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Статті в журналах з теми "658.7.073:33:001.18 (043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Dombret, Hervé, Alexandra Coelho, Laurène Fenwarth, et al. "Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study." Blood 144, Supplement 1 (2024): 2424. https://doi.org/10.1182/blood-2024-207226.

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Introduction. AML treatment options have been recently enriched. New agents like gemtuzumab ozogamicin (GO), FLT3 or IDH inhibitors, or CPX-351 have been approved for some patient subsets. Less-intensive options, like the AZA-VEN combination, are used in older/unfit patients. However, while treatments and indications are standardized, their choice is not, depending on often-subjective factors. This makes observational studies so important to describe the real-life management and outcomes of AML patients. Methods. In 2022, the ALFA group initiated a 2-cohort (newly diagnosed, relapsed/refractor

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2

Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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3

Pérez, Ariadna, Monica Cabrero Calvo, Juan Montoro, et al. "Incidence, Clinical Risk Factors, and Biomarkers of SOS/VOD Following Allogeneic HSCT in Adults: A Real-Life Study By the Spanish Group of Hematopoietic Stem Cell Transplantation and Cell Therapy (GETH-TC)." Blood 144, Supplement 1 (2024): 4869. https://doi.org/10.1182/blood-2024-206887.

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Introduction Sinusoidal obstruction syndrome (SOS) or hepatic veno-occlusive disease (VOD) is a serious complication following hematopoietic stem cell transplantation (HSCT) with an overall incidence ranging from 5% to 15% and a highly variable mortality rate. Recently, the European Society for Blood and Marrow Transplantation (EBMT) updated the diagnostic criteria, severity assessments, and risk factor evaluations for SOS/VOD (Mohty M et al. 2023). The EASIX score, a biomarker of endothelial dysfunction, has been associated to the incidence of SOS/VOD, overall survival (OS), and non-relapse m

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4

Rivera Teran, V., D. Alpizar-Rodriguez, S. Sicsik, et al. "FRI0546 GENDER DIFFERENCES OF RHEUMATIC DISEASES IN MEXICAN POPULATION: DATA FROM THE MEXICAN BIOLOGICS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 874–75. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6091.

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Background:Most autoimmune diseases are more prevalent in women. Symptom severity, disease progression, response to therapy and overall survival differ between males and females with rheumatic diseases.Objectives:To identify the characteristics of autoimmune diseases presentation and treatment between male and female population using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican ongoing cohort that collects the information of patients using biologic and biosimilar drugs since 2016. For this study we included all patients enrolled in the regis

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5

Monteith, Bethany E., Esther Masih-Khan, Eshetu G. Atenafu, et al. "Patterns of Relapse and Progression in Multiple Myeloma Patients Treated with Conventional and Novel Agent-Based Therapy: A Single Centre Experience." Blood 126, no. 23 (2015): 5361. http://dx.doi.org/10.1182/blood.v126.23.5361.5361.

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Abstract Background The incorporation of novel agents (NA) for multiple myeloma (MM) has improved the response rates (RR), overall survival (OS), and progression free survival (PFS) when compared to conventional agents (CA). Unfortunately, relapse is inevitable and few studies focus on patterns of relapse, especially in non-transplant patients (pts). We aim to describe the different patterns of relapse in non-transplant MM pts and determine if any pre-treatment clinical or disease characteristics can predict the patterns relapse. We will evaluate whether NA treated pts have higher rates of agg

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6

Magnus, Dan, Santosh Bhatta, and Julie Mytton. "432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries." Emergency Medicine Journal 37, no. 12 (2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.

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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the fir

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7

Blapp, C., S. Yaghmaei, A. Ciurea, A. Scherer, M. Kuster, and K. Lauper. "POS0270 BURDEN OF COVID-19 IN PATIENTS WITH INFLAMMATORY RHEUMATIC DISEASES: INSIGHTS FROM A SWISS APP-BASED SURVEY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 373–74. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2533.

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BackgroundCOVID-19 comes with a significant medical risk for patients with inflammatory rheumatic diseases, with an increased risk of infection and severe outcomes[1]. The vulnerability of rheumatologic patients might also affect their quality of life[2], for example by keeping up protective measures (masking, restriction of social contacts, etc.) while the general Swiss public no longer does so.ObjectivesThe aim of this study was to better understand the health-related burden of COVID-19 among patients with inflammatory rheumatic diseases and to investigate factors contributing to a different

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8

Robin, Marie, Federica Giannotti, Eric Deconinck, et al. "Outcomes After Unrelated Cord Blood Transplantation For Adults With Primary Or Secondary Myelofibrosis: A Retrospective Study On Behalf Of Eurocord and Chronic Malignancy Working Party-EBMT." Blood 122, no. 21 (2013): 2156. http://dx.doi.org/10.1182/blood.v122.21.2156.2156.

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Abstract Background Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only curative option for patients (pts) with myelofibrosis (MF). Patients with MF transformed to Acute Myeloid Leukemia (AML) have a very short life expectancy without transplantation (< 4 months). Umbilical cord blood transplantation (UCBT) from unrelated donor is a valid alternative to conventional allogeneic HSCT for pts with hematologic malignancies who do not have an HLA matched donor. Delayed engraftment and graft failure are the limitations of this procedure and represent a major issue for

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9

Marquez, Félix Gibrant, Santiago Riviello-Goya, Angel Gabriel Vargas Ruiz, et al. "Low Rate of Thrombosis in Mexican Patients with COVID-19 Infection. a Benefit of Higher Doses Anticoagulants or a Sub Diagnosis?" Blood 136, Supplement 1 (2020): 29–30. http://dx.doi.org/10.1182/blood-2020-136240.

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Background: Patients with COVID-19 have an increased risk of thromboembolic disease, this has been partly attributed to an excessive inflammatory response that is associated with hypercoagulability; patients develop thrombotic complications with rates of 6.4% in non-critically ill and 15 to 31 % in critically ill patients. With this data some clinicians have incorporated thromboprophylaxis with higher dose heparin into the management of this patients, to date there´s no information of the effect of this intervention. Methods: We conducted a prospective cohort, including consecutive critical an

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10

Arumugam, Paritha, Fabrizia Urbinati, Chinavenmeni S. Velu, H. Leighton Grimes, and Punam Malik. "The 3′ End of the Chicken Hypersensitive Site-4 Insulator Has Properties Similar to the 5′ Insulator Core and Is Necessary in Conjunction with the Core for Full Insulator Activity." Blood 112, no. 11 (2008): 817. http://dx.doi.org/10.1182/blood.v112.11.817.817.

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Abstract Genetic correction of hematologic defects is currently impeded by inefficient vector technology. We find that vectors that insulate the correcting transgene from position effects and genotoxicity compromise viral titers. Here we present an improved vector system which utilizes a modified insulator element, without sacrificing viral titers. Specifically, our genetic and epigenetic analysis of the 1.2kb chicken β-globin hypersensitive site-4 (cHS4) insulator reveal heretofore unknown activities in regions of the chicken β-globin insulator element outside the canonical and well studied 2

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11

Borlenghi, Erika, Lorenzo Masina, Marco Frigeni, et al. "Venetoclax and Hypomethylating Agents Confirmed to be Standard Therapy in De Novo and ELN17 Not Adverse Acute Myeloid Leukemia Patients, Unfit for Chemotherapy According to SIE/Sies/GITMO Criteria. a Multicentric Real-Life Study on 379 Patients, By the Hematological Network Rete Ematologica Lombarda (REL)." Blood 144, Supplement 1 (2024): 2863. https://doi.org/10.1182/blood-2024-202530.

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Treatment of elderly acute myeloid leukemia (AML) is still challenging. In patients (pts) unfit for chemotherapy (CT) the best results are obtained by the association venetoclax (VEN) and hypomethylating agents (HMA) but, given its substantial toxicity compared to HMA alone, it is unclear whether in clinical practice it should be reserved to a proportion of relatively less “unfit” pts. Age, level of comorbidities and functional impairment, therapy benefits and risks, pts preferences, and AML features may influence the treatment choice. Within the Rete Ematologica Lombarda (REL), we conducted a

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12

Farheen, Jabeen, and Simeen Mansoor. "Anti-stress phytohormones impact on proteome profile of green gram (Vigna radiata) under salt toxicity." World Journal of Biology and Biotechnology 5, no. 2 (2020): 17. http://dx.doi.org/10.33865/wjb.005.02.0213.

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Green gram (Vigna radiata) is considered the chief legume in Pakistan. Thus, current study was conducted to examine the ameliorating effect of phytohormones pre-treatments under salt stress on proteome profile of green gram by sodium-dodecyl-sulphate-polyacrylamide gel electrophoresis (SDS-PAGE). The soluble green gram seedlings proteins were resolved on 4% stacking and 12% resolving gels. The SDS-PAGE resolved 24 polypeptide bands ranging from 200 to 17kDa. Among these, 12 out of 24 bands of proteins were essentials house-keeping or growth proteins of green grams. While, 120, 114.6, 51.8, 29.

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13

de Vries, Pauline L. M., Eric Verspyck, Estelle Morau, Monica Saucedo, and Catherine Deneux‐Tharaux. "Maternal mortality due to obstetric hemorrhage by surgical injury during cesarean section: A nationwide study." Acta Obstetricia et Gynecologica Scandinavica, July 18, 2024. http://dx.doi.org/10.1111/aogs.14917.

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AbstractIntroductionObstetric hemorrhage remains a largely preventable cause of maternal mortality globally. The contribution of uterine atony to hemorrhage‐related maternal mortality has decreased in France, while the contribution of other causes of obstetric hemorrhage such as surgical injury during cesarean has been reported to increase. However, little evidence exists regarding the risk factors and care processes of women who died from this cause of hemorrhage. Therefore, we aimed to describe the clinical profile, underlying mechanisms, and preventability factors among women who died from

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14

Maurizi, N., S. Day, E. Ashley, et al. "Long term outcome after septal reduction therapies in patients with hypertrophic cardiomyopathy: insights from the SHaRe registry." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.1852.

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Abstract Background Long term outcome after septal reduction therapies SRT in HCM patients is largely unresolved, since most available studies report post-operative results up to 1 year. Purpose To evaluate the long term outcome and its predictors in patients with HCM from the SHaRe Registry (Sarcomeric Human Cardiomyopathy Registry) Registry. Methods Data from 11 high-volume HCM specialty centers from the international SHaRe Registry were used to describe the natural history of patients with SRT. Patients were followed from SRT until last follow-up or meeting the composite outcome of heart fa

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15

Du, Mengxi, and Fang Fang Zhang. "Dietary Supplement Use Among Adult Cancer Survivors in the United States." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.168.6.

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BackgroundMany cancer patients initiated supplement use after cancer diagnosis and yet the effect of supplement use on survival has not been established. The trend of and factors associated with dietary supplement use in cancer survivors warrant further investigation.MethodsWe examined the trend of dietary supplemental use in 1,902 adult cancer survivors who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, and compared the frequency of supplement use in cancer survivors to that of 3,804 individuals with no history of cancer who were matched to th

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16

Mirmozaffari, Yasine, Ameer Ghodke, Rupali N. Shah, and Robert A. Buckmire. "Does Idiopathic Subglottic Stenosis Length and Location Change with Serial Endoscopic Interventions?" Laryngoscope, October 3, 2023. http://dx.doi.org/10.1002/lary.31080.

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Objectives/HypothesisThe aim was to assess changes in physical parameters of subglottic stenosis (SGS) following serial endoscopic surgical intervention. Demographics for included patients who underwent a second procedure with completed measurements diagnosed with idiopathic subglottic stenosis undergoing surgery (N = 52). Demographics Mean or # (% or SD) Age 55.1 (±15.1) Gender (Female) 50 (96.2) Race (White) 44 (84.6) BMI 29.9 (±6.8) Average # procedures (Range 1 to 5) 3.4 (±1.3) Surgeon (RAB) 33 (63.5) Comorbidities # Patients (%) Smoking (former or current) 3 (5.8) Heart disease 7 (13.5) P

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sprotocols. "Engineering of ultra-small diagnostic nanoprobes through oriented conjugation of single-domain antibodies and quantum dots." January 7, 2015. https://doi.org/10.5281/zenodo.13799.

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Authors: Alyona Sukhanova, Klervi Even-Desrumeaux, Patrick Chames, Daniel Baty, Mikhail Artemyev, Vladimir Oleinikov & Igor Nabiev ### Abstract Nanoparticle-based biodetection commonly employs monoclonal antibodies (mAbs) for targeting. Although several types of conjugates have been used for biomarker labeling, the large size of mAbs limits the number of ligands per nanoparticle, impedes their intratumoral distribution, and limits intracellular penetration. Furthermore, the conditions of mAb conjugation using conventional techniques provide nanoprobes with irregular orientation of mAbs on

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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sprotocols. "Reprogramming human amniotic fluid stem cells to functional pluripotency by manipulation of culture conditions." January 9, 2015. https://doi.org/10.5281/zenodo.13860.

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Authors: Dafni Moschidou & Pascale V Guillot ### Abstract Pluripotent stem cells have potential applications in regenerative medicine, disease modelling and drug screening. Induced pluripotent stem (iPS) cells have first been generated from fibroblasts using retroviral insertion of OCT4A, SOX2, c-MYC and KLF4. Since then, a number of methods have been developed to avoid the random integration of ectopic factors in the genome and the low efficiency of the process. Those include alternative integrating, non-integrating, excisable and DNA-free systems, but they all present challenges that pre

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sprotocols. "High Resolution Melting Analysis for fast and cheap polymorphism screening of marine populations." January 14, 2015. https://doi.org/10.5281/zenodo.13940.

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Authors: Anne-Leila Meistertzheim, Isabelle Calves, Sébastien Artigaud, Carolyn S. Friedman, Christine Paillard, Jean Laroche & Claude Ferec ### Abstract This protocol permits the mutation scanning of PCR products by high-resolution DNA melting analysis requiring the inclusion of a saturating intercalating dye in the PCR mix without labelled probe. During a scanning process, fluorescent melting curves of PCR amplicons are analyzed. Mutations modifying melting curve shapes, are allowed to be further characterized by sequencing because melting is not destructive. The method detects on small

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