.623.623.
Анотація:
Abstract Abstract 623 Background: Although a meta-analysis has suggested that a consistent PFS benefit is seen with maintenance thalidomide therapy in multiple myeloma (MM) patients, the impact on OS remains unclear (Hicks LK, et al. Cancer Treat Rev 2008;34:442-452). This could be due to a lack of effect, differing biological subgroups in relatively small studies with short follow-up, or lack of effective relapse treatment. Aims: The study was set up to evaluate the effect of thalidomide maintenance therapy in newly diagnosed MM patients aged ≥ 18 years with OS and PFS as end points, and to examine differential effects in fluorescence in situ hybridization (FISH) identified molecular subgroups. Methods: Following induction treatment in an intensive pathway for younger fitter patients and a non-intensive pathway for the remaining patients, eligible patients were randomized to open-label thalidomide maintenance until progression (50 mg/day escalating to 100 mg/day after 4 weeks assuming good tolerance) or no maintenance. Patients of all ages were included in the randomization. FISH was performed using standard approaches. Adverse FISH groups were defined as any of t(4;14), t(14;16), t(14;20), 1q+, 17p−, or 1p32− (in the intensive pathway only); the remainder were defined as favorable. Results: Overall, 820 patients were eligible of which 818 were evaluable. Median patient age was 65 years (range, 31−89). Median follow-up from maintenance was 38 months (range 12−66 months). Median time on maintenance was 7 months (range 0−50 months). Maintenance thalidomide significantly improved PFS, with a difference between the curves of 13% (95% confidence interval [CI] 6%−20%) established by 24 months and maintained till the current maximum follow-up at 66 months (hazard ration [HR] 1.36; 95% CI 1.15−1.61; logrank P < 0.001). However, in the initial analysis there was no apparent impact on OS (P = 0.40). These findings were consistent regardless of prior intensive or non-intensive induction treatment. At 66 months follow-up, a PFS benefit was seen in the favorable FISH group (P = 0.004) with no effect on OS (P = 0.6). In the adverse FISH group there was no effect on PFS (P = 0.48) and a negative effect on OS (P = 0.009). Subsequently, we evaluated the effect of relapse treatment on outcomes and used this data in a mathematical model to determine if OS benefit would have accrued from the prolonged PFS if all patients had received effective treatment at relapse. A total of 523 patients have progressed to date and of these, 47% received thalidomide as initial relapse treatment (either as a single agent or in combination), 30% received novel agents (either bortezomib or lenalidomide), and 27% received alkylating agents or steroids. Median survival after progression was significantly worse in patients who received thalidomide maintenance than those who did not (P < 0.005); this could, at least partly, be attributed to patients who received thalidomide at progression. In those patients, the median OS after progression was significantly greater in the no maintenance group versus the thalidomide maintenance group (P = 0.004). Among patients treated with novel agents at progression, prior thalidomide maintenance therapy had no impact on OS and these patients were effectively salvaged. The mathematical model employed to examine the effect of effective salvage therapy at progression suggested that a significant survival benefit of 5.5% at 3-years in favor of thalidomide maintenance would have accrued if all patients had received effective therapy at progression (HR 0.77; 95% CI 0.60–0.99; P = 0.04). Next, we examined whether continuous thalidomide therapy was associated with a consolidation or maintenance effect. Upgrading of response with thalidomide maintenance was not common. Importantly, there was no difference in response over time between maintenance therapy and no maintenance. In contrast to what has been reported previously, these findings suggest a maintenance effect. Conclusions: Maintenance thalidomide significantly improves PFS and if effective relapse treatment is available this translates into an OS advantage. The median duration of maintenance thalidomide therapy of 7 months in the present study was short. The clinical impact of maintenance would be improved if patients could remain on therapy for longer, suggesting that the use of other agents such as lenalidomide, with better tolerability profiles, may produce better results. Disclosures: Off Label Use: THALOMID (thalidomide) in combination with dexamethasone is indicated for the treatment of patients with newly diagnosed multiple myeloma. Davies:Celgene: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Ortho Biotech: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Novartis: Membership on an entity's Board of Directors or advisory committees.
7
Cooke, A. S. "Book Review: Organotin, edited by M.A. Champ and P.F. Seligman, Chapman and Hall, London, 1996. 623 pp. Price: £195. ISBN 0 412 58240 6." Aquatic Conservation: Marine and Freshwater Ecosystems 8, no. 2 (March 1998): 309–10. http://dx.doi.org/10.1002/(sici)1099-0755(199803/04)8:2<309::aid-aqc278>3.0.co;2-e.
8
Klein, Y. Maximilian, Alessandro Prescimone, Edwin C. Constable, and Catherine E. Housecroft. "Manipulating connecting nodes through remote alkoxy chain variation in coordination networks with 4′-alkoxy-4,2′:6′,4′′-terpyridine linkers." CrystEngComm 17, no. 34 (2015): 6483–92. http://dx.doi.org/10.1039/c5ce01115a.
Анотація:
A switch from a (6,3) to (4,4) net results from lengthening the chain in 4′-alkoxy-4,2′:6′,4′′-terpyridines in reactions with Cd(NO3)2·4H2O; the assembly can be switched to a 1D-ladder if lower amounts of ligand are available.
9
Dadalova, A., E. Vasilenko, R. Samigullina та V. Mazurov. "AB0712 THE INCIDENCE OF SARS-СOV-2 INFECTION IN PATIENTS WITH RHEUMATIC DISEASES ON THERAPY BIOLOGICAL DISEASE MODIFYING ANTIRHEUMATIC DRUGS". Annals of the Rheumatic Diseases 80, Suppl 1 (19 травня 2021): 1387.3–1388. http://dx.doi.org/10.1136/annrheumdis-2021-eular.4323.
Анотація:
Background:At the moment, a highly relevant issue is the course of SARS-CoV-2 infection in patients with rheumatic pathology, especially, those receiving therapy with biological disease modifying antirheumatic drugs.Objectives:of the current study to assess the prevalence and course of SARS-CoV-2 infection in patients receiving various biological disease modifying antirheumatic drugs.Methods:to assess the severity of the course of SARS-CoV-2, discharged epicrisis from hospitals or the conclusion of computed tomography were used. The average age of the patients ranged from 41.4 + 11.6 years. In the evaluated sample, 47 patients (49.47%) were males. Among the infected of SARS-CoV-2 were patients with rheumatoid arthritis - 45 (47.4%), spondyloarthritis - 39 (41.1%), systemic connective tissue diseases - 11 (11.5%).Results:Since March 2020, among the 1319 patients with rheumatic diseases observed at the St. Petersburg Center of therapy biological disease modifying antirheumatic drugs, 95 patients (7,2%) had SARS-CoV-2 infection. In 57,9% (55 patients) there was a mild course of infection, in 35,8% of cases (34 patients) - a moderate course, in 6,3% (6 patients) - a severe course. Inpatient treatment was received by 29,5% (28 patients). A favorable outcome was noted in 95.8%, and a lethal outcome in 4,2%. The use of interleukin-6 inhibitors was required in 2,1% of patients (2) due to the development of a cytokine storm. The structure of the received biological therapy in the severity of the course is shown in Table 1.Table 1.The structure of the received biological therapy in the severity of the course SARS-CoV-2 infectionMild courseCT-1 (<25%)CT-2 (25-50%)CT-3 (50-75%)CT-4 (>75%)TNF-α inhibitors, n (%)30 (31,6)11 (11,6)7 (7,3)3 (3,2)0 (0,0)anti B-cell therapy (rituximab), n (%)2 (2,1)1 (1,1)2 (2,1)1 (1,1)2 (2,1)Abatacept, n (%)3 (3.2)0 (0,0)2 (2,1)0 (0,0)0 (0,0)Janus kinase inhibitors, n (%)5 (5,3)1 (1,1)1 (1,1)0 (0,0)0 (0,0)Interleukin-6 inhibitors, n (%)6 (6,3)0 (0,0)0 (0,0)0 (0,0)0 (0,0)Interleukin-17 inhibitors, n (%)8 (8,4) 2 (2,1) 2 (2,1)0 (0,0)0 (0,0)Other, n (%)1 (1,1)4 (4,2)1 (1,1)0 (0,0)0 (0,0)Among 95 infected patients, who were observed in the center, 51 received therapy with TNF-α inhibitors (8.5% of the total number of patients receiving therapy), 8 - rituximab therapy (2.7%), 5 - abatacept (6.3%), 7 - Janus kinase inhibitors (0.9%), 6 – interleukin-6 inhibitors (9.2), 12 - interleukin -17 inhibitors (14.1%), 6 patients treated with other drugs (10%).Conclusion:Taking into account the SARS-CoV-2 pandemic, further study of the course of infection in patients with rheumatic diseases, including those receiving biological therapy, is required. More information is also needed on the safety and efficacy of vaccination in this patient population.Disclosure of Interests:None declared
10
Glockling, F. "Book review: Organotin: environmental fate and effects, M A Champ and P F Seligman (eds), Chapman and Hall, London, 1996. 623 pages, �195.00. ISBN 0-412-58240-6." Applied Organometallic Chemistry 11, no. 9 (September 1997): 755–56. http://dx.doi.org/10.1002/(sici)1099-0739(199709)11:9<755::aid-aoc646>3.0.co;2-7.
11
Connor, Thomas, Daniel Stern, Eduardo Bañados, and Chiara Mazzucchelli. "X-Ray Evidence Against the Hypothesis that the Hyperluminous z = 6.3 Quasar J0100+2802 is Lensed." Astrophysical Journal Letters 922, no. 2 (November 23, 2021): L24. http://dx.doi.org/10.3847/2041-8213/ac37b5.
Анотація:
Abstract The z = 6.327 quasar SDSS J010013.02+280225.8 (hereafter J0100+2802) is believed to be powered by a black hole more massive than 1010 M ⊙, making it the most massive black hole known in the first billion years of the universe. However, recent high-resolution ALMA imaging shows four structures at the location of this quasar, potentially implying that it is lensed with a magnification of μ ∼ 450 and thus its black hole is significantly less massive. Furthermore, for the underlying distribution of magnifications of z ≳ 6 quasars to produce such an extreme value, theoretical models predict that a larger number of quasars in this epoch should be lensed, implying further overestimates of early black hole masses. To provide an independent constraint on the possibility that J0100+2802 is lensed, we reanalyzed archival XMM-Newton observations of the quasar and compared the expected ratios of X-ray luminosity to rest-frame UV and IR luminosities. For both cases, J0100+2802's X-ray flux is consistent with the no-lensing scenario; while this could be explained by J0100+2802 being X-ray faint, we find it does not have the X-ray or optical spectral features expected for an X-ray faint quasar. Finally, we compare the overall distribution of X-ray fluxes for known, typical z ≳ 6 quasars. We find a 3σ tension between the observed and predicted X-ray-to-UV flux ratios when adopting the magnification probability distribution required to produce a μ = 450 quasar.
12
Yan, Lin, Sneha Sundaram, and Forrest H. Nielsen. "Voluntary running of defined distances reduces body adiposity and its associated inflammation in C57BL/6 mice fed a high-fat diet." Applied Physiology, Nutrition, and Metabolism 42, no. 11 (November 2017): 1179–84. http://dx.doi.org/10.1139/apnm-2017-0285.
Анотація:
This study investigated the effect of voluntary running of defined distances on body adiposity in male C57BL/6 mice fed a high-fat diet. Mice were assigned to 6 groups and fed a standard AIN93G diet (sedentary) or a modified high-fat AIN93G diet (sedentary; unrestricted running; or 75%, 50%, or 25% of unrestricted running) for 12 weeks. The average running distance was 8.3, 6.3, 4.2, and 2.1 km/day for the unrestricted, 75%, 50%, and 25% of unrestricted runners, respectively. Body adiposity was 46% higher in sedentary mice when fed the high-fat diet instead of the standard diet. Running decreased adiposity in mice fed the high-fat diet in a dose-dependent manner but with no significant difference between sedentary mice and those running 2.1 km/day. In sedentary mice, the high-fat instead of the standard diet increased insulin resistance, hepatic triacylglycerides, and adipose and plasma concentrations of leptin and monocyte chemotactic protein-1 (MCP-1). Running reduced these variables in a dose-dependent manner. Adipose adiponectin was lowest in sedentary mice fed the high-fat diet; running raised adiponectin in both adipose tissue and plasma. Running 8.3 and 6.3 km/day had the greatest, but similar, effects on the aforementioned variables. Running 2.1 km/day did not affect these variables except, when compared with sedentariness, it significantly decreased MCP-1. The findings showed that running 6.3 kg/day was optimal for reducing adiposity and associated inflammation that was increased in mice by feeding a high-fat diet. The findings suggest that voluntary running of defined distances may counteract the obesogenic effects of a high-fat diet.
13
Eckardt, K. U., M. LeHir, C. C. Tan, P. J. Ratcliffe, B. Kaissling, and A. Kurtz. "Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels." American Journal of Physiology-Renal Physiology 263, no. 5 (November 1, 1992): F925—F930. http://dx.doi.org/10.1152/ajprenal.1992.263.5.f925.
Анотація:
To assess the role of renal innervation in O2-dependent control of erythropoietin (EPO) formation, we have determined EPO mRNA levels in both kidneys of unilaterally denervated rats and sham-operated controls using RNase protection. To investigate whether possible effects of renal nerve input are related to the type of hypoxic stimulus and the degree of stimulation, animals were studied under basal conditions, after exposure to normobaric hypoxia (8% O2, 4 h) or CO (0.1%, 4 h), and after acute hemorrhage (decrease in hematocrit from 40.8 +/- 0.5 to 12.7 +/- 0.5% within 7 h; mean +/- SE, n = 6). Serum EPO levels rose on average 22-, 49-, and 48-fold under the three stimuli and were unaffected by unilateral denervation. Renal EPO mRNA levels in unilaterally denervated animals, when expressed in arbitrary units revealed by comparison with an external standard, were 7.0 +/- 1.5 vs. 6.3 +/- 2.0 (normoxia), 432 +/- 136 vs. 451 +/- 156 (normobaric hypoxia), 971 +/- 93 vs. 930 +/- 120 (CO), and 604 +/- 170 vs. 689 +/- 203 (hemorrhagic anemia) in the intact vs. the denervated kidney (mean +/- SE, n = 3). Furthermore, there was no difference between EPO mRNA levels of either kidney of unilaterally denervated animals and levels in sham-operated controls. We conclude that renal nerve input plays no significant role in the control of the EPO gene under both basal and stimulated conditions.
14
Fabrykiewicz, Piotr, Radosław Przeniosło, and Izabela Sosnowska. "Crystal symmetry for incommensurate helical and cycloidal modulations." Acta Crystallographica Section A Foundations and Advances 77, no. 2 (March 1, 2021): 160–72. http://dx.doi.org/10.1107/s205327332100111x.
Анотація:
A classification of magnetic superspace groups compatible with the helical and cycloidal magnetic modulations is presented. Helical modulations are compatible with groups from crystal classes 1, 2, 222, 4, 422, 3, 32, 6 and 622, while cycloidal modulations are compatible with groups from crystal classes 1, 2, m and mm2. For each magnetic crystal class, the directions of the symmetry-allowed (non-modulated) net ferromagnetic moment and electric polarization are given. The proposed classification of superspace groups is tested on experimental studies of type-II multiferroics published in the literature.
15
Ford, Janet H., David W. Ayer, Qi Zhang, Jeffrey N. Carter, Elizabeth Leroux, Vladimir Skljarevski, Sheena K. Aurora, Antje Tockhorn-Heidenreich, and Richard B. Lipton. "Two randomized migraine studies of galcanezumab." Neurology 93, no. 5 (July 3, 2019): e508-e517. http://dx.doi.org/10.1212/wnl.0000000000007856.
Анотація:
ObjectiveTo evaluate changes from baseline in patient-reported outcomes for measures of functioning and disability among patients with migraine treated with galcanezumab or placebo.MethodsPatients with episodic migraine (4–14 monthly migraine headache days) were treated with either galcanezumab (Evaluation of LY2951742 in the Prevention of Episodic Migraine [EVOLVE]–1: 120 mg n = 210, 240 mg n = 208; EVOLVE-2: 120 mg n = 226, 240 mg n = 220) or placebo (EVOLVE-1 n = 425; EVOLVE-2 n = 450) during 6 months of treatment. Migraine-Specific Quality of Life Questionnaire v2.1 (MSQv2.1) measured the effect of migraine on patient functioning (physical and emotional) in 3 domains, and the Migraine Disability Assessment (MIDAS) quantified headache-related disability associated with missed or reduced productivity at work or home and social events. Both were collected at baseline and during the treatment period (MSQv2.1 = monthly; MIDAS = months 3 and 6 only).ResultsDifferences in MSQv2.1 total score least squares (LS) mean change from baseline (month 4–6) for galcanezumab (120 and 240 mg, respectively) were superior to placebo (EVOLVE-1 = 7.3 and 6.7 [both p < 0.001]; EVOLVE-2 = 8.5 and 7.3 [both p < 0.001]). Differences were similar for all domain scores (p < 0.001 for both galcanezumab doses compared with placebo), were observed as early as month 1, and were sustained for 6 months for most domains. Differences of MIDAS LS mean change from baseline (month 6) for galcanezumab (120 and 240 mg, respectively) compared with placebo were: EVOLVE-1 = −6.3 (p < 0.001) and −5.2 (p = 0.002); EVOLVE-2 = −9.2 and −8.2 (both p < 0.001).ConclusionsPatients with episodic migraine treated with galcanezumab reported significant and clinically meaningful improvements in daily functioning and decreased disability compared with patients who received placebo.Classification of evidenceThis study provides Class II evidence that for patients with migraine, galcanezumab (120 mg or 240 mg) given once monthly improved functioning and reduced disability.
16
Riffel, Ana Paula Konzen, Sinara Jardim, Marcela Ciprandi Pires, Bruna Bertagnolli, Bruna Renata Silva Corrêa, Francine Cenzi de Ré, Francis Maria Bao Zambra, Greice Lubini, Luciano Oliveira Garcia, and Bernardo Baldisserotto. "Preferred pH of silver catfish Rhamdia quelen acclimated to different pH levels." Ciência Rural 42, no. 5 (May 2012): 834–36. http://dx.doi.org/10.1590/s0103-84782012000500012.
Анотація:
The aim of this study was to investigate the preferred pH in silver catfish Rhamdia quelen acclimated to different pH. Fish were acclimated for one week at pH 4.2±0.1, 5.2±0.1, 6.3±0.1, 7.2±0.1, 8.0±0.1, and 9.0±0.1 and after this period, transferred to a polyethylene tube with a pH gradient from 3.5 to 10.0. The position of the fish in the pH gradient was observed 1, 6 and 12 hours after transference. Results indicated that acclimation to different pH did not change pH preference of silver catfish (pH 7.0-7.6), occurring only a transitory variation around 6 hours after transference. This pH preference coincides with the best pH indicated in the literature for growth of this species.
17
Willumsen, N. J., and R. C. Boucher. "Shunt resistance and ion permeabilities in normal and cystic fibrosis airway epithelia." American Journal of Physiology-Cell Physiology 256, no. 5 (May 1, 1989): C1054—C1063. http://dx.doi.org/10.1152/ajpcell.1989.256.5.c1054.
Анотація:
A method for determination of shunt resistance (Rs) and absolute conductive ion permeabilities of the apical membrane in epithelia from steady-state data is described. The method assumes that the currents are satisfactorily described by the Goldman-Hodgkin-Katz regime. Its application requires measurements of standard transepithelial electrophysiological parameters and of one or more intracellular ion activities. It is applicable under both open- and short-circuit conditions. The method was tested in an electrophysiological analysis of cultured normal and cystic fibrosis (CF) human nasal epithelium. In 15 normal and 10 CF preparations with mean transepithelial resistances of 338 and 427 omega.cm2, Rs was 412 and 623 omega.cm2, respectively. The Rs values determined with the present method were strongly correlated (r = 0.94) with those obtained with another method available in the electrophysiological literature but were as a mean 20% lower. Amiloride increased Rs by 25% in CF and by 8% in normal preparations. In normal preparations, the apical Cl permeability (PCla) was 3.6 x 10(-6) cm/s, and the apical Na permeability (PNaa) was 1.6 x 10(-6) cm/s. In CF preparations, PCla was reduced to a maximum of 2.3 x 10(-7) cm/s, whereas PNaa was increased to 6.2 x 10(-6) cm/s. The apical membrane electromotive force was -1 mV in normal and 43 mV in CF preparations. It is concluded that the method can be used to calculate Rs, apical membrane ion permeabilities, and electromotive forces from steady-state electrophysiological data.
18
Alice, Dukuzimana Marie, Bizimana Eric Gustave, Michael Habtu, Habineza Alphonse, and Rutayisire Erigene. "Prevalence and Factors Associated with Under Nutrition among Children Aged 6 to 59 Months in Ngoma District, Rwanda." Journal of Public Health International 4, no. 1 (June 18, 2021): 10–20. http://dx.doi.org/10.14302/issn.2641-4538.jphi-21-3859.
Анотація:
In Rwanda, 38% children aged 6-59 months are stunted. In Ngoma District, stunting rate is estimated at 41% among the children aged below 5 years. The study objective was to evaluate the prevalence and factors contributing to under nutrition among children aged 6- 59 months in Ngoma District. Cluster sampling was used to determine the study participants for each sector within 14 sectors by considering the sample size of 442. The WHO Anthro software version 3.2.2 was used to determine the nutritional status of the children. SPSS version 24 was used for analysis. Of 442 children participated in the study 50.9% of them were females, 24.4% were aged 15-23 months and the majority of children (89.8%) born with normal birth weight. Study findings revealed that the prevalence of under nutrition was 33.7% for stunting, 3.6% for wasting and 6.6% underweighted. Poor sanitation facility (AOR: 4.1, 95%CI: 1.83-9.3, p=0.001), poor diet (AOR: 1.9, 95%CI: 1.18-3, p=0.008) were significantly associated with stunting. Factors such as lack of hand-washing facilities (AOR: 2.5, 95% CI: 1.013-6.3, p=0.047), not eat vegetables (AOR: 4.4, 95%CI: 1.7-10.96, p=0.001), and not eat fishes (AOR: 4.1, 95%CI: 1.6-10.6, p=0.003) were associated with wasting. Short breastfeeding duration (AOR: 4.5, 95%CI: 2.9-7.2, p=0.001), not eat vegetables (AOR: 1.9; 95%CI: 1.1-3.05, p=0.008), and not eat eggs (AOR: 2, 95%CI: 1.3-2.9, p=0.001) were associated with underweight. Poor families with under-five children need continuous support that will assist them to improve nutritional status of their children.
19
Prasad, S., R. A. C. Santana, A. R. N. Campos, and V. D. Leite. "Potentiometric and conductometric studies on the system acid-isopolytungstate and the formation of lanthanum tungstates." Eclética Química 32, no. 1 (2007): 71–78. http://dx.doi.org/10.1590/s0100-46702007000100010.
Анотація:
The stoichiometry of the polyanions formed by the action of nitric acid on sodium tungstate (< 0.01M) has been studied by means of electrometric techniques involving pH-potentiometric and conductometric titrations. The well defined inflections and breaks in the titration curves provide evidence for the existence of the polyanions, para-W12O41(10-) and meta-W12O39(6-) corresponding to the ratio of H+:WO4(2-) as 7:6 and 9:6 in the pH ranges 5.7-6.0 and 3.6-4.1, respectively. The interaction of lanthanum nitrate with sodium tungstate solutions, at specific pH levels 8.0, 5.9 and 4.0 was also studied by pH and conductometric titrations, in aqueous and alcoholic media, with each of the reagents alternatively used as titrant. The electrometric experiments provide definite evidence of the formation of normal-La2O3.3WO3, para-5La2O3.36WO3 and meta-La2O3.12WO3 tungstates in the vicinity of pH 6.3, 5.0 and 4.2, respectively. Analytical investigations on the precipitates formed confirm the results of the electrometric study.
20
Accornero, Guya. "João Madeira, Irene Flunser Pimentel & Luís Farinha, Vítimas de Salazar. Estado Novo e violência política, prefácio de Fernando Rosas, Lisboa, Esfera dos Livros, 2007, 452 p., ISBN : 978-989-626-044-6." Lusotopie 16, no. 1 (October 23, 2009): 220–24. http://dx.doi.org/10.1163/17683084-01601023.
21
Salami, Simpa Samuel, Oksana Yaskiv, Baris Turkbey, Robert Villani, Eran Ben-Levi, and Ardeshir Rastinehad. "Correlation of apparent diffusion coefficients (ADCs) on diffusion-weighted (DW) magnetic resonance (MR) imaging with lesion size and prostate cancer risk." Journal of Clinical Oncology 33, no. 7_suppl (March 1, 2015): 48. http://dx.doi.org/10.1200/jco.2015.33.7_suppl.48.
Анотація:
48 Background: A negative correlation between ADC values and Gleason risk of prostate cancer (CaP) has been reported by the NIH. We correlate ADC values on DW MR imaging with lesion size and risk stratification of CaP. Methods: Men with abnormal DRE or PSA underwent a 3T MP-MRI (T2, DWI, and DCE) with an endorectal coil. ADC maps were calculated using b values of 0, 500, 1,000 and 1,500; additional b 2000 images were obtained separately. Three radiologists (EB, RV, AR) reviewed and graded all lesions using the 5-point Likert scale and PI-RADS score. A total of 268 men with suspicious lesion (s) on MRI were prospectively enrolled. The UroNav system (Invivo, Florida) was used to perform MR/TRUS fusion-guided prostate biopsies, obtaining one biopsy core in axial and sagittal planes from each lesion. Our institution’s pathologist reviewed all biopsies. Lowest ADC values of suspicious lesions were correlated against lesion size and Gleason risk stratification. Results: The median age and PSA were 65.0 years and 7.4 ng/mL respectively. An average of 1.5 (378/256) suspicious lesions per patient was identified on the MP-MRI. Median volume of MRI target lesions was 0.36 cm3. The cancer detection rate of fusion biopsy on lesion level analysis was 45.2 % (171/378). The mean ± SD ADC values (x 10-6 mm2/sec) for lesions negative and positive for CaP were 1022 ± 260 and 724 ± 223 respectively (p <0.0001). The mean ± SD ADC values (x 10-6 mm2/sec) for lesion size < 0.2 cm3, 0.2 – 0.5 cm3, 0.5 – 1.0 cm3, and > 1 cm3 were 771 ± 246, 677 ± 206, 629 ± 119, and 500 ± 86respectively. Higher risk CaP was associated with lower ADC values with AUC of 0.77 (p=0.0001). The mean ± SD ADC values (x 10-6 mm2/sec) for low (≤6), intermediate (7), and high (8-10) Gleason grade CaP were 845 ± 285, 687± 195, and 628 ± 145 respectively. Conclusions: The ADC value of suspicious lesions on MRI has an inverse correlation with lesion size and prostate cancer risk. It may be a useful in predicting CaP and its clinical significance. Further studies are needed to determine its value in stratifying patients for prostate biopsy, active surveillance and/or treatment.
22
Ramsey, S. D., S. D. Sullivan, J. Malin, D. K. Blough, L. Clarke, and J. S. McCune. "Colony stimulating factor use and outcomes for breast, lung, and colorectal cancer patients in Washington State." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 6616. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.6616.
Анотація:
6616 Background: Guidelines recommend colony stimulating factor (CSF) primary prophylaxis (PP) with chemotherapy if febrile neutropenia risk (FN) is =20%. Use of and outcomes for persons receiving CSF in clinical practice are relatively unknown. Methods: Using claims for Medicare and Medicaid enrollees linked to the Puget Sound SEER registry, breast (BCa), lung (LCa) and colorectal cancer (CRCa) patients diagnosed 2002–04 who received chemotherapy were categorized as: CSF at the start of chemotherapy (PP); other CSF; no CSF. Logistic regression was used to determine predictors of CSF PP and hospitalization for FN, controlling for cancer stage, age, sex, race, chemotherapy FN risk (from the National Comprehensive Cancer Network), radiation therapy, CSF use, health insurance, surgery =30 days of chemotherapy. Results: 364 BCa, 908 LCa, and 452 CRCa patients received chemotherapy. 43% of BCa, 30% of LCa, and 15% of CRCa patients received CSF. Only 9%, 6%, and 0.6% of patients initiated CSF as PP in the first cycle of chemotherapy. CSF use increased for all cancers, but most for BCa, (36% in 2002 to 70% in 2004); PP increased from 5% to 26%. Significant predictors (p<0.05) of PP were: BCa–local vs distant stage (OR 0.2), regional vs distant (OR 0.6), chemotherapy FN risk high vs low (OR 6.7); LCa–chemotherapy FN risk high vs low (OR 8.9), intermediate vs low (OR 6.3). FN incidence was 11%, 18% and 32% for BCa, CRCa, LCa, respectively. Significant predictors of FN were: BCa–nonwhite race (OR 2.7); LCa–surgery within 30 days (OR 1.7); CRCa–regional vs. distant (OR 0.4) and chemotherapy FN risk intermediate vs. low (OR 4.2). Conclusions: CSF use has increased significantly, but often in settings where efficacy is uncertain. Cancer type, stage and chemotherapy risk of FN influenced use of primary prophylaxis. Non-chemotherapy factors also appear to influence risk for FN. No significant financial relationships to disclose.
23
Terragni, Pier Paolo, Lorenzo Del Sorbo, Luciana Mascia, Rosario Urbino, Erica L. Martin, Alberto Birocco, Chiara Faggiano, Michael Quintel, Luciano Gattinoni, and V. Marco Ranieri. "Tidal Volume Lower than 6 ml/kg Enhances Lung Protection." Anesthesiology 111, no. 4 (October 1, 2009): 826–35. http://dx.doi.org/10.1097/aln.0b013e3181b764d2.
Анотація:
Background Tidal hyperinflation may occur in patients with acute respiratory distress syndrome who are ventilated with a tidal volume (VT) of 6 ml/kg of predicted body weight develop a plateau pressure (PPLAT) of 28 < or = PPLAT < or = 30 cm H2O. The authors verified whether VT lower than 6 ml/kg may enhance lung protection and that consequent respiratory acidosis may be managed by extracorporeal carbon dioxide removal. Methods PPLAT, lung morphology computed tomography, and pulmonary inflammatory cytokines (bronchoalveolar lavage) were assessed in 32 patients ventilated with a VT of 6 ml/kg. Data are provided as mean +/- SD or median and interquartile (25th and 75th percentile) range. In patients with 28 < or = PPLAT < or = 30 cm H2O (n = 10), VT was reduced from 6.3 +/- 0.2 to 4.2 +/- 0.3 ml/kg, and PPLAT decreased from 29.1 +/- 1.2 to 25.0 +/- 1.2 cm H2O (P < 0.001); consequent respiratory acidosis (Paco2 from 48.4 +/- 8.7 to 73.6 +/- 11.1 mmHg and pH from 7.36 +/- 0.03 to 7.20 +/- 0.02; P < 0.001) was managed by extracorporeal carbon dioxide removal. Lung function, morphology, and pulmonary inflammatory cytokines were also assessed after 72 h. Results Extracorporeal assist normalized Paco2 (50.4 +/- 8.2 mmHg) and pH (7.32 +/- 0.03) and allowed use of VT lower than 6 ml/kg for 144 (84-168) h. The improvement of morphological markers of lung protection and the reduction of pulmonary cytokines concentration (P < 0.01) were observed after 72 h of ventilation with VT lower than 6 ml/kg. No patient-related complications were observed. Conclusions VT lower than 6 ml/Kg enhanced lung protection. Respiratory acidosis consequent to low VT ventilation was safely and efficiently managed by extracorporeal carbon dioxide removal.
24
Nguyen, Van Thang, та Tri Hieu Pham. "Nhận xét kết quả của kỹ thuật LEEP điều trị tổn thương cổ tử cung tại Bệnh viện Phụ sản Trung Ương". Tạp chí Phụ sản 16, № 4 (1 червня 2019): 143–47. http://dx.doi.org/10.46755/vjog.2019.4.584.
Анотація:
Kỹ thuật điều trị LEEP cổ tử cung là phương pháp cắt bỏ các tổn thương tiền ung thư tại cổ tử cung bằng vòng điện.
Mục tiêu: Nhận xét các đặc điểm của đối tượng nghiên cứu; hiệu quả và tính an toàn của kỹ thuật LEEP tại Bệnh viện Phụ sản Trung ương.
Phương pháp nghiên cứu: Mô tả, theo dõi dọc trên 95 bệnh nhân từ tháng 6/2018 đến tháng 3/2019.
Kết quả: Tỷ lệ nhiễm HPV type nguy cơ cao là 76,8%, tỷ lệ xét nghiệm tế bào âm đạo bất thường là: LSIL: 31,7%, HSIL: 14,7%, ASCUS – H 6,3%, các bất thường biểu mô tuyến 5,3%. Giải phẫu bệnh sau LEEP: CIN I: 21,1%, CIN II: 14,7%, CIN III: 8,4%, CIS: 4,2%, ung thư biểu mô vảy xâm lấn: 1,1%. Có 13/95 bệnh nhân sau LEEP được chỉ định mổ cắt tử cung vì các tổn thương từ CIN III trở lên. Tỷ lệ đốt điện, chèn mèche trong thủ thuật tương ứng 91,6% và 94,7%. Tỷ lệ chảy máu trong vòng 6 tiếng sau LEEP là 6,3%, trong vòng 1 tháng là 2,4%, không có trường hợp nào nhiễm trùng. Theo dõi sau 6 tháng chưa phát hiện trường hợp nào tái phát.
Kết luận: LEEP là phương pháp điều trị hiệu quả, an toàn và thuận tiện,
25
Osterborg, Anders, Andrzej Hellmann, and Stephen Couban. "CERA (Continuous Erythropoietin Receptor Activator): Dose-Response Trial of Subcutaneous (SC) Administration Once Every 3 Weeks (Q3W) to Patients with Aggressive Non-Hodgkin’s Lymphoma and Anemia Receiving Chemotherapy." Blood 104, no. 11 (November 16, 2004): 4225. http://dx.doi.org/10.1182/blood.v104.11.4225.4225.
Анотація:
Abstract CERA is an erythropoiesis-stimulating agent (ESA) acting differently at the receptor level with a prolonged half-life. In this ongoing, multicenter, randomized, open-label, Phase II dose-response study, CERA was administered subcutaneously in a Q3W schedule to 93 transfusion-independent patients with aggressive (intermediate or high grade) B-cell non-Hodgkin’s lymphoma (NHL) and anemia receiving combination chemotherapy. Eligible patients met the following inclusion criteria: age ≥18 years, hemoglobin (Hb) <11 g/dL, combination chemotherapy scheduled to be administered throughout the 12-week treatment period, life expectancy >6 months, and Eastern Cooperative Oncology Group (ECOG) performance status grade 0–2. Major exclusion criteria included transferrin saturation <20% and platelet count <50 x 109/L. No patient had received an ESA in the 8 weeks prior to the first dose of CERA. Patients were randomized to receive CERA 2.1 μg/kg (n=31), 4.2 μg/kg (n=30), or 6.3 μg/kg (n=32) administered once every 3 weeks for 12 weeks. The primary efficacy variable was time-adjusted average change in Hb from baseline during 12 weeks, until end of initial treatment (last observed value before dose change or transfusion). Enrollment has been completed; the treatment phase of the trial is nearing conclusion. Demographics show similar baseline characteristics in all three patient subgroups [mean age: 62.9 years (2.1 μg/kg); 59.1 years (4.2 μg/kg); 64.3 years (6.3 μg/kg)]. Diffuse large B-cell lymphoma was the most common lymphoma in all three subgroups (87%, 70%, and 84% of patients in the 2.1, 4.2, and 6.3 μg/kg subgroups, respectively). To date, the majority of patients receive an anthracycline-containing chemotherapy regimen, either standard CHOP or CHOP plus rituximab. Preliminary efficacy and safety results will be presented. Ongoing assessments have indicated a safety profile consistent with that seen in patients with aggressive NHL and anemia receiving chemotherapy. This Phase II trial will help further characterize the ability of CERA to safely correct anemia when administered at an extended dosing interval (Q3W) to patients with aggressive NHL receiving chemotherapy.
26
Mia, Md Zakaria, and Mohammad Ariful Islam. "Streptococcus pneumoniae, a pathogen of childhood pneumonia: an evaluation of isolated serotypes for vaccine effectiveness." Asian Journal of Medical and Biological Research 6, no. 4 (January 7, 2021): 618–22. http://dx.doi.org/10.3329/ajmbr.v6i4.51226.
Анотація:
The burden of serious pneumococcal disease is the heaviest in the developing world that focuses on its diagnostic importance. The incidence of pneumonoccoal disease in different regions of the world is not caused by some specific serotypes or serogroups of pneumonocci rather they are randomly distributed in population. A total number of 412 nasopharyngeal swab samples were cultures between January 2010 and December 2012. All the isolates were serotyped by using chessboard modification of quellung methods. A total of 102 S. pneumoniae isolates were found. The distribution among age groups shows that age groups 15 years and over 60 years are more frequent. The most common serotypes were 20 (17.6%), 33(16.7%), 6 (15.7%), 19 (14.7%) and 23 (10.8%) types. The addition of a pneumococcal vaccine (PCV) covering the prevalent serotypes in the immunization program could be useful for reducing the burden of pneumococcal diseases.
Asian J. Med. Biol. Res. December 2020, 6(4): 618-622
27
Akagami, Masataka, Shoko Oya, Yuki Kashima, Satoko Seki, Yoshinao Ouchi, and Yoko Hayama. "A hematologic key for bovine leukemia virus screening in Japanese black cattle." Journal of Veterinary Diagnostic Investigation 31, no. 4 (May 3, 2019): 568–71. http://dx.doi.org/10.1177/1040638719848449.
Анотація:
The European Community’s leukosis key (EC key) is a well-known hematologic method for detecting bovine leukemia virus (BLV) infection in dairy cattle. The key identifies infected cattle with persistent lymphocytosis via a combination of lymphocyte count (LC) and age. Using the EC key to identify BLV-infected Japanese black (JB) cattle is problematic, however, given the inherently lower LCs of JB cattle compared to dairy cattle. We analyzed the LC in BLV-positive and -negative JB cattle and estimated LC cutoff values by age using receiver operating characteristic curve analysis. Among the 716 JB blood samples collected, 452 (63%) JB cattle were confirmed as BLV-positive by an antibody ELISA for ≥1-y-old cattle and by real-time PCR for <1-y-old cattle. The cutoff values for the LC in each age group were calculated as 6.3 × 109/L for <1 y, 5.9 × 109/L for 1 to <2 y, 5.5 × 109/L for 2 to <3 y, 4.5 × 109/L for 3 to <6 y, 4.3 × 109/L for 6 to ≤10 y, and 3.7 × 109/L for >10 y. The sensitivity and specificity of the estimated cutoff values were 0.49 (95% confidence interval: 0.44–0.53) and 0.81 (0.75–0.85), whereas those of the EC key were 0.20 (0.16–0.24) and 0.99 (0.97–1.00). Our LC cutoff values for screening JB cattle for BLV infection appear to be preferable to those of the EC key.
28
Miguel Miguel, Hugo, and Jesús Hurtado Rivera. "Análisis de la sección de discusión de los artículos científicos de los docentes investigadores de la UNCP, 2008-2012." Prospectiva Universitaria 11, no. 1 (August 8, 2020): 19–25. http://dx.doi.org/10.26490/uncp.prospectivauniversitaria.2014.11.3.
Анотація:
Se analizó la discusión de los artículos científicos elaborados por los docentes investigadores de la UNCP, entre los años 2008 al 2012. La población del estudio estuvo constituida por todos los artículos científicos producidos anualmente por los docentes investigadores. La muestra de estuvo compuesta por 48 artículos, obtenidos probabilísticamente; para N = 2118; Zα2 = 1,962; para una seguridad del 95 %; p = proporción esperada (5 % = 0.05); q = 1- p (1-0.05 = 0.95); d = Precisión (10 %). En cada facultad se eligieron al azar 6 artículos científicos. Los datos del estudio provienen de la base de datos de los investigadores del Centro de Investigación de la UNCP. Con los hallazgos conseguidos se concluye que; los porcentajes de los niveles de la interpretación de los datos son: 39.6 % de nivel mediano; 52.1 % de nivel bajo; y 8.3 % de nivel nulo; los porcentajes de los niveles de implicaciones de los datos son: 6.3 % de nivel bajo; y 93.8 % de nivel nulo; los porcentajes de los niveles de definición de las potenciales limitaciones del estudio son: 6.3 % del nivel mediano; el 4.2 % del nivel bajo; y 89.6 % de nivel nulo; los porcentajes de los niveles de concordancias discordancias con publicaciones anteriores son: 12.5 % de nivel mediano; 20.8 % de nivel bajo; y 66.7 % de nivel nulo; y los porcentajes de los niveles de las aplicaciones prácticas de los resultados son: 6.3 % % de nivel bajo; 93.8 % de nivel nulo.
29
Tütken, Gisela. "Anschütz, Martina; Wrobel , Jürgen: Deutsch lesen und schreiben: Ein Lehrbuch für Jugendliche und Erwachsene zur Förderung der schriftsprachlichen Grundfertigkeiten. Frankfurt am Main : Diesterweg, 1986 - ISBN 3-425- 07902-6. 134 Seiten, DM 19,80." Informationen Deutsch als Fremdsprache 14, no. 5-6 (December 1, 1987): 409–12. http://dx.doi.org/10.1515/infodaf-1987-145-603.
30
Bowman, J. Patrick, Michael P. Nedley, Kimberly A. Jenkins, and Charles R. Fahncke. "Pilot Study Comparing Nasal vs Oral Intubation for Dental Surgery by Physicians, Nurse Anesthetists, and Trainees." Anesthesia Progress 65, no. 2 (June 1, 2018): 89–93. http://dx.doi.org/10.2344/anpr-65-02-07.
Анотація:
The purpose of this article was to determine if pediatric dental treatment under general anesthesia utilizing orotracheal intubation takes longer than using nasotracheal intubation techniques. Twenty-six American Society of Anesthesiologists Physical Status Classification I and II pediatric dental patients, ages 2–8 years treated under general anesthesia, were assigned to 1 of 2 groups: (a) nasotracheal intubation (control, n = 13), (b) orotracheal intubation (experimental, n = 13). Times for intubation, radiographic imaging, and dental procedures, as well as total case time were quantified. Data were collected on airway difficulty, numbers of providers needed for intubation, intubation attempts, and intubation trauma. There was a significant difference in mean intubation time (oral = 2.1 minutes versus nasal = 6.3 minutes; p < .01). There was no difference in mean radiograph time (oral = 4.2 minutes versus nasal = 3.4 minutes; p = .144), and overall radiograph image quality was not affected. There was no difference in dental procedure time (p = .603) or total case time (p = .695). Additional providers were needed for intubation and more attempts were required for nasotracheal intubation versus orotracheal intubation (6 additional providers/22 attempts vs 0 additional providers/15 attempts, p < .01 and p < .05, respectively). Nine of 13 nasotracheal intubations were rated as traumatic (69%) versus 0 of 13 for orotracheal intubations (0%) (p < .01). In 7/9 orotracheal intubation cases (78%), the tube was not moved during treatment (p < .01). Orotracheal intubation does not increase case time, does not interfere with radiographic imaging, and is less traumatic for the patient when performed by physician anesthesiologists, emergency and pediatric medicine physician residents, certified registered nurse anesthetists, and student nurse anesthetists, all with variable nasotracheal intubation experience.
31
Byrne, Declan, Joseph G Browne, Richard Conway, Seán Cournane, Deirdre O’Riordan, and Bernard Silke. "Mortality outcomes and emergency department wait times – the paradox in the capacity limited system." Acute Medicine Journal 17, no. 3 (July 1, 2018): 130–36. http://dx.doi.org/10.52964/amja.0717.
Анотація:
Background: There is concern that undue ED wait times may result in adverse outcomes. Methods: We studied 30-day in-hospital mortality (2002-2017) for all medical admissions (106,586 episodes; 54,928 patients) focusing on clinical risk profile Results: Comparing 2002-09 vs. 2010-17, median ED waits > 6 hours (hr) increased 10h (95% CI: 8,13) to 15h (95% CI: 9,19). 30-day mortality declined 6.2% to 4.9%- (RRR- 20.8%/ NNT- 78). 30-day-mortality by ED wait: – < 4hr 6.6% (95% CI: 6.3%, 6.9%), 4-8hr 4.8% (95% CI: 4.6%, 5.0%), 8-12hr 4.3% (95% CI: 4.1%, 4.5%) or >=12hr 4.2% (95% CI: 3.9%, 4.5%). Conclusion: Admissions with shorter waits are overrepresented with high clinical acuity. Higher Risk Score patient with extended wait times had worse clinical outcomes.
32
Lojkić, Ivana, Marina Biđin, Zdenko Biđin, and Milivoj Mikec. "Viral Agents Associated with Poult Enteritis in Croatian Commercial Turkey Flocks." Acta Veterinaria Brno 79, no. 1 (2010): 91–98. http://dx.doi.org/10.2754/avb201079010091.
Анотація:
From 2003 to 2006, samples of intestinal content and spleens from 10-day-old to 6-week-old fattening turkeys showing clinical signs of enteritis were analyzed by specific PCR and RT-PCRs for detection of haemorrhagic enteritis virus (HEV), avian reovirus (ARV), turkey astrovirus-2 (TastV-2), and turkey coronavirus (TCV). A total of 23 flocks from 6 farms were included in the study. Specific sequence for HEV hexon gene was present in 6 samples from turkeys younger than and in one turkey at 6 weeks of age. A product of TastV-2 capsid gene was detected in 17/23 intestinal content samples. A 626-bp band of sigma A (S2) encoding gene segment from avian reovirus was present in three samples, all from the same farm. Sequence analysis of 450 bp fragment of avian reovirus sigma A encoding gene sequence showed that our strain had the identity of 91.3% with the strains 138, 2408, 1733, 919, T6, and Os161. No TCV specific PCR band was found in any sample. Four flocks were positive simultaneously for HEV and TastV-2, and three flocks on TastV-2 and ARV. Severity of poult enteritis described in our study is caused by immunosuppressive TastV-2 in combination with HEV or ARV.
33
Krausz, Alyse D., Frederick K. Korley, and Mark A. Burns. "A Variable Height Microfluidic Device for Multiplexed Immunoassay Analysis of Traumatic Brain Injury Biomarkers." Biosensors 11, no. 9 (September 7, 2021): 320. http://dx.doi.org/10.3390/bios11090320.
Анотація:
Traumatic brain injury (TBI) is a leading cause of global morbidity and mortality, partially due to the lack of sensitive diagnostic methods and efficacious therapies. Panels of protein biomarkers have been proposed as a way of diagnosing and monitoring TBI. To measure multiple TBI biomarkers simultaneously, we present a variable height microfluidic device consisting of a single channel that varies in height between the inlet and outlet and can passively multiplex bead-based immunoassays by trapping assay beads at the point where their diameter matches the channel height. We developed bead-based quantum dot-linked immunosorbent assays (QLISAs) for interleukin-6 (IL-6), glial fibrillary acidic protein (GFAP), and interleukin-8 (IL-8) using DynabeadsTM M-450, M-270, and MyOneTM, respectively. The IL-6 and GFAP QLISAs were successfully multiplexed using a variable height channel that ranged in height from ~7.6 µm at the inlet to ~2.1 µm at the outlet. The IL-6, GFAP, and IL-8 QLISAs were also multiplexed using a channel that ranged in height from ~6.3 µm at the inlet to ~0.9 µm at the outlet. Our system can keep pace with TBI biomarker discovery and validation, as additional protein biomarkers can be multiplexed simply by adding in antibody-conjugated beads of different diameters.
34
Haryeni Tamin. "Persepsi Mahasiswa Sastra terhadap Pembelajaran Daring melalui Aplikasi Zoom." Jurnal Onoma: Pendidikan, Bahasa, dan Sastra 7, no. 1 (May 20, 2021): 132–43. http://dx.doi.org/10.30605/onoma.v7i1.610.
Анотація:
Penelitian ini bertujuan untuk mengetahui persepsi mahasiswa terhadap pembelajaran daring pada mata kuliah Sosiologi Sastra di Departemen Sastra Indonesia Fakultas Ilmu Budaya Universitas Hasanuddin selama masa pandemi virus corona (COVID-19) melalui aplikasi Zoom. Persepsi mahasiswa terhadap pembelajaran daring dibatasi pada aspek belajar mengajar, kapabilitas (kemampuan dosen), serta sarana dan prasarana. Penelitian ini merupakan penelitian deskriptif kuantitatif. Populasi pada penelitian ini adalah seluruh mahasiswa sastra di Departemen Sastra Indonesia Fakultas Ilmu Budaya Universitas Hasanuddin. Sampel sebanyak 48 orang diambil dengan menggunakan teknik purposive sampling yang hanya berfokus pada mahasiswa yang sedang mengambil mata kuliah Sosiologi Sastra sejak diberlakukan pembelajaran daring karena pandemi COVID-19. Data dikumpulkan dengan menggunakan kuesioner secara daring melalui aplikasi google form dan wawancara mendalam kepada beberapa mahasiswa untuk mendapatkan informasi yang lebih mendetail. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis statistik dan deskriptif yang terdiri atas pengumpulan data, reduksi data, penyajian data, dan penarikan simpulan. Hasil penelitian ini menunjukkan bahwa persepsi mahasiswa terhadap pembelajaran daring melalui aplikasi Zoom pada mata kuliah Sosiologi Sastra bersifat positif, dengan rincian: data pada indikator 1, yakni: 14,6% (SS), 62,5% (S), 20,8% (TS), dan 4,2% (STS). Data indikator 2, yakni: 4,2% (SS), 60,4% (S), 35,4% (TS), dan 0% (STS). Data indikator 3, yakni: 22,9% (SS), 68,8% (S), 8,3% (TS), dan 0% (STS). Data indikator 4, yakni: 0% (SS), 47,9% (S), 52,1% (TS), dan 4,2% (STS). Data indikator 5, yakni: 47,9% (SS), 52,1% (S), 2,1% (TS), dan 0% (STS). Data indikator 6, yakni: 47,9% (SS), 52,1% (S), 2,1% (TS), dan 0% (STS). Data indikator 6, yakni: 47,9% (SS), 52,1% (S), 2,1% (TS), dan 0% (STS). Data indikator 7, yakni: 35,4% (SS), 64,6% (S), 0% (TS) dan (STS). Data indikator 8, yakni: 29,2% (SS), 66,7% (S), 10,4% (TS), 2,1% (STS). Data indikator 9, yakni: 29,2% (SS), 68,8% (S), 6,3% (TS), 0% (STS). Adapun data indikator 10, yakni: 4,2% (SS), 54,2% (S), 43,8% (TS), 10,4% (STS).
35
Saraf, Vinay, Satyaprakash Mahajan, Gaurav Deshmukh, Dhiraj Dhoot, and Hanmant Barkate. "Effectiveness and safety of ciclopirox olamine in patients with dermatophytosis: a retrospective cohort analysis." International Journal of Research in Dermatology 7, no. 1 (December 24, 2020): 38. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20205592.
Анотація:
<p class="abstract"><strong>Background:</strong> The current scenario of dermatophytosis is alarming, despite the availability of multiple antifungal agents the management of dermatophytosis is still challenging. Hence there is a need for a different antifungal with a novel mechanism of action for the management of dermatophytosis.</p><p class="abstract"><strong>Methods: </strong>It was retrospective cohort study where in record of patients with dermatophytosis who were candidates for topical therapy only were analysed. All the patients were treated with Ciclopirox olamine 1% twice daily for 6 weeks. The efficacy end points were complete cure rate, mycological cure rate and clinical cure rate.</p><p class="abstract"><strong>Results: </strong>613 patients were included in the final analysis. At the end of study period the complete, mycological and clinical cure rates were 73.89%, 75.37% and 77.65% respectively. Out of 613 patients included 528 patients showed treatment failure to previous topical antifungal agents while 84 patients were treatment naïve. In treatment failure patients the complete, mycological and clinical cure rates were 72.15%, 73.48, and 75.56% respectively. In treatment naïve patients the complete, mycological and clinical cure rates were 84.70%, 87.05% and 90.58% respectively. 5.70% reported adverse events. The most common adverse event was pruritus followed erythema, dryness and rash.</p><p><strong>Conclusions: </strong>Results of this study proves that ciclopirox is efficacious and safe in the management of dermatophytosis. This study also proves that ciclopirox is useful in those patients who failed to respond to other topical antifungal agents. </p>
36
Halbert, James D., Debra R. Van Tuyll, Carl Purdy, Guang Hao, Steven Cauthron, Christine Crookall, Baban Babak, Richard Topolski, Ayman Al-Hendy, and Gaston K. Kapuku. "Low Frequency Music Slows Heart Rate and Decreases Sympathetic Activity." Music and Medicine 10, no. 4 (October 28, 2018): 180. http://dx.doi.org/10.47513/mmd.v10i4.614.
Анотація:
Objectives: Increasing blood pressure (BP) increases the risk of developing cardiovascular disease (CVD). Lower frequency music may lower BP and heart rate (HR), therefore, decreases the CVD risk. Methods: Participants were 16 high BP individuals aged 20 to 50 years. The protocol consisted of 2 visits (experimental & control). Music was tuned between 440 Hz and 432 Hz, and the frequencies changed every 10 minutes. HR variability, diastolic function, oxytocin, and amylase were recorded at each phase. An (ANOVA) was used to examine the effects of music. Results: Mental arithmetic significantly increased BP and HR (all ps<0.01). There were significant differences between the stress condition and all other conditions, all p’s < .02. There was a significant main effect for Music Order, F (1, 6) = 6.23, p = .047, ƞp2= .51, β = .55. Participants had lower HR listening to 432 Hz music (M = -7.20, se = 2.47) than 440 Hz music (M = -5.33, se = 2.71), t(7) = 2.53, p = .04, d ‘ = .41. Conclusion: Listening to low frequency music has cardiovascular benefits including slowing heart rate and promoting relaxation. Further study is needed to determine the underlying mechanisms of music induced beneficial effects.
37
Chávez Torres, Martha. "Herrejón Peredo, C. (coord.; 2011), La formación geográfica de México, Consejo Nacional para la Cultura y las Artes, México, vol. I, 312 p., ISBN 978-607-455-621-6." Investigaciones Geográficas, no. 77 (April 9, 2012): 145. http://dx.doi.org/10.14350/rig.31029.
38
Wedding, Ulrich, Friedemann Honecker, Klaus Rettig, Susanne Huschens, and Carsten Bokemeyer. "Comprehensive Geriatric Assessment (CGA) in Elderly Patients with Hematological Neoplasia: CGA and Not Age Predicts Mortality - Results from in-GHO®-Registry." Blood 112, no. 11 (November 16, 2008): 1310. http://dx.doi.org/10.1182/blood.v112.11.1310.1310.
Анотація:
Abstract Background: The internet based registry of IN-GHOα prospectively collects data of elderly cancer patients (pts) 370 yrs. We report data from 450 pts with hematological neoplasia (HE) out of 1580 cancer patients registered currently. To gain more insight into feasibility of treatment in elderly patients, results of a comprehensive geriatric assessment (CGA), physicians’ and pts’ judgement of fitness, and outcome measures were studied. Methods: Besides demographic data, activities of daily living (ADL), instrumental activities of daily living (IADL), Karnofsky-Performance-Statuts (KPS), co-morbidity (Charlson score), medication (number of drugs not related the HE treatment), mobility (Timed-Up&Go-Test), cognition (MMSE), and depression (SCID screening) results were collected. Age, results of CGA, physicians’ rating (fit vs. compromised vs. frail) and pts’ self rated fitness (lickert scale for 1= very fit to 6 very unfit) for treatment were analysed for their association with death. Follow up assessment was scheduled 8–12 weeks and 5–7 months after inclusion. Results: 450 patients, mean age 77.7 years (SD 5.7; range 69–97), 43.3%male, were included. Main diagnoses were aggressive lymphoma n = 135 (30%), chronic lymphocytic leukemia n = 66 (14.7), multiple myeloma n = 54, acute myeloid leukemia n = 27 (6.0%), and others. Physicians rating of patientś fitness for treatment: fit 54.4%, compromised 39.1%, frail 5.5%. Patients rating of patientś fitness for treatment: 1 = 19.6%, 2 = 31.8%, 3 = 25.1%, 4 = 13.6%, 5 = 3.8%, 6 = 1.1%. During follow up (median 178 days), 98 pts (21.8%) patients died: mean age (77.5 vs. 78.5; p=0.219), mean BMI (25.6 vs. 25.3; p=0.228), mean Charlson-score (2.0 vs. 2.3; p=0.28) and mean number of drugs (4.0 vs. 4.2; p=0.14) were not associated with death. However significantly associated with death during follow up were mean ADL score (94.0 vs. 87.4; p=0.047), mean IADL score (7.1 vs. 6.3; p<0.001), mean KPS score (83 vs. 74; p=0.001), mean MMSE score (26 vs. 24; p=0.03), categorical Timed-Up&Go-Test (< 10 sec 18% vs. > 20 sec 38%; p<0.001), categorical SCID screening (no depression 18% vs. depression 31%; p<0.001), physicianś rating of fitness (fit 18.8%, compromised 21.6%, frail 52.0%; p=0.001) and patientś rating of fitness (lickert scale 2.3 vs. 3.4; p<0.001). Conclusion: Patients characteristics as assessed by CGA and not age are associated with death in elderly patients with hematological malignancies. Results of CGA should be validated in treatment algorithm for this population.
39
Miguel Miguel, Hugo, and Jesús Hurtado Porras. "Análisis de la sección de discusión de los artículos científicos de los docentes investigadores de la UNCP, 2008-2012." Prospectiva Universitaria 11, no. 1 (June 4, 2017): 19. http://dx.doi.org/10.26490/uncp.1990-7044.2014.1.271.
Анотація:
<p>Se analizó la discusión de los artículos científicos elaborados por los docentes investigadores de la UNCP, entre los años 2008 al 2012. La población del estudio estuvo constituida por todos los artículos científicos producidos anualmente por los docentes investigadores. La muestra de estuvo compuesta por 48 artículos, obtenidos probabilísticamente; para N = 2118; Zα 2 =1,962; para una seguridad del 95 %; p = proporción esperada (5 % = 0.05); q = 1- p (1-0.05 = 0.95); d = Precisión (10 %). En cada facultad se eligieron al azar 6 artículos científicos. Los datos del estudio provienen de la base de datos de los investigadores del Centro de Investigación de la UNCP. Con los hallazgos conseguidos se concluye que; los porcentajes de los niveles de la interpretación de los datos son: 39.6 % de nivel mediano; 52.1 % de nivel bajo; y 8.3 % de nivel nulo; los porcentajes de los niveles de implicaciones de los datos son: 6.3 % de nivel bajo; y 93.8 % de nivel nulo; los porcentajes de los niveles de definición de las potenciales limitaciones del estudio son: 6.3 % del nivel mediano; el 4.2 % del nivel bajo; y 89.6 % de nivel nulo; los porcentajes de los niveles de concordancias o discordancias con publicaciones anteriores son: 12.5 % de nivel mediano; 20.8 % de nivel bajo; y 66.7 % de nivel nulo; y los porcentajes de los niveles de las aplicaciones prácticas de los resultados son: 6.3 % % de nivel bajo; 93.8 % de nivel nulo.</p><p> </p>
40
Jalali, Niloofar, Kirti Sundar Sahu, Arlene Oetomo, and Plinio Pelegrini Morita. "Usability of Smart Home Thermostat to Evaluate the Impact of Weekdays and Seasons on Sleep Patterns and Indoor Stay: Observational Study." JMIR mHealth and uHealth 10, no. 4 (April 1, 2022): e28811. http://dx.doi.org/10.2196/28811.
Анотація:
Background Sleep behavior and time spent at home are important determinants of human health. Research on sleep patterns has traditionally relied on self-reported data. Not only does this methodology suffer from bias but the population-level data collection is also time-consuming. Advances in smart home technology and the Internet of Things have the potential to overcome these challenges in behavioral monitoring. Objective The objective of this study is to demonstrate the use of smart home thermostat data to evaluate household sleep patterns and the time spent at home and how these behaviors are influenced by different weekdays and seasonal variations. Methods From the 2018 ecobee Donate your Data data set, 481 North American households were selected based on having at least 300 days of data available, equipped with ≥6 sensors, and having a maximum of 4 occupants. Daily sleep cycles were identified based on sensor activation and used to quantify sleep time, wake-up time, sleep duration, and time spent at home. Each household’s record was divided into different subsets based on seasonal, weekday, and seasonal weekday scales. Results Our results demonstrate that sleep parameters (sleep time, wake-up time, and sleep duration) were significantly influenced by the weekdays. The sleep time on Fridays and Saturdays is greater than that on Mondays, Wednesdays, and Thursdays (n=450; P<.001; odds ratio [OR] 1.8, 95% CI 1.5-3). There is significant sleep duration difference between Fridays and Saturdays and the rest of the week (n=450; P<.001; OR 1.8, 95% CI 1.4-2). Consequently, the wake-up time is significantly changing between weekends and weekdays (n=450; P<.001; OR 5.6, 95% CI 4.3-6.3). The results also indicate that households spent more time at home on Sundays than on the other weekdays (n=445; P<.001; OR 2.06, 95% CI 1.64-2.5). Although no significant association is found between sleep parameters and seasonal variation, the time spent at home in the winter is significantly greater than that in summer (n=455; P<.001; OR 1.6, 95% CI 1.3-2.3). These results are in accordance with existing literature. Conclusions This is the first study to use smart home thermostat data to monitor sleep parameters and time spent at home and their dependence on weekday, seasonal, and seasonal weekday variations at the population level. These results provide evidence of the potential of using Internet of Things data to help public health officials understand variations in sleep indicators caused by global events (eg, pandemics and climate change).
41
Maldonado, Jose Alberto, Minsoo Kim, Prasamsa Pandey, Sarah Todd, Kaitlin Marie Christopherson, Matthew S. Ning, David R. Grosshans, et al. "Use of a rapid access multidisciplinary bone metastases clinic to decrease financial toxicity for patients undergoing single-fraction palliative radiation." Journal of Clinical Oncology 38, no. 29_suppl (October 10, 2020): 24. http://dx.doi.org/10.1200/jco.2020.38.29_suppl.24.
Анотація:
24 Background: A rapid access bone metastases clinic (RABC) was instituted at MD Anderson Cancer Center (MDACC) to allow outpatient consult, simulation and radiation treatment (RT) initiation in < 6 hours for patients with painful bone metastases. Patients underwent multidisciplinary evaluation with orthopedics and radiation oncology. One aspect of financial toxicity is distress due to out-of-pocket (OOP) cost associated with a treatment. We hypothesized the RABC would decrease financial toxicity for MDACC patients over traditional RT. Methods: RABC patients surveyed between April 2018 and January 2020 were included. Patients were asked to estimate OOP cost for RT (including travel and treatment cost) and perceived cost burden of treatment. Travel distance was hometown distance to MDACC. Subset analyses were performed for patients receiving single fraction (1fx) and 2-5 fractions (2-5fx). Estimated OOP cost (1fx: RABCN= 34, nonRABCN= 20; 2-5fx: RABCN= 4, nonRABCN= 22), perceived cost burden (1fx: RABCN= 32, nonRABCN= 27; 2-5fx: RABCN= 7, nonRABCN= 38) and travel distance (1fx: RABCN= 34, nonRABCN= 28; 2-5fx: RABCN= 7, nonRABCN= 38) were compared using a Mann-Whitney U Test. Travel distance was also compared to OOP cost. Patients treated with 6+ fractions were excluded. Results: Median estimated OOP cost was significantly lower for 1fx RABC patients vs. 1fx non-RABC patients ($450 [IQR $187.5-$1,050] vs. $2,000 [$625-$4,000]; p = 0.008), but there was no significant difference for 2-5fx ($1,900 vs. $1,375; p = 0.593). Overall patient satisfaction with cost burden was high regardless of treatment setting (1fx: 10 [8-10]; 2-5fx: 10 [8-10]). Median travel distance was not significantly different between clinics (1fx: 245 [39.8-351.5] vs. 262.5 [83-879.3], p = 0.3651; 2-5fx: 274 [36-1293] vs. 176 [25-626], p = 0.2721). Travel distance was directly correlated with out of pocket cost for single fraction (1fx: R2= 0.125, p = 0.0109; 2-5fx: R2= 0.037, p = 0.3433). Conclusions: The establishment of a RABC at MDACC significantly decreased financial toxicity for 1fx patients receiving palliative RT, but not in the 2-5fx cohort. Increased financial toxicity was associated with longer travel distance for 1fx palliative radiation. Implementation of a similar model in local community centers may decrease financial toxicity for patients receiving palliative radiation.
42
Prokhorikhin, A. A., E. I. Fartakov, D. U. Malaev, A. A. Boykov, S. V. Oidup-Ool, V. I. Baystrukov, I. O. Grazhdankin, D. D. Zubarev, E. A. Pokushalov, and E. I. Kretov. "Efficacy and safety of bioresorbable vascular scaffold Absorb: 6-month outcomes of GABI-R: Russia registry." Patologiya krovoobrashcheniya i kardiokhirurgiya 23, no. 1S (May 2, 2019): 26. http://dx.doi.org/10.21688/1681-3472-2019-1s-s26-s33.
Анотація:
<p><strong>Aim.</strong> The paper demonstrates the interim analysis of efficacy and safety after everolimus-eluting bioresorbable vascular scaffold (BVS) Absorb implantation in “real-world patients” with coronary artery disease.</p><p><strong>Methods.</strong> A cohort of 500 consecutive patients who underwent percutaneous coronary intervention for stable chest pain or acute coronary syndrome with implantation of at least one BVS (Absorb, Abbott Vascular) and followed up by telephone interview and review of medical charts were included in a singlecenter, prospective, all-comers, first in Russia registry. The primary endpoint, target vessel failure, defined as the combination of cardiac death, target vessel myocardial infarction, or clinically driven target vessel revascularization and secondary endpoints, MACCE (composite of cardiovascular death, myocardial infarction, coronary artery bypass surgery, target vessel revascularization, stroke) and stent thrombosis, were assessed during 6-month follow-up.</p><p><strong>Results</strong>. A total of 500 patients with coronary artery disease (CAD) (stable CAD 54.4%, acute coronary syndrome 45.6%) and different amount of affected vessels (1 vessel CAD 40.8%, n = 204; 2-vessel CAD 32.8%, n = 164; 3-vessel CAD 26.4%, n = 132) received 664 scaffolds and 55 stents in 603 stenoses. Procedure success, defined as a residual stenosis less than 30% and TIMI 3 flow in target vessel at the end of procedure, was observed in 98.51% (n = 594). At the moment of 6-month follow-up 4.2% (n = 24) of patients were lost to contact. After 6 months, incidence of target vessel failure and MACCE was 4.2% (n = 21) and 5% (n = 25). The cumulative rate of definite/probable scaffold thrombosis was 1.6% (n = 8).</p><p><strong>Conclusion</strong>. The interim analysis of Gabi-R: Russia registry, the largest trial of BVS Absorb implantation in routine clinical practice, showed high procedural success and low incidence of adverse events during follow-up. However, a tendency to high incidence of scaffold thrombosis compared to drug-eluting stents can be observed. Considering the long-term results of randomized trials retrospective registries, safety in terms of BVS routine use is of big concern. Longterm 24-month data regarding safety endpoints are required to test the afore-mentioned suggestion. </p><p>Received 5 January 2019. Revised 28 March 2019. Accepted 29 March 2019.</p><p>Funding: The study did not have sponsorship.</p><p>Conflict of interest: Authors declare no conflict of interest.</p>
43
YOUART, ALYSSA M., YANG HUANG, CYNTHIA M. STEWART, ROBIN M. KALINOWSKI, and J. DAVID LEGAN. "Modeling Time to Inactivation of Listeria monocytogenes in Response to High Pressure, Sodium Chloride, and Sodium Lactate." Journal of Food Protection 73, no. 10 (October 1, 2010): 1793–802. http://dx.doi.org/10.4315/0362-028x-73.10.1793.
Анотація:
A mathematical model was developed to predict time to inactivation (TTI) by high pressure processing of Listeria monocytogenes in a broth system (pH 6.3) as a function of pressure (450 to 700 MPa), inoculum level (2 to 6 log CFU/ml), sodium chloride (1 or 2%), and sodium lactate (0 or 2.5%) from a 4°C initial temperature. Ten L. monocytogenes isolates from various sources, including processed meats, were evaluated for pressure resistance. The five most resistant strains were used as a cocktail to determine TTI and for model validation. Complete inactivation of L. monocytogenes in all treatments was demonstrated with an enrichment method. The TTI increased with increasing inoculum level and decreasing pressure magnitude, from 1.5 min at 700 MPa and 2 log CFU/ml, to 15 min at 450 MPa and 6 log CFU/ml. Neither NaCl nor sodium lactate significantly influenced TTI. The model was validated with ready-to-eat, uncured, Australian retail poultry products, and with product specially made at a U.S. Department of Agriculture, Food Safety and Inspection Service (FSIS)–inspected pilot plant in the United States. Data from the 210 individual product samples used for validation indicate that the model gives “fail-safe” predictions (58% with response as expected, 39% with no survivors where survivors expected, and only 3% with survivors where none were expected). This model can help manufacturers of refrigerated ready-to-eat meats establish effective processing criteria for the use of high pressure processing as a postlethality treatment for L. monocytogenes in accordance with FSIS regulations.
44
Augustsson, J., M. Neovius, C. Cullinane-Carli, S. Eksborg, and R. F. van Vollenhoven. "Patients with rheumatoid arthritis treated with tumour necrosis factor antagonists increase their participation in the workforce: potential for significant long-term indirect cost gains (data from a population-based registry)." Annals of the Rheumatic Diseases 69, no. 01 (May 25, 2009): 126–31. http://dx.doi.org/10.1136/ard.2009.108035.
Анотація:
Objective:To investigate the effect of tumour necrosis factor (TNF) antagonist treatment on workforce participation in patients with rheumatoid arthritis (RA).Methods:Data from the Stockholm anti-TNFα follow-up registry (STURE) were used in this observational study. Patients with RA (n = 594) aged 18–55 years, (mean (SD) 40 (9) years) followed for up to 5 years were included with hours worked/week as the main outcome measure. Analyses were performed unadjusted and adjusted for baseline age, disease duration, Health Assessment Questionnaire (HAQ), 28-joint Disease Activity Score (DAS28) and pain score.Results:At baseline patients worked a mean 20 h/week (SD 18). In unadjusted analyses, significant improvements in hours worked/week could already be observed in patients at 6 months (mean, 95% CI) +2.4 h (1.3 to 3.5), with further increases compared to baseline at 1-year (+4.0 h, 2.4 to 5.6) and 2-year follow-up (+6.3 h, 4.2 to 8.4). The trajectory appeared to stabilise at the 3-year (+6.3 h, 3.6 to 8.9), 4-year (+5.3 h, 2.3 to 8.4) and 5-year follow-up (+6.6 h, 3.3 to 10.0). In a mixed piecewise linear regression model, adjusted for age, sex, baseline disease activity, function and pain, an improvement of +4.2 h/week was estimated for the first year followed by an added improvement of +0.5 h/week annually during the years thereafter. Over 5 years of treatment, the expected indirect cost gain corresponded to 40% of the annual anti-TNF drug cost in patients continuing treatment.Conclusion:Data from this population-based registry indicate that biological therapy is associated with increases in workforce participation in a group typically expected to experience progressively deteriorating ability to work. This could result in significant indirect cost benefits to society.
45
Gridina, М. S., О. V. Burmistrov, М. I. Ivantsov, М. А. Gubanov, and А. А. Pimenov. "Formation of Cobalt-Containing Dispersions in Liquid-Metal Systems." Chemistry and Technology of Fuels and Oils 628, no. 6 (2021): 30–34. http://dx.doi.org/10.32935/0023-1169-2021-628-6-30-34.
Анотація:
Cobalt-containing dispersions were formed based on tin, bismuth, gallium, and a bismuth / tin alloy. The effect of the nature of the dispersion medium on the formation of the cobalt-containing dispersed phase has been established. The effect of the method of introducing the cobalt-containing component on the stability of the dispersion is shown. The effect of the concentration of the precursor solution on the size of cobalt oxide particles formed during the formation of a dispersed system has been studied. The fundamental possibility of the formation of catalytic systems based on gallium with a particle size of 450–540 nm is showns.
46
Virolainen, Yana A., Yury M. Timofeyev, Vladimir S. Kostsov, Dmitry V. Ionov, Vladislav V. Kalinnikov, Maria V. Makarova, Anatoly V. Poberovsky, et al. "Quality assessment of integrated water vapour measurements at the St. Petersburg site, Russia: FTIR vs. MW and GPS techniques." Atmospheric Measurement Techniques 10, no. 11 (November 22, 2017): 4521–36. http://dx.doi.org/10.5194/amt-10-4521-2017.
Анотація:
Abstract. The cross-comparison of different techniques for atmospheric integrated water vapour (IWV) measurements is the essential part of their quality assessment protocol. We inter-compare the synchronised data sets of IWV values measured by the Bruker 125 HR Fourier-transform infrared spectrometer (FTIR), RPG-HATPRO microwave radiometer (MW), and Novatel ProPak-V3 global navigation satellite system receiver (GPS) at the St. Petersburg site between August 2014 and October 2016. As the result of accurate spatial and temporal matching of different IWV measurements, all three techniques agree well with each other except for small IWV values. We show that GPS and MW data quality depends on the atmospheric conditions; in dry atmosphere (IWV smaller than 6 mm), these techniques are less reliable at the St. Petersburg site than the FTIR method. We evaluate the upper bound of statistical measurement errors for clear-sky conditions as 0.29 ± 0.02 mm (1.6 ± 0.3 %), 0.55 ± 0.02 mm (4.7 ± 0.4 %), and 0.76 ± 0.04 mm (6.3 ± 0.8 %) for FTIR, GPS, and MW methods, respectively. We propose the use of FTIR as a reference method under clear-sky conditions since it is reliable on all scales of IWV variability.
47
Edwards, B. J., A. Desai, J. Tsai, H. Du, G. R. Edwards, A. D. Bunta, A. Hahr, M. Abecassis, and S. Sprague. "Elevated Incidence of Fractures in Solid-Organ Transplant Recipients on Glucocorticoid-Sparing Immunosuppressive Regimens." Journal of Osteoporosis 2011 (2011): 1–8. http://dx.doi.org/10.4061/2011/591793.
Анотація:
This study was conducted to assess the occurrence of fractures in solid-organ transplant recipients.Methods. Medical record review and surveys were performed. Patients received less than 6 months of glucocorticoids.Results. Of 351 transplant patients, 175 patients provided fracture information, with 48 (27.4%) having fractured since transplant (2–6 years). Transplants included 19 kidney/liver (50% male), 47 kidney/pancreas (53% male), 92 liver (65% male), and 17 pancreas transplants (41% male). Age at transplant was50.8±10.3years. Fractures were equally seen across both genders and transplant types. Calcium supplementation (n=94) and bisphosphonate therapy (n=52) were observed, and an association with a lower risk of fractures was noted for bisphosphonate users (OR=0.4595% C.I. 0.24, 0.85). Fracture location included 8 (16.7%) foot, 12 (25.0%) vertebral, 3 (6.3%) hand, 2 (4.2%) humerus, 5 (10.4%) wrist, 10 (20.8%) fractures at other sites, and 7 (14.6%) multiple fractures. The estimated relative risk of fracture was nearly seventeen-times higher in male liver transplant recipients ages 45–64 years compared with the general male population, and comparable to fracture rates on conventional immunosuppressant regimens.Conclusion. We identify a high frequency of fractures in transplant recipients despite limited glucocorticoid use.
48
Ridoutt, Bradley G., Danielle Baird, Kim Anastasiou, and Gilly A. Hendrie. "An assessment of the water use associated with Australian diets using a planetary boundary framework." Public Health Nutrition 24, no. 6 (February 24, 2021): 1570–75. http://dx.doi.org/10.1017/s1368980021000483.
Анотація:
AbstractObjective:Agriculture accounts for around 70 % of global freshwater withdrawals. As such, the food system has been identified as a critical intervention point to address water scarcity. Various studies have identified dietary patterns that contribute less to water scarcity. However, it is unclear what level of reduction is necessary to be considered sustainable. The pursuit of unnecessarily aggressive reductions could limit dietary diversity. Our objective was to assess the sustainability of water use supporting Australian dietary habits and the adequacy of current dietary guidelines.Design:Dietary intake data were obtained from the National Nutrition and Physical Activity component of the Australian Health Survey. For each individual daily diet, the water scarcity footprint was quantified, following ISO14046:2014, as well as a diet quality score. Water scarcity footprint results were compared with the planetary boundary for freshwater use downscaled to the level of an individual diet.Setting:Australia.Participants:9341 adults participating in the Australian Health Survey.Results:Dietary water scarcity footprints averaged 432·6 L-eq (95 % CI 432·5, 432·8), less than the 695 litres/person per d available to support the current global population of 7·8 billion, and the 603 litres/person per d available for a future population of 9 billion. Diets based on the Australian Dietary Guidelines required 521 L-eq/d, or 379 L-eq/d with lower water scarcity footprint food choices.Conclusions:Diets based on the Australian Dietary Guidelines were found to be within the freshwater planetary boundary. What is needed in Australia is greater compliance with dietary guidelines.
49
Veenstra, Christine Marie, Andrew J. Epstein, Craig Evan Pollack, and Katrina Armstrong. "Does hospital academic status impact colon cancer care value?" Journal of Clinical Oncology 32, no. 30_suppl (October 20, 2014): 6. http://dx.doi.org/10.1200/jco.2014.32.30_suppl.6.
Анотація:
6 Background: Given the high cost of cancer care, delivery of high-value care is crucial. The effect of hospital academic status on value of care for patients with stage II and III colon cancer is unknown. Methods: SEER-Medicare cohort study of 20,118 patients age 66+ with stage II or III colon cancer diagnosed 2000-2005 and followed through December 31, 2007. Patients were assigned to a treating hospital based on hospital affiliation of the primary oncologist. We constructed Kaplan-Meier curves to assess unadjusted overall survival. We estimated a Cox proportional hazards model to assess adjusted overall survival. To examine associations between hospital academic status and mean cost of care we estimated a generalized linear model (GLM) with log link and gamma family. We estimated quantile regression models to examine associations between hospital teaching status and cost at various quantiles (25th, 50th, 75th, 90th, 95th, 99th, 99.5th, 99.9th). Standard errors were adjusted to account for clustering of patients within hospitals. Results: 4449/20,118 (22%) patients received care from providers affiliated with academic hospitals. There was no significant difference in unadjusted median survival based on hospital academic status for patients with stage II (academic 6.4 yrs vs. non-academic 6.3 yrs, p=0.711) or stage III disease (academic 4.2 yrs vs. non-academic 4.2 yrs, p=0.81). After adjustment, treatment at academic hospitals was not associated with significantly reduced risk of death from colon cancer (stage II HR 1.05, 95% CI: 0.97 - 1.13; p=0.23; stage III HR 0.99, 95% CI: 0.94-1.07; p=0.98). Excepting stage III patients at the 99.9th percentile of costs, there were no significant differences in adjusted costs between academic and non-academic hospitals. Conclusions: We find no difference in overall survival for patients with stage II or stage III colon cancer based on academic status of the treating hospital. Furthermore, costs of care are similar between academic and non-academic hospitals across virtually the full range of the cost distribution. Most colon cancer patients do not receive cancer care at academic hospitals. Our findings indicate that for patients with stage II or III disease, this inequity does not impact the value of care.
50
Yamamoto, Naohito, Hiroyasu Yamashiro, Hiroji Iwata, Norikazu Masuda, Shoichiro Ohtani, Masato Takahashi, Kosuke Yamazaki, et al. "Safety of trastuzumab in HER2-positive primary breast cancer in Japan: Initial safety report for the large-scale cohort study (JBCRG C-01)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 613. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.613.
Анотація:
613 Background: The global randomized trials with trastuzumab (H) shows increased cardiotoxicity in patients (pts) with HER2 positive early breast cancer (BC). Safety in Japanese has not been fully evaluated. We evaluated the safety, especially focused on cardiotoxicity, of H adjuvant (adj) therapy in an observational study in Japan (UMIN000002737). Methods: Pts with histopathologically confirmed HER2 positive invasive BC were registered. Women with stage I-IIIC disease who received H as neo-adj and/or adj therapy were eligible. Mean LVEF at 3, 6, 9 and 18 months (M) was evaluated. The time points represent examination on day 60-120, 150-210, 240-330 and 455-635, respectively. Results: A total of 2024 pts were registered from 56 institutes between July 2009 and June 2011. Data of 1875 pts were collected and finalized by September 2012, and 1800 of them were analyzed for safety. The median follow-up was 35 M. The mean age was 54.5 years. Elderly pts ≥60 years were 32.7%. Treatments after surgery were: concurrent chemotherapy (CT) and H in 20.1%, sequential CT and H in 43.5% and H monotherapy in 35.9%. Adverse events (AEs) associated with H were reported in 350 pts (19.4%) and grade (G) 3/4 AEs in 12 pts (0.7%). G 3/4 cardiotoxicity was reported in 7 pts (dysfunction, 4pts; angina, 1 pt; myocardial infarction, 1 pt and heart failure, 1 pt). The mean LVEF at the baseline was 69.4%. Mean LVEF at 3, 6, 9 and 18M were 66.9%, 66.3%, 65.3% and 66.3%, respectively. Compared to the baseline, LVEF decreased with significant difference at all time points (p<0.0001). LVEF decrease ≥10% occurred in 177 pts (during H treatment,130 and after H treatment, 47). Follow-up data were available in 66 pts: 34 pts recovered to the baseline. Mean time to recover was 262 days. The univariate analysis showed using anthracycline (odds ratio 2.312, p=0.003) was the only risk factor for cardiotoxicity. However, elderly, radiation concurrent/sequential treatment with CT and H had no impact. Conclusions: From our study, we found the AE profiles of H were consistent with previously known AEs. We found using anthracycline was the risk factor for cardiotoxicity at the moment. We should carefully follow pts and watch long-term safety. Clinical trial information: 000002737.