Готові списки джерел за темами / A-to-I RNA editing

Добірка наукової літератури з теми "A-to-I RNA editing"

Автор: Grafiati

Опубліковано: 14 вересня 2021

Оновлено: 21 лютого 2023

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "A-to-I RNA editing".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Статті в журналах з теми "A-to-I RNA editing":

Wulff, Bjorn‐Erik, and Kazuko Nishikura. "Substitutional A‐to‐I RNA editing." Wiley Interdisciplinary Reviews: RNA 1, no. 1 (May 21, 2010): 90–101. http://dx.doi.org/10.1002/wrna.10.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Schaffer, Amos A., Eli Kopel, Ayal Hendel, Ernesto Picardi, Erez Y. Levanon, and Eli Eisenberg. "The cell line A-to-I RNA editing catalogue." Nucleic Acids Research 48, no. 11 (May 8, 2020): 5849–58. http://dx.doi.org/10.1093/nar/gkaa305.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well as cancer. In addition, the endogenous A-to-I editing machinery has been recently harnessed for RNA engineering. The study of RNA editing in humans relies heavily on the usage of cell lines as an important and commonly-used research tool. In particular, manipulations of the editing enzymes and their targets are often developed using cell line platforms. However, RNA editing in cell lines behaves very differently than in normal and diseased tissues, and most cell lines exhibit low editing levels, requiring over-expression of the enzymes. Here, we explore the A-to-I RNA editing landscape across over 1000 human cell lines types and show that for almost every editing target of interest a suitable cell line that mimics normal tissue condition may be found. We provide CLAIRE, a searchable catalogue of RNA editing levels across cell lines available at http://srv00.recas.ba.infn.it/atlas/claire.html, to facilitate rational choice of appropriate cell lines for future work on A-to-I RNA editing.

Sapiro, Anne L., Anat Shmueli, Gilbert Lee Henry, Qin Li, Tali Shalit, Orly Yaron, Yoav Paas, Jin Billy Li, and Galit Shohat-Ophir. "Illuminating spatial A-to-I RNA editing signatures within theDrosophilabrain." Proceedings of the National Academy of Sciences 116, no. 6 (January 18, 2019): 2318–27. http://dx.doi.org/10.1073/pnas.1811768116.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is a ubiquitous mechanism that generates transcriptomic diversity. This process is particularly important for proper neuronal function; however, little is known about how RNA editing is dynamically regulated between the many functionally distinct neuronal populations of the brain. Here, we present a spatial RNA editing map in theDrosophilabrain and show that different neuronal populations possess distinct RNA editing signatures. After purifying and sequencing RNA from genetically marked groups of neuronal nuclei, we identified a large number of editing sites and compared editing levels in hundreds of transcripts across nine functionally different neuronal populations. We found distinct editing repertoires for each population, including sites in repeat regions of the transcriptome and differential editing in highly conserved and likely functional regions of transcripts that encode essential neuronal genes. These changes are site-specific and not driven by changes inAdarexpression, suggesting a complex, targeted regulation of editing levels in key transcripts. This fine-tuning of the transcriptome between different neurons by RNA editing may account for functional differences between distinct populations in the brain.

Maas, Stefan, Yukio Kawahara, Kristen M. Tamburro, and Kazuko Nishikura. "A-to-I RNA Editing and Human Disease." RNA Biology 3, no. 1 (January 2006): 1–9. http://dx.doi.org/10.4161/rna.3.1.2495.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Garrett, Sandra C., and Joshua J. C. Rosenthal. "A Role for A-to-I RNA Editing in Temperature Adaptation." Physiology 27, no. 6 (December 2012): 362–69. http://dx.doi.org/10.1152/physiol.00029.2012.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to smaller, less stabilizing amino acids. Studies on how editing affects protein function support this idea.

Larsen, Knud, and Mads Peter Heide-Jørgensen. "Conservation of A-to-I RNA editing in bowhead whale and pig." PLOS ONE 16, no. 12 (December 9, 2021): e0260081. http://dx.doi.org/10.1371/journal.pone.0260081.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

RNA editing is a post-transcriptional process in which nucleotide changes are introduced into an RNA sequence, many of which can contribute to proteomic sequence variation. The most common type of RNA editing, contributing to nearly 99% of all editing events in RNA, is A-to-I (adenosine-to-inosine) editing mediated by double-stranded RNA-specific adenosine deaminase (ADAR) enzymes. A-to-I editing at ‘recoding’ sites results in non-synonymous substitutions in protein-coding sequences. Here, we present studies of the conservation of A-to-I editing in selected mRNAs between pigs, bowhead whales, humans and two shark species. All examined mRNAs–NEIL1, COG3, GRIA2, FLNA, FLNB, IGFBP7, AZIN1, BLCAP, GLI1, SON, HTR2C and ADAR2 –showed conservation of A-to-I editing of recoding sites. In addition, novel editing sites were identified in NEIL1 and GLI1 in bowhead whales. The A-to-I editing site of human NEIL1 in position 242 was conserved in the bowhead and porcine homologues. A novel editing site was discovered in Tyr244. Differential editing was detected at the two adenosines in the NEIL1 242 codon in both pig and bowhead NEIL1 mRNAs in various tissues and organs. No conservation of editing of KCNB1 and EEF1A mRNAs was seen in bowhead whales. In silico analyses revealed conservation of five adenosines in ADAR2, some of which are subject to A-to-I editing in bowheads and pigs, and conservation of a regulatory sequence in GRIA2 mRNA that is responsible for recognition of the ADAR editing enzyme.

Buchumenski, Ilana, Karoline Holler, Lior Appelbaum, Eli Eisenberg, Jan Philipp Junker, and Erez Y. Levanon. "Systematic identification of A-to-I RNA editing in zebrafish development and adult organs." Nucleic Acids Research 49, no. 8 (April 19, 2021): 4325–37. http://dx.doi.org/10.1093/nar/gkab247.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Abstract A-to-I RNA editing is a common post transcriptional mechanism, mediated by the Adenosine deaminase that acts on RNA (ADAR) enzymes, that increases transcript and protein diversity. The study of RNA editing is limited by the absence of editing maps for most model organisms, hindering the understanding of its impact on various physiological conditions. Here, we mapped the vertebrate developmental landscape of A-to-I RNA editing, and generated the first comprehensive atlas of editing sites in zebrafish. Tens of thousands unique editing events and 149 coding sites were identified with high-accuracy. Some of these edited sites are conserved between zebrafish and humans. Sequence analysis of RNA over seven developmental stages revealed high levels of editing activity in early stages of embryogenesis, when embryos rely on maternal mRNAs and proteins. In contrast to the other organisms studied so far, the highest levels of editing were detected in the zebrafish ovary and testes. This resource can serve as the basis for understanding of the role of editing during zebrafish development and maturity.

Washburn, Michael C., and Heather A. Hundley. "Transandcisfactors affecting A-to-I RNA editing efficiency of a noncoding editing target inC. elegans." RNA 22, no. 5 (February 25, 2016): 722–28. http://dx.doi.org/10.1261/rna.055079.115.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Han, Jian, Omer An, HuiQi Hong, Tim Hon Man Chan, Yangyang Song, Haoqing Shen, Sze Jing Tang, et al. "Suppression of adenosine-to-inosine (A-to-I) RNA editome by death associated protein 3 (DAP3) promotes cancer progression." Science Advances 6, no. 25 (June 2020): eaba5136. http://dx.doi.org/10.1126/sciadv.aba5136.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

RNA editing introduces nucleotide changes in RNA sequences. Recent studies have reported that aberrant A-to-I RNA editing profiles are implicated in cancers. Albeit changes in expression and activity of ADAR genes are thought to have been responsible for the dysregulated RNA editome in diseases, they are not always correlated, indicating the involvement of secondary regulators. Here, we uncover DAP3 as a potent repressor of editing and a strong oncogene in cancer. DAP3 mainly interacts with the deaminase domain of ADAR2 and represses editing via disrupting association of ADAR2 with its target transcripts. PDZD7, an exemplary DAP3-repressed editing target, undergoes a protein recoding editing at stop codon [Stop →Trp (W)]. Because of editing suppression by DAP3, the unedited PDZD7WT, which is more tumorigenic than edited PDZD7Stop518W, is accumulated in tumors. In sum, cancer cells may acquire malignant properties for their survival advantage through suppressing RNA editome by DAP3.

Silvestris, Domenico Alessandro, Chiara Scopa, Sara Hanchi, Franco Locatelli, and Angela Gallo. "De Novo A-to-I RNA Editing Discovery in lncRNA." Cancers 12, no. 10 (October 13, 2020): 2959. http://dx.doi.org/10.3390/cancers12102959.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Background: Adenosine to inosine (A-to-I) RNA editing is the most frequent editing event in humans. It converts adenosine to inosine in double-stranded RNA regions (in coding and non-coding RNAs) through the action of the adenosine deaminase acting on RNA (ADAR) enzymes. Long non-coding RNAs, particularly abundant in the brain, account for a large fraction of the human transcriptome, and their important regulatory role is becoming progressively evident in both normal and transformed cells. Results: Herein, we present a bioinformatic analysis to generate a comprehensive inosinome picture in long non-coding RNAs (lncRNAs), using an ad hoc index and searching for de novo editing events in the normal brain cortex as well as in glioblastoma, a highly aggressive human brain cancer. We discovered >10,000 new sites and 335 novel lncRNAs that undergo editing, never reported before. We found a generalized downregulation of editing at multiple lncRNA sites in glioblastoma samples when compared to the normal brain cortex. Conclusion: Overall, our study discloses a novel layer of complexity that controls lncRNAs in the brain and brain cancer.

Більше джерел

Дисертації з теми "A-to-I RNA editing":

Eran, Alal. "Small RNA and A-to-I editing in Autism Spectrum Disorders." Thesis, Massachusetts Institute of Technology, 2013. http://hdl.handle.net/1721.1/79243.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Thesis (Ph. D. in Bioinformatics and Integrative Genomics)--Harvard-MIT Program in Health Sciences and Technology, 2013.
Cataloged from PDF version of thesis.
Includes bibliographical references.
One in every 88 children is diagnosed with Autism Spectrum Disorders (ASDs), a set of neurodevelopmental conditions characterized by social impairments, communication deficits, and repetitive behavior. ASDs have a substantial genetic component, but the specific cause of most cases remains unknown. Understanding gene-environment interactions underlying ASD is essential for improving early diagnosis and identifying critical targets for intervention and prevention. Towards this goal, we surveyed adenosine-to-inosine (A-to-I) RNA editing in autistic brains. A-to-I editing is an epigenetic mechanism that fine-tunes synaptic function in response to environmental stimuli, shown to modulate complex behavior in animals. We used ultradeep sequencing to quantify A-to-I recoding of candidate synaptic genes in postmortem cerebella from individuals with ASD and neurotypical controls. We found unexpectedly wide distributions of human A-to-I editing levels, whose extremes were consistently populated by individuals with ASD. We correlated Ato- I editing with isoform usage, identified clusters of correlated sites, and examined differential editing patterns. Importantly, we found that individuals with ASD commonly use a dysfunctional form of the editing enzyme ADARB1. We next profiled small RNAs thought to regulate A-to-I editing, which originate from one of the most commonly altered loci in ASD, 15q11. Deep targeted sequencing of SNORD115 and SNORD116 transcripts enabled their high-resolution detection in human brains, and revealed a strong gender bias underlying their expression. The consistent 2-fold upregulation of 15q11 small RNAs in male vs. female cerebella could be important in delineating the role of this locus in ASD, a male dominant disorder. Overall, these studies provide an accurate population-level view of small RNA and A-to-I editing in human cerebella, and suggest that A-to-I editing of synaptic genes may be informative for assessing the epigenetic risk for autism.
by Alal Eran.
Ph.D.in Bioinformatics and Integrative Genomics

Ohlson, Johan. "Novel sites of A-to-I RNA editing in the mammalian brain." Doctoral thesis, Stockholm : Department of Molecular Biology and Functional Genomics, Stockholm University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7045.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Mannion, Niamh. "Elucidating the role of the RNA editing enzyme ADAR1 in the innate immune response." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17887.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

The adenosine deaminase acting on RNA (ADAR) enzymes catalyse the hydrolytic deamination of adenosine (A) to inosine (I) in double stranded (ds) RNA. Mutations in ADAR1 underlie the autoimmune disorder Aicardi Goutiѐres syndrome (AGS). Patients with AGS display heightened levels of type I interferon (IFN) and IFN stimulated genes (ISGs). The first aim of my thesis was to determine whether the mutations found in the human ADAR1 gene affected RNA editing. I found that the ADAR1 mutants identified in the AGS patients have reduced editing activity. Interestingly, the mutations have a greater effect on the IFN-inducible cytoplasmic isoform, ADAR1p150 than on the constitutive ADAR1p110 isoform. These results imply that A-to-I editing plays a role in regulating the type I IFN response. The Adar1 null mouse dies by E12.5 with a type I IFN signature similar to that observed in the AGS patients. The second aim of my thesis was to characterize the immune signalling pathway aberrantly activated in the absence of Adar1. A colleague in our research group rescued the Adar1 null mouse to birth by blocking the cellular response to cytoplasmic dsRNA by generating a double mutant with the mitochondrial antiviral signalling adaptor, Mavs. In the Adar1-/-; Mavs-/- mutant I found that the aberrant immune response is rescued at E11.5. This indicates that MAVS is the downstream adaptor in the aberrant immune response that underlies the embryonic lethality in the Adar1-/- mouse. The third aim of my thesis was to determine if the lack of inosine modification within cellular RNA was triggering the aberrant immune response in the Adar1-/- mouse. To study this, Adar1-/-; p53 -/- mouse embryonic fibroblasts (MEFs) were generated. By reintroducing various ADAR isoforms into the Adar1-/-; p53 -/- MEFs I found that to rescue the aberrant immune response requires both catalytic activity and the location of an ADAR protein within the cytoplasm. Moreover, I demonstrated that transfecting inosine-containing dsRNA oligonucleotides into Adar1-/-; p53 -/- MEFs suppresses the aberrant immune response. Overall my results suggest that A-to-I editing by ADAR1 is an essential RNA modification that is required by the cell to distinguish between ‘self’ and ‘non-self’ RNA. Editing of cellular RNAs prevents an autoimmune response whereas editing of viral RNA may act to suppress a heightened antiviral immune response and prevent long-term damage to the cell.

Ragone, Frank Leonard. "Identification And Characterization Of The A To I Wobble Deaminase From Trypanosoma Brucei." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1213385124.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Wahlstedt, Helene. "Regulation of site-selective A-to-I RNA editing : During mammalian brain development." Doctoral thesis, Stockholms universitet, Institutionen för molekylärbiologi och funktionsgenomik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-55525.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Adenosine (A) to inosine (I) RNA editing is a widespread post-transcriptional mechanism in mammals that contributes to increase the protein diversity. Adenosine deaminases that act on RNA (ADARs) are the enzymes catalyzing RNA editing. ADARs are particularly active within the brain where they act on transcripts involved in neurotransmission. In this work the editing efficiency of all known site-selectively edited substrates have been analyzed during development of the mouse brain. We show that there is a global regulation of RNA editing, where editing levels of sites increase as the brain matures. This increase in editing efficiency cannot be explained by an increase in ADAR protein expression. During differentiation of primary cells from the mouse brain, editing levels increases similar to what we observe in vivo. Interestingly, the subcellular localization of the ADAR enzymes of cultured neurons show a different distribution in immature compared mature neurons. An accumulation of the ADAR enzymes in the nucleus may explain elevated A-to-I editing during brain development. Furthermore, we find that certain adenosines work as principal sites where editing of the transcript is initiated. Presumably, these sites are kinetically favored and are hypothesized to recruit the ADAR enzymes to the RNA substrate. Editing is then coupled to sites located in multiples of 12 nucleotides from each other. Interestingly, these sites reside on the same side in the 3D helix structure. The Gabra-3 transcript is site-selectively edited at a single position changing an isoleucine codon for a methionine upon editing. Gabra-3 encodes the a3 subunit of the GABAA receptor. We show that receptors assembled with edited a3 are less stable at the cell surface than the non-edited a3. We propose that the amino acid change upon editing, could affect protein interactions important for trafficking and stability of the GABAA receptors. Further, the editing event in a3 may have the function to reduce the number of a3 subunits in favor of other a subunits.
At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Manuscript.

Nigita, Giovanni. "Knowledge bases and stochastic algorithms for mining biological data: applications on A-to-I RNA editing and RNAi." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1555.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Until the second half of twenty century, the connection between Biology and Computer Science was not so strict and the data were usually collected on perishable materials such as paper and then stored up in filing cabinets. This situation changed thanks to the Bioinformatics, a relatively novel field that aims to deal with biological problems by making use of computational approaches. This interdisciplinary science has two particular fields of action: on the one hand, the construction of biological databases in order to store in a rational way the huge amount of data, and, on the other hand, the development and application of algorithms also approximate for extracting predicting patterns from such kind of data. This thesis will present novel results on both of the above aspects. It will introduce three new database called miRandola, miReditar and VIRGO, respectively. All of them have been developed as open sources and equipped with user-friendly web interfaces. Then, some results concerning the application of stochastic approaches on microRNA targeting and RNA A-to-I interference will be introduced.

Du, Yunzhi. "A-to-I pre-mRNA editing of the serotonin 2C receptor /." Connect to full text via ProQuest. IP filtered, 2006.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Thesis (Ph.D. in Human Medical Genetics) -- University of Colorado, 2006.
Typescript. Includes bibliographical references (leaves 118-127). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;

Veneziano, Dario. "Knowledge bases, computational methods and data mining techniques with applications to A-to-I RNA editing, Synthetic Biology and RNA interference." Doctoral thesis, Università di Catania, 2015. http://hdl.handle.net/10761/4085.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

La Bioinformatica, nota anche come Biologia Computazionale, è un campo relativamente nuovo che mira alla risoluzione di problemi biologici attraverso approcci computazionali. Questa scienza interdisciplinare persegue due obiettivi particolari tra i molti: da un lato, la costruzione di database biologici per memorizzare razionalmente sempre maggiori quantità di dati che divengono sempre più disponibili, e, dall'altro, lo sviluppo e l'applicazione di algoritmi al fine di estrarre pattern di predizione ed inferire nuove conoscenze altrimenti impossibili da ottenere da tali dati. Questa tesi presenterà nuovi risultati su entrambi questi aspetti. Infatti, il lavoro di ricerca descritto in questa tesi di dottorato ha avuto come obiettivo lo sviluppo di euristiche e tecniche di data mining per la raccolta e l'analisi di dati relativi ai meccanismi di regolazione post-trascrizionale ed RNA interference, così come il collegamento del fenomeno dell RNA A-to-I editing con la regolazione genica mediate dai miRNA. In particolare, gli sforzi sono stati finalizzati allo sviluppo di una banca dati per la predizione di siti di legame per miRNA editati tramite RNA A-to-I editing; un algoritmo per la progettazione di miRNA sintetici con alta specificità; e una base di conoscenza dotata di algoritmi di data mining per l'annotazione funzionale dei microRNA, proposta come risorsa unificata per la ricerca sui miRNA.

Vogel, Paul [Verfasser], and Thorsten [Akademischer Betreuer] Stafforst. "Establishing Site-Directed A-to-I RNA Editing in Cell Culture / Paul Vogel ; Betreuer: Thorsten Stafforst." Tübingen : Universitätsbibliothek Tübingen, 2019. http://d-nb.info/1193489148/34.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Winner, Katherine M. "A fluorescence-based approach to elucidate the subunit arrangement of the essential tRNA deaminase from Trypanosoma brucei." Wittenberg University Honors Theses / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=wuhonors1617803573189193.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Більше джерел

Книги з теми "A-to-I RNA editing":

Samuel, Charles E. Adenosine deaminases acting on RNA (ADARs) and A-to-I editing. Heidelberg: Springer, 2012.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Samuel, Charles E., ed. Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-22801-8.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Samuel, Charles E. Adenosine Deaminases Acting on RNA and A-to-I Editing. Springer, 2014.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Samuel, Charles E. Adenosine Deaminases Acting on RNA and A-to-I Editing. Springer, 2011.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Частини книг з теми "A-to-I RNA editing":

Sakurai, Masayuki, Shunpei Okada, Hiroki Ueda, and Yuxi Yang. "Discovering A-to-I RNA Editing." In Methods in Molecular Biology, 113–48. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0787-9_8.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Staber, Cynthia J., Selena Gell, James E. C. Jepson, and Robert A. Reenan. "Perturbing A-to-I RNA Editing Using Genetics and Homologous Recombination." In RNA and DNA Editing, 41–73. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-018-8_3.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Sakurai, Masayuki, and Tsutomu Suzuki. "Biochemical Identification of A-to-I RNA Editing Sites by the Inosine Chemical Erasing (ICE) Method." In RNA and DNA Editing, 89–99. Totowa, NJ: Humana Press, 2011. http://dx.doi.org/10.1007/978-1-61779-018-8_5.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Savva, Yiannis A., Georges St Laurent, and Robert A. Reenan. "Genome-Wide Analysis of A-to-I RNA Editing." In Methods in Molecular Biology, 255–68. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3067-8_15.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Schaffer, Amos A., and Erez Y. Levanon. "ALU A-to-I RNA Editing: Millions of Sites and Many Open Questions." In Methods in Molecular Biology, 149–62. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0787-9_9.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Washburn, Michael C., and Heather A. Hundley. "Controlling the Editor: The Many Roles of RNA-Binding Proteins in Regulating A-to-I RNA Editing." In Advances in Experimental Medicine and Biology, 189–213. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29073-7_8.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Galipon, Josephine, Rintaro Ishii, Soh Ishiguro, Yutaka Suzuki, Shinji Kondo, Mariko Okada-Hatakeyama, Masaru Tomita, and Kumiko Ui-Tei. "High-Quality Overlapping Paired-End Reads for the Detection of A-to-I Editing on Small RNA." In Methods in Molecular Biology, 167–83. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8624-8_13.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Eran, Alal, Isaac S. Kohane, and Louis M. Kunkel. "A-to-I RNA Editing in Autism Spectrum Disorder." In Frontiers in Autism Research, 229–48. WORLD SCIENTIFIC, 2014. http://dx.doi.org/10.1142/9789814602167_0010.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Valente, Louis, and Kazuko Nishikura. "ADAR Gene Family and A-to-I RNA Editing: Diverse Roles in Posttranscriptional Gene Regulation." In Progress in Nucleic Acid Research and Molecular Biology, 299–338. Elsevier, 2005. http://dx.doi.org/10.1016/s0079-6603(04)79006-6.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Okada, Shunpei, Masayuki Sakurai, Hiroki Ueda, and Tsutomu Suzuki. "Biochemical and Transcriptome-Wide Identification of A-to-I RNA Editing Sites by ICE-Seq." In Methods in Enzymology, 331–53. Elsevier, 2015. http://dx.doi.org/10.1016/bs.mie.2015.03.014.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Тези доповідей конференцій з теми "A-to-I RNA editing":

Liang, Han. "Abstract 4324: Systematic characterization of A-to-I RNA editing in cancer development." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-4324.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Liang, Han. "Abstract 2411: The role of A-to-I RNA editing in human cancer." In Proceedings: AACR Annual Meeting 2017; April 1-5, 2017; Washington, DC. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.am2017-2411.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Fumagalli, Debora, David Gacquer, Françoise Rothé, Anne Lefort, Frederick Libert, David N. Brown, Naima Kheddoumi, et al. "Abstract S4-02: Principles governing A-to-I RNA editing in breast cancer transcriptome." In Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium; December 9-13, 2014; San Antonio, TX. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.sabcs14-s4-02.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Liang, Han. "Abstract 2661: The genomic landscape and clinical relevance of A-to-I RNA editing in human cancers." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-2661.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Dupont, Floriane, Florian Clatot, David Venet, Véronique Kruys, Debora Fumagalli, Vincent Detours, Françoise Rothé, and Christos Sotiriou. "Abstract 3801: Functional relevance of A-to-I RNA editing on the immune response in breast cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-3801.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Jones, Andrew K. "RNA A-to-I editing broadens the transcriptome and pharmacological diversity of the mosquito RDL GABA receptor." In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.109920.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Liang, Han. "Abstract 4502: The role of A-to-I RNA editing in diversifying the microRNA functions in cancer." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-4502.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Venet, D., F. Rothé, F. Dupont, M. Maetens, D. Fumagalli, R. Salgado, I. Bradbury, et al. "Abstract P2-05-04: Deregulation of A-to-I RNA editing is associated with poor prognosis in HER2+ breast cancers in the neoALTTO trial." In Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.sabcs17-p2-05-04.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Hill, Rodrigo, and Tom Roa. "Place-making: Wānanga based photographic approaches." In LINK 2022. Tuwhera Open Access, 2022. http://dx.doi.org/10.24135/link2022.v3i1.188.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

Ka matakitaki iho au ki te riu o Waikato Ano nei hei kapo kau ake maaku Ki te kapu o taku ringa, The words above are from the poem Māori King Tawhiao wrote expressing his love for his homelands of the Waikato and the region known today as the King Country. The words translate to: “I look down on the valley of Waikato, As though to hold it in the hollow of my hand.” Now imagine a large-scale photograph depicting a close-up frame of cupped hands trying to hold something carefully. The words above inform Professor Tom Roa and Dr. Rodrigo Hill’s current research project titled Te Nehenehenui - The Ancient Enduring Beauty in the Great Forest of the King Country. With this project still in its early stages the research team will present past collaborations which they will show leads into new ideas and discussions about photography, wānanga, and place representation. They focus on Māori King Tawhiao’s finding refuge in Te Nehenehenui, later called the King Country in his honour. He led many of his Waikato people into this refuge as a result of the British Invasion and confiscation of their Waikato lands in the latter part of the nineteenth century. The love of and for those lands prompted him to compose his ‘maioha’ - this poem painting a word-picture of these spaces which their photography humbly aims to portray. The project advances the use of wānanga (forums and meetings through which knowledge is discussed and passed on) and other reflective practices, engaging with mana whenua and providing a thread which will guide the construction of the photographic images. The name Te Nehenhenui was conceptualised by Polynesian ancestors who travelled from Tahiti and were impressed with the beauty of the land and the vast verdant forests of the King Country territories in the North Island of Aotearoa New Zealand. The origins of the name and further relevant historical accounts have been introduced and discussed by Professor Tom Roa (Ngāti Apakura, Ngāti Hinewai), Shane Te Ruki (Ngāti Unu, Ngāti Kahu) and Doug Ruki (Ngāti Te Puta I Te Muri, Ngāti Te Kanawa, Ngāti Peehi) in the TVNZ Waka Huia documentary series. The documentary provides a compelling account of the origins of the name Te Nehenehenui, thus informing this project’s core ideas and objectives. The research fuses wānanga, that is Mātauranga Māori, and photographic research approaches in novel ways. It highlights the importance of local Waikato-Maniapoto cosmological narratives and Māori understandings of place in their intersecting with the Western discipline of photography. This practice-led research focuses on photography and offers innovative forms of critical analysis and academic argumentation by constructing, curating, and presenting the photographic work as a public gallery exhibition. For this edition of the LINK Conference, the research team will present early collaborations and current research developments exploring place-making and wānanga as both methodology and photography practice.

Звіти організацій з теми "A-to-I RNA editing":

Bloch, Guy, Gene E. Robinson, and Mark Band. Functional genomics of reproduction and division of labor in a key non-Apis pollinator. United States Department of Agriculture, January 2011. http://dx.doi.org/10.32747/2011.7699867.bard.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Анотація:

i. List the original objectives, as defined in the approved proposal, and any revisions made at the beginning or during the course of project. Our objectives were: 1) develop state-of-the-art functional genomics tools for B. terrestris. These resources will be then used to: 2) characterize genes and molecular pathways that are associated with reproduction, 3) characterize genes and molecular pathways associated with specialization in foraging or nursing activities, and 4) determine the extent to which juvenile hormone (JH) is involved in the regulation of reproduction and division of labor. 5) Use RNA interference to down regulate genes associated with reproductive physiology, division of labor, or both. A decrease in the cost of RNA sequencing enabled us to further use the BARD support to extend our research to three additional related projects: A) The regulation of body size which is crucial for understanding both reproduction (castedetermination) and (size based) division of labor in bumblebees. B) Analyze RNA editing in our RNA sequencing data which improves the molecular understanding of the systems we study. C) The influence of JH on the fat body in addition to the brain on which we focused in our proposal. The fat body is a key tissue regulating insect reproduction and health. ii. Background to the topic. Bees are by far the most important pollinators in agricultural and natural ecosystems. The recent collapse of honey bee populations, together with declines in wild bee (including bumble bee) populations, puts their vital pollination services under severe threat. A promising strategy for circumventing this risk is the domestication and mass-rearing of non-Apis bees. This approach has been successfully implemented for several bumble bees including Bombusterrestris in Israel, and B. impatiens in the US, which are mass-reared in captivity. In spite of their critical economic and environmental value, little is known about the physiology and molecular biology of bumble bees. In this collaborative project we developed functional genomics tools for the bumble bee B. terrestris and use these tools for a first thorough study on the physiology and molecular biology of reproduction, dominance, and division of labor in a bumble bee. iii. Major conclusions, solutions. The valuable molecular data of this project together with the functional tools and molecular information generated in this BARD funded project significantly advanced the understanding of bumblebee biology which is essential for maintaining their vital pollination services for US and Israel agriculture.