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Magalhães, Lana Cynthia Silva, Ricardo Cesar Correa Cabral, Daniel Praia Portela de Aguiar, Cecilia Veronica Nunez, Jair Max Furtunato Maia, and Maria Clara Silva-Forsberg. "Distribution of invasive exotic species Artocarpus heterophyllus Lam. in a forest fragment in the Amazon." Research, Society and Development 11, no. 3 (March 8, 2022): e59011326734. http://dx.doi.org/10.33448/rsd-v11i3.26734.
Анотація:
Artocarpus heterophyllus is an invasive exotic species known for its negative impacts on Brazilian ecosystems. The aim of this study was to evaluate the distribution and population structure of A. heterophyllus in the plant community of a forest fragment in the Amazon. Individuals of this species were subject to active search at Sumaúma State Park, in Manaus, and two plots were delimited, where these individuals were counted. In each plot, the jackfruit tree individual with the largest Diameter at Breast Height (DBH) was centralized, and from it, native species were inventoried. The parameters of relative density, relative dominance and the importance value index were estimated. Jackfruit tree individuals in the plots had grouped distribution and their number in plots 1 and 2 was 308 and 872 individuals, respectively. In quadrant 1, 254 jackfruit trees and 118 native individuals were recorded, and in quadrant 2, 629 jackfruit and 130 native individuals. The jackfruit tree reached indices higher than the sum of the phytosociological indices of all native species. Jackfruit tree distribution was considered similar to that occurring in other already invaded areas of Brazil, which may indicate that the same impacts may occur in Amazonian ecosystems.
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Testori, Alessandro, Zalman Vaksman, Sharon J. Diskin, Hakon Hakonarson, Mario Capasso, Achille Iolascon, John M. Maris, and Marcella Devoto. "Genetic Analysis in African American Children Supports Ancestry-Specific Neuroblastoma Susceptibility." Cancer Epidemiology, Biomarkers & Prevention 31, no. 4 (February 7, 2022): 870–75. http://dx.doi.org/10.1158/1055-9965.epi-21-0782.
Анотація:
Abstract Background: Neuroblastoma is rarer in African American (AA) children compared with American children of European descent. AA children affected with neuroblastoma, however, more frequently develop the high-risk form of the disease. Methods: We have genotyped an AA cohort of 629 neuroblastoma cases (254 high-risk) and 2,990 controls to investigate genetic susceptibility to neuroblastoma in AAs. Results: We confirmed the known neuroblastoma susceptibility gene BARD1 at genome-wide significance in the subset of high-risk cases. We also estimated local admixture across the autosomal genome in the AA cases and controls and detected a signal at 4q31.22 where cases show an increase in European ancestry. A region at 17p13.1 showed increased African ancestry in the subgroup of high-risk cases with respect to intermediate- and low-risk cases. Using results from our published European American (EA) genome-wide association study (GWAS), we found that a polygenic score that included all independent SNPs showed a highly significant association (P value = 1.8 × 10−73) and explained 19% of disease risk variance in an independent EA cohort. In contrast, the best fit polygenic score (P value = 3.2 × 10−11) in AAs included only 22 independent SNPs with association P value < 2.75 × 10−6 in the EA GWAS, and explained 2% of neuroblastoma risk variance. The significance of the polygenic score dropped rapidly with inclusion of additional SNPs. Conclusions: These findings suggest that several common variants contribute to risk of neuroblastoma in an ancestry-specific fashion. Impact: This work supports the need for GWAS to be performed in populations of all races and ethnicities.
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Yu, Hongfan, Qingsong Yu, Yuxian Nie, Wei Xu, Yang Pu, Wei Dai, Xing Wei, and Qiuling Shi. "Data Quality of Longitudinally Collected Patient-Reported Outcomes After Thoracic Surgery: Comparison of Paper- and Web-Based Assessments." Journal of Medical Internet Research 23, no. 11 (November 9, 2021): e28915. http://dx.doi.org/10.2196/28915.
Анотація:
Background High-frequency patient-reported outcome (PRO) assessments are used to measure patients' symptoms after surgery for surgical research; however, the quality of those longitudinal PRO data has seldom been discussed. Objective The aim of this study was to determine data quality-influencing factors and to profile error trajectories of data longitudinally collected via paper-and-pencil (P&P) or web-based assessment (electronic PRO [ePRO]) after thoracic surgery. Methods We extracted longitudinal PRO data with 678 patients scheduled for lung surgery from an observational study (n=512) and a randomized clinical trial (n=166) on the evaluation of different perioperative care strategies. PROs were assessed by the MD Anderson Symptom Inventory Lung Cancer Module and single-item Quality of Life Scale before surgery and then daily after surgery until discharge or up to 14 days of hospitalization. Patient compliance and data error were identified and compared between P&P and ePRO. Generalized estimating equations model and 2-piecewise model were used to describe trajectories of error incidence over time and to identify the risk factors. Results Among 678 patients, 629 with at least 2 PRO assessments, 440 completed 3347 P&P assessments and 189 completed 1291 ePRO assessments. In total, 49.4% of patients had at least one error, including (1) missing items (64.69%, 1070/1654), (2) modifications without signatures (27.99%, 463/1654), (3) selection of multiple options (3.02%, 50/1654), (4) missing patient signatures (2.54%, 42/1654), (5) missing researcher signatures (1.45%, 24/1654), and (6) missing completion dates (0.30%, 5/1654). Patients who completed ePRO had fewer errors than those who completed P&P assessments (ePRO: 30.2% [57/189] vs. P&P: 57.7% [254/440]; P<.001). Compared with ePRO patients, those using P&P were older, less educated, and sicker. Common risk factors of having errors were a lower education level (P&P: odds ratio [OR] 1.39, 95% CI 1.20-1.62; P<.001; ePRO: OR 1.82, 95% CI 1.22-2.72; P=.003), treated in a provincial hospital (P&P: OR 3.34, 95% CI 2.10-5.33; P<.001; ePRO: OR 4.73, 95% CI 2.18-10.25; P<.001), and with severe disease (P&P: OR 1.63, 95% CI 1.33-1.99; P<.001; ePRO: OR 2.70, 95% CI 1.53-4.75; P<.001). Errors peaked on postoperative day (POD) 1 for P&P, and on POD 2 for ePRO. Conclusions It is possible to improve data quality of longitudinally collected PRO through ePRO, compared with P&P. However, ePRO-related sampling bias needs to be considered when designing clinical research using longitudinal PROs as major outcomes.
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Parthiban, P., V. Ramkumar, Min Sung Kim, Se Mo Son, and Yeon Tae Jeong. "2,4-Bis(2-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one." Acta Crystallographica Section E Structure Reports Online 65, no. 6 (May 23, 2009): o1383. http://dx.doi.org/10.1107/s1600536809018686.
Анотація:
In the title compound, C22H25NO3, the molecule has a pseudo-mirror plane. The structure is a positional isomer of 2,4-bis(4-methoxyphenyl)-3-azabicyclo[3.3.1]nonan-9-one [Cox, McCabe, Milne & Sim (1985).J. Chem. Soc. Chem. Commun.pp. 626–628]. The 3-azabicyclo[3.3.1]nonan-9-one moiety adopts a double chair conformation with equatorial orientations of both 2-methoxyphenyl substituents on either side of the secondary amino group. The benzene rings are oriented at an angle of 33.86 (4)° with respect to each other and the methoxy groups point towards the carbonyl group. The crystal structure is stabilized by intermolecular N—H...π interactions.
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Dörfler, U., T. D. McGrath, P. A. Cooke, J. D. Kennedy, and M. Thornton-Pett. "2,4-Cl2-6,9-exo,endo-(PMe2Ph)2-arachno-B10H10." Acta Crystallographica Section C Crystal Structure Communications 54, no. 11 (November 15, 1998): 1703–5. http://dx.doi.org/10.1107/s0108270198005666.
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Lai, Byron, Jeffer E. Sasaki, Brenda Jeng, Katie L. Cederberg, Marcas M. Bamman, and Robert W. Motl. "Accuracy and Precision of Three Consumer-Grade Motion Sensors During Overground and Treadmill Walking in People With Parkinson Disease: Cross-Sectional Comparative Study." JMIR Rehabilitation and Assistive Technologies 7, no. 1 (January 16, 2020): e14059. http://dx.doi.org/10.2196/14059.
Анотація:
Background Wearable motion sensors are gaining popularity for monitoring free-living physical activity among people with Parkinson disease (PD), but more evidence supporting the accuracy and precision of motion sensors for capturing step counts is required in people with PD. Objective This study aimed to examine the accuracy and precision of 3 common consumer-grade motion sensors for measuring actual steps taken during prolonged periods of overground and treadmill walking in people with PD. Methods A total of 31 ambulatory participants with PD underwent 6-min bouts of overground and treadmill walking at a comfortable speed. Participants wore 3 devices (Garmin Vivosmart 3, Fitbit One, and Fitbit Charge 2 HR), and a single researcher manually counted the actual steps taken. Accuracy and precision were based on absolute and relative metrics, including intraclass correlation coefficients (ICCs) and Bland-Altman plots. Results Participants walked 628 steps over ground based on manual counting, and Garmin Vivosmart, Fitbit One, and Fitbit Charge 2 HR devices had absolute (relative) error values of 6 (6/628, 1.0%), 8 (8/628, 1.3%), and 30 (30/628, 4.8%) steps, respectively. ICC values demonstrated excellent agreement between manually counted steps and steps counted by both Garmin Vivosmart (0.97) and Fitbit One (0.98) but poor agreement for Fitbit Charge 2 HR (0.47). The absolute (relative) precision values for Garmin Vivosmart, Fitbit One, and Fitbit Charge 2 HR were 11.1 (11.1/625, 1.8%), 14.7 (14.7/620, 2.4%), and 74.4 (74.4/598, 12.4%) steps, respectively. ICC confidence intervals demonstrated low variability for Garmin Vivosmart (0.96 to 0.99) and Fitbit One (0.93 to 0.99) but high variability for Fitbit Charge 2 HR (–0.57 to 0.74). The Fitbit One device maintained high accuracy and precision values for treadmill walking, but both Garmin Vivosmart and Fitbit Charge 2 HR (the wrist-worn devices) had worse accuracy and precision for treadmill walking. Conclusions The waist-worn sensor (Fitbit One) was accurate and precise in measuring steps with overground and treadmill walking. The wrist-worn sensors were accurate and precise only during overground walking. Similar research should inform the application of these devices in clinical research and practice involving patients with PD.
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Derunova, E. A. "Methodical Approaches to the Estimation of Influence of Factors of External and Internal Environment on Consumer Behavior when Selecting High-tech Products." Izvestiya of Saratov University. New Series. Series Economics. Management. Law 13, no. 4(2) (2013): 623–29. http://dx.doi.org/10.18500/1994-2540-2013-13-4-2-623-629.
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Winarno, Ermin Katrin, and Nikola Getoff. "Photo-Induced Decomposition of 2-Chloroaniline in Aqueous Solution." Zeitschrift für Naturforschung C 57, no. 5-6 (June 1, 2002): 512–15. http://dx.doi.org/10.1515/znc-2002-5-619.
Анотація:
A study was performed on the oxidizing degradation of 2-chloroaniline (used as a model pollutant in water) by photolysis (λ = 254 nm). The change of spectrum and substrate concentration of treated solutions was measured spectrophotometrically as well as by HPLC. The yields of the degradation products (chloride ions, ammonium ions, formaldehyde, etc.) were studied as a function of UV-dose. Their initial quantumyields (Qi) were determined by specific analysis. It was shown that the substrate photolysis in the presence of N2O is most efficient, followed by degradation in media saturated with pure oxygen and air. A probable reaction mechanism for the photo-induced degradation of 2-ClA is presented.
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Azenha, M. E. D. G., H. D. Burrows, M. Canle L., R. Coimbra, M. I. Fernández, M. V. García, M. A. Peiteado, and J. A. Santaballa. "Kinetic and mechanistic aspects of the direct photodegradation of atrazine, atraton, ametryn and 2-hydroxyatrazine by 254 nm light in aqueous solution." Journal of Physical Organic Chemistry 16, no. 8 (August 2003): 498–503. http://dx.doi.org/10.1002/poc.624.
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He, Ling, Wei Min Sun, Yu Tian Ding, and Yu Hua Wang. "Synthesis and Photoluminescence Properties of the Novel Red Phosphor Gd2MoB2O9: Eu." Advanced Materials Research 311-313 (August 2011): 1327–31. http://dx.doi.org/10.4028/www.scientific.net/amr.311-313.1327.
Анотація:
A novel phosphor, Gd2MoB2O9:Eu3+ has been synthesized by solid-state reaction and its photoluminescence in UV-VUV range are investigated. A sharp excitation band is observed in the region of 120–135 nm, which is related to the charge-transfer (CT) band of Gd3+. The broad band around 135–160 nm can be assigned to the BO3 host absorption. The broad bands around 248 nm are assigned to the CT band of Eu3+-O2-. The phosphors emit strong red luminescence centered at about 591 nm, 614 nm and 626 nm due to the5D0–7F1 and 5D0–7F2 transitions of Eu3+. The main emission peak under 254 and 147 nm excitations also shows different shifts with increasing Eu3+ concentration. This could be due to the different luminescence sites selected at high doping concentrations of Eu3+. Gd2MoB2O9:Eu3+ shows the pure red emission under both 254 and 147 nm excitations.
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Kobayashi, Roger H., AiLan D. Kobayashi, Napoleon Lee, Susanna Fischer, and Hans D. Ochs. "Home Self-Administration of Intravenous Immunoglobulin Therapy in Children." Pediatrics 85, no. 5 (May 1, 1990): 705–9. http://dx.doi.org/10.1542/peds.85.5.705.
Анотація:
Twelve children with primary immunodeficiency aged 2 to 17 years (mean ± 1 SD = 9.8 ± 5.3), were enrolled in a 9-month study to evaluate the feasibility and safety of home self-infusion of intravenous immunoglobulin (IVIg). An initial 2-month training and supervisory period was followed by a 6-to 7-month period during which the children or their parents infused IVIg in a home setting. Eight children received an average dose of 204 ± 12 mg/kg every 2 weeks, two children received a dose of 400 mg/kg every month, and an additional two children received 240 to 250 mg/kg every 10 days. Peak and trough levels varied from 946 ± 20 mg/dL and 627 ± 16 mg/dL, respectively, in children receiving IVIg every 2 weeks. The peak-trough values for the children receiving IVIg every month were 1105 ± 94 mg/dL and 457 ± 78 mg/dL, while those of children receiving IVIg every 10 days were 840 ± 24 mg/dL and 553 ± 109 mg/dL. A total of 224 infusions were administered, with only two minor reactions occurring (reaction rate of 0.9%). There was no difference in the frequency of infections and antibiotic use during the study compared with the previous phase. The results demonstrate that home self-infusion of IVIg in children is safe and feasible.
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Miškinienė, Galina. "Lina Lieparskienė, Arūnas Baltėnas. Vietiniai. Nepaprasta kelionė į Trakų kraštą." Slavistica Vilnensis 64, no. 2 (December 20, 2019): 148–51. http://dx.doi.org/10.15388/slavviln.2019.64(2).28.
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Ferreira, Mari Cassol, Camila Piaia, Ana Carolina Cadore, Marinez Amabile Antoniolli, Geni Portela Gamborgi, and Patrícia Pereira de Oliveira. "Clinical variables associated with depression in patients with type 2 diabetes." Revista da Associação Médica Brasileira 61, no. 4 (August 2015): 336–40. http://dx.doi.org/10.1590/1806-9282.61.04.336.
Анотація:
SummaryBackground:the aim of the study was to evaluate the relationship between type 2 diabetes (T2DM), depression and depressive symptoms and their clinical impact on T2DM.Methods:the authors evaluated 214 outpatients, 105 with diabetes (T2DM group) and 109 non-diabetics (control group), with ages ranging between 50 and 75 years (T2DM group 65.1 ± 5.6 years, control group 63.4 ± 5.8 years). Use of antidepressant treatment or score ≥ 16 on the Beck depression inventory (BDI) was considered depression. Complications of diabetes and total symptom score (TSS) for peripheral neuropathy were reported by patients.Results:diabetes group had a higher frequency of depression (35.2%) compared to controls (21.1%) (p=0,021), with 2.4 times increased risk of depression. The presence of depressive symptoms was also higher in T2DM group (mean BDI 9.5 ± 8.8 versus 6.9 ± 6.2; p=0.039). Symptoms of diabetic neuropathy were higher in depressed subjects. The metabolic control and presence of complications in T2DM group were not associated with depression.Conclusion:T2DM led to an increased risk of depression, but this did not influence the metabolic control or the presence of other complications.
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Freislich, Mary Ruth, and A. Bowen-James. "Effects of a change to more formative assessment among tertiary mathematics students." ANZIAM Journal 61 (September 2, 2020): C255—C272. http://dx.doi.org/10.21914/anziamj.v61i0.15166.
Анотація:
A change in teaching delivery at a large Australian university, from two semesters to three trimesters, was the occasion for using more formative assessment in a core first-year mathematics unit. This study compared evidence about learning outcomes for two cohorts in adjacent years. Cohort 1 was the last taught over a semester, and Cohort 2 the first taught over a trimester. There was no change in overall workload, and no change in the unit's total teaching hours, syllabus or materials. Assessments were changed for class tests during the teaching period by giving Cohort 2 access to unlimited practice and computer-assisted feedback on the questions in the test database, followed by doing the tests under examination conditions. For Cohort 2, a written assignment was also added, focused on giving a clear solution to a mathematics problem, and awareness of the need for appropriate evidence, both background and internal to the problem. Learning outcomes were compared using closely comparable tasks from the final examinations, and examining students' answers in the examination scripts. Outcomes were assessed by a method derived from the solo taxonomy, which afforded a common scale to measure the quality of learning outcomes observable in final examination scripts. Results on separate tasks, plus those for a composite score, favoured Cohort 2. The effect size for the composite score was 0.457. This indicates that the unlimited practice with computer feedback for class tests, and the writing assignment, were functioning as intended in promoting learning with understanding. References S. Bengmark, H. Thunberg, and T. M. Winberg. Success-factors in transition to university mathematics. Int. J. Math. Ed. Sci. Tech., 48(7):988–1001, 2017. doi:10.1080/0020739X.2017.1310311. J. B. Biggs and K. F. Collis. Evaluating the quality of learning: The SOLO taxonomy. Academic Press, New York, 1981. URL https://www.elsevier.com/books/evaluating-the-quality-of-learning/biggs/978-0-12-097552-5. A. Bowen-James. Perceptions of learning environments among tertiary mathematics students. Sc.Ed.D. Thesis. Curtin University of Technology, 2002. H. Chick, J. M. Watson, and K. F. Collis. Using the solo taxonomy for error analysis in mathematics. Res. Math. Ed. Aust., 1(1):34–47, 1988. M. R. Freislich. A comparison between the effects of Keller Plan instruction and traditional teaching methods on the structure of learning outcomes among tertiary mathematics students. Sc.Ed.D. Thesis. Curtin University of Technology, 1997. M. R. Freislich. The effects of Keller Plan instruction on the achievement and attitudes of tertiary mathematics students. Proc. Int. Conf. Teach. Math., Istanbul. 2006. M. Gill and M. Greenow. How effective is feedback in computer-aided assessment? Learn. Media Tech., 33(3):207–220, 2008. doi:10.1080/17439880802324145. J. Hannah, A. James, and P. Williams. Does computer-aided formative assessment improve learning outcomes? Int. J. Math. Ed. Sci. Tech., 45(2):269–281, 2014. doi:10.1080/0020739X.2013.822583. D. Harris and M. Pampaka. \T1\textquoteleft they [the lecturers] have to get through a certain amount in an hour\T1\textquoteright : first year students\T1\textquoteright problems with service mathematics lectures. Teach. Math. App., 35(3):144–158, 2016. doi:10.1093/teamat/hrw013. S. Higgins and M. Katsipataki. Communicating comparative findings from meta-analysis in educational research: some examples and suggestions. Int. J. Math.. Res. Meth. Ed., 39(3):237–254, 2016. doi:10.1080/1743727X.2016.1166486. P. W. Hillock and R. N. Khan. A support learning programme for first-year mathematics. Int. J. Math. Ed. Sci. Tech., 50(7):24–29, 2019. doi:10.1080/0020739X.2019.1656830. A. Hodge, J. C. Richardson, and C. S. York. The impact of a web-based homework tool in university algebra courses on student learning and strategies. J. Online Learn. Teach., 5(4):618–629, 2009. URL https://jolt.merlot.org/vol5no4/hodge_1209.htm. D. Holton and D. Clarke. Scaffolding and metacognition. Int. J. Math. Ed. Sci. Tech., 37(2):127–143, 2006. doi:10.1080/00207390500285818. A. H. Jonsdottir, A. Bjornsdottir, and G. Stefansson. Difference in learning among students doing pen-and-paper homework compared to web-based homework in an introductory statistics course. J. Stat. Ed., 25(1):12–20, 2017. doi:10.1080/10691898.2017.1291289. M. McAlinden and A. Noyes. Mathematics in the disciplines at the transition to university. Teach. Math. App., 38(2):61–73, 2019. doi:10.1093/teamat/hry004. J. Nicholas, L. Poladian, J. Mack, and R. Wilson. Mathematics preparation for university: entry pathways and their effect on performance in first year mathematics and science subjects. Int. J. Innov. Sci. Math. Ed., 23(1):37–51, 2015. https://openjournals.library.sydney.edu.au/index.php/CAL/article/view/8488. M. I. Nunez-Pena, R. Bono, and M. Suarez-Pellicioni. Feedback on students' performance: a possible way of reducing the negative effect of math anxiety in higher education. Int. J. Ed. Res., 70(1):80–87, 2015. doi:10.1016/j.ijer.2015.02.005. J. T. E. Richardson. Student learning in higher education: a commentary. Ed. Psych. Rev., 29(1):353–362, 2017. doi:10.1007/s10648-017-9410-x. L. J. Rylands and D. Shearman. Mathematics learning support and engagement in first year engineering. Int. J. Math. Ed. Sci. Tech., 49(8):1133–1147, 2018. doi:10.1080/0020739X.2018.1447699. K. A. Seaton. Efficacy and efficiency in formative assessment: an informed reflection on the value of partial marking. Int. J. Math. Ed. Sci. Tech., 44(7):963–971, 2013. doi:10.1080/0020739X.2013.831490. D. Wood, J. S. Bruner, and G. Ross. The role of tutoring in problem solving. J. Child Psychol. Psych., 17(1):89–100, 1976. doi:10.1111/j.1469-7610.1976.tb00381.x. L. Zetterqvist. Applied problems and use of technology in an aligned way in basic courses in probability and statistics for engineering students—a way to enhance understanding and increase motivation. Teach. Math. App., 36(2):108–122, 2017. doi:10.1093/teamat/hrx004.
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Green, J. H., and M. F. Muers. "Comparisons between basal metabolic rate and diet-induced thermogenesis in different types of chronic obstructive pulmonary disease." Clinical Science 83, no. 1 (July 1, 1992): 109–16. http://dx.doi.org/10.1042/cs0830109.
Анотація:
1. Some patients with the emphysematous type of tobacco-related chronic obstructive pulmonary disease are hypermetabolic. Since the likely mechanism is the increased work of breathing, other groups of patients with chronic obstructive pulmonary disease should be similar. We have now measured basal metabolic rate and diet-induced thermogenesis in six patients with chronic obstructive pulmonary disease with an arterial partial pressure of CO2 of <5kPa (emphysematous), nine patients with chronic obstructive pulmonary disease with an arterial partial pressure of CO2 of >6kPa (bronchitic), eight patients with chronic obstructive pulmonary disease due to chronic asthma and seven control subjects. Diet-induced thermogenesis was measured for 4h after a meal of 87% carbohydrate, 11% protein and 2% fat as energy, with a total energy content of 40% of basal metabolic rate. 2. There was no difference between measured and predicted basal metabolic rate in the control (5541 ± 272 versus 5881 ± 245 kJ/24h) or emphysematous (5552 ± 370 versus 6239 ± 197 kJ/24 h) groups, but measured basal metabolic rate was significantly higher than predicted in the bronchitic (6126 ± 387 versus 5405 ± 250 kJ/24 h) and asthmatic (6293 ± 197 versus 5701 + 245, mean ± SEM, P<0.01) groups. All the control subjects had measured basal metabolic rates within 10% of predicted, whereas two out of six emphysematous patients, four out of nine bronchitic patients and five out of eight asthmatic patients were hypermetabolic. The contributions of fat, carbohydrate and protein oxidation rates to the overall basal metabolic rate were similar between groups. 3. Diet-induced thermogenesis was similar between groups. The postprandial fuel mix oxidized was also similar between all four groups. 4. Thus, some patients with both types of smoking-related chronic obstructive pulmonary disease and other patients with chronic asthma were hypermetabolic. This could not be predicted from detailed lung function tests, arterial blood gases or anthropometric measurements, and suggests that the increased work of breathing may not be the only cause of the hypermetabolism and weight loss seen in these patients.
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Carsughi, F., R. P. May, R. Plenteda, and J. Saroun. "Sample geometry effects on incoherent small-angle scattering of light water." Journal of Applied Crystallography 33, no. 1 (February 1, 2000): 112–17. http://dx.doi.org/10.1107/s0021889899013643.
Анотація:
Light water is frequently used as a standard for calibrating small-angle neutron scattering (SANS) data. The intensities collected for 1 and 2 mm of light water in standard quartz cells may differ by up to about 50% due to the presence of multiple and inelastic scattering [Rennie & Heenan (1993).Proceedings of ISSI Meeting, Dubna,pp. 254–260, Report E3-93-65; Teixeira (1992).Structure and Dynamics of Strongly Interacting Colloids and Supramolecular Aggregates in Solution, edited by S. H. Chen, pp. 625–658. Dordrecht: Kluwer Academic Publishers]. Multiple scattering increases with the thickness of the sample. The use of only elastically scattered neutrons may lead to an absolute intensity of the SANS data of about a factor of 2 higher than that obtained by taking into account all of the neutrons on the detector [Ghosh & Rennie (1990).Inst. Phys. Conf. Ser.107, 233–244]. However, it is shown here that the scattering intensities collected with different ratios of sample-to-beam dimension do present large differences as a function of sample thickness. In particular, ratios smaller and larger than unity are considered and the results are discussed and compared with Monte Carlo simulations.
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Campo-Sabariz, Joan, David Moral-Anter, M. Teresa Brufau, Mickael Briens, Eric Pinloche, Ruth Ferrer, and Raquel Martín-Venegas. "2-Hydroxy-(4-methylseleno)butanoic Acid Is Used by Intestinal Caco-2 Cells as a Source of Selenium and Protects against Oxidative Stress." Journal of Nutrition 149, no. 12 (August 28, 2019): 2191–98. http://dx.doi.org/10.1093/jn/nxz190.
Анотація:
ABSTRACT Background Selenium (Se) participates in different functions in humans and other animals through its incorporation into selenoproteins as selenocysteine. Inadequate dietary Se is considered a risk factor for several chronic diseases associated with oxidative stress. Objective The role of 2-hydroxy-(4-methylseleno)butanoic acid (HMSeBA), an organic form of Se used in animal nutrition, in supporting selenoprotein synthesis and protecting against oxidative stress was investigated in an in vitro model of intestinal Caco-2 cells. Methods Glutathione peroxidase (GPX) and thioredoxin reductase (TXNRD) activities, selenoprotein P1 protein (SELENOP) and gene (SELENOP) expression, and GPX1 and GPX2 gene expression were studied in Se-deprived (FBS removal) and further HMSeBA-supplemented (0.1–625 μM, 72 h) cultures. The effect of HMSeBA supplementation (12.5 and 625 μM, 24 h) on oxidative stress induced by H2O2 (1 mM) was evaluated by the production of reactive oxygen species (ROS), 4-hydroxy-2-nonenal (4-HNE) adducts, and protein carbonyl residues compared with a sodium selenite control (SS, 5 μM). Results Se deprivation induced a reduction (P < 0.05) in GPX activity (62%), GPX1 expression, and both SELENOP (33%) and SELENOP expression. In contrast, an increase (P < 0.05) in GPX2 expression and no effect in TXNRD activity (P = 0.09) were observed. HMSeBA supplementation increased (P < 0.05) GPX activity (12.5–625 μM, 1.68–1.82-fold) and SELENOP protein expression (250 and 625 μM, 1.87- and 2.04-fold). Moreover, HMSeBA supplementation increased (P < 0.05) GPX1 (12.5 and 625 μM), GPX2 (625 μM), and SELENOP (12.5 and 625 μM) expression. HMSeBA (625 μM) was capable of decreasing (P < 0.05) ROS (32%), 4-HNE adduct (49%), and protein carbonyl residue (75%) production after H2O2 treatment. Conclusion Caco-2 cells can use HMSeBA as an Se source for selenoprotein synthesis, resulting in protection against oxidative stress.
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Firsova, A. A., and O. Yu Chelnokova. "Models of Interaction of University and Region." Izvestiya of Saratov University. New Series. Series Economics. Management. Law 13, no. 4(2) (2013): 619–23. http://dx.doi.org/10.18500/1994-2540-2013-13-4-2-619-623.
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Bartoli, E., A. Satta, F. Melis, M. A. Caria, W. Masala, G. Vargiu, F. Meloni, G. P. Teatini, and G. B. Azzena. "Volume receptors in guinea pig labyrinth: relevance with respect to ADH and Na control." American Journal of Physiology-Renal Physiology 257, no. 3 (September 1, 1989): F341—F346. http://dx.doi.org/10.1152/ajprenal.1989.257.3.f341.
Анотація:
We tested the hypothesis that changes in extracellular fluid volume are reflected by pressure changes within structures of the inner ear and that through neural pathways, a control mechanism exerts an influence on antidiuretic hormone (ADH) release and Na excretion. The study was performed on 35 guinea pigs. In protocol 1, 13 animals were studied before and after decompression of the inner ear by bilateral fluid withdrawal in an experimental setting of sustained isotonic expansion that kept the osmoreceptor partially activated and the intrathoracic volume receptors suppressed. A group of six sham-operated animals served as control. In protocol 2, nine animals were studied before and after a unilateral rise in their inner ear pressure during slightly hypertonic low-rate infusions that kept the osmoreceptor and thoracic volume receptors stimulated. A group of seven sham-operated guinea pigs served as controls. Decompression of the inner ear was attended by a rise in plasma ADH from 11.9 +/- 2.4 to 29.1 +/- 6.9 pg/ml, in urine osmolality (Uosmol) from 470 +/- 48 to 712 +/- 46 mosmol/kg (P less than 0.001), and a fall in urine flow rate (V) from 184 +/- 47 to 71 +/- 11 microliters/min (P less than 0.01), whereas plasma Na (PNa) and osmolality (Posmol) did not change. During inner ear hypertension, plasma ADH fell from 25.6 +/- 3.9 to 18.4 +/- 3.1, Uosmol from 829 +/- 58 to 627 +/- 43 (P less than 0.001), and V rose from 51 +/- 11 to 130 +/- 23 (P less than 0.001), whereas glomerular filtration rate, PNa, and Posmol did not change.(ABSTRACT TRUNCATED AT 250 WORDS)
20
Api, A. M., D. Belsito, D. Botelho, M. Bruze, G. A. Burton, J. Buschmann, M. L. Dagli, et al. "RIFM fragrance ingredient safety assessment, ethyl 2,4-dimethyldioxolane-2-acetate, CAS Registry Number 6290-17-1." Food and Chemical Toxicology 134 (December 2019): 110590. http://dx.doi.org/10.1016/j.fct.2019.110590.
21
Matianova, E., A. Gordeev, and E. Galushko. "AB0346 REASONS FOR DISCONTINUATION OF TNF INHIBITORS IN PATIENTS WITH DIFFICULT-TO-TREAT RHEUMATOID ARTHRITIS ACCORDING TO DRUG HISTORY." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1298–99. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2354.
Анотація:
BackgroundTNF-alpha inhibitors (TNFi) are considered the drugs of choice for initiating biological therapy in rheumatoid arthritis (RA). Rreview of the reasons for their cancellation is included in a comprehensive study of the group of patients (pts) with Difficult to Treat RA (D2T).ObjectivesTo make a comparative assessment of the reasons for discontinuation of TNFi in pts meeting the international EULAR (2021) criteria for D2T, comparing them with other pts who had experience in taking a biological disease modifying antirheumatic drugs (bDMARDs)/targeted synthetic DMARDs (tsDMARDs).MethodsWe analyzed the drug history of 505 pts with RA who were hospitalized at the V.A.Nasonova Research Institute of Rheumatology hospital from January to December 2021(inclusive) due to an RA exacerbation, and who were approved for the introduction of bDMARD/tsDMARD. Pts with no prior experience with bDMARD/tsDMARD were excluded from the analysis (n=179/35.4%). Pts meeting the EULAR criteria for D2T RA (the main of which: failure of two or more bDMARDs/tsDMARDs of different mechanisms of action) were allocated to the D2T group (n=35/6.9%), the rest of the pts made up the control group C (n=291/57.6%). The middle age (±SD) of patients in D2T was less than in C (D2T - 46.3±15.1 years vs. C - 51.6±14.8 years, p=0.047), the duration of RA in the groups was comparable (D2T - 15 .7±10.7 years vs. C – 13.1±8.9 years, р>0.05).ResultsThe frequency of prescribing a history of TNFi in D2T (85.7%) was higher than in C (38.5%; OR=2.9 [1.3-6.6]; p<0.0001). The total duration of their intake (in cases of prescription) and the average number of TNFi drugs in the groups were comparable (p> 0.05), but in D2T pts more often had the experience of taking 3 or more TNFi (OR = 6.4 [2 -20.4]; p=0.002) (Table 1).Table 1.Reasons for discontinuation of TNFi in study groups (n/%)D2T (n=35)C (n=291)рPts taking TNFi in anamnesis, n/%30/ 85,7112/ 38,5<0,0001; OR=9,6 [3,6-25,4]Total duration of taking TNFi М±SD, Me [25; 75 percentile], months22,8±22,5* 15[6;35]23,2±27,5*11[4;34]>0,05Pts taking 3 or more TNFi, n/%8 /26,7*6 /5,4*0,002; OR=6,4 [2-20,4]Cancellation for administrative reasons, n/%2 /6,7*37 /33*0,004 CHI-Square;OR=6,9 [1,6-36,6]Adverse reactions, n/%9 /30*23 /20,5*>0,05insufficient efficiencyTotal28 /93,3*49 /43,8*<0,0001CHI-Square; OR=18 [4,1-79,3]Secondary non-responsiveness to TNFi17 /56,7*35 /31,3*0,01; OR=2,9 [1,3-6,6]Gradual fading effect7 /41,2**22 /62,9**>0,05After the break9 /52,9**7 /20**0,02; OR=4,5 [1,3-15,9]After changing to generic1 /5,9**7 /20**>0,05*the percentage is calculated from the number of pts who took TNFi**percentage calculated from the number of pts with a history of secondary efficacy of any TNFiWithdrawal of TNFi due to their ineffectiveness was more often performed in D2T (93.3%/n=28) than in C (43.8%/n=49; OR=18 [4.1-79.3];p<0.0001). At the same time, secondary non-responsiveness (NR) prevailed in D2T - in 56.7% (17 of 28 cases of NR), which is more often than in C (31.3% / 35 of 49 cases of NR; OR = 18 [4.1-79.3]; p<0.0001).Secondary NR in D2T in 59.9% of pts (9 of 17 cases of secondary NR) developed after the break for administrative reasons in taking a previously effective drug, which is significantly more common than in C (20%/7 of 35 cases of secondary NR; OR = 4.5 [1.3-15.9], p=0.02).Withdrawal of TNFi for administrative reasons was more common in C (33%/n=37 vs. in D2T -6.7%/n=2; OR=6.9 [1.6–36.6]; p =0.004). The incidence of adverse reactions in both groups was comparable (in D2T 30%/n=9 vs. in C - 20.5%/n=23; p>0.05).ConclusionIn patients with D2T RA, TNFi were discontinued more often due to their ineffectiveness (93.3%; compared with C: p<0.0001). This inefficiency was more often secondary (56.7%; compared with C: p=0.01). In the structure of secondary inefficiency, the variant of its development after a break in reception for administrative reasons prevailed (52.9%; compared with C: p=0.02). The incidence of adverse reactions in both groups was comparable.Disclosure of InterestsNone declared
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Millen, J. Eugene, Frederick L. Glauser, and R. Paul Fairman. "A comparison of physiological responses to percussive brain trauma in dogs and sheep." Journal of Neurosurgery 62, no. 4 (April 1985): 587–91. http://dx.doi.org/10.3171/jns.1985.62.4.0587.
Анотація:
✓ Physiological variables were monitored in dogs and sheep after exposure of the brain to a pressure wave produced by a fluid-percussion device. Mean systemic arterial pressure (SAP), mean pulmonary arterial pressure (PAP), and pulmonary wedge pressure (PWP) were recorded prior to and following trauma. Lung lymph flows (QLYM) were measured prior to and for 2 hours after trauma. Plasma catecholamine levels were quantitated prior to and at 30 seconds following trauma. In 16 dogs, SAP increased from 123 ± 14.6 to 254 ± 60.8 mm Hg (p < 0.0001), PAP increased from 17 ± 4.4 to 27 ± 10.8 mm Hg (p < 0.05), and PWP increased from 4 ± 2.4 to 15 ± 8.8 mm Hg (p < 0.0001), all at 30 seconds posttrauma. All pressures returned to near baseline values within 6 minutes. The QLYM from the right lymph duct in 12 dogs increased from 0.82 ± 0.77 to 2.7 ± 2.1 and 1.88 ± 1.82 ml/30 min, respectively, at 30 and 120 minutes. In five dogs the plasma concentrations of dopamine, epinephrine, and norepinephrine increased from 234 ± 98 to 1906 ± 1384, 609 ± 641 to 19,813 ± 10,234, and 388 ± 194 to 3223 ± 992 pg/ml, respectively (all p < 0.01). In sheep there were no changes in SAP, PAP, PWP, QLYM, or catecholamine levels in response to percussive wave trauma up to 10 atm. Ratios of lung tissue water to dry weight were not significantly different from control animals in either species. The authors conclude that in dogs there is a profound sympathetic discharge resulting in dramatic elevations in plasma catecholamines, systemic and pulmonary artery hypertension, and an increase in pulmonary lymph flow. Sheep fail to demonstrate changes in any of these variables after severe percussive wave brain trauma.
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Kutluk, M. Tezer, and Akif Yeşilipek. "Pediatric cancer registry in Turkey 2009-2019 (TPOG & TPHD)." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): e22513-e22513. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e22513.
Анотація:
e22513 Background: The pediatric cancer registry is an essential element of pediatric cancer control. More than 200000 pediatric cancer cases annually are expected in children and adolescents aged 0-14 globally. The current efforts are focusing to improve the survival rates for children and adolescents in LMICs since the survival has already exceeded 80% in most of the high income countries. Here we present the most updated results of the pediatric cancer registry in Turkey. Methods: Pediatric cancer registry has been established by theTurkish Pediatric Oncology Group and Turkish Pediatric Hematology Association in 2002. The childhood cancer cases registered between 2009-2019 was included in this analysis. International Childhood Cancer Classification System was used for the classification. Essential demographic findings, ICD-O-3 morphology and topography codes were recorded for each case. Results: During the 11 years from 2009 to 2019, 17770 cases were registered. For all cases, median age was 6.8 year (0-17; M/F 9973/7789, 3 hermaphrodite, 5 unknown). Age distribution was 0-4 yrs, 40.3%; 5-9 yrs, 24.0%; 10-14 yrs, 23.6%; 15-19 yrs, 12.1%) The distribution of the tumor types were [number of cases, percentage of total, median age yrs, M/F]: Leukemia (4570, 25.7%, 5.5, 2633/1937); Lymphoma & other RES tumors (3477, 19.6%, 9.9, 2324/1150, 1 hermaphrodite & 2 unknown); CNS [brain & spinal] (2493, 14.0%, 6.9, 1363/1129, 1 unkown); Symphatetic system (1426, 8.0%, 2.4, 743/683); Retinoblastoma (348, 2.0%, 1.5, 204/144); Renal (905, 5.1%, 3.2, 435/469, 1 unknown); Liver (304, 1.7%, 1.8, 172/132); Malignant bone (1209, 6.8%, 12.6, 658/551); Soft tissue sarcomas (1221, 6.9%, 7.5, 703/518); Germ cell (1165, 6.6%, 8.8, 426/736, 2 hermaphrodite, 1 unknown); Carcinoma & other malignant epithelial (533, 3.0%, 13.8, 254/279); Other/non-specific malignant (119, 0.7%, 8.5, 58/61). Five year survival rate was found as 71.9%. Conclusions: The data is the most essential part of the cancer control.This registry has been used widely among professionals since its establishment in 2002. Survival rates for children and adolescents has been improved to 70%. This is at the acceptable level for the income level of Turkey which is classified as an upper middle income country. The registry is a useful source for investigators and decision makers at national and international level.
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Biebuyck, X. A. "Comparison of Azithromycin and Co-Amoxiclav in the Treatment of Acute Tracheobronchitis and Acute Infectious Exacerbations of Chronic Bronchitis in Adults." Journal of International Medical Research 24, no. 5 (September 1996): 407–18. http://dx.doi.org/10.1177/030006059602400502.
Анотація:
Azithromycin, a broad-spectrum azalide, and co-amoxiclav were compared in a randomized, multicentre, open-label trial in 759 patients treated for acute tracheobronchitis ( n = 620) or acute infectious exacerbations of chronic bronchitis ( n = 139). Patients were randomized (2:1) to a 3-day regimen of two azithromycin 250 mg capsules once daily or a 5–10-day regimen of co-amoxiclav, one 625 mg tablet three times daily. Azithromycin produced a significantly higher cure rate (70.6% versus 61.1%) than ( P = 0.011) and there were fewer failures (7.8% versus 13.6%) and relapses in the azithromycin-treated group, giving a higher overall response rate for azithromycin (89.7% versus 80.2%, P = 0.0003). With azithromycin, compliance was better than with co-amoxiclav and there was a significantly shorter time to improvement or cure. A higher incidence of adverse events, mostly gastrointestinal, was reported by patients taking co-amoxiclav (21.3% versus 14%, P = 0.0097), causing more patients in this group to discontinue therapy (7% versus 1.2%, P = 0.00004).
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Pati, Nalini K., Frances Garvin, Vicki Antonenas, Ian Kerridge, Kenneth F. Bradstock, and David J. Gottlieb. "Best Approach for Harvesting Bone Marrow to Maximize TNC and CD34+ Cell Counts." Blood 112, no. 11 (November 16, 2008): 3468. http://dx.doi.org/10.1182/blood.v112.11.3468.3468.
Анотація:
Abstract Background: Bone marrow (BM) has been utilized as a source of stem cells for transplantation for many years. Although the use of BM has decreased with the advent of mobilized stem cells, utilization is increasing once again due to the lower rate of chronic GVHD associated with BM as a stem cell source. There is no generally accepted technique for harvesting BM. Protocols vary both in relation to the volume of each aspirate, the number of aspirates performed at each puncture site and the total volume of harvests. Method: BM was collected from the posterior iliac crests (PIC) in 2 separate bags: 10ml aspirates from the left and 20 ml aspirates from the right. Samples taken at the start and after 100, 150, 200, 250, & 500 ml were analyzed for TNC, CD34+ and CD3+ cell counts. Results: The following table shows cell number (mean ± SEM ×106) for the parameters indicated. Aspirate Volume (mls) Parameter Start (n=4) 100mls (2) 150mls (2) 200mls (2) 250mls (4) 500mls (4) 10 TNC 555 ± 28 286 ± 38 257 ± 40 226 ± 8 199 ± 11 158.5±18.5 CD34 5.8 ± 0.05 1.8 ± 0.1 1.7 ± 0.2 1.3 ± 0.4 1.1 ± 0.2 0.8 ± 0.1 CD3 65.8 ± 12.0 35.8 ± 6.9 32.8 ± 8.0 29.9 ± 1.5 28.4 ± 5.1 29.8 ± 6.2 20 TNC 914 ± 52 627 ± 137 458 ± 44 429 ± 113 391 ± 81 264 ± 24 CD34 9.1 ± 0.5 3.8 ± 0.2 2.4 ±0.2 2.7 ± 0.1 2.3 ± 0.7 1.0 ± 0.2 CD3 106.9 ±22.1 64.6 ± 5.3 55.0±14.1 56.5±14.7 53.7±14.6 41.2 ± 9.6 There is a rapid fall in the yield of CD34+ cells obtained with increasing harvest volume (19 and 25% of the initial number after 250 ml for 10 and 20 ml aspirates respectively; 14 and 11% respectively after 500 ml). In contrast the CD3+ cell numbers fall more slowly (43 and 50% after 250 ml, 45 and 38% after 500 ml). By the time 500 ml has been aspirated, there is no difference in the total number of CD34+ cells obtained from a 10 ml versus a 20 ml aspirate of bone marrow. Conclusion: CD34+ cell yields fall rapidly when BM is harvested along the PIC. Using additional areas such as the anterior iliac crests may be preferable to a large volume PIC harvest for optimizing CD34+ stem cell collection. After 500 ml of BM has been harvested, 20 ml BM aspirates do not increase CD34+ cell numbers and 10 ml aspirates should be taken to minimize unnecessary blood loss and reduce T cell contamination.
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Fish, E. M., and B. A. Molitoris. "Extracellular acidosis minimizes actin cytoskeletal alterations during ATP depletion." American Journal of Physiology-Renal Physiology 267, no. 4 (October 1, 1994): F566—F572. http://dx.doi.org/10.1152/ajprenal.1994.267.4.f566.
Анотація:
Extracellular acidosis has been shown to be protective during ischemia in renal tubule cells. However, the mechanism of protection remains unknown. Since ischemia leads to disruption and polymerization of the cortical actin cytoskeleton, we hypothesized acidosis may better preserve the actin cytoskeleton during ischemia. Therefore, the purpose of our studies was to examine the effect of pH on the integrity of the actin cytoskeleton during ATP depletion and ATP repletion. To do this, we used an in vitro model of reversible ATP depletion in LLC-PK1 cells at extracellular pH values (pHo) of 6.9, 7.4, and 7.9. Immunofluorescent studies with rhodamine-phalloidin demonstrated more marked redistribution and clumping of cortical actin at pHo 7.9 and 7.4 vs. 6.9 after 90 min of chemical anoxia. After 15 min of ATP depletion, G-actin, quantified by the deoxyribonuclease assay, decreased from 53.7 +/- 0.8 to 43.2 +/- 1.5 microgram/mg protein at pHo 6.9 vs. 37.6 +/- 1.8 microgram/mg protein at pHo 7.4 (P < 0.001). After 60 min, there still was significantly less conversion of G-actin to F-actin at pHo 6.9 vs. 7.4, with a decrease from 55.9 +/- 2.0 to 39.6 +/- 2.0 micrograms/mg protein at 6.9 vs. 35.8 +/- 2.4 at 7.4 micrograms/mg protein (P < 0.05). Furthermore, extracellular acidosis during the phase of ATP repletion resulted in more rapid normalization of cellular G-actin levels (95 +/- 3% of control vs. 82 +/- 2% for pH 6.9 vs. 7.4, respectively, P < 0.01). Together, these findings indicate the actin cytoskeleton is better preserved in an acidic environment during ATP depletion.(ABSTRACT TRUNCATED AT 250 WORDS)
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Clewley, Robin G., Alfred Fischer, and George N. Henderson. "ipso Nitration in p-halophenyl ethers." Canadian Journal of Chemistry 67, no. 9 (September 1, 1989): 1472–79. http://dx.doi.org/10.1139/v89-224.
Анотація:
Addition of nitronium ion ipso to halogen occurs on nitration of the p-haloanisoles in acetic anhydride at −60 °C. In the cases of p-fluoro- and p-chloro-anisole, addition of the nitronium ion is reversible and only small amounts of ipso products are obtained. With p-bromoanisole nitrodebromination occurs. When p-halophenyl ethers containing a trapping substituent, e.g., 2-(4-chlorophenoxy)-2-methylpropanoic acid, are used as substrates, substantial amounts of the spiro diene with nitro ipso to halogen, e.g., 3,3-dimethyl-8-chloro-8-nitro-1,4-dioxaspiro[4.5]deca-6,9-dien-2-one, can be isolated. The results demonstrate that extensive ipso attack at the halogen-substituted position is general in the nitration of p-halophenyl ethers. Keywords: ipso nitration, ether, diene, p-haloanisole.
28
Diez, J., C. Arozamena, L. Gutierrez, J. Bracco, A. Mon, R. Sanchez Almeyra, and M. Secchi. "Lost Stones During Laparoscopic Cholecystectomy." HPB Surgery 11, no. 2 (January 1, 1998): 105–9. http://dx.doi.org/10.1155/1998/95874.
Анотація:
Background: Gallbladder perforation, with loss of calculi in the abdomen is frequent during laparoscopic cholecystectomy. Recent publications report complications in port sites or in the abdominal cavity. A study of 3686 laparsocopic cholecystectomies performed by 6 surgeons was undertaken. In 627 patients, perforation of the gallbladder occurred and in 254 stones were spilled into the abdominal cavity. In 214 they were retrieved and in 40 left in the abdomen. Twelve patients developed complications. Percutaneous drainage was successful in 2 with serous collections. Two patients with abdominal abscesses were reoperated, stones retrieved and the abdomen drained.One patient developed an intestinal obstruction due to a stone in the ileum. One patient who had a cholecystectomy in another hospital developed a paraumbilical tumor. At reoperation a stone was retrieved. In another six patients, stones were found in port sites. Stones lost into the abdomen should be removed because of their potential morbidity, especially if they are large or if infection is present in the gallbladder at the time of initial surgery. There is no indication for routine conversion to open surgery when stone spillage occurs, although patients should be informed to avoid legal consequence, and to hasten early diagnosis of later complications.
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Otero, A., R. Perry, F. Ewers, and R. T. Fernandez. "609 PB 255 ANATOMICAL CHARACTERIZATION OF ROOT MASS PROLIFERATION OF MARK ROOTSTOCK." HortScience 29, no. 5 (May 1994): 519d—519. http://dx.doi.org/10.21273/hortsci.29.5.519d.
Анотація:
A swelling of the rootstock shank, described as Root Mass Proliferation, has been frequently found in the field on apple trees of Mark rootstock. Swelling usually first appears on trees after they have been established for more than 3 years. The abnormal growth occurs above the soil line on the exposed rootstock shank and it extends to a depth of 10 - 15 cm below soil. Anatomical studies were conducted on maiden nursery trees and trees having been in the orchard for 3 to 6 years with light microscopy. In older trees, changes in normal tissue development occurred in the 2-4 cm outer zone of the swelling surface. Changing direction and proportion of xylem components gives an appearance of tracheiry elements developing in a circular pattern. Abnormal xylem parenchyma seems to have its origin at the xylem parenchyma rays, which follow a straight plain of cell division. Clusters of lignified root initiation points are often found in the outer part of xylem, all around the rootstock shank. Removal of bark and phloem exposes hard nodules, which were found to consist of tracheiry elements surrounded by lignified parenchyma cells all between xylem and phloem tissue encircling the rootstock shank. Abnormal development of xylem vessels suggests that there is an anatomical association between water transport and a reported physiological drought sensitivity of trees on this rootstock.
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Merydith, Erin K., and Leadelle Phelps. "Convergent Validity of the MMPI–A and MACI Scales of Depression." Psychological Reports 105, no. 2 (October 2009): 605–9. http://dx.doi.org/10.2466/pr0.105.2.605-609.
Анотація:
The purpose of this study was to investigate the extent to which the depression scales of the Minnesota Multiphasic Personality Inventory-Adolescents (MMPI–A) and the Millon Adolescent Clinical Inventory (MACI) show convergence with a sample of 252 adolescents from an inpatient psychiatric facility. Both inventories were administered as part of the intake process. Pearson correlations were computed among the (a) MMPI–A Scale 2 (Depression), (b) MMPI–A Depression Content Scale, (c) MACI Doleful Personality Scale, and (d) MACI Depressive Affect Scale. There was no significant difference between the mean scores. Evidence of convergent validity between the two tests was moderate.
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Sandhu, Gurprataap Singh, Anuradha Krishnamurthy, Reed Weiss, Cheryl Lauren Meguid, S. Lindsey Davis, Stephen Leong, Alexis Diane Leal, et al. "Impact of multidisciplinary management in the diagnosis and treatment of neuroendocrine tumors (NET)." Journal of Clinical Oncology 37, no. 4_suppl (February 1, 2019): 629. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.629.
Анотація:
629 Background: The incidence and prevalence of NETs is increasing and diagnosis and pathologic evaluation of NETs is complex. Given the new advances in local and systemic therapies, multidisciplinary management models have been suggested to assist in treatment decisions. However, scientific data showing definite change in management with multidisciplinary clinic (MDC) review is lacking. We aim to address this need in this study. Methods: 113 GI-NET patients from 2012-18 were reviewed from a dedicated MDC where patients are seen simultaneously by multiple subspecialties, and data on patient characteristics, radiology, tumor pathology and treatment strategies were collected. Change in diagnosis was defined as any change in radiographic or pathologic findings that resulted in a change in the tumor type, grade, site or stage of cancer. Change in management was defined as any recommended change in treatment approach for NETs compared to the prior treatment plan. For patients who did not have a prior treatment plan or were seen directly at MDC, a change of management was considered as yes only if there was a change in diagnosis post MDC. Results: The mean age of patients evaluated was 61, with locally advanced or metastatic disease seen in 81% of patients. Small bowel and pancreatic NETs were the most common primaries (36% each). Significant proportion of NETs were well-differentiated (72%) with < 2 mitosis/10 HPF (47.3%) and Ki-67 of < 3% (36%). Patients were referred to MDC at an average of 2.5 years from diagnosis, with 23% having the MDC as their first visit. 40% had prior resection of primary, 25% were on somatostatin analogues (SSAs) previously and 9% of patients had received prior liver directed therapy (LDT). A significant proportion of patients had change in diagnosis post MDC evaluation: change in site (7%), stage of disease (7%), tumor type (3.5%) and grade (0.1%). A change in management was recommended in 50% of patients, with SSAs recommended in 43.8%, surgery in 25.4% and LDT in 17.5% of the patients. Conclusions: The use of a dedicated MDC to manage NETs had a substantial impact in change in management in a significant percentage of patients evaluated. MDC care for patients diagnosed with NET is recommended for optimal management.
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Aguilar-Saavedra, J. A. "Erratum to: “Pair production of heavy Q=2/3 singlets at LHC” [Phys. Lett. B 625 (2005) 234]." Physics Letters B 633, no. 6 (February 2006): 792–93. http://dx.doi.org/10.1016/j.physletb.2005.12.013.
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Qian, Li Min, Jie Zhou, Chu Zheng, Di Chen, Bi Shen, Yong Kun Liu, Li Xiao Wang, and Yan Hua Tong. "Comparative Photocatalytic Properties of Cu2O from Octahedron to Sphere Structures." Key Engineering Materials 609-610 (April 2014): 45–50. http://dx.doi.org/10.4028/www.scientific.net/kem.609-610.45.
Анотація:
Cu2O, a p-type semiconductor, has broad potential applications, especially as a visible-light photocatalyst. This paper presents a simple water-bath reflux to prepare Cu2O micro/nanoparticles. The morphology evolution from intact octahedrons to surface-pitted spheres was obtained by adjusting reducing agent and additive. Reflectance spectra show similar photo-absorption intensity and the same range from 250 nm to 650 nm. However, they perform different photocatalytic activity. Intact octahedron has the best photodegradation ability and next is vertex-and edge-damaged octahedron, the lowest for vertex-free polyhedrons and surface-pitted spheres. The enhanced photocatalytic activity for intact octahedrons should to be attributed to its surface characteristics of high index. Our study not only provides a simple method for controllable preparation of Cu2O micro/nanoparticles with different morphologies but also confirms the effect of morphologies on photocatalytic activity.
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Navari, Rudolph M., Cindy K. Nagy, Sujata Arora, Daniel Powers, and Rebecca Anne Clark-Snow. "Rolapitant for the prevention of nausea in patients receiving moderately or highly emetogenic chemotherapy." Journal of Clinical Oncology 34, no. 26_suppl (October 9, 2016): 224. http://dx.doi.org/10.1200/jco.2016.34.26_suppl.224.
Анотація:
224 Background: Nausea control remains an unmet need for patients receiving moderately or highly emetogenic chemotherapy (MEC, HEC). The objective of this analysis was to determine the effect of the neurokinin-1 (NK-1) receptor antagonist rolapitant (VARUBI) on the prevention of nausea in patients receiving either MEC or HEC. Methods: Post hoc analyses of nausea from three randomized, double-blind, active-controlled, phase 3 clinical trials were performed for carboplatin-based MEC (n = 401), non-carboplatin-based MEC (n = 228), total MEC (n = 629), anthracycline/cyclophosphamide (AC)-based chemotherapy (n = 703), and cisplatin-based HEC (n = 1070). Patients were randomized 1:1 to oral rolapitant 180 mg or placebo ~1–2 h before chemotherapy. All patients received active control: granisetron 2 mg oral or 10 mcg/kg IV and oral dexamethasone 20 mg. Granisetron was continued on days 2 and 3 for patients receiving MEC or AC-based therapy and dexamethasone 8 mg twice daily on days 2–4 for patients receiving HEC. Patients self-assessed nausea on days 1–6 using a 100-mm visual analog scale (VAS). Percentage of patients with no nausea (NN; maximum VAS < 5 mm) or no significant nausea (NSN; maximum VAS < 25 mm) was determined for overall, delayed, and acute phases of CINV in cycle 1. Results: Rates of NN in the carboplatin-based MEC and total MEC subgroups were significantly higher (P < 0.05) with rolapitant than active control in the delayed and overall phases. In the cisplatin-based HEC subgroup, rates of NN and NSN were significantly higher (P < 0.05) with rolapitant than active control in the delayed, acute, and overall phases. Conclusions: Rolapitant prevents nausea during all CINV phases in patients receiving cisplatin-based HEC, and during the delayed and overall phases in patients receiving carboplatin-based MEC. Clinical trial information: NCT01500226, NCT01499849, NCT01500213.
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Fotiadis, Nicos, Katja N. De Paepe, Lawrence Bonne, Nasir Khan, Angela Riddell, Nicholas Turner, Naureen Starling, et al. "Comparison of a coaxial versus non-coaxial liver biopsy technique in an oncological setting: diagnostic yield, complications and seeding risk." European Radiology 30, no. 12 (July 14, 2020): 6702–8. http://dx.doi.org/10.1007/s00330-020-07038-7.
Анотація:
Abstract Objectives Percutaneous liver biopsy (PLB) poses specific challenges in oncological patients such as bleeding and tumour seeding. This study’s aim was to compare a coaxial (C-PLB) and non-coaxial (NC-PLB) biopsy technique in terms of diagnostic yield, safety and seeding risk of image-guided PLB techniques in an oncological setting. Methods Local research committee approval was obtained for this single-site retrospective study. Patients who underwent a PLB between November 2011 and December 2017 were consecutively included. Medical records were reviewed to determine diagnostic yield and complications. Follow-up imaging was re-reviewed for seeding, defined as visible tumour deposits along the PLB track. Mann-Whitney U and chi-squared tests were performed to investigate differences between biopsy techniques in sample number, complications and seeding rate. Results In total, 741 patients (62 ± 13 years, 378 women) underwent 932 PLB (C-PLB 72.9% (679/932); NC-PLB 27.1% (253/932)). More tissue cores (p < 0.001) were obtained with C-PLB (median 4 cores; range 1–12) compared with NC-PLB (2 cores; range 1–4) and diagnostic yield was similar for both techniques (C-PLB 92.6% (629/679); NC-PLB 92.5% (234/253); p = 0.940). Complication rate (9.3%; 87/932) using C-PLB (8.2% (56/679)) was lower compared with NC-PLB (12.3% (31/253); p = 0.024). Major complications were uncommon (C-PLB 2.7% (18/679); NC-PLB 2.8% (7/253)); bleeding developed in 1.2% (11/932; C-PLB 1.2% (8/679); NC-PLB 1.2% (3/253)). Seeding was a rare event, occurring significantly less in C-PLB cases (C-PLB 1.3% (7/544); NC-PLB 3.1% (6/197); p = 0.021). Conclusions C-PLB allows for high diagnostic tissue yield with a lower complication and seeding rate than a NC-PLB and should be the preferred method in an oncological setting. Key Points • A coaxial percutaneous liver biopsy achieves a significant higher number of cores and fewer complications than a non-coaxial biopsy technique. • The risk of tumour seeding is very low and is significantly lower using the coaxial biopsy technique. • In this study, a larger number of cores (median = 4) could be safely acquired using the coaxial technique, providing sufficient material for advanced molecular analysis.
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Alleyne, C. M., I. D. Frantz, and J. J. Fredberg. "Preferential axial flow during high-frequency oscillations: effects of gas density." Journal of Applied Physiology 66, no. 2 (February 1, 1989): 542–47. http://dx.doi.org/10.1152/jappl.1989.66.2.542.
Анотація:
Allen et al. (J. Clin. Invest. 76: 620–629, 1985) reported that regional phasic lung distension during high-frequency oscillations (HFO) is substantially and systemically heterogeneous when both frequency (f) and tidal volume (VT) are large. They hypothesized that this phenomenon was attributable to central airway geometry and preferential axial flow induced therein by the momentum flux of the inspiratory gas stream. According to that hypothesis, the observed distribution of phasic lung distension would depend on the ratio VT/VD* (where VD* is an index of anatomic dead space), independent of gas density (rho), when f is scaled in proportion to lung resonant frequency, fo. To test this hypothesis, we used the methods of Allen et al. (ibid.) to study six excised dog lungs during HFO (f = 2–32 Hz; VT = 5–80 ml) using gases of different densities. Alveolar pressure excursions (PA) were measured as rho spanned a 12-fold range using He, air, and SF6. The apex-to-base and right-to-left ratios of PA were used as indexes of regional heterogeneity of phasic lung distension. For each gas at low f, distension of the lung base was favored slightly independent of VT, but at higher f distension of the lung apex was favored when VT was small, whereas distension of the lung base was favored when VT was large. In addition, we observed substantial right-to-left differences in apical lobes during oscillation at high f not seen before.(ABSTRACT TRUNCATED AT 250 WORDS)
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Aydin, Serap, Nafiz Arica, Emrah Ergul, and Oğuz Tan. "Classification of Obsessive Compulsive Disorder by EEG Complexity and Hemispheric Dependency Measurements." International Journal of Neural Systems 25, no. 03 (April 8, 2015): 1550010. http://dx.doi.org/10.1142/s0129065715500100.
Анотація:
In the present study, both single channel electroencephalography (EEG) complexity and two channel interhemispheric dependency measurements have newly been examined for classification of patients with obsessive–compulsive disorder (OCD) and controls by using support vector machine classifiers. Three embedding entropy measurements (approximate entropy, sample entropy, permutation entropy (PermEn)) are used to estimate single channel EEG complexity for 19-channel eyes closed cortical measurements. Mean coherence and mutual information are examined to measure the level of interhemispheric dependency in frequency and statistical domain, respectively for eight distinct electrode pairs placed on the scalp with respect to the international 10–20 electrode placement system. All methods are applied to short EEG segments of 2 s. The classification performance is measured 20 times with different 2-fold cross-validation data for both single channel complexity features (19 features) and interhemispheric dependency features (eight features). The highest classification accuracy of 85 ±5.2% is provided by PermEn at prefrontal regions of the brain. Even if the classification success do not provided by other methods as high as PermEn, the clear differences between patients and controls at prefrontal regions can also be obtained by using other methods except coherence. In conclusion, OCD, defined as illness of orbitofronto-striatal structures [Beucke et al., JAMA Psychiatry 70 (2013) 619–629; Cavedini et al., Psychiatry Res. 78 (1998) 21–28; Menzies et al., Neurosci. Biobehav. Rev. 32(3) (2008) 525–549], is caused by functional abnormalities in the pre-frontal regions. Particularly, patients are characterized by lower EEG complexity at both pre-frontal regions and right fronto-temporal locations. Our results are compatible with imaging studies that define OCD as a sub group of anxiety disorders exhibited a decreased complexity (such as anorexia nervosa [Toth et al., Int. J. Psychophysiol. 51(3) (2004) 253–260] and panic disorder [Bob et al., Physiol. Res. 55 (2006) S113–S119]).
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Huuskonen, Arto, Maiju Pesonen, and Maarit Hyrkäs. "Liharotuisten sonnien ja hiehojen kasvu- ja teurasominaisuudet." Suomen Maataloustieteellisen Seuran Tiedote, no. 28 (January 31, 2012): 1–7. http://dx.doi.org/10.33354/smst.75461.
Анотація:
Tutkimuksella haluttiin selvittää liharotuisten nautojen kasvu- ja teurasominaisuuksia. Tutkimusaineistona oli teurastamoilta saatu naudan ruhojen teurasaineisto, johon yhdistettiin ProAgria Maatalouden Laskentakeskuksen kautta saadut rotutiedot. Teurastamoaineistoa oli käytössä HK Agri Oy:ltä ja Snellman Lihanjalostus Oy:ltä vuodesta 2007 lähtien, A-Tuottajat Oy:ltä vuodesta 2008 lähtien ja Saarioinen Lihanjalostus Oy:ltä vuodesta 2010 lähtien. Hiehojen osalta alle 300 ja yli 550 vrk:n ikäiset eläimet jätettiin datasta pois. Vastaavasti sonnien osalta alle 365 ja yli 660 vrk:n ikäiset eläimet jätettiin datasta pois. Tutkimuksessa vertailtavia rotuja olivat aberdeen angus (ab), hereford (hf), li-mousin (li), charolais (ch), simmental (si) ja blonde d’Aquitaine (ba). Eläimen katsottiin edustavan kyseistä rotua, jos sen molemmat vanhemmat olivat ProAgria Maatalouden Laskentakeskuksen aineis-tossa luokiteltu ao. rodun edustajiksi. Näiden rajausten jälkeen tutkimusaineisto sisälsi 21 643 teurastettua liharotuista sonnia ja 8 743 liharotuista teurashiehoa. Roduittain ja sukupuolittain lopullinen aineisto muodostui seuraavasti: ab 4 068 sonnia, 1 692 hiehoa; hf 6 323 sonnia, 2 385 hiehoa; li 4 335 sonnia, 1 951 hiehoa; ch 4 421 sonnia, 1 794 hiehoa; si 2 152 sonnia, 774 hiehoa; ba 344 sonnia, 147 hiehoa. Sonnien kasvatusaika (vrk) ja teuraspaino (kg) muodostuivat roduittain seuraaviksi: ab (571 vrk, 368 kg), hf (572 vrk, 368 kg), li (571 vrk, 391 kg), ch (552 vrk, 413 kg), si (565 vrk, 402 kg) ja ba (570 vrk, 393 kg). Teuraspainojen osalta ainoastaan ab- ja hf-rodun sonnit sekä li- ja ba-sonnit eivät eronneet keskenään tilastollisesti merkitsevästi toisistaan. Kaikkien muiden rotujen välillä ero teuraspainossa oli merkitsevä (p<0.001). Sonnien nettokasvu (g/pv), lihakkuusluokka (EUROP) ja rasvaisuusluokka (EUROP) olivat roduittain seuraavat: ab (619 g/pv, R-, 3,3), hf (618 g/pv, R-, 3,2), li (660 g/pv, U-, 2,2), ch (724 g/pv, R+, 2,2), si (686 g/pv, R, 2,3) ja ba (663 g/pv, U-, 1,8). Nettokasvuissa ab ja hf-rodun sonnit sekä li- ja ba-sonnit eivät eronneet keskenään tilastollisesti merkitsevästi toisistaan, mutta kaikkien muiden rotujen välillä ero oli merkitsevä (p<0.001). Ruhojen lihakkuudessa ei ollut tilastollista merkitsevyyttä ab- ja hf-rotujen välillä; kaikki muut erot olivat tilastollisesti merkitseviä. Ruhojen rasvaisuudessa kaikki rodut erosivat toisistaan tilastollisesti merkitsevästi. Hiehojen keskimääräinen kasvatusaika oli 462 vrk. Teuraspaino (kg), nettokasvu (g/pv), lihakkuusluokka (EUROP) ja rasvaisuusluokka (EUROP) olivat roduittain seuraavat: ab (233 kg, 478 g/pv, O, 3,9), hf (252 kg, 468 g/pv, O, 3,9), li (250 kg, 504 g/pv, R-, 2,9), ch (255 kg, 538 g/pv, R-, 2,9), si (244 kg, 510 g/pv, O+, 3,0) ja ba (252 kg, 500 g/pv, R, 2,3). Teuraspainojen osalta ab- ja hf-rodun hiehot, ba- ja ch-hiehot sekä li- ja ba-hiehot eivät eronneet keskenään tilastollisesti merkitsevästi toi-sistaan, mutta muiden rotujen välillä ero teuraspainossa oli merkitsevä (p<0.001). Nettokasvuerot ba-, li- ja si-rotuisten hiehojen välillä eivät olleet merkitseviä; kaikki muut nettokasvuerot olivat tilastolli-sesti merkitseviä (p<0.001). Ruhojen lihakkuudessa kaikki rodut erosivat toisistaan tilastollisesti merkitsevästi (p<0.001). Ruhojen rasvaisuudessa ei ollut tilastollista merkitsevyyttä ab- ja hf-rotujen eikä ch- ja li-rotujen välillä; kaikki muut erot olivat tilastollisesti merkitseviä (p<0.001).
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Zalov, A. Z., K. O. İsgenderova, and Z. G. Askerova. "SPECTROPHOTOMETRIC RESEARCH INTO INTERACTION NICKEL (II) WITH 1- (2- PYRIDYLAZO) -2- HYDROXY -4-MERCAPTOFENOL AND AMINOPHENOLS." Chemical Problems 19, no. 3 (2021): 150–59. http://dx.doi.org/10.32737/2221-8688-2021-3-150-159.
Анотація:
The complexation reaction of nickel with 1-(2-pyridylazo)-2- hydroxy-4-mercaptophenol (PAGMP) in the presence of aminophenols (AP) was studied by spectrophotometric methods. Out of aminophenols there were used 2-(N,N-dimethylaminomethyl)-4-methylphenol and 2-(N, N-dimethylaminomethyl)-4- chlorophenol. We revealed optimum conditions for formation and extraction of differently ligand compounds and determined proportions of components in the complexes. It found that the complexes were formed in a weakly acidic environment (pH 3.5-6.5). The maximum in the light absorption spectrum is observed at λ=620-650 nm. The molar coefficient of light absorption is ε=(2.3-2.5)×104 . The optimal condition for the formation and extraction of these compounds is the concentration (1.2-1.5)×10-3 M PAGMP and (2.4- 2.6)×10-3 M AP. The maximum optical density is obtained within 15 minutes. Nickel МLC extracts with PAGMP and AF are subject to Beer's law at concentrations of 0.5–18 μg/ml. Proceeding from the results obtained, the photometric methods for the determination of nickel in water and soil were developed.
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Sheridan, Kathleen R., Rima Abdel-Massih, Nupur Gupta, and John Mellors. "627. Tele-OPAT Outcomes at Two Community Hospitals." Open Forum Infectious Diseases 7, Supplement_1 (October 1, 2020): S373—S374. http://dx.doi.org/10.1093/ofid/ofaa439.821.
Анотація:
Abstract Background Outpatient parenteral antimicrobial therapy (OPAT) is well-established for the care of patients requiring IV antibiotics after hospital discharge but little is known about the effectiveness of OPAT delivered through telemedicine.1-3 We therefore investigated outcomes from telemedicine OPAT services (Tele-OPAT) at two community hospitals. Methods Data was collected from two community hospitals in the UPMC system for which both inpatient and outpatient telemedicine ID services (Tele-ID), including Tele-OPAT services, are provided. Tele-ID services at Site 1 (171 beds) began in January 2014 and at Site 2 (133 beds) in January 2018. All patients had inpatient Tele-ID consults via live audio-video (AV) visits or EHR review. After discharge, patients were managed by a Tele-OPAT team consisting of an ID pharmacist, RN and ID physician. Live AV Tele-OPAT outpatient follow-up visits were conducted with the assistance of a tele-presenter at 2 clinic sites. Results A total of 489 unique patients with 536 encounters were evaluated. Site 1 accounted for 284 patients, Site 2 had 252. Demographics are listed in Table 1. 47% of the patients were male with an average age of 65. 51% of the patients were diabetic. Half of the patients were discharged to home. Bacteremia (24.4%) and osteomyelitis (23.3%) were the most frequent diagnoses. Vancomycin was the most commonly used antibiotic (25.6%). Tele-ID Clinic follow up rates varied by year and site between 19 to 26.6% (Figure 1). The choice of follow-up was determined by the primary inpatient physician. 30 Day Readmission Rates were lower for patients that were seen by the Tele-OPAT service (combined rate of 7.4%) vs. no follow up (62%) vs. PCP follow up (22%) vs. follow up with another MD (12.8%) (Figure 2a). Most patients seen by Tele-OPAT were readmitted for reasons not related to their initial infection or their antibiotic course (Figure 2b). Table 1. Patient Demographics Figure 1. Clinic Follow Up Rates Figure 2. Readmission Rates & Reasons for Readmission Conclusion Patients discharged on IV antibiotics who were managed via a Tele-OPAT service in an outpatient clinic had lower readmission rates than those who were seen by non-ID physicians or who had no outpatient follow-up. Tele-OPAT is an important option for patients residing in rural areas who are discharged on parenteral antibiotics. Disclosures Rima Abdel-Massih, MD, Infectious Disease Connect (Shareholder, Other Financial or Material Support, Chief Medical Officer) John Mellors, MD, Abound Bio (Shareholder)Accelevir Diagnostics (Consultant)Co-Crystal Pharmaceuticals (Shareholder)Gilead (Consultant, Grant/Research Support)Merck (Consultant)
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Zghama, A. O. "THE LEGAL INTEREST RATE AND INFLATIONARY LOSSES IN THE ECONOMIC RELATIONS: PRACTICE OF APPLICATION OF THE ARTICLE 625 OF THE CIVIL CODE OF UKRAINE." Juridical scientific and electronic journal, no. 2 (2020): 148–51. http://dx.doi.org/10.32782/2524-0374/2020-2/38.
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Alves, Sergio Agusto Oliveira, Oriel Filgueira de Lemos, Benedito Gomes dos Santos Filho, and André Luís Lopes da Silva. "In vitro protocol optimization for development of interspecific hybrids of oil palm (Elaeis oleifera (H.B.K) Cortés x Elaeis guineensis Jacq.)." Journal of Biotechnology and Biodiversity 2, no. 3 (August 8, 2011): 1–6. http://dx.doi.org/10.20873/jbb.uft.cemaf.v2n3.alves.
Анотація:
O dendezeiro (Elaeis guineensis) é a maior fonte de óleo vegetal no mundo. Porém, a doença do amarelecimento fatal está dizimando plantações no estado do Pará, Brasil. Para superar esse problema, híbridos interespecíficos de Elaeis oleifera x Elaeis guineensis são uma alternativa viável. Contudo alguns protocolos para o resgate in vitro desses embriões já foram estabelecidos, porém é necessário otimizá-los. O objetivo dessa pesquisa foi otimizar o protocolo in vitro para o cultivo de embriões interespecíficos de (Elaeis oleifera x Elaeis guineensis). A desinfestação das sementes foi realizada com 1 ou 2% de NaOCl por 20 ou 40 minutos. Embriões foram germinados in vitro na presença de 0; 0,1; 0,2 e 0,25% de carvão ativado e embriões foram cultivados na presença do ácido 2,4-diclorofenoxiacético (2,4–D) nas concentrações de 375, 500 e 625 μM para a indução de calos. A adição de 2,5% de carvão ativado é necessária para reduzir a oxidação fenólica dos embriões. A desinfestação das sementes pode ser realizada com 1% de NaOCl por 20 minutos. Diferentes variedades possuem diferentes concentrações ideais de 2,4–D para a indução de calos. As melhores concentrações de 2,4–D foram 375 e 625 μM para as variedades SJ-167 e SJ-165, respectivamente.
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Oliveira, Adriano Carvalho de, Carlos Júnior Silva de Souza, Johrdy Amilton da Costa Braga, Hércules Lázaro Morais Campos, Thiago Santos da Silva, and Thiago dos Santos Maciel. "Parâmetros usados na eletrofototerapia para a cicatrização de feridas: Uma revisão de escopo." Research, Society and Development 10, no. 6 (June 6, 2021): e45910616003. http://dx.doi.org/10.33448/rsd-v10i6.16003.
Анотація:
Objetivo: Apontar parâmetros utilizados para a cicatrização de feridas através de modalidades eletrofototerapêuticas em pacientes com úlceras por pressão e diabéticas. Métodos: Buscou-se artigos nas bases de dados: PubMed, BVS, SciELO e PEDro, publicadas entre 2010 e maio de 2020. Dois autores analisaram de forma independente os critérios de elegibilidade através da Escala PEDro. Resultados: Os estudos incluídos apontam que os recursos eletrofototerapêuticos podem ser eficazes no tratamento das úlceras por pressão e diabéticas e que esses recursos aplicados em conjunto com a intervenção convencional otimizam a melhora do paciente. Conclusões: Verificou-se uma grande heterogeneidade nos parâmetros analisados, sendo os mais eficazes a Luz de espectro, com 400 à 800 nm, 0,18 W/cm², 4 minutos, 2 aplicações por dia, durante 12 semanas. O LED, com 625, 660, 850 nm, 2,4 J/cm2, 50%, 5 minutos, 3 aplicações por semana, durante 8 semanas. A LLLT, com 685 nm, 0,05 W/cm², 10 J/cm2, 3 minutos, 6 aplicações por semana, com duração de 2 à 20 semanas. E a CAV, com 100 pps, 0,24 ou 0,25 A, 154 µs, 100 V, 250 ou 360 µC/s, 50 minutos, 5 aplicações por semana, com duração de 6 ou 8 semanas.
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Poon, Darren M. C., Jing Yuan, Bin Yang, Oi-Lei Wong, Sin-Ting Chiu, George Chiu, Kin-Yin Cheung, Siu-Ki Yu, and Raymond W. H. Yung. "A Prospective Study of Stereotactic Body Radiotherapy (SBRT) with Concomitant Whole-Pelvic Radiotherapy (WPRT) for High-Risk Localized Prostate Cancer Patients Using 1.5 Tesla Magnetic Resonance Guidance: The Preliminary Clinical Outcome." Cancers 14, no. 14 (July 18, 2022): 3484. http://dx.doi.org/10.3390/cancers14143484.
Анотація:
Background: Conventionally fractionated whole-pelvic nodal radiotherapy (WPRT) improves clinical outcome compared to prostate-only RT in high-risk prostate cancer (HR-PC). MR-guided stereotactic body radiotherapy (MRgSBRT) with concomitant WPRT represents a novel radiotherapy (RT) paradigm for HR-PC, potentially improving online image guidance and clinical outcomes. This study aims to report the preliminary clinical experiences and treatment outcome of 1.5 Tesla adaptive MRgSBRT with concomitant WPRT in HR-PC patients. Materials and methods: Forty-two consecutive HR-PC patients (72.5 ± 6.8 years) were prospectively enrolled, treated by online adaptive MRgSBRT (8 Gy(prostate)/5 Gy(WPRT) × 5 fractions) combined with androgen deprivation therapy (ADT) and followed up (median: 251 days, range: 20–609 days). Clinical outcomes were measured by gastrointestinal (GI) and genitourinary (GU) toxicities according to the Common Terminology Criteria for Adverse Events (CTCAE) Scale v. 5.0, patient-reported quality of life (QoL) with EPIC (Expanded Prostate Cancer Index Composite) questionnaire, and prostate-specific antigen (PSA) responses. Results: All MRgSBRT fractions achieved planning objectives and dose specifications of the targets and organs at risk, and they were successfully delivered. The maximum cumulative acute GI/GU grade 1 and 2 toxicity rates were 19.0%/81.0% and 2.4%/7.1%, respectively. The subacute (>30 days) GI/GU grade 1 and 2 toxicity rates were 21.4%/64.3% and 2.4%/2.4%, respectively. No grade 3 toxicities were reported. QoL showed insignificant changes in urinary, bowel, sexual, and hormonal domain scores during the follow-up period. All patients had early post-MRgSBRT biochemical responses, while biochemical recurrence (PSA nadir + 2 ng/mL) occurred in one patient at month 18. Conclusions: To our knowledge, this is the first prospective study that showed the clinical outcomes of MRgSBRT with concomitant WPRT in HR-PC patients. The early results suggested favorable treatment-related toxicities and encouraging patient-reported QoLs, but long-term follow-up is needed to confirm our early results.
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Zhong, Yu Rong, Man Zhao, and Bao Long Xu. "Synthesis and Luminescent Properties of Eu3+ Doped Lu2O3 Powders Using Micro-Emulsion." Key Engineering Materials 609-610 (April 2014): 346–50. http://dx.doi.org/10.4028/www.scientific.net/kem.609-610.346.
Анотація:
Europium-doped lutetium (Lu2O3:Eu3+ ) powders were prepared by micro-emulsion method. A small amount of an aqueous solution of Lu(NO3)3, Eu(NO3)3 and aqueous ammonia was slowly dropped into the water-in-oil micro-emulsion system (water / cetyl trimethyl ammonium bromide (CTAB) / n-butyl alcohol and cyclohexane) under vigorous stirring at 80 °C. The precipitates were obtained by Ostwald’s ripening at 250 °C for 6 h, which were then heated at 400 °C, 600 °C and 800 °C. The SEM morphology showed that the powders were rods of about few hundred nanometers in length and 40 nm in diameter. The spectrograms of X-ray diffraction (XRD) demonstrated that the Lu2O3:Eu3+ crystallinity was enhanced with the increasing of temperature. The photoluminescence results revealed that the intense emission bands centered at 612 nm. This method provides a new way to obtain different morphology and luminescent properties of Lu2O3:Eu3+ powder.
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Felix, Joel, Steven A. Fennimore, and John S. Rachuy. "Response of Alfalfa, Green Onion, Dry Bulb Onion, Sugar Beet, Head Lettuce, and Carrot to Imazosulfuron Soil Residues 2 Years after Application." Weed Technology 26, no. 4 (December 2012): 769–76. http://dx.doi.org/10.1614/wt-d-12-00011.1.
Анотація:
Field studies were conducted from 2009 to 2011 in Oregon and from 2006 to 2008 in California to evaluate the response of various crops to imazosulfuron soil residues 91 to 731 d after application (DAA). Imazosulfuron rates applied in Oregon were 224 or 450 g ai ha−1PRE, sequential 224 g ha−1PRE and POST, or 450 g ha−1as a tank mixture with PRE appliedS-metolachlor at 1,060 g ai ha−1followed by 224 g ha−1POST to potato. Imazosulfuron was applied on bare ground PRE at 224, 336, and 450 g ha−1and applied sequentially at 450 g ha−1in California. Sugar beet planted 91 to 364 and 458 to 731 DAA were injured 83 to 94% and 54 to 78% among imazosulfuron rates and application timing in 2007 and 2008, respectively. Alfalfa planted 701 DAA at rates greater than 224 g ha−1was injured, and the forage yield was reduced. Onion, spinach, carrot, and broccoli were also injured by imazosulfuron residues when planted 91 to 731 DAA, regardless of the rate or interval before planting. Imazosulfuron applied at 224 to 450 g ha−1458 to 731 d before planting head lettuce resulted in moderate injury that did not reduce fresh-weight yield. The results indicated that imazosulfuron residues in the soil have the potential to injure many rotational specialty crops for 2 yr or more in soils with pH > 6.9.
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Popkova, Tereza, Ludek Pour, Ivan Spicka, Jakub Radocha, Alexandra Jungova, Jiri Minarik, Tomas Jelinek, et al. "Survival Analysis of Newly Diagnosed Transplant-Eligible Multiple Myeloma Patients in Czech Republic." Blood 138, Supplement 1 (November 5, 2021): 4894. http://dx.doi.org/10.1182/blood-2021-153978.
Анотація:
Abstract Introduction: Although highly effective agents and novel therapeutic strategies are being developed, high-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) has not been overcome in the first-line treatment for fit patients (pts) with multiple myeloma. The objective of this work is to retrospectively analyze the use of this procedure in newly diagnosed Czech patients. Methods: Data were derived using the Czech Myeloma Group Registry of Monoclonal Gammopathies. By February 2 nd 2021, a total of 2154 newly diagnosed multiple myeloma patients who underwent HDT/ASCT were identified. Results: At the time of multiple myeloma diagnosis, the median age was 59 years; 24%/56%/14%/5%/1% pts were ECOG 0/1/2/3/4; 44%/32%/24% pts were ISS stage I/II/III; 14.5%/17.5%/68% and 84%/16% pts were Durie-Salmon stage I/II/III and subclassification A/B, respectively. The combinations of agents used in the induction regimen were proteasome inhibitor (PI), immunomodulatory drug (IMiD) and glucocorticoid (GC) in 28.5% (613/2154) pts; PI, GC and chemotherapy (CHT) in 24.8% (534/2154) pts; GC and CHT in 22,5% and IMiD, GC and CHT in 16.1% (346/2154). Other combination of drugs was used in 8.2% (177/2154) pts. It was registered that 3.7% (79/2154) induction regimens were switched to a different combination because of toxicity, patient's choice, poor peripheral venous access or other reasons. Single HDT/ASCT was performed in 77.3% (1665/2154) cases whereas tandem HDT/ASCT was given to 11.8% (254/2154) patients. In 10% (215/2154) cases, the transplantation technique was not specified. Nine percent (193/2154) patients were treated within a clinical study. The median progression free survival (mPFS) and the median overall survival (mOS) of the whole cohort was 28.9 and 92.1 months, respectively. Information about response to treatment before and after the high-dose therapy were available for 75.7% (1627/2154) and 92.2% (1987/2154) patients, respectively. Disease status at the time of HDT/ASCT was defined as stringent complete response (sCR) at 2.2% (36/1627), complete response (CR) at 11.9% (194/1627), very good partial response (VGPR) at 38.2% (621/1627), partial response (PR) at 40.9% (666/1627), minimal response (MR) at 3.6%, (58/1627), stable disease (SD) at 2.2% (36/1627), progressive disease (PD) at 1% (16/1627) patients. The overall response rate (ORR) on day 100 was 92.8% (sCR: 10.5% [209/1987], CR: 22.4% [446/1987], VGPR: 35% [696/1987], PR: 24.8% [493/1987], MR: 2.7% [54/1987], SD: 1.4% [27/1987], PD: 3.1% [62/1987]). We also performed a survival analysis of patients progressing up to 18 months after HDT/ASCT (n=1219) versus patients progressing in more than 18 months (n=935). The median OS was 41.5 versus 124.9 months, respectively. An analysis of the role of tandem HDT/ASCT in this real-world cohort will be presented at the conference. Conclusion: Globally as well as in the Czech Republic, HDT/ASCT is an important therapeutic approach in the first-line treatment of multiple myeloma. Our analysis of 2154 newly diagnosed transplant-eligible patients confirms high effectiveness - ORR of 92.8%, mPFS of 28.9 months, and long-term survival reaching mOS of 92.1 months. Disclosures Minarik: Amgen: Consultancy, Honoraria; BMS: Consultancy, Honoraria; Celgene: Consultancy, Honoraria; Janssen: Consultancy, Honoraria; Sanofi: Consultancy, Honoraria; Takeda: Consultancy, Honoraria.
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Bain, Nurul Husna As Saedah, Noorshida Mohd Ali, Yusnita Juahir, Norhayati Hashim, Illyas Md Isa, Azmi Mohamed, Azlan Kamari, and Bohari Mohd Yamin. "Synthesis, Spectroscopic, and Photophysical Studies of Phosphorescent Bis(2-(2,4-difluorophenyl)pyridine)Iridium(III) Complex Containing Derivative of 1<i>H</i>-1,2,4-Triazole Anchillary Ligand." Indonesian Journal of Chemistry 21, no. 6 (November 30, 2021): 1577. http://dx.doi.org/10.22146/ijc.66471.
Анотація:
A cationic complex of iridium(III), [Ir(2,4-F2ppy)2(F2bpyta)]PF6 utilizing 1,2,4-triazolepyridyl as an anchillary ligand modified with a 2,6-difluorobenzyl substituent was synthesized and characterized. The aromatic signals of pyridyltriazole and phenylpyridine proton were detected in the 1H-NMR spectrum between 10.00 and 7.00 ppm. Only one singlet peak was detected at 8.46 ppm H(8) shifted to the upfield, demonstrating that C5 was coordinated to the central iridium metal. The bands exhibited in the range of 1555–1431 cm–1 in the IR spectrum because of the C=C and C=N aromatic rings stretching pyridine, phenyl, and triazole vibrations. The UV-Vis absorption spectrum showed a slight and broad absorbance peak at lower energy at a lmax = 371 nm (e = 6129 M−1 cm−1) in the visible range due to 1MLCT and 3MLCT transitions. Blue emission was observed in the steady-state emission spectral of [Ir(2,4-F2ppy)2(F2bpyta)]PF6 and the other two previously synthesized iridium(III) complexes in CH2Cl2 solutions (air-equilibrated) at room temperature. The spectrum of luminescence for the [Ir(2,4-F2ppy)2(F2bpyta)]PF6 (lem = 461 nm) is blue-shifted when compared to the [Ir(2,4-F2ppy)2(hpyta)]PF6 (lem = 469 nm), but red-shifted when related to the [Ir(2,4-F2ppy)2(mbpyta)]PF6 (lem = 454 nm).
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CIARDI, MARCO. "MARIA LUISA BERTI, DUCCIO BIGAZZI (a cura di), Ricerche di storia in onore di Franco Della Peruta, 2 voll., Milano, Franco Angeli, 1996, 602 e 629 pp. (ISBN 88-204-9854-5 e 88-204-9853-7)." Nuncius 13, no. 1 (January 1, 1998): 366–68. http://dx.doi.org/10.1163/221058798x00477.
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Mingaleva, Z. A., and A. A. Gatayllina. "Perspectives of Creation Innovative Clusters in the Life Sciences." Izvestiya of Saratov University. New Series. Series Economics. Management. Law 13, no. 4(2) (2013): 629–33. http://dx.doi.org/10.18500/1994-2540-2013-13-4-2-629-633.