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Статті в журналах з теми "Antimitotic Activity"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Sundaresan, K., M. Thangavel, and K. Tharini. "Synthesis, characterization and antimitotic activity of N-benzyl piperidin 4-one oxime." Journal of Drug Delivery and Therapeutics 9, no. 1 (2019): 233–36. http://dx.doi.org/10.22270/jddt.v9i1.2228.

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Анотація:

The aim of this study was to synthesize, characterization and antimitotic activity of N-Benzyl piperidin 4-one oxime derivative. The synthesized compound was characterized by IR, 13C and 1H NMR spectral studies. The synthesized compound was subjected to antimitotic studies of alliumcepa root meristamatic cells. The mitotic activity was observed in 3 different concentrations of N-Benzyl piperidin 4-one oxime. Our findings support the reported therapeutic use of this compound as a antimitotic or anticancer agent in the Indian system of medicine. Keywords: N-Benzyl piperidin 4-one oxime, me

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2

R. A. Ahirrao, B. S. Patange, and S. V. More. "Evaluation of Antimitotic Activity of Momordica Dioica Fruits on Allium Cepa Root Meristamatic Cells." Journal of Pharmaceutical Technology, Research and Management 7, no. 2 (2019): 67–71. http://dx.doi.org/10.15415/jptrm.2019.72009.

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Objective: Natural occurring phenolic compounds play an important role in cancer prevention and shows antimitotic activity. Number of active constituents like phenolic acid, curcuminoids, coumarine, ligans, quinones, etc. is showing antimitotic activity of Momordica dioica. The present work is on phytochemical investigation and examines antimitotic activity of aqueous extract of fruits Momordica dioica at concentration of 15 mg/ml on Allium cepa root meristamatic cells.Methods: The fruits are air dried and extracted with solvents like water by maceration method. The evaluation of antimitotic a

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3

Groult, Hugo, Isabel García-Álvarez, Lorenzo Romero-Ramírez, et al. "Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides." Nanomaterials 8, no. 8 (2018): 567. http://dx.doi.org/10.3390/nano8080567.

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The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive

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4

Badria, Farid A., Waell E. Houssein, Mona G. Zaghloul, and Ahmed F. Halim. "Antimitotic Activity of Gossypol and Gossypolone." Pharmaceutical Biology 39, no. 2 (2001): 120–26. http://dx.doi.org/10.1076/phbi.39.2.120.6257.

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5

Zhai, Lei, Anushree Balachandran, Rebecca Larkin, et al. "Mitotic Dysregulation at Tumor Initiation Creates a Therapeutic Vulnerability to Combination Anti-Mitotic and Pro-Apoptotic Agents for MYCN-Driven Neuroblastoma." International Journal of Molecular Sciences 24, no. 21 (2023): 15571. http://dx.doi.org/10.3390/ijms242115571.

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MYCN amplification occurs in approximately 20–30% of neuroblastoma patients and correlates with poor prognosis. The TH-MYCN transgenic mouse model mimics the development of human high-risk neuroblastoma and provides strong evidence for the oncogenic function of MYCN. In this study, we identified mitotic dysregulation as a hallmark of tumor initiation in the pre-cancerous ganglia from TH-MYCN mice that persists through tumor progression. Single-cell quantitative-PCR of coeliac ganglia from 10-day-old TH-MYCN mice revealed overexpression of mitotic genes in a subpopulation of premalignant neurob

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6

Mohan, Gottumukkala Krishna, Malavika Yadav, M. Sandhya Rani, and Kalakotla Shanker. "Antimitotic activity of Borassus flabellifer Seed Coat." Research Journal of Pharmacognosy and Phytochemistry 8, no. 4 (2016): 223. http://dx.doi.org/10.5958/0975-4385.2016.00033.9.

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7

Satish, Ponnada* Bhagyalaxmi Suvvari. "Synthesis And Antimitotic Activity of Benzotriazole Compound." International Journal of Pharmaceutical Sciences 3, no. 4 (2025): 2932–37. https://doi.org/10.5281/zenodo.15273474.

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Анотація:

The present work to Synthesize benzotriazole Nucleus and study the biological activity of Antimitotic method through by seed germination assay by using the green gram seeds. It is preliminary screening method to identify this benzotriazole basic nucleus is having Anticancer property. By using this seed germination assay method be can studied that this nucleus is having inhibition of seed germination Activity.

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8

Ramos, Sergio, Alba Vicente-Blázquez, Marta López-Rubio, Laura Gallego-Yerga, Raquel Álvarez, and Rafael Peláez. "Frentizole, a Nontoxic Immunosuppressive Drug, and Its Analogs Display Antitumor Activity via Tubulin Inhibition." International Journal of Molecular Sciences 24, no. 24 (2023): 17474. http://dx.doi.org/10.3390/ijms242417474.

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Antimitotic agents are one of the more successful types of anticancer drugs, but they suffer from toxicity and resistance. The application of approved drugs to new indications (i.e., drug repurposing) is a promising strategy for the development of new drugs. It relies on finding pattern similarities: drug effects to other drugs or conditions, similar toxicities, or structural similarity. Here, we recursively searched a database of approved drugs for structural similarity to several antimitotic agents binding to a specific site of tubulin, with the expectation of finding structures that could f

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9

Podila, Naresh, Mithun Rudrapal, Subramanyam Sibbala, et al. "In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues." Pharmacia 70, no. (4) (2023): 887–94. https://doi.org/10.3897/pharmacia.70.e109898.

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Анотація:

In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazolo-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazolo-benzothiazole analogues in inhibiting the proliferation of cancer cells ei

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10

Reethu Metilda Manukonda and Satapathy Dhabal. "Phytochemical Analysis and Evaluation of In Vitro Antimitotic Activity of Allamanda cathartica Methanolic Extract." Journal of Pharma Insights and Research 2, no. 4 (2024): 146–54. http://dx.doi.org/10.69613/92x5vg75.

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Allamanda cathartica, a perennial shrub of the Apocynaceae family, has garnered significant attention in pharmacological research due to its diverse bioactive compounds and potential therapeutic applications. This study aimed to investigate the phytochemical composition and evaluate the in vitro antimitotic activity of A. cathartica methanolic extract. Comprehensive phytochemical screening revealed the presence of carbohydrates, alkaloids, saponin glycosides, proteins, tannins, flavonoids, and amino acids in the extract. The antimitotic potential was assessed using a seed germination assay wit

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11

Shivasharanappa, Kirankumar, and Ramesh Londonkar. "Clot Lysis and Antimitotic Study of Ficus glomerata Roxb Fruit Extracts." ISRN Pharmacology 2014 (March 31, 2014): 1–4. http://dx.doi.org/10.1155/2014/975303.

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The present study was carried out to investigate the thrombolytic and antimitotic potentiality of various extracts of fruits of Ficus glomerata, a traditional medicinal plant, using an in vitro assay method. Three crude extracts such as petroleum ether (FGPE), chloroform (FGCE), and methanol (FGME) were used for the study, with a standard (streptokinase) and negative control (sterile distilled water) to validate the method. The thrombolytic nature of the plant was found significant with methanol extract and chloroform and petroleum ether extracts have recorded mild activity, when compared with

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12

Podila, Naresh, Mithun Rudrapal, Subramanyam Sibbala, et al. "In vitro antimitotic activity and in silico study of some 6-fluoro-triazolo-benzothiazole analogues." Pharmacia 70, no. 4 (2023): 887–94. http://dx.doi.org/10.3897/pharmacia.70.e109898.

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Анотація:

In this work, nine 6-fluoro-triazolo-benzothiazole derivatives were prepared and evaluated for in vitro antimitotic activity. In addition, in silico study was also done using tubulin protein (PDB: 6QQN) by molecular docking method. Results revealed that TZ2 and TZ9 were the most active compounds with antimitotic action opposing the standard drug, aspirin. Results of molecular docking exhibited the inhibitory potential of triazolo-benzothiazole against tubulin protein. The mitotic study indicates the efficacy of triazolo-benzothiazole analogues in inhibiting the proliferation of cancer cells ei

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13

Nieman, James A., John E. Coleman, Debra J. Wallace, et al. "Synthesis and Antimitotic/Cytotoxic Activity of Hemiasterlin Analogues." Journal of Natural Products 66, no. 2 (2003): 183–99. http://dx.doi.org/10.1021/np020375t.

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14

Pinto, Bárbara, Pedro Novais, Ana C. Henriques, Juliana Carvalho-Tavares, Patrícia M. A. Silva, and Hassan Bousbaa. "Navitoclax Enhances the Therapeutic Effects of PLK1 Targeting on Lung Cancer Cells in 2D and 3D Culture Systems." Pharmaceutics 14, no. 6 (2022): 1209. http://dx.doi.org/10.3390/pharmaceutics14061209.

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The efficacy of antimitotics is limited by slippage, whereby treated cells arrested in mitosis exit mitosis without cell division and, eventually, escape apoptosis, constituting a serious resistance mechanism to antimitotics. Strategies to overcome slippage should potentiate the cancer cell killing activity of these antimitotics. Such strategies should accelerate cell death in mitosis before slippage. Here, we undertook a mechanistic analysis to test whether the apoptosis activator Navitoclax potentiates apoptosis triggered by the antimitotic BI2536, a potent inhibitor of Polo-like kinase 1 (P

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15

Prathamanjali, S., Y. T. Rajesh Babu, and T. Vijaya. "<i>In vitro </i>assessment of antimitotic, antiproliferative and anticancer activities of different sections of <i>Cleistanthus collinus</i> (Roxb.) Benth. Ex. Hook. F." Journal of Applied and Natural Science 17, no. 1 (2025): 407–20. https://doi.org/10.31018/jans.v17i1.6324.

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Natural-derived chemicals, particularly secondary metabolites from plants, are gaining attention for their potential as innovative and less harmful anticancer treatments, advancing cancer therapy and developing new medicinal herbs. The present study aimed to investigate the antimitotic, antiproliferative, and anticancer activities of various extracts from the leaves, bark, and fruits of Cleistanthus collinus using the Allium cepa root tip assay, yeast cell model, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay against Henrietta Lacks (HeLa) and Michigan Cancer Foun

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16

Riaz, Sharon, Khalid Mohammed Khan, Ghayoor Abbas Chotana, Amir Faisal, and Rahman Shah Zaib Saleem. "The Antimitotic Podophyllotoxin and its Derivatives Recent Synthetic Advances." Current Nutraceuticals 3, no. 1 (2022): 4–37. http://dx.doi.org/10.2174/2665978602666211102103152.

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: The substantial antimitotic potential of podophyllotoxin and its derivatives has attracted both synthetic and medicinal chemists to expand the chemical space for the subsequent biological evaluation of these compounds. The interest ranges from total synthesis, hemi-synthesis, one-pot synthetic approaches and structure-activity relationship studies. In the first segment of the review, we present recent development in the synthesis of podophyllotoxin and also describe its mode of action. the second section covers the synthesis and the structure-activity relationships of podophyllotoxin derivat

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17

Novais, Pedro, Patrícia M. A. Silva, Joana Moreira, et al. "BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity." Molecules 26, no. 23 (2021): 7139. http://dx.doi.org/10.3390/molecules26237139.

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Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitos

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18

Temple, Carroll, Gregory A. Rener, William R. Waud, and Patricia E. Noker. "Antimitotic agents: structure-activity studies with some pyridine derivatives." Journal of Medicinal Chemistry 35, no. 20 (1992): 3686–90. http://dx.doi.org/10.1021/jm00098a014.

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19

Rao, Pemmaraju N., James W. Cessac, Tina L. Tinley, and Susan L. Mooberry. "Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs." Steroids 67, no. 13-14 (2002): 1079–89. http://dx.doi.org/10.1016/s0039-128x(02)00066-1.

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20

López-Donaire, M. L., J. Parra-Cáceres, M. Fernández-Gutiérrez, B. Vázquez-Lasa, and J. San Román. "Polymeric Drugs Based on Random Copolymers with Antimitotic Activity." Biomacromolecules 11, no. 9 (2010): 2478–86. http://dx.doi.org/10.1021/bm100672c.

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21

Morita, Hiroshi, Tomoka Dota, and Jun'ichi Kobayashi. "Antimitotic activity of glaupalol-related coumarins from Glaucidium palmatum." Bioorganic & Medicinal Chemistry Letters 14, no. 14 (2004): 3665–68. http://dx.doi.org/10.1016/j.bmcl.2004.05.015.

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22

Kibrik, B. S., I. M. Prokhorova, and D. S. Pesnya. "Mutagenic and antimitotic activity of the immunomodulatory drug tubosan." Pharmaceutical Chemistry Journal 47, no. 5 (2013): 261–63. http://dx.doi.org/10.1007/s11094-013-0941-2.

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23

Magalhães, Hemerson I. F., Paulo M. P. Ferreira, Eraldo S. Moura, et al. "In vitro and in vivo antiproliferative activity of Calotropis procera stem extracts." Anais da Academia Brasileira de Ciências 82, no. 2 (2010): 407–16. http://dx.doi.org/10.1590/s0001-37652010000200017.

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Анотація:

The cytotoxic potential of stem organic extracts from Calotropis procera (Asclepiadaceae) was firstly evaluated against cancer cell lines by MTT assay. Subsequently, samples considered cytotoxic were tested for antimitotic activity on sea urchin egg development and for in vivo antiproliferative activity in mice bearing Sarcoma 180 tumor. Among the five extracts (hexane, dichloromethane, ethyl acetate, acetone and methanol), ethyl acetate and acetone extracts displayed higher cytotoxic potential against tumor cells, with IC50 ranging from 0.8 to 4.4 μg/mL, while methanolic extract was weakly cy

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24

Kanthal, Lakshmi Kanta, Suman Pattanayak, Susmita Roy, et al. "Anti-mitotic Activity of Methanolic Extract of Thevetia peruviana fruits." Journal of Drug Delivery and Therapeutics 14, no. 5 (2024): 44–48. http://dx.doi.org/10.22270/jddt.v14i5.6531.

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Thevetia peruviana plant, a member of the Apocynaceae family, has a long history in traditional medicine for treating various ailments such as amenorrhea, malaria, jaundice, hemorrhoids, constipation, headaches, and skin issues. It contains significant amounts of cardiac glycosides in both its roots and seeds, which are known for their cytotoxic effects similar to digoxin. Given its potential toxicity and widespread use, current research is focused on assessing the antimitotic properties of the methanolic extract derived from the fruits of Thevetia peruviana. In the pursuit of potential pharma

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25

Lee, Ji Sun, Yunmoon Oh, Jae Hyeon Park, So Young Kyung, Hyung Sik Kim, and Sungpil Yoon. "Terconazole, an Azole Antifungal Drug, Increases Cytotoxicity in Antimitotic Drug-Treated Resistant Cancer Cells with Substrate-Specific P-gp Inhibitory Activity." International Journal of Molecular Sciences 23, no. 22 (2022): 13809. http://dx.doi.org/10.3390/ijms232213809.

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Azole antifungal drugs have been shown to enhance the cytotoxicity of antimitotic drugs in P-glycoprotein (P-gp)-overexpressing-resistant cancer cells. Herein, we examined two azole antifungal drugs, terconazole (TCZ) and butoconazole (BTZ), previously unexplored in resistant cancers. We found that both TCZ and BTZ increased cytotoxicity in vincristine (VIC)-treated P-gp-overexpressing drug-resistant KBV20C cancer cells. Following detailed analysis, low-dose VIC + TCZ exerted higher cytotoxicity than co-treatment with VIC + BTZ. Furthermore, we found that VIC + TCZ could increase apoptosis and

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26

Hu, Laixing, Jian-dong Jiang, Jinrong Qu, et al. "Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure–activity relationships." Bioorganic & Medicinal Chemistry Letters 17, no. 13 (2007): 3613–17. http://dx.doi.org/10.1016/j.bmcl.2007.04.048.

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27

Satish, Ponnada* Tompala Bhavani Tulugu Mounika Varanasi Swetha Janaki Palla Seela Likitha Pothulua John Benny. "Phytochemical Screening and Biological Evalution OF Daucus Carota Root & Stem Extracts." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1890–905. https://doi.org/10.5281/zenodo.15055071.

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The present work to evaluate the phytochemical screening and biological evalution of Daucus carato root and stem extracts. we done screening for antimitotic and antibacterial activities. The extracts of this plant also found applications in many of the traditional medicines. The antibacterial activities were assay of organic extract of Daucus carota root & stem. Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were evaluated using standard microbiological techniques. They showed a high significant antibacterial activity using microorganisms such as Bacill

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28

Guenard, Daniel, Francoise Gueritte-Voegelein, and Francois Lavelle. "Taxoids: A New Class of Antimitotic Compounds." Current Pharmaceutical Design 1, no. 1 (1995): 95–112. http://dx.doi.org/10.2174/1381612801666220524192845.

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Paclitaxel (Taxol®) and docetaxel (Taxotere®) are the first representatives of taxoids , a new class of antitumor compounds. These two taxoids are clinically active against breast, ovarian and lung cancers. Taxoids are highly complex diterpenoids from natural origin. Preclinical and clinical develop-ments have been made possible after a long and sustained chemical effort : paclitaxel is extracted from the barks of the Pacific yew tree Taxus brevifolia whereas docetaxel is prepared by hemisynthesis starting from 10-deacetyl-baccatin ill, a non cytotoxic precursor found in the needles of the Eur

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29

Chen, Xing, Shi-Meng Wang, Gajjela Bharath Kumar, et al. "Recent Developments on Phenstatins as Potent Antimitotic Agents." Current Medicinal Chemistry 25, no. 20 (2018): 2329–52. http://dx.doi.org/10.2174/0929867324666171106162048.

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Background: Phenstatin and their derivatives display remarkable antiproliferative activity toward a wide variety of preclinical tumor models. Structural simplicity and excellent stability of phenstatins offer a stimulating premise for developing various derivatives with profound antimitotic activity and excellent cytotoxicity. Objective: To do analysis of literature that phenstatins derivatives inhibit tubulin polymerization through their interaction at the colchicine binding site of microtubules and arrest the G2/M phase of the cell cycle. In addition, phenstatin derivatives are undergoing cl

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30

Gayathri Karthikeyan, Geetha RV, and Lakshmi Thangavelu. "Antimitotic activity of Piper nigrum on clinical isolates of candida." International Journal of Research in Pharmaceutical Sciences 10, no. 2 (2019): 1167–71. http://dx.doi.org/10.26452/ijrps.v10i2.400.

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The objective of this study is to analyse the antimycotic activity of pepper on the clinical isolates of Candida. The extracts were prepared in the following concentrations in sterile water. 5mg/ml and 10mg/ml and 20mg/ml. 100µl of an extract of different concentrations were loaded on sterile filter paper discs measuring 6mm in diameter, so that the concentration of the extract on each disc was 500µg, 1000 µg and 2000µg respectively. The discs were dried and kept aseptically. Screening of antifungal activity [dis diffusion technique] The ethanolic extract of Piper nigrum was screened for antif

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31

Sivakumar, Ponnurengam Malliappan, Naga Vignesh, Gopal Ramesh Kumar, and Mukesh Doble. "Computational approaches to enhance activity of taxanes as antimitotic agent." Medicinal Chemistry Research 21, no. 9 (2011): 2557–70. http://dx.doi.org/10.1007/s00044-011-9779-x.

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32

Boumendjel, Ahcène, Julien Boccard, Pierre-Alain Carrupt, et al. "Antimitotic and Antiproliferative Activities of Chalcones: Forward Structure–Activity Relationship." Journal of Medicinal Chemistry 51, no. 7 (2008): 2307–10. http://dx.doi.org/10.1021/jm0708331.

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33

Simon-Levert, Annabel, Antoine Aze, Nataly Bontemps-Subielos, Bernard Banaigs, and Anne-Marie Genevière. "Antimitotic activity of methoxyconidiol, a meroterpene isolated from an ascidian." Chemico-Biological Interactions 168, no. 2 (2007): 106–16. http://dx.doi.org/10.1016/j.cbi.2007.03.004.

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34

Lee, Hsueh-Yun, Chih-Yi Chang, Mei-Jung Lai, et al. "Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes." Bioorganic & Medicinal Chemistry 23, no. 15 (2015): 4230–36. http://dx.doi.org/10.1016/j.bmc.2015.06.043.

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35

Olson, Oakley C., Hyunjung Kim, Daniela F. Quail, Emily A. Foley, and Johanna A. Joyce. "Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents." Cell Reports 19, no. 1 (2017): 101–13. http://dx.doi.org/10.1016/j.celrep.2017.03.038.

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36

Chaitramallu, M1 Devaraju Kesagodu1 Dakshayini Chandrashekarachar2. "SYNTHESIS AND BIOLOGICAL SCREENING OF ANALOGS OF ARYL TETRALONE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH 07, no. 01 (2017): 7392–98. https://doi.org/10.5281/zenodo.1006777.

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Анотація:

The aryl tetralone as potential antimitotic agents were synthesized in four step reactions using Grignard reagent. The first step is the synthesis of trimethoxy phenyl naphthol (2a-f) by the reaction of substituted tetralone with 3, 4, 5-trimethoxy 1-bromobenzene in magnesium metal using tetrahydrofuran as a solvent. The resulted phenyl naphthol was hydrogenated to give phenyl tetralin 3(a-f). The substituted phenyl tetralone were prepared by the oxidation of trimethoxy phenyl tetralin 4(a-f). The structures of the synthesized compounds were confirmed by spectral and elemental analysis data. T

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37

Obbalareddy, Satya, Prabhanjan Kumar Kolli, Rajendra Prasad Yejella, Satish Ponnada, and Lalitha Devi Athili. "PHYTOCHEMICAL SCREENING, ANTIOXIDANT ACTIVITY, ANTI-INFLAMMATORY ACTIVITY ANTIMITOTIC ACTIVITY AND POTENTIAL OF TEPHROSIA MAXIMA PODS." International Journal of Research in Pharmacy and Chemistry 12, no. 3 (2022): 36. http://dx.doi.org/10.33289/ijrpc.12.3.2022.12(36).

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38

Moreira, Joana, Patrícia M. A. Silva, Eliseba Castro, et al. "BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity." International Journal of Molecular Sciences 25, no. 3 (2024): 1691. http://dx.doi.org/10.3390/ijms25031691.

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Анотація:

Recently, the diarylpentanoid BP-M345 (5) has been identified as a potent in vitro growth inhibitor of cancer cells, with a GI50 value between 0.17 and 0.45 µM, showing low toxicity in non-tumor cells. BP-M345 (5) promotes mitotic arrest by interfering with mitotic spindle assembly, leading to apoptotic cell death. Following on from our previous work, we designed and synthesized a library of BP-M345 (5) analogs and evaluated the cell growth inhibitory activity of three human cancer cell lines within this library in order to perform structure–activity relationship (SAR) studies and to obtain co

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39

França, Fábio, Patrícia M. A. Silva, José X. Soares, et al. "A Pyranoxanthone as a Potent Antimitotic and Sensitizer of Cancer Cells to Low Doses of Paclitaxel." Molecules 25, no. 24 (2020): 5845. http://dx.doi.org/10.3390/molecules25245845.

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Microtubule-targeting agents (MTAs) remain a gold standard for the treatment of several cancer types. By interfering with microtubules dynamic, MTAs induce a mitotic arrest followed by cell death. This antimitotic activity of MTAs is dependent on the spindle assembly checkpoint (SAC), which monitors the integrity of the mitotic spindle and proper chromosome attachments to microtubules in order to ensure accurate chromosome segregation and timely anaphase onset. However, the cytotoxic activity of MTAs is restrained by drug resistance and/or toxicities, and had motivated the search for new compo

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40

Daly, Erin M., and Richard E. Taylor. "Entropy and Enthalpy in the Activity of Tubulin-Based Antimitotic Agents." Current Chemical Biology 3, no. 1 (2009): 367–79. http://dx.doi.org/10.2174/187231309787158244.

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41

Taylor, Richard, and Erin Daly. "Entropy and Enthalpy in the Activity of Tubulin-Based Antimitotic Agents." Current Chemical Biology 3, no. 1 (2009): 47–59. http://dx.doi.org/10.2174/2212796810903010047.

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Basavaraju, YB, B. Sadashivamurthy та KM Lokanatha Rai. "Biological assay and antimitotic activity of novel analogues of β-apopicropodophyllin". Indian Journal of Pharmaceutical Sciences 69, № 1 (2007): 116. http://dx.doi.org/10.4103/0250-474x.32122.

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OUARZANE AMARA, MERYEM, JEAN-FRANCOIS FRANETICH, NICOLAS BOULADOUX, et al. "In vitro Activity of Antimitotic Compounds Against the Microsporidium Encephalitozoon intestinalis." Journal of Eukaryotic Microbiology 48 (June 2001): 99s—100s. http://dx.doi.org/10.1111/j.1550-7408.2001.tb00469.x.

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Verdier-Pinard, Pascal, John A. Kepler, George R. Pettit, and Ernest Hamel. "Sustained Intracellular Retention of Dolastatin 10 Causes Its Potent Antimitotic Activity." Molecular Pharmacology 57, no. 1 (2000): 180–87. https://doi.org/10.1016/s0026-895x(24)26456-7.

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45

Hadjeri, Mohamed, Eva-Laure Peiller, Chantal Beney, et al. "Antimitotic Activity of 5-Hydroxy-7-methoxy-2-phenyl-4-quinolones." Journal of Medicinal Chemistry 47, no. 20 (2004): 4964–70. http://dx.doi.org/10.1021/jm049876x.

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46

Rao, Pemmaraju N., James W. Cessac, James W. Boyd, Arthur D. Hanson, and Jamshed Shah. "Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs. Part III." Steroids 73, no. 2 (2008): 171–83. http://dx.doi.org/10.1016/j.steroids.2007.10.016.

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Rao, Pemmaraju N., James W. Cessac, James W. Boyd, Arthur D. Hanson, and Jamshed Shah. "Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs—Part II." Steroids 73, no. 2 (2008): 158–70. http://dx.doi.org/10.1016/j.steroids.2007.11.003.

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48

Liou, Jing-Ping, Jang-Yang Chang, Chun-Wei Chang, et al. "Synthesis and Structure−Activity Relationships of 3-Aminobenzophenones as Antimitotic Agents." Journal of Medicinal Chemistry 47, no. 11 (2004): 2897–905. http://dx.doi.org/10.1021/jm0305974.

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Vasilenko, Dmitry A., Elena B. Averina, Nikolay A. Zefirov, et al. "Synthesis and antimitotic activity of novel 5-aminoisoxazoles bearing alkoxyaryl moieties." Mendeleev Communications 27, no. 3 (2017): 228–30. http://dx.doi.org/10.1016/j.mencom.2017.05.003.

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50

Valls, Robert, Bernard Banaigs, Louis Piovetti, Albert Archavlis, and Jacques Artaud. "Linear diterpene with antimitotic activity from the brown alga Bifurcaria bifurcata." Phytochemistry 34, no. 6 (1993): 1585–88. http://dx.doi.org/10.1016/s0031-9422(00)90850-1.

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