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Bursill, Christina. "Green tea and its catechins modulate cholesterol metabolism in cultured human liver (HepG2) cells and the hypercholesterolaemic rabbit." Title page, contents and introduction only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09pdb9725.pdf.
Includes bibliographical references (21 leaves). Previous studies have found that green tea and its antitoxidant constituents, the catechins, are hypocholesterolaemic in both epidemiological and animal intervetion studies. The main objectives of the present study were to investigate the mechanism by which green tea and its most abundant catechin constituent epigallocatechin gallate increase the low-density lipoprotein (LDL) receptor of HepG2 cells. In addition, it was hoped to determine if a crude catechin extract from green tea could lower plasma cholesterol levels in the hypercholesterolaemic rabbit and ascertain if this effect was due to an increase in the LDL receptor. The study provides evidence that green tea and its catechins exhibit hypocholesterolaemic properties and may therefore provide protection against heart disease.
Marinangeli, Christopher P. F. "The composition, biological trafficking and cholesterol-lowering efficacy of sugarcane-derived policosanol supplements /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99351.
The cholesterol-lowering efficacy of the original sugarcane-derived Cuban policosanol (OPC) supplement has been attributed to an exclusive policosanol purity and composition. The first objective of the following study was to compare the purity and composition of the OPC and alternative sugarcane derived policosanol (APC) products. Second, to measure blood lipids and policosanol levels in tissues, plasma and feces in hamsters receiving diet fortified with no policosanols, OPC, or an APC (APC1) product. Results indicated that the policosanol purity and composition of the OPC and APC formulations are similar. Lipid levels were not significantly different between groups. Policosanols were undetectable in the plasma and tissues of any animals following policosanol supplementation. Policosanols were excreted at a higher rate in animals consuming APC1. Sugarcane-derived policosanols are not an efficacious cholesterol-lowering therapy. The purity and relative percent composition of the OPC supplement cannot account for its efficacy as a lipid lowering agent.
Xiu, Jin. "Distribution and function of nicotinic acetylcholine receptors in glia cells and neurons with focus on the neuroprotective mechanisms of cholesterol-lowering drugs in Alzheimer's disease /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-758-8/.
Eno, Megan. "The effect of the supplementation of cranberry seed oil on the lipid profiles of human subjects." Menomonie, WI : University of Wisconsin--Stout, 2007. http://www.uwstout.edu/lib/thesis/2007/2007enom.pdf.
Chapman, Laurie. "In vitro hypocholesterolemic potential of dietary additives used by the Batemi and Maasai people : (Hypocholesterolemic potential of additives from a traditional diet)." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22725.
Dietary phytochemicals such as saponins have been suggested to have therapeutic uses in the prevention and alleviation of hypercholesterolemia. Thus, twelve Tanzanian plant additives hypothesized to contain saponins and used in soup by the Batemi, were investigated for in vitro hypocholesterolemic potential by: (1) screening for likelihood of detectable saponins using TLC, hemolysis, frothing ability and molluscicidal activity. (2) using changes in hemolytic activity to indirectly examine interactions of plant extracts with cholesterol, cholesterol-analogues, conjugated bile salts and non-conjugated bile salts. (3) using radiolabelled cholesterol to examine direct binding capacity of extracts with cholesterol. Albizia anthelmintica, Myrsine africana and Acacia goetzii were most likely to contain saponins and had significant (p $<$ 0.05) hemolytic activity that was effected by the presence of cholesterol, cholesterol analogues, conjugated and non-conjugated bile salts (p $<$ 0.05). Methanol, ethyl acetate, aqueous and n-butanol extracts of A. anthelmintica and methanol, ethyl acetate and aqueous extracts of A. goetzii bound significant amounts of cholesterol solubilized in ethanol (p $<$ 0.05). Thus, saponins are a detectable component of the Batemi diet and extracts likely containing saponins do interact with chemicals that have been proposed to be involved in in vivo mechanisms of saponin induced hypocholesterolemia. A. anthelmintica and A. goetzii seem likely to have hypocholesterolemic potential as dietary additives.
Tam, Hoi-ling. "Soluble receptors for advanced glycation end products in type 2 diabetes mellitus." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43572182.
Boudreau, Denise M. "The association between HMG-CoA inhibitor use and breast cancer risk & a validation study of patient interview data and pharmacy records for antihypertensive, statin, and antidepressant medication use /." Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/7934.
P, Beck J., Crastes de Paulet A, and Institut national de la santé et de la recherche médicale (France), eds. Activités biologiques des oxystérols: Séminaire de recherche INSERM, Mittelwihr, 7-9 octobre 1987. Paris: Editions INSERM, 1988.