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1

Bavaasan, Enkhjargal, and Dariimaa Surenjav. "Parkinson's disease risk factors and age." Journal of the Neurological Sciences 429 (October 2021): 119464. http://dx.doi.org/10.1016/j.jns.2021.119464.

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2

Dartigues, J. F., and C. Feart. "Risk factors for Alzheimer disease: Aging beyond age?" Neurology 77, no. 3 (July 13, 2011): 206–7. http://dx.doi.org/10.1212/wnl.0b013e31822550af.

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3

Latorre, Eva, and Lorna W. Harries. "Splicing regulatory factors, ageing and age-related disease." Ageing Research Reviews 36 (July 2017): 165–70. http://dx.doi.org/10.1016/j.arr.2017.04.004.

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4

Son, Ju Hyun, Zee Won Seo, Woosik Choi, Youn-Young Lee, Suk-Woong Kang, and Chang-Hyung Lee. "Etiologic Factors of Rotator Cuff Disease in Elderly: Modifiable Factors in Addition to Known Demographic Factors." International Journal of Environmental Research and Public Health 19, no. 6 (March 21, 2022): 3715. http://dx.doi.org/10.3390/ijerph19063715.

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With the aging society, musculoskeletal degenerative diseases are becoming a burden on society, and rotator cuff disease is one of these degenerative diseases. The purpose of this study was to examine the incidence of shoulder osteoarthritis and the etiologic factors of rotator cuff disease in the Korean elderly population. A total of 102 patients performing ultrasonography were recruited, and their demographic factors were analyzed. As functional factors, visual analog scale and the peak torque of external and internal rotators of the shoulder using an isokinetic dynamometer were measured. As an anatomical factor, the acromiohumeral distance in the plain radiograph of the glenohumeral anterior-posterior view was used. There were more female patients (65.7%) than male patients (34.3%). The age range with the highest number of respondents was 50–59 years old. The mean visual analogue score was 4.09 (Min 1 to Max 9). Age and dominant hand side factors appear to be the crucial etiologic factors of the presence and severity of rotator cuff disease. The lower net value of the external rotator strength is weakly related to the presence of rotator cuff disease after adjusting for age, and this is the only modifiable factor in the study.
5

GEOGHEGAN, J. M., J. FORBES, D. I. CLARK, C. SMITH, and R. HUBBARD. "Dupuytren’s Disease Risk Factors." Journal of Hand Surgery 29, no. 5 (October 2004): 423–26. http://dx.doi.org/10.1016/j.jhsb.2004.06.006.

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Dupuytren’s is a common problem, but little is known about its a etiology. We have undertaken a large case-control study to assess and quantify the relative contributions of diabetes and epilepsy as risk factors for Dupuytren’s in the community. Cases were patients with a diagnosis of Dupuytren’s disease and, for each, two controls were individually matched by age, sex, and general practice. Our dataset included 821 cases and 1,642 controls. Five hundred and eighty-eight (72%) of the cases were men. The mean age at diagnosis was 62 (range 24–97) years. Diabetes was a significant risk factor for Dupuytren’s disease (OR = 1.75) and there was an increased risk for medicinally treated diabetes (metformin – R = 3.56; sulphonylureas – OR = 1.75) and particularly insulin controlled (OR = 4.39) rather than diet-controlled diabetes. Epilepsy (OR = 1.12) and antiepileptic medications were not associated with Dupuytren’s disease. Ascertainment bias in previous studies may explain the reported association with epilepsy.
6

Wanneveich, Mathilde, Hélène Jacqmin-Gadda, Jean-François Dartigues, and Pierre Joly. "Impact of intervention targeting risk factors on chronic disease burden." Statistical Methods in Medical Research 27, no. 2 (March 17, 2016): 414–27. http://dx.doi.org/10.1177/0962280216631360.

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The aging of the population is accompanied by a sharp rise of chronic disease prevalences, such as dementia. These diseases generally cannot be prevented or cured and persist over time, with a progressive deterioration of health, requiring specific care. To reduce the burden of these diseases, it is appropriate to propose interventions targeting disease risk factors, but the association between most of these risk factors and mortality makes it difficult to anticipate the potential impact of such interventions. A method was previously proposed to estimate changes in disease prevalence following an intervention targeting subjects at a given age where the incidence of the disease is supposed to be null. Here, we propose a general framework to make projections for life expectancies with and without the disease, the age at onset, and the lifelong probability of the disease, and to evaluate the consequences of preventive interventions targeting risk factors on these various measures of disease burden. The methodology takes into account the mortality trend over calendar time and age in both healthy and diseased subjects, and the change in mortality due to the intervention. The method is applied to make projections for dementia in 2030 according to several scenarios of public health interventions.
7

Schultz, Clyde. "Age-related Macular Degeneration—Disease, Risk Factors, and Treatments." US Ophthalmic Review 07, no. 02 (2014): 154. http://dx.doi.org/10.17925/usor.2014.07.02.154.

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Age-related macular degeneration (AMD) is a progressive disease of the posterior segment of the eye. It is has been diagnosed worldwide and primarily affects individuals over 50 years of age. The incidence of the disease increases with age and with the presence of certain genetic factors, which may indicate a disposition for disease progression. In addition to genetic factors and age, other factors may be involved in developing AMD. These include obesity and smoking, which are also linked to various cardiovascular conditions. There are two forms of AMD: wet and dry. Both forms may involve the build-up of drusen deposits in the posterior segment of the eye, but the wet form tends to be more severe due to the proliferation of blood vessels into the macula and retinal areas of the back of the eye, thus causing an individual’s vision to become ‘blocked’ or ‘shaded’ usually beginning at the center of the visual field. There are a variety of treatment options for AMD including surgery in the form of laser or photo therapy. The most current treatment options involve the injection of a biologic into the posterior segment of the eye. There are some severe adverse events with this approach but they tend to be rare.
8

Tanna, Nita, Rakesh Srivastava, and Vilpa Tanna. "Age wise distribution of coronary artery disease risk factors." International Journal of Medical Science and Public Health 2, no. 4 (2013): 954. http://dx.doi.org/10.5455/ijmsph.2013.190720131.

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9

Jousilahti, Pekka, Erkki Vartiainen, Jaakko Tuomilehto, and Pekka Puska. "Sex, Age, Cardiovascular Risk Factors, and Coronary Heart Disease." Circulation 99, no. 9 (March 9, 1999): 1165–72. http://dx.doi.org/10.1161/01.cir.99.9.1165.

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10

Gilley, David, Brittney-Shea Herbert, Nazmul Huda, Hiromi Tanaka, and Terry Reed. "Factors impacting human telomere homeostasis and age-related disease." Mechanisms of Ageing and Development 129, no. 1-2 (January 2008): 27–34. http://dx.doi.org/10.1016/j.mad.2007.10.010.

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11

Masters, Colin L. "Major risk factors for Alzheimer's disease: age and genetics." Lancet Neurology 19, no. 6 (June 2020): 475–76. http://dx.doi.org/10.1016/s1474-4422(20)30155-1.

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12

Pauleikhoff, D., M. J. Barondes, D. Minassian, I. H. Chisholm, and A. C. Bird. "Drusen as Risk Factors in Age-Related Macular Disease." American Journal of Ophthalmology 109, no. 1 (January 1990): 38–43. http://dx.doi.org/10.1016/s0002-9394(14)75576-x.

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13

Burns, Alistair, Glyn Lewis, Robin Jacoby, and Raymond Levy. "Factors affecting survival in Alzheimer's disease." Psychological Medicine 21, no. 2 (May 1991): 363–70. http://dx.doi.org/10.1017/s0033291700020468.

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SYNOPSISFactors affecting survival of 178 patients diagnosed using NINCDS/ADRDA criteria for Alzheimer's disease were studied. All patients were drawn from the Camberwell Health Authority Area and so were a representative sample of subjects from a clinical old age psychiatry service. The mortality rate of the sample was 3·5 times that expected after adjustment for age. Younger subjects had a higher standardized mortality ratio than older subjects. The cumulative three-year mortality of the sample was 47%. Factors shown to be associated with a reduced survival included: increasing age, longer duration of illness, male sex, presence of physical illness, poor cognitive function, observed depression and absence of misidentification syndromes. Apraxia was a stronger predictor of early death than aphasia or dysmnesia.
14

Tawse-Smith, Andrew. "Age and oral health: current considerations." Brazilian Oral Research 21, spe (2007): 29–33. http://dx.doi.org/10.1590/s1806-83242007000500006.

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Dental plaque is still considered the main etiological factor for periodontal diseases. Our understanding of periodontal disease has advanced from the previous concepts where gingivitis slowly progressed to periodontitis to a more complex scenario that correlates several risk factors in the pathogenesis of periodontal disease. Among these factors, age has been associated with increased rates of periodontal disease as the population gets older. Although the loss of alveolar bone and periodontal attachment is common in the elderly population, and there is evident age-related changes in the periodontium, severe periodontitis is not a natural consequence of ageing. The importance of identifying the risk factors that participate in the pathogenesis of periodontal disease at an early phase, both of the individual and the disease, as well as evaluating the capacity of the individual to control dental plaque will enable the implementation of an adequate preventive program, where the needs and limitations of the individual are considered to specifically tailor the oral hygiene procedures and the mouthwashes to be used.
15

Zhidkova, Elena A., Sergey V. Shlipakov, Victoria A. Zaborova, Natella I. Krikheli, Oksana M. Drapkina, Ross T. Barnard, and Konstantin G. Gurevich. "Risk Factors for Heart Disease in Working Railwaymen." American Journal of Men's Health 16, no. 6 (November 2022): 155798832211369. http://dx.doi.org/10.1177/15579883221136983.

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Heart diseases are the most common non-communicable diseases worldwide. We examined the prevalence of risk factors for heart disease among a sub-population of working men. In total, 11,059 railway crew workers of the Russian Railways Company were included in the study. We also asked participants to answer several questions based on the WHO STEPwise approach to surveillance (STEPS) translated into Russian. Only 30% of drivers had normal body mass index (BMI), whereas 70% were overweight or obese. In 12% of subjects, total cholesterol was higher than 5 mmol/L. In 15% of participants, glucose level was higher than 5.5 mmol/L. 38% of drivers reported smoking. Physical inactivity was registered in 54% of persons. Only 29% ate according to the key principles of good diet quality. 24% of respondents had a family history of heart disease. MANOVA demonstrated that BMI was determined by age, profession, smoking, physical inactivity, and diet quality. As age increased, the number of people with normal cholesterol levels decreased. It was demonstrated that a correlation existed between glucose levels and BMI. In the total group, the correlation was 0.46 ( p < .05). The correlation between those parameters increased due to age, from 0.33 in the <30 years of age group up to 0.52 in the >50 years of age group. This study demonstrated that there is a high prevalence of risk factors for heart disease in train drivers in the Russian Federation.
16

Mather, Karen A. "Genetic and Environmental Factors in Ageing and Age-Related Disease." Genes 13, no. 3 (February 23, 2022): 396. http://dx.doi.org/10.3390/genes13030396.

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17

Chen, Y., M. Bedell, and K. Zhang. "Age-related Macular Degeneration: Genetic and Environmental Factors of Disease." Molecular Interventions 10, no. 5 (October 1, 2010): 271–81. http://dx.doi.org/10.1124/mi.10.5.4.

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18

Linda, Linda. "THE RISK FACTORS OF HYPERTENSION DISEASE." Jurnal Kesehatan Prima 11, no. 2 (April 10, 2018): 150. http://dx.doi.org/10.32807/jkp.v11i2.9.

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Treatment of inappropriate hypertension will be at risk for complications such as Cerebral Vascular Accident (CVA), heart failure and others. Hypertension at puskesmas Toaya is included in the top 5 most diseases in each year. In the preliminary study found that people with hypertension routine treatment since January-July as many as 152 people. The objective of the research is to know the risk factors of hypertension disease at Community Health Center in Toaya village, Sindue distric, Donggala regency. Descriptive research method, study population is hypertension patients amounted to 152 people. Sample 34 people, sampling purposive sampling. Analysis of squaret chi data. The results showed that the age of hypertensive patients aged ≥ 50 years 20 people (58.8%), age <50 years 5 people (41.2%), male gender was 26 people (76.5%), women 8 23.5% of patients had a history of hypertension of 24 people (70.6%) there was no history of hypertension 10 people (29.4%), obese no 29 people (85.3%) obese 5 people (14, 7%), had a low risk (smoking cigarettes ≤ 10 cigarettes) amounted to 15 people (44.1%), no smoking 9 people (26.5%), low physical activity category was 23 people (67.7%) high category 1 person (2.9%). The conclusion is that the age of hypertensive patients is more ≥ 50 years old, more males, have a history of hypertension, not obesity, hypertensive patients have a lower risk of smoking cigarettes (≤ 10 cigarettes), more low category physical activity. It is suggested to Toaya Puskesmas should do counseling about risk factor and effort of prevention of hypertension and it is recommended to routinely check blood pressure.
19

Calne, Susan, Bruce Schoenberg, Wayne Martin, Ryan J. Uitti, Peter Spencer, and D. B. Calne. "Familial Parkinson's Disease: Possible Role of Environmental Factors." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 14, no. 3 (August 1987): 303–5. http://dx.doi.org/10.1017/s0317167100026664.

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ABSTRACT:We report here six families with Parkinson's disease in whom the onset of symptoms tended to occur at approximately the same time irrespective of the age of the patient. The mean difference in the time of onset in different generations was 4.6 years while the mean difference in age of onset in children and parents was 25.2 years. We construe this pattern of age separation within families as suggestive of an environmental rather than genetic cause. Support for this view derives from the lack of correlation between occurrence of the disease and the degree of consanguinity. We conclude that our findings are in accord with the hypothesis which attributes the cause of some cases of Parkinson's disease to early, subclinical environmental damage followed by age-related attrition of neurons within the central nervous system.
20

Aziz, N. Ahmad, Jorien M. M. van der Burg, Sarah J. Tabrizi, and G. Bernhard Landwehrmeyer. "Overlap between age-at-onset and disease-progression determinants in Huntington disease." Neurology 90, no. 24 (May 9, 2018): e2099-e2106. http://dx.doi.org/10.1212/wnl.0000000000005690.

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ObjectiveA fundamental but still unresolved issue regarding Huntington disease (HD) pathogenesis is whether the factors that determine age at onset are the same as those that govern disease progression. Because elucidation of this issue is crucial for the development as well as optimal timing of administration of novel disease-modifying therapies, we aimed to assess the extent of overlap between age-at-onset and disease-progression determinants in HD.MethodsUsing observational data from Enroll-HD, the largest cohort of patients with HD worldwide, in this study we present, validate, and apply an intuitive method based on linear mixed-effect models to quantify the variability in the rate of disease progression in HD.ResultsA total of 3,411 patients with HD met inclusion criteria. We found that (1) about two-thirds of the rate of functional, motor, and cognitive progression in HD is determined by the same factors that also determine age at onset, with CAG repeat–dependent mechanisms having by far the largest effect; (2) although expanded HTT CAG repeat size had a large influence on average body weight, the rate of weight loss was largely independent of factors that determine age at onset in HD; and (3) about one-third of the factors that determine the rate of functional, motor, and cognitive progression are different from those that govern age at onset and need further elucidation.ConclusionOur findings imply that targeting of CAG repeat–dependent mechanisms, for example through gene-silencing approaches, is likely to affect the rate of functional, motor, and cognitive impairment, but not weight loss, in manifest HD mutation carriers.
21

Ali, Muzaffer. "CORONARY ARTERY DISEASE IN YOUNG PAKISTANIS: RISK FACTORS AND PATTERN OF DISEASE." Pakistan Heart Journal 55, Supplement1 (November 17, 2022): S14. http://dx.doi.org/10.47144/phj.v55isupplement1.2430.

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Objectives: To determine the distribution of risk factors and pattern of coronary artery disease among young Pakistanis presenting with acute coronary artery syndrome. A cross sectional study conducted from August 2018 to October 2019 at Department of Cardiology Jinnah Hospital Lahore. Methodology: Total of 150 young patients up to 40 years of age with acute coronary syndrome (ACS) was included in this study. Risk factors were evaluated on patient’s current medication history for diabetes mellitus, hypertension, lipid lowering drugs and recent reports HbA1c, total body lipids. Data was entered and analyzed in SPSS version 21.0. Socio-demographic, clinical profile and risk factors were evaluated and presented as frequency and percentages. Cross tabulation was for ACS and risk factors. Statistical significance was assessed using Chi-square test with significant value of p < 0.05. Results: Among 150 subjects mean age was 34.20 + 4.246 with minimum age of 23 years and maximum age of 39 years. 92.0 % were male and 56.0% were having acute anterior wall STEMI, 36.0% had acute inferior Wall STEMI, 2.0% suffered from acute lateral wall STEMI, 2.7% had acute inferoposterior wall STEMI and 3.3% had NSTE-ACS. Risk factor analysis shows that 22.0% had diabetes mellitus, 20.7% had hypertension, 33.7% had a positive history of IHD in family, 71.3% were smokers, 44.0% had obesity, 66.0% had reduced HDL and 44.0 % had elevated LDL levels. Regarding pattern of coronary artery disease, 70.7% patients were having one vessel CAD, 28.0% two vessels CAD and 1.3% had three vessels CAD. Conclusion: Mean age of acute coronary syndrome is low amongst young Pakistani population with male predominance and acute anterior and inferior wall STEMI being most frequent diagnosis. Smoking, dyslipidemia particularly low HDL, positive family history of ischemic heart disease, hypertension, diabetes mellitus, obesity, was identified as important risk factors. Most of the patients had one vessel CAD.
22

Pandey, Bandana. "Epidemiology and Risk Factors of Pelvic Inflammatory Disease." Medical Journal of Shree Birendra Hospital 13, no. 1 (July 19, 2015): 4–8. http://dx.doi.org/10.3126/mjsbh.v13i1.12992.

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Introduction: Knowledge of pelvic inflammatory disease and its epidemiology is essential to understand reproductive morbidity in women. This paper estimates the level of association between demographic factors and pelvic inflammatory disease in women in their reproductive age. Methods: A descriptive study done in Humla, Kritipur and Baudha by organizing a health camp. Women of reproductive age group and who have lower abdominal pain, pervaginal discharge, fever, and dysparunia were included in the study after taking informed verbal consent from the patient. Patients who have lower abdominal pain and pervaginal discharge were diagnosed as pelvic inflammatory disease. Results: Diagnoses of pelvic inflammatory disease were made in 30% of attendances amongst women aged between 16 to 48. Increased risk of pelvic inflammatory disease was associated with smoking (P<0.0001), age groups 31 – 40 yrs (44.6%),in rural areas(45%) and people who are illiterate (P<0.0001). Among 400, 383(95%) were reported ever using a modern contraceptive. Conclusion: The prevalence of pelvic inflammatory disease was 30% in reproductive age group and was significantly associated with smoking.doi: http://dx.doi.org/10.3126/mjsbh.v13i1.12992
23

Wald, Nicholas J., Mark Simmonds, and Joan K. Morris. "Screening for Future Cardiovascular Disease Using Age Alone Compared with Multiple Risk Factors and Age." PLoS ONE 6, no. 5 (May 4, 2011): e18742. http://dx.doi.org/10.1371/journal.pone.0018742.

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24

Mudassir, Mujaddid, Javed Iqbal, Muhammad Shafique Arshad, Ali Raza, and Qudsia Anjum Qureshi. "Risk Factors of Premature Coronary Artery Disease." Journal of Rawalpindi Medical College 25, no. 1 (March 30, 2021): 145–50. http://dx.doi.org/10.37939/jrmc.v25i1.1589.

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Introduction: Coronary artery disease (CAD) is one of the commonest and leading causes of death throughout the world. It is becoming common in the younger age group as well. This study was carried out to analyze the risk factors present in young patients who presented with acute Myocardial Infarction (M.I). Materials and Methods: In this descriptive cross-sectional study, we included 120 patients of age 20-35 years of age who presented with the first episode of acute M.I. Study was conducted at Pakistan Institute Of Medical Sciences, Islamabad, department of cardiology for all patients with first MI from 1st February 2016 to 31st January 2018. Twelve risk factors were studied including Gender, Hypertension, Diabetes mellitus, dyslipidemia, sedentary lifestyle, family history of premature CAD, obesity, smoking, dietary habits, profession, socioeconomic stress, drug addictions. The frequency of risk factors was calculated. Results: Results showed that some of the risk factors were present in higher proportion e.g. smoking, sedentary lifestyle, poor dietary habits, and stressful socioeconomic conditions. Most of the patients in the younger age group were drivers. The results of our study showed that male patients were higher(93.3%) in proportion to female patients (6.7%). 33% of patients were drivers, 13% plumbers, 13% shopkeepers, 10% businessmen, 8% laborers, 5% policemen, 5% students, 5% bank officers, 3% engineers, 2% teachers, 1% doctors. 68.3% of patients were smokers. 58.3% of patients were having high-stress scores. 23.3% of patients were having moderate stress score.18.3% were having a low-stress score. 56% of patients were having dyslipidemia.48% of patients were obese. Family history was present in 26.7% of patients. Conclusion: For patients presenting with premature CAD, Some of the modifiable risk factors include hypertension, sedentary lifestyle, fatty dietary habits, obesity, smoking, diabetes, dyslipidemia. The profession also affects the development of IHD as is evident from our study. So primary preventive strategies need to be implied to prevent the development of IHD, especially in individuals who are at risk.
25

Sheladia, Shyam, and P. Hemachandra Reddy. "Age-Related Chronic Diseases and Alzheimer’s Disease in Texas: A Hispanic Focused Study." Journal of Alzheimer's Disease Reports 5, no. 1 (February 24, 2021): 121–33. http://dx.doi.org/10.3233/adr-200277.

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The emergence of age-related chronic diseases within the United States has led to the direct increase of Alzheimer’s disease (AD) as well as other neurological diseases which ultimately contribute to the development of dementia within the general population. To be specific, age-related chronic diseases such as cardiovascular disease, high cholesterol, diabetes, and kidney disease contribute greatly to the advancement and rapid progression of dementia. Furthermore, unmodifiable risk factors such as advancing age and genetics as well as modifiable risk factors such as socioeconomic status, educational attainment, exercise, and diet further contribute to the development of dementia. Current statistics and research show that minority populations such as Hispanic Americans in the United States face the greatest burden of dementia due to the increase in the prevalence of overall population age, predisposing genetics, age-related chronic diseases, low socioeconomic status, as well as poor lifestyle choices and habits. Additionally, Hispanic Americans living within Texas and the rural areas of West Texas face the added challenge of finding appropriate healthcare services. This article will focus upon the research associated with AD as well as the prevalence of AD within the Hispanic American population of Texas and rural West Texas. Furthermore, this article will also discuss the prevalence of age-related chronic diseases, unmodifiable risk factors, and modifiable risk factors which lead to the progression and development of AD within the Hispanic American population of the United States, Texas, and rural West Texas.
26

Matveeva, T. V., M. F. Ismagilov, and S. A. Ishmanova. "Some factors, enfluencing multiple sclerosis (MS)." Neurology Bulletin XXXIV, no. 3-4 (September 15, 2002): 16–20. http://dx.doi.org/10.17816/nb89873.

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Some factors, enfluencing multiple sclerosis development, have been studied. Connection of tire disease with living close to metallurgical plants has been confirmed, as well as with prevailing meat products in food and with craniocerebral trauma. For the first time association of multiple sclerosis with infectionous eye diseases has been revealed, as well us with soft tissue absesses, critical dental caries, with contact with birds and with age of a father (senior than 31 y.o.) at the moment of a patient birth. The factors, determining unfavourable course of MS are: craniocerebral trauma without loss of consciousness, contact with agricultural animals, prevailing meat products in nutrition of persons at the age of untill 15 y.o. and disease beginning with cerebellar symptomatology.
27

Kanwar, Amrinder J., Rahul Mahajan, and Davinder Parsad. "Effect of Age at Onset on Disease Characteristics in Vitiligo." Journal of Cutaneous Medicine and Surgery 17, no. 4 (July 2013): 253–58. http://dx.doi.org/10.2310/7750.2013.12075.

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Background: Vitiligo is a multifactorial disease in which genetic, immunologic, and environmental factors play an important part. Late-onset vitiligo is a poorly defined entity. Materials and Methods: Case records of patients who attended the pigmentary clinic at our institute from January 2001 to December 2010 were reviewed. Patients with a diagnosis of vitiligo were analyzed with respect to their demographic characteristics with special reference to their age at onset. Results: Patients with disease onset after 30 years had a significantly higher association with precipitating factors such as trauma, stress, and drugs in comparison with early-onset vitiligo ( p < .004). However, the difference did not reach statistical significance when these factors were analyzed individually. There was a significantly higher association with other nonautoimmune diseases ( p = .05), a higher incidence of positive family history ( p < .0001), and a higher association with leukotrichia ( p < .002) in late-onset disease. Early-onset nonsegmental vitiligo was associated with a higher incidence of photosensitivity and pruritus compared to early-onset segmental vitiligo. Conclusion: Late-onset vitiligo has certain distinguishing features compared to early-onset vitiligo.
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Alimov, Azamat. "Primary Analysis of the Risk Factors for Severity and Mortality in COVID-19 Patients in Uzbekistan." Journal of Communicable Diseases 53, no. 03 (September 30, 2021): 104–11. http://dx.doi.org/10.24321/0019.5138.202145.

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A retrospective analysis of 561 patients with confirmed COVID-19 was performed to determine the risk factors for severity and mortality which could predict the disease outcome in early stages. Patients were divided into 4 groups in accordance with disease severity: mild, moderate, severe and critical. And initial clinical and laboratory parameters of patients at admission were studied. The age of severe and deceased patients was significantly higher than patients with mild and moderate course (р=0.003). Patiens with severe disease and fatal outcome had higher incidence of concomitant diseases compared to patients with mild and moderate course (p=0.01). The time passed from onset of first symptoms and hospital admission was shorter in patients with mild and moderate disease than patients with severe and critical disease (р=0.0001). The leukocytosis, significant lymphopenia (р=0.0001), high D-dimer and ferritin levels were associated with severe disease. Male gender, old age, presence of concomitant diseases should be considered as risk factors for severe course and death at COVID-19.
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Schmidt, Johanna, Kerstin Landin-Wilhelmsen, Mats Brännström, and Eva Dahlgren. "Cardiovascular Disease and Risk Factors in PCOS Women of Postmenopausal Age." Obstetrical & Gynecological Survey 67, no. 4 (April 2012): 235–36. http://dx.doi.org/10.1097/ogx.0b013e318250224e.

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30

Tershakovec, Andrew M., Abbas F. Jawad, Virginia A. Stallings, Jean A. Cortner, Babette S. Zemel, and Barbara M. Shannon. "Age-related changes in cardiovascular disease risk factors of hypercholesterolemic children." Journal of Pediatrics 132, no. 3 (March 1998): 414–20. http://dx.doi.org/10.1016/s0022-3476(98)70012-5.

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31

Golub, Yulia, Daniela Berg, Donald B. Calne, Ronald F. Pfeiffer, Ryan J. Uitti, A. Jon Stoessl, Zbigniew K. Wszolek, et al. "Genetic factors influencing age at onset in LRRK2-linked Parkinson disease." Parkinsonism & Related Disorders 15, no. 7 (August 2009): 539–41. http://dx.doi.org/10.1016/j.parkreldis.2008.10.008.

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32

Perlstein, Michael A. "Factors Influencing Age at Referral of Children With Congenital Heart Disease." Archives of Pediatrics & Adolescent Medicine 151, no. 9 (September 1, 1997): 892. http://dx.doi.org/10.1001/archpedi.1997.02170460030005.

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33

Tate, Robert B., Jure Manfreda, and T. Edward Cuddy. "The Effect of Age on Risk Factors for Ischemic Heart Disease." Annals of Epidemiology 8, no. 7 (October 1998): 415–21. http://dx.doi.org/10.1016/s1047-2797(98)00011-8.

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34

Klontz, K. C., W. H. Adler, and M. Potter. "Age-dependent resistance factors in the pathogenesis of foodborne infectious disease." Aging Clinical and Experimental Research 9, no. 5 (October 1997): 320–26. http://dx.doi.org/10.1007/bf03339610.

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35

Soto, Ileana, Mark P. Krebs, Alaina M. Reagan, and Gareth R. Howell. "Vascular Inflammation Risk Factors in Retinal Disease." Annual Review of Vision Science 5, no. 1 (September 15, 2019): 99–122. http://dx.doi.org/10.1146/annurev-vision-091517-034416.

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Inflammation of the blood vessels that serve the central nervous system has been increasingly identified as an early and possibly initiating event among neurodegenerative conditions such as Alzheimer's disease and related dementias. However, the causal relevance of vascular inflammation to major retinal degenerative diseases is unresolved. Here, we describe how genetics, aging-associated changes, and environmental factors contribute to vascular inflammation in age-related macular degeneration, diabetic retinopathy, and glaucoma. We highlight the importance of mouse models in studying the underlying mechanisms and possible treatments for these diseases. We conclude that data support vascular inflammation playing a central if not primary role in retinal degenerative diseases, and this association should be a focus of future research.
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Tanner, Caroline M., Biao Chen, Wen-Zhi Wang, Man-Ling Peng, Zho-Lin Liu, Xue-Ling Liang, Li Chiung Kao, David W. Gilley, and Bruce S. Schoenberg. "Environmental Factors in the Etiology of Parkinson's Disease." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 14, S3 (August 1987): 419–23. http://dx.doi.org/10.1017/s0317167100037835.

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ABSTRACT:Parkinson's disease (PD) has been proposed to result from the interaction of aging and environment in susceptible individuals. Defective metabolism of debrisoquine, inherited as an autosomal recessive, has been associated with this susceptibility. In 35 PD patients and 19 age-matched controls, no significant differences in debrisoquine metabolism were found, although a trend to impaired metabolism was noted in patients with disease onset ≤40. Foci of PD patients were associated with rural living and well water drinking, or rural living coupled with market gardening or wood pulp mills. In a questionnaire survey, patients with PD onset ≤age 47 were significantly more likely to have lived in rural areas and to have drunk well water than those with onset ≥age 54 (p≤0.01). Because of population mobility in North America, a case-control study designed to test environmental, occupational, dietary and other proposed risk factors for PD was conducted in China, where the population is more stationary and the environment more stable. No significant differences in incidences of head trauma, smoking or childhood measles were found between patients and controls.
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Vasic, Ljiljana. "Locally advanced non-small cell lung cancer, pretreatment prognostic factors: Disease stage, tumor histopathological characteristics, the patient-related factors." Archive of Oncology 15, no. 1-2 (2007): 19–23. http://dx.doi.org/10.2298/aoo0702019v.

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Background: The existing tumor-node-metastasis staging system ignores numerous clinical, therapeutic, and biological characteristics of lung cancer and psychomotor condition of a patient because it is based on the anatomic extent of disease. Therefore, there is a possibility of inadequate choice of therapy for any individual patient. Based on the disease stage, histopathological characteristics of the tumor and the patient-related factors (sex, age, Karnofsky status, accompanying diseases) the outcome of the disease can be predicted in patients with inoperable and unresectable non-small lung cancer. Methods: This report is a prospective clinical study that included patients with histopathological verified non-small cell lung cancer, followed up for a six-month period, from the beginning of the treatment. The following data were recorded: sex, age, histological cancer type, stage, Karnofsky status, and comorbid diseases. Results: The study showed planocellular carcinoma was more dominant among men than among women and that and at the diagnosis, most patients were in IIIb or IV stage. There was a decrease in psychomotor status of patients. The length of survival depended on Karnofsky index (p= 0.000), comorbidities - chronic myocardiopathy (p= 0.001), diabetes mellitus type 2 (p =0.007), myocardial infraction (p= 0.005), and the stage of the disease (p= 0.001) Conclusion: Psychomotor status of a patient, comborid diseases, and the stage of disease are the factors that determine patient?s tolerance to oncology treatment.
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Hadzi-Pesic, Marina, Jelisaveta Todorovic, and Kristina Brajovic-Car. "Psychological factors and coronary heart disease." Psihologija 40, no. 3 (2007): 463–76. http://dx.doi.org/10.2298/psi0703461h.

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Coronary heart disease (CAD) results from an interaction of different somatic, environmental and behavioral risk factors. Commonly, development of CAD is associated with arterial hypertension, dyslipidemia, diabetes mellitus, smoking, sedentary life style and the like. Psychological factors in their own sake or in combination with other risk factors are also important for genesis of CAD. In this study, 170 people that were diagnosed with CAD and 170 healthy controls of corresponding sex and age were compared for anxiety, aggressiveness and Eysenck's two personality dimension. The data indicate that patients with CAD have very low level of anxiety and aggressiveness and very high level of neuroticism relative to the controls. .
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Bisciglia, Andrea, Vincenzo Pasceri, Diego Irini, Antonio Varveri, and Giulio Speciale. "Risk Factors for Ischemic Heart Disease." Reviews on Recent Clinical Trials 14, no. 2 (May 31, 2019): 86–94. http://dx.doi.org/10.2174/1574887114666190328125153.

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Background: Several risk factors have been empirically linked to an increased risk of cardiovascular disease. Some of them are therapeutically amenable to modification; while others are not. Modifiable risk factors include physical inactivity, tobacco use, diet, “bad fats” in the blood, hypertension, and being overweight; while non-modifiable risk factors include the patient’s family history, the presence versus absence of diabetes mellitus, and demographic characteristics like age, gender, ethnicity, and socio-economic status. Methods: In this article, we review those risk factors that are both clinically important and amenable to change. Conclusion: To prevent cardiovascular disease, it is important to minimize modifiable risk factors, like LDL cholesterol.
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Shakoori, Irfan Sharif, Fauzia Aslam, Gohar Ashraf, and Hammad Akram. "Understanding chronic disease risk factors and multimorbidity." International Journal Of Community Medicine And Public Health 7, no. 5 (April 24, 2020): 1990. http://dx.doi.org/10.18203/2394-6040.ijcmph20201556.

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Chronic diseases and multimorbidity are becoming an alarming public health problem of this century. Multimorbidity is defined as “having two or more chronic diseases at one time in a person” and a result of complex biological, psychological and social phenomenon. The risks of multimorbidity can be divided into modifiable (behavioral factors) and non-modifiable (age, genetics) factors. Socioeconomic disadvantage and environmental factors can also influence on causation of it. Strategies aligned with primary, secondary and tertiary stages of prevention can help in the prevention of multimorbidity and reduction in complications among diseased. Multimorbidity requires multidimensional programs implemented through multiple stakeholder and policymaker’s collaboration.
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Dermendzhiev, Svetlan, Atanaska Petrova, and Tihomir Dermendzhiev. "Age Characteristics and Concomitant Diseases in Patients with Angioedema." Open Access Macedonian Journal of Medical Sciences 7, no. 3 (February 13, 2019): 369–72. http://dx.doi.org/10.3889/oamjms.2019.121.

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BACKGROUND: Angioneurotic oedema (AE) is an unpredictable and dangerous disease directly threatening the patient's life due to a sudden onset of upper respiratory tract obstruction. The disease is associated with various causes and triggering factors, but little is known about the conditions that accompany AE. AIM: The study aims to determine the age-specificities and the spectrum of concomitant diseases in patients with AE. MATERIAL AND METHODS: The subjects of observation were 88 patients (53 women and 35 men) with angioneurotic oedema who underwent diagnostics and treatment in the Department of Occupational Diseases and Clinical Allergology of University hospital “Saint George”-Plovdiv. RESULTS: The highest level of disease prevalence was found in the age group over 50 years, both in males (45.71%) and females (54.72%). We found that the most often concomitant diseases in our patients with AE are cardiovascular (33%). On second place are the patients with other accompanying conditions outside of the target groups (27.3%). Patients with AE and autoimmune thyroiditis were 14.8%, and those with AE and skeletal-muscle disorders-10.2%. Given the role of hereditary factors in this disease, the profession of the patients is considered insignificant. CONCLUSION: Angioedema occurs in all age groups, but half of the cases are in people over 50 years of age. The most common concomitant diseases in angioedema are cardiovascular diseases.
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Soulissa, Abdul Gani. "A Review of the Factors Associated with Periodontal Disease in the Elderly." Journal of Indonesian Dental Association 3, no. 1 (February 20, 2020): 47. http://dx.doi.org/10.32793/jida.v3i1.448.

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The world’s elderly population is growing faster than other age groups. The World Health Organization states that in 2020, Indonesia’s elderly population will reach 11.34% of the total population, or around 28.8 million people. The increasing number of elderly people can be a challenge for clinicians due to the degenerative changes caused by chronic diseases, treatment of chronic diseases, systemic conditions, and oral health care accessibility. The purpose of this study was to analyze the factors that increase the risk of periodontal disease in the elderly. Over the last few years, a lot of research has focused on identifying the relationship between periodontal disease and systemic disease as well as the link between periodontal disease and aging. Increased age relates directly and proportionally with increased prevalence and severity of periodontal disease. Furthermore, an increase in age causes a decrease in motoric function and an increase in comorbidities and their treatments in the elderly. The aging process causes cementum surface irregularities, inhibition of osteoblast activity, and reduction in the number of fibroblasts. Loss of attachment and alveolar bone resorption was affected by frequent exposure to other risk factors. The risk factors that influence the development of periodontal disease in the elderly include systemic diseases, such as diabetes mellitus and osteoporosis, systemic conditions, such as obesity, metabolic syndrome, and stress, treatment of systemic diseases, and limited access to oral health care. Although the potential link between periodontal disease and systemic disease has been established, the extent of this relationship has not yet been clearly explained. Understanding the factors that influence periodontal disease in the elderly is important because it may provide a better understanding of the treatment. The multiple risk factors that cause periodontal disease in elderly patients require special attention involving multidisciplinary teams.
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Shtandel, Svetlana A., Igor R. Barilyak, Vadim V. Khaziev, and Irina V. Gopkalova. "THYROID GLAND DISEASES AND FACTORS, WHICH IMPACT ON ITS POPULATION PREVALENCE." Ecological genetics 8, no. 1 (March 15, 2010): 42–49. http://dx.doi.org/10.17816/ecogen8142-49.

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As the factors which impact on the population prevalence of nodular goiter, Grave’s disease and thyroid gland cancer, iodine deficiency, remote consequences of accident on the Chernobyl atomic station, population age structure and selection in modern conditions were studied. Differential fertility indexes, diseases prevalence and population age structure official statistic data were analyzed. It has been shown, that iodine deficiency expressiveness, consequences of accident on the Chernobyl atomic station, population age structure and selection are impact on the nodular goiter, Grave’s disease and thyroid gland cancer population prevalence.
44

Vanamala, V. G., Sushil Pakyanadhan, Aruna Rachel, and Sudeep Abraham P. "Pelvic inflammatory disease and the risk factors." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, no. 9 (August 27, 2018): 3572. http://dx.doi.org/10.18203/2320-1770.ijrcog20183373.

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Background: Pelvic inflammatory disease is one of the most common gynecological disorders of women. It is a clinical condition where in the endometrial, fallopian tubes and the adjacent pelvic structures are infected due to the ascending infection from the lower genital tract such as vagina and cervix through the uterine cavity leading to severe morbidity.Methods: 150 non-pregnant women who came in with clinical symptoms suggestive of Pelvic inflammatory disease and diagnosed as acute pelvic infection or PID were included in the study. Demographic details such as age, weight, height, parity, socio-economic status, education levels etc were noted.Results: 54% of them belonged to 26-30 years age group, followed by 19.3% of women between 20-25 years. 35.3% of the patients were illiterate followed by primary school education in 29.3%. 74% of the patients belonged to the lower class while 24.7% were from the middle class. Condoms were the most common contraceptive method used in 32% of the cases, while 27.3% of the patients used intrauterine devices.Conclusions: Proper education must be given regarding the hazards of early marriages lack of hygiene, and to abstain from multiple partners, to the women especially those from the lower socioeconomic strata.
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Reddy, P. Hemachandra. "Role of Mitochondria in Neurodegenerative Diseases: Mitochondria as a Therapeutic Target in Alzheimer's Disease." CNS Spectrums 14, S7 (August 2009): 8–13. http://dx.doi.org/10.1017/s1092852900024901.

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A growing body of evidence suggests that mitochondrial abnormalities are involved in aging and in age-related neurodegenerative diseases as well as cancer, diabetes, and several other diseases known to be affected by mitochondria. Causal factors for most age-related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and Friedrich ataxia (FRDA)—are largely unknown. Genetic defects are reported to cause a small number of neurodegenerative diseases (Slide 1), but cellular, molecular, and pathological mechanisms of disease progression and selective neuronal cell death are not understood fully in these diseases. However, based on several cellular, molecular, and animal model studies of Alzheimer's disease, Parkinson's disease, ALS, FRDA, cancer, and diabetes, aging may play a large role in cell death in these diseases. Age-dependent, mitochondrially-generated reactive oxygen species (ROS) have been identified as important factors responsible for disease progression and cell death, particularly in late-onset diseases, in which genetic mutations are not causal factors.
46

Ish, Pranav. "An Epidemiological Study on Risk Factors of Chronic Obstructive Pulmonary Disease." Epidemiology International 06, no. 01 (March 30, 2021): 15–21. http://dx.doi.org/10.24321/2455.7048.202104.

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Introduction: Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of morbidity and mortality worldwide and is expected to increase in the coming decades due to increasing air pollution. In a country like India, it is a challenge to control the growing incidence of COPD. For this, it is imperative to understand the various risk factors that lead to the development of COPD including smoking and the ever-worsening environmental air pollution levels. Material and Methods: This prospective case-control study was carried out at the out-patient clinic of pulmonary medicine at our tertiary care centre. Clinical severity data, demographic characteristics, smoking history, and particulate matter (PM) 2.5 levels at the residence of the patients were recorded. A total of 182 cases of COPD and 365 controls were taken. Result: COPD was found to be common among males (69.2%), among the factory workers, drivers and roadside vendors and in elderly age groups. COPD was found to be associated with exposure to active and passive smoking (p < 0.05). Exposure to dust, fumes, and smoke at the workplace was significantly more prevalent among the COPD patients (13.2%) than the control group (2.7%). Besides, 61.5% of the COPD patients were residing in the area with PM 2.5 levels > 60μg/m3 which was significantly greater than the controls (44.9%). Conclusion: The main risk factor for COPD is exposure to active and passive tobacco smoking. Other environmental factors such as exposure to dust, fumes at the workplace and home are also associated with COPD. Level of PM 2.5 > 60 μg/m3 is associated with an increased risk of COPD. Thus, the environmental history of residence in Delhi or a city with high AQI is significant in evaluating a COPD patient. It is important to understand the contribution of these risk factors as curbing and curtailing them can help prevent and control the growing burden of COPD.
47

Ish, Pranav. "An Epidemiological Study on Risk Factors of Chronic Obstructive Pulmonary Disease." Epidemiology International 06, no. 01 (March 30, 2021): 15–21. http://dx.doi.org/10.24321/2455.7048.202104.

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Introduction: Chronic Obstructive Pulmonary Disease (COPD) is one of the leading causes of morbidity and mortality worldwide and is expected to increase in the coming decades due to increasing air pollution. In a country like India, it is a challenge to control the growing incidence of COPD. For this, it is imperative to understand the various risk factors that lead to the development of COPD including smoking and the ever-worsening environmental air pollution levels. Material and Methods: This prospective case-control study was carried out at the out-patient clinic of pulmonary medicine at our tertiary care centre. Clinical severity data, demographic characteristics, smoking history, and particulate matter (PM) 2.5 levels at the residence of the patients were recorded. A total of 182 cases of COPD and 365 controls were taken. Result: COPD was found to be common among males (69.2%), among the factory workers, drivers and roadside vendors and in elderly age groups. COPD was found to be associated with exposure to active and passive smoking (p < 0.05). Exposure to dust, fumes, and smoke at the workplace was significantly more prevalent among the COPD patients (13.2%) than the control group (2.7%). Besides, 61.5% of the COPD patients were residing in the area with PM 2.5 levels > 60μg/m3 which was significantly greater than the controls (44.9%). Conclusion: The main risk factor for COPD is exposure to active and passive tobacco smoking. Other environmental factors such as exposure to dust, fumes at the workplace and home are also associated with COPD. Level of PM 2.5 > 60 μg/m3 is associated with an increased risk of COPD. Thus, the environmental history of residence in Delhi or a city with high AQI is significant in evaluating a COPD patient. It is important to understand the contribution of these risk factors as curbing and curtailing them can help prevent and control the growing burden of COPD.
48

Fang, Tuanyu, Leweihua Lin, Qianying Ou, Lu Lin, Huachuan Zhang, Kaining Chen, Huibiao Quan, and Yangli He. "An Investigation on the Risk Factors of Thyroid Diseases in Community Population in Hainan." International Journal of Endocrinology 2022 (July 9, 2022): 1–11. http://dx.doi.org/10.1155/2022/4514538.

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Background. In recent years, the incidence of thyroid diseases has increased significantly, which has seriously affected people's work and life. The purpose of this study was to explore the epidemiological characteristics of thyroid diseases and autoantibodies. Method. According to the principle of overall sampling, resident residents ≥18 years and who will not move within 5 years are randomly selected. A total of 2136 eligible individuals were divided into case and control groups according to whether they have thyroid disease. Finally, the impact of potential risk factors on thyroid diseases was evaluated. Results. The overall prevalence of thyroid disease was 58.3%, and there was a significant difference in the prevalence of thyroid disease between women and men (p = 0.004). Except for the age group ≥70 years, with the increase in age, the prevalence gradually increased (p < 0.05). Participants with positive thyroid autoantibodies (TPOAb or TgAb) had a higher prevalence than participants with negative autoantibodies. The positive rate of autoantibodies in women was higher than that in men (p < 0.05). UIC (p = 0.004) and free thyroid hormone (FT4) (p = 0.001) levels of men were higher than those of women, and the TSH level of women was higher than that of men (p = 0.002). The regression analysis showed that women, older age, and family history of thyroid disease were independent risk factors for thyroid disease. Conclusion. The prevalence of thyroid diseases in Hainan was high. Women are more susceptible to thyroid disease than men, and the prevalence increased with age.
49

GREER, A. L., A. TUITE, and D. N. FISMAN. "Age, influenza pandemics and disease dynamics." Epidemiology and Infection 138, no. 11 (March 22, 2010): 1542–49. http://dx.doi.org/10.1017/s0950268810000579.

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SUMMARYThe world is currently confronting the first influenza pandemic of the 21st century [caused by a novel pandemic influenza A (H1N1) virus]. Earlier pandemics have been characterized by age distributions that are distinct from those observed with seasonal influenza epidemics, with higher attack rates (and correspondingly increased proportionate or relative mortality) in younger individuals. While the genesis of protection against infection in older individuals during a pandemic is uncertain, differential vulnerability to infection by age has important implications for disease dynamics and control, and for choice of optimal vaccination strategies. Age-related vulnerability to infection may explain differences between school- and community-derived estimates of the reproductive number (R) for a newly emerged pandemic strain, and may also help explain the failure of a newly emerged influenza A (H1N1) virus strain to cause a pandemic in 1977. Age-related factors may also help explain variability in attack rates, and the size and impact of influenza epidemics across jurisdictions and between populations. In Canada, such effects have been observed in the apparently increased severity of outbreaks on Indigenous peoples' reserves. The implications of these patterns for vaccine allocation necessitate targeted research to understand age-related vulnerabilities early in an influenza pandemic.
50

Podolskyi, V. V., Y. H. Antypkin, Vl V. Podolskyi, T. R. Umanets, T. M. Kaminska, L. A. Livshits, and S. A. Rudenko. "Medical and social factors of the possibility of spreading coronavirus infection among fertile aged women." REPRODUCTIVE ENDOCRINOLOGY, no. 61 (November 25, 2021): 8–14. http://dx.doi.org/10.18370/2309-4117.2021.61.8-14.

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Research objective: to determine the risk factors for the spread of coronavirus infection among women of fertile age.Materials and methods. Authors analyzed the medical records (case histories and questionnaires) of 60 women of fertile age who were treated for coronavirus disease. After analysis of medical and social factors women were divided into age groups. Analysis of risk factors for coronavirus disease was determined by calculating the odds ratio according to Wald at p < 0.05.Results. Evaluation of the odds ratio of the COVID-19 chances depending on the nature of work of women of different ages showed that with intense work the risk of disease increases 2.5 times in the age group up to 30 years, which also confirms the analysis of previous indicators, that younger women with moderate workloads have more opportunities to attend mass events and crowds. In the structure of extragenital diseases in women with coronavirus disease, the chances of disease increased 2.6 times in those women who had a history of chronic tonsillitis. Among the history of infectious diseases, the chance ratio of coronavirus disease was increased in women over 30 years of age who had pertussis. Such data may indicate a similar mechanism of development of these diseases, because the causative agent of pertussis also penetrates the upper respiratory tract and may be accompanied by neurological symptoms – the appearance of seizures and bronchospasm.Conclusions. The data obtained in this way allow us to separate a narrower cohort of women of fertile age who may develop coronavirus disease. This will further allow developing proposals for a more efficient distribution of vaccines among the female population of Ukraine and reduce the prevalence of coronavirus infection.

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