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Статті в журналах з теми "Age dependence of neurogenesis after stroke"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Adamczak, Joanna, Markus Aswendt, Christina Kreutzer, et al. "Neurogenesis upregulation on the healthy hemisphere after stroke enhances compensation for age-dependent decrease of basal neurogenesis." Neurobiology of Disease 99 (December 20, 2016): 47–57. https://doi.org/10.1016/j.nbd.2016.12.015.

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Abstract Stroke is a leading cause of death and disability worldwide with no treatment for the chronic phase available. Interestingly, an endogenous repair program comprising inflammation and neurogenesis is known to modulate stroke outcome. Several studies have shown that neurogenesis decreases with age but the therapeutic importance of endogenous neurogenesis for recovery from cerebral diseases has been indicated as its ablation leads to stroke aggravation and worsened outcome. A detailed characterization of the neurogenic response after stroke related to ageing would help to develop novel a

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2

Pintana, Hiranya, Grazyna Lietzau, Ingrid Lovise Augestad, et al. "Obesity-induced type 2 diabetes impairs neurological recovery after stroke in correlation with decreased neurogenesis and persistent atrophy of parvalbumin-positive interneurons." Clinical Science 133, no. 13 (2019): 1367–86. http://dx.doi.org/10.1042/cs20190180.

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Abstract Type 2 diabetes (T2D) hampers stroke recovery though largely undetermined mechanisms. Few preclinical studies have investigated the effect of genetic/toxin-induced diabetes on long-term stroke recovery. However, the effects of obesity-induced T2D are mostly unknown. We aimed to investigate whether obesity-induced T2D worsens long-term stroke recovery through the impairment of brain’s self-repair mechanisms – stroke-induced neurogenesis and parvalbumin (PV)+ interneurons-mediated neuroplasticity. To mimic obesity-induced T2D in the middle-age, C57bl/6j mice were fed 12 months with high

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3

Kathner-Schaffert, Carolin, Lina Karapetow, Madlen Günther, et al. "Early Stroke Induces Long-Term Impairment of Adult Neurogenesis Accompanied by Hippocampal-Mediated Cognitive Decline." Cells 8, no. 12 (2019): 1654. http://dx.doi.org/10.3390/cells8121654.

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Stroke increases neurogenesis in the adult dentate gyrus in the short term, however, long-term effects at the cellular and functional level are poorly understood. Here we evaluated the impact of an early stroke lesion on neurogenesis and cognitive function of the aging brain. We hypothesized that a stroke disturbs dentate neurogenesis during aging correlate with impaired flexible learning. To address this issue a stroke was induced in 3-month-old C57Bl/6 mice by a middle cerebral artery occlusion (MCAO). To verify long-term changes of adult neurogenesis the thymidine analogue BrdU (5-Bromo-2′-

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4

Adamczak, Joanna, Markus Aswendt, Christina Kreutzer, et al. "Neurogenesis upregulation on the healthy hemisphere after stroke enhances compensation for age-dependent decrease of basal neurogenesis." Neurobiology of Disease 99 (March 2017): 47–57. http://dx.doi.org/10.1016/j.nbd.2016.12.015.

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5

Мякотных, В. С., Е. С. Остапчук, and О. М. Хромцова. "SEXUAL ACTIVITY: DEPENDENCE ON AGE, GENDER, VARIOUS CARDIOVASCULAR DISEASES AND CEREBRAL STROKE." Успехи геронтологии, no. 3 (August 2, 2021): 384–95. http://dx.doi.org/10.34922/ae.2021.34.3.007.

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Целью представленного исследования явилось определение места и роли сексуальных расстройств у представителей разного пола и возраста в развитии фоновой для церебрального инсульта патологии и формировании клинической картины острого периода инсульта и его последствий. Детально рассматривали вопросы интимной жизни 111 пациентов (58 мужчин и 53 женщины) в предшествовавшие инсульту периоды и определяли возможные связи с клиническими особенностями острого периода инсульта. У 77 из этих 111 пациентов изучали динамику сексуальных нарушений в связи с особенностями функционального дефекта, сформировавш

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6

Lieschke, Simone, Bozena Zechmeister, Matteo Haupt, et al. "CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age." Cells 9, no. 1 (2019): 66. http://dx.doi.org/10.3390/cells9010066.

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CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice. The impact of CCL11 on the adult ischemic brain, however, remains elusive. We therefore studied the effect of ectopic CCL11 on both adolescent (six-week) and adult (six-month) C57BL6 mice exposed to stroke. Intraperitoneal application of CCL11 significantly aggravated acute brain injury in adult mice but not in adolescent mice. Likewise, post-stroke neurological recovery after four weeks was significantly

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7

Joundi, Raed A., Gustavo Saposnik, Rosemary Martino, Jiming Fang, and Moira K. Kapral. "Development and Validation of a Prognostic Tool for Direct Enteral Tube Insertion After Acute Stroke." Stroke 51, no. 6 (2020): 1720–26. http://dx.doi.org/10.1161/strokeaha.120.028949.

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Background and Purpose— We aimed to create a novel prognostic risk score to estimate outcomes after direct enteral tube placement in acute stroke. Methods— We used the Ontario Stroke Registry and linked databases to obtain clinical information on all patients with direct enteral tube insertion after ischemic stroke or intracerebral hemorrhage from July 1, 2003 to June 30, 2010 (derivation cohort) and July 1, 2010 to March 31, 2013 (validation cohort). We used multivariable regression to assign scores to predictor variables for 3 outcomes after tube placement: favorable outcome (discharge modif

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8

Baubekov, A. A., T. K. Tajibayev, Ye M. Miyerbekov, et al. "S100B PROTEIN CONTENT IN ISCHEMIC STROKE AND ITS PROGNOSTIC VALUE IN PATIENTS SUBJECTED TO INVASIVE INTERVENTIONS." BULLETIN OF SURGERY IN KAZAKHSTAN, no. 3 (October 1, 2023): 23–28. http://dx.doi.org/10.35805/bsk2023iii004.

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The aim of the study is to determine the levels of the S100B protein in patients with ischemic stroke and evaluate its relationship with the size of brain tissue damage, stroke severity, and clinical outcomes. Materials and methods.The study included 113 patients with acute ischemic stroke, hospitalized within the first day after its onset and subjected to invasive treatment. 101 men and 12 women were examined, including 32 at the age of 50-60, 64 at the age of 61-70, 17 at the age of 71-80. parameters and degree of functional deviations according to the NIHSS scale. Results. The content of S1

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9

Broomfield, Niall, Matthew Walters, and Robert M. West. "Carer strain in post-stroke emotionalism: a cross-sectional analysis." BMJ Open 14, no. 12 (2024): e084079. https://doi.org/10.1136/bmjopen-2024-084079.

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ObjectivesPost-stroke emotionalism (PSE) is a common, under-researched neurologic symptom of stroke, characterised by frequent crying episodes not under usual social control. Currently, there are no data on carer strain in the context of emotionalism after stroke. We aimed to explore the degree of carer strain in carers of individuals with diagnosed PSE compared with carers of individuals with stroke but no PSE to examine whether carer strain varies with particular characteristics of the cared for individual (patient age, sex, social deprivation, stroke type, functional status, mood status) an

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10

Yamaguchi, Susumu, Nobutaka Horie, Katsuya Satoh, et al. "Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke." Journal of Cerebral Blood Flow & Metabolism 38, no. 7 (2017): 1199–212. http://dx.doi.org/10.1177/0271678x17731964.

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Cell transplantation therapy offers great potential to improve impairments after stroke. However, the importance of donor age on therapeutic efficacy is unclear. We investigated the regenerative capacity of transplanted cells focusing on donor age (young vs. old) for ischaemic stroke. The quantities of human mesenchymal stem cell (hMSC) secreted brain-derived neurotrophic factor in vitro and of monocyte chemotactic protein-1 at day 7 in vivo were both significantly higher for young hMSC compared with old hMSC. Male Sprague-Dawley rats subjected to transient middle cerebral artery occlusion tha

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11

Nakamura, Kuniyuki, Kana Ueki, Ryu Matsuo, et al. "Association between decreases in serum uric acid levels and unfavorable outcomes after ischemic stroke: A multicenter hospital-based observational study." PLOS ONE 18, no. 6 (2023): e0287721. http://dx.doi.org/10.1371/journal.pone.0287721.

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Background The association between clinical outcomes in ischemic stroke patients and decreases in serum uric acid levels, which often occur during the acute phase, remains unknown. Herein, we aimed to investigate the association using a large-scale, multicenter stroke registry. Methods We analyzed 4,621 acute ischemic stroke patients enrolled in the Fukuoka Stroke Registry between June 2007 and September 2019 whose uric acid levels were measured at least twice during hospitalization (including on admission). The study outcomes were poor functional outcome (modified Rankin Scale score ≥3) and f

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12

Zartaloudi, Afroditi, Anastasia Papadopoulou, Panagiotis Papadopoulos, Eirini Grammatopoulou, and Anna Kavga. "525 - Anger expression among survivors after stroke in Greek elderly." International Psychogeriatrics 33, S1 (2021): 72. http://dx.doi.org/10.1017/s1041610221002209.

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Introduction:Individuals may consider stroke complications as a threat to their well-being and self- esteem. Anger often occurs in patients after stroke and can disrupt the course of patient’s recovery.The aim of the present study was to investigate anger expression and degree of functionality in patients after stroke. Additionally, the relationship between the above parameters, as well as their correlation with socio-demographic characteristics and clinical factors of these patients were explored.Method:A total of 110 patients after stroke (69 men and 41 women) with a mean age of 69.3 ± 13.7

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13

Fernández-López, David, Niranjana Natarajan, Stephen Ashwal, and Zinaida S. Vexler. "Mechanisms of Perinatal Arterial Ischemic Stroke." Journal of Cerebral Blood Flow & Metabolism 34, no. 6 (2014): 921–32. http://dx.doi.org/10.1038/jcbfm.2014.41.

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The incidence of perinatal stroke is high, similar to that in the elderly, and produces a significant morbidity and severe long-term neurologic and cognitive deficits, including cerebral palsy, epilepsy, neuropsychological impairments, and behavioral disorders. Emerging clinical data and data from experimental models of cerebral ischemia in neonatal rodents have shown that the pathophysiology of perinatal brain damage is multifactorial. These studies have revealed that, far from just being a smaller version of the adult brain, the neonatal brain is unique with a very particular and age-depende

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14

Otieno, Josline Adhiambo, Jenny Häggström, David Darehed, and Marie Eriksson. "Developing machine learning models to predict multi-class functional outcomes and death three months after stroke in Sweden." PLOS ONE 19, no. 5 (2024): e0303287. http://dx.doi.org/10.1371/journal.pone.0303287.

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Globally, stroke is the third-leading cause of mortality and disability combined, and one of the costliest diseases in society. More accurate predictions of stroke outcomes can guide healthcare organizations in allocating appropriate resources to improve care and reduce both the economic and social burden of the disease. We aim to develop and evaluate the performance and explainability of three supervised machine learning models and the traditional multinomial logistic regression (mLR) in predicting functional dependence and death three months after stroke, using routinely-collected data. This

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15

Maksimova, Marina Yu, and Aleksandra S. Airapetova. "Does gender influence the clinical characteristics of ischaemic stroke in patients aged 45–74 years?" Annals of Clinical and Experimental Neurology 15, no. 1 (2021): 32–42. https://doi.org/10.25692/acen.2021.1.4.

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Introduction. Modern studies seek to determine how age and gender affect morbidity and mortality, risk factors, causes, disease severity, and functional brain recovery after ischaemic stroke. The study aimed to investigate the effect of gender on the main clinical characteristics of carotid territory infarction in patients aged 4574 years who did not undergo thrombolysis or mechanical thrombectomy. Materials and methods. We examined 124 patients: 77 (62.1%) men and 47 (37.9%) women of middle age and older, with carotid territory infarction, who were admitted to the Research Center of Neurology

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16

Parlak, Mümüne Merve, Özlem Bizpinar, and Güleser Saylam. "Dysphagia in patients in acute period of ischemic stroke: What is the relationship of dysphagia with infarct localization, cognition, malnutrition, and independence level?" Neurology Asia 27, no. 1 (2021): 63–71. http://dx.doi.org/10.54029/2022kmw.

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Background and Objective: Swallowing and nutritional disorders can occur for many different reasons after stroke. This study aimed to evaluate dysphagia, malnutrition, and independence in patients with an acute period of ischemic stroke, and to examine the relationship between dysphagia and lesion location, cognition, malnutrition, and dependence. Methods: Ischemic stroke patients (n: 109, mean age: 72.91 ± 11.78 year) were evaluated within the first 5 days after stroke. Standardized Mini-Mental State Examination (SMMSE), Combining pulse oximetry with a 10 milliliter (ml) Bedside Water Drinkin

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17

Pikula, Aleksandra, Alexa S. Beiser, Tai C. Chen, et al. "Serum Brain–Derived Neurotrophic Factor and Vascular Endothelial Growth Factor Levels Are Associated With Risk of Stroke and Vascular Brain Injury." Stroke 44, no. 10 (2013): 2768–75. http://dx.doi.org/10.1161/strokeaha.113.001447.

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Background and Purpose— Brain-derived neurotrophic factor (BDNF), a major neurotrophin and vascular endothelial growth factor (VEGF) have a documented role in neurogenesis, angiogenesis, and neuronal survival. In animal experiments, they impact infarct size and functional motor recovery after an ischemic brain lesion. We sought to examine the association of serum BDNF and VEGF with the risk of clinical stroke or subclinical vascular brain injury in a community-based sample. Methods— In 3440 Framingham Study participants (mean age, 65±11 years; 56% women) who were free of stroke/transient ische

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18

Wahyuni, Sri, Christantie Effendy, Fitrina Mahardani Kusumaningrum, and Fatwa Sari Tetra Dewi. "Factors Associated with Independence for Elderly People in Their Activities of Daily Living." Jurnal Berkala Epidemiologi 9, no. 1 (2021): 44. http://dx.doi.org/10.20473/jbe.v9i12021.44-53.

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Background: Health in the elderly does not merely refer to a condition free from disease but should also have elements regarding functionality and independence. Purpose: This study aimed to measure Activities of Daily Living (ADLs) and to identify the factors affecting ADLs among the elderly population in Sleman District. Methods: A cross-sectional study was carried out using secondary data from the Multidimensional Elderly Care project, nested on the Health Demographic and Surveillance System in Sleman, involving 549 elderly participants. The independence of these elderly people was measured

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19

Bergersen, H., A. K. Schanke, and K. S. Sunnerhagen. "Predictors of Emotional Distress and Wellbeing 2–5 Years After Stroke." ISRN Stroke 2013 (March 4, 2013): 1–7. http://dx.doi.org/10.1155/2013/467398.

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Objectives. To identify predictors of emotional distress and psychological wellbeing in stroke survivors 2–5 years after discharge from comprehensive rehabilitation. Material and Methods. The Hospital Anxiety and Depression Scale (HADS), the General Health Questionnaire (GHQ-30), and questions regarding life situations were mailed to former patients. Multiple regression analyses were performed. Results. The responses from 68 participants (37% women), of an average age of 58 years old, were used. Emotional distress (HADS > 10) was identified in 41%. Well-being (GHQ-30 < 6) was identified

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20

Sharpe, Michael, Keith Hawton, Valerie Seagroatt, et al. "Depressive Disorders in Long-Term Survivors of Stroke." British Journal of Psychiatry 164, no. 3 (1994): 380–86. http://dx.doi.org/10.1192/bjp.164.3.380.

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Sixty surviving patients from a community-based stroke register who had computerised tomography (CT) scan evidence of a single brain lesion were interviewed three to five years after their first ever stroke. Depression (DSM–III–R major depression, partially resolved major depression, and dysthymia) was present in 11 (18%) of the patients and was associated with impaired physical and cognitive functioning, greater age, residence in an institution, absence of a close personal relationship, and larger original brain lesion. Of these variables, only functional dependence (odds ratio 16.4; confiden

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21

Al Alawi, Abdullah M., Ikhlas Al Busaidi, Emaad Al Shibli, et al. "Health outcomes after acute ischemic stroke:retrospective and survival analysis from Oman." Annals of Saudi Medicine 42, no. 4 (2022): 269–75. http://dx.doi.org/10.5144/0256-4947.2022.269.

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BACKGROUND: Stroke mortality and related functional disability have been declining over the last two decades, but stroke continues to represent the second leading cause of cardiovascular death worldwide and the number one cause for acquired long-term disability. OBJECTIVES: Assess short- and long-term health outcomes after acute ischemic stroke and analyze factors associated with poor survival and functional outcomes. DESIGN: Retrospective and survival analysis SETTING: Inpatient unit at a tertiary care referral hospital. PATIENTS AND METHODS: All patients admitted with acute ischemic stroke f

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22

Malouin, Francine, Carol L. Richards, and Anne Durand. "Slowing of Motor Imagery after a Right Hemispheric Stroke." Stroke Research and Treatment 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/297217.

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The temporal congruence between real and imagined movements is not always preserved after stroke. We investigated the dependence of temporal incongruence on the side of the hemispheric lesion and its link with working memory deficits. Thirty-seven persons with a chronic stroke after a right or left hemispheric lesion (RHL : n=19; LHL : n=18) and 32 age-matched healthy persons (CTL) were administered a motor imagery questionnaire, mental chronometry and working memory tests. In contrast to persons in the CTL group and LHL subgroup, persons with a RHL had longer movement times during the imagina

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23

Bae, Minwook, Yong-Suk Jeong, Sopheak Phoung, Phoeuk Borei, Dahyeon Koo, and Dougho Park. "The Effects of Carotid Pathologies on Short-Term Functional Outcomes After First-Ever Small Vessel Occlusion Stroke." Brain Sciences 15, no. 7 (2025): 773. https://doi.org/10.3390/brainsci15070773.

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Background: While carotid pathologies are well-established risk factors for stroke, their specific effects on outcomes following stroke that cannot be classified as atherosclerotic remain unclear. In this study, we aimed to determine whether carotid pathologies are associated with functional dependence (FD) 3 months after small vessel occlusion (SVO) stroke. Methods: This retrospective study included patients with a first-ever SVO stroke admitted to a single cerebrovascular-specialty hospital between October 2021 and March 2024. Standardized ultrasound criteria were used to grade the carotid p

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24

Cheren’ko, T. M., and Yu L. Heletyuk. "INFLUENCE OF ARTERIAL HYPERTENSION WITH DIFFERENT DURATION ON NEUROLOGICAL AND FUNCTIONAL OUTCOME OF ISCHEMIC STROKE." Medical Science of Ukraine (MSU) 13, no. 1-2 (2017): 41–48. http://dx.doi.org/10.32345/2664-4738.1-2.2017.06.

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Relevance. The outcome of acute ischemic stroke depends on the complex interaction of many factors, such as those that are not controllable, and those that can be affected. An important prognostic value of blood pressure level during the first day after a stroke has been proven. At the same time, the relationship between the primary ischemic stroke outcome and various characteristics of arterial hypertension (duration, severity of pre-existing arterial hypertension, its course) continues to be studied. Objective: to study the relationship between the degree of neurological recovery and f

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25

Savina, Maria A., Ekaterina V. Ponevezhskaya, Elizaveta A. Petrova, and Eugenia A. Koltsova. "Risk factors for early-onset and late-onset fatigue after a stroke." Neurology Bulletin LV, no. 4 (2024): 25–34. http://dx.doi.org/10.17816/nb227933.

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BACKGROUND. Post-stroke fatigue is a predictor of adverse outcomes such as high mortality, worse functional outcome and daily living dependence. It is a heterogeneous syndrome that changes over time, as demonstrated by studies. AIM. The aim of the study was to assess dynamic changes of risk factors related to post-stroke fatigue during a year after first-ever stroke. MATERIALS AND METHODS. This study formed a section of a prospective observational study involving of a cohort of 348 patients experiencing their first-ever stroke (53.2% male, 46.8% of female, with a mean age of 66±12

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26

Dietert, Kristi, Swetha Mahesula, Pamela Reed, Shane Sprague, Erzsebet Kokovay, and Naomi Sayre. "416 LRP1 as a modulator of hippocampal neurogenesis and neurodegeneration." Journal of Clinical and Translational Science 6, s1 (2022): 81. http://dx.doi.org/10.1017/cts.2022.242.

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OBJECTIVES/GOALS: This project aims to elucidate the mechanism by which LRP1 governs hippocampal neurogenesis with a particular focus on its relevance in brain aging and memory loss. We are specifically interested in further discerning the intricacies of a novel relationship we have discovered between LRP1 and CXCR4 in adult neural stem cells. METHODS/STUDY POPULATION: For the in vivo studies, we are using a triple-transgenic mouse model in which we knockout LRP1 in adult neural stem cells. This is accomplished using a nestin-driven Cre-ER system in animals with floxed LRP1 and a floxed stop c

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Lam, Ka-Hoo, Emma Blom, and Vincent I. H. Kwa. "Predictors of quality of life 1 year after minor stroke or TIA: a prospective single-centre cohort study." BMJ Open 9, no. 11 (2019): e029697. http://dx.doi.org/10.1136/bmjopen-2019-029697.

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ObjectivesIn patients after a transient ischaemic attack (TIA) or minor stroke, dysfunction is often underestimated by clinical measures due to invisible symptoms, including cognitive and emotional problems. Many of these patients need stroke care programme, but others do not. In this study, we aim to identify potential predictors of quality of life (QoL) in patients with TIA or minor stroke 1 year poststroke to be able to select which of these patients will need aftercare.DesignProspective observational cohort study.SettingSingle-centre hospital in the Netherlands.Participants120 patients, di

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Ahamed, Md Saad, Mir Mahfuzul Hoque Chowdhury, Poritosh Kumar Chowdhury, and Md Altaf Hossain. "Evaluation of risk factors associated with stroke." Bangladesh Medical Journal Khulna 48, no. 1-2 (2016): 24–27. http://dx.doi.org/10.3329/bmjk.v48i1-2.27094.

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Stroke is the leading cause of adult disability and is the third commonest cause of death worldwide. It is a major cause of morbidity and mortality with disability and social dependence throughout the world. An observational, descriptive, cross-sectional study was conducted among purposively selected one hundred and seventy patients with stroke admitted at Kushtia Medical College Hospital, Kushtia from July 2014 to June 2015 to evaluate the different modifiable risk factors and their frequency among stroke patients. Stroke patients with more than 24 hours duration presenting within seven days

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Inogés, Marc, Adrià Arboix, Luís García-Eroles, and María José Sánchez-López. "Gender Predicts Differences in Acute Ischemic Cardioembolic Stroke Profile: Emphasis on Woman-Specific Clinical Data and Early Outcome—The Experience of Sagrat Cor Hospital of Barcelona Stroke Registry." Medicina 60, no. 1 (2024): 101. http://dx.doi.org/10.3390/medicina60010101.

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Background and Objectives: Acute ischemic cardioembolic stroke (CS) is a clinical condition with a high risk of death, and can lead to dependence, recurrence, and dementia. Materials and Methods: In this study, we evaluated gender differences and female-specific clinical data and early outcomes in 602 women diagnosed with CS from a total of 4600 consecutive acute stroke patients in a single-center hospital stroke registry over 24 years. A comparative analysis was performed in women and men in terms of demographics, cerebrovascular risk factors, clinical data, and early outcomes. Results: In a

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Blackwood, Jena, Sydney Carpentier, Wei Deng, and Ann Van de Winckel. "Preliminary Rasch analysis of the multidimensional assessment of interoceptive awareness in adults with stroke." PLOS ONE 18, no. 6 (2023): e0286657. http://dx.doi.org/10.1371/journal.pone.0286657.

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Purpose The Multidimensional Assessment of Interoceptive Awareness (MAIA) measures interoceptive body awareness, which includes aspects such as attention regulation, self-regulation, and body listening. Our purpose was to perform a preliminary validation of the MAIA in adults with stroke using Rasch Measurement Theory. Methods The original MAIA has 32 items that measure interoceptive sensibility, which is an aspect of body awareness. We performed a preliminary analysis with Rasch Measurement Theory to evaluate the unidimensionality and structural validity of the scale. We investigated overall

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Yu, Amy Y. X., Laura C. Maclagan, Christina Diong, et al. "Sex Differences in Care Need and Survival in Patients Admitted to Nursing Home Poststroke." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 47, no. 2 (2020): 153–59. http://dx.doi.org/10.1017/cjn.2019.335.

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ABSTRACT:Background:Women are more likely to be admitted to nursing home after stroke than men. Differences in patient characteristics and outcomes by sex after institutionalization are less understood. We examined sex differences in the characteristics and care needs of patients admitted to nursing home following stroke and their subsequent survival.Methods:We identified patients with stroke newly admitted to nursing home between April 2011 and March 2016 in Ontario, Canada, with follow-up until March 2018 using linked administrative data. We calculated prevalence ratios and 95% confidence in

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Cherenko, T. M., and Yu L. Heletyuk. "FUNCTIONAL RECOVERY IN PATIENTS WITH ACUTE ISCHEMIC STROKE AND ITS DEPENDENCE ON THE BLOOD PRESSURE VARIABILITY." Ukrainian Scientific Medical Youth Journal 105, no. 1 (2018): 11–16. http://dx.doi.org/10.32345/usmyj.1(105).2018.11-16.

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Objective - to investigate the association between functional recovery in patients with acute ischemic stroke and arterial hypertension, daily blood pressure (BP) monitoring and its variability. Materials and methods. One hundred fifty patients with initial ischemic stroke and history of arterial hypertension have been examined: 74 (49.3%) women and 76 (50.7%) men with mean age of 67.4±0.7 years. Neurological deficit was evaluated by NIHSS scale, functional outcome – by Barthel index. The diagnosis of hypertension was based on the results of clinical, instrumental examination and medical

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Butsing, Nipaporn, Jaclene A. Zauszniewski, Suebsarn Ruksakulpiwat, Mary T. Quinn Griffin, and Atsadaporn Niyomyart. "Association between post-stroke depression and functional outcomes: A systematic review." PLOS ONE 19, no. 8 (2024): e0309158. http://dx.doi.org/10.1371/journal.pone.0309158.

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Background Post-stroke depression (PSD) is a frequent problem in stroke patients, affecting their rehabilitation process and functional outcomes. Several studies have investigated the relationship between PSD and functional outcomes, but the results have been inconsistent. Objective This systematic review of non-experimental studies aims to investigate the prevalence of post-stroke depression and the association between post-stroke depression and functional outcomes. Method A search of PubMed, MEDLINE, Web of Science, and CINAHL Plus with Full Text was carried out from inception until January

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Różański, Dorota, Stanisław Szlufik, Ryszard Tomasiuk, et al. "Soluble Urokinase Plasminogen Activator Receptor Levels Correlation with Other Inflammatory Factors in Prognosis of Disability and Death in Patients with Ischemic Stroke." Brain Sciences 12, no. 1 (2021): 39. http://dx.doi.org/10.3390/brainsci12010039.

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Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker elevated in cardiovascular diseases. The aim of this 3-year follow-up prospective study was to evaluate suPAR levels in patients with a first ischemic stroke in correlation with CRP, PCT, NT-proCNP and endothelin 1-21 and to investigate the impact of suPAR on the outcome. Fifty-one patients (mean age 73.7+ = 11.9 years, 26 female and 25 male) were included. Samples were collected on the first (suPAR 1), third (suPAR 3) and seventh days after stroke onset (suPAR 7). Plasma samples were analyzed using ELISA. A

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Andreeva, Irina V., and Alexey S. Grigorev. "Correlations and age-related changes in central and peripheral hemodynamic parameters." Digital Diagnostics 4, no. 1S (2023): 9–10. http://dx.doi.org/10.17816/dd430328.

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BACKGROUND: One of the current issues of fundamental and clinical medicine is the early diagnosis of pathological changes that may lead to the development of cardiovascular disease. AIM: The study aimed to investigate age-related changes in the cardiovascular system in healthy individuals by a comprehensive assessment of the correlations between hemodynamic and microcirculatory parameters at different age. METHODS: The study was conducted on 136 adult volunteers with no clinical or laboratory manifestations of cardiovascular disease. The material was divided into five age groups: a

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Pedreira Fonseca, Erika, Maria Brito Alves, Moema Guimarães, Maria Eduarda Carvalho, and Elen Beatriz Pinto. "Clinical and functional characteristics of women after stroke, fallers and non-fallers: a longitudinal study." Revista Pesquisa em Fisioterapia 11, no. 4 (2021): 759–65. http://dx.doi.org/10.17267/2238-2704rpf.v11i4.4150.

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BACKGROUND: Occurrence of falls is among the most frequent complications presented by the elderly and individuals with neurological diseases. It is known that in the elderly, there is a greater frequency of falls in women. However, in individuals after stroke, this relationship is not established. The purpose of this study was to differentiate the clinical and functional characteristics of fallers and non-fallers women after stroke and to verify the association between functional mobility and functional capacity in these women. DESIGN AND SETTING: This is a longitudinal prospective study condu

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Wróblewska, Izabela, Małgorzata Dziechciaż, and Zuzanna Wróblewska. "The Level of Independence Among Seniors with a History of Ischemic Stroke." Journal of Neurological and Neurosurgical Nursing 8, no. 3 (2019): 112–18. http://dx.doi.org/10.15225/pnn.2019.8.3.3.

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Introduction. Stroke is currently among the most dangerous civilization diseases and the most common cause of death and secondary disability in people over 65 years of age. Disease-related disability significantly affects all spheres of human functioning, leading to dependence on third parties’ assistance. One of the most important activities to be undertaken in relation to a disabled patient is diagnosing the level of disability and implementing active efforts for the patient to regain optimal performance and/or accept the disability. Limitation in daily activities is a considerable stress fa

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Villa-García, Lorena, Mercè Salvat-Plana, John Slof, et al. "Care-related quality of life of informal caregivers of stroke survivors: Cross-sectional analysis of a randomized clinical trial." PLOS ONE 19, no. 10 (2024): e0307930. http://dx.doi.org/10.1371/journal.pone.0307930.

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Purpose We aimed to describe the intensity of care and its consequences on informal caregivers of stroke survivors according to the degree of care receivers’ functional dependence for activities of daily living; and to identify the factors associated with caregivers’ care-related quality of life. Methods Cross-sectional analysis of prospective data collected in a cost-utility study alongside the RACECAT trial in Catalonia (Spain). One-hundred and thirty-two care receiver-caregiver pairs were interviewed six months after stroke. Functional dependence for activities of daily living was measured

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Vojtikiv-Samoilovska, Danijela, and Anita Arsovska. "Socio-Demographic Characteristics of the Patients with a Post Stroke Depression from the Municipality of Tetovo, Republic of Macedonia." Open Access Macedonian Journal of Medical Sciences 6, no. 5 (2018): 782–85. http://dx.doi.org/10.3889/oamjms.2018.201.

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BACKGROUND: Although post-stroke depression (PSD) is the most common neuro-psychiatric consequence after a stroke there is still some obscurity regarding its aetiology and risk factors, which complicates its management. A better knowledge of the predictors will enable better prevention and treatment.AIM: The aim of this work was the identification of the risk factors for PSD, typical for the Macedonian population, which will help in early prediction, timely diagnosis and treatment of the disease.MATERIALS AND METHODS: We carried out a prospective study at the Clinical Hospital in Tetovo, the R

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Zerna, Charlotte, Mary P. Lindsay, Jiming Fang, Richard H. Swartz, and Eric E. Smith. "Outcomes in Hospitalized Ischemic Stroke Patients with Dementia on Admission: A Population-Based Cohort Study." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 45, no. 3 (2018): 290–94. http://dx.doi.org/10.1017/cjn.2018.9.

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AbstractBackgroundDementia prevalence is rising, and it will double in the next 20 years. This study sought to understand the prevalence of dementia in hospitalized patients with ischemic stroke, and its impact on outcomes.MethodsUsing the Canadian Institute of Health Information’s (CIHI) Discharge Abstract Database (DAD), all acute ischemic stroke admissions from April 2003 to March 2015 in Canada (excluding Quebec) were analyzed. Concurrent dementia at the time of admission was assessed based on hospital diagnostic codes. Characteristics and in-hospital outcomes were compared in patients wit

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Deng, Wei, Sydney Carpentier, and Ann Van de Winckel. "Physical body experiences questionnaire simplified for active aging (PBE-QAG): Rasch validation." PLOS ONE 18, no. 2 (2023): e0280198. http://dx.doi.org/10.1371/journal.pone.0280198.

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Purpose To validate the Physical Body Experiences Questionnaire simplified for Active aGing (PBE-QAG) with Rasch Measurement Theory. PBE-QAG measures body awareness during physical activity. Methods Community-dwelling adults were recruited at the Minnesota State Fair, Highland Fest, and in the Brain Body Mind Lab (University of Minnesota). They completed demographic, clinical, and behavioral questionnaires and the PBE-QAG, which has 12 items, with scoring options ranging between 0 (totally true) and 4 (totally false). A lower total PBE-QAG score on reflects better body awareness. We validated

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Tistad, Malin, Maria Flink, Charlotte Ytterberg, et al. "Resource use of healthcare services 1 year after stroke: a secondary analysis of a cluster-randomised controlled trial of a client-centred activities of daily living intervention." BMJ Open 8, no. 8 (2018): e022222. http://dx.doi.org/10.1136/bmjopen-2018-022222.

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ObjectiveThe objective of the study was to compare the total use of healthcare services in the course of the first year after a stroke between participants who, after the acute care, had received occupational therapy as a client-centred activities of daily living (ADL) intervention (CADL) and participants who had received usual ADL intervention (UADL).DesignA secondary analysis of a multicentre cluster-randomised controlled trial (RCT).SettingPrimary and secondary care in Sweden.ParticipantsParticipants were included if they: (1) had received CADL or UADL in the RCT, either as inpatients in ge

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Rabiller, Gratianne, Atsushi Kanoke, and Jialing Liu. "Abstract P748: Transcriptome Profiling of the Neural Stem Cell Niche and the Effect of Exercise in Restoring Neurogenesis in Type II Diabetic Mice." Stroke 52, Suppl_1 (2021). http://dx.doi.org/10.1161/str.52.suppl_1.p748.

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Introduction: Previously we found that mice with type 2 diabetes (T2DM) exhibited an accelerated age-associated decline in neurogenesis during baseline and after ischemic stroke compared to age-matched control mice. The current study sought to delineate the transcriptome landscape involved in the impaired neurogenesis and determine if exercise can prevent the deleterious effect of T2DM on neural regeneration. Hypothesis: We hypothesize that T2DM alters signaling pathways regulating neurogenesis and daily exercise mitigates the deleterious effect on neurogenesis in the T2DM mice. Methods: Trans

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Andrade, Karízia Vilanova, Izabel Cristina de Souza, Marianne Maia Dutra Balsells, Adman Câmara Soares Lima, Escolástica Rejane Ferreira Moura, and Priscila de Souza Aquino. "Factors associated with performing activities of daily living in women after suffering a stroke." Revista da Escola de Enfermagem da USP 54 (2020). http://dx.doi.org/10.1590/s1980-220x2018041503560.

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Abstract Objective: To associate sociodemographic variables and risk factors for stroke to the degree of dependence for performing the activities of daily living of women of childbearing age after suffering a stroke. Method: A prospective and analytical longitudinal study conducted in three public hospitals in Fortaleza, CE, Brazil. The Modified Barthel Index was used at the time of attending the unit and 3 months after the stroke to assess the degree of disability in the performance of activities of daily living. The chi-squared and likelihood ratio tests were chosen to analyze the associatio

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Salinas, Joel, Jayandra J. Himali, Jonathan Rosand, Alexa Beiser, Sudha Seshadri, and Erin C. Dunn. "Factors Associated With New-Onset Depression After Stroke." April 1, 2016. https://doi.org/10.1176/appi.neuropsych.15110388.

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To better identify stroke survivors at risk for depression who may benefit from early prevention through targeted strategies in the acute-subacute poststroke period, we examined 118 Framingham Heart Study stroke survivors with longitudinal prestroke depression assessments. Among those who developed poststroke depression, most lacked a history of depressive symptoms 5 years prior to their stroke. Sex (female), advanced age, and prestroke factors (smoking and functional dependence) were associated with new-onset depression poststroke. These findings suggest fully characterizing and accounting fo

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Oliveira, Thaline Moura de, Stela Maris Aguiar Lemos, Antônio Lúcio Teixeira, Marcela Aline Braga, and Aline Mansueto Mourão. "Functional independence, clinical aspects, and sociodemographic factors in patients in the acute phase of stroke: an association analysis." Audiology - Communication Research 29 (2024). http://dx.doi.org/10.1590/2317-6431-2023-2850en.

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ABSTRACT Purpose To analyze the association of functional independence with clinical aspects of neurological impairment, the location and extent of neuronal damage and sociodemographic factors in patients in the acute phase of stroke. Methods Analytical cross-sectional study in 90 adult and older patients affected by ischemic stroke, admitted to the hospital within 24 hours of the vascular event. Sociodemographic factors and clinical aspects data were collected from electronic medical records and/or interviews in order to depict the patients'profile, Oxfordshire Community Stroke Project, Alber

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Yamaguchi, Susumu, Nobtaka Horie, Katsuya Satoh, and Takayuki Matsuo. "Abstract 133: Donor Age Drastically Affects Structural and Functional Recovery After Cell Therapy Following Ischemic Stroke." Stroke 47, suppl_1 (2016). http://dx.doi.org/10.1161/str.47.suppl_1.133.

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Background and purpose: Cell transplantation therapy hold great potential to improve impairments after cerebral ischemia. However, it is still unclear whether donor age affects structural and functional recovery after cell therapy. Here, we investigate the hypothesis that donor age (Young vs. Old) drastically affects the repair mechanism after cell transplantation for ischemic stroke. Methods: Male Sprague Dawley rats were subjected to transient middle cerebral artery occlusion. At 24 hours after stroke, rats were randomly assigned to receive PBS (Control), human mesenchymal stem cells derived

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Chauhan, Anjali, Jacob Hudobenko, Anthony Patrizz, and Louise D. McCullough. "Abstract 65: Restoration of Growth Differentiation Factor 11 Protects Against Stroke in Mice." Stroke 47, suppl_1 (2016). http://dx.doi.org/10.1161/str.47.suppl_1.65.

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Introduction: GDF 11 is a member of the transforming growth factor β superfamily. Loss of GDF11 occurs with aging and declining levels correlate with several detrimental age-associated phenotypes in both peripheral tissues and brain. Restoration of GDF11 enhances neurogenesis and cognitive function in aged mice. Brain expression of GDF11 has not been investigated after stroke. Stroke differentially affects the elderly. In this work we examined the role of GDF11 in aging, stroke and its potential utility as a neuroprotective agent. Methods: Male C57/BL6NCrl young (2-3 months) and aged (19-21) m

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Babaee, Mahsa, Karim Atashgar, Ali Amini Harandi, and Atefeh Yousefi. "Prediction of Stroke after Covid-19 Infection." Basic and Clinical Neuroscience Journal, April 26, 2022, 1–27. http://dx.doi.org/10.32598/bcn.2022.3608.1.

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Background: Although several different studies have been published about COVID-19, ischemic stroke is known yet as a complicated problem for COVID-19 patients. Scientific reports indicate that in many cases, the incidence of stroke in patients with COVID-19 leads to death. Objectives: The obtained mathematical equation in this study can help physicians’ decision-making about treatment and identification of influential clinical factors for early diagnosis. Methods: In this retrospective study, data of 128 patients between March and September 2020 including demographic information, clinical char

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Babaee, Mahsa, Karim Atashgar, Ali Amini Harandi, and Atefeh Yousefi. "Prediction of Stroke after Covid-19 Infection." Basic and Clinical Neuroscience Journal, April 26, 2022, 1–27. http://dx.doi.org/10.32598/bcn.2022.3608.1.

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Background: Although several different studies have been published about COVID-19, ischemic stroke is known yet as a complicated problem for COVID-19 patients. Scientific reports indicate that in many cases, the incidence of stroke in patients with COVID-19 leads to death. Objectives: The obtained mathematical equation in this study can help physicians’ decision-making about treatment and identification of influential clinical factors for early diagnosis. Methods: In this retrospective study, data of 128 patients between March and September 2020 including demographic information, clinical char

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