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Статті в журналах з теми "Antitoxic effect"

Автор: Grafiati

Опубліковано: 7 червня 2025

Оновлено: 2 серпня 2025

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1

Picardeau, Mathieu, Shuangxi Ren, and Isabelle Saint Girons. "Killing Effect and Antitoxic Activity of theLeptospira interrogans Toxin-Antitoxin System inEscherichia coli." Journal of Bacteriology 183, no. 21 (2001): 6494–97. http://dx.doi.org/10.1128/jb.183.21.6494-6497.2001.

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ABSTRACT We report the first evidence of a chromosome-encoded toxin-antitoxin locus in spirochetes. This locus has been found in the pathogenic spirochete Leptospira interrogans and exhibits homologies with the pem/chploci. The L. interrogans chp locus consists of two genes: chpK (for “killer protein”) and its upstream partner chpI (for “inhibitory protein”). Expression of ChpK in Escherichia coli results in the inhibition of bacterial growth. The coexpression of ChpI neutralizes ChpK toxicity. By Southern blot analysis, chp homologs were found in all representative pathogenic strains of L. in

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2

Frolov, A. V., G. I. Rakhmatullina, V. A. Guryanova, E. N. Mayorova, and R. A. Volkov. "ASSESSMENT OF ANTITOXIC AND ANTI-INFECTIOUS ACTIONS OF THE EXPERIMENTAL PREPARATION." Scientific Notes Kazan Bauman State Academy of Veterinary Medicine 248, no. 4 (2021): 246–49. http://dx.doi.org/10.31588/2413-4201-1883-248-4-246-249.

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In the course of the research, the antitoxic and anti-infectious effects of the developed drug were determined on white mice and white rats. To assess the antitoxic effect in the experiment on white rats, cadmium damage was modeled, followed by taking into account the antidote activity. An increase in the survival rate of animals receiving the drug was found – 60 % versus 40 % in the control, higher hematological indicators: the content of hemoglobin, erythrocytes and leukocytes in the blood of experimental animals was higher than similar control values, respectively, by 3.8, 15.3 and 16,4 %.

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3

Kaipainen, W. J. "ON THE ANTITOXIC EFFECT OF VITAMIN B12." Acta Pathologica Microbiologica Scandinavica 55, no. 1 (2009): 35–38. http://dx.doi.org/10.1111/j.1699-0463.1962.tb04096.x.

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4

A., V. "Normal equine serum for staphylomycosis." Kazan medical journal 22, no. 8 (2021): 960. http://dx.doi.org/10.17816/kazmj78445.

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Studying the effect of normal horse serum in vivo and in vitro on staphylococci, Benedek (Zeit. F. 1mm. U. Exper. Ther., B. 47, H. 2) found that it has antitoxic, bactericidal and tissue immunizing effects.

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5

Nikolaevsky, V. A., D. M. Martirosyan, E. N. Muzalevskaya, L. A. Miroshnichenko, and V. I. Zoloedov. "Hepatotropic, antioxidant and antitoxic action of amaranth oil." Functional Foods in Health and Disease 4, no. 5 (2014): 159. http://dx.doi.org/10.31989/ffhd.v4i5.18.

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Background: It is our opinion that amaranth seed oil’s properties merit further study due to their high quantity of squalene. Squalene has been shown to have antitoxic, antioxidant, and hepatotropic properties. The liver is one of the most important organs in the human body, and as a filtering organ, it is subjected to many toxic compounds and free radicals. Thus, protecting the liver with an antioxidant and antitoxic compound could offer significant benefits.Objective: In the present study we have evaluated the antitoxic, antioxidant, and hepatotropic (hepatoprotective) effects of amaranth oi

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6

Syrov, V., L. Pulatova, and O. Kamalov. "INCREASING THE ADAPTATION POTENTIAL OF THE ORGANISM BASED ON THE ANTITOXIC EFFECT OF EXUMIDE." Scientific heritage, no. 160 (May 8, 2025): 12–17. https://doi.org/10.5281/zenodo.15362501.

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The paper studies the issues of practical application of exumid, which is a total extractive preparation containing a sum of phytoecdysteroids and iridoid glycosides isolated from an endemic plant of Uzbekistan. The increase in the antitoxic capabilities of the animal organism under the influence of exumid was also quite clearly revealed in the tissue hypoxia model. It was shown that in all the experiments conducted, Exumid exhibited a more pronounced positive effect than a well-known herbal medicinal product – liquid Eleutherococcus extract.

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7

Geller, L. I., L. N. Gladkikh, and M. V. Gryaznova. "Therapy of diabetics with fatty hepatosis." Problems of Endocrinology 39, no. 5 (1993): 20–22. http://dx.doi.org/10.14341/probl11935.

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A ten-day course of karsil (silimarin, legalon) or silibor therapy improved the absorption (as indicated by ueviridin test) and oxidative-antitoxic (as shown by antipyrin test) hepatocyte functions in patients with non-insulin-dependent diabetes mellitus with hepatosis. A similar ten-day course of Liv-52 did not change the studied liver parameters. lnductothermal exposure of the splenic area (a 20 min session daily for 5 days) improved the absorption and antitoxic functions of the liver in diabetics. A positive effect of splenic inductothermia persisted for at least two weeks. The peak values

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8

Shabunin, Sergey, Vasilina Gritsyuk, Galina Vostroilova, Dmitriy Shabanov, Nina Khokhlova, and Anastasiya Korchagina. "Study of Mutagenic and Antitoxic Properties of Gentabiferon-B." Macedonian Veterinary Review 45, no. 1 (2022): 79–87. http://dx.doi.org/10.2478/macvetrev-2022-0016.

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Abstract The combination of immunomodulators and antibiotics in the treatment of animals with diseases of bacterial etiology is one of the effective strategies for animal therapy. The drug gentabiferon-B combines antibiotic gentamicin and species-specific (bovine) recombinant interferons -α and -γ. The study aimed to evaluate the effect of course application of gentabiferon-B on the cytogenetic stability of bone marrow cells of outbred mice after administering mitomycin C (MMC). The proportion of polychromatophilic erythrocytes in the bone marrow was assessed. There was no effect of gentabifer

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9

Sharma, Sukriti, Jaram Singh, Dr Kulwinder Kaur, and Sanjeev Kumar. "Use of Agada Preparation in the Current Scenario- A Review Article." International Research Journal of Ayurveda & Yoga 05, no. 10 (2022): 138–43. http://dx.doi.org/10.47223/irjay.2022.51023.

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Background: In current scenario, maximum diseases are caused due to idiosyncratic etiology. Agada Tantra is one of the eight branches of Ayurveda which focusses on Viruddhaahara (Incompatible food), Gara Visha (Concocted poison) and Dushivisha (Denatured/Latent Poison), conditions and their treatments. There are different types of Agada yogas that are mentioned in the Vishachikitsa granthas which possess antitoxin properties, antioxidant activities can be very useful in such disease condition. In today’s era we need complete Nirvishikarana (Detoxification) because many of the diseases are caus

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10

Burlacu, Anca Irina, and Cornelia Prisacaru. "Evaluation of the antitoxic effect of some phthalides containing vegetal products." Toxicology Letters 180 (October 2008): S62. http://dx.doi.org/10.1016/j.toxlet.2008.06.547.

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11

Vostroilova, G. A., V. A. Gritsyuk, D. I. Shabanov, A. A. Korchagina, and N. A. Khokhlova. "EVALUATION OF THE MUTAGENIC EFFECT OF THE DRUG SUBMASTIN-KRS." Transactions of the educational establishment “Vitebsk the Order of “the Badge of Honor” State Academy of Veterinary Medicine 58, no. 4 (2022): 12–17. http://dx.doi.org/10.52368/2078-0109-2022-58-4-12-17.

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In this research, we studied the potential mutagenic and toxic effects of the drug Submastin-KRS, which contains a mixture of species-specific bovine recombinant cytokines and vitamin A as active ingredients, on the body of white laboratory outbred mice (n=48). The animals were divided into 8 groups, 6 individuals in each one. A single injection of Submastin-KRS at a therapeutic and high dose (1/10 of LD50) did not lead to a statistically significant increase in the frequency of polymorphonuclear erythrocytes (PCE) with micronuclei and a decrease in the proportion of PCE in the bone marrow of

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12

GISMONDI, E., C. COSSU-LEGUILLE, and J. N. BEISEL. "Does the acanthocephalan parasite Polymorphus minutus modify the energy reserves and antitoxic defences of its intermediate host Gammarus roeseli?" Parasitology 139, no. 8 (2012): 1054–61. http://dx.doi.org/10.1017/s0031182012000315.

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SUMMARYIn disturbed environments, infected organisms have to face both parasitic and chemical stresses. Although this situation is common, few studies have been devoted to the effects of infection on hosts' energy reserves and antitoxic defence capacities, while parasite survival depends on host survival. In this study, we tested the consequences of an infection by Polymorphus minutus on the energy reserves (protein, lipid and glycogen) and antioxidant defence capacities (reduced glutathione, γ-glutamylcysteine ligase activity) of Gammarus roeseli males and females, in the absence of chemical

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13

Haddad, A. El Rabey. "The antitoxic, anticancer and antioxidant activity of thymoquinone derived from Nigella sativa L." International Journal of Biosciences (IJB) 25, no. 1 (2024): 179–87. https://doi.org/10.12692/ijb/25.1.179-187.

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Recent research aims to find out natural herbal remedies for treating various diseases resulted from oxidative stress, environmental toxins and pollutants, especially due to the insufficient number of anti-toxin drugs. The currently available antitoxins are multivitamins, glutathione, and N-acetyl cysteine. No known antitoxins for treating the advanced stages of endotoxemia, bacterial septicemia associated with septicemia, or septic shock. Recent studies focused on natural products as antioxidants that have strong anti-toxic effects by counteracting the effect of oxidants and show great potent

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14

Kuzminova, E. V., E. P. Dolgov, M. P. Semenenko, and P. V. Miroshnichenko. "Efficacy of a complex plant-based preparation for poultry mycotoxicosis." Veterinary Science Today, no. 4 (January 13, 2021): 272–76. http://dx.doi.org/10.29326/2304-196x-2020-4-35-272-276.

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The article presents results of efficacy studies for a complex plant-based preparation for poultry mycotoxicosis. Feed additive fibralin contains polysaccharides (dried sugar beet pulp) and phospholipids (rapeseed lecithin) in the proportion 4:1. Eighteen-day-old “Ross-308” broiler chickens with average weight of (665.10 ± 4.28) g were tested, since such mycotoxins as T-2 toxin, zearalenone and aflatoxin B1 were detected in their feeds. Maximum admissible level of each toxin was not exceeded, however, their cumulative effect on poultry resulted in mycotoxicosis. Use of fibralin in the feed (3

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15

Dragunsky, Evgenia M., Evelyn Rivera, Wendy Aaronson, et al. "Experimental evaluation of antitoxic protective effect of new cholera vaccines in mice." Vaccine 10, no. 11 (1992): 735–36. http://dx.doi.org/10.1016/0264-410x(92)90505-e.

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16

Prokhoda, Irina, Elena Eliseeva, Elena Stratienko, Nataliya Katunina, and Nadezhda Peshkova. "Prospects for processing bee bread as a natural adaptogen." BIO Web of Conferences 160 (2025): 02014. https://doi.org/10.1051/bioconf/202516002014.

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In the work were studied complex lipids, amino and fatty acid composition of flower pollen (pollen) and bee bread and were scientifically substantiated it`s adaptogenic and antitoxic effects on a living organism. The results of the research showed that all the studied pollen samples collected in the Bryansk region contain high amounts of glutamic and aspartic amino acids; among the fatty acids are linoleic and palmitic. The quantitative composition of amino and fatty acids of canned dried parchment does not significantly change during storage for 1 year. The adaptogenic effect of bee bread is

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17

Gainullin, Ruslan, Edie Plotnikova, Mulanur Shakurov, et al. "The effect of immunotherapy on the state of the antioxidant system in radiation damage in rats." E3S Web of Conferences 431 (2023): 01001. http://dx.doi.org/10.1051/e3sconf/202343101001.

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Immunotropic drugs (such as sera, blood plasma and immunoglobulins) have polyfunctional activity with anti-infectious, antitoxic, homeostasis-regulating properties. Based on this, we conducted the present study with the purpose to evaluate the therapeutic effect of anti-cadmium -anti-radiation serum (AARS) on the level of radiation-chemical damage. Modeling of experimental radiation-chemical damage was carried out by preliminary 4-time subcutaneous injection of cadmium chloride solution (CdCl2) at doses of 1/500 LD50, followed by radiation exposure of 90 outbred white rats at doses of 7.0 and

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18

Khisamova, A., та O. Gizinger. "The antitoxic and protective effects of Curcuma longa and it`s active agent, Curcumin: оverview". Terapevt (General Physician), № 6 (1 червня 2020): 66–72. http://dx.doi.org/10.33920/med-12-2006-09.

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In the modern world, where a person is exposed to daily stress, increased physical exertion, the toxic effect of various substances, including drugs. The task of modern science is to find antioxidants for the body. These can be additives obtained both synthetically and the active substances that we get daily from food. Such a striking example is turmeric, obtained from the plant Curcuma longa. Recently, it has been known that curcumin has an antioxidant, anti-inflammatory, anti-cancer effect and, thanks to these effects, plays an important role in the prevention and treatment of various diseas

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19

Jahan, M. S., M. S. Islam, M. Gautam, and M. E. R. Bhuiyan. "Lead acetate induced toxicities and antitoxic effect of Vitamin E and selenium in mice." Bangladesh Journal of Veterinary Medicine 19, no. 1 (2021): 73–83. http://dx.doi.org/10.33109/bjvmjj2021lam1.

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Background: The experiment was conducted to evaluate the effect of different dosages of lead in the hematological parameters of mice and to observe the antitoxic role of Vitamin E and Selenium in induced lead toxicities. Moreover, the toxic effect of lead in the reproduction of female mice was also examined. Methods: A total of 72 (48 male and 24 female) Swiss albino mice were used in the experiment. After adaptation, 42 male mice were selected for hematological studies and divided into seven groups (n=6) where Group A represented healthy control mice and Group B, C, and D were treated with le

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20

Gritsenko, Alexander Vladimirovich, Konstantin Vyacheslavovich Glemba, Alexander Sergeevich Menshenin, and Stepan Andreevich Chokoy. "Environmental aspects in operation of a gasoline car with antitoxic system." Transport of the Urals, no. 3 (2023): 91–98. http://dx.doi.org/10.20291/1815-9400-2023-3-91-98.

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In the Russian Federation, unlike the European countries, where the Euro-6 standard is in effect and introduction of Euro-7 is expected until 2025, the Euro-5 standard has been adopted and the possibility of introducing Euro-6 is only being formed, but the production and technical infrastructure of the service is not ready for this. The article defines the main parameters characterizing the qualitative and quantitative difference of the fuel-air mixture and their effect on the output parameters of exhaust gas toxicity, examines in detail the areas of change in toxicity parameters when varying

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21

BULGAKOVA, V. A. "THE PRACTICE OF CLINICAL USE OF AZOXIMER BROMIDE FOR THERAPY AND PREVENTION OF RESPIRATORY INFECTIONS." Russian Journal of Allergy 11, no. 3 (2014): 73–81. http://dx.doi.org/10.36691/rja538.

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The review presents the results of various studying of basic properties of azoximeri bromidum (polyoxidonium). The experience of application of immunomodulator in patients with respiratory diseases was analyzed. polyoxidonium has expressed immunomodulatory activity (including interferonproducing), has nonspecific protective effect against a broad range of pathogens that are not based on direct inhibition of microorganisms, and on the regulation of immune function. in addition, the drug has antitoxic and antioxidant properties. in the acute period of the disease polyoxidonium is recommended to

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22

Besednova, N. N., T. S. Zaporozhets, B. G. Andryukov, et al. "Hemorrhagic Fevers: Antiviral Effects and Molecular Targets of Biologically Active Polysaccharides and Lectins from Marine Aquatic Organisms." Antibiotics and Chemotherapy 67, no. 3-4 (2022): 53–69. http://dx.doi.org/10.37489/0235-2990-2022-67-3-4-53-69.

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The search and creation of etiotropic drugs is one of the most important tasks of modern virology. This review examines the antiviral influence of certain natural substances (sulfated polysaccharides and lectins from marine hydrobionts) on the causative agents of hemorrhagic fevers. Such compounds can be used as an alternative to synthetic drugs due to their low toxicity, rare side effects, and the absence of virus resistance. In addition to a strong antiviral effect, polysaccharides and lectins possess anti-inflammatory, immunomodulatory, antioxidant, and antitoxic properties, which are impor

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23

Besednova, N. N., T. S. Zaporozhets, B. G. Andryukov, et al. "Hemorrhagic Fevers: Antiviral Effects and Molecular Targets of Biologically Active Polysaccharides and Lectins from Marine Aquatic Organisms." Antibiotics and Chemotherapy 67, no. 3-4 (2022): 53–69. http://dx.doi.org/10.37489/0235-2990-2022-67-3-4-53-69.

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Анотація:

The search and creation of etiotropic drugs is one of the most important tasks of modern virology. This review examines the antiviral influence of certain natural substances (sulfated polysaccharides and lectins from marine hydrobionts) on the causative agents of hemorrhagic fevers. Such compounds can be used as an alternative to synthetic drugs due to their low toxicity, rare side effects, and the absence of virus resistance. In addition to a strong antiviral effect, polysaccharides and lectins possess anti-inflammatory, immunomodulatory, antioxidant, and antitoxic properties, which are impor

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24

Guidetti, Gianandrea, Alessandro Di Cerbo, Angela Giovazzino, et al. "In VitroEffects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity." Journal of Immunology Research 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/5457010.

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Several extrinsic factors, like drugs and chemicals, can foster autoimmunity. Tetracyclines, in particular oxytetracycline (OTC), appear to correlate with the emergence of immune-mediated diseases. Accumulation of OTC, the elective drug for gastrointestinal and respiratory infectious disease treatment in broiler chickens, was reported in chicken edible tissues and could represent a potential risk for pets and humans that could assume this antibiotic as residue in meat or in meat-derived byproducts. We investigated thein vitroanti-inflammatory properties of a pool of thirteen botanicals as a pa

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25

Xian Ju, Huang, Zhou Huan, Jiang Yi, Zheng Mi, and Huang Xian Ju. "Antitoxic effect of baicalin and glycyrrhetic acid on PC12 cells induced by Aconitum brachypodum Diel." African Journal of Pharmacy and Pharmacology 9, no. 12 (2015): 424–32. http://dx.doi.org/10.5897/ajpp2014.4210.

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26

Lupanova, I. A., O. L. Saybel, E. N. Kurmanova, E. V. Ferubko, I. A. Martynchik, and P. G. Mizina. "Antitoxic Effects of Chicory Herb Extract Fractions in Rats with Toxic Hepatitis." Russian Journal of Gastroenterology, Hepatology, Coloproctology 32, no. 2 (2022): 55–62. http://dx.doi.org/10.22416/1382-4376-2022-32-2-55-62.

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Aim. To evaluate the antitoxic activity of chicory herb extract fractions in rats with toxic hepatitis.Materials and methods. There were 64 male rats were divided into groups of 6 animals that received the whole chicory herb extract, its fractions, or the reference drug (RD) and 2 groups did not receive any drug. The Silimar substance (a dry purified extract obtained from the fruits of milk thistle [Silybum marianum]) was chosen as RD. Animals from one of the groups that did not receive the drug (control group) and the groups that received drugs were injected with CCl4 to simulate toxic liver

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27

Semenenko, Marina, Olga Lanets, Andrey Abramov, Elena Kuzminova, and Inna Zholobova. "Research of the detoxification properties of the preparation phytoglinol on the heat stress model." E3S Web of Conferences 210 (2020): 06001. http://dx.doi.org/10.1051/e3sconf/202021006001.

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The article discusses the possibility of using a new veterinary preparation phytoglinol to improve the quality of meat and dairy raw materials in the context of solving the problems of food security in the Russian Federation. An experiment conducted on laboratory animals to simulate heat stress revealed pronounced detoxification and stress-correcting properties of the preparation. The obtained results indicate that the new preparation phytoglinol not only ensures the correction of metabolic homeostasis under heat stress conditions, but also helps to weaken endotoxicosis, reduce the level of li

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28

Mateo-Fernández, Marcos, Tania Merinas-Amo, Miguel Moreno-Millán, Ángeles Alonso-Moraga, and Sebastián Demyda-Peyrás. "In VivoandIn VitroGenotoxic and Epigenetic Effects of Two Types of Cola Beverages and Caffeine: A Multiassay Approach." BioMed Research International 2016 (2016): 1–15. http://dx.doi.org/10.1155/2016/7574843.

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The aim of this work was to assess the biological and food safety of two different beverages: Classic Coca Cola™(CCC) and Caffeine-Free Coca Cola (CFCC). To this end, we determined the genotoxicological and biological effects of different doses of lyophilised CCC and CFCC and Caffeine (CAF), the main distinctive constituent. Their toxic/antitoxic, genotoxic/antigenotoxic, and chronic toxicity (lifespan assay) effects were determinedin vivousing theDrosophilamodel. Their cytotoxic activities were determined using the HL-60in vitrocancer model. In addition, clastogenic DNA toxicity was measured

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29

Kokorev, O. V., V. N. Hodorenko, G. Ts Dambaev, and V. E. Gunther. "Evaluation of Porous TiNi-based Alloy as a Scaffold for Liver Tissue Engineering." KnE Materials Science 2, no. 1 (2017): 140. http://dx.doi.org/10.18502/kms.v2i1.790.

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Complex analysis of development of cells of liver – hepatocytes in the biocompatible scaffold, fabricated of porous-permeable TiNi-based alloy has been performed. Specific stages of development of cellular population in pores of scaffold are displayed in the present investigation. The stepwise characteristic of developing of hepatocytes in porous-permeable structure from TiNi-based alloy is demonstrated. Nanoporous surface of pores in incubator permit cells to be reliably fixed and produce growth to cellular colonies, and porous-permeable structure of scaffold allows penetrating to nutrients f

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30

Gerush, Oleg, Olena Lenytska, Larysa Yakovleva, Liudmyla Gladkova, and Igor Gerush. "Investigation of the hepatoprotective properties of “Phytovenol” capsules on the model of medicamentous hepatitis in rats." Current Issues in Pharmacy and Medical Sciences 27, no. 4 (2014): 240–42. http://dx.doi.org/10.1515/cipms-2015-0024.

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Abstract This scientific paper is an investigation of the pharmacological activity of the new medical preparation “Phytovenol” (capsules in the dose of 150 mg/kg) on the pattern of hepatitis in rats induced by paracetamol administration. The authors of the article, for the first time under experimental conditions, detected a hepatoprotective effect that was brought about by “Phytovenol” capsule administration. This is realized due to the antioxidant, antitoxic and anticytolytic activity of the examined medicine. The study found that its efficacy is not lower than the classical hepatoprotector

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31

Bzducha-Wróbel, Anna, Monika Janowicz, Marcin Bryła, and Iga Grzesiuk. "Adsorption of Zearalenone by Aureobasidium pullulans Autolyzed Biomass Preparation and Its Detoxification Properties in Cultures of Saccharomyces cerevisiae Yeast." Toxins 16, no. 2 (2024): 105. http://dx.doi.org/10.3390/toxins16020105.

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Different preventive strategies are needed to minimize the intake risks of mycotoxins, including zearalenone (ZEN). The aim of this study was to determine the ZEN adsorption ability of an autolyzed biomass preparation of polymorphic yeast Aureobasidium pullulans A.p.-3. The evaluation of the antitoxic properties of the preparation was also performed in relation to Saccharomyces cerevisiae yeast (ATCC 2366, ATCC 7090 and ATCC 9763) used as a model cell exposed to a toxic ZEN dose. The preparation at a dose of 5 mg/mL showed the adsorption of ZEN present in model systems at concentrations betwee

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32

Tyurin, Vladimir G., Nina N. Potemkina, Anton Yu Sakharov, Vladimir G. Semenov, and Pavel N. Vinogradov. "TOXICOLOGICAL ASSESSMENT OF THE POLYMER MATERIAL «PENOPLEX» USED IN ANIMAL HUSBANDRY." Problems of veterinary sanitation, hygiene and ecology 3, no. 43 (2022): 355–60. http://dx.doi.org/10.36871/vet.san.hyg.ecol.202203011.

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The article presents the results of toxicological assessment of the polymer material «Penoplex». The above material is made of expanded polystyrene and is used in many areas of production, including to reduce heat loss of livestock facilities. Hematological studies of experimental and control animals revealed no differences in clinical parameters of the blood of white rats, the serum content of total protein, immunoglobulins and sulfhydryl groups. The polymer material «Penoplex » does not have a negative effect on the indicators that characterize the immunity of animals and the antitoxic funct

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33

Dmytriiev, Dmytro, Oleksandr Nazarchuk, and Yuliana Babina. "High-dose N-acetylcysteine therapy in the treatment of pneumonia." Perioperaciina Medicina 4, no. 1 (2021): 4–10. http://dx.doi.org/10.31636/prmd.v4i1.1.

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The article presents modern data on the use of N-acetylcysteine in the treatment of infectious diseases of the respiratory tract in the practice of a physician. Its antioxidant, mucolytic, anti-inflammatory, pulmoprotective and antitoxic properties are described. The emphasis is placed on the antioxidant properties of N-acetylcysteine, which are expressed when used in high doses of 1200 mg/day or more. There is a review of the literature on the use of high doses of N-acetylcysteine in the treatment of pneumonia, cystic fibrosis, COPD, ARDS. The effect of N-acetylcysteine on individual risk fac

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34

Pooja Shivaji Jauk, Shekhar Sahebrao Pandav, and Gajanan Suryabhan Sanap. "Tinospora cordifolia as medicinal herb." World Journal of Biology Pharmacy and Health Sciences 16, no. 3 (2023): 213–19. http://dx.doi.org/10.30574/wjbphs.2023.16.3.0508.

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Tinospora cordifolia is a popular medicinal plant which is used in several traditional drugs to cure several conditions. The common names are Amrita and Guduchi and belong to family Menispermaceae.. It is considered an essential herbal plant of Indian system of drug(ISM) and has been used in the treatment of fever, urinary problem, dysentery, skin conditions leprosy, diabetes, and numerous further conditions. The plant reported containing chemical constituents including Alkaloids, Terpenoids, Lignans, Steroids and others that establish the photochemistry and pharmacological exertion of Tinospo

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35

Shao, J., H. Shen, and B. Havsteen. "Purification, characterization and binding interactions of the Chinese-cobra (Naja naja atra) serum antitoxic protein CSAP." Biochemical Journal 293, no. 2 (1993): 559–66. http://dx.doi.org/10.1042/bj2930559.

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The characterization of the single-chain protein in Chinese-cobra (Naja naja atra) blood serum, which yields strong specific protection against the venom of the same snake, is reported. The protein, CSAP (cobra serum antitoxic protein), was purified to electrophoretic homogeneity. Over the pH range 5-9 it formed stable complexes with the neuro- and the cardio-toxin of the snake. The molecular size of the CSAP was estimated to be 70.3 +/- 0.3 kDa. Tryptic hydrolysis of CSAP yielded several peptides that were able to bind to the toxin. The native CSAP maximally bound 8 +/- 1 toxin molecules/mole

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36

Pooja, Shivaji Jauk, Sahebrao Pandav Shekhar, and Suryabhan Sanap Gajanan. "Tinospora cordifolia as medicinal herb." World Journal of Biology Pharmacy and Health Sciences 16, no. 3 (2023): 213–19. https://doi.org/10.5281/zenodo.11244068.

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Анотація:

<em>Tinospora cordifolia</em> is a popular medicinal plant which is used in several traditional drugs to cure several conditions. The common names are Amrita and Guduchi and belong to family Menispermaceae.. It is considered an essential herbal plant of Indian system of drug(ISM) and has been used in the treatment of fever, urinary problem, dysentery, skin conditions leprosy, diabetes, and numerous further conditions. The plant reported containing chemical constituents including Alkaloids, Terpenoids, Lignans, Steroids and others that establish the photochemistry and pharmacological exert

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37

R. Abdel Ghaffar, Faten, Heba M. Abd El latif, Mona S. Gouida, Ibrahim A. El-Elaimy, and Hany M. Ibrahim. "Evaluation of the Antitoxic Effect of Levamisole or Taurine Against High Dose of Cyclophosphamide in Tumor-Bearing Mice." Archives of Oncology and Cancer Therapy 2, no. 1 (2019): 16–29. http://dx.doi.org/10.22259/2638-5074.0201002.

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38

Guljaev, D. K., G. A. Terehin, D. O. Semakin, and V. D. Belonogova. "Antitoxic activity of spruce cone extract in acute lead acetate poisoning in experiment." Ural Medical Journal 22, no. 6 (2023): 43–49. http://dx.doi.org/10.52420/2071-5943-2023-22-6-43-49.

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Introduction. Lead contamination is continuing worldwide. The development of new effective drugs for lead poisoning is an urgent task. The aim of the work is to evaluate the effectiveness of dry aqueous extract of spruce cones in lead poisoning. Materials and methods. The experiment was carried out on 24 white mongrel rats of both sexes. Animals of the studied groups were administered aqueous solution of lead acetate. The animals of the third group were treated with the extract of cones of common spruce (extract) by intragastric administration 3 times a week for a month. Animals of the fourth

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39

Meshchaninov, Viktor, Denis Shcherbakov, Ekaterina Zvezdina, and Ilia Gavrilov. "Use of dry carbonic acid gas baths to correct human biological age." BIO Web of Conferences 22 (2020): 01012. http://dx.doi.org/10.1051/bioconf/20202201012.

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Relevance. The physiotherapy method of dry carbonic acid gas baths (DCAGB) mediated through the effects of carbon dioxide (CO2) is a minimally invasive treatment and prevention method of many human diseases. However, the CO2 effect on the rate of human aging has not been sufficiently studied. Therefore, it is relevant to study the effect of dry carbonic acid gas baths (DCAGB) physiotherapy method on peripheral blood indicators and biological age. Purpose. To assess the effect of carbon dioxide in dry carbonic acid gas baths condition on peripheral blood indicators and biological age in patient

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40

Ripert, Gabrielle, Silvia M. Racedo, Anne-Marie Elie, Claudine Jacquot, Philippe Bressollier, and Maria C. Urdaci. "Secreted Compounds of the Probiotic Bacillus clausii Strain O/C Inhibit the Cytotoxic Effects Induced by Clostridium difficile and Bacillus cereus Toxins." Antimicrobial Agents and Chemotherapy 60, no. 6 (2016): 3445–54. http://dx.doi.org/10.1128/aac.02815-15.

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Although the use of probiotics based onBacillusstrains to fight off intestinal pathogens and antibiotic-associated diarrhea is widespread, the mechanisms involved in producing their beneficial effects remain unclear. Here, we studied the ability of compounds secreted by the probioticBacillus clausiistrain O/C to counteract the cytotoxic effects induced by toxins of two pathogens,Clostridium difficileandBacillus cereus, by evaluating eukaryotic cell viability and expression of selected genes. Coincubation ofC. difficileandB. cereustoxic culture supernatants with theB. clausiisupernatant complet

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41

Pavlova, Natalia S., Galina I. Pavlenko, Dmitry A. Drozdov, Natalya A. Brichko, and Vasily I. Dorozhkin. "THE EFFECT OF METHYLSULFONYLMETHANE ON THE PHYSIOLOGICAL PARAMETERS OF WHITE RATS WITH EXPERIMENTAL CADMIUM AND LEAD INTOXICATION." Problems of veterinary sanitation, hygiene and ecology 1, no. 49 (2024): 143–51. http://dx.doi.org/10.36871/vet.san.hyg.ecol.202401021.

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Cadmium and lead, being one of the most dangerous ecotoxicants, are entering feed in an increasing number of regions and then into livestock products, posing a danger to the body of animals and humans. Therefore, the problem of reducing the toxic effect and accumulation of cadmium and lead in the body does not lose its relevance. One of the ways to reduce the accumulation and negative effects of heavy metals (HM) is the use of biologically active substances. Since one of the mechanisms of the toxic effect of heavy metals is the binding of sulfhydry groups, sulfur and preparations containing it

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42

Chandra kamal, Gopendra, and Nihchal Gupta. "A Review on concept of Vishaghna dravya (anti-toxic drugs) in ayurveda." Healer 2, no. 1 (2021): 95–99. http://dx.doi.org/10.51649/healer.44.

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ABSTRACT Introduction: Poison (visha) are of plant, animal and mineral origin which produce deleterious effect to the body. Agada Tantra is the branch of Ayurveda. There is requirement of antidotes and antitoxic drugs to arrest the effect of visha. There are such drugs called vishaghna (antipoisonous/ anti-toxic) mentioned in ayurveda samhitas and textbooks. Materials and Methods: major Ayurveda samhitas viz. Charak samhita, Sushruta samhita, Astang Hridyum were looked into for references regarding vishaghna drugs. Observation and results: there are huge number of plants, animal products

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43

Volodina, Svetlana Olegovna, Vladimir Vital'yevich Volodin, Elena Vladimirovna Nekrasova, Vladimir Nikolayevich Syrov, and Zainab Abdurakhmanovna Khushbaktova. "STRESS-PROTECTIVE EFFECT OF AQUEOUS INFUSION OF FERMENTED LEAVES CHAMAENERION AN-GUSTIFOLIUM (L.) SCOP." chemistry of plant raw material, no. 4 (December 21, 2020): 267–72. http://dx.doi.org/10.14258/jcprm.2020047677.

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The stress-protective effect of an aqueous infusion of fermented leaves of flowering plants of Сhamaenerion angustifolium (L.) Scop., (Onagraceae) collected in the middle taiga zone of the European North-East of Russia (near Syktyvkar), in experiments on white laboratory mice under acute stress has been studied. As a model of acute stress, the hanging of animals by the neck fold for 19 hours was used. Water infusion (1 : 20) was administered to each animal 0.5 and 1.0 ml for five days per os. It was found that the prophylactic administration of water infusion of fermented leaves in doses of 0.

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44

Gubergrits, N. B., N. V. Byelyayeva, A. Ye Klochkov, G. M. Lukashevich, and P. G. Fomenko. "Drug-induced liver injury: from pathogenesis to treatment." Herald of Pancreatic Club 46, no. 1 (2020): 72–80. http://dx.doi.org/10.33149/vkp.2020.01.10.

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The article presents data on classification, pathogenesis, clinical picture, diagnosis and differentiated treatment tactics, as well as practical algorithm for recognizing and preventing the development of drug-induced liver injury. Pathogenesis of drug-induced liver injury is analyzed, mechanisms of drug metabolism are explained, metabolism phases are described. Four main mechanisms of the pathological effect of drugs on the liver are identified: direct toxic effect on hepatocytes; toxic effect of drug metabolites; immunoallergic liver injury; idiosyncrasy. Peculiar attention is paid to the p

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45

Badr, Ahmed Noah, Karolina Gromadzka, Mohamed Gamal Shehata, Kinga Stuper-Szablewska, Kinga Drzewiecka, and Adel Gabr Abdel-Razek. "Prospective antimycotoxigenic action of wild Opuntia ficus-indica by-products." Czech Journal of Food Sciences 38, No. 5 (2020): 308–14. http://dx.doi.org/10.17221/11/2020-cjfs.

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Numerous natural compounds perform pharmaceutical, antimycotic and antitoxic purposes in the body system. The aim was to evaluate new phytoconstituents that provide antimycotoxigenic properties against mycotoxins. Bioactive materials chosen were fruit peels and cladodes of wild Opuntia ficus-indica containing a measurable quantity of bioactive phytochemicals. The highest concentration of bioactive metabolites was recorded for protocatechuic and t-cinnamic acids. A reduction effect of bioactives was estimated against aflatoxins, ochratoxin A and zearalenone in a simulated body system. Antifunga

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46

Popova, O. S. "Hepatoprotective effect of eugenol on laboratory rats under simulated toxicosis." Legal regulation in veterinary medicine, no. 3 (October 19, 2022): 82–83. http://dx.doi.org/10.52419/issn2782-6252.2022.3.82.

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Recently, in the literature, there is often a mention of bioflavonoid hepatoprotectors. These include: silibinin, silidianin, silicristin, isosilibinin, etc.In foreign sources, there is a mention of eugenol as a remedy that can be used as a choleretic and antitoxic agent. At present, in Russia, eugenol is used as an active antiseptic, and also has an analgesic effect.Eugenol is a pale yellow liquid with an oily consistency and a spicy aroma, slightly acidic, slightly soluble in water and highly soluble in organic solvents such as alcohol, oils, ether and chloroform.Rats (male, weight 200-250g)

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47

Petrova, M. S., A. B. Borisova, I. S. Voronova, et al. "Hydrocortisone in the treatment of severe pertussis (past to present)." Voprosy praktičeskoj pediatrii 22, no. 2 (2024): 87–91. http://dx.doi.org/10.20953/1817-7646-2024-2-87-91.

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Objective. Studying the clinical efficacy of the experimental justification of hydrocortisone use in severe pertussis. Patients and methods. The study was carried out in the State Budgetary Institution of Children's Infectious Disease Clinical Hospital No.1 of the Moscow Health Department. A total of 206 children with pertussis, aged from 0 to 3–4 months, with severe pertussis were under observation. The indication for prescribing the drug was the presence of apnea accompanied by spasmodic cough. Group I (n = 166) consisted of children who received hydrocortisone along with conventional therap

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48

Nwangwa, E.K, C.R. Nwokocha, A.O Naiho, and E.C. Adegor. "EFFECT OF Solanum lycopersicum ON THE CHANGES IN LIVER FUNCTION AND SOME HAEMATOLOGICAL PARAMETERS INDUCED BY METHYL MERCURY IN WISTER RATS." Continental J. Medical Research 5, no. 1 (2011): 22–26. https://doi.org/10.5281/zenodo.3529404.

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The antitoxic effect of <em>Solanum lycopersicum</em> on mercury poisoning in albino wistar rats was studied. Thirty-six wistar albino rats were randomly divided into six experimental groups (n=6). Group A (control) were given clean drinking water and rat chow. Group B-given rat chow +mercury (Hg) at concentration of 10ppm.Group C –given rat chow + 10% mass of <em>Solanium lycopersicum</em>(sl). Group D – given rat chow + sl + Hg at 10ppm.  Group E-given rat chow +Hg at concentration of 10ppm for 2 weeks, then stopped and administered 10% by mass of sl. Group F –given ra

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49

Ge, Yue-Bin, Yi Jiang, Huan Zhou, et al. "Antitoxic effect of Veratrilla baillonii on the acute toxicity in mice induced by Aconitum brachypodum , one of the genus Aconitum." Journal of Ethnopharmacology 179 (February 2016): 27–37. http://dx.doi.org/10.1016/j.jep.2015.12.030.

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50

Rahman, Afaf N. Abdel, Basma Ahmed Elkhadrawy, Abdallah Tageldein Mansour, et al. "Alleviating Effect of a Magnetite (Fe3O4) Nanogel against Waterborne-Lead-Induced Physiological Disturbances, Histopathological Changes, and Lead Bioaccumulation in African Catfish." Gels 9, no. 8 (2023): 641. http://dx.doi.org/10.3390/gels9080641.

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Heavy metal toxicity is an important issue owing to its harmful influence on fish. Hence, this study is a pioneer attempt to verify the in vitro and in vivo efficacy of a magnetite (Fe3O4) nanogel (MNG) in mitigating waterborne lead (Pb) toxicity in African catfish. Fish (n = 160) were assigned into four groups for 45 days. The first (control) and second (MNG) groups were exposed to 0 and 1.2 mg L−1 of MNG in water. The third (Pb) and fourth (MNG + Pb) groups were exposed to 0 and 1.2 mg L−1 of MNG in water and 69.30 mg L−1 of Pb. In vitro, the MNG caused a dramatic drop in the Pb level within

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