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Статті в журналах з теми "711.64 (043.2)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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1

Whittall, Ian R., Mark G. Humphrey, and David C. R. Hockless. "Structural Systematics of Metal Acetylide Complexes: X-Ray Studies of Some 'Extended-Chain' Gold σ-Acetylide Complexes." Australian Journal of Chemistry 50, no. 10 (1997): 991. http://dx.doi.org/10.1071/c97049.

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The structures of Au(4-C≡CC6H4XYC6H4-4′-NO2)(PPh3) (XY = (E )-CH=CH (1), (Z)-CH=CH (2), C≡C (3), N=CH (4)) have been determined by single-crystal X-ray diffraction analyses, refining by full-matrix least-squares analysis. For (1), crystals are triclinic, space group P-1, with a8·847(1), b 17·870(4), c 19·705(3) Å, α116·25(1), β 93·33(1), γ 92·64(2)˚, Z 4, 6747 unique reflections (703 parameters), converging at R 0·025 and Rw 0·029. For (2), crystals are monoclinic, space group P 21/a, with a 10·718(6), b 19·398(5), c14·469(3) Å, β 108·96(2)˚, Z 4, 3295 unique reflections (352 parameters), conv

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2

Penner, Jeremy, Loice Achieng Ombajo, Davies Otieno, et al. "High rates of kidney impairment among older people (≥ 60 years) living with HIV on first-line antiretroviral therapy at screening for a clinical trial in Kenya." PLOS ONE 18, no. 6 (2023): e0285787. http://dx.doi.org/10.1371/journal.pone.0285787.

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Background There is a paucity of data on kidney impairment among older people living with HIV (PLWH). We evaluated kidney function among PLWH age ≥ 60 years on first-line antiretroviral (ARV) therapy during screening for a clinical trial in Kenya. Methods The bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) Elderly Study is an open-label, randomized, active-controlled, non-inferiority trial conducted at two sites in Kenya. Potential participants were screened for study entry if they were at least 60 years old, had been on ARVs for at least 24 weeks and had no history of treatment fail

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3

Farah, Arthur, Sabrina Hafemann Loz, Dieter Alisson Neumann, et al. "Fatores associados e desfechos adversos relacionados ao ganho de peso excessivo em uma Maternidade Pública do Sul do Brasil." STUDIES IN HEALTH SCIENCES 6, no. 1 (2025): e14510. https://doi.org/10.54022/shsv6n1-043.

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Objetivo: Avaliar os desfechos adversos perinatais relacionados ao ganho de peso excessivo (GPE) materno na gestação. Métodos: Trata-se de um estudo de corte transversal, realizado na Maternidade Darcy Vargas em Joinville-SC, no período de agosto a dezembro de 2020. Realizou-se uma entrevista a uma amostra composta de puérperas maiores de 18 anos. Dividiu-se as pacientes em 2 grupos, pacientes com e sem ganho de peso excessivo. Foram analisados os desfechos gestacionais adversos através do cálculo de razão de chance ajustado, onde utilizou-se o intervalo de confiança de 95%. Resultados: As pac

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4

Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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5

Robinson, F. E., T. A. Wautier, R. T. Hardin, J. L. Wilson, M. Newcombe, and R. I. McKay. "Effects of age at photostimulation on reproductive efficiency and carcass characteristics. 2. Egg-type hens." Canadian Journal of Animal Science 76, no. 3 (1996): 283–88. http://dx.doi.org/10.4141/cjas96-043.

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Increasing day length is the primary cue for the timing of sexual maturation in poultry. Typically, Single Comb White Leghorn (SCWL) pullets are reared under conditions of short days (8L:16D) until 18 wk of age. In this study, the effects of varying the age at photostimulation from 16, 18 or 20 wk of age were studied in terms of carcass composition at photostimulation and at sexual maturity, as well as reproductive performance.A flock of 1600 SCWL pullets (Shaver 288 strain) were housed in floor pens in light-tight facilities (8L:16D). All birds were provided with ad-libitum access to both fee

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6

Acharya, S. N., D. G. Stout, B. Brooke, and D. Thompson. "Cultivar and storage effects on germination and hard seed content of alfalfa." Canadian Journal of Plant Science 79, no. 2 (1999): 201–8. http://dx.doi.org/10.4141/p98-043.

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The impermeable coat of alfalfa (Medicago sativa L.) seed can reduce germination to an extent unacceptable for commercial use. The usual method of increasing germination of lots with high proportion of impermeable or hard seeds, mechanical scarification, can damage seeds. Experiments were conducted to determine the effect of cultivar, year of production and storage conditions on germination and hard seed content in alfalfa. Experiments with four Canadian cultivars indicated a significant effect of cultivar on seed weight, germination and hard seed content in freshly harvested seed. Year of pro

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7

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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8

Puah, Soo Huan, Nur Iffah Illani Mohamed Rasidi, Yi Jing Tan, Nur Syahiidah Mohamad Ikhiwan, Muhammad Faris Nazmi Mohammad Ibrahim, and Poh Shean Wong. "CLINICAL CONSEQUENCES OF INSULIN DEPRESCRIBING IN TYPE 2 DIABETES." Journal of the ASEAN Federation of Endocrine Societies 40, S1 (2025): 126–27. https://doi.org/10.15605/jafes.040.s1.215.

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INTRODUCTIONType 2 diabetes (T2D) is characterised by insulin resistance and progressive beta-cell dysfunction, leading to failure on oral glucose-lowering drugs (OGLDs). Insulin deprescribing requires individualisation, considering factors like residual beta-cell function, disease duration and insulin dosage. This study explores the characteristics and outcomes of patients with T2D who had insulin deprescribed at a local health clinic before hospitalisation. METHODOLOGYWe performed a retrospective medical records review involving adult patients with T2D admitted to Hospital Jempol from Septem

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9

Edwards, S. A., A. W. Armsby, and H. H. Spechter. "Effects of floor area allowance on performance of growing pigs kept on fully slatted floors." Animal Production 46, no. 3 (1988): 453–59. http://dx.doi.org/10.1017/s0003356100019061.

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ABSTRACTThe experiment compared four different space allowances for growing pigs housed on fully slatted floors. Space allowance (A m2) was defined in relation to live weight (M kg) of the pigs according to the equation A = kM0·67, using values for the constant (it) of 0·024, 0·027, 0·030 and 0·034. Six replicate pens of 12 pigs were housed on each treatment in a controlled environment building. Food was given ad libitum and from 34 kg until slaughter at 85 kg pigs were individually weighed each week and the pen size was adjusted according to the appropriate equation. Increasing space allowanc

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10

Gollins, Simon, Arthur Sun Myint, Brian Haylock, et al. "Preoperative Chemoradiotherapy Using Concurrent Capecitabine and Irinotecan in Magnetic Resonance Imaging–Defined Locally Advanced Rectal Cancer: Impact on Long-Term Clinical Outcomes." Journal of Clinical Oncology 29, no. 8 (2011): 1042–49. http://dx.doi.org/10.1200/jco.2010.29.7697.

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Purpose To assess long-term clinical outcomes of preoperative chemoradiotherapy of magnetic resonance imaging (MRI)–defined locally advanced rectal adenocarcinoma using concurrent irinotecan and capecitabine. Patients and Methods One hundred ten patients without distant metastases entered this phase II trial North West/North Wales Clinical Oncology Group (NWCOG) -2 after MRI demonstration of tumor threatening (≤ 2 mm) or involving mesorectal fascia. Pelvic radiotherapy was given to 45 Gy in 25 fractions over 5 weeks with concurrent oral capecitabine at 650 mg/m2 twice per day continuously days

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11

Effendy, John D. Kildea, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXVIII Synthesis and Structural Systematics of Some 1 : 3 Adducts of Silver(I) Compounds with Triphenylstibine, [(Ph3Sb)3AgX], X = Cl, I, SCN, NCS, CN, ONO2." Australian Journal of Chemistry 50, no. 6 (1997): 587. http://dx.doi.org/10.1071/c96035.

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The syntheses and room-temperature single-crystal X-ray structural characterization of 1 : 3 adducts formed between silver(I) (pseudo-) halides, AgX, and triphenylstibine, SbPh3, are described for X = Cl, I, SCN, NCS, CN, NO3 (1)-(6). The chloride, as its methanol solvate (1a), is isomorphous with the arsine analogue: triclinic, P-1, a 13·373(4), b 14·48(6), c 14·702(3) Å, α 83·49(3), β 87·76(2), γ 76·45(3)°; Z = 2, conventional R on F being 0·046 for No 5514 independent ‘observed’ reflections (I > 3σ(I )). A new form (1b) of the chloride has also been authenticated: monoclinic, P 21/c, a 1

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12

Anderton, Laurel K., and Michael J. Jenkins. "Cone entomofauna of whitebark pine and alpine larch (Pinaceae): potential impact of Leptoglossus occidentalis (Hemiptera: Coreidae) and a new record of Strobilomyia macalpinei (Diptera: Anthomyiidae)." Canadian Entomologist 133, no. 3 (2001): 399–406. http://dx.doi.org/10.4039/ent133399-3.

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AbstractLaboratory and field feeding tests with Leptoglossus occidentalis Heidemann demonstrated that both immature and mature seed bugs can use cones and foliage of whitebark pine, Pinus albicaulis Engelmann, as a food source for 1- to 2-week periods. Damage to unprotected whitebark pine cones by seed bugs ranged from 0.3 to 2.1% of seeds per cone. Total insect damage ranged from 0.4 to 7.1% of seeds per cone. A seed chalcid, Megastigmus Dalman. sp. (Hymenoptera: Torymidae), was documented for the first time on whitebark pine and was found in 4.7% of examined seeds at one site. The larch cone

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13

Doherty, Mark, Stephanie Moignard, Gonzalo Sapisochin, et al. "Baseline anemia in patients with biliary tract cancer (BTC) and its association with survival: A retrospective cohort study." Journal of Clinical Oncology 36, no. 4_suppl (2018): 426. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.426.

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426 Background: The prognostic significance of anemia in BTC is unknown, but is common and may be multifactorial; data regarding its causes are limited. This study interrogated a large institutional database to examine the effect of anemia on overall survival (OS) in BTC, and explore factors associated with anemia. Methods: This Princess Margaret Cancer Centre cohort study included patients with BTC with available baseline hemoglobin (Hb) (1987-2016). Anemia was defined as Hb < 132 mg/dL for men > 60 years, < 137mg/dL for men aged 20-59, and < 122mg/dL in women. Additional relevant

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14

Curtis, Neil F., Olga P. Gladkikh, and Mark M. Turnbull. "Copper(II) Compounds with Amine Imine Ligands; Structures of (2,4,6,9,11-Pentamethyl-5,8-diazadodeca-4,8-diene-2,11-diamine)copper(II) Perchlorate and (2,4-Dimethyl-5,8,11- triazatridec-4-ene-2,13-diamine)copper(II) Perchlorate." Australian Journal of Chemistry 51, no. 7 (1998): 631. http://dx.doi.org/10.1071/c97172.

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(2,4,6,9,11-Pentamethyl-5,8-diazadodeca-4,8-diene-2,11-diamine)copper(II) perchlorate, formed by reaction of (propane-1,2-diamine)copper(II) perchlorate with 4-amino-4-methylpentan-2-one, has the copper(II) ion in tetrahedrally twisted [±0·23(1) Å] square planar coordination by the tetradentate ligand, with a weak axial interaction with a perchlorate ion with Cu–O 2·64(1) Å [C15H32Cl2CuN4O8, Mr 530·89, monoclinic, space group P21/n, a 9·938(7), b 13·591(7), c 17·149(9) Å, β 106·65(5)°, Z 4, R1 0·066 for 1096 reflections]. 2,4-Dimethyl-5,8,11-triazatridec-4-ene-2,13-diamine)copper(II) perchlora

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15

Hershow, Ronald C., Walid F. Khayr, and Nina L. Smith. "A Comparison of Clinical Virulence of Nosocomially Acquired Methicillin-Resistant and Methicillin-Sensitiye Staphylococcus aureus Infections in a University Hospital." Infection Control & Hospital Epidemiology 13, no. 10 (1992): 587–93. http://dx.doi.org/10.1086/646433.

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AbstractObjectives:To compare the clinical virulence of nosocomially acquired methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S aureus (MSSA) infections in 1989.Design:A retrospective comparison of host factors, in-hospital exposures, sites of infections, and outcomes of patients with nosocomial MRSA and MSSA infections.Setting:University of Illinois Hospital, Chicago, Illinois.Participants:Forty-four adult patients with nosocomial S aureus infections.Results:The 22 MRSA-infected and 22 MSSA-infected persons were similar regarding mean age, gender, underlying disea

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16

Omoleye, Olasubomi J., Anna Woodard, Fangyuan Zhao, et al. "Abstract 1933: Independent evaluation and validation of mammography-based breast cancer risk models in a diverse patient cohort." Cancer Research 82, no. 12_Supplement (2022): 1933. http://dx.doi.org/10.1158/1538-7445.am2022-1933.

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Abstract Imaging-based machine learning models are promising tools for breast cancer risk prediction. Validating these models across diverse cohorts is necessary to establish performance and spur clinical implementation. We conducted an independent, external validation study of Mirai, a mammography-based deep learning model, using the Chicago Multiethnic Epidemiologic Cohort (ChiMEC), comprising 1671 exams from 704 cases and 4947 exams from 1437 cancer-free controls. We preprocessed images by extracting metadata from mammograms and excluded non-screening exams. Only exams with the four standar

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17

Debnath, Samir C. "A Scale-up System for Lowbush Blueberry Micropropagation Using a Bioreactor." HortScience 44, no. 7 (2009): 1962–66. http://dx.doi.org/10.21273/hortsci.44.7.1962.

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In an attempt to improve the micropropagation protocol for lowbush blueberry (Vaccinium angustifolium Ait.), a protocol using a bioreactor system combined with a semisolid gelled medium has been developed. Cultures of cultivar Fundy and two wild clones (‘NB1’ and ‘QB1’) were established in vitro on a gelled modified cranberry basal medium (BM) containing 5 μM zeatin or 10 μM N6-[2-isopentenyl]adenine. Multiple shoots were obtained within 8 weeks by transferring zeatin-induced shoots from the gelled BM to a bioreactor containing liquid BM with 1 to 4 μM zeatin. Genotypes differed significantly

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18

Noreña Gomez, Sara Isabel, Angie Carolina Morales Suárez, Ángela Maria Tirado Giraldo, and Andres Felipe Escobar González. "¿Es COVID-19 una enfermedad que afecta la médula ósea? Experiencia en donantes sanos de células hematopoyéticas en un centro de trasplante." Pediatría 55, no. 4 (2023): 176–80. http://dx.doi.org/10.14295/rp.v55i4.399.

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Objetivo: escribir y analizar el efecto de la infección por el virus SARS-CoV-2 sobre la movilización de células en donantes de precursores hematopoyéticos que acudieron a la unidad de trasplante de precursores hematopoyéticos de una institución médica de alta complejidad en Medellín, Colombia. Métodos: estudio transversal retrospectivo analítico basado en registros médicos de pacientes sometidos a trasplante de médula ósea en una entre marzo de 2020 y marzo de 2021.Resultados: de 64 donantes y receptores de células hematopoyéticas, el 22.2 % de los receptores con antecedentes positivos de inf

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19

Zinzani, Pier Luigi, Juan Carlos Dupont, Alessandra Tucci, et al. "Nemtabrutinib, a Noncovalent Reversible BTK Inhibitor in Relapsed or Refractory Marginal Zone Lymphoma: Results from the Phase 2 Bellwave-003 Study." Blood 144, Supplement 1 (2024): 3016. https://doi.org/10.1182/blood-2024-201646.

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Introduction: Covalent Bruton tyrosine kinase inhibitors (BTKi) are approved for the treatment of relapsed/refractory (R/R) marginal zone lymphoma (MZL), but patients who progress or are intolerant may have limited subsequent options. Nemtabrutinib is a once daily, potent, noncovalent, reversible BTKi with a distinct kinase profile that inhibits BTK and other B-cell receptor relevant kinases. Here, we present safety and efficacy results from the phase 2 BELLWAVE-003 study (NCT04728893) of nemtabrutinib at the recommended phase 2 dose (RP2D) in participants (pts) with R/R MZL. Methods: The mult

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Qureshi, Anina, Ihsan Shah, Quran Ul Ain, Saleha Haider, and Arfa Saqib. "Exploring the demographic variables, disease burden, and pharmacotherapy in diabetes type II and related co-morbidities: Insights for tailored healthcare strategies." Journal of Shifa Tameer-e-Millat University 7, no. 2 (2024): 175–83. https://doi.org/10.32593/jstmu/vol7.iss2.352.

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Introduction: Type 2 diabetes mellitus is a prevalent metabolic disorder with significant implications for public health, particularly in developing countries. Its management involves combination of pharmacotherapy and lifestyle modifications. This study aims to explore demographic factors, disease burden, and pharmacotherapy patterns providing insights into current practices and areas for improvement in healthcare delivery. Methodology: This study investigates prescribing patterns and indicators of diabetes management in outpatients in Islamabad and Rawalpindi. The study collected recent pres

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21

Bower, Regina S., Elaine Wirrell, Macaulay Nwojo, Nicholas M. Wetjen, W. Richard Marsh, and Fredric B. Meyer. "Seizure Outcomes After Corpus Callosotomy for Drop Attacks." Neurosurgery 73, no. 6 (2013): 993–1000. http://dx.doi.org/10.1227/neu.0000000000000161.

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Abstract BACKGROUND: Medically intractable epilepsy involving drop attacks can be difficult to manage and negatively affect quality of life. Most studies investigating the effect of corpus callosotomy (CC) on seizures have been limited, focusing on the pediatric population or drop seizures alone, with little attention to other factors influencing seizure outcome. OBJECTIVE: To assess seizure outcomes after CC in adults and children. METHODS: Retrospective analysis was performed on all patients who underwent CC (anterior two thirds, 1- or 2-stage complete) at our institution between 1990 and 20

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22

Kavanagh, Nolan M., Margaret McConnell, and Natalie Slopen. "State Minimum Wage and Mental Health Among Children and Adolescents." JAMA Network Open 7, no. 10 (2024): e2440810. http://dx.doi.org/10.1001/jamanetworkopen.2024.40810.

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ImportanceMental health disorders are increasing for children and adolescents in the US, with those in poverty having especially high rates. More evidence is needed about the association between economic policies, such as the minimum wage, and children’s mental health.ObjectiveTo test the association between minimum wages and the mental health of children and adolescents.Design, Setting, and ParticipantsThis repeated cross-sectional, population-based US study used data from 2001 to 2022. Participants included state-representative, stratified random samples of children from the National Survey

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Leitch, Heather A., Dominic H. C. Wong, Chantal S. Leger, et al. "Improved Leukemia-Free and Overall Survival in Patients with Myelodysplastic Syndrome Receiving Iron Chelation Therapy: A Subgroup Analysis." Blood 110, no. 11 (2007): 1469. http://dx.doi.org/10.1182/blood.v110.11.1469.1469.

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Abstract Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis and risk of progression to acute myeloid leukemia (AML). Many MDS patients (pts) require red blood cell (RBC) transfusions, risking iron overload (IOL)-related organ dysfunction. We previously showed in a multivariate analysis of 178 pts, improved survival in 18 pts with low and int-1 IPSS risk MDS and IOL receiving iron chelation therapy (ICT), and now examine the effect of ICT on AML-free survival (LFS). The effect of ICT on cytopenias and RBC transfusion requirements (TR); was also examined. To control for

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Song, Jae Hwang, Chan Kang, Deuk Soo Hwang, Dong Hun Kang, and June Woo Park. "Extended Sinus Tarsi Approach for Treatment of Displaced Intraarticular Calcaneal Fractures Compared to Extended Lateral Approach." Foot & Ankle International 40, no. 2 (2018): 167–77. http://dx.doi.org/10.1177/1071100718803333.

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Background: We compared the radiographic results and clinical outcomes of patients operated on via the extended sinus tarsi approach (ESTA) and the extended lateral approach (ELA) for treatment of displaced intraarticular calcaneal fractures. Methods: We retrospectively studied the utility of the ELA (46 patients, 52 feet) and the ESTA (56 patients, 64 feet) in patients operated on between January 2009 and March 2015. We evaluated pre- and postoperative x-rays and computed tomography (CT) data. Pain, patient-reported functional outcomes, satisfaction, and postoperative complications were inves

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Estrada, Leah V., Veronica Barcelona, Lara Dhingra, et al. "Potentially Avoidable Hospitalizations Among Historically Marginalized Nursing Home Residents." JAMA Network Open 7, no. 5 (2024): e249312. http://dx.doi.org/10.1001/jamanetworkopen.2024.9312.

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ImportanceNursing home (NH) transfers to hospitals are common and have been associated with cognitive decline; approximately 45% of NH hospital transfers are potentially avoidable hospitalizations (PAHs).ObjectiveTo determine PAH incidence for historically marginalized NH residents with severe cognitive impairment compared with non-Hispanic White residents.Design, Setting, and ParticipantsThis cross-sectional study merged 2018 Centers for Medicaid &amp;amp; Medicare Services datasets and LTCFocus, a public dataset on US NH care, for US NH residents aged 65 years and older who had a hospita

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26

Langwaldt, Jörg. "Bioleaching of Multimetal Black Shale by Thermophilic Micro-Organisms." Advanced Materials Research 20-21 (July 2007): 167. http://dx.doi.org/10.4028/www.scientific.net/amr.20-21.167.

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In this work the leaching of black shale ore and froth flotation concentrates produced from the black shale was studied. The complex black shale contained various sulphide minerals (alabandite, sphalerite, pyrrhotite, pentlandite, violarite, chalcopyrite, pyrite). Concentrations of base metals in the ore were Fe 13.2%, Mn 0.97%, Ni 0.3%, Zn 0.57%, Cu 0.23% and Co 0.03%. The base metal content was two to three times higher in the flotation concentrate than in the ore. Ore and concentrate were leached in shake flasks and stirred tank reactors at pulp density of 10 to 20%, pH 1.2 to 2.0 and 60 to

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Giacomazzi, Juliana, Marcia S. Graudenz, Cynthia ABT Osorio, et al. "Association between the founder brazilian TP53 p.R337H mutation and HER2-positive status." Journal of Clinical Oncology 31, no. 15_suppl (2013): e22154-e22154. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e22154.

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e22154 Background: Recent studies in North American and British series have suggested an association between germline TP53 mutations and early onset HER2-positive breast cancer (BC). Mutations in the TP53 gene are estimated to occur in 1:2,000-1:5,000 individuals of the general population. Among women with BC who are unselected for family history they occur in up to 0.25%. In women with early-onset BC (<30 years) they occur in up to 7%. A specific germline TP53 mutation (c.1010G>A; p.R337H) has been encountered in 0.3% of the general population, in 13.3% of Li-Fraumeni-like families and

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Milaknytė, Aistė, Indrė Juzelskytė, Žana Bumbulienė, and Gražina Stanislava Drąsutienė. "PAAUGLIŲ POŽIŪRIS Į SEKSUALUMĄ." Sveikatos mokslai 24, no. 4 (2014): 5–10. http://dx.doi.org/10.5200/sm-hs.2014.061.

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Darbo metodika. Vienmomentė anketinė apklausa vykdyta Vilniaus miesto (I gr.) (5 vidurinės, 2 gim- nazijos) ir Vilniaus rajono (II gr.) (1 vidurinė, 4 gim- nazijos) mokyklose 2012-2013 mokslo metais. Ap- klausta 711 aštuoniolikmečių. Rezultatai. I gr. sudarė 509 (71,6%), II gr. – 202 (28,4%) respondentai. Iš viso anketas užpildė 385 (54,1%) merginos ir 326 (45,9%) vaikinai. Lyti- nį gyvenimą pradėję 291 (40,9%) paaugliai: I gr. 221 (43,4%) ir II gr. 70 (34,7%) (p0,05), motyvai - meilė partneriui 146 (50,2%) ir vakarėlis su drau- gais 64 (22%). Lytinio gyvenimo pradžios vidur- kis 16,3±1,1 m. (

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Yoda, Akinori, Daisuke Morishita, Akio Mizutani, et al. "CTX-712, a Novel Clk Inhibitor Targeting Myeloid Neoplasms with SRSF2 Mutation." Blood 134, Supplement_1 (2019): 404. http://dx.doi.org/10.1182/blood-2019-131559.

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Splicing factors (SFs) are among the most frequent mutational targets in myeloid neoplasms, particularly in myelodysplastic syndromes (MDS) and a subset of acute myeloid leukemia (AML), designated as 'chromatin/spliceosome-mutated AML, where major SFs mutated include SF3B1, SRSF2, U2AF1, and ZRSR2. These SF mutations are largely mutually exclusive and except for ZRSR2 mutations, are invariably heterozygous, showing prominent hotspots, suggesting that mutations have neomorphic functions and might cause a synthetic lethality when they are homozygous or two SFs are mutated. Thus, SF functions mig

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Tatsui, Claudio E., Sun-Ho Lee, Behrang Amini, et al. "Spinal Laser Interstitial Thermal Therapy." Neurosurgery 79, suppl_1 (2016): S73—S82. http://dx.doi.org/10.1227/neu.0000000000001444.

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Abstract BACKGROUND: Although surgery followed by radiation effectively treats metastatic epidural compression, the ideal surgical approach should enable fast recovery and rapid institution of radiation and systemic therapy directed at the primary tumor. OBJECTIVE: To assess spinal laser interstitial thermotherapy (SLITT) as an alternative to surgery monitored in real time by thermal magnetic resonance (MR) images. METHODS: Patients referred for spinal metastasis without motor deficits underwent MR-guided SLITT, followed by stereotactic radiosurgery. Clinical and radiological data were gathere

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Stühmann, Lena M., Rebecca Paprott, Christin Heidemann, et al. "Health App Use and Its Correlates Among Individuals With and Without Type 2 Diabetes: Nationwide Population-Based Survey." JMIR Diabetes 5, no. 2 (2020): e14396. http://dx.doi.org/10.2196/14396.

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Background Evidence suggests that mobile health app use is beneficial for the prevention and management of type 2 diabetes (T2D) and its associated complications; however, population-based research on specific determinants of health app use in people with and without T2D is scarce. Objective This cross-sectional study aimed to provide population-based evidence on rates and determinants of health app use among adults with and without T2D, thereby covering a prevention perspective and a diabetes management perspective, respectively. Methods The study population included 2327 adults without a kno

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Gazzah, Anas, Joon Sang Lee, Emma Wang, et al. "Abstract CT213: Biomarker analysis from Phase 1/2 study of tusamitamab ravtansine (SAR408701) in patients with advanced non-small cell lung cancer (NSCLC)." Cancer Research 83, no. 8_Supplement (2023): CT213. http://dx.doi.org/10.1158/1538-7445.am2023-ct213.

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Abstract Background Tusamitamab ravtansine is an antibody-drug conjugate of a humanized carcinoembryonic antigen (CEA)-related cell adhesion molecule 5 (CEACAM5)-specific monoclonal antibody linked to DM4. A Phase 1/2 study (NCT02187848) showed tusamitamab ravtansine antitumor activity in pretreated patients (pts) with advanced nonsquamous NSCLC and high CEACAM5 expression. Here, we explore biomarker associations with tumor CEACAM5 expression by immunohistochemistry (IHC), and whether biomarkers predict objective response rate (ORR). Methods We assessed CEACAM5 expression by IHC, RNA sequencin

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Wenzel, Mike, Florestan Koll, Benedikt Hoeh, et al. "Real-world comparison of cabazitaxel vs. 177-lutetium-PSMA radioligand therapy in metastatic castration resistant prostate cancer." Journal of Clinical Oncology 43, no. 5_suppl (2025): 70. https://doi.org/10.1200/jco.2025.43.5_suppl.70.

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70 Background: 177-Lutetium Prostate-specific membrane antigen (Lu-PSMA) therapy is under current scientific investigation and aims to become an established part in treatment of metastatic castration resistant prostate cancer (mCRPC). However, real-world evidence in treatment comparison is scant. Methods: We relied on the FRAMCAP database and compared cabazitaxel vs. Lu-PSMA therapy in mCRPC patients regarding progression-free (PFS) and overall (OS). Sensitivity analyses addressed 2 nd to 4 th line mCRPC patients to approximate current Phase-III patient selection criteria. Results: Of 373 mCRP

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Zeng, Ying, Chen Long, Wei Zhao, and Jun Liu. "Predicting the Severity of Neurological Impairment Caused by Ischemic Stroke Using Deep Learning Based on Diffusion-Weighted Images." Journal of Clinical Medicine 11, no. 14 (2022): 4008. http://dx.doi.org/10.3390/jcm11144008.

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Purpose: To develop a preliminary deep learning model that uses diffusion-weighted imaging (DWI) images to classify the severity of neurological impairment caused by ischemic stroke. Materials and Methods: This retrospective study included 851 ischemic stroke patients (711 patients in the training set and 140 patients in the test set). The patients’ NIHSS scores, which reflect the severity of neurological impairment, were reviewed upon admission and on Day 7 of hospitalization and were classified into two stages (stage 1 for NIHSS < 5 and stage 2 for NIHSS ≥ 5). A 3D-CNN was trained to pred

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Serrano-Rodríguez, Anay, Griselda Escalona Segura, Alexis H. Plasencia Vázquez, Eduardo E. Iñigo Elias, and Lorena Ruiz-Montoya. "Distribución potencial y conectividad del paisaje: criterios para reevaluar el grado de amenaza de Campylorhynchus yucatanicus (Aves: Troglodytidae)." Revista de Biología Tropical 65, no. 4 (2017): 1554. http://dx.doi.org/10.15517/rbt.v65i4.26599.

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Geographic distribution and habitat quality are key criteria for assessing the degree of risk of species extinction threat. Campylorhynchus yucatanicus (Yucatán Wren, Troglodytidae) is an endemic bird of the Northern coast of the Yucatán Peninsula, Mexico, with a distribution restricted to a narrow strip of habitat, between Campeche and Yucatán states. Currently, the Yucatán coast has lost more than half of the coastal dune vegetation, and other habitats have been modified mainly because there is no urban development plan and the natural resources management is poor. These factors threaten C.

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Mishra, Vinod, Shyam Thapa, Robert D. Retherford, and Xiaolei Dai. "Effect of Iron Supplementation during Pregnancy on Birthweight: Evidence from Zimbabwe." Food and Nutrition Bulletin 26, no. 4 (2005): 338–47. http://dx.doi.org/10.1177/156482650502600403.

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Background Iron deficiency in pregnant women has been shown to reduce the oxygen supply to the fetus, cause intrauterine growth retardation, and increase the risk of premature delivery and reduced birthweight. Yet the effects of iron supplementation programs on pregnancy outcomes are not well documented for developing countries. Objective To examine the relation between iron supplementation of mothers during pregnancy and children's birthweight using data from a national population-based survey in Zimbabwe. Methods The analysis uses information on 3,559 births during the five years preceding t

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Crowley, Samuel J., Prabesh Kanel, Stiven Roytman, Nicolaas I. Bohnen, and Benjamin M. Hampstead. "1 Basal Forebrain Free Water Fraction is Associated with Cortical Cholinergic Levels in Idiopathic Parkinson’s Disease." Journal of the International Neuropsychological Society 29, s1 (2023): 108–9. http://dx.doi.org/10.1017/s1355617723001996.

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Objective:Cognitive dysfunction is a common non-motor symptom of Parkinson’s disease (PD). Cognitive decline in PD is likely associated with dysfunction in the cholinergic system, which is affected by synuclein pathology early in the disease course. Recent studies have shown an association between reduced integrity of the basal forebrain (BF), which provides cholinergic innervation to most of cortex, and diminished cognitive functioning in PD. Specifically, those with PD and reduced cholinergic innervation also have higher rates of cognitive impairment. However, no study has directly investiga

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Ni, Haosen, Huabin Wang, Xuefeng Ma, et al. "Efficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder." JAMA Network Open 7, no. 6 (2024): e2416684. http://dx.doi.org/10.1001/jamanetworkopen.2024.16684.

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ImportanceThe Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR), recently identified internet gaming disorder (IGD) as a condition warranting more research, and few empirically validated treatments exist. Mindfulness meditation (MM) has multiple health benefits; however, its efficacy in treating IGD and potential neural mechanisms underlying MM treatment of the disorder remain largely unknown.ObjectiveTo explore the efficacy of MM used to treat adults with IGD and to identify neural mechanisms underlying MM.Design, Setting, and ParticipantsThis rand

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Patel, Anuj Bharatkumar, Vicky Mai, Lucia Caiano, et al. "Fatal Pulmonary Embolism, Fatal Bleeding and Intracranial Hemorrhage with Systemic and Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism: A Systematic Review with Meta-Analysis." Blood 142, Supplement 1 (2023): 2644. http://dx.doi.org/10.1182/blood-2023-182859.

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Background: Thrombolysis, either systemic (ST) or catheter-directed (CDT), may reduce mortality in patients with intermediate-high and high-risk pulmonary embolism (PE), but with an increased risk of major bleeding (MB). Moreover, uncertainties remain for other efficacy and safety outcomes, such as fatal PE, fatal bleeding, and intracranial hemorrhage (ICH). Aims: To evaluate fatal PE, fatal bleeding and ICH with ST and CDT in patients with intermediate-high and high-risk PE. Methods: We performed a systematic search in MEDLINE, EMBASE and Cochrane from inception to December 2022. Randomized t

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McGuine, Timothy A., Adam Y. Pfaller, Eric G. Post, Scott J. Hetzel, Alison Brooks, and Steven P. Broglio. "The Influence of Athletic Trainers on the Incidence and Management of Concussions in High School Athletes." Journal of Athletic Training 53, no. 11 (2018): 1017–24. http://dx.doi.org/10.4085/1062-6050-209-18.

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Context In many US high schools, the athletic trainer (AT) has the responsibility to identify and manage athletes with concussions. Although the availability of ATs varies a great deal among schools, how the level of AT availability in high schools affects the reported incidence and management of sport-related concussions (SRCs) is unknown. Objective To determine how the presence of an AT affects the reporting and management of SRCs. Design Prospective cohort study. Patients or Other Participants A total of 2459 (female = 37.5%, age = 16.1 ± 1.2 years) athletes from 31 Wisconsin high schools w

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Saligan, Leorey. "The effects of androgen deprivation therapy and radiation therapy on cancer-related fatigue." Journal of Clinical Oncology 37, no. 31_suppl (2019): 10. http://dx.doi.org/10.1200/jco.2019.37.31_suppl.10.

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10 Background: Fatigue is a common symptom characterized by incapacitating tiredness. Androgen deprivation therapy (ADT) in combination with radiotherapy (RT) is one of the standard treatments for prostate cancer. Fatigue often worsens during RT with concomitant ADT and it persists long after treatment completion. The purpose of this study is to examine the effects of combined ADT and RT on fatigue in prostate cancer men and in a fatigue mouse model. Methods: 64 participants were recruited and followed at baseline, midpoint, completion, and 1 year post-RT. Two cohorts of men: +ADT cotinued aft

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Brammer, Melissa, Deepa Lalla, Geneviève Gauthier, et al. "Comparison of discontinuation, health care resource utilization (HRU), and costs between metastatic breast cancer (mBC) patients (pts) who received trastuzumab (T) in an office clinic versus outpatient hospital setting." Journal of Clinical Oncology 31, no. 15_suppl (2013): 642. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.642.

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642 Background: T treatment for mBC may be administered in an office clinic or outpatient hospital setting. This study assesses the impact of the site of care on T discontinuation risk, HRU, and costs. Methods: Adult women with mBC who received ≥2 T infusions in an outpatient hospital or office clinic setting were selected from the US-based Humana database (2007-2012). Pts were required to be continuous eligible in their healthcare plan for ≥6 months prior and ≥2 months following the first T infusion (index date). Pts were classified, based on their index site of care, into one of the followin

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Bektaş, M., S. Yüce, M. Ay, M. Uyar, M. Önder, and M. İ. Kiliç. "POS0555 HIGH DOSE INTRAVENOUS ANAKINRA TREATMENT IS SAFE AND EFFECTIVE IN SEVERE AND CRITICAL COVID-19 PATIENTS: A PROPENSITY SCORE MATCHED STUDY IN A SINGLE CENTER." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 544. http://dx.doi.org/10.1136/annrheumdis-2023-eular.339.

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BackgroundIn COVID-19 severe disease course such as need of intensive care unit (ICU) as well as development of mortality is mainly due to cytokine storm.ObjectivesIn this study, we aimed to evaluate the high dose intravenous anakinra treatment response and outcome in patients with severe and critical COVID-19 compared to standard of care.MethodsThis retrospective observational study was carried out at a tertiary referral center. The study population consisted of two groups as follows; the patients receiving high dose intravenous anakinra (anakinra group) between 01.09.2021 and 01.02.2022 and

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Ying, Lee Hui, Rashmika Nambiar, Mohd Fit’ri Akmal Mohd Sofee, et al. "A REVIEW OF CONGENITAL HYPOTHYROIDISM AND ROLE OF THYROID SCINTIGRAPHY IN UNIVERSITY MALAYA MEDICAL CENTRE (UMMC)." Journal of the ASEAN Federation of Endocrine Societies 40, S1 (2025): 133. https://doi.org/10.15605/jafes.040.s1.225.

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INTRODUCTIONThyroid scintigraphy (TS) is the gold standard investigation to determine the underlying cause of congenital hypothyroidism (CHT), which can be due to thyroid dysgenesis (agenesis/hypoplasia/ectopic), dyshormonogenesis (TDH), or transient hypothyroidism (TH). In Malaysia, thyroid scan is done at the age of 3 years old. Some centres may opt to do ultrasound instead. METHODOLOGYThis is a retrospective study from 2020 to 2023. TS in UMMC uses radioactive tracer technetium-99m. All patients suspected of having congenital hypothyroidism (CHT) or neonatal-onset hypothyroidism were subjec

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Tesch, Megan E., Yaileen D. Guzman Arocho, Laura C. Collins, et al. "Association of tumor-infiltrating lymphocytes (TILs) with clinicopathologic characteristics and prognosis in young women with HR+/HER2- breast cancer (BC)." Journal of Clinical Oncology 41, no. 16_suppl (2023): 505. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.505.

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505 Background: Increased TILs are associated with better prognosis in triple-negative BC, including in patients (pts) age < 40. However, the role of TILs remains unclear in HR+/HER2- BC and little data exist in young pts, in whom immune microenvironment could be altered by age-related host/tumor differences. We assessed the extent and composition of immune infiltration in HR+ tumors of young women and correlated with clinicopathologic features and survival outcomes. Methods: From a prospective cohort study of women with BC diagnosed age ≤40, we identified those with stage I-III HR+/HER2- B

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Kádár, Imre. "Műtrágyahatások vizsgálata a 2. éves telepített gyepen. Ásványi elemfelvétel. 7." Gyepgazdálkodási Közlemények 4, no. 1-2 (2021): 107–18. http://dx.doi.org/10.55725/gygk/2006/4/1-2/10384.

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Egy műtrágyázási tartamkísérlet 29. évében, 2002-ben vizsgáltuk az eltérő N, P és K ellátottsági szintek és kombinációik hatását a réti csenkesz (Festuca pratensis) vezérnövényű, nyolckomponensű pillangós nélküli gyepkeverék 2. évének termésére és elemtartalmára. A termőhely talaja a szántott rétegben mintegy 3% humuszt, 3-5% CaCO3-ot és 20-22% agyagot tartalmazott, N és K elemekben közepesen, P és Zn elemekben gyengén ellátottnak minősült. A kísérlet 4N× 4P×4K=64 kezelést × 2 ismétlést=128 parcellát foglalt magában. A talajvíz 13-15 m mélyen helyezkedik el, a terület aszályérzékeny.A vizsgált

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Zhang, Yi, Qi Yang, Biao Song, et al. "Efficacy and safety of Piwei Peiyuan Prescription in the treatment of chronic atrophic gastritis: A multicenter, double-blind, double-simulated, randomized, controlled clinical trial." Medicine 103, no. 19 (2024): e37981. http://dx.doi.org/10.1097/md.0000000000037981.

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The incidence of chronic atrophic gastritis (CAG) is on the rise due to the growing pressure in modern social life, increasing bad living habits and emotional disorders (such as anxiety and depression), and the aging of the population. Of note, digestive system diseases are the dominant diseases in the field of traditional Chinese medicine (TCM). Therefore, this study evaluated the efficacy and safety of Piwei Peiyuan Prescription, a TCM prescription, in the treatment of CAG through a multicenter, double-blind, randomized, controlled design. This research was organized by the Second Affiliated

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Tyagi, Shachi, Becky Clarkson, Kandy Newell, Subashan Perera, Neil Resnick, and Daniel Buysse. "0822 Sleep and Nighttime Urine Production." SLEEP 46, Supplement_1 (2023): A362. http://dx.doi.org/10.1093/sleep/zsad077.0822.

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Abstract Introduction Nocturia (waking from sleep to urinate) is the most common cause of sleep interruption among older adults and nocturnal polyuria (NP; increased sleep time urine production) is its most common cause. Conversely, poor sleep with repeated awakenings contributes to both nocturia and NP. However, whether a behavioral intervention to reduce repeated awakenings can improve nocturia and NP has not been examined in a clinical trial. The current study assesses the effect of Brief Behavioral Treatment for Insomnia (BBTI) on nocturia and NP in older adults. Methods Fifty-six communit

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Yau, Thomas Cheung, Vikki Tang, Roland Ching-Yu Leung, et al. "Randomized phase II trial of sorafenib, capecitabine and oxaliplatin (SECOX) versus single agent sorafenib in patients with advanced hepatocellular carcinoma." Journal of Clinical Oncology 37, no. 4_suppl (2019): 365. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.365.

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365 Background: We aimed to compare the efficacy and tolerability of SECOX regimen with sorafenib alone as first-line treatment of advanced hepatocellular cancer (HCC) in a multicenter, open-label and randomized setting. Methods: Patients not suitable for surgery or various loco-regional therapies and no prior systemic therapy for advanced HCC were recruited in 3 centres. Eligible patients were randomly assigned to receive either SECOX (sorafenib 400 mg BD continuously, oxaliplatin 85 mg/m2 on D1, and capecitabine 1700 mg/m2 on D1-7 q2w) or sorafenib alone continuously in 1:1 ratio. Primary en

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Kwok, Gin Wai, Vikki Tang, Roland Ching-Yu Leung, et al. "Randomized phase II trial of sorafenib, capecitabine, and oxaliplatin (SECOX) versus single agent sorafenib in patients with advanced hepatocellular carcinoma." Journal of Clinical Oncology 37, no. 15_suppl (2019): e15630-e15630. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e15630.

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e15630 Background: We aimed to compare the efficacy and tolerability of SECOX regimen with sorafenib alone as first-line treatment of advanced hepatocellular cancer (HCC) in a multicenter, open-label and randomized setting. Methods: Patients not suitable for surgery or various loco-regional therapies and no prior systemic therapy for advanced HCC were recruited in 3 centres. Eligible patients were randomly assigned to receive either SECOX (sorafenib 400 mg BD continuously, oxaliplatin 85 mg/m2 on D1, and capecitabine 1700 mg/m2 on D1-7 q2w) or sorafenib alone continuously in 1:1 ratio. Primary

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