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Добірка наукової літератури з теми "72.01(477) (042.3)"

Автор: Grafiati

Опубліковано: 30 травня 2022

Оновлено: 31 липня 2025

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Статті в журналах з теми "72.01(477) (042.3)"

1

Coates, L. C., R. B. Warren, C. T. Ritchlin, et al. "POS1022 BIMEKIZUMAB SAFETY AND EFFICACY IN PATIENTS WITH PSORIATIC ARTHRITIS: 3-YEAR RESULTS FROM A PHASE 2b OPEN-LABEL EXTENSION STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 779–80. http://dx.doi.org/10.1136/annrheumdis-2021-eular.124.

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Background:Bimekizumab (BKZ), a monoclonal antibody inhibitor of interleukin (IL)-17A and IL-17F, demonstrated clinical improvements in joint and skin outcomes up to 108 weeks (wks) in patients (pts) with active psoriatic arthritis (PsA).1,2Objectives:To report up to 3-year safety and efficacy of BKZ in pts with active PsA from a 48-week phase 2b dose-ranging study (BE ACTIVE; NCT02969525) and its open-label extension (OLE; NCT03347110).Methods:BE ACTIVE and OLE study design has been described previously.1 All OLE pts received BKZ 160 mg Q4W, irrespective of prior dosing regimen. Treatment-eme

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2

Zhao, Kanhao, Hua Xie, Gregory A. Fonzo, Nancy B. Carlisle, Ricardo S. Osorio, and Yu Zhang. "Dementia Subtypes Defined Through Neuropsychiatric Symptom–Associated Brain Connectivity Patterns." JAMA Network Open 7, no. 7 (2024): e2420479. http://dx.doi.org/10.1001/jamanetworkopen.2024.20479.

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ImportanceUnderstanding the heterogeneity of neuropsychiatric symptoms (NPSs) and associated brain abnormalities is essential for effective management and treatment of dementia.ObjectiveTo identify dementia subtypes with distinct functional connectivity associated with neuropsychiatric subsyndromes.Design, Setting, and ParticipantsUsing data from the Open Access Series of Imaging Studies-3 (OASIS-3; recruitment began in 2005) and Alzheimer Disease Neuroimaging Initiative (ADNI; recruitment began in 2004) databases, this cross-sectional study analyzed resting-state functional magnetic resonance

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3

Walker, C. D., R. W. Rivest, M. J. Meaney, and M. L. Aubert. "Differential activation of the pituitary-adrenocortical axis after stress in the rat: use of two genetically selected lines (Roman low- and high-avoidance rats) as a model." Journal of Endocrinology 123, no. 3 (1989): 477–85. http://dx.doi.org/10.1677/joe.0.1230477.

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ABSTRACT We have examined the activation of the pituitary-adrenal axis in two lines of rats, the Roman high (RHA)- and low (RLA)-avoidance rats known to be emotionally different. These rats are selected for rapid acquisition of a conditioned avoidance response (RHA) compared with failure to acquire this response (RLA). In this study the endocrine response (ACTH, corticosterone, aldosterone) of RLA and RHA rats to two types of stress was examined: exposure to openfield stress for 10 min (Op) or exposure to ether vapours for 3 min (E). Basal plasma ACTH concentrations were lower in RLA than in R

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4

McCarthy, Philip L., Theresa Hahn, Anna Hassebroek, et al. "Significant Improvement In Overall Survival In Patients Who Underwent Autologous Hematopoietic Cell Transplant In the US or Canada Between 1994 and 2005." Blood 116, no. 21 (2010): 2389. http://dx.doi.org/10.1182/blood.v116.21.2389.2389.

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Abstract Abstract 2389 Autologous hematopoietic cell transplantation (autoHCT) is standard therapy for high-risk hematologic disorders and solid tumors. We assessed whether overall survival (OS) at Day 100, which represents early transplant-related mortality (TRM), and at one year, which represents disease-related mortality and later TRM, had changed over time. The study population was derived from patients undergoing 68,404 first autoHCTs between 1994–2005 in US and Canadian centers reported to the CIBMTR. Statistical significance was measured using Ptrend over 6 time cohorts to test whether

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5

Combe, B., Y. Tanaka, P. Emery, et al. "POS0679 CLINICAL OUTCOMES UP TO WEEK (W) 48 IN THE ONGOING FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL OF RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) WITH INADEQUATE RESPONSE (IR) TO METHOTREXATE (MTX) INITIALLY TREATED WITH FIL OR ADALIMUMAB (ADA) DURING THE PHASE 3 PARENT STUDY (PS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 615–16. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1641.

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BackgroundThe preferential Janus kinase-1 inhibitor FIL is approved for treatment of moderate to severe active RA in Europe and Japan.ObjectivesEfficacy and safety of FIL were assessed in pts with IR to MTX who completed a Phase 3 trial (NCT02889796)1 and enrolled in an LTE (NCT03025308).MethodsPts completing the PS1 on study drug were eligible to enter the LTE (data cutoff: June 1, 2020). Median exposure: 2.2 years (y). Efficacy data to W48 are reported for 4 treatment groups (all with background MTX): pts receiving FIL 200 mg (FIL200) or FIL 100 mg (FIL100) in the PS and continuing their dos

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6

TUMMARUK, P., W. TANTASUPARUK, M. TECHAKUMPHU, and A. KUNAVONGKRIT. "Seasonal influences on the litter size at birth of pigs are more pronounced in the gilt than sow litters." Journal of Agricultural Science 148, no. 4 (2010): 421–32. http://dx.doi.org/10.1017/s0021859610000110.

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SUMMARYThe aim of the present study was to use data from herds to demonstrate the degree of seasonal influence on litter size at birth in gilts compared to sow parities 2, 3–5 and older (parities ⩾6) in a conventional, open-housing system for commercial pig herds in the northeastern part of Thailand. Data were obtained during a 3-year period from July 2005 to June 2008. The data analysed included observations on 25 835 litters from 8100 sows. Total number of piglets born per litter (TB), number of piglets born alive per litter (BA), proportion of stillborn piglets per litter (SB) and proportio

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7

Hartridge-Lambert, Sidonie K., Heiko Schoder, Remy C. Lim, Jocelyn C. Maragulia, and Carol S. Portlock. "Six Cycles of ABVD and a Negative PET Scan Negates the Need for Radiologic Follow-up in Early Stage, Non-Bulky Hodgkin Lymphoma: MSKCC Retrospective Analysis." Blood 118, no. 21 (2011): 3139. http://dx.doi.org/10.1182/blood.v118.21.3139.3139.

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Abstract Abstract 3139FN2 Introduction: Early stage, non-bulky (nb) classical Hodgkin lymphoma (cHL) patients receive intensive radiologic surveillance after completion of standard therapy despite a statistically low risk of relapse. This study sought to evaluate the relapse risk and value of radiologic surveillance in this subset of patients treated with 6 cycles of ABVD who achieve a PET negative complete remission (CR). Methods: We identified all early-stage, nb cHL patients who were treated with 6 cycles of ABVD at MSKCC from 01/2002 to 12/2008. To be eligible for the study, patients had t

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8

Andrade-Gonzalez, Xavier, Raphael Mwangi, Jithma P. Abeykoon, et al. "Impact of Double Hit Lymphoma and Cell of Origin in the Risk of Central Nervous System Relapse in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma." Blood 138, Supplement 1 (2021): 1439. http://dx.doi.org/10.1182/blood-2021-151973.

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Abstract Introduction: Central nervous system (CNS) relapse is an uncommon but devastating complication occurring in about 2-10% of patients with diffuse large B-cell lymphoma (DLBCL). The CNS-IPI is a validated prognostic tool used to identify patients at high risk of CNS relapse. MYC and BCL2/BCL6 rearrangements (double-hit lymphoma- DHL) and non-GCB (NGCB) cell of origin may be at higher risk of CNS relapse. However, the ability of these molecular data to refine CNS-IPI risk prediction has not been assessed. In this study, we aimed to describe the impact of DHL and NGCB cell of origin in th

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9

Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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10

Goffin, Kay, Marc van Maris, and Ronald J. Corbee. "Effects of matrix on plasma levels of EPA and DHA in dogs." Journal of Nutritional Science 6 (2017). http://dx.doi.org/10.1017/jns.2017.30.

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AbstractEPA and DHA are often used in veterinary medicine due to their beneficial effects for several medical conditions such as osteoarthritis. EPA and DHA are administered to dogs through different matrices. The aim of the present study was to determine the effects on the plasma levels in dogs caused by various matrices for EPA and DHA administration. In this study, three different n-3 PUFA formulations were used: soft chew tablet (CCx); liquid fish oil (LFO); and enriched kibbles (EK). The formulations were administered single-dose and compared in a randomised, cross-over designed study wit

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