Добірка наукової літератури з теми "Biliary secretion"

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Статті в журналах з теми "Biliary secretion"

1

Blot-Chabaud, M., M. Dumont, M. Corbic, and S. Erlinger. "Effect of acid-base balance on biliary bicarbonate secretion in the isolated perfused guinea pig liver." American Journal of Physiology-Gastrointestinal and Liver Physiology 258, no. 6 (1990): G863—G872. http://dx.doi.org/10.1152/ajpgi.1990.258.6.g863.

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Анотація:
Secretin-induced choleresis is of ductal origin and involves bicarbonate transport. Its mechanism is unknown. To determine the relative effects of systemic pH, PCO2, and bicarbonate concentration on secretin-stimulated bicarbonate transport, states of acute metabolic and respiratory acidosis or alkalosis were created in isolated perfused guinea pig livers with or without secretin infusion. During spontaneous secretion conditions, biliary bicarbonate secretion was not correlated with perfusate pH (7.19-7.62) or perfusate PCO2 (23.9-59.7) but was significantly correlated with perfusate bicarbona
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2

Uc, Aliye, Radhamma Giriyappa, David K. Meyerholz, et al. "Pancreatic and biliary secretion are both altered in cystic fibrosis pigs." American Journal of Physiology-Gastrointestinal and Liver Physiology 303, no. 8 (2012): G961—G968. http://dx.doi.org/10.1152/ajpgi.00030.2012.

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The pancreas, liver, and gallbladder are commonly involved in cystic fibrosis (CF), and acidic, dehydrated, and protein-rich secretions are characteristic findings. Pancreatic function studies in humans have been done by sampling the jejunal fluid. However, it has been difficult to separately study the function of pancreatic and biliary systems in humans with CF, because jejunal fluid contains a mixture of bile and pancreatic fluids. In contrast, pancreatic and biliary ducts open separately into the porcine intestine; therefore, biliary and pancreatic fluid can be individually analyzed in CF p
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3

Sætre, S. S., N. J. Andersen, T. Houe, et al. "Regulation of porcine biliary secretion by secretin." Acta Physiologica Scandinavica 163, no. 1 (1998): 113–19. http://dx.doi.org/10.1046/j.1365-201x.1998.00349.x.

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4

Alpini, G., R. Lenzi, W. R. Zhai, et al. "Bile secretory function of intrahepatic biliary epithelium in the rat." American Journal of Physiology-Gastrointestinal and Liver Physiology 257, no. 1 (1989): G124—G133. http://dx.doi.org/10.1152/ajpgi.1989.257.1.g124.

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Анотація:
To shed light on ductular fluid secretion, hepatic histology and ultrastructure, cell proliferation and phenotypes, and several aspects of biliary physiology were studied in rats with ductular cell hyperplasia induced by either biliary obstruction (0-14 days) or 1-naphthylisothiocyanate (ANIT) feeding (0-28 days). In both groups of experimental animals, bile duct hyperplasia and spontaneous bile flow and secretin-induced choleresis increased with time of treatment in a linear fashion. Measurements of [14C]mannitol biliary entry and of biliary tree volume showed that the increase in both sponta
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5

Zeniya, M., and A. Reuben. "Triton WR-1339-induced changes in serum lipids and biliary lipid secretion." American Journal of Physiology-Gastrointestinal and Liver Physiology 254, no. 3 (1988): G346—G354. http://dx.doi.org/10.1152/ajpgi.1988.254.3.g346.

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Анотація:
Biliary lipid secretion rates were measured in fed rats after an intravenous injection of Triton WR-1339 (TWR, 60 mg/100 g body wt), an agent that inhibits lipoprotein removal from the circulation. Serum triglyceride, phospholipid (PL), and cholesterol (CH) concentrations rose within 3 h of TWR to 45, 6.6, and 10 times control values, respectively, at 24-36 h. Serum lipids fell rapidly at 48 h and were normal by 72-96 h after TWR. TWR did not alter bile flow, hepatic bile acid transport, or biliary bile acid output. Within 0.5 h of TWR, biliary PL and CH outputs fell greater than 70%, and taur
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6

Hofmann, Alan F. "Biliary Secretion: Future Perspectives." Digestion 58, no. 1 (1997): 24–28. http://dx.doi.org/10.1159/000201519.

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7

Reuben, A., P. N. Maton, G. M. Murphy, and R. H. Dowling. "Bile Lipid Secretion in Obese and Non-Obese Individuals with and without Gallstones." Clinical Science 69, no. 1 (1985): 71–79. http://dx.doi.org/10.1042/cs0690071.

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Анотація:
1. Biliary lipid secretion rates were measured in non-obese and obese individuals with and without cholesterol gallstones, using a steady-state, amino acid duodenal perfusion method. In addition, biliary lipid secretion rates were measured in five obese gallstone patients receiving high-dose chenodeoxycholic acid therapy (16-22 mg day−1 kg−1). 2. Bile acid secretion rates in the non-obese patients with cholesterol gallstones (563+sem 70 μmol/h, n = 6) were significantly lower than in the non-obese controls (1078 + 210 μmol/h, n = 10, P < 0.05), whereas cholesterol secretion rates were simil
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8

Chanussot, F., H. Lafont, J. Hauton, B. Tuchweber, and I. Yousef. "Studies on the origin of biliary phospholipid. Effect of dehydrocholic acid and cholic acid infusions on hepatic and biliary phospholipids." Biochemical Journal 270, no. 3 (1990): 691–95. http://dx.doi.org/10.1042/bj2700691.

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Анотація:
The correlation between the secretion of biliary phospholipid (PL) and bile acid suggests a regulatory effect of bile acid on PL secretion. Bile acids may influence PL synthesis and/or the mobilization of a preformed PL pool. The objective of this study was to determine the contribution of these two sources to biliary PL, by using an experimental protocol in which dehydrocholic acid (DHCA) and cholic acid (CA) were infused to manipulate biliary PL secretion. In control rats, there was a steady state in bile flow. PL secretion and the biliary secretion of newly synthesized phosphatidylcholine (
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9

Han, Yuyan, Paolo Onori, Fanyin Meng, et al. "Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis." American Journal of Physiology-Gastrointestinal and Liver Physiology 307, no. 9 (2014): G894—G904. http://dx.doi.org/10.1152/ajpgi.00288.2014.

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Biliary hyperplasia and liver fibrosis are common features in cholestatic liver disease. Melatonin is synthesized by the pineal gland as well as the liver. Melatonin inhibits biliary hyperplasia of bile duct-ligated (BDL) rats. Since melatonin synthesis (by the enzyme serotonin N-acetyltransferase, AANAT) from the pineal gland increases after dark exposure, we hypothesized that biliary hyperplasia and liver fibrosis are diminished by continuous darkness via increased melatonin synthesis from the pineal gland. Normal or BDL rats (immediately after surgery) were housed with light-dark cycles or
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10

Verkade, H. J., R. Havinga, A. Gerding, R. J. Vonk, and F. Kuipers. "Mechanism of bile acid-induced biliary lipid secretion in the rat: effect of conjugated bilirubin." American Journal of Physiology-Gastrointestinal and Liver Physiology 264, no. 3 (1993): G462—G469. http://dx.doi.org/10.1152/ajpgi.1993.264.3.g462.

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Анотація:
We have compared the effects of bilirubin and bilirubin ditaurate (BDT) on biliary phospholipid and cholesterol secretion in unanesthetized normal Wistar (NW) and Groningen Yellow (GY) Wistar rats under various experimental conditions. GY rats express a genetic defect in biliary secretion, but not in hepatic uptake, of various organic anions. Under physiological conditions, NW and GY rats showed similar biliary secretion rates of bile acids and of bilirubin, despite the fact that bilirubin concentrations in GY plasma were 25 times as high and in GY livers three times as high as in NW plasma an
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