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Дисертації з теми "Antineoplastic agents"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Wan, Jung Wing. "Novel ether lipids as antineoplastic agents." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242627.

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2

Molyneux, Gemma. "Studies on the haemotoxicity of antineoplastic agents." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435080.

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3

Chen, Alina. "New polyamine analogues as potential antineoplastic agents." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/2680.

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The naturally occurring polyamines play an essential role in cell growth and proliferation. The levels of polyamines have been shown to increase in rapidly proliferating cancer cells. Therefore, compounds that inhibit enzymes in polyamine biosynthetic pathway may have therapeutic potential. Compounds capable of providing both in vitro and in vivo inhibition of almost all enzymes in the polyamine biosynthetic pathway are known. An exception is the lack of an agent that inhibits spermidine/spermine N 1 -acetyltransferase (SSAT), the rate-limiting enzyme in the catabolism of polyamines. The desig

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4

Ganley, Brian. "Investigations into the chemical mechanisms of biological activity by heterocyclic di-N-oxides and 1,2 benzodithiolan-3-one 1-oxides." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999285.

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5

Ramirez, Daniel A. Kane Robert R. "Synthesis of protected amino thymidines and new thiol derivatives of the vascular targeting agent combretastatin A-4." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/5008.

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6

Ganley, Brian Christopher. "Investigations into the chemical mechanisms of biological activity by heterocyclic di-N-oxides and 1,2 benzodithiolan-3-one 1-oxides /." free to MU campus, to others for purchase, 2000. http://wwwlib.umi.com/cr/mo/fullcit?p9999285.

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7

Reese, Michael. "Drug design (STAT5 modulators), development (Glyceollin I) and improvement (Esmolol Plus) /." Connect to full text in OhioLINK ETD Center, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1265033116.

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Thesis (M.S.)--University of Toledo, 2009.<br>Typescript. "Submitted as partial fulfillment of the requirements for the Master of Science Degree in Medicinal Chemistry." "A thesis entitled"--at head of title. Bibliography: leaves 45-48.

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8

Kanyanda, Stonard Sofiel Elisa. "Screening of natural products and Alkylating agents for Antineoplastic Activity." Thesis, University of the Western Cape, 2007. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6433_1363357514.

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<p>Background and objectives: Apoptosis is a process in which a cell programmes its own death. It is a highly organized physiological mechanism in which injured or damaged cells are destroyed. Apart from physiological stimuli however, exogenous factors can induce apoptosis. Many anti-cancer drugs work by activating apoptosis in cancer cells. Natural substances have been found to have the ability to induce apoptosis in various tumour cells and these substances have been used as templates for the construction of&nbsp<br>novel lead compounds in anticancer treatment. On the other hand, alkylating

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9

Parker-, Johnson Kitani A. "An evaluation of novel antineoplastic agent on prostate cancer." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2003. http://digitalcommons.auctr.edu/dissertations/3074.

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This study examines the effects of novel antineoplastic agents(isochalcones) on human metastatic prostate cancer cell lines by screening cells for their relative antiproliferative effects, measuring the protein expression levels of specific oncogenes by Western blotting, and evaluating an array of genes ( 5184) to determine possible mechanisms of action of these novel isochalcones. The array data were supported by real-time polymerase chain reaction (PCR) techniques. The antineoplastic agents were screened in human metastatic prostate cancer cell lines (LNCaP, DU145, PC-3, and MDA-PCa-2b) and

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10

Lin, Tung Yin. "Synthetic studies towards the stellettins /." View online, 2008. http://repository.eiu.edu/theses/docs/32211131443971.pdf.

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11

Hendrix, Martin. "Synthetic approaches toward pancratistatin." Thesis, Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/27300.

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12

Tinkleman, Joseph M. Smith Forrest T. "Synthesis of 10, 11, 12, 12a, 12b, 13-hexahydro-5hbenzo[f]cyclopropa[d]pyrido[1,2-b] isoquinoline-5,7(9H)dione and related compounds." Auburn, Ala, 2009. http://hdl.handle.net/10415/1655.

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13

Lee, Seung-joo. "Molecular mechanism for DNA recognition by DNA alkylating antitumor agents /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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14

Younis, Islam Rasem. "In vitro elucidation of the metabolic fate of the anticancer drug busulfan." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5576.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xi, 109 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 92-109).

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15

Ekborn, Andreas. "Cisplatin induced ototoxicity : pharmacokinetics, prediction and prevention /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-721-5.

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16

Carroll, Brian J. "Studies on the biosynthesis of naturally occurring antitumor agents /." Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/11562.

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17

Reader, Michael. "Studies towards the synthesis of the macrolide portion of ulapualide A." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294255.

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18

Genovino, Julien. "Studies towards the total synthesis of (+)-spirastrellolide A." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608940.

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19

Law, Kin Bon. "Mechanistic study of type I ribosome-inactivating protein as anti-influenza and anti-tumour agent." HKBU Institutional Repository, 2000. http://repository.hkbu.edu.hk/etd_ra/253.

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20

Erdal, Hamdiye. "Characterization of the mechanisms of action of anticancer agents in vitro and monitoring their effects in vivo /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-202-0/.

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21

Flynn, Allison. "Transition metals as anti-tumoral agents : some structure-function relationships of the platinum group metals /." Master's thesis, This resource online, 1994. http://scholar.lib.vt.edu/theses/available/etd-03022010-020016/.

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22

Arthasery, Phyllis Pinney Kevin G. "Discovery and development of unique small molecule chromene based ligands and combretastatin analogs as potential second generation vascular disrupting agents towards cancer chemotherapy." Waco, Tex. : Baylor University, 2005. http://hdl.handle.net/2104/3020.

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23

Ellenberger, William Paul. "Synthesis of DEF ring synthons to nogarol anthracyclines /." Full text open access at:, 1987. http://content.ohsu.edu/u?/etd,136.

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24

Baghdanov, Vaceli M. "Synthetic studies of naturally occurring hydroxylated polycyclic compounds : daunomycinone and pillaromycinone /." Full text open access at:, 1987. http://content.ohsu.edu/u?/etd,142.

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25

Johansson, Magnus. "Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2696-4.

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26

Zhu, Chaoyong. "Deoxyribonucleoside kinases in nuclear and mitochondrial DNA precursor synthesis : phosphorylation of anti-cancer nucleoside analogs in different subcellular compartments /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4367-2/.

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27

Mancini, Michael. "Approaches to the synthesis of xanthone analogs of the anthracycline class of anticancer agents." Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=72059.

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Анотація:

Several strategies outlining approaches to the synthesis of the heteroanthracyclinones 4-demethoxyxanthodaunomycinone and 4-demethoxyisoxanthodaunomycinone (7,8,9,10-tetrahydrobenzo(b)-6,7,9,11-tetrahydroxy-9-acetylxanthen-12 and 5-one) are described.<br>The condensation of tetralin 2-acetyl-5,8-dimethoxy-1,2,3,4-tetrahydro-2-naphthol with o-methoxybenzoic acid was investigated and useful large-scale syntheses of important 1,4-dimethoxy-substituted xanthone intermediates were developed.<br>Diels-Alder cycloaddition reaction between a xanthone-derived o-quinodimethane intermediate and an olefin

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28

Williams, Elizabeth G. L. "Total synthesis of novel analogues and hybrids of the anti-cancer agents dictyostatin and discodermolide." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610776.

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29

Naylor, Guy James. "Studies of novel anticancer agents : progress towards leiodermatolide and the total synthesis of analogues and hybrids of dictyostatin, discodermolide and taxol." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609305.

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30

Rotella, David Paul. "The synthon concept in medicinal chemistry : synthesis and applications of cyclohexane diol diamines /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487263399027046.

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31

陳志強. "中醫藥抗腫瘤復發轉移文獻研究". HKBU Institutional Repository, 2012. http://repository.hkbu.edu.hk/etd_ra/1336.

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32

Neidigh, Kurt Alan. "Studies on the biosynthesis of podophyllotoxin : synthesis of labelled yatein and matairesinol, two potential precursors of podophyllotoxin /." This resource online, 1992. http://scholar.lib.vt.edu/theses/available/etd-09192009-040255/.

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33

Xie, Yanqi. "SEMISYNTHETIC AURONES: A FAMILY OF NEWLY DISCOVERED TUBULIN INHIBITORS AS ANTINEOPLASTIC AGENTS." UKnowledge, 2019. https://uknowledge.uky.edu/biochem_etds/44.

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Aurones belong to an uncommon class of plant flavonoids that provide the bright yellow coloration of some ornamental flowers and that possess a range of biological activities. Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic variants of the (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one scaffold that possessed low nanomolar in vitro potency in cell proliferation assays using various cancer cell lines, in vivo potency in prostate cancer PC-3 xenograft and zebrafish models, selectivity for the colchicine-binding site on tubulin, and absence of appreciab

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34

McCandless, Stewart Grant. "The synthesis of some novel 1,2,3-benzotriazine-platinum complexes with potential antineoplastic activity." Thesis, Heriot-Watt University, 1988. http://hdl.handle.net/10399/999.

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35

Saylor, Melissa Anne. "Isolation of plant-derived signal transduction inhibitors : potential antitumor agents." Thesis, Georgia Institute of Technology, 1992. http://hdl.handle.net/1853/30989.

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36

McPherson, John Peter. "DNA topoisomerase IIÃ, role in resistance to antineoplastic agents and induction of apoptosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0009/NQ35248.pdf.

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37

Jönsson, Videsäter Kerstin. "Expression of multidrug resistance genes and proteins and effect of selenite in anthracycline-resistant human tumor cell lines /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-889-0/.

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38

Doetsch, Natalie, Kimberly Harder-Ibarola, and Aliyah Sheth. "Exploration of Classic Confounders in Lymphoblastoid Cell Lines used to Study Select Antineoplastic Agents." The University of Arizona, 2010. http://hdl.handle.net/10150/623750.

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Class of 2012 Abstract<br>OBJECTIVES: Therapeutic response to chemotherapeutic agents in vitro can be studied using immortalized lymphoblastoid cell lines (LCLs). While LCLs provide a valuable model to study heritable factors and anticancer drug reponse in large populations, the results may be confounded by properties inherent to the model. This study is used to explore possible confounders in Choy et al.’s publicially available dataset (Accession#: GSE11582). METHODS: This study utilized Affymetrics U133A array gene expression and phenotypic data for 162 unrelated LCLs. SPSS was used for two

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39

Higginbotham, Mary Lynn. "Preclinical pharmacokinetic and tolerance assessment and phase I clinical trial of MU-gold, a novel chemotherapeutic agent /." Free to MU Campus, others may purchase, 2004. http://wwwlib.umi.com/cr/mo/fullcit?p1421141.

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40

Oosthuizen, Lukas Marthinus. "New platinum coordination compounds : their synthesis, characterization and anticancer application." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1018795.

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The aim of this thesis was to investigate the properties of novel platinum compounds with possible potential as anticancer agents, and to determine how their behaviour could lead to a better understanding of the chemistry involved. The final criteria were improvement of their anticancer behaviour. Since many questions are still unanswered as to the role of sulfur in anticancer action, studies were undertaken to synthesize novel platinum(II) complexes having non-leaving groups consisting of a combination of an aromatic nitrogen and thioetherial sulfur capable of forming a five membered ring upo

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41

Chu, Qingjun. "S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC), water soluble garlic derivatives, suppress growth and invasion of androgen-independent prostate cancer, under in vitro and in vivo conditions." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36749540.

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42

Gomes, Erica Manuela Tong Alex W. "Anti-tumor properties of CD40 ligand when delivered as a transgene by the conditional replicative oncolytic adenovirus AdEH to breast cancer cells." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4901.

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43

Lindemalm, Synnöve. "Pharmacokinetic studies on cladribine /." Stockholm : [Karolinska institutets bibl.], 2001. http://diss.kib.ki.se/2001/91-7349-043-1/.

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44

Martinsson, Petra 1974. "Pharmacological studies of CHS 828 and etoposide induced tumour cell death /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5157-8/.

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45

Nylén, Urban D. "Interactive antiproliferative mechanisms when 5-fluorouracil is combined with cisplatin or ionizing radiation : an in vivo and in vitro experimental study /." Stockholm, 2000. http://diss.kib.ki.se./2000/91-628-4480-6/.

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46

Howard, Edward William. "The potential clinical applications of garlic-derived S-allylmercaptocysteine in the treatment of hormone refractory prostate cancer." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38165156.

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47

Li, Hoi-yee. "Signaling pathways modulated by gold-1A in its anti-tumour effects against hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B38838849.

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48

Zhu, Yanting. "Exploring alternative cytotoxic strategies for cancer treatment." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/65.

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Triggering direct cytotoxicity has been the most common strategy for developing cancer treatments. The cytotoxic regimens currently used in the clinic mainly include radiation therapy, classic chemotherapeutic drugs (e.g. DNA damaging drugs and anti-mitotic drugs) and selected new targeted drugs. Although these therapies are the standard of care for most cancer patients, they suffer significant limitations: responses to these therapies vary significantly between cancer types and patients; sensitive cancers tend to acquire resistance; and they cause serious toxicity, particularly to dividing ce

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49

Xiao, Zhe. "Biosynthetic studies of tetrodotoxin and its anticancer activities assessment in vitro." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/56.

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In this study, the synthesis of TTX by three species of TTX-producing bacteria (Vibrio alginolyticus, Microbacterium arabinogalactanolyticum and Serratia marcescens) was conducted in a 10-L fermentor under the same controlled fermentation conditions for each of a period of 60 hours. The bacterial growth curves were monitored and the TTX synthesized in the culture medium was determined by HPLC. The TTX biosynthesis was found limited at the microgram level per L of culture medium with toxicities 14.7 MU (mouse unit) and 13.0 MU per mL in the partially purified culture medium of V. alginolyticus

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50

Fannon, Nanette Gayle 1962. "BOUVARDIN ANALOGS (DEOXYBOUVARDIN, IODINATION, IODODEOXYBOUVARDIN, O-METHYL-N-BOC-L-TYROSINE, ANTITUMOR AGENTS)." Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/291590.

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