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Дисертації з теми "An agonist of beta-blockers"

Автор: Grafiati

Опубліковано: 7 червня 2025

Оновлено: 2 серпня 2025

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1

Herepath, Michael Leonard. "Agonist-induced sensitivity changes at #beta#-adrenoceptors." Thesis, Cardiff University, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328051.

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2

McCaffrey, Patricia Marion. "Studies of agonist and partial agonist activity at the beta-adrenoceptor in man." Thesis, Queen's University Belfast, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317034.

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3

Manio, Michael Magtoto. "In vivo exposure to lipopolysaccharide unmasks contractions to the alpha2-adrenergic agonist dexmedetomidine in the rat aorta." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208015.

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Dexmedetomidine is α2-adrenergic agent and commonly used in the intensive care setting. It is used primarily to sedate critically ill patients in various surgical, endoscopic and radiologic procedures. This medication gained superiority with other sedatives with a distinct advantage of less depression of the respiratory system. Although dexmedetomidine is often administered to septic patients, the vascular effect has not been fully studied in this clinical setting. In this thesis, rats were administered saline or bacterial lipopolysaccharide (LPS) 1, 10 and 20 mg/kg. Aortic rings were obtai

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4

Tran, Tung Vu. "Ocular Hypotensive Effect of the α2-Adrenergic Agonist, Lofexidine". Thesis, University of North Texas, 1989. https://digital.library.unt.edu/ark:/67531/metadc501156/.

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A selective a2-adrenergic agonist, lofexidine, significantly reduced intraocular pressure (lOP) in intact ocular normotensive NZW rabbits, producing a differential dose-dependent decrease in IOP in'the ipsilateral and contralateral eye. Contralateral IOP reduction was most observable at low doses. Unilateral superior cervical ganglionectomy and extraocular muscle excision studies were undertaken to elucidate the factors influencing differential IOP reduction by lofexidine. Similar significant contralateral decreases in IOP were noted when the agent was applied to either the intact or operated

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5

Santos, Antonio Carlos Ramos dos. "Efeitos do período de administração de cloridrato de zilpaterol e do tempo de confinamento no desempenho, características de carcaça e qualidade de carne de bovinos Nelore." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-16042015-110758/.

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O objetivo desta pesquisa foi avaliar os efeitos do período de administração de cloridrato de zilpaterol (CZ) e do tempo de confinamento no desempenho, características de carcaça, rendimento de cortes cárneos comerciais e na qualidade de carne de bovinos Nelore. Foram utilizados 96 bovinos machos não castrados da raça Nelore, com peso vivo inicial de 377 ± 25,1 kg. O delineamento utilizado foi o de blocos completos casualizados em esquema fatorial 4 × 2, sendo quatro períodos de administração com CZ (0, 20, 30 ou 40 dias) e dois tempos de confinamento (90 ou 117 dias). O período de suplementaç

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6

Parr, Timothy. "Calpain proteinase mRNA and beta-agonist induced muscle growth." Thesis, University of Nottingham, 1991. http://eprints.nottingham.ac.uk/11445/.

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The mechanism by which β-agonists induce skeletal muscle hypertrophy is believed largely to be through a reduction in protein degradation. These growth promoters are also known to effect the activity of the calcium dependent proteinases (calpains) and their specific endogenous inhibitor calpastatin. The changes in activity appear to be toward a decrease in the calpain system's proteolytic potential. In this study attempts were made to determine whether the altered activity of the enzymes and inhibitor were brought about by induced changes in gene expression as reflected by altered levels of sp

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7

Lortie, Michel B. "The rainbow trout muscle beta(2)-adrenoceptor system: Impact of beta(2)-agonist feeding." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6268.

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Previous studies showed that beta2-adrenergic agonists (beta 2-AAs) enhanced muscle growth and reduced lipid deposition in animals of agricultural and economical importance, including teleost fish. The goal of the present study was to provide a mechanistic explanation underlying the reported beta2-AA-induced muscle growth in the rainbow trout (Oncorhynchus mykiss). Using radioligand binding assays and adenylyl cyclase/cAMP assays, this study characterized and demonstrated the presence of functional beta2-adrenoceptors (beta2-ARs) on red and white muscle membranes. Trout fed 40 ppm of two beta2

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8

Nieland, Nick. "Investigations of derivatives of 14#beta#-amino-7,8-dihydromorphinone." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265328.

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9

Arnold, Ian Robert. "In vivo regulation of cardiac beta-adrenoceptors by a partial agonist." Thesis, University of Leicester, 1993. http://hdl.handle.net/2381/35645.

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Chronic therapy with the beta1 selective partial agonist xamoterol is not associated with the tolerance seen with agonists of greater intrinsic activity. In order to investigate whether this could be explained by the effect of xamoterol on the in vivo regulation of cardiac beta-adrenoceptors, 2 studies have been performed. 40 right atrial biopsies were obtained from 55 patients prospectively randomised in a double blind fashion to receive either xamoterol or the beta1 selective antagonist atenolol (previously shown to upregulate beta1-adrenoceptors and enhance beta2 mediated responses) for at

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10

Gangadharan, Denise Michelle. "Thymic development of CS8[alpha][alpha]⁺ TCR[alpha][beta]⁺ agonist selected IEL." Diss., Connected to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2005. http://wwwlib.umi.com/cr/ucsd/fullcit?p3189998.

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Анотація:

Thesis (Ph. D.)--University of California, San Diego, 2005.<br>Title from first page of PDF file (viewed Marc 6, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 100-116).

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11

Van, der Weyde Marlene P. "The effects of the beta-adrenergic agonist, ritodrine, in the fetal lamb." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/30417.

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Ritodrine is a beta-adrenergic agonist commonly used to inhibit premature labor contractions in women. The primary goal of ritodrine tocolysis is to prolong gestation, however, other indications may include fetal distress. The purpose of the current study was to examine the metabolic and behavioral effects of ritodrine in the fetus, using the chronically instrumented pregnant sheep as an experimental model. Ritodrine was infused continuously into 11 fetal lambs at a rate of 2.6 ug/minute for a period of 8, 12 or 24 hours. Samples were taken simultaneously at predetermined time periods from a

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12

Rajab, P. E. "The metabolic, biochemical and cardiovascular effects of treatment with clenbuterol in the rat." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285682.

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13

Sun, Mingwei. "REGULATION OF CIRCADIAN CLOCKS AND METABOLISM BY SYNTHETIC AHR AGONIST BETA-NAPHTHOFLAVONE IN MICE." OpenSIUC, 2016. https://opensiuc.lib.siu.edu/dissertations/1253.

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The circadian clock system is essential for mammals to adapt to environmental conditions such as light-dark cycles and to manage the optimal timing for cyclical physiological processes, including sleep-wakefulness, fasting-feeding and multiple aspects of metabolism. The circadian timing system is arranged in hierarchical fashion, with the master clock in the suprachiasmatic nucleus (SCN) of the hypothalamus, acting as the pace-maker and maintaining synchrony among clocks found in every organ system throughout the body. The core molecular clock consists of two interconnected transcriptional-tra

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14

Wilham, Laura Elizabeth. "The role of [beta]-arrestin in agonist-induced down-regulation of the M₁mAChR." CONNECT TO THIS TITLE ONLINE, 2006. http://etd.lib.umt.edu/theses/available/etd-03022007-104437/.

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15

Schmid, Cullen L. "Differential regulation of serotonin 2A receptor responsiveness by agonist-directed interactions with beta-arrestin2." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1300287547.

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16

Van, Patrick P. T. "Comparison of nebulised vs MDI-spacer delivered beta-2 agonist therapy in patients with asthma in the community." Thesis, The University of Sydney, 2001. https://hdl.handle.net/2123/27750.

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Objective: The aim of this study was to determine whether asthma symptoms and beta-2 agonist usage were any different between community patients using a nebuliser or a metereddose inhaler with a spacer (MDI—spacer) to deliver beta-2 agonist for the relief of symptoms. Design and setting: A randomised intervention versus control group study in a community pharmacy. Participants: 48 patients with asthma over 2 years of age; 34 completed the study. Intervention: Subjects with a repeat prescription for salbutamol nebules were randomised to switch to MDI—spacer with patient counselling and

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17

Oliveira, Simone Raymundo de. "Efeito da adição de ractopamina e da imunocastração na carne in natura de suínos." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/74/74131/tde-18112016-151135/.

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A moderna suinocultura vem nos últimos anos avançando no desenvolvimento e no emprego de tecnologias que visam o aumento da performance produtiva e econômica do segmento. As inovações associadas aos métodos de castração e modificadores metabólicos têm sido avaliadas, em particular o uso da imunocastração e dos repartidores de energia (ractopamina). Embora os ganhos zootécnicos e industriais destas tecnologias já estejam bem discutidos, o real impacto do emprego juntas ou isoladas sobre a qualidade tecnológica da carne pelo seu efeito na matriz bioquímica, necessita de estudos mais aprofundados

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18

Hagenmaier, Jacob Andrew. "Investigation into an ongoing dilemma: undefined welfare implications challenging the use of β-adrenergic agonists in beef production". Diss., Kansas State University, 2016. http://hdl.handle.net/2097/35217.

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Doctor of Philosophy<br>Department of Diagnostic Medicine/Pathobiology<br>Daniel U. Thomson<br>Beta-adrenergic agonists (βAA) are administered during the final weeks of the beef production system to improve efficiency and increase meat yield. Welfare concerns linked to the administration of βAA have garnered significant attention in recent years due to anecdotal reports of increased mortality during βAA feeding periods and cattle without obvious disease or injury having difficulty walking at abattoirs being overrepresented in cattle fed βAA. Thomson et al. (2015) reported 2 events where cattle

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19

Clausen, Lisa. "Effects of beta-2 adrenergic receptor agonists in DOK7 congenital myasthenic syndrome." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:9360c51b-8497-47ca-bd16-e917a3614a25.

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Congenital myasthenic syndromes (CMS) are a rare group of heterogeneous disorders, characterised by compromised neuromuscular transmission and symptoms of fatiguable muscle weakness. CMS is caused by mutations in genes that affect the structure and function of the neuromuscular junction (NMJ). In about 20% of CMS cases, patients have mutations in the gene DOK7; the protein product, DOK7, is crucial for maintaining the dense aggregation of acetylcholine receptor (AChR) clusters at the NMJ. DOK7-CMS patients do not respond to treatment with acetylcholinesterase inhibitors which are the first lin

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20

Van, Bibber-Krueger Cadra. "Use of exogenous growth promotants in finishing cattle." Thesis, Kansas State University, 2014. http://hdl.handle.net/2097/18152.

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Master of Science<br>Department of Animal Sciences and Industry<br>James S. Drouillard<br>Exogenous growth promotants, such as the synthetic beta agonist zilpaterol hydrochloride (ZH), have been shown to increase carcass weight by repartitioning energy toward increased skeletal muscle at the expense of adipose tissue, which is associated with a decline in tenderness. More recently, essential oils such as menthol have been observed to have growth promoting properties in livestock. The objectives of this research were to determine effects of ZH on blood parameters and long chain fatty acids in p

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21

Allamenos, Christodoulos. "Techniques assessing infant lung function and their application in the assessment of response to inhaled #beta#-2 agonist." Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262811.

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22

Jindarat, Sarawut. "The role of TNFa and IFNy on CXCL10 regulation and beta-2 agonist inhibition in human airway smooth muscle cells." Thesis, University of Nottingham, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.537793.

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23

Barden, Timothy John. "The synthesis of novel O-alkyl analogues of the energy-repartitioning [beta]-agonist clenbuterol and their physiological and immunological characterisations." Thesis, [Campbelltown, N.S.W. : The Author], 1995. http://handle.uws.edu.au:8081/1959.7/29572.

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It was proposed that some O-alkyl analogues of the beta-adrenergic agonist clenbuterol would be effective structural and functional congeners of clenbuterol which may then be used for the production of clenbuterol-specific idiotypic antibodies. These antibodies could possibly then be used to generate anti-idiotypic antibodies that mimic the energy-repartitioning effects of clenbuterol. Therefore, the aim of this work was to synthesise and characterise these compounds, evaluate their physiological effects, characterise the specificity of antibodies produced in response to protein conjugates of

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24

Barden, Timothy John. "The synthesis of novel O-alkyl analogues of the energy-repartitioning [beta]-agonist clenbuterol and their physiological and immunological characterisations /." [Campbelltown, N.S.W. : The Author], 1995. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030723.132446/index.html.

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25

Murray, Philip. "cHYD1 Solution Phase Synthesis Optimization and the Development of a Novel Human Growth Hormone Antagonist and Agonist." Scholar Commons, 2012. http://scholarcommons.usf.edu/etd/4179.

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Inhibiting protein-protein interactions to achieve a therapeutically desired effect has been a goal in the field of drug discovery for decades. Recently, advances in peptidomimetics have led researches to the use of cyclized peptides to achieve this goal. Cyclization of linear peptides restricts the number of conformations of the peptide, increasing the peptide's affinity to binding to the desired target. Cyclization also stabilizes the peptide, allowing the peptide to be resistant to proteases. This study explores the optimization of solution phase synthesis of an important integrin-media

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26

Hutchison, Shanna. "Improving the value of cull cows through antemortem management practices and postmortem enhancement technologies." Diss., Manhattan, Kan. : Kansas State University, 2007. http://hdl.handle.net/2097/424.

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27

Morais, Carla Patrícia Amorim Carneiro de. "A atividade do NHE3 em túbulo proximal é inibida pela sinalização enviesada do receptor de angiotensina II tipo 1/beta-arrestina." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-20042016-113857/.

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Os receptores medeiam a maioria das respostas fisiológicas em resposta a diversidade de estímulos. A ativação da sinalização mediada pelo receptor de angiotensina II tipo 1 é o principal responsável pelos efeitos do hormônio angiotensina II (Ang II) nos tecidos alvo. No rim concentrações fisiológicas de Ang II aumentam a atividade no túbulo proximal da isoforma 3 do trocador de Na+/H+ (NHE3). Este efeito é crucial para a manutenção do volume extracelular e pressão arterial. Evidências recentes mostraram que a ativação seletiva da sinalização enviesada da beta-arrestina/ receptor AT1 induz diur

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28

Baxa, Timothy John. "Effect of Zilpaterol hydrochloride and steroid implantation on yearling steer feedlot performance, carcass characteristics, and skeletal muscle gene expression." Thesis, Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/936.

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29

Reyes-Reyes, Elsa M., Irma N. Ramos, Marco A. Tavera-Garcia, and Kenneth S. Ramos. "The aryl hydrocarbon receptor agonist benzo(a)pyrene reactivates LINE-1 in HepG2 cells through canonical TGF-beta 1 signaling: implications in hepatocellular carcinogenesis." E-CENTURY PUBLISHING CORP, 2016. http://hdl.handle.net/10150/621353.

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Long interspersed nuclear element-1 (L1) is a genetic element that mobilizes throughout the mammalian genome via retrotransposition and damages host DNA via mutational insertions, chromosomal rearrangements, and reprogramming of gene expression. The cellular mechanisms responsible for aberrant L1 expression during cancer pathogenesis are unclear. Previously, we have shown that L1 reactivation in several human cell lines is dependent upon the activation of aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor member of the PAS superfamily of proteins. We also showed that ecto

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30

Vaali, Kirsi. "Relaxation mechanisms of nitric oxide donors, b[beta]2-adrenoreceptor agonist and their synergistic effect in vitro in airways smooth muslce : role of potassium channels." Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/vaali/.

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31

Calixto, Jussara Maria Reis. "Ractopamina e arginina na alimentação de suínos." Universidade Jose do Rosario Vellano, 2012. http://tede2.unifenas.br:8080/jspui/handle/jspui/135.

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Анотація:

Made available in DSpace on 2016-05-02T13:55:34Z (GMT). No. of bitstreams: 1 JussaraMaria ReisCalixto-dissertacao.pdf: 678492 bytes, checksum: 69d16272c951188cf230141c93f2978b (MD5) Previous issue date: 2012-11-23<br>The objective of this study was to evaluate the effect of arginine and ractopamine on performance, carcass characteristics, lipid profile and liver histological features in growing and finishing pigs. The experimental design was randomized blocks with three treatments, eight repetitions, two animals per experimental unit, for a total of 24 animals (12 barrows and 12 gilts) with

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32

Almeida, Vivian Vezzoni de. "Respostas produtivas e expressão gênica induzidas por períodos de fornecimento de ractopamina para suínos em terminação." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-29102012-104431/.

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O agonista beta-adrenérgico ractopamina (RAC) modifica a composição da carcaça suína por aumentar a massa muscular e reduzir a deposição de gordura. O objetivo neste estudo foi avaliar os efeitos do tempo de fornecimento de RAC sobre o desempenho, concentração de ureia plasmática (CUP), características de carcaça e expressão gênica dos receptores beta- adrenérgicos (beta-AR) e das isoformas da cadeia pesada de miosina (MyHC) em suínos em terminação. Oitenta suínos, machos castrados (PV inicial = 69,42 ± 1,24 kg), foram utilizados em um experimento em blocos completos casualizados com cinco tra

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33

Ebarb, Sara Michelle. "The influence of growth-promoting technologies on the biological structures responsible for cooked meat tenderness." Thesis, Kansas State University, 2015. http://hdl.handle.net/2097/20121.

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Master of Science<br>Department of Animal Sciences and Industry<br>John Michael Gonzalez<br>The objective of this body of work was to examine effects of growth-promoting technologies (GP) on Longissimus lumborum meat tenderness, focusing on alterations of muscle fiber cross-sectional area (CSA) and collagen solubility. Two studies were conducted and analyzed as randomized complete block designs with repeated measures with GP and day of postmortem aging (DOA) as main effects. Treatments consisted of: a control (CON), implant only (IMP), and implant and [beta]-adrenergic agonist (COMBO). The [be

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34

Al-Nasser, Faisal. "Beta-blockers in chronic heart failure." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406219.

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35

SCHAAF, LARRY JOE. "PHARMACOKINETIC STUDIES OF BETA-BLOCKERS AND FLUOROPYRIMIDINES." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/188129.

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Part I. The disposition kinetics of 5-fluorouracil (5-FU) and a 5-FU prodrug, 5'-deoxy-5-fluorouridine (5'dFUR), were investigated in twelve patients with colorectal carcinoma. Each patient randomly received either two single, intravenous (iv) doses of 5-FU (7.5 and 15 mg/kg) or 5'dFUR (2 and 4 g/m²) on separate days. In addition, the whole blood/plasma concentration ratio and stability of 5-FU and 5'dFUR at 37°C was determined in whole blood from normal volunteers and in five patients with colorectal carcinoma. A disproportionate increase in area under the curve and corresponding decrease in

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36

Georgsson, Jennie. "Design and Synthesis of Novel AT2 Receptor Ligands : From Peptides to Drug-Like Molecules." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6269.

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37

Verstappen, Annita A. (Annita Apollonia). "Cellular mechanisms of ocular hypotensive effects of a₂-adrenergic agonists." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc798263/.

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Th ocular bilateral hypotensive effect after unilateral topical administration of medetomidine and 4 analogs was demonstrated in a dose-response study (0.5%-2%) in NZW rabbits (bilateral IOP-lowering efficacy: medetomidine>detomidine and MPV-1440>MPV-1441 and MPV-305BIII).

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38

Zolty, Ronald. "Beta 1 and Alpha 2C adrenergic receptor polymorphisms and response to beta blockers in heart failure patients /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Clinical Science) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 130-142). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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39

Jilka, Sarah Marie 1960. "EXERCISE RESPONSE TO ACUTE AND CHRONIC BETA BLOCKADE IN HEALTHY MALE SUBJECTS." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/276436.

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The purpose of this study was to examine exercise responses during acute and chronic administration of BB, Beta Blockade. Twenty-eight healthy males performed maximal treadmill exercise tests after 1 day and 9 days of 3 double-blind, randomized conditions: a placebo (Pl), propanolol (Pr) 80 mg bid, and atenolol (At) 100 mg daily. Maximal heart rate (HR), oxygen consumption (VO₂), ventilation (VE), and treadmill time (TT) were significantly reduced by Pr and At after an acute and chronic dose. An acute dose of Pr and At caused a greater decrease in maximal HR compared to chronic administration

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40

Elliott, Christopher T. "Detection, pharmacokinetics and molecular mimicry of beta agonists." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247342.

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Sweet, Andrew. "#beta#-adrenergic agonists and lean deposition in animals." Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292616.

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42

Koch, Sarah. "Pharmacogenetics of inhaled beta-2-agonists and athletic performance." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/37901.

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The A46G single nucleotide polymorphism (SNP) and the C79G SNP of the adrenergic β2-receptor gene (ADRB2) are associated with the regulation of cardiorespiratory responses, to the inhalation of salbutamol, such as bronchodilation, heart rate and ventilation. PURPOSE: To determine (1) the effect of susceptibility to exercise-induced bronchoconstriction (EIB) and (2) the effect of genetic variation at the ADRB2 A46G and the C79G SNPs on athletic performance after the inhalation of salbutamol. METHODS: Genetic variation for the A46G SNP (AA: 4; AG: 15; GG: 21; unidentified: 2) and the C79G SNP

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Thompson-Coon, J. "Clinical studies on interactions between #beta#-agonists and glucocorticoids." Thesis, University of Nottingham, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285776.

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Gill, Hardyal S. "Soft [beta]-adrenoceptor agonists for topical use in psoriasis." Thesis, Aston University, 1994. http://publications.aston.ac.uk/11053/.

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Psoriasis is characterised by epidermal proliferation and inflammation resulting in the appearance of elevated erythematous plaques. The ratio of c~AMP/c~GMP is decreased in psoriatic skin and when the epidermal cell surface receptors are stimulated by β-adrenergic agonists, intracellular ATP is transformed into c-AMP, thus restoring the c~AMP/c~GMP levels. This thesis describes a series of β-adrenoceptor agonists for topical delivery based upon the soft-drug approach. Soft drugs are defined as biologically active, therapeutically useful chemical compounds (drugs) characterised by a predictabl

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45

Ajumobi, Taiwo. "Beta-Blockers Act through Clathrin-Dependent Internalization and EGFR Transactivation to Promote ERK Phosphorylation." Digital Commons @ Butler University, 2014. http://digitalcommons.butler.edu/grtheses/267.

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For cardiovascular diseases such as high blood pressure, angina pectoris, and left ventricle hypertrophy; long-term activation of beta-adrenergic receptors is strongly linked to the progression of these diseases. A class of antagonistic drugs that target betaadrenergic receptors are collectively called beta-blockers. These drugs are commonly used to reduce the inotropic and chronotropic effects of beta-adrenergic receptor activation. This past decade has revealed that beta-blockers and other ligands are capable of functional selectivity at receptors. Functional selectivity describes the abilit

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Short, Philip. "Evaluation of beta-blockers for the treatment of asthma and chronic obstructive pulmonary disease." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/2ec04592-d4c9-44da-9175-d92be119bf36.

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Beta-blockers are avoided in asthma and chronic obstructive pulmonary disease (COPD) due to the potential risk of drug induced bronchospasm. Despite these concerns, beta-adrenoceptor antagonism has recently been associated with potential therapeutics benefits in asthma. Furthermore the use of beta-blockers in COPD patients may potentially result in improved survival due to optimisation of treatment in those with concurrent cardiovascular disease. This thesis evaluates the role of beta-blocker use in asthma and COPD. The introduction outlines the pharmacological principles associated with the h

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Morales, Daniel. "Quantifying the risk of beta-blockers and non-steroidal anti-inflammatory drugs in asthma." Thesis, University of Dundee, 2014. https://discovery.dundee.ac.uk/en/studentTheses/56ca8828-73f6-47cc-b919-6e3e78e11a7b.

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Beta-blockers and non-steroidal anti-inflammatory drugs (NSAIDs) are often avoided in asthma over risk of bronchospasm which may vary according to drug selectivity and duration of administration. This thesis attempts to quantify the risk of beta-blocker and NSAID exposure in asthma by synthesising clinical trial evidence and conducting observational studies using linked electronic medical records. As part of this thesis, three systematic reviews of clinical trials were conducted evaluating: the prevalence of aspirin-exacerbated respiratory disease (AERD); risk of selective NSAIDs/COX-2 inhibit

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Calhoun, McKenzie L., L. Brian Cross, and Rhonda M. Cooper-Dehoff. "Clinical Utility of Beta-Blockers for Primary and Secondary Prevention of Coronary Artery Disease." Digital Commons @ East Tennessee State University, 2013. https://doi.org/10.1586/erc.13.16.

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Evaluation of: Bangalore S, Steg PG, Deedwania P et al. β-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA 308(13), 1340–1349 (2012). The number of myocardial infarctions (MIs) in population remains high and this event is a significant predictor of mortality. Information in the literature points to a reduction in mortality, reinfarction and sudden death in first year, especially in patients with high risk, if β-blockers (BBs) are used after MI. In a perspective study, Zuckerman et al. have determined outcome following pharmacotherapy after

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FREUND, BEAU JEFFERE. "THE EFFECTS OF BETA-ADRENERGIC BLOCKADE ON EXERCISE CAPACITY AND THERMOREGULATION IN TRAINED AND UNTRAINED SUBJECTS." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/187999.

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Two investigations were conducted to examine the influence of beta-adrenergic blockade on cardiovascular, respiratory, metabolic, and thermoregulatory responses to maximal and submaximal exercise in both highly trained and untrained subjects. In both studies, subjects received randomized and double-blind oral medication with atenolol (100 mg/day), propranolol (160 mg/day), and placebo. In the first study significant reductions in HR max and ‘VO₂ max resulted during the atenolol and propranolol treatments in both the trained and untrained subjects. However, the reductions in ‘VO₂ max were signi

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Bridges, Eileen Joan. "The effects of ß-blockers on exercise parameters in heart failure /." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78329.

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Purpose. To examine the outcome of a 6-month treatment with carvedilol or metoprolol on peak and submaximal exercise performance and ventilatory efficiency in patients with heart failure (HF).<br>Methods. 27 patients with HF were randomized to receive either metoprolol or carvedilol for 6 months and compared with 12 healthy controls. Maximal exercise capacity was assessed at baseline and after 6 months with a symptom limited incremental treadmill protocol (RAMP). Submaximal exercise was determined to be the portion of exercise below a respiratory exchange ratio of 1.0. Peak heart rate (H

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