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1

Abolhasani, Milad, Nicholas C. Bruno, and Klavs F. Jensen. "Oscillatory three-phase flow reactor for studies of bi-phasic catalytic reactions." Chemical Communications 51, no. 43 (2015): 8916–19. http://dx.doi.org/10.1039/c5cc02051d.

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Анотація:
Oscillatory flow reactor strategy removes the mixing, mass transfer and residence time limitations associated with continuous multi-phase flow approaches for studies of bi-phasic C–C and C–N catalytic reactions.
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2

Moran, Paul R. "4654591 NMR flow imaging using bi-phasic excitation field gradients." Magnetic Resonance Imaging 5, no. 5 (1987): II. http://dx.doi.org/10.1016/0730-725x(87)90139-1.

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3

Gasmi, S., and F. Z. Nouri. "A study of a bi-phasic flow problem in porous media." Applied Mathematical Sciences 7 (2013): 2055–64. http://dx.doi.org/10.12988/ams.2013.13185.

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4

Sharma, Prerna, P. Aswathi, Anit Sane, Shankar Ghosh, and S. Bhattacharya. "Three-dimensional real-time imaging of bi-phasic flow through porous media." Review of Scientific Instruments 82, no. 11 (2011): 113704. http://dx.doi.org/10.1063/1.3658822.

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5

Elangovan, T., D. Mangalaraj, K. Prabakar, P. Kuppusami, Shabana Khan, and E. Mohandas. "Microstructure Analysis of TaN/Cu Nanocomposite Coatings Deposited by Pulsed DC Magnetron Sputtering." Advanced Materials Research 123-125 (August 2010): 427–30. http://dx.doi.org/10.4028/www.scientific.net/amr.123-125.427.

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TaN-Cu nanocomposite thin films used as materials for thin-film resistors (TFR) were prepared by magnetron pulsed dc reactive sputtering. Structural and morphological properties of films deposited on (100) Si as a function of nitrogen flow rate and substrate temperature is investigated. With the introduction of N2 gas flow indicated with different phases of nanocrystalline h-Ta, Ta2N, TaN, Ta4N5 and Cu. XRD analysis of the films deposited with increasing substrate temperature at constant flow rate of nitrogen 10 sccm indicated that the nanocrystalline with bi-phasic (fcc-TaN and fcc-Cu). The m
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6

Yang, H., D. C. Florence, E. L. McCoy, W. A. Dick, and P. S. Grewal. "Design and hydraulic characteristics of a field-scale bi-phasic bioretention rain garden system for storm water management." Water Science and Technology 59, no. 9 (2009): 1863–72. http://dx.doi.org/10.2166/wst.2009.186.

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A field-scale bioretention rain garden system was constructed using a novel bi-phasic (i.e. sequence of anaerobic to aerobic) concept for improving retention and removal of storm water runoff pollutants. Hydraulic tests with bromide tracer and simulated runoff pollutants (nitrate-N, phosphate-P, Cu, Pb, and Zn) were performed in the system under a simulated continuous rainfall. The objectives of the tests were (1) to determine hydraulic characteristics of the system, and (2) to evaluate the movement of runoff pollutants through the system. For the 180 mm/24 h rainfall, the bi-phasic bioretenti
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7

Barranco, David, Leslie N. Sutton, Sandra Florin, et al. "Use of 19F NMR Spectroscopy for Measurement of Cerebral Blood Flow: A Comparative Study Using Microspheres." Journal of Cerebral Blood Flow & Metabolism 9, no. 6 (1989): 886–91. http://dx.doi.org/10.1038/jcbfm.1989.122.

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19F NMR was used to determine washout curves of an inert, diffusible gas (CHF3) from the cat brain. The cerebral blood flow was estimated from a bi- or tri-phasic fit to the deconvoluted wash-out curve, using the Kety-Schmidt approach. Cerebral blood flow values determined by 19F NMR show the expected responsiveness to alterations in Paco2, but are approximately 28% lower than cerebral blood flow values determined simultaneously by radioactive microsphere techniques. High concentrations of CHF3 have little effect on intracranial pressure, mean arterial blood pressure or Paco2, but cause small
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8

Jian, Ranran, Zhonghe Shi, Haichao Liu, Weimin Yang, and Mohini Sain. "Enhancing Mixing and Thermal Management of Recycled Carbon Composite Systems by Torsion-Induced Phase-to-Phase Thermal and Molecular Mobility." Polymers 12, no. 4 (2020): 771. http://dx.doi.org/10.3390/polym12040771.

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A novel torsion screw has been proposed to resolve the inadequate control of mass transfer and the thermal management of two component polymer blends and their carbon fiber composites. The novel torsional screw distinctly introduced radial flow in the torsion screw channel, which is a significant improvement over the flow pattern developed by the conventional screw. The heat transfer and mixing behavior of melt mixtures are enhanced by adapting screws with torsion elements compared with the traditional screw elements. Heat transfer efficacy in the polypropylene–polystyrene bi-phasic extrusion
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9

Nicolas Receveur, Dmitry Nechipurenko, Yannick Knapp, et al. "Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner." Haematologica 105, no. 10 (2019): 2471–83. http://dx.doi.org/10.3324/haematol.2019.235754.

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Blood flow profoundly varies throughout the vascular tree due to its pulsatile nature and to the complex vessel geometry. While thrombus formation has been extensively studied in vitro under steady flow, and in vivo under normal blood flow conditions, the impact of complex hemodynamics such as flow acceleration found in stenosed arteries has gained increased appreciation. We investigated the effect of flow acceleration, characterized by shear rate gradients, on the function of platelets adhering to fibrinogen, a plasma protein which plays a key role in hemostais and thrombosis. While we confir
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10

Gonawan, Fadzil Noor, and Azlina Harun Kamaruddin. "Conceptual Study of Transesterification of Vegetable Oils in the Continuous-Stirred-Tank Reactor at Unsteady-State and Isothermal Conditions." Malaysian Journal of Fundamental and Applied Sciences 17, no. 2 (2021): 181–94. http://dx.doi.org/10.11113/mjfas.v17n2.2006.

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The continuous-stirred-tank reactor (CSTR) is favorable for bi-phasic enzymatic reaction due to ease of operation, cost-effective and low downtime. Lack of study on the enzymatic reaction in the CSTR has disfavor this type of reactor compared to batch and packed bed. Presently, a simulation was carried out to simulate the behavior of the lipase-catalyzed production of biodiesel by using CSTR at isothermal conditions. The mathematical model incorporated the effect of the kinetic, thermal, and operating parameters. The parameters such as Michaelis constant (Km), inhibition constant (Ki), Gibbs i
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11

Lungu, Adrian. "A DES-SST Based Assessment of Hydrodynamic Performances of the Wetted and Cavitating PPTC Propeller." Journal of Marine Science and Engineering 8, no. 4 (2020): 297. http://dx.doi.org/10.3390/jmse8040297.

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The paper describes an investigation of the hydrodynamic performances of a five-bladed controllable pitch propeller, whose geometry was provided by Schiffbau-Versuchsanstalt (SVA) Potsdam GmbH Model Basin. Both cavitating and non-cavitating regimes are numerically simulated for different advance ratio coefficients. The numerical approach is based on a finite volume approach in which closure to the turbulence is achieved through detached eddy simulation (DES). Propeller open water (POW) characteristics are computed, and the numerical solutions are validated through extensive comparisons with ex
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12

Pillarella, M. R., and A. L. Zydney. "Theoretical Analysis of the Effect of Convective Flow on Solute Transport and Insulin Release in a Hollow Fiber Bioartificial Pancreas." Journal of Biomechanical Engineering 112, no. 2 (1990): 220–28. http://dx.doi.org/10.1115/1.2891175.

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The bioartificial pancreas, in which transplanted pancreatic tissue or isolated cells are cultured on a hollow fiber membrane, is an attractive approach to restore physiologic insulin delivery in the treatment of diabetes. Insulin response in prototype devices has been unacceptable due to the large mass transport limitations associated with the membrane and the surrounding shell region. Although available theoretical analyses provide some insight into the combined effects of transport and reaction in the bioartificial pancreas, they cannot quantitatively account for the effects of convective r
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13

Messina-Graham, Steven, and Hal E. Broxmeyer. "SDF-1/CXCL12 Modulates Mitochondrial Respiration of Hematopoietic Stem and Progenitor Cells in a Bi-Phasic Manner." Blood 126, no. 23 (2015): 2389. http://dx.doi.org/10.1182/blood.v126.23.2389.2389.

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Abstract SDF-1, also known as CXCL12, is a potent and well-characterized chemokine required for the homing and engraftment of hematopoietic stem and progenitor cells (HSPCs) during hematopoietic stem cell transplantation (Sharma et al., 2011, Stem Cells Dev., 6:933) as well as HSC maintenance in the bone marrow (Greenbaum et al., 2013, Nature, 495:227). Data from our group has shown that in an SDF-1/CXCL12 transgenic mouse model, Lineage- Sca-1+ c-Kit+ (LSK) bone marrow cells have reduced mitochondrial membrane potential versus wild-type (Mantel et al., 2010, Cell Cycle, 9:2008). These results
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14

Sajjan, Kiran, N. Ameer Ahammad, C. S. K. Raju, M. Karuna Prasad, Nehad Ali Shah, and Thongchai Botmart. "Study of nonlinear thermal convection of ternary nanofluid within Darcy-Brinkman porous structure with time dependent heat source/sink." AIMS Mathematics 8, no. 2 (2023): 4237–60. http://dx.doi.org/10.3934/math.2023211.

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<abstract> <p>The dynamical behaviour and thermal transportation feature of mixed convective Casson bi-phasic flows of water-based ternary Hybrid nanofluids with different shapes are examined numerically in a Darcy- Brinkman medium bounded by a vertical elongating slender concave-shaped surface. The mathematical framework of the present flow model is developed properly by adopting the single-phase approach, whose solid phase is selected to be metallic or metallic oxide nanoparticles. Besides, the influence of thermal radiation is taken into consideration in the presence of an inter
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15

Laille, E., R. Ward, A. Nasser, et al. "The pharmacokinetics of azacitidine following subcutaneous treatment in patients with myelodysplastic syndromes (MDS) or acute myelogenous leukemia (AML)." Journal of Clinical Oncology 27, no. 15_suppl (2009): 7087. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.7087.

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7087 Background: 5-azacitidine (AZA), through its effects on DNA metabolism, gene expression, and cell differentiation, has proven beneficial in treatment of MDS and AML and AZA therapy significantly increases survival in higher-risk MDS and AML compared to conventional care. Few studies have evaluated the pharmacokinetics (PK) of AZA and the renal elimination of AZA has not been previously published to our knowledge. Plasma PK of AZA are herein reported in patients receiving SC doses of 75 mg/m2. This study was designed to also assess the contribution of renal elimination to the overall clear
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16

Nodland, Sonja E., Anna A. Bajer, and Tucker W. LeBien. "Charting the Early Stages of Human B Lymphopoiesis Using the IL-7 Receptor as a Navigational Marker." Blood 114, no. 22 (2009): 95. http://dx.doi.org/10.1182/blood.v114.22.95.95.

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Abstract Abstract 95 The identity and developmental potential of human lymphoid progenitors (LP) restricted to differentiate into T, B and/or NK cells at the exclusion of myeloid/erythroid lineages is not completely understood. Although LP from cord blood and marrow been described, there is no consensus as to the phenotype of LP committed to the B-lineage from either tissue source, or the identity of the cytokine signals that regulate lineage commitment of these progenitors. Resolution of this question has implications for identifying potential leukemic stem cells in acute lymphoblastic leukem
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17

MacBeth, Kyle J., Eric Laille, Yuhong Ning, et al. "A Comparative Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluation of Azacitidine Following Subcutaneous (SC) and Oral Administration in Subjects with Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML), Results From a Phase 1 Study." Blood 114, no. 22 (2009): 1772. http://dx.doi.org/10.1182/blood.v114.22.1772.1772.

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Abstract Abstract 1772 Poster Board I-798 Background Parenteral azacitidine significantly improves overall survival in patients with higher-risk MDS and WHO AML (20-30% blasts) compared to conventional care (Fenaux, Lancet Oncol 2009;10:223). An oral azacitidine formulation is in development. A Phase 1, “3+3”, dose-escalation study was designed to determine the maximum tolerated dose (MTD), dose limiting toxicities (DLTs), safety, PK and PD profiles of SC and increasing doses of orally-administered azacitidine in subjects with MDS or AML (not candidates for other therapies) by WHO criteria. In
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18

Pinho, Bruno, Lindsay M. Williams, Julien Mahin, Yunhu Gao, and Laura Torrente-Murciano. "Enhancing mixing efficiency in curved channels: A 3D study of bi-phasic Dean-Taylor flow with high spatial and temporal resolution." Chemical Engineering Journal, June 2023, 144342. http://dx.doi.org/10.1016/j.cej.2023.144342.

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19

O’Neill, Brian, Timothy P. Quinn, Victor Frenkel, and King C. P. Li. "A Multi-Phasic, Continuum Damage Mechanics Model of Mechanically Induced Increased Permeability in Tissues." MRS Proceedings 898 (2005). http://dx.doi.org/10.1557/proc-0898-l02-05.

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AbstractRecently, we have reported enhanced permeability of tissues due to in vivo treatment with pulsed high intensity focused ultrasound (pHIFU). This new therapy has shown promise as a way of increasing the penetration of large drug molecules, both out of the vasculature and through the tissue. To date, no clear physical model of tissue exists that can account for these effects.A new model is proposed that clearly establishes the link between tissue structure and fluid flow properties on one hand, and the history of applied mechanical forces on the other. The model draws inspiration from tw
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20

Cuypers, Fabian, Alexander Schäfer, Sebastian B. Skorka, et al. "Innate immune responses at the asymptomatic stage of influenza A viral infections of Streptococcus pneumoniae colonized and non-colonized mice." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-00211-y.

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AbstractSeasonal Influenza A virus (IAV) infections can promote dissemination of upper respiratory tract commensals such as Streptococcus pneumoniae to the lower respiratory tract resulting in severe life-threatening pneumonia. Here, we aimed to compare innate immune responses in the lungs of healthy colonized and non-colonized mice after IAV challenge at the initial asymptomatic stage of infection. Responses during a severe bacterial pneumonia were profiled for comparison. Cytokine and innate immune cell imprints of the lungs were analyzed. Irrespective of the colonization status, mild H1N1 I
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21

Kick, Andrew R., Amanda F. Amaral, Alba Frias-De-Diego, et al. "The Local and Systemic Humoral Immune Response Against Homologous and Heterologous Strains of the Type 2 Porcine Reproductive and Respiratory Syndrome Virus." Frontiers in Immunology 12 (March 9, 2021). http://dx.doi.org/10.3389/fimmu.2021.637613.

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Анотація:
The humoral immune response plays a crucial role in the combat and protection against many pathogens including the economically most important, highly prevalent, and diverse pig pathogen PRRSV – the Porcine Reproductive and Respiratory Syndrome Virus. In addition to viremia and viral shedding analyses, this study followed the local and systemic humoral immune response of pigs for 63 days upon inoculation with one of three types of Type-2 PRRSV (PRRSV-2) strains – one modified live virus (MLV) vaccine strain, and two lineage 1 PRRSV-2 strains, NC134 and NC174. The local response was analyzed by
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22

Lyle, Alicia N., Ebony W. Remus, Aaron E. Fan, and W. Robert Taylor. "Abstract 202: Hydrogen Peroxide Increases Osteopontin Expression Through Activation of Transcriptional and Translational Pathways." Arteriosclerosis, Thrombosis, and Vascular Biology 32, suppl_1 (2012). http://dx.doi.org/10.1161/atvb.32.suppl_1.a202.

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Анотація:
The occlusion of blood vessels in the setting of cardiovascular disease leads to ischemia, initiating processes that promote neovascularization to restore blood flow and preserve tissue function. Our in vivo studies show that Osteopontin (OPN) is a critical mediator of post-ischemic neovascularization and that ischemia-induced increases in OPN expression are H 2 O 2 -dependent. However, the mechanisms by which H 2 O 2 increases OPN expression are poorly defined. To determine if H 2 O 2 mediates transcriptional, post-transcriptional, and/or translational regulation of OPN expression in vitro, w
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