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Дисертації з теми "Anti-tumor agent"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Jain, Neera. "Preformulation and formulation studies of RH1: A new investigational anti-tumor agent." Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/290568.

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Currently, the National Cancer Institute is investigating RH1 for its potential use as an anti-tumor agent. A parenteral formulation is desired but the drug is highly unstable in aqueous solutions. Various effects on the stability of RH1 are investigated. All the reactions of RH1 follow first-order kinetics. The maximum shelf-life, obtained in neutral conditions, is about one week. The pH-rate profile shows slopes of approximately -1 in acidic conditions and +1 in basic conditions indicating that the degradation of RH1 is specific acid-base catalyzed. The energies of activation at pH's 6.0 and

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2

Fedeleş, Bogdan I. "The androgen receptor independent mechanism of toxicity of the novel anti-tumor agent 11[beta]-dichloro." Thesis, Massachusetts Institute of Technology, 2009. http://hdl.handle.net/1721.1/61222.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biological Engineering, 2009.<br>In title on title-page "[beta]" appears as the lower-case Greek letter. Vita. Page 284 blank. Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Inspired by the toxicity mechanism of cisplatin in testicular cancer, a series of bi-functional genotoxicants has been designed that supplement their DNA damaging properties with the ability to interact with tumor specific proteins. One such compound, 11[beta] -dichloro links an aniline mustard moiety to a steroid ligand for

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3

LOPEZ, RIVAS PAULA. "SYNTHESIS OF INTEGRIN-TARGETING PRO-DRUGS FOR THE SELECTIVE RELEASE OF ANTI-TUMOR AGENTS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/584099.

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In this PhD work, a variety of new SMDCs were designed and synthesized featuring different types of linkers and cytotoxic payloads. All of them were characterized and conjugated to peptidomimetic ligands bearing the RGD sequence (namely, the cyclo[DKP-RGD] and cyclo[RDGfK] compounds) aimed at targeting αVβ3 integrin receptor, which is overexpressed in many human cancers. Firstly, six new conjugates containing peptide linkers prone to cleavage in intracellular vesicles (such as the lysosomes) were synthesized and evaluated in vitro. The loss of potency generally displayed by these SMDCs in ant

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4

Wiesmann, Nadine [Verfasser]. "Analysis of the toxicity mechanism of zinc oxide nanoparticles aiming at their application as innovative anti-tumor agent / Nadine Wiesmann." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1186315172/34.

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5

BAN, NOBUTARO, YUKITOSHI TAKAHASHI, GEN SOBUE, et al. "LIMBIC ENCEPHALITIS ASSOCIATED WITH RELAPSING POLYCHONDRITIS RESPONDED TO INFLIXIMAB AND MAINTAINED ITS CONDITION WITHOUT RECURRENCE AFTER DISCONTINUATION : A CASE REPORT AND REVIEW OF THE LITERATURE." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/20556.

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6

McCray, Andrea Nicole. "Electrogenetherapy of established B16 murine melanoma by using an expression plasmid for HIV-1 viral protein R." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001758.

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7

Lee, Yee Man. "Anti-tumor mechanisms of 2-methoxyestradiol in nasopharyngeal carcinoma." HKBU Institutional Repository, 2007. http://repository.hkbu.edu.hk/etd_ra/866.

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8

Southerland, Marie R. "SYNTHESIS AND BIOLOGICAL EVALUATION OF IMIDAZOLIUM SALTS AS ANTI-CANCER AGENTS." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524075623735265.

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9

Zhu, Eric F. (Eric Franklin). "Synergistic anti-tumor immune response to combination immunotherapy consisting of anti-tumor antibodies, extended half-life Interleukin-2, and other immunomodulatory agents." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107872.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 109-123).<br>Cancer immunotherapies under development have generally focused on either stimulating T-cell immunity or driving antibody-directed effector functions of the innate immune system such as antibody-dependent cell-mediated cytotoxicity (ADCC). However, as our understanding of antitumor immune responses grows, it has become increasingly apparent that single agent therapies may be insufficient to effective

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10

Lu, Qiang. "Potent short-chain fatty acid-based histone deacetylase inhibitors as anti-tumor agents." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117541292.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xix, 116 p.; also includes graphics. Includes bibliographical references (p. 106-116). Available online via OhioLINK's ETD Center

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11

Chou, Chih-Chien. "Inhibition of Epithelial-to-Mesenchymal Transition by Anti-tumor Agents in Cancer Cells." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1396875461.

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12

Xu, Jin. "Synthesis of novel sulfonamide-based calpain inhibitors and their potential as anti-tumor agents." View the abstract Download the full-text PDF version, 2007. http://etd.utmem.edu/WORLD-ACCESS/Xu/2007-028-Xu.pdf.

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Thesis (M.S. )--University of Tennessee Health Science Center, 2007.<br>Title from title page screen (viewed on July 28, 2008). Research advisor: Dr. Isaac O. Donkor, Ph.D. Document formatted into pages (xii, 80 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 65-80).

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13

BOSIO, ALESSIA GRAZIANA. "IDENTIFICATION OF NOVEL BIGUANIDE BASEDCOMPOUNDS AS ANTI TUMOR AGENTS FOR GLIOBLASTOMA: PHARMACOLOGICAL ASSESSMENT IN 3D CULTURE MODELS." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1090330.

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Glioblastoma (GBM) is the most common malignant and aggressive adult brain tumour characterized by its clinical behaviour, with high growth rate, diffuse invasiveness, and low response to therapies. Despite of multimodal treatment, which consists in extensive surgery followed by radiotherapy and chemotherapy (temozolomide, TMZ) the mean life expectancy for patients with GBM is less than 2 years. Although remarkable research efforts have been done in the last decades, no significant improvement in patient survival have been obtained from 2005, also due to the lack of appropriate models to study

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14

Gomes, Erica Manuela Tong Alex W. "Anti-tumor properties of CD40 ligand when delivered as a transgene by the conditional replicative oncolytic adenovirus AdEH to breast cancer cells." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4901.

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15

Lallemand, Benjamin. "Development of novel anticancer glycyrrhetinic acid derivatives with marked anti tumor activity: synthesis and pharmacological evaluation of their activity." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209598.

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La plupart des molécules utilisées en chimiothérapie conventionnelle, bien qu’ayant des cibles moléculaires différentes, induisent dans la majorité des cas une mort cellulaire par apoptose. Or, de plus en plus de chimiorésistances se rencontrent au niveau des cellules cancéreuses vis-à-vis de ce type de molécules. Face à cette situation il devient urgent de trouver des molécules ayant des mécanismes d’action différents et capables de court-circuiter spécifiquement les mécanismes de résistance des cellules cancéreuses. <p>La stratégie mise en place lors de ce travail a été de partir d’une moléc

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16

Karambelkar, Vineet V. "Proposed Route to Cyclopenta[c]thiophenes via Activated Methylene." TopSCHOLAR®, 2008. http://digitalcommons.wku.edu/theses/25.

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The synthesis of cyclopenta[c]thiophenes has been sparsely reported in the literature owing to several difficulties involved in their synthesis. The present work involves the proposed synthesis of cyclopenta[c]thiophenes and their precursors using activated methylene. Cyclopenta[c]thiophene compounds show promise in the field of polymer and catalysis chemistry. These substituted polythiophenes are potential organic semiconductors and anti-tumor agents. The research presented shows the successful and novel conversion of 3,4-bis(chloromethyl)-2,5-dimethylthiophene and 3,4-bis(bromomethyl)-2,5

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17

MELEDDU, RITA. "Synthesis of different series of small molecules targeting HIV-1 RT, Candida albicans, MAO and G-Quadruplex." Doctoral thesis, Università degli Studi di Cagliari, 2013. http://hdl.handle.net/11584/266235.

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My PhD work has been focused towards four different targets: HIV-1 RT, Candida albicans, Monoamine oxidase, and G-Quadruplex. Thus in order to give the reader a clearer exposition this report has been divided in four different chapters. Each of the chapters has his own figures, schemes, tables and references. The main part of my work has been dedicated to HIV-1 RT, thus this chapter is the major and first one.

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18

Castan, Agnès. "Inhibition de l'angiogenèse tumorale : criblage d'une chimiothèque et caractérisation d'un nouveau composé agissant sur la voie de signalisation Ras-ERK." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV017/document.

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Au cours des dernières années, des thérapies anti-cancéreuses ciblant l'angiogenèse tumorale ont été développées et ont démontré un bénéfice en terme de survie globale pour les patients atteints de certains cancers métastatiques. Cependant, dans de nombreux cas, les tumeurs acquièrent des résistances échappent au traitement. Le développement de nouveaux composés anti-angiogène est donc une réelle nécessité pour être proposés en seconde ligne thérapeutique. Dans ce travail, notre objectif était d'identifier de nouvelles molécules anti-angiogènes par le criblage à haut débit, de la chimiothèque

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19

Dunja, Jakovljević. "Biološko dejstvo vodenog ekstrakta ploda štavelja (Rumex crispus L., Polygonaceae)." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110304&source=NDLTD&language=en.

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&Scaron;tavelj (Rumex crispus, Polygonaceae) je vi&scaron;egodi&scaron;nja zeljasta biljka, koja predstavlja bogat izvor fenolnih komponenti. Iako se smatra invazivnim korovom, mlado li&scaron;će &scaron;tavelja je jestivo i često se koristi kao salata. Dalje, upotreba plodova &scaron;tavelja opisana je u srpskoj i turskoj narodnoj medicini u lečenju gastrointestinalnih tegoba. Cilj ovog rada bio je procena in vitro i in vivo antioksidantne/prooksidantne i citotoksične aktivnosti, i određivanje eventualnog in vitro antiinflamatornog efekta vodenog ekstrakta ploda Rumex crispus. Ukupan sadržaj

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20

Foulke-Abel, Jennifer. "Natural Product Biosynthesis: Friend or Foe? From Anti-tumor Agent to Disease Causation." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-12-8705.

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Biosynthetic natural products are invaluable resources that have been gleaned from the environment for generations, and they play an essential role in drug development. Natural product biosynthesis also possesses the latent ability to affect biological systems adversely. This work implements recent advances in genomic, proteomic and microbiological technologies to understand further biosynthetic molecules that may influence progression of human disease. Azinomycin A and B are antitumor metabolites isolated from the terrestrial bacterium Streptomyces sahachiroi. The azinomycins possess an unusu

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21

Nogueira, Vanda Cristina Simões. "Role of adenosine on the resistance to temozolomide anti-tumor agent in glioblastoma." Master's thesis, 2020. http://hdl.handle.net/10400.6/10537.

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Glioblastoma is a primary brain tumor of glial cells with a high incidence in adults and is one of the most abundant brain cancer pathologies. This type of tumor is associated with high genomic instability caused by global hypomethylation of the DNA, that induces activation of oncogenes, loss of imprinting and increased genomic instability. Adenosine is a purine nucleoside important to neuroprotection, neuromodulation, synaptic plasticity and immunomodulation. In hypoxic and stress regions in the brain tumors, commonly found in glioblastoma, factors induced by hypoxia (HIF) are activated. Thes

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22

CHUNG, CHIEN-MIN, and 鐘健旻. "Study of the effect of anti-inflammatory agent curcumin on obesity-induced mammary tumor growth and metastasis." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/neu4sz.

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碩士<br>國立臺北護理健康大學<br>運動保健研究所<br>106<br>Obesity is a growing global health problem, obesity has been demonstrated to induce chronic inflammation and promote tumor growth and metastasis, and is a risk factor for cancer recurrence and metastasis. Myeloid-derived suppressor cells (MDSCs) and immune checkpoints are also implicated in the promotion of tumor metastasis by protecting metastatic cancerous cells from immune surveillance. Obesity recently was showed to induce the expression of proinflammatory cytokines and MDSCs resulting in tumor metastasis. The goal of this study was to investigate the

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23

"The Molecular Mechanism of Histone Deacetylase (HDAC) Inhibitor PCI-24781 as an Anti-tumor Agent in Neuroblastoma Cells." 2013. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1292174.

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7－10％的兒科腫瘤是神經母細胞瘤, 並且它是最普遍的腦顱外的實體瘤。儘管使⽤用多個⾼高強度的治療⽅方案，被診斷有⾼高危神經母細胞瘤病人的存活率仍然低於40％。這更加突出了對於新的治療策略的迫切要求。組蛋⽩白去⼄乙酰化酶抑制劑是⼀一類新的有前景的抗腫瘤藥物，它們在臨床上已經⽤用於許多類型的腫瘤的治療。PCI-24781 是⼀一種新型的屬於异羟肟酸家族的組蛋⽩白去⼄乙酰化酶抑制劑，對於癌症的治療俱有⾼高效率性和安全性。然⽽而，PCI-24781 對於神經母細胞瘤作⽤用的潛在機制仍然不是很清楚。<br>本文的研究显⽰示了以⾮非常低剂量的PCI-24781 的處理顯著地抑制神經母細胞瘤的細胞株SK-N-DZ 的⽣生⾧長，⽽而對於正常的細胞株HS-68 沒有影響。但是，PCI-24781 都能增加這兩個細胞株的乙酰化的組蛋白H3 的水平。PCI-24781 的處理能誘導SK-N-DZ 細胞的細胞週期停滯在G2/M 期，並且產⽣生⼤大量的sub-G1的凋亡細胞。對於凋亡信號通路的分析發現PCI-24781 能激活外在的和內在的凋亡信號通路。被上調的和凋亡相關的蛋⽩白質包括DR4, p21, p53, caspase3 以及斷裂的 caspase3。<br>進一步的蛋白質組學的分析顯示了在未處理和經過PCI-24781 處理的SK-N-DZ 細胞的不同的蛋⽩白表達譜。總共有42 個差

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24

Reznik, Samuel Kaye. "Methodological Innovations in Polyketide Synthesis and their Application toward the Scalable Synthesis of Anti-Tumor Agent Spongistatin 1." Thesis, 2012. https://doi.org/10.7916/D8Q246C5.

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This thesis describes the efforts of the Leighton laboratory to develop a scalable synthetic route to access anti-tumor agent spongistatin 1, or analogs thereof. In an effort to achieve this goal, several new chemical reaction platforms were established. Though these novel chemical transformations were developed specifically for use in the total synthesis of spongistatin 1, their potential application to general polyketide synthesis has been demonstrated. These methodological innovations have allowed our laboratory to take tremendous strides toward the longterm goal of helping to bring a poten

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25

Hochhauser, Daniel, Timothy Meyer, Victoria J. Spanswick, et al. "Phase 1 Study Of A Sequence Selective Minor Groove DNA Binding Agent (SJG-136) with Pharmacokinetic and Pharmacodynamic Measurements in Patients with Advanced Solid Tumours." 2009. http://hdl.handle.net/10454/4564.

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PURPOSE: This phase I dose-escalation study was undertaken to establish the maximum tolerated dose of the sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors. The study also investigated antitumor activity and provided pharmacokinetic and pharmacodynamic data. EXPERIMENTAL DESIGN: Sixteen patients were assigned sequentially to escalating doses of SJG-136 (15-240 microg/m(2)) given as a 10-minute i.v. infusion every 21 days. The dose was subsequently reduced in incremental steps to 45 microg/m(2) due to unexpected toxicity. RESULTS: The maximum tol

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26

"Anti-tumor activity of a fungal extract." 1999. http://library.cuhk.edu.hk/record=b5890002.

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by Joyce Chui Kwan Ho.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1999.<br>Includes bibliographical references (leaves 61-75).<br>Abstracts in English and Chinese.<br>Acknowledgments --- p.i<br>List of Abbreviations --- p.iii<br>Abstract<br>English --- p.1<br>Chinese --- p.2<br>Chapter Chapter 1 --- General Introduction<br>Chapter 1.1 --- Tumor Formation --- p.3<br>Chapter 1.2 --- Anti-tumor Pathways --- p.4<br>Chapter 1.3 --- Aim of Project --- p.13<br>Chapter Chapter 2 --- The In Vivo effect of Polysaccharopeptide<br>Chapter 2.1 --- Introduction --- p.15<br>Chapter 2.2 ---

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27

"Capsular polysaccharides from Klebsiella pneumoniae as anti-tumor agents." 1999. http://library.cuhk.edu.hk/record=b5890082.

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by Tang Yan Chi.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1999.<br>Includes bibliographical references (leaves 156-168).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGEMENTS --- p.I<br>ABBREVIATIONS --- p.II<br>ABSTRACT --- p.V<br>ABSTRACT (CHINESE) --- p.VII<br>TABLE OF CONTENT --- p.1<br>GENERAL INTRODUCTION --- p.4<br>Chapter 1.1. --- Immunotherapy in Cancer --- p.4<br>Chapter 1.1.2. --- Cytokines used in Immunotherapy in Cancer --- p.5<br>Chapter 1.1.2.1. --- Interferons (IFNs) --- p.6<br>Chapter 1.1.2.2. --- interleukins (ILs) --- p.11<br>Chapter 1.1.2.3. --

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28

"Study on the in vitro anti-tumor effect of Acanthopanax senticosus." 2008. http://library.cuhk.edu.hk/record=b5893590.

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Wan, Chung Tin.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2008.<br>Includes bibliographical references (leaves 126-139).<br>Abstracts in English and Chinese.<br>Thesis / Assessment Committee --- p.i<br>Acknowledgement --- p.ii<br>Abstract (English) --- p.iii<br>Abstract (Chinese) --- p.v<br>List of Abbreviations --- p.vii<br>List of Tables --- p.ix<br>List of Figures --- p.x<br>Chapter Chanter 1 --- Introduction<br>Chapter 1.1. --- Overview of cancer --- p.1<br>Chapter 1.1.1 --- Breast cancer --- p.1<br>Chapter 1.1.2 --- Hepatocellular carcinoma (HCC) --- p.2<br>Chapter 1

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29

"Immunomodulatory and anti-tumor polysaccharides from pseudostellaria heterophylla." Chinese University of Hong Kong, 1993. http://library.cuhk.edu.hk/record=b5895760.

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by Wong Chun-kwok.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1993.<br>Includes bibliographical references (leaves 233-246).<br>ABSTRACT --- p.I<br>ACKNOWLEDGEMENTS --- p.V<br>ABBREVIATIONS --- p.VI<br>PUBLICATIONS --- p.IX<br>CHAPTER<br>Chapter 1. --- GENERAL INTRODUCTION --- p.1<br>Chapter 1.1 --- EFFECTOR CELLS MEDIATING ANTI一TUMOR IMMUNITY --- p.3<br>Chapter 1.1.1 --- CYTOTOXIC T LYMPHOCYTES --- p.4<br>Chapter 1.1.2 --- MACROPHAGES --- p.4<br>Chapter 1.1.3 --- NATURAL KILLER CELLS --- p.5<br>Chapter 1.1.4 --- LYMPHOKINE ACTIVATED KILLER CELLS --- p.7<br>Chapter 1.1.5 ---

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30

"Immunomodulatory and anti-tumor effects of klebsiella K24 capsular polysaccharide." 1997. http://library.cuhk.edu.hk/record=b5889129.

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by Chen Paul.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1997.<br>Includes bibliographical references (leaves 141-150).<br>Chapter 1. --- INTRODUCTION --- p.1<br>Chapter 1.1 --- Immunomodulation --- p.1<br>Chapter 1.2 --- Effector cells mediating anti-tumour immunity --- p.1<br>Chapter 1.2.1 --- Cytotoxic T Lymphocytes --- p.3<br>Chapter 1.2.2 --- Macrophages --- p.4<br>Chapter 1.2.3 --- Natural Killer Cells --- p.5<br>Chapter 1.2.4 --- Lymphokine-activated Killer (LAK) --- p.6<br>Chapter 1.3 --- Cytokines as immunomodulators in cancer therapy --- p.7<br>Chapter 1.3.1 --- Tu

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31

"The anti-tumor mechanism of PPAR[gamma] activator troglitazone in human lung cancer." Thesis, 2006. http://library.cuhk.edu.hk/record=b6074120.

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In conclusion, our study has demonstrated that TGZ, a synthetic PPARgamma ligand, inhibits lung cancer cells growth through cell-cycle arrest, increased cell differentiation and induction of apoptosis. In this pathway, the activation of ERK by TGZ plays a central role in promoting apoptosis, which appears to be mediated via a mitochondria-related mechanism and functions in a PPARgamma-dependent manner. The interaction between PPARgamma and ERK may create an auto-regulatory and positive feedback loop to enhance the effect of ERK whereas the activation of Akt may generate a negative regulation t

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32

"Studies on the anti-tumor effects of cytokinins on myeloid leukemia cells." 2006. http://library.cuhk.edu.hk/record=b5892904.

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Yau Wai Lok.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2006.<br>Includes bibliographical references (leaves 195-205).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGEMENTS --- p.i<br>ABBREVIATIONS --- p.ii<br>ABSTRACT --- p.vii<br>撮要 --- p.x<br>PUBLICATIONS --- p.xii<br>TABLE OF CONTENTS --- p.xiii<br>Chapter CHAPTER 1: --- GENERAL INTRODUCTION<br>Chapter 1.1 --- Hematopoiesis & Leukemia --- p.1<br>Chapter 1.1.1 --- An Overview on Hematopoiesis --- p.1<br>Chapter 1.1.2 --- An Overview of Leukemia --- p.4<br>Chapter 1.1.2.2 --- Classification and Epidemiology of Leukemia

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Rakoma, Mamphago Annah. "Screening methanolic extracts of Sutherlandia spp as anti-tumor agents and their effects on anti-apoptotic genes." Diss., 2016. http://hdl.handle.net/10500/20675.

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Cervical cancer is the most common malignancy after breast cancer in women worldwide. It accounts for 83% of all new cases and 85% cancer death in developing countries. In South Africa, cervical cancer is the common cancer in women with an annual crude incidence rate of 30.2 per 100,000 women and the highest rate were found to be in women between the ages of 66-69 years. Approximately 6800 women in S.A face new case of cervical cancer while accounting for 3700 cancer death annually. Because of unequal access to the health facilities, socio-economic differences, HPV and HIV infection, the rate

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Chang, Chih-Hsiang, and 張至翔. "Synthesis and Biological Evaluation of Novel Series Chalcone Analogues as Anti-tumor Agents." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/46538800806153619937.

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碩士<br>國立嘉義大學<br>生物醫藥科學研究所<br>97<br>Chalcones (1, 3-diphenyl-2-propenone) are cancer preventive food components found in a human diet rich in fruits and vegetables. Besides, chalcones are known to exhibit antimitotic properties caused by inhibition of tubulin polymerization by binding to the colchicine-binding site. Its structure is similar to colchicine and combretastatin A-4 (CA-4). It has extensive cytotoxic activity in many human cancer cell lines, including prostate carcinoma, colon carcinoma, and lung carcinoma. Chalcones are well-known to exhibit antimitotic properties caused by inhibiti

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"Studies on the anti-tumor effects and action mechanisms of fluvastatin on murine myeloid leukemia cells." 2010. http://library.cuhk.edu.hk/record=b5894400.

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Chin, Chi Hou.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2010.<br>Includes bibliographical references (leaves [165]-178).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>Abstract in Chinese (摘要） --- p.iv<br>Acknowledgements --- p.vi<br>Abbreviations --- p.vii<br>List of Figures and Tables --- p.xi<br>Publications --- p.xv<br>Chapter Chapter 1 --- General Introduction<br>Chapter 1.1. --- Hematopoiesis and Leukemia --- p.2<br>Chapter 1.1.1. --- Hematopoiesis --- p.2<br>Chapter 1.1.2. --- Leukemia --- p.8<br>Chapter 1.1.2.1. --- Overview of leukemia --- p.8<br>Ch

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Hu, Zhi-Qiang, and 胡志強. "The synthesis of indirubin derivatives of chronic myelocytic leukemia as potential anti-tumor agents." Thesis, 1988. http://ndltd.ncl.edu.tw/handle/83800102889401850763.

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"Study of anti-tumor and immunomodulatory activities of two annonaceous acetogenins: microcarpacin A and microcarpacin B." 2004. http://library.cuhk.edu.hk/record=b6073683.

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Wu Xiujuan.<br>"May 2004."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2004.<br>Includes bibliographical references (p. 294-314).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.<br>Abstracts in English and Chinese.

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Tsai, Yun Zhan, and 蔡昀真. "Synthesis and evaluation of 5-Nitrobenzamide derivatives as anti-tumor cells-induced platelet aggregation agents." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/j32zg7.

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"Studies on the anti-tumor activities and action mechanisms of banlangen alkaloids on human neuroblastoma cells." 2013. http://library.cuhk.edu.hk/record=b5549812.

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神經母細胞瘤是一種交感神經系統的腫瘤。它是最常見的兒童顱外實體瘤。神經母細胞瘤約佔兒童腫瘤的8-10%，佔15%的兒童腫瘤死亡率。目前神經母細胞瘤的治療方法包括外科手術，化學藥物治療，放射治療，幹細胞移植，誘導分化治療和免疫治療。然而，這些治療方法通常會導致許多無法避免的嚴重的副作用。因此，開發能高效抑制神經母細胞瘤但對正常細胞無明顯副作用的新型藥物顯得至關重要。最近，用來源於天然產物或中藥的化合物治療癌症引起了科學家的廣泛關注。靛玉紅-3’-肟（Indirubin-3’-oxime, I3M）和色胺酮（tryptanthrin）分別是從板藍根中分離得到的靛藍生物鹼和吲哚喹唑啉類生物鹼。據研究報導，這兩種生物鹼具有多種生物學和藥理學作用，包括抗菌，抗炎症和抗腫瘤作用。它們對體外的多種人腫瘤細胞具有抗腫瘤作用。然而，它們對人神經母細胞瘤的調節作用和作用機理仍不太清楚。在我的博士研究課題中，我們對板藍根生物鹼包括靛玉紅-3’-肟和色胺酮對人神經母細胞瘤的抗腫瘤活性和作用機制進行了研究和探討。<br>首先，我們研究了靛玉紅-3’-肟對人神經母細胞瘤的抗腫瘤活性和作用機制。實驗結果表明，靛玉紅-3’-肟能夠抑制人神經母細胞瘤LA-N-1, SH-SY5Y 和 SK-N-DZ細胞系的生長，並且其抑制效果呈時間和濃度依賴性。然而，靛玉紅-3’-肟對正常細胞無顯著的細胞毒性作用。對其生

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"A study of the biological activities of cordyceps militaris and the action mechanisms of the anti-tumor effect of cordycepin." 2003. http://library.cuhk.edu.hk/record=b5891714.

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by Lee Kin Ming.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 214-225).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGEMENTS --- p.i<br>ABBREVIATIONS --- p.ii<br>ABSTRACT --- p.vii<br>ABSTRACT IN CHINESE --- p.ix<br>LIST OF FIGURES --- p.xi<br>LIST OF TABLES --- p.xv<br>CONTENTS --- p.xvi<br>Chapter CHAPTER 1: --- INTRODUCTION --- p.1<br>Chapter 1.1 --- Cordyceps --- p.2<br>Chapter 1.1.1 --- Pharmacological Functions of Cordyceps --- p.5<br>Chapter 1.1.1.1 --- Anti-tumor Activities --- p.5<br>Chapter 1.1.1.2 --- Immun

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Fennell, Kelley Ann. "Synthesis and studies of amamistatin B and analogs as potential mycobacterial growth inhibitors and anti-tumor agents." 2007. http://etd.nd.edu/ETD-db/theses/available/etd-04202007-151822/.

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Thesis (Ph. D.)--University of Notre Dame, 2007.<br>Thesis directed by Marvin J. Miller for the Department of Chemistry and Biochemistry. "April 2007." Includes bibliographical references (leaves 214-221).

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Lin, Yang-Sheng, and 林揚笙. "Systematic Review and Meta-analysis: Risk of Post-Operative Complications Associated with Anti-Tumor Necrosis Factor Agents for Crohn''s disease." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/2z5uw8.

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Espadinha, Margarida Leonor Florindo. "Enantiopure bicyclic lactams: synthesis and biological evaluation." Master's thesis, 2015. http://hdl.handle.net/10362/25154.

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N-Methyl-D-Aspartate (NMDA) receptors are fundamental for the normal function of the central nervous system and have an important role in memory and learning. An overactivation of these receptors results into an influx of excess of calcium cation (Ca2+) leading to neuronal loss associated with major degenerative disorders including Parkinson’s and Alzheimer’s diseases. Since the 80s, a big interest emerged of both academia and industry to develop drugs targeting the NMDA subtype of glutamate receptors with potential application for the treatment of some degenerative disorders. The main success

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