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Добірка наукової літератури з теми "ApoE-"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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Статті в журналах з теми "ApoE-"

1

Begcevic Brkovic, Ilijana, Benedikt Zöhrer, Markus Scholz, et al. "Simultaneous Mass Spectrometry-Based Apolipoprotein Profiling and Apolipoprotein E Phenotyping in Patients with ASCVD and Mild Cognitive Impairment." Nutrients 14, no. 12 (2022): 2474. http://dx.doi.org/10.3390/nu14122474.

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Apolipoprotein E (apoE) occurs on the majority of plasma lipoproteins and plays a major role in the lipid metabolism in the periphery and in the central nervous system. ApoE is a polymorphic protein with three common isoforms, apoE2, apoE3 and apoE4, derived from respective alleles ε2, ε3 and ε4. The aim of this study was to develop a sample pretreatment protocol combined with rapid mass spectrometry (MS)-based assay for simultaneous apolipoprotein profiling and apoE phenotype identification. This assay was validated in 481 samples from patients with stable atherosclerotic cardiovascular disea

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2

Li, Meng-Yu, Man-Ki Kwok, and Catherine Mary Schooling. "Investigating Effects of Plasma Apolipoprotein E on Ischemic Heart Disease Using Mendelian Randomization Study." Nutrients 13, no. 7 (2021): 2215. http://dx.doi.org/10.3390/nu13072215.

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Background: Observationally plasma apolipoprotein E (apoE) is positively associated with ischemic heart disease (IHD). A Mendelian randomization (MR) study suggesting apoE is unrelated to cardiovascular mortality did not consider specific isoforms. We used MR to obtain estimates of plasma apoE2, apoE3 and apoE4 on IHD, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglycerides and apolipoprotein B (apoB). Methods: We obtained independent genetic instruments from proteome genome-wide association studies (GWAS) and applied them to large outcome GWAS. We used univ

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3

Budny, Vanessa, Yannic Knöpfli, Debora Meier, et al. "APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons." Cells 13, no. 14 (2024): 1207. http://dx.doi.org/10.3390/cells13141207.

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The apolipoprotein E4 (APOE4) allele represents the major genetic risk factor for Alzheimer’s disease (AD). In contrast, APOE2 is known to lower the AD risk, while APOE3 is defined as risk neutral. APOE plays a prominent role in the bioenergetic homeostasis of the brain, and early-stage metabolic changes have been detected in the brains of AD patients. Although APOE is primarily expressed by astrocytes in the brain, neurons have also been shown as source for APOE. However, the distinct roles of the three APOE isoforms in neuronal energy homeostasis remain poorly understood. In this study, we g

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4

Yamauchi, Kazuyoshi, and Yasushi Kawakami. "The redox status of cysteine thiol residues of apolipoprotein E impacts on its lipid interactions." Biological Chemistry 401, no. 5 (2020): 617–27. http://dx.doi.org/10.1515/hsz-2019-0414.

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AbstractRedox-mediated modulation of cysteine (Cys) thiols has roles in various pathophysiological functions. We recently found that formation of disulfide-linked complexes of apolipoprotein (apo) E3 prevented apoE3 from irreversible oxidation. In this report, the influence of modification of Cys thiols in apoE2 and apoE3 on interactions with lipids was investigated. The apoE redox status was examined by a band-shift assay using a maleimide compound, and interactions with lipids were evaluated by a kinetic assay using dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and non-denaturing polyacryla

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5

HOFFMANN, MICHAEL M., HUBERT SCHARNAGL, ELEFTHERIA PANAGIOTOU, WERNER T. BANGHARD, HEINRICH WIELAND, and WINFRIED MÄRZ. "Diminished LDL Receptor and High Heparin Binding of Apolipoprotein E2 Sendai Associated with Lipoprotein Glomerulopathy." Journal of the American Society of Nephrology 12, no. 3 (2001): 524–30. http://dx.doi.org/10.1681/asn.v123524.

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Abstract. Variants of apolipoprotein E (apoE) have been linked to lipoprotein glomerulopathy, a new glomerular disease characterized by the deposition of lipoproteins in mesangial capillaries. One third of affected patients are heterozygous for apoE2 Sendai (Arg145 Pro). Variants of apoE can also produce type III hyperlipoproteinemia (HLP). Recessive type III HLP is caused by apoE2 (Arg158 Cys), a mutant with diminished low-density lipoprotein (LDL) receptor binding but halfnormal heparin binding. Dominant type III HLP is caused by mutations that markedly alter heparin binding but modestly red

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6

Vecchio, Filomena Lo, Paola Bisceglia, Bruno Pietro Imbimbo, et al. "Are apolipoprotein E fragments a promising new therapeutic target for Alzheimer’s disease?" Therapeutic Advances in Chronic Disease 13 (January 2022): 204062232210816. http://dx.doi.org/10.1177/20406223221081605.

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Human apolipoprotein E (ApoE) is a 299-amino acid secreted glycoprotein that binds cholesterol and phospholipids. ApoE exists as three common isoforms (ApoE2, ApoE3, and ApoE4) and heterozygous carriers of the ε4 allele of the gene encoding ApoE ( APOE) have a fourfold greater risk of developing Alzheimer’s disease (AD). The enzymes thrombin, cathepsin D, α-chymotrypsin-like serine protease, and high-temperature requirement serine protease A1 are responsible for ApoE proteolytic processing resulting in bioactive C-terminal-truncated fragments that vary depending on ApoE isoforms, brain region,

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7

Kurano, Makoto, Kazuhisa Tsukamoto, Eri Sakai, Masumi Hara, and Yutaka Yatomi. "Isoform-Dependent Effects of Apolipoprotein E on Sphingolipid Metabolism in Neural Cells." Journal of Alzheimer's Disease 85, no. 4 (2022): 1529–44. http://dx.doi.org/10.3233/jad-215205.

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Background: Sphingosine 1-phosphate (S1P) and ceramides have been implicated in the development of Alzheimer’s disease. Apolipoprotein E (ApoE) isoforms are also involved in the development of Alzheimer’s disease. Objective: We aimed at elucidating the potential association of the ApoE isoforms with sphingolipid metabolism in the central nervous system. Methods: We investigated the modulations of apolipoprotein M (apoM), a carrier of S1P, S1P, and ceramides in Apoeshl mice, which spontaneously lack apoE, and U251 cells and SH-SY5Y cells infected with adenovirus vectors encoding for apoE2, apoE

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8

Chung, Won-Suk, Philip B. Verghese, Chandrani Chakraborty, et al. "Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes." Proceedings of the National Academy of Sciences 113, no. 36 (2016): 10186–91. http://dx.doi.org/10.1073/pnas.1609896113.

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The strongest genetic risk factor influencing susceptibility to late-onset Alzheimer’s disease (AD) is apolipoprotein E (APOE) genotype. APOE has three common isoforms in humans, E2, E3, and E4. The presence of two copies of the E4 allele increases risk by ∼12-fold whereas E2 allele is associated with an ∼twofold decreased risk for AD. These data put APOE central to AD pathophysiology, but it is not yet clear how APOE alleles modify AD risk. Recently we found that astrocytes, a major central nervous system cell type that produces APOE, are highly phagocytic and participate in normal synapse pr

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9

Pohlkamp, Theresa. "Apolipoprotein E: Cholesterol metabolism and Alzheimer’s pathology." Neuroforum 26, no. 1 (2020): 25–30. http://dx.doi.org/10.1515/nf-2019-0030.

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AbstractAge is the greatest risk factor for Alzheimer’s disease (AD). Today, due to an increase in global life expectancy, AD-related deaths are ranked as the sixth most common cause of death. The allele isoform ɛ4 of apolipoprotein E (ApoE4) is the most important genetic risk factor for AD. Three ApoE isoforms are common in humans: ApoE2, ApoE3, and ApoE4. ApoE3 is the most frequent isoform and considered neutral with regards to AD, whereas the isoform ApoE2 is protective. Thus it is important to understand how ApoE isoforms affect amyloid-β (Aβ) and tau toxicity, the key drivers of AD pathol

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10

Iannucci, Jaclyn, Abhik Sen, and Paula Grammas. "Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro." Current Issues in Molecular Biology 43, no. 1 (2021): 215–25. http://dx.doi.org/10.3390/cimb43010018.

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Mutations to the cholesterol transport protein apolipoprotein E (ApoE) have been identified as a major risk factor for the development of sporadic or late-onset Alzheimer’s disease (AD), with the e4 allele representing an increased risk and the rare e2 allele having a reduced risk compared to the primary e3 form. The reasons behind the change in risk are not entirely understood, though ApoE4 has been connected to inflammation and toxicity in both the brain and the periphery. The goal of this study was to better understand how the ApoE isoforms (ApoE2/3/4) confer differential AD-related risk by

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Дисертації з теми "ApoE-"

1

Dinkel, Regina Elke. "In-vivo Metabolismus der VLDL-Apolipoproteine ApoB, ApoCIII und ApoE." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-3562.

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Reverté, Soler Ingrid. "Neurobehavioural effects associated with postnatal exposure to decabromodiphenyl ether in apoe2, apoe3 and apoe4 transgenic mice." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/76782.

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El Decabromodifenil èter (BDE-209) és un retardant de la flama àmpliament utilitzat i font de preocupació a causa de la toxicitat mostrada per altres Difenil Èters Polibromats (PBDEs). La presència de PBDEs en la llet materna fa preocupant la seva exposició durant el desenvolupament. Pensem que l’exposició primerenca a BDE-209 pot produir efectes a llarg termini i interactuar amb factors genètics, com el genotip de l’ApolipoproteinaE. Ratolins portadors de les diferents isoformeshumanes de l’ApoE foren tractats amb una dosi oral aguda de 0, 10 o 30 mg / kg de BDE-209 en el dia postnatal 10 i

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3

Cambon, Karine. "Influence of ApoE polymorphism on synaptic morphometry during aging in the dentate gyrus of ApoE knockout and human ApoE transgenic mice." Thesis, [n.p.], 2000. http://oro.open.ac.uk/19118/.

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4

Lundbäck, Daniel. "Alkoholkonsumtion och episodiskt minne.Kan APOE genen vid olika konsumtionsnivåer ha betydelse?" Thesis, Stockholms universitet, Psykologiska institutionen, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-88448.

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I denna studie undersöktes om relationen mellan alkoholkonsumtion och episodiskt minne skiljer sig beroende på vilken allele av APOE genen en person har. Undersökningsdeltagarna delades upp i fyra grupper, medelålders män, medelålders kvinnor, äldre män och äldre kvinnor. Utbildningsnivå och ålder inom varje åldersgrupp användes som kovariat. APOE delades upp på 4 bärare och icke bärare. Några signifikanta interaktionseffekter mellan alkoholkonsumtion och APOE framkom inte i någon grupp. I gruppen medelåldersmän hittades en signifikant huvudeffekt av alkoholkonsumtion, där de som avstod från

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5

Hua, Jennifer. "Rôle des récepteurs P2X4 dans la dégradation d’ApoE : implication dans la maladie d’Alzheimer." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT021/document.

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Les récepteurs purinergiques P2X4 (P2X4R) sont des récepteurs canaux exprimés par lesneurones et les microglies du système nerveux central et sont impliqués dans de nombreuxprocessus physiologiques et pathologiques. Des études préliminaires, menées au sein dulaboratoire, ont permis de mettre en évidence une interaction entre P2X4R etl’Apolipoprotéine E (ApoE), ainsi qu’une augmentation d’ApoE dans les macrophages et lesmicroglies provenant de souris déficientes pour P2X4R. Basée sur ces observations, lapremière partie de cette thèse a cherché à caractériser les mécanismes impliquant P2X4R dans

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6

Wassef, Hanny. "Synthesis and secretion of apoC-I and apoE by human SW872 liposarcoma cells." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82447.

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Apolipoprotein C-I (apoC-I) plays an important role in the metabolism of plasma triglyceride levels and cholesterol metabolism. Little is known about the regulation of apoC-I production by human adipocytes. Aim. To investigate the effect of different tissue culture conditions on the synthesis and secretion of apoC-I and apoE in human SW872 liposarcoma cells and to study the effects of apoC-I overexpression in these same cells. Methods. SW872 cells were grown in DMEM/F-12 (3:1, v/v). QPCR was used to quantify mRNA synthesis. ELISAs were used to quantify intracellular and extracellular pr

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7

Sleiman, Lyne. "The Role of cIAP2 in Early and Late Atherosclerosis Lesion Development." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20226.

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Cellular Inhibitor of Apoptosis 2 (cIAP2) belongs to the IAP family, a group of endogenous proteins that inhibit apoptosis. However, the physiological role of cIAP2 remains poorly defined. Knock-out (KO) and wild type (WT) mice were used to examine the effect of cIAP2 protein on the progression of atherosclerosis in apoE -/- mice. Following the high-fat diet period of 4 and 12 wks, tissues were harvested and analysis focused on the aortic root, the aortic arch, the descending aorta, and the blood. Ex vivo results show a significant decrease in aortic arch lesion area in KO vs. WT in both study

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8

D'EUGENIO, Ottavio. "VALUTAZIONE DI FATTORI DI RISCHIO GENETICI SU BASE POLIMORFICA NELLA MALATTIA DI ALZHEIMER." Doctoral thesis, La Sapienza, 2006. http://hdl.handle.net/11573/917163.

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9

Evans, Vanessa. "Intramuscular gene transfer of apolipoprotein E (ApoE) to reverse hyperlipidaemia and atherosclerosis in ApoE-deficient mice." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444704/.

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Plasma ApoE has multiple atheroprotective actions, including clearance of cholesterol-rich remnant lipoproteins, and is an attractive gene therapy candidate to treat atherosclerosis. Here, I focus on the single intramuscular injection of an ApoE-expressing vector, non-viral DNA (plasmid) or adeno-associated virus (AAV), as a safe and effective treatment to alleviate hypercholesterolaemia and atherosclerosis in ApoE-deficient (ApoE" ") mice. Firstly, I constructed expression plasmids harbouring human ApoE3 cDNA, driven by two muscle-specific (CK6 and C512) and one ubiquitous (CAG) promoter. The

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10

Rantsi, P. (Petra). "Apoe 4-alleelien rooli saamelaisväestön muistisairauksissa." University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201711083079.

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Alzheimerin tauti (AT) on yleisin etenevä muistisairaus. Eteneviin muistisairauksiin luetaan myös aivoverenkiertosairauden muistisairaus, Lewyn kappale- patologiaan liittyvät aivoja rappeuttavat sairaudet ja otsa-ohimolohkorappeumat. Elimistön rasva- aineenvaihduntaan liittyvän apolipoproteiini E4- (ApoE4) alleelin on todettu olevan sydän- ja verisuonisairauksien, kuten myös AT:n myöhemmällä iällä alkavan muodon geneettinen riskitekijä. ApoE4-alleelin yhteyttä muihin eteneviin muistisairauksiin ei ole osoitettu. Vaikka ApoE4:n roolia muistisairauksien ja etenkin AT:n riskitekijänä on tutkittu

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Книги з теми "ApoE-"

1

Kanta, Chandra. Apne-Apne Konark. [s.n.], 1995.

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2

Goyal, Ajay. Apne apne dukh. Shirshak, 1987.

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Ajneya. Apne apne ajnabee. Bhartiya Jnanpith Parkashan, 1998.

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4

Singh, Bhagwan. Apne apne Ram. Manaka, 1992.

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5

Hashmi, Jamila. Apne Apne Rang. Star, 1990.

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6

McPherran, Mark L., ed. Plato's 'Republic'. Cambridge University Press, 2010. http://dx.doi.org/10.1017/cbo9780511763090.

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Bobonich, Christopher, ed. Plato's 'Laws'. Cambridge University Press, 2010. http://dx.doi.org/10.1017/cbo9780511781483.

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Denis, Lara, ed. Kant's 'Metaphysics of Morals'. Cambridge University Press, 2010. http://dx.doi.org/10.1017/cbo9780511763250.

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Melamed, Yitzhak Y., and Michael A. Rosenthal, eds. Spinoza's 'Theological-Political Treatise'. Cambridge University Press, 2010. http://dx.doi.org/10.1017/cbo9780511781339.

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Arnon, Ilana, Jim Cottrill, Ed Dubinsky, et al. APOS Theory. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-7966-6.

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Частини книг з теми "ApoE-"

1

Scherrmann, Jean-Michel, Kim Wolff, Christine A. Franco, et al. "APOE." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4065.

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Whang, William. "Apolipoproteins: APOA-I, APOA-IV, APOE." In Encyclopedia of Behavioral Medicine. Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-39903-0_1245.

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Abrams, David B., J. Rick Turner, Linda C. Baumann, et al. "Apolipoproteins: APOA-I, APOA-IV, APOE." In Encyclopedia of Behavioral Medicine. Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1005-9_1245.

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Whang, William. "Apolipoproteins: APOA-I, APOA-IV, APOE." In Encyclopedia of Behavioral Medicine. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4614-6439-6_1245-2.

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5

Belayev, Ludmila, Carlos M. Vieira, Reinaldo B. Oria, and Nicolas G. Bazan. "ApoE and Cerebrovascular Disease." In Apolipoprotein E. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-52641-1_60-1.

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Shi, Weibin. "ApoE, Atherosclerosis, and Hypercholesterolemia." In Apolipoprotein E. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-52641-1_26-1.

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Correas, A. G., K. Stromsnes, R. I. Lupu, and G. Olaso-Gonzalez. "APOE and Oxidative Stress." In Apolipoprotein E. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-52641-1_29-1.

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Montenegro, Raquel Carvalho, Pedro Filho Noronha de Souza, and Felipe Pantoja Mesquita. "APOE and Cancer Immunology." In Apolipoprotein E. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-52641-1_34-1.

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Pradier, L., C. Czech, L. Mercken, et al. "App, Apoe, and Presenilin Transgenics." In Advances in Behavioral Biology. Springer US, 1998. http://dx.doi.org/10.1007/978-1-4615-5337-3_5.

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10

Yamamoto, Tokuo. "Receptors for Apoe-Containing Lipoproteins." In Drugs Affecting Lipid Metabolism. Springer Netherlands, 1996. http://dx.doi.org/10.1007/978-94-009-0311-1_34.

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Тези доповідей конференцій з теми "ApoE-"

1

Grah, Vitor Matias, Guilherme Sampaio Silva, Karla Viana Rezende, et al. "The relationship between apolipoprotein e4 and bloodbrain barrier dysfunction in Alzheimer Disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.091.

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Background: Alzheimer disease(AD) is a progressive neurodegenerative dysfunction with a cognitive deficit and amyloid-β(Aβ) accumulation. That said, the apolipoprotein E (ApoE) has 4 variants, with E4 being linked to decreased cerebral blood flow and fragile blood-brain barrier (BBB). In this way, the BBB has an important role in removing substances that are toxic to the brain such as βA protein. Objective: Demonstrate the relationship of ApoE4 and BBB dysfunction in the pathophysiology of AD. Methods: Bibliographic review using the CAPES journals portal, in the last 5 years. Results: After an

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Vengrenyuk, Yuliya, Theodore J. Kaplan, Luis Cardoso, Gwendalyn J. Randolph, and Sheldon Weinbaum. "Biomechanical Modeling of Atherosclerotic Lesions in ApoE Deficient Mice." In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206571.

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Cardiovascular disease remains the principal killer in the western world despite major advances in treatment of its patients [1]. It is generally accepted that sudden rupture of vulnerable plaque followed by thrombus formation underlies most cases of myocardial infarction and is responsible for more than a half of 500,000 coronary heart disease deaths every year. Although histopathological analysis of postmortem specimens have provided important data on histological features of ruptured human plaques, there is an urgent need for good representative animal models of plaque rupture. Over the las

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3

Yang, Jitao. "ApoE Genetic Testing and Personalized Nutrition Service." In ISAIMS 2024: 2024 5th International Symposium on Artificial Intelligence for Medicine Science. ACM, 2024. https://doi.org/10.1145/3706890.3707014.

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Silva, Letícia Freitas de Castro, Elisa Pinheiro Weber, Gleice Silva Toledo, and Josiane Fonseca Almeida. "New pharmacological strategies for the treatment of alzheimer’s disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.097.

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Introduction: Alzheimer’s disease (AD) is seen as the most important dementia, prevalent in the elderly over 60 years old. There is still no cure, and the pharmacological strategies are to delay the symptoms and development of the pathology. The pathophysiological mechanisms are: hyperphosphorylation of the tau protein and aggregation of amyloid-β. Update studies of the tested therapies target the main pathological mechanisms: accumulation of β amyloid (inhibitors and modulators of β-secretase and γ-secretase and active and passive anti-Aβ immunotherapies), tau protein (inhibition of abnormal

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Li, Ziying. "New APOE-related therapeutic options for Alzheimer’s disease." In INTERNATIONAL CONFERENCE ON FRONTIERS OF BIOLOGICAL SCIENCES AND ENGINEERING (FBSE 2018). Author(s), 2019. http://dx.doi.org/10.1063/1.5085515.

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"APOE Gene Expression in Patients with Alzheimer’s Disease." In International Conference on Cellular & Molecular Biology and Medical Sciences. Universal Researchers (UAE), 2016. http://dx.doi.org/10.17758/uruae.ae0916409.

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Wang, Ying, John A. Johnson, Abigail Fulp, Michael A. Sutton, and Susan M. Lessner. "Adhesive Strength of Atherosclerotic Plaques Depends on Collagen Content." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80433.

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Atherosclerotic plaque rupture is a major cause of myocardial infarction, coronary thrombosis and stroke. In a previous study, we proposed a new plaque rupture mechanism, plaque separation at the shoulder, and developed a novel quantitative mechanical test to measure the adhesive strength between the atherosclerotic plaque and the underlying vascular wall in mouse models using the local energy release rate, G, as a quantifiable metric for direct comparison of plaque separation strengths (1). We have now investigated structure-function relationships between the local energy release rate and loc

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Tavares-Junior, José Wagner Leonel, Danilo Oliveira Nunes, Manoel Alves Sobreira-Neto, and Pedro Braga-Neto. "Long COVID cognitive impairment: clinical and apoe genotyping characterization." In Reunião de Pesquisadores em Doença de Alzheimer e Desordens Relacionadas. Academia Brasileira de Neurologia, 2024. http://dx.doi.org/10.22491/19805764/042.

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"Methylation and expression profiles in Apoe vicinity point to specific neighboring interaction of Apoe and TOMM40 genes: implication for the Alzheimer disease." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-127.

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Tavares-Junior, Jose Wagner, Pedro Braga-Neto, Manoel Sobreira Neto, et al. "LONG-COVID COGNITIVE IMPAIRMENT: COGNITIVE ASSESSMENT AND APOLIPOPROTEIN E (APOE) GENOTYPING CORRELATION IN A BRAZILIAN COHORT." In XIII Meeting of Researchers on Alzheimer's Disease and Related Disorders. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1980-5764.rpda030.

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Background: COVID-19 neurological manifestations were demonstrated during the pandemic, including cognitive impairment. Objectives: To determine the prevalence of cognitive and behavioral complaints (such as dementia, MCI or SCD) in a outpatient sample with recent SARS-COV2 infection. Specific: Evaluate the association of cognitive impairment with the presence of the polymorphism found in the APOE gene and with respiratory disease. Methodology: Observational, longitudinal, prospective clinical study. Inclusion criteria: patients with confirmed Covid-19. Patients are evaluated in an outpatient

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Звіти організацій з теми "ApoE-"

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ตั้งวงษ์ไชย, สุขเจริญ, โสฬพัทธ์ เหมรัญช์โรจน์, ยุทธชัย ลิขิตเจริญ, พวงสร้อย วรกุล, สุภัทรพร เทพมงคล та ชาวิท ตันวีระสกุลชัย. โครงการวิจัยพัฒนาแบบประเมิน CERAD เพื่อการวินิจฉัยและลงทะเบียนผู้ป่วยอัลไซเมอร์ไทย. จุฬาลงกรณ์มหาวิทยาลัย, 2015. https://doi.org/10.58837/chula.res.2015.31.

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แบบประเมิน CERAD (The Consortium to Establish a Registry for Atzheimer's Disease) เป็นเครื่องมือที่ใช้ในการประเมินผู้ป่วยโรคสมองเสื่อมชนิดอัลไซเมอร์ที่ใช้กันอย่างแพร่หลาย ให้ข้อมูลของ cognition ในด้านต่าง ๆ ของผู้ป่วย แบบประเมินส่วน neuropsychological battery ช่วยในการวินิจฉัยและติดตามผลการรักษาผู้ป่วยในระยะยาวได้ โครงการนี้มีวัตถุประสงค์จะพัฒนาแบบประเมิน CERAD เป็นภาษาไทย หาค่าความเที่ยงตรงและความน่าเชื่อถือของแบบประเมิน พัฒนาแบบประเมินเป็นฉบับอิเล็กโทรนิกส์ที่สามารถกรอกข้อมูลผู้ป่วยผ่านระบบอินเตอร์เน็ตออนไลน์ และหาความชุกของยีน ApoE 4 ในผู้ป่วยโรคสมองเสื่อมชนิดอัลไซเมอร์ไทย

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Nomura, Koji, and Mun S. Ho. APO Productivity Databook 2024. Asian Productivity Organization, 2024. http://dx.doi.org/10.61145/sqvz2821.

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The 17th edition of the APO Productivity Databook offers in-depth analyses of economic growth and productivity in Asia from 1970 to 2022, with projections extending to 2035. It covers baseline indicators for 31 Asian economies, including 21 APO members, 10 nonmembers, and reference economies such as Australia, the EU, France, Germany, Italy, New Zealand, the UK, and the USA. A detailed productivity account in the APO Productivity Database (APO-PDB) is developed for 21 APO members, four nonmember Asian countries, and the USA, with detailed insights on the roles of capital and labor inputs and t

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Nomura, Koji, and Fukunari Kimura. APO Productivity Databook 2018. Asian Productivity Organization, 2018. https://doi.org/10.61145/gais2432.

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Projections of economic growth and labor quality changes in member countries up to 2030 are new features of the 2018 APO Productivity Databook, with expanded total factor productivity estimates and city productivity coverage, taking the effects of the smart digital revolution into account. Detailed analyses of productivity and economic performance in Asia-Pacific and reference economies enable comparisons at different development stages. These precise productivity measurements are part of APO efforts to improve policymaking, contributing to higher standards of living.

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Conte, Ianina, Mary Turner, Iris Fineberg, et al. Community-based evaluation of 'Preferred Place of Care' in the North West of England. National Institute for Health Research, 2022. http://dx.doi.org/10.3310/nihropenres.1115172.1.

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Young, Ron, ed. APO Knowledge Management Facilitators Guide. Asian Productivity Organization, 2020. http://dx.doi.org/10.61145/qhqt9093.

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The new second edition of the APO Knowledge Management Facilitatorsâ€™ Guide (KMFG) reflects the updated APO KM Framework, ISO 30301 Knowledge Management Standard, and Industry 4.0 smart technology adoption. The five revised modules show how to navigate the transition to a digital society, manage change and knowledge, and remain agile, sustainable, and productive. The updated 42-item KM Assessment Tool in the KMFG Appendix is invaluable for KM consultants serving public- and private-sector clients in different socioeconomic settings.

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Webber, Franklin, Partha P. Pal, Michael Atighetchi, Chris Jones, and Paul Rubel. Applications That Participate in Their Own Defense (APOD). Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada415561.

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Lin, Dr Chun-Hsu. APO Green Productivity 2.0: The Road Ahead. Asian Productivity Organization, 2024. http://dx.doi.org/10.61145/maof9737.

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The report presents a comprehensive roadmap to drive sustainability through Green Productivity (GP) 2.0 initiatives. Packed with actionable strategies, technological interventions, and forward-thinking approaches, it empowers policymakers, businesses, and professionals to fuel economic growth while safeguarding the environment. Readers will gain insights into how the GP 2.0 ecosystem and projects contributes to shaping the future of sustainable development across industries, fosters innovation, and builds resilient, eco-friendly economies for a greener tomorrow.

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Boothman, David A. Nuclear apoJ: An X-ray-inducible cell death signal. Final Report. Office of Scientific and Technical Information (OSTI), 2003. http://dx.doi.org/10.2172/824533.

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Chien, Chen-Fu, ed. Assessment of Smart Manufacturing in APO Member Countries. Asian Productivity Organization, 2020. http://dx.doi.org/10.61145/jtvh5616.

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Hiep, Ha Minh, ed. Innovation Readiness Assessment in Selected APO Member Economies. Asian Productivity Organization, 2022. http://dx.doi.org/10.61145/seap1749.

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The journey in the pursuit of innovation and digital technologies may be rife with uncertainties and anxiety for businesses and industries, especially the SMEs. At whatever stage of innovation an organization might be at, this publication provides an excellent guide and roadmap to assess, implement, and achieve innovation in business. Using the ISO 56000 Innovation Management System, enterprises have a solid reference to models and best practices from 10 APO member economies. This will help them to move forward in offering value-added products and services to the market while elevating and enh

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