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Статті в журналах з теми "AGEs-inhibitors"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Ortega-Castro, J., M. Adrover, J. Frau, J. Donoso, and F. Muñoz. "Cu2+ complexes of some AGEs inhibitors." Chemical Physics Letters 475, no. 4-6 (2009): 277–84. http://dx.doi.org/10.1016/j.cplett.2009.05.074.

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2

Abudukadeer, Kuerban* Said Salama Moselhy Yaaser Q. Almulaiky Syed Shoeb Razvi Mohammed Nihal Hasan Khalid Omar Abulnaja Taha A. Kumosani Abdulrahman L.-AL-Malki. "NATURAL COMPOUNDS THAT INHIBIT PROTEIN GLYCATION: A REVIEW FOR RECENT FINDINGS." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4027–42. https://doi.org/10.5281/zenodo.1045214.

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Diabetes Mellitus is a chronic, lifelong disease currently impacting people throughout the world. A fundamental cause of Diabetes Mellitus: Non-enzymatic protein glycosylation (glycation) contributes to a group of metabolic diseases, including diabetes-associated late complications, atherosclerosis, chronic renal failure, Alzheimer’s disease and inflammatory arthritis. It has been hypothesized that inhibition of glycation may prevent the diseases associated with diabetes. Inhibitors of glycation have been explored for several decades, chiefly using in vitro models, which resulted in discovery

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3

Zaki, Muthanna K., Mohammed N. Abed, and Fawaz A. Alassaf. "Antidiabetic Agents and Bone Quality: A Focus on Glycation End Products and Incretin Pathway Modulations." Journal of Bone Metabolism 31, no. 3 (2024): 169–81. http://dx.doi.org/10.11005/jbm.2024.31.3.169.

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Diabetes mellitus is associated with inadequate bone health and quality and heightened susceptibility to fractures, even in patients with normal or elevated bone mineral density. Elevated advanced glycation end-products (AGEs) and a suppressed incretin pathway are among the mechanisms through which diabetes affects the bone. Accordingly, the present review aimed to investigate the effects of antidiabetic medications on bone quality, primarily through AGEs and the incretin pathway. Google Scholar, Cochrane Library, and PubMed were used to examine related studies until February 2024. Antidiabeti

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4

Nabi, Rabia, Sahir Sultan Alvi, Mohd Saeed, Saheem Ahmad, and Mohammad Salman Khan. "Glycation and HMG-CoA Reductase Inhibitors: Implication in Diabetes and Associated Complications." Current Diabetes Reviews 15, no. 3 (2019): 213–23. http://dx.doi.org/10.2174/1573399814666180924113442.

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Introduction: Diabetes Mellitus (DM) acts as an absolute mediator of cardiovascular risk, prompting the prolonged occurrence, size and intricacy of atherosclerotic plaques via enhanced Advanced Glycation Endproducts (AGEs) formation. Moreover, hyperglycemia is associated with enhanced glyco-oxidized and oxidized Low-Density Lipoprotein (LDL) possessing greater atherogenicity and decreased the ability to regulate HMG-CoA reductase (HMG-R). Although aminoguanidine (AG) prevents the AGE-induced protein cross-linking due to its anti-glycation potential, it exerts several unusual pharmaco-toxicolog

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5

S. Rahbar, Bentham Science Publisher, and Bentham Science Publisher J.L. Figarola. "Inhibitors and Breakers of Advanced Glycation Endproducts (AGEs): A Review." Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents 2, no. 2 (2002): 135–61. http://dx.doi.org/10.2174/1568013023358889.

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6

Reddy, V. Prakash. "Oxidative Stress in Health and Disease." Biomedicines 11, no. 11 (2023): 2925. http://dx.doi.org/10.3390/biomedicines11112925.

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Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), reactive nitrogen species (RNS), and other free radical species, contributes to the onset and progression of various diseases, including diabetes, obesity, diabetic nephropathy, diabetic neuropathy, and neurological diseases, such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD). Oxidative stress is also implicated in cardiovascular disease and cancer. Exacerbated oxidative stress leads to the accelerated formation of advanced glycation end p

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7

Thomas, M., J. Baynes, S. Thorpe, and M. Cooper. "The Role of AGEs and AGE Inhibitors in Diabetic Cardiovascular Disease." Current Drug Targets 6, no. 4 (2005): 453–74. http://dx.doi.org/10.2174/1389450054021873.

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8

Furukawa, Masako, Tomohito Gohda, Mitsuo Tanimoto, and Yasuhiko Tomino. "Pathogenesis and Novel Treatment from the Mouse Model of Type 2 Diabetic Nephropathy." Scientific World Journal 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/928197.

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Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide. However, current treatments remain suboptimal. Many factors, such as genetic and nongenetic promoters, hypertension, hyperglycemia, the accumulation of advanced glycation end products (AGEs), dyslipidemia, and albuminuria/proteinuria itself, influence the progression of this disease. It is important to determine the molecular mechanisms and treatment of this disease. The development of diabetes results in the formation of AGEs, oxidative stress, and the activation of the renin-angiotensin-aldosterone system (

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9

Lasker, George F., Jason H. Maley, and Philip J. Kadowitz. "A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction." Advances in Pharmacological Sciences 2010 (2010): 1–10. http://dx.doi.org/10.1155/2010/730861.

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Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic actions of three new potential treatments for ED are discussed in this paper: (1) sGC stimulators/activators, (2) Rho-kinase inhibitors, and (3) sodium nitrite.

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10

Giancarlo, Aldini. "High resolution mass spectrometric strategies for studying AGEs inhibitors and RAGE antagonists." Free Radical Biology and Medicine 65 (September 2013): S15. http://dx.doi.org/10.1016/j.freeradbiomed.2013.08.141.

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11

Terasaki, Michishige, Hironori Yashima, Yusaku Mori, et al. "A Dipeptidyl Peptidase-4 Inhibitor Inhibits Foam Cell Formation of Macrophages in Type 1 Diabetes via Suppression of CD36 and ACAT-1 Expression." International Journal of Molecular Sciences 21, no. 13 (2020): 4811. http://dx.doi.org/10.3390/ijms21134811.

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Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to play a protective role against atherosclerosis in both animal models and patients with type 2 diabetes (T2D). However, since T2D is associated with dyslipidemia, hypertension and insulin resistance, part of which are ameliorated by DPP-4 inhibitors, it remains unclear whether DPP-4 inhibitors could have anti-atherosclerotic properties directly by attenuating the harmful effects of hyperglycemia. Therefore, we examined whether a DPP-4 inhibitor, teneligliptin, could suppress oxidized low-density lipoprotein (ox-LDL) uptake, foam ce

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12

Sri Harsha, Pedapati S. C., and Vera Lavelli. "Use of Grape Pomace Phenolics to Counteract Endogenous and Exogenous Formation of Advanced Glycation End-Products." Nutrients 11, no. 8 (2019): 1917. http://dx.doi.org/10.3390/nu11081917.

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The increase in consumption of “ultra-processed” foods has raised attention because of the possible adverse effects deriving from the Maillard reaction leading to the formation of toxic advanced glycation end-products (AGEs) during food processing. Additionally, the increasing trend and consumption of sugar-added foods and sweetened beverages is related to the endogenous formation of the same toxic compounds. However, ultra-processing in the context of food technology can bring challenges as well as a wealth of opportunities. Indeed, re-processing of grape pomace, a by-product of winemaking, c

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13

Velichkova, Stefaniya, Kenn Foubert, and Luc Pieters. "Natural Products as a Source of Inspiration for Novel Inhibitors of Advanced Glycation Endproducts (AGEs) Formation." Planta Medica 87, no. 10/11 (2021): 780–801. http://dx.doi.org/10.1055/a-1527-7611.

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AbstractProtein glycation, a post-translational modification found in biological systems, is often associated with a core defect in glucose metabolism. In particular, advanced glycation endproducts are complex heterogeneous sugar-derived protein modifications implicated in the progression of pathological conditions such as atherosclerosis, diabetic complications, skin diseases, rheumatism, hypertension, and neurodegenerative diseases. Undoubtedly, there is the need to expand the knowledge about antiglycation agents that can offer a therapeutic approach in preventing and treating health issues

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14

Zheng, Wenge, Huijuan Li, Yuyo Go, Xi Hui (Felicia) Chan, Qing Huang, and Jianxin Wu. "Research Advances on the Damage Mechanism of Skin Glycation and Related Inhibitors." Nutrients 14, no. 21 (2022): 4588. http://dx.doi.org/10.3390/nu14214588.

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Our skin is an organ with the largest contact area between the human body and the external environment. Skin aging is affected directly by both endogenous factors and exogenous factors (e.g., UV exposure). Skin saccharification, a non-enzymatic reaction between proteins, e.g., dermal collagen and naturally occurring reducing sugars, is one of the basic root causes of endogenous skin aging. During the reaction, a series of complicated glycation products produced at different reaction stages and pathways are usually collectively referred to as advanced glycation end products (AGEs). AGEs cause c

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15

Sharma, Anil K., Var R. Sharma, Girish K. Gupta, Ghulam Md Ashraf, and Mohammad A. Kamal. "Advanced Glycation End Products (AGEs), Glutathione and Breast Cancer: Factors, Mechanism and Therapeutic Interventions." Current Drug Metabolism 20, no. 1 (2019): 65–71. http://dx.doi.org/10.2174/1389200219666180912104342.

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Background: Advanced Glycation End products (AGEs) are basically the end result of glycation of proteins and/or lipids in the presence of sugars. Specific cases of hyperglycemia have been reported with increased propensity of generation of AGEs. Many chronic and deadly diseases such as diabetes, cancer and neurodegenerative disorders have been known to be caused as a result of generation of AGEs. The role of glutathione (GSH) metabolism and its intricate association with AGEs have also been well established in breast cancer prognosis and treatment. To understand the etiology, mechanism and pro

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16

Wang, Qiushi, Binlin Song, Shuai Jiang, et al. "Hydrogen Sulfide Prevents Advanced Glycation End-Products Induced Activation of the Epithelial Sodium Channel." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/976848.

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Advanced glycation end-products (AGEs) are complex and heterogeneous compounds implicated in diabetes. Sodium reabsorption through the epithelial sodium channel (ENaC) at the distal nephron plays an important role in diabetic hypertension. Here, we report that H2S antagonizes AGEs-induced ENaC activation in A6 cells. ENaC open probability(PO)in A6 cells was significantly increased by exogenous AGEs and that this AGEs-induced ENaC activity was abolished by NaHS (a donor of H2S) and TEMPOL. Incubating A6 cells with the catalase inhibitor 3-aminotriazole (3-AT) mimicked the effects of AGEs on ENa

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17

Lingohr-Smith, Melissa, Chelsea Deitelzweig, Grace Lin, and Jay Lin. "558 Programmed death (PD)-1 and PD-ligand-1 inhibitors in the treatment of non-small cell lung cancer: a systematic review of their efficacy and safety." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A592. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0558.

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BackgroundTreatment advances have been made in non-small cell lung cancer (NSCLC) with the development and approval of programmed death (PD)-1 and PD-ligand 1 (PD-L1) inhibitors. PD-1 and PD-L1 inhibitors may be used as monotherapies or in combination with other agents and have been shown to improve NSCLC patient outcomes in clinical trials. We conducted a systematic search to compare the efficacy and safety of PD-1/PD-L1 inhibitors in the treatment of NSCLC.MethodsA systematic literature search of PubMed was conducted to identify phase III clinical trials in which the efficacy of PD-1/PD-L1 i

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18

Bekki, Munehisa, Nobuhiro Tahara, Atsuko Tahara, et al. "Switching Dipeptidyl Peptidase-4 Inhibitors to Tofogliflozin, a Selective Inhibitor of Sodium-Glucose Cotransporter 2 Improve Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Type 2 Diabetes: A Pilot Study." Current Vascular Pharmacology 17, no. 4 (2019): 411–20. http://dx.doi.org/10.2174/1570161116666180515154555.

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Background: We have found that anagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4) significantly ameliorates arterial stiffness in Type 2 Diabetes Mellitus (T2DM) patients compared with an equivalent hypoglycaemic agent, glimepiride. However, it remains unclear whether switching DPP-4 inhibitors to tofogliflozin, a selective inhibitor of Sodium-Glucose Cotransporter 2 (SGLT2) improves arterial stiffness in T2DM patients. Methods: Nineteen T2DM patients who had received DPP-4 inhibitors for at least 1 year were enrolled in this study. Clinical parameters and arterial stiffness evaluated by c

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19

Jung, Eunsoo, Su-Bin Park, Woo Kwon Jung, Hyung Rae Kim, and Junghyun Kim. "Antiglycation Activity of Aucubin In Vitro and in Exogenous Methylglyoxal Injected Rats." Molecules 24, no. 20 (2019): 3653. http://dx.doi.org/10.3390/molecules24203653.

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Advanced glycation end products (AGEs) is a causative factor of various chronic diseases, including chronic kidney disease and atherosclerosis. AGE inhibitors, such as aminoguanidine and pyridoxamine, have the therapeutic activities for reversing the increase in AGEs burden. This study evaluated the inhibitory effects of aucubin on the formation of methylglyoxal (MGO)-modified AGEs in vitro. We also determined the potential activity of aucubin in reducing the AGEs burden in the kidney, blood vessel, heart, and retina of exogenously MGO-injected rats. Aucubin inhibited the formation of MGO-modi

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20

Cusick, Marika M., Rebecca L. Tisdale, Glenn M. Chertow, Douglas K. Owens, Jeremy D. Goldhaber-Fiebert, and Joshua A. Salomon. "Populationwide Screening for Chronic Kidney Disease." JAMA Health Forum 5, no. 11 (2024): e243892. http://dx.doi.org/10.1001/jamahealthforum.2024.3892.

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ImportanceSodium-glucose cotransporter-2 (SGLT2) inhibitors have changed clinical management of chronic kidney disease (CKD) and made populationwide screening for CKD a viable strategy. Optimal age of screening initiation has yet to be evaluated.ObjectiveTo compare the clinical benefits, costs, and cost-effectiveness of population-wide CKD screening at different initiation ages and screening frequencies.Design, Setting, and ParticipantsThis cost-effectiveness study used a previously published decision-analytic Markov cohort model that simulated progression of CKD among US adults from age 35 ye

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21

Imprialos, Konstantinos P., Chrysoula Boutari, Konstantinos Stavropoulos, Erasmia Sampani, and Asterios I. Karagiannis. "Renin-Angiotensin System Inhibitors: Do They Have the Same Impact at All Ages?" Journal of Clinical Hypertension 18, no. 8 (2016): 828. http://dx.doi.org/10.1111/jch.12809.

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22

Li, Wen, Qiuping Chen, Chengjie Peng, et al. "Roles of the Receptor for Advanced Glycation End Products and Its Ligands in the Pathogenesis of Alzheimer’s Disease." International Journal of Molecular Sciences 26, no. 1 (2025): 403. https://doi.org/10.3390/ijms26010403.

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The Receptor for Advanced Glycation End Products (RAGE), part of the immunoglobulin superfamily, plays a significant role in various essential functions under both normal and pathological conditions, especially in the progression of Alzheimer’s disease (AD). RAGE engages with several damage-associated molecular patterns (DAMPs), including advanced glycation end products (AGEs), beta-amyloid peptide (Aβ), high mobility group box 1 (HMGB1), and S100 calcium-binding proteins. This interaction impairs the brain’s ability to clear Aβ, resulting in increased Aβ accumulation, neuronal injury, and mit

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23

I. Handayani, Supri, Rahmiati Rahmiati, Lisnawati Rahmadi, Rosmalena Rosmalena, and Vivitri D. Prasasty. "Molecular Docking and Drug-Likeness for the Identification of Inhibitory Action of Acetogenins from Annona muricata as Potential Anticancer against Hypoxia Inducible Factor 1 Alpha." Biomedical and Pharmacology Journal 11, no. 3 (2018): 1301–7. http://dx.doi.org/10.13005/bpj/1492.

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Hypoxia inducible factor 1 alpha (HIF-1α) regulates cell growth and differentiation which is implicated in human cancers. HIF-1α activates its cascade carcinogenesis mechanism in cancer cells. It is well-understood that signaling is initiated by HIF-1α receptor. Overexpression of HIF-1α is associated with several different human cancers, including breast cancer, lung cancer and colon cancer. Thus, HIF-1α becomes potential target of therapeutic approach in developing HIF-1α inhibitors. The aim of this research is to investigate potential inhibitors which are known as Acetogenins (AGEs) isolated

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24

Srimachai, Tussanee, and Kiattisak Rattanadilok Na Phuket. "Influence of Inhibitors from Microwave Pretreatment of Oil Palm Frond Pulping (OPFP) on Bioethanol Production." ASEAN Journal of Scientific and Technological Reports 27, no. 1 (2023): 1–14. http://dx.doi.org/10.55164/ajstr.v27i1.249524.

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This research aims to analyze the influence of inhibitors from microwave pretreatment of oil palm frond pulping (OPFP) on the efficiency of bioethanol fermentation by S.cerevisiae in the simultaneous saccharification and fermentation (SSF) processes. OPFPs were achieved at different ages: 3-4, 4-7, 7-10, 10-20, and 20-25 years old. OPFP was pretreated with a microwave and sulfuric acid (MW/SF), microwave and hydrogen sulfide (MW/HP), and microwave and water (MW/W). The results showed that the main inhibitors formed during the pretreatment process of OPFP were acetic acid, furfural, 5-hydroxyme

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25

Pazdro, Robert, and John R. Burgess. "The Antioxidant 3H-1,2-Dithiole-3-Thione Potentiates Advanced Glycation End-Product-Induced Oxidative Stress in SH-SY5Y Cells." Experimental Diabetes Research 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/137607.

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Oxidative stress is implicated as a major factor in the development of diabetes complications and is caused in part by advanced glycation end products (AGEs). AGEs ligate to the receptor for AGEs (RAGE), promoting protein kinase C (PKC)-dependent activation of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and superoxide radical generation. While scavenging antioxidants are protective against AGEs, it is unknown if induction of endogenous antioxidant defenses has the same effect. In this study, we confirmed that the compound 3H-1,2-dithiole-3-thione (D3T) increases reduced-state g

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26

Soetikno, Vivian, Wawaimuli Arozal, Melva Louisa, and Rianto Setiabudy. "New Insight into the Molecular Drug Target of Diabetic Nephropathy." International Journal of Endocrinology 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/968681.

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Diabetic nephropathy (DN) lowered quality of life and shortened life expectancy amongst those affected. Evidence indicates interaction between advanced glycation end products (AGEs), activated protein kinase C (PKC) and angiotensin II exacerbate the progression of DN. Inhibitors of angiotensin-converting enzyme (ACEIs), renin angiotensin aldosterone system (RAAS), AGEs, and PKC have been tested for slowing down the progression of DN. The exact molecular drug targets that lead to the amelioration of renal injury in DN are not well understood. This review summarizes the potential therapeutic tar

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27

Li, Jing, and Jian Gu. "Efficacy of immune checkpoint inhibitors in cancer patients of different ages: a meta-analysis." Future Oncology 15, no. 31 (2019): 3633–46. http://dx.doi.org/10.2217/fon-2019-0279.

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Aim: We conducted an up-to-date meta-analysis of randomized controlled trials (RCTs) to compare the immune checkpoint inhibitors (ICIs) in different age groups. Methods: The relevant RCTs in cancer patients receiving ICIs were searched and the systematic evaluation was performed. PubMed, MEDLINE and EMBASE were searched for studies published till January 2019. Results: A total of 27 RCTs included 17,546 patients were available for this meta-analysis. ICIs significantly improved overall survival (OS) and progression-free survival (PFS) in both of the younger (<65 years) and the older cancer

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Kumar Pasupulati, Anil, P. Swathi Chitra, and G. Bhanuprakash Reddy. "Advanced glycation end products mediated cellular and molecular events in the pathology of diabetic nephropathy." Biomolecular Concepts 7, no. 5-6 (2016): 293–309. http://dx.doi.org/10.1515/bmc-2016-0021.

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AbstractDiabetic nephropathy (DN) is a major cause of morbidity and mortality in diabetic patients and a leading cause of end-stage renal disease (ESRD). Degenerative changes such as glomerular hypertrophy, hyperfiltration, widening of basement membranes, tubulointerstitial fibrosis, glomerulosclerosis and podocytopathy manifest in various degrees of proteinuria in DN. One of the key mechanisms implicated in the pathogenesis of DN is non-enzymatic glycation (NEG). NEG is the irreversible attachment of reducing sugars onto free amino groups of proteins by a series of events, which include the f

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Han, Yujin, Yu Ri Woo, Sang Hyun Cho, Jeong Deuk Lee, and Hei Sung Kim. "Itch and Janus Kinase Inhibitors." Acta Dermato-Venereologica 103 (February 15, 2023): adv00869. http://dx.doi.org/10.2340/actadv.v103.5346.

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Itch is a common skin symptom, with complex aetiology and pathogenesis. It is mediated by 2 pathways, the histaminergic and non-histaminergic pathways. Chronic itch is understood to be processed by the latter and is difficult to treat with traditional pruritus therapies. The Janus kinase and signal transducer and activator of transcription pathway is a signalling mechanism that regulates gene expression through various cytokines. Janus kinase inhibitors, which have been tested and used for several autoimmune diseases, have also been shown to be effective for itch through clinical trials and ca

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Plemmenos, Grigorios, and Christina Piperi. "Pathogenic Molecular Mechanisms in Periodontitis and Peri-Implantitis: Role of Advanced Glycation End Products." Life 12, no. 2 (2022): 218. http://dx.doi.org/10.3390/life12020218.

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Advanced Glycation End Products (AGEs), the products of the non-enzymatic oxidation of proteins, nucleic acids, and lipids, are accumulated in periodontal tissues under hyperglycemic conditions such as Diabetes Mellitus (DM) and are responsible for sustained periodontal destruction. AGEs mediate their intracellular effects either directly or indirectly through receptor binding (via RAGE) in all types of periodontal ligament cells (osteocytes, gingival fibroblasts, stem cells, epithelial cells), indicating an important target for intervention. In combination with lipopolysaccharides (LPS) from

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31

Huo, Shengqi, Qian Wang, Wei Shi, et al. "ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury." International Journal of Molecular Sciences 24, no. 2 (2023): 1667. http://dx.doi.org/10.3390/ijms24021667.

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Cuproptosis resulting from copper (Cu) overload has not yet been investigated in diabetic cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent hyperglycemia play an essential role in cardiotoxicity. To clarify whether cuproptosis was involved in AGEs-induced cardiotoxicity, we analyzed the toxicity of AGEs and copper in AC16 cardiomyocytes and in STZ-induced or db/db-diabetic mouse models. The results showed that copper ionophore elesclomol induced cuproptosis in cardiomyocytes. It was only rescued by copper chelator tetrathiomolybdate rather than by other cel

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Welsh, Christopher, Moshe Yair Kasirer, Jingyi Pan, Yulia Shifrin, and Jaques Belik. "Pantoprazole decreases gastroesophageal muscle tone in newborn rats via rho-kinase inhibition." American Journal of Physiology-Gastrointestinal and Liver Physiology 307, no. 3 (2014): G390—G396. http://dx.doi.org/10.1152/ajpgi.00005.2014.

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Proton pump inhibitors reduce gastric acid secretion and are commonly utilized in the management of gastroesophageal reflux disease across all ages. Yet a decrease in lower esophageal sphincter tone has been reported in vitro in rats through an unknown mechanism; however, their effect on the gastroesophageal muscle tone early in life was never studied. Hypothesizing that proton pump inhibitors also reduce gastroesophageal muscle contraction in newborn and juvenile rats, we evaluated the in vitro effect of pantoprazole on gastric and lower esophageal sphincter muscle tissue. Electrical field st

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Tobias, Joseph D. "Sugammadex: Applications in Pediatric Critical Care." Journal of Pediatric Intensive Care 09, no. 03 (2020): 162–71. http://dx.doi.org/10.1055/s-0040-1705133.

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AbstractSugammadex is a novel pharmacologic agent, which reverses neuromuscular blockade with a mechanism that differs from acetylcholinesterase inhibitors such as neostigmine. There is a growing body of literature demonstrating its efficacy in pediatric patients of all ages. Prospective trials have demonstrated a more rapid and more complete reversal of rocuronium-induced neuromuscular blockade than the acetylcholinesterase inhibitor, neostigmine. Unlike the acetylcholinesterase inhibitors, sugammadex effectively reverses intense or complete neuromuscular blockade. It may also be effective in

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34

Yamagishi, Sho-ichi, Kazuo Nakamura, Takanori Matsui, So Ueda, Yoshihiro Noda, and Tsutomu Imaizumi. "Inhibitors of Advanced Glycation End Products (AGEs): Potential Utility for the Treatment of Cardiovascular Disease." Cardiovascular Drug Reviews 26, no. 1 (2008): 50–58. http://dx.doi.org/10.1111/j.1527-3466.2007.00038.x.

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35

Ahmed, Fadia Thamir, and Shatha Hussien Ali. "AGE-RAGE Pathway as a Potential Therapeutic Target." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 9, no. 1 (2025): 54–62. https://doi.org/10.54133/ajms.v9i1.2108.

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The advanced glycation end products (AGEs) are created by reactions involving a nonenzymatic glycation of lysine or arginine of proteins, and then additional glycoxidation due to oxidative stress occurs. They are part of the secondary stages of traumatic brain injury and the initiation and aggravation of several conditions, such as diabetes mellitus, Alzheimer's disease, and atherosclerosis. The receptor for AGE, also known as the receptor for advanced glycation end product (RAGE), interacts with AGEs and produces intra- and interprotein cross-linkages that deactivate different enzymes and acc

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36

Reddy, V. Prakash, Puspa Aryal, and Emmanuel K. Darkwah. "Advanced Glycation End Products in Health and Disease." Microorganisms 10, no. 9 (2022): 1848. http://dx.doi.org/10.3390/microorganisms10091848.

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Advanced glycation end products (AGEs), formed through the nonenzymatic reaction of reducing sugars with the side-chain amino groups of lysine or arginine of proteins, followed by further glycoxidation reactions under oxidative stress conditions, are involved in the onset and exacerbation of a variety of diseases, including diabetes, atherosclerosis, and Alzheimer’s disease (AD) as well as in the secondary stages of traumatic brain injury (TBI). AGEs, in the form of intra- and interprotein crosslinks, deactivate various enzymes, exacerbating disease progression. The interactions of AGEs with t

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37

Touré, Fatouma, Jean-Marie Zahm, Roselyne Garnotel, et al. "Receptor for advanced glycation end-products (RAGE) modulates neutrophil adhesion and migration on glycoxidated extracellular matrix." Biochemical Journal 416, no. 2 (2008): 255–61. http://dx.doi.org/10.1042/bj20080054.

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AGEs (advanced glycation end-products) accumulate in collagen molecules during uraemia and diabetes, two diseases associated with high susceptibility to bacterial infection. Because neutrophils bind to collagen during their locomotion in extravascular tissue towards the infected area we investigated whether glycoxidation of collagen (AGE-collagen) alters neutrophil migration. Type I collagen extracted from rat tail tendons was used for in vitro glycoxidation (AGE-collagen). Neutrophils were obtained from peripheral blood of healthy adult volunteers and were used for the in vitro study of adhes

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Guo, Jing, Hui Juan Zheng, Wenting Zhang, et al. "Accelerated Kidney Aging in Diabetes Mellitus." Oxidative Medicine and Cellular Longevity 2020 (July 28, 2020): 1–24. http://dx.doi.org/10.1155/2020/1234059.

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With aging, the kidney undergoes inexorable and progressive changes in structural and functional performance. These aging-related alterations are more obvious and serious in diabetes mellitus (DM). Renal accelerated aging under DM conditions is associated with multiple stresses such as accumulation of advanced glycation end products (AGEs), hypertension, oxidative stress, and inflammation. The main hallmarks of cellular senescence in diabetic kidneys include cyclin-dependent kinase inhibitors, telomere shortening, and diabetic nephropathy-associated secretory phenotype. Lysosome-dependent auto

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Yuan, Yang, Lei Zhao, Yaxi Chen, et al. "Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro." American Journal of Physiology-Renal Physiology 301, no. 1 (2011): F236—F243. http://dx.doi.org/10.1152/ajprenal.00646.2010.

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Advanced glycation end products (AGEs) is one of the causative factors of diabetic nephropathy, which is associated with lipid accumulation in glomeruli. This study was designed to investigate whether Nε-(carboxymethyl) lysine (CML; a member of the AGEs family) increases lipid accumulation by impairing the function of sterol-regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) in human mesangial cells (HMCs). Intracellular cholesterol content was assessed by Oil Red O staining and quantitative assay. The expression of molecules controlling cholesterol homeostasis was e

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Khan, Sadiq Noor, Farzana Shaheen, Umair Aleem та ін. "Peptide conjugates of 18β-glycyrrhetinic acid as potent inhibitors of α-glucosidase and AGEs-induced oxidation". European Journal of Pharmaceutical Sciences 168 (січень 2022): 106045. http://dx.doi.org/10.1016/j.ejps.2021.106045.

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Ferchichi, Loubna, Séverine Derbré, Khalid Mahmood, et al. "Bioguided fractionation and isolation of natural inhibitors of advanced glycation end-products (AGEs) from Calophyllum flavoramulum." Phytochemistry 78 (June 2012): 98–106. http://dx.doi.org/10.1016/j.phytochem.2012.02.006.

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42

Ronsisvalle, Simone, Federica Panarello, Giusy Longhitano, Edy Angela Siciliano, Lucia Montenegro, and Annamaria Panico. "Natural Flavones and Flavonols: Relationships among Antioxidant Activity, Glycation, and Metalloproteinase Inhibition." Cosmetics 7, no. 3 (2020): 71. http://dx.doi.org/10.3390/cosmetics7030071.

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Reactive oxygen and nitrogen species as well as advanced glycation endproducts (AGEs) and metalloproteinases (MMPs) play a key role in the development and progression of degenerative processes of body tissues, including skin. Natural antioxidant flavonoids could be beneficial in inhibiting AGEs’ formation and MMPs’ expression. In this study, the antioxidant activity of flavones (luteolin, apigenin, and chrysin) and flavonols (mirycetin, quercetin, and kaempferol) was compared with their inhibitory effects on both metalloproteinases’ (MMP-1, MMP-2, MMP-9, MMP-13) and AGEs’ formation. Comparison

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Du, Hongfei, Tiantian Huang, Maomao Zeng, Qingwu Shen, Ye Jiao, and Wei Quan. "Inhibitory Effects of Some Hydrocolloids on the Formation of Advanced Glycation End Products and Heterocyclic Amines in Chemical Models and Grilled Beef Patties." Polymers 15, no. 19 (2023): 3914. http://dx.doi.org/10.3390/polym15193914.

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Effectively inhibiting the formation of heterocyclic amines (HAs) and advanced glycation end products (AGEs) is crucial to human health. In the present study, chemical model systems were used to evaluate the inhibitory effects of seven hydrocolloids on HA and AGE formation. The results showed that hydrocolloids effectively inhibited the formation of two major AGEs. However, their inhibitory action against HA formation showed unexpected results, wherein alginic acid, carrageenan and konjac glucomannan promoted the formation of 2-Amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP), harmane, no

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44

Perez Gutierrez, Rosa Martha. "Inhibition of Advanced Glycation End-Product Formation byOriganum majoranaL.In Vitroand in Streptozotocin-Induced Diabetic Rats." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–8. http://dx.doi.org/10.1155/2012/598638.

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The development of AGE inhibitors is considered to have therapeutic potential in patients with diabetes diseases. The aim of the present study was investigate the effect of methanolic extract of the leaves ofOriganum majorana(OM) used as spice in many countries on AGEs formation.In vitrostudies indicated a significant inhibitory effects on the formation of AGEs. Their antiglycation activities were not only brought about by their antioxidant activities but also related to their trapping abilities of reactive carbonyl species such as methylglyoxal, an intermediate reactive carbonyl of AGE format

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Kuprash, Liana, Olena Kuprash, and Svetlana Gudarenko. "Metabolic cardiocytoprotectors (trimetazidine and trimethylhydrazine) in geriatrics. Short review." Issue 2 2022, no. 2 2022 (June 7, 2022): 63–70. http://dx.doi.org/10.47855/jal9020-2022-2-5.

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The review presents the clinical studies results of the effectiveness of cardiocytoprotectors, fatty acids synthesis inhibitors, trimetazidine (preductal), and trimethylhydrazine (meldonium, mildronate) in the treatment of cardiovascular disease (angina pectoris, chronic heart failure) and the central nervous system disease (dyscirculatory encephalopathy, chronic cerebral insufficiency, stroke) various ages patients. These data indicate the prospects of using these drugs in the complex therapy of cardiovascular and cerebrovascular diseases in the geriatric clinic. Keywords: metabolic cardiocyt

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Starowicz, Małgorzata, Natalia Płatosz, Natalia Bączek, Dorota Szawara-Nowak, Kristýna Šimková, and Wiesław Wiczkowski. "Unraveling the In Vitro Anti-Advanced Glycation End-Product (Anti-AGE) Potential of Fermented Red Cabbage and Beetroot: Insights into Composition and Activities." Foods 13, no. 12 (2024): 1791. http://dx.doi.org/10.3390/foods13121791.

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This study verified the in vitro activity of red cabbage and beetroot against the formation of advanced glycation end-products (AGEs) and their relationship with the biomolecules’ content. Fermentation of cabbage increased the total phenolic (~10%) and flavonoid contents (~14%), whereas decreased total phenolics/flavonoids in beetroot. Fermented cabbage exhibited higher ability against AGEs, i.e., 17% in the bovine serum albumin–methylglyoxal (BSA-MGO) model and 25% in the BSA–glucose model, while beetroot exhibited 23% and 18%, respectively. The major compounds of cabbage products were cyanid

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Luo, Shao Hua, Yong Wen Huang, An Chen, and Jia Ling Wang. "Domestication and Screening of Saccharomyces Cerevisiae Strain Resistant to Inhibitors in Lignocellulosic Hydrolysates by Acclimatizing Inhibitory." Applied Mechanics and Materials 448-453 (October 2013): 1581–86. http://dx.doi.org/10.4028/www.scientific.net/amm.448-453.1581.

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In order to find the strains which can produce high ethanol yield as well as tolerate inhibitors on the lignocellulosic hydrolysates for developing the renewable bioenergy, the sepecial yeast must be explored. After acclimatizing 23 days and using five different acclimation media with sequential increase in the concentration of inhibitory compounds , a kind ofsaccharomyces cerevisiaestrain resistant to inhibitors was obtained . When the yeast resistant to drug and the parent strain grew in the same media which contained several inhibitory compounds 3.2 g/L acetic acid , 0.8 g/L furfural , 0.4

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Gawalski, Karol, Magdalena Bizoń, Bohdan Dźwigała, Krzysztof Cendrowski, and Włodzimierz Sawicki. "PARP inhibitors – a new direction in the treatment of breast and ovarian cancer." Current Gynecologic Oncology 19, no. 2 (2022): e52-e57. http://dx.doi.org/10.15557/cgo.2021.0009.

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Ovarian cancer, like breast cancer, may either develop spontaneously or as a result of a family history. BRCA1 and BRCA2 mutations significantly increase the risk of both cancers at all ages. It is estimated that 3–5% of women are BRCA mutation carriers. BRCA1 mutation carriers have a 65% risk of breast cancer and 39% risk of ovarian cancer. These risks are lower among BRCA2 mutation carriers, i.e. 45% and 11% for breast and ovarian cancer, respectively. In breast and ovarian cancer with BRCA mutations, blocking the function of poly(ADP-ribose) polymerase (PARP) enzymes, including PARP1 and PA

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Li, Qingxian, Yinxian Wen, Linlong Wang, et al. "Hyperglycemia-induced accumulation of advanced glycosylation end products in fibroblast-like synoviocytes promotes knee osteoarthritis." Experimental & Molecular Medicine 53, no. 11 (2021): 1735–47. http://dx.doi.org/10.1038/s12276-021-00697-6.

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AbstractOsteoarthritis (OA) is significantly associated with diabetes, but how hyperglycemia induces or aggravates OA has not been shown. The synovium plays a critical role in cartilage metabolism and substance exchange. Herein, we intended to investigate whether and how hyperglycemia affects the occurrence and progression of OA by influencing the synovium. In patients with knee OA and diabetes (DM OA), we found a more severe inflammatory response, higher endoplasmic reticulum stress (ERS) levels, and more advanced glycosylation end products (AGEs) accumulation in the synovium than in patients

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Ferrier, Jonathan, Sabrina Djeffal, Holly Porter Morgan, et al. "Antiglycation activity of Vaccinium spp. (Ericaceae) from the Sam Vander Kloet collection for the treatment of type II diabetes1This article is part of a Special Issue entitled “A tribute to Sam Vander Kloet FLS: Pure and applied research from blueberries to heathland ecology”." Botany 90, no. 5 (2012): 401–6. http://dx.doi.org/10.1139/b2012-026.

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In this report, the inhibition of advanced glycation endproducts (AGEs) by extracts of leaves from a collection of six, mainly tropical, Vaccinium L. spp. (Ericaceae) was examined. Indigenous Peoples have used Vaccinium species to treat symptoms of type I and II diabetes. Sustained hyperglycaemia, often associated with diabetes, facilitates crosslinking of sugars with proteins, producing AGEs. AGEs are a therapeutic target since they are responsible for many diabetes symptoms and contribute to ageing and the development of atherosclerosis, kidney, vascular, and neurological diseases. Vaccinium

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