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Дисертації з теми "And persistent inflammation"

Автор: Grafiati
Опубліковано: 7 червня 2025
Оновлено: 2 серпня 2025

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1

Inglis, Julia Jane. "Characterisation of novel nociceptive mechanisms during persistent inflammation." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413580.

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2

Lajunen, T. (Taina). "Persistent Chlamydia pneumoniae infection, inflammation and innate immunity." Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514289965.

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Анотація:
Abstract Chlamydia pneumoniae is an obligatory intracellular pathogen that causes upper and lower respiratory tract infections. Like other Chlamydial species, also C. pneumoniae has a tendency to cause persistent infections, which have been associated with different cardiovascular, neurological, and respiratory diseases. In addition, a few studies have reported an association between C. pneumoniae seropositivity and an elevated body mass index (BMI), and it has been shown that C. pneumoniae is capable of infecting preadipocytes and adipocytes. The main aims of this study were to study if certa
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3

Khurana, Shruti. "Lung physiology & airway inflammation in COPD patients with persistent sputum production." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/lung-physiology-and-airway-inflammation-incopd-patients-with-persistent-sputum-production(b0f3374e-9a67-4ff9-a51e-d94eefa2f13c).html.

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Background: The clinical and pathological presentation of COPD is heterogeneous. ‘Chronic bronchitis’ is a phenotype of COPD, which is a clinical diagnosis of a productive cough of ≥ 3 months for ≥ 2 consecutive years. Chronic bronchitis is associated with worse lung function, frequent exacerbations, recurrent hospitalisations and premature death in patients with COPD. Chronic bronchitis sufferers can be further subphenotyped into those who produce sputum during exacerbation or during winter months only and those who are ‘persistent sputum producers,’ who experience mucous hypersecretion throu
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4

Gao, Helen Guoyi Li. "INCREASED FIBROGENIC PROTEINS FOLLOWING PERSISTENT LOW-GRADE INFLAMMATION IN A RAT MODEL OF LONG-TERM OVERUSE." Master's thesis, Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/238810.

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Biomedical Sciences<br>M.S.<br>We examined the relationship between grip strength declines and muscle-tendon responses induced by long-term performance of a high-repetition, low-force (HRLF) reaching task in rats. We hypothesized that grip strength declines would correlate with inflammation, fibrosis and degradation in flexor digitorum muscles and tendons. Grip strength declined after training, and further in weeks 18 and 24, in reach limbs of HRLF rats. Flexor digitorum tissues of reach limbs showed low-grade increases in inflammatory cytokines: IL-1beta after training and in week 18, IL-1alp
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5

Glaros, Trevor Griffiths. "Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/73001.

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Анотація:
Low dose endotoxemia is caused by several health conditions including smoking, alcohol abuse, high fat diets, and aging. Several studies have correlated low dose endotoxemia with increased risks of atherosclerosis, diabetes, and Parkinson's disease. Unlike high doses of endotoxin which induce a strong but transient induction of pro-inflammatory mediators, low doses of endotoxin result in a mild but chronic induction of pro-inflammatory genes. The central hypothesis of our study was that if low doses of endotoxin are capable of inducing mild prolonged inflammation, then a unique signaling ci
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6

Roberts, Jill Marie. "The Role of Glial Activation in Descending Facilitation from the Rostroventromedial Medulla (RVM) in Models of Persistent Pain." Diss., The University of Arizona, 2009. http://hdl.handle.net/10150/194471.

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Анотація:
Substantial evidence shows that activation of glial cells in the spinal cord may promote central sensitization and enhancement of pain. Descending facilitation from the rostroventromedial medulla (RVM) is also recognized as a critical component in the maintenance of chronic pain states, although the precise mechanisms driving this activity are unclear. Here, we investigated the possibility that glial activation in the RVM could promote descending facilitation from the RVM in states of enhanced pain. Peripheral inflammation was induced with carrageenan injected into the plantar aspect of the hi
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7

Mahdavi, Jafar. "Helicobacter pylori adhesion and patho-adaptation : the role of BabA and SabA adhesins in persistent infection and chronic inflammation." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-271.

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8

Pitcher, Mark H. "The effects of persistent peripheral inflammation on the ultrastructural localization of spinal cord dorsal horn group I metabotropic glutamate receptors /." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98770.

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Анотація:
Persistent peripheral inflammation is thought to induce functional plasticity of spinal dorsal horn neurons, and may produce changes in glutamate receptor expression. Alterations in expression and cellular localization of group I metabotropic glutamate receptors (mGluR1alpha and mGIuR5) is important in various neuronal systems, and these receptors are also known to modulate nociceptive neurotransmission in the spinal dorsal horn. The aim of the present study is to determine whether persistent inflammation produces alterations in ultrastructural localization of mGluR1alpha and mGluR5 in the dor
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9

Myre, Maxine. "Exploring the Independent and Combined Effects of Persistent Organic Pollutants and Hypoxia on Human Adipocyte Functions." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/30416.

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Анотація:
Persistent organic pollutants (POPs) and adipose tissue hypoxia have been shown to independently affect adipocyte functions. The goals of this study were to (1) determine the effect of PCB-77, PCB-153, and DDE on the differentiation of human preadipocytes, and (2) investigate the cross-talk between PCB-77 and hypoxia in differentiated human adipocytes. First, human preadipocytes were exposed to PCB-77, PCB-153, or DDE during the entire 14-day differentiation period. We found no effect of low POP levels on lipid accumulation. Second, differentiated human adipocytes were exposed to a combination
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10

Gascon, Merlos Mireia 1984. "Persistent organic pollutants, bisphenol A, phthalates and respiratory and immune health in childhood." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/145922.

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Анотація:
Persistent organic pollutants (POPs), bisphenol A (BPA) and pthalates may increase the risk of respiratory infections and allergic diseases in infants and the effects might last until, at least, adolescence. Cytokines and biomarkers of inflammation can provide information of the mechanisms behind such associations. Data from the “Infancia y Medioambiente” (INMA) population-based birth cohort project and from six other existing European birth cohort studies have been used in the present thesis, which also includes a systematic review. Results of the present work, which includes five scientific
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11

Carey, Alison Jane. "Development of novel vaccine strategies to prevent genital tract chlamydial infections." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/48734/1/Alison_Carey_Thesis.pdf.

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Анотація:
Chlamydia trachomatis is the most prevalent bacterial sexually transmitted infection in the developed world and the leading cause of preventable blindness worldwide. As reported by the World Health Organization in 2001, there are approximately 92 million new infections detected annually, costing health systems billions of dollars to treat not only the acute infection, but also to treat infection-associated sequelae. The majority of genital infections are asymptomatic, with 50-70% going undetected. Genital tract infections can be easily treated with antibiotics when detected. Lack of treatment
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12

Pesonen, Izabell, and Midia Ismail. "Immunhistokemisk (IHC) analys av låggradigt inflammerade biopsier med apikal parodontit -en pilotstudie." Thesis, Malmö universitet, Odontologiska fakulteten (OD), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-42574.

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Анотація:
Syfte: Att ta reda på hur relationen ser ut för B- respektive T-lymfocyter i biopsier av rotfyllda tänder med apikal parodontit med bedömd låggradig inflammation. Denna studie kommer även att analysera hur den inflammatoriska bilden ser ut i förhållande till beskrivna symtom i dessa biopsier. Material &amp; metod: En pilotstudie utfördes på 10 biopsier från rotfyllda tänder med apikal parodontit med bedömd låggradig inflammation enligt Danesh et al 2019 klassificeringssystem. Biopsierna hämtades från Malmö universitets biobank. Immunhistokemisk infärgning av antigenerna CD20+ och CD3+ utfördes
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13

Griffith, David Morgan. "Persisting inflammation after critical illness : prevalence, risk factors and association with physical recovery." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/23955.

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Анотація:
Introduction: Survivors of critical illness suffer physical, psychological, and social problems. The factors hindering recovery and the best rehabilitation interventions remain illusive. Critical illness is associated with inflammation that persists in some individuals and this might affect recovery. The hypotheses for the thesis are 1. Persistent inflammation is common after critical illness. 2. Persistent inflammation is associated with functional recovery. 3. Persistent inflammation is associated with critical illness-induced viral reactivation. 4. Biomarkers may help predict functional dis
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14

Wendelsdorf, Katherine Veronica. "Models of the Mucosal Inflammatory and Regulatory Immune Pathways: The Role of Host Response in Microbial Persistence and Pathogenesis." Diss., Virginia Tech, 2011. http://hdl.handle.net/10919/29717.

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Анотація:
The scientific method requires the creation of a unifying hypothesis that reconciles an observed health outcome of infection with experimental data gathered about the disease process following infection. In this era of unprecedented amounts of data and information for various disease models, the creation and articulation of such hypothesis are often beyond human capacity. Modeling offers a means to generate hypothesis that provide complex mechanisms that reconcile seemingly contradictory data as well as quantitatively assess the relative plausibility of different mechanisms proposed to explain
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15

Alidjinou, Enagnon Kazali. "Infection à coxsackievirus B4, inflammation et persistance." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S022/document.

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Анотація:
Les coxsackievirus du groupe B (CVB) sont des petits virus à ARN appartenant à au genre Enterovirus et à la famille des Picornaviridae. Chez, l’homme, les CVB sont responsables de nombreuses infections aiguës bénignes ou sévères. Ils sont également incriminés dans le développement de maladies chroniques telles que le diabète de type 1 (DT1). En effet, plusieurs données épidémio-cliniques sont en faveur d’un lien entre les entérovirus et notamment les CVB et le DT1. Deux mécanismes majeurs ont été proposés pour expliquer cette pathogenèse entérovirale du DT1. Il s’agit de l’activation « en pass
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16

Reghini, Maria Fernanda Svizzero. "Efeito do tratamento com plasma rico em plaquetas em éguas resistentes e susceptíveis à endometrite persistente após inseminação artificial /." Botucatu : [s.n.], 2013. http://hdl.handle.net/11449/98176.

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Orientador: Marco Antônio Alvarenga<br>Banca: Regina Kiomi Takahira<br>Banca: Marcio Teoro do Carmo<br>Resumo: A endometrite persistente pós-cobertura (EPPC) é uma das principais causas da redução de fertilidade em éguas. Recentes estudos têm demonstrado a importância da imunomodulação da inflamação após a cobertura. O objetivo deste trabalho foi verificar o estímulo do sêmen na resposta inflamatória uterina de éguas resistentes e susceptíveis à endometrite após a inseminação artificial (IA) e propor um novo tratamento a fim de debelar a resposta inflamatória uterina exacerbada, com o uso do p
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17

Reghini, Maria Fernanda Svizzero [UNESP]. "Efeito do tratamento com plasma rico em plaquetas em éguas resistentes e susceptíveis à endometrite persistente após inseminação artificial." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/98176.

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Анотація:
Made available in DSpace on 2014-06-11T19:29:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-01-24Bitstream added on 2014-06-13T20:59:33Z : No. of bitstreams: 1 reghini_mfs_me_botfmvz.pdf: 448724 bytes, checksum: aab02e07ff9da14fae416999c62b6198 (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>A endometrite persistente pós-cobertura (EPPC) é uma das principais causas da redução de fertilidade em éguas. Recentes estudos têm demonstrado a importância da imunomodulação da inflamação após a cobertura. O objetivo deste trabalho foi verificar o estímulo do sêmen
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18

Bernotiene, Eiva. "Inflammation aiguë persistante en réponse à l'injection intra-articulaire de Zymosan chez les souris déficientes en leptine ou en son récepteur /." Genève : [s.n.], 2005. http://www.unige.ch/cyberdocuments/theses2005/BernotieneE/these.pdf.

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19

Segabinazzi, Lorenzo Garrido Teixeira Martini [UNESP]. "Efeito do plasma rico em plaquetas pré ou pós inseminação artificial sobre a resposta inflamatória e índice de fertilidade em éguas susceptíveis a endometrite persistente pós-cobertura." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/144634.

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Анотація:
Submitted by LORENZO GARRIDO TEIXEIRA MARTINI SEGABINAZZI null (lorenzosegabinazzi@unesp.com.br) on 2016-11-11T16:37:12Z No. of bitstreams: 1 Dissertação de mestrado Lorenzo FINAL.pdf: 2227722 bytes, checksum: 5a7e643913e44a96155c8fd80a611918 (MD5)<br>Approved for entry into archive by LUIZA DE MENEZES ROMANETTO null (luizaromanetto@hotmail.com) on 2016-11-16T16:09:30Z (GMT) No. of bitstreams: 1 segabinazzi_lgtm_me_bot.pdf: 2227722 bytes, checksum: 5a7e643913e44a96155c8fd80a611918 (MD5)<br>Made available in DSpace on 2016-11-16T16:09:31Z (GMT). No. of bitstreams: 1 segabinazzi_lgtm_me_bot.
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20

Evaristo, Karen Brandão. "Comparação entre exercício aeróbio e respiratório no controle clínico e inflamação pulmonar de pacientes com asma persistente moderada ou grave: ensaio clínico aleatorizado." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5170/tde-20042016-113329/.

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Анотація:
A asma é uma doença inflamatória crônica das vias aéreas caracterizada por obstrução reversível, inflamação e hiperresponsividade a diversos estímulos. O exercício, seja ele de caráter aeróbio ou respiratório, é muito utilizado no tratamento de pacientes asmáticos, porém, pouco se sabe sobre os benefícios desses exercícios no processo inflamatório e no manejo clínico dessa doença. Objetivo: Comparar o efeito do exercício aeróbio e respiratório no controle clínico, inflamação pulmonar e capacidade funcional de pacientes com asma persistente moderada ou grave. Métodos: Foram estudados 50
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21

Alba, Garibay Marco Antonio. "Persistence of inflammatory activity in giant cell arteritis:Role of the angiotensin II system." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/283754.

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Giant cell arteritis (GCA) is a systemic vasculitis of unknown aetiology that affects medium-sized and large arteries. GCA may deeply impair the patient's quality of life as a result of systemic smouldering activity, disease progression or adverse effects related to therapy. The present thesis is a compendium of four articles assessing clinical and immunopathological characteristics associated with persistence of chronic inflammation in GCA patients. In the first publication, we described the clinical course of a small series of GCA patients derived from Latin America, a geographic area whe
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22

Terrades, Garcia Nekane. "Interleukin-6 (IL-6)/IL-6 receptor and persistence of inflammation in Giant Cell Arteritis. Effects of IL-6 receptor blockade with tocilizumab." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/668038.

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Анотація:
Giant cell arteritis (GCA) is a chronic granulomatous vasculitis affecting large- and medium-sized vessels. This disease can lead to different symptoms related to vascular or systemic inflammation, such as fever and visual loss, and its exact etiology remains to be elucidated. Current treatment of GCA patients is based on glucocorticoids administration. However, not all patients respond properly to this treatment and the disadvantages associated to glucocorticoids promotes the search for new therapeutic alternatives. Blockade of IL-6 signaling with tocilizumab (TCZ), a humanized monoclonal an
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23

Mendes, Felipe Augusto Rodrigues. "Efeito do treinamento físico nos aspectos psicossociais, modulação autonômica e inflamação pulmonar em pacientes com asma persistente moderada ou grave." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5163/tde-10032010-110259/.

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Анотація:
A asma é uma doença com alta prevalência e leva a importantes danos funcionais à saúde e à qualidade de vida do paciente. A fisiopatologia da doença está centrada na inflamação crônica das vias aéreas que associada a uma disfunção do sistema nervoso autônomo (SNA) favorece a hiper-reatividade e à obstrução brônquica. O treinamento físico pode modular a resposta autonômica e imune em indivíduos saudáveis e a sua prática de maneira regular também é recomendada para os pacientes asmáticos. Porém, permanece pouco compreendido o efeito do treinamento físico sobre a inflamação pulmonar e a modulação
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24

Mendes, Felipe Augusto Rodrigues. "Efeito do exercício físico na inflamação pulmonar e na resposta imunológica sistêmica em pacientes com asma persistente moderada ou grave." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-17012014-110145/.

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Анотація:
A asma é uma doença pulmonar inflamatória crônica com alta prevalência e que leva a importantes danos funcionais à saúde e à qualidade de vida do paciente. A fisiopatologia da asma é caracterizada por intensa imunorregulação e o exercício físico pode ter um papel importante nesta resposta inflamatória devido a seus efeitos imunorreguladores. Objetivo: Avaliar o efeito de um programa de treinamento físico aeróbio na inflamação sistêmica e pulmonar, no controle clinico e fatores de saúde relacionados à qualidade de vida controle clínico de pacientes adultos com asma persistente moderada ou grave
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25

Saad, Carla Gonçalves Schahin. "Baixos níveis de esclerostina: preditor de processo inflamatório persistente em pacientes com espondilite anquilosante sob terapia anti-TNF&#945." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5164/tde-09012013-180110/.

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Анотація:
Introdução: Baixas concentrações séricas de esclerostina foram descritas em pacientes com Espondilite Anquilosante (EA). No entanto, não existem dados sobre a importância deste inibidor da via de sinalização Wnt em pacientes com EA durante o tratamento com anti fator de necrose tumoral alfa (TNFa). Objetivos: Avaliar longitudinalmente os níveis séricos de esclerostina e sua associação com inflamação e densidade mineral óssea (DMO) em pacientes com EA em tratamento com anti-TNFa. Métodos: Trinta pacientes com EA em atividade foram avaliados no início, 6 e 12 meses, após terapia anti-TNF
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26

Soualeh, Nidhal. "Évaluation des effets neuro-inflammatoires de l’exposition périnatale aux anguilles (Anguilla anguilla L.) contaminées naturellement aux polluants organiques persistants sur le comportement et les fonctions cognitives dans un modèle murin." Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0288/document.

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Анотація:
Dans ce travail de thèse, nous avons évalué les effets inflammatoires, comportementaux et cognitifs de l’exposition périnatale des souris à trois matrices alimentaires d’anguilles, reflétant 3 niveaux de pollution (faible, moyenne et haute), tout en considérant le sexe de la progéniture ainsi que les différentes phases d’âges. Les réponses inflammatoires ont été évaluées, aussi bien au niveau cérébral, y compris dans les cellules de la microglie, qu’au niveau périphérique, à 4 stades de vie distincts, et ce dès la naissance jusqu’à l’âge moyen. Chez les souriceaux, mâles et femelles, dont leur
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27

Martin, Lydie. "Développement et caractérisation d'un modèle d'infection non lytique de cellules de Leydig par le virus de l'Artérite Virale Equine." Thesis, Normandie, 2018. http://www.theses.fr/2018NORMC201.

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Анотація:
Le virus de l’Artérite Virale Équine (EAV) est un virus à ARN simple brin positif, appartenant à la famille des Arteriviridae, dans l’ordre des Nidovirales. C’est un virus spécifique des équidés qui peut être transmis par voies respiratoire et vénérienne. Lors de la primo-infection, l’EAV peut entraîner des signes cliniques grippaux, mais de façon plus grave, il peut aussi provoquer l’avortement des juments gestantes ainsi que la mort des nouveau-nés. L’EAV représente donc un enjeu économique majeur pour la filière équine. Suite à la primo-infection, ce virus peut persister dans de l’appareil
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28

Eendebak, Robert. "The potential relationships between hormone biomarkers and functional and health outcomes of ageing." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/the-potential-relationships-between-hormone-biomarkers-and-functional-and-health-outcomes-of-ageing(e28321cc-703c-44df-99b4-fb0d76f7f429).html.

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Анотація:
Although the female menopause has been extensively characterized as a well-defined symptomatic state of oestrogen deficiency, which responds relatively well to oestrogen replacement therapy, the symptomatic state of androgen deficiency in men is poorly defined and uncertainty exists whether it responds to testosterone replacement. It has been proposed that hypothalamic-pituitary-testicular (HPT)-axis function (responsible for the production of androgens) and regulation could be viewed as a ‘barometer’ of health status in older men and that potential alterations in HPT-axis function and reg
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29

Chen, Tzu-Ling, and 陳姿伶. "Persistent Gut Barrier Dysfunction and Mucosal Inflammation after Eradication of Giardia lamblia Infection: Implications for the Pathogenesis of Post-Infectious Irritable Bowel Syndrome." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/11174899024110726388.

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Анотація:
碩士<br>國立臺灣大學<br>生理學研究所<br>98<br>Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and changes in bowel habits, for which neither apparent structural lesion nor presence of pathogen could be found. Recent data indicated that low grade intestinal inflammation, impaired mucosal barrier function, and enteric bacterial overgrowth were identified in IBS patients. Consistent evidence showed that IBS may be the adverse outcome of an acute episode of infectious gastroenteritis, termed post-infectious (PI) IBS. Giardia lamblia is the most frequently
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30

Malty, Ramy Refaat Habashy. "Mechanisms of the downregulation of prostaglandin E₂-activated protein kinase A after chronic exposure to nerve growth factor or prostaglandin E₂." Thesis, 2013. http://hdl.handle.net/1805/3626.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Chronic inflammatory disorders are characterized by an increase in excitability of small diameter sensory neurons located in dorsal root ganglia (DRGs). This sensitization of neurons is a mechanism for chronic inflammatory pain and available therapies have poor efficacy and severe adverse effects when used chronically. Prostaglandin E₂ (PGE₂) is an inflammatory mediator that plays an important role in sensitization by activating G-protein coupled receptors (GPCRs) known as E-series prostaglandin receptors (EPs) coupled to the protein
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Lin, Yu-Tsan, and 林于粲. "Molecular Mechanisms that Staphylococcal Superantigens Contribute to the Persistence and Exacerbation of Allergic Skin Inflammation in Atopic Dermatitis." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/03509035144333985378.

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博士<br>國立臺灣大學<br>臨床醫學研究所<br>93<br>The skin of atopic dermatitis (AD) patients exhibits a striking susceptibility to colonization and infection with Staphylococcus aureus, which can secrete various exotoxins including staphylococcal enterotoxin B (SEB) being the most common. These exotoxins are superantigens. They may penetrate the skin barrier, stimulate T cells bearing the specific variable region of beta chain of T cell receptor (TCRVbeta), and contribute to the persistence and exacerbation of allergic skin inflammation in AD. The objective of this study was to clarify the molecular mechanis
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Mpiga, Philomène. "Caractérisation des infections à Chlamydia trachomatis persistantes induites par l'action des antibiotiques." Thèse, 2005. http://hdl.handle.net/1866/15145.

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