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Готові списки джерел за темами / Biomedical device-related infection / Статті в журналах

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Статті в журналах з теми "Biomedical device-related infection"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Cook, Guy S. "PATHOGENESIS OF DEVICE RELATED INFECTION." ASAIO Journal 48, no. 2 (2002): 191. http://dx.doi.org/10.1097/00002480-200203000-00260.

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2

Costerton, J. W., A. E. Khoury, K. H. Ward, and H. Anwar. "Practical Measures to Control Device-Related Bacterial Infections." International Journal of Artificial Organs 16, no. 11 (1993): 765–70. http://dx.doi.org/10.1177/039139889301601104.

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Direct examination of medical devices that have been foci of chronic device-related bacterial infections has shown that the causative organisms grow predominantly in slime-enclosed biofilms. These adherent biofilms are inherently resistant to host defences (antibodies, phagocytes) and to conventional antibiotic therapy. Device-related infections can be prevented by careful cleaning and sterilization of the device, and by the avoidance of any manipulations that would allow the formation of even the most rudimentary biofilm prior to implantation. Once a device-related infection has become establ

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3

Mack, D., H. Rohde, L. G. Harris, A. P. Davies, M. A. Horstkotte, and J. K. M. Knobloch. "Biofilm Formation in Medical Device-Related Infection." International Journal of Artificial Organs 29, no. 4 (2006): 343–59. http://dx.doi.org/10.1177/039139880602900404.

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4

Holman, W. L. "Microbiology of Infection in Mechanical Circulatory Support." International Journal of Artificial Organs 30, no. 9 (2007): 764–70. http://dx.doi.org/10.1177/039139880703000904.

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The results of MCSS therapy for patients with severe heart failure are improving, and there are increasing numbers of implants as device therapy enters the era of permanent use (i.e., destination therapy). Device-related infection of implanted pumps and sepsis remain important risk factors for death, and once infections are established on biomaterial surfaces they usually persist despite prolonged antimicrobial therapy. This paper covers the topic of infection in mechanical circulatory support. Methods to prevent and manage infection are described. Recent information from the field of microbio

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5

&NA;. "COLONIZATION AND DEVICE-RELATED INFECTION IN LVAD RECIPIENTS." ASAIO Journal 44, no. 2 (1998): 34A. http://dx.doi.org/10.1097/00002480-199803000-00124.

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6

Darouiche, R. O. "Antimicrobial Coating of Devices for Prevention of Infection: Principles and Protection." International Journal of Artificial Organs 30, no. 9 (2007): 820–27. http://dx.doi.org/10.1177/039139880703000912.

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Device-associated infections are responsible for about half of nosocomial infections and can cause major medical and economical sequelae. Despite adherence to basic infection control measures, which constitute the mainstay for preventing infection, infections associated with certain devices continue to exist at unacceptably high rates. Potentially-preventive, antimicrobial-utilizing strategies include systemic antibiotic prophylaxis and local administration of antimicrobial agents (antibiotics or antiseptics), which includes antimicrobial irrigation of the surgical field, placement of antimicr

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7

Ushijima, Tomoki, Yoshihisa Tanoue, Hirofumi Onitsuka, Atsuhiro Nakashima, and Ryuji Tominaga. "Operative modification for the prevention of device-related infection during NIPRO extracorporeal left ventricular assist device implantation." Journal of Artificial Organs 17, no. 3 (2014): 220–27. http://dx.doi.org/10.1007/s10047-014-0766-0.

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8

Pusparajah, Priyia, Vengadesh Letchumanan, Jodi Woan-Fei Law, et al. "Streptomyces sp.—A Treasure Trove of Weapons to Combat Methicillin-Resistant Staphylococcus aureus Biofilm Associated with Biomedical Devices." International Journal of Molecular Sciences 22, no. 17 (2021): 9360. http://dx.doi.org/10.3390/ijms22179360.

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Biofilms formed by methicillin-resistant S. aureus (MRSA) are among the most frequent causes of biomedical device-related infection, which are difficult to treat and are often persistent and recurrent. Thus, new and effective antibiofilm agents are urgently needed. In this article, we review the most relevant literature of the recent years reporting on promising anti-MRSA biofilm agents derived from the genus Streptomyces bacteria, and discuss the potential contribution of these newly reported antibiofilm compounds to the current strategies in preventing biofilm formation and eradicating pre-e

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9

Von Eiff, C., and K. Becker. "Small-colony Variants (SCVs) of Staphylococci: A Role in Foreign Body-associated Infections." International Journal of Artificial Organs 30, no. 9 (2007): 778–85. http://dx.doi.org/10.1177/039139880703000906.

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Staphylococci have various strategies for resisting therapy that extend beyond classic mechanisms. Clinical experience with device-associated infections as well as with infections due to small-colony variants (SCVs) clearly shows that both antibacterial chemotherapy and host defense mechanisms are often unable to eliminate the pathogens and cure these infections. Of particular interest is the fact that in the past few years an increasing number of various foreign body-related infections due to staphylococcal SCVs have been reported. In this overview, the characteristics of SCVs recovered from

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10

Del Pozo, Jose L. "Role of Antibiotic Lock Therapy for the Treatment of Catheter-Related Bloodstream Infections." International Journal of Artificial Organs 32, no. 9 (2009): 678–88. http://dx.doi.org/10.1177/039139880903200918.

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Catheter-related bloodstream infections are often difficult to treat because they are caused by organisms that embed themselves in a bio film layer on the catheter surface, resulting in an increased resistance to antimicrobial agents. Systemic antibiotics are usually administered but, although generally effective in eliminating circulating bacteria, they frequently fail to sterilize the line, leaving the patient at a continuing risk of complications or recurrence. A successful approach to managing these infections requires making an appropriate decision regarding whether the catheter should be

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11

Hawthorn, Alexandra, Andrew C. Bulmer, Sapha Mosawy, and Samantha Keogh. "Implications for maintaining vascular access device patency and performance: Application of science to practice." Journal of Vascular Access 20, no. 5 (2019): 461–70. http://dx.doi.org/10.1177/1129729818820200.

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Introduction:Vascular access devices are commonly inserted devices that facilitate the administration of fluids and drugs, as well as blood sampling. Despite their common use in clinical settings, these devices are prone to occlusion and failure, requiring replacement and exposing the patient to ongoing discomfort/pain, local vessel inflammation and risk of infection. A range of insertion and maintenance strategies are employed to optimize device performance; however, the evidence base for many of these mechanisms is limited and the mechanisms contributing to the failure of these devices are l

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12

Higgins, Nathan, John Gardner, Anna Wexler, Philipp Kellmeyer, Kerry O'Brien, and Adrian Carter. "Post-trial access to implantable neural devices: an exploratory international survey." BMJ Surgery, Interventions, & Health Technologies 6, no. 1 (2024): e000262. http://dx.doi.org/10.1136/bmjsit-2024-000262.

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ObjectivesClinical trials of innovative neural implants are rapidly increasing and diversifying, but little is known about participants’ post-trial access to the device and ongoing clinical care. This exploratory study examines common practices in the planning and coordination of post-trial access to neurosurgical devices. We also explore the perspectives of trial investigators on the barriers to post-trial access and ongoing care, as well as ethical questions related to the responsibilities of key stakeholder groups.Design, setting, and participantsTrial investigators (n=66) completed a surve

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13

Schurr, James W., Frank C. Seifert, and Allison J. McLarty. "Long-term discontinuation of antithrombotic therapy in patients with HeartMate II continuous-flow left ventricular assist device support." International Journal of Artificial Organs 42, no. 12 (2019): 770–74. http://dx.doi.org/10.1177/0391398819861976.

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Recurrent bleeding events are a common complication of left ventricular assist devices leading to significant morbidity. Clinicians may be reluctant to discontinue all antithrombotic therapies in this setting because of the risk of thrombotic events. To evaluate the safety of this strategy, we conducted a retrospective review of patients within our institution’s left ventricular assist device program from February 2010 to July 2018 who had all antithrombotic therapies discontinued in response to recurrent bleeding events requiring hospitalization. Thrombotic and bleeding outcomes after discont

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14

Costerton, J. W., L. Montanaro, and C. R. Arciola. "Biofilm in Implant Infections: Its Production and Regulation." International Journal of Artificial Organs 28, no. 11 (2005): 1062–68. http://dx.doi.org/10.1177/039139880502801103.

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A significant proportion of medical implants become the focus of a device-related infection, difficult to eradicate because bacteria that cause these infections live in well-developed biofilms. Biofilm is a microbial derived sessile community characterized by cells that are irreversibly attached to a substratum or interface to each other, embedded in a matrix of extracellular polymeric substances that they have produced. Bacterial adherence and biofilm production proceed in two steps: first, an attachment to a surface and, second, a cell-to-cell adhesion, with pluristratification of bacteria o

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15

Ammann, CExperimental Orthopaedics Innsbruck Medical University Innsbruck Austriahristoph G., Manfred Fille, Johann Hausdorfer, Michael Nogler, Markus Nagl, and Débora Coraça-Huber. "Influence of poly-N-acetylglucosamine in the extracellular matrix on N-chlorotaurine mediated killing of Staphylococcus epidermidis." New Microbiologica 37 (December 12, 2017): 361–64. https://doi.org/10.5281/zenodo.1110704.

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N–chlorotaurine (NCT) has recently been shown to have bactericidal activity against bacterial biofilm on metal discs (Coraca-Huber et al., 2014). In a biofilm, Staphylococcus epidermidis polymerizes poly-N-acetylglucosamine (PNAG) to form an extracellular matrix (ECM). Pseudomonas aeruginosa does not express this PNAG and has been shown to be highly susceptible to NCT. We compared the action of NCT on S. epidermidis 1457, a PNAG positive strain (SE1457) and S. epidermidis 1457- M10 an isogenic PNAG negative mutant (SE1457 M10). NCT-mediated killing was more effective and quicker on the P

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16

Song, Bing, Rui Gao, Xiaohui Xu, and Weijun Yan. "Coptisine Down-Regulates Soluble Intercellular Adhesion Molecule-1 by Inactivating Fas/FasL Signaling Pathway to Inhibit the Recurrence After Orthodontics." Journal of Biomedical Nanotechnology 19, no. 12 (2023): 2204–9. http://dx.doi.org/10.1166/jbn.2023.3718.

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In this study, by constructing a rat model of orthodontic recurrence and intervening with coptisine, the IL-6, IL-8, TNF-α and soluble intercellular adhesion molecule-1 (sICAM-1) content were analyzed to assess the regulatory mechanism of coptisine on the health status of recurrent periodontal tissue after orthodontics and the occurrence of periodontal tissue inflammation. Male rats were assigned into three groups by constructing coptisine liposome nano-objects: blank group (Blank, 10 rats), orthodontic tooth movement model group (50 rats). The orthodontic tooth movement model group was random

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17

Cosentino, Felice, Emanuele Tumino, Giovanni Rubis Passoni, Elisabetta Morandi, and Alfonso Capria. "Functional Evaluation of the Endotics System, a New Disposable Self-Propelled Robotic Colonoscope: in vitro tests and clinical trial." International Journal of Artificial Organs 32, no. 8 (2009): 517–27. http://dx.doi.org/10.1177/039139880903200806.

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Objective Currently, the best method for CRC screening is colonoscopy, which ideally (where possible) is performed under partial or deep sedation. This study aims to evaluate the efficacy of the Endotics System, a new robotic device composed of a workstation and a disposable probe, in performing accurate and well-tolerated colonoscopies. This new system could also be considered a precursor of other innovating vectors for atraumatic locomotion through natural orifices such as the bowel. The flexible probe adapts its shape to the complex contours of the colon, thereby exerting low strenuous forc

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18

Vinh, Donald C., and John M. Embil. "Device-Related Infections: A Review." Journal of Long-Term Effects of Medical Implants 15, no. 5 (2005): 467–88. http://dx.doi.org/10.1615/jlongtermeffmedimplants.v15.i5.20.

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19

Matthew, Ugochukwu Okwudili, Andrew Chinonso Nwanakwaugwu, Jazuli S. Kazaure, et al. "Ultra Violet (UV) Light Irradiation Device for Hospital Disinfection." International Journal of Information Communication Technologies and Human Development 14, no. 1 (2022): 1–24. http://dx.doi.org/10.4018/ijicthd.313978.

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The biomedical technology application of ultraviolet light device was reviewed in the current research in a manner to improve public healthcare safety. The research adopted ultraviolet light irradiation to enable elimination of hospital acquired infections caused by bacteria, viruses, and other pathogens within the healthcare facilities. The paper reviewed 12 related biomedical literature that discussed the topic of hospital disinfection using ultraviolet device technology. The paper observed that installation of autonomous internet of things 5G medical disinfecting device for continuous steri

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20

Thet, Naing T., Laura Wallace, Anne Wibaux, Nick Boote, and A. Toby A. Jenkins. "Development of a mixed‐species biofilm model and its virulence implications in device related infections." Journal of Biomedical Materials Research Part B: Applied Biomaterials 107, no. 1 (2018): 129–37. http://dx.doi.org/10.1002/jbm.b.34103.

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21

Kiran, M. D., A. Giacometti, O. Cirioni, and N. Balaban. "Suppression of Biofilm Related, Device-Associated Infections by Staphylococcal Quorum Sensing Inhibitors." International Journal of Artificial Organs 31, no. 9 (2008): 761–70. http://dx.doi.org/10.1177/039139880803100903.

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22

Del Pozo, J. L., M. Alonso, C. R. Arciola, et al. "Biotechnological War against Biofilms. Could Phages Mean the End of Device-Related Infections?" International Journal of Artificial Organs 30, no. 9 (2007): 805–12. http://dx.doi.org/10.1177/039139880703000910.

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Microorganisms universally attach to surfaces, resulting in biofilm formation. These biofilms entail a serious problem in daily clinical practice because of the great prevalence of implantable device-related infections. Differences in antibiotic activity against planktonic and sessile bacteria may relate to clinical failures in the treatment of biofilm-related infections (BRI). Bacteriophages have several characteristics that make them potentially attractive therapeutic agents in some selected clinical settings, like for example BRI. They are highly specific and very effective in lysing target

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23

Devine, Ryan, Priyadarshini Singha, and Hitesh Handa. "Versatile biomimetic medical device surface: hydrophobin coated, nitric oxide-releasing polymer for antimicrobial and hemocompatible applications." Biomaterials Science 7, no. 8 (2019): 3438–49. http://dx.doi.org/10.1039/c9bm00469f.

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In medical device design, there is a vital need for a coating that promotes treatment of the patient and simultaneously prevents fouling by biomacromolecules which in turn can progress to infections, thrombosis and other device-related complications.

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24

Cheng, Qiuli, Yi-Yang Peng, Anika Benozir Asha, et al. "Construction of antibacterial adhesion surfaces based on bioinspired borneol-containing glycopolymers." Biomaterials Science 10, no. 7 (2022): 1787–94. http://dx.doi.org/10.1039/d1bm01949j.

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25

Noble, Misty L., Pierre D. Mourad, and Buddy D. Ratner. "Digital drug delivery: on–off ultrasound controlled antibiotic release from coated matrices with negligible background leaching." Biomater. Sci. 2, no. 6 (2014): 893–902. http://dx.doi.org/10.1039/c3bm60203f.

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26

Agarwalla, Aaruci, Waleed Ahmed, Ali H. Al-Marzouqi, Tahir A. Rizvi, Mushtaq Khan, and Essam Zaneldin. "Characteristics and Key Features of Antimicrobial Materials and Associated Mechanisms for Diverse Applications." Molecules 28, no. 24 (2023): 8041. http://dx.doi.org/10.3390/molecules28248041.

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Since the Fourth Industrial Revolution, three-dimensional (3D) printing has become a game changer in manufacturing, particularly in bioengineering, integrating complex medical devices and tools with high precision, short operation times, and low cost. Antimicrobial materials are a promising alternative for combating the emergence of unforeseen illnesses and device-related infections. Natural antimicrobial materials, surface-treated biomaterials, and biomaterials incorporated with antimicrobial materials are extensively used to develop 3D-printed products. This review discusses the antimicrobia

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27

Morgan, Jeffrey A., YooKyung Park, Mehmet C. Oz, and Yoshifumi Naka. "Device Related Infections While on Left Ventricular Assist Device Support Do Not Adversely Impact Bridging to Transplant or Posttransplant Survival." ASAIO Journal 49, no. 6 (2003): 748–50. http://dx.doi.org/10.1097/01.mat.0000093961.78341.5c.

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28

Stamou, A., E.-D. Venizelou, M. Stavropoulou, N. Fotakopoulou, V. Kapsimali, and G. Vrioni. "Characteristics of biofilms and their formation in biomedical devices." ACTA MICROBIOLOGICA HELLENICA 59, no. 3 (2014): 7–21. https://doi.org/10.5281/zenodo.10017201.

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It is widely acclaimed nowadays that more than 80% of chronic bacterial infections are related to biofilm formation. The biofilm is formed by the accumulation and irreversible adhesion of bacteria to a biological or other surface and a body of extracellular polymeric substance (ESP) or glycocalyx which is excreted by the same microorganisms. Most of their bacteria (99%) are found in adherent form (sessile), whereas a small percentage exists in free, suspended, planktonic form. Being organized in biofilms, bacteria manage to combat the installation of other pathogens in the same focal point, wh

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29

Sinclair, Kristofer D., Theresa X. Pham, Dustin L. Williams, Ryan W. Farnsworth, Catherine M. Loc-Carrillo, and Roy D. Bloebaum. "Model development for determining the efficacy of a combination coating for the prevention of perioperative device related infections: A pilot study." Journal of Biomedical Materials Research Part B: Applied Biomaterials 101, no. 7 (2013): 1143–53. http://dx.doi.org/10.1002/jbm.b.32924.

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30

Chakraborty, Sudip, Georgio Katsifis, Iman Roohani, et al. "Electrostatic and Covalent Binding of an Antibacterial Polymer to Hydroxyapatite for Protection against Escherichia coli Colonization." Materials 16, no. 14 (2023): 5045. http://dx.doi.org/10.3390/ma16145045.

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Orthopedic-device-related infections are notorious for causing physical and psychological trauma to patients suffering from them. Traditional methods of treating these infections have relied heavily on antibiotics and are becoming ineffectual due to the rise of antibiotic-resistant bacteria. Mimics of antimicrobial peptides have emerged as exciting alternatives due to their favorable antibacterial properties and lack of propensity for generating resistant bacteria. In this study, the efficacy of an antibacterial polymer as a coating material for hydroxyapatite and glass surfaces, two materials

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31

Gristina, A. G., G. Giridhar, B. L. Gabriel, P. T. Naylor, and Q. N. Myrvik. "Cell Biology and Molecular Mechanisms in Artificial Device Infections." International Journal of Artificial Organs 16, no. 11 (1993): 755–64. http://dx.doi.org/10.1177/039139889301601103.

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Biomaterials are being used with increasing frequency for tissue substitution. Complex devices such as total joint replacement and the total artificial heart represent combinations of polymers and metal alloys for system and organ replacement. The major barrier to the extended use of these devices is bacterial adhesion to biomaterials, which causes biomaterial-centered infection, and the lack of successful tissue integration or compatibility with biomaterial surfaces. Adhesion-mediated infections are extremely resistant to antibiotics and host defenses and frequently persist until the biomater

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32

Krukiewicz, Katarzyna, Alicja Kazek-Kęsik, Monika Brzychczy-Włoch, et al. "Recent Advances in the Control of Clinically Important Biofilms." International Journal of Molecular Sciences 23, no. 17 (2022): 9526. http://dx.doi.org/10.3390/ijms23179526.

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Biofilms are complex structures formed by bacteria, fungi, or even viruses on biotic and abiotic surfaces, and they can be found in almost any part of the human body. The prevalence of biofilm-associated diseases has increased in recent years, mainly because of the frequent use of indwelling medical devices that create opportunities for clinically important bacteria and fungi to form biofilms either on the device or on the neighboring tissues. As a result of their resistance to antibiotics and host immunity factors, biofilms have been associated with the development or persistence of several c

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33

Hakonen, Bodil, Linnea K. Lönnberg, Eva Larkö, and Kristina Blom. "A Novel Qualitative and Quantitative Biofilm Assay Based on 3D Soft Tissue." International Journal of Biomaterials 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/768136.

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The lack of predictablein vitromethods to analyze antimicrobial activity could play a role in the development of resistance to antibiotics. Current used methods analyze planktonic cells but for the method to be clinically relevant, biofilm inin vivolike conditions ought to be studied. Hence, our group has developed a qualitative and quantitative method within vivolike 3D tissue for prediction of antimicrobial activity in reality. Devices (wound dressings) were applied on top ofPseudomonas aeruginosainoculated Muller-Hinton (MH) agar or 3D synthetic soft tissues (SST) and incubated for 24 hours

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34

Luque-Agudo, Verónica, Daniel Romero-Guzmán, María Fernández-Grajera, M. Luisa González-Martín, and Amparo M. Gallardo-Moreno. "Aging of Solvent-Casting PLA-Mg Hydrophobic Films: Impact on Bacterial Adhesion and Viability." Coatings 9, no. 12 (2019): 814. http://dx.doi.org/10.3390/coatings9120814.

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Анотація:

Biomaterials used for the manufacture of biomedical devices must have suitable surface properties avoiding bacterial colonization and/or proliferation. Most biomaterial-related infections start during the surgery. Bacteria can begin colonization of the surface of a device right after implantation or in the next few hours. This time may also be sufficient to begin the deterioration of a biodegradable implant. This work explores the surface changes that hydrophobic films of poly(lactic) acid reinforced with Mg particles, prepared by solving-casting, undergone after in vitro degradation at differ

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35

Guenther, Sabina PW, Yasuhiro Shudo, William Hiesinger, and Dipanjan Banerjee. "Prolonged veno-arterial extracorporeal life support for cardiac failure." International Journal of Artificial Organs 41, no. 8 (2018): 437–44. http://dx.doi.org/10.1177/0391398818777359.

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Objectives: In intractable cardiogenic shock, extracorporeal life support frequently is the last treatment option. Outcomes of prolonged veno-arterial extracorporeal life support for cardiac failure are poorly defined. Methods: We retrospectively analyzed 10 patients (4 females, age = 36 ± 16 years) who underwent prolonged extracorporeal life support (≥7 days) from December 2015 to March 2017 for cardiogenic shock. The primary endpoint was survival to hospital discharge. Results: Etiologies included ischemic cardiomyopathy with non ST-segment elevation myocardial infarction (n = 1), dilated (n

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36

Brigmon, Matthew M., and Robin L. Brigmon. "Infectious Diseases Impact on Biomedical Devices and Materials." Biomedical Materials & Devices, October 28, 2022. http://dx.doi.org/10.1007/s44174-022-00035-y.

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AbstractInfectious diseases and nosocomial infections may play a significant role in healthcare issues associated with biomedical materials and devices. Many current polymer materials employed are inadequate for resisting microbial growth. The increase in microbial antibiotic resistance is also a factor in problematic biomedical implants. In this work, the difficulty in diagnosing biomedical device-related infections is reviewed and how this leads to an increase in microbial antibiotic resistance. A conceptualization of device-related infection pathogenesis and current and future treatments is

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37

Souza, João Gabriel S., Fabio Azevedo, Maria Helena Rossy Borges, et al. "Microbiome modulation of implant-related infection by a novel miniaturized pulsed electromagnetic field device." npj Biofilms and Microbiomes 11, no. 1 (2025). https://doi.org/10.1038/s41522-025-00667-0.

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Abstract Dental implant-related infections, which lack effective therapeutic strategies, are considered the primary cause for treatment failure. Pulsed electromagnetic field (PEMF) technology has been introduced as a safe and effective modality for enhancing biological responses. However, the PEMF effect on modulating microbial diversity has not been explored. Thus, we tested a miniaturized PEMF biomedical device as a healing component for dental implants. PEMF activation did not alter the chemical composition, surface roughness, wettability, and electrochemical performance. PEMF effectively c

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Kervan, Umit, Yasemin Tezer, Sinan Sabit Kocabeyoglu, et al. "Does minimally invasive approach reduce risk of infection after ventricular assist device implantation?" International Journal of Artificial Organs, May 10, 2021, 039139882110133. http://dx.doi.org/10.1177/03913988211013367.

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Background: We analyzed patients with left ventricular assist device (LVAD) related and specific infection, and aimed to determine whether surgical technique implantation affect the frequency of infection. Methods: We retrospectively analyzed the data of 99 patients who received LVAD at our department between June 2013 and June 2019. Patients were divided into two groups according to the surgical technique. Group A ( n = 58) was conventional sternotomy (CS) and group B ( n = 41) was on-pump minimally invasive left thoracotomy (MILT). Demographics, preoperative risk factors, LVAD infections, su

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Muljadi, Michael, Chao-Min Cheng, Chung-Yao Yang, Ting-Chang Chang, and Ching-Ju Shen. "A pilot clinical validation study of a self-collected vaginal swab device for the detection of chlamydia trachomatis in women." Frontiers in Bioengineering and Biotechnology 10 (October 4, 2022). http://dx.doi.org/10.3389/fbioe.2022.1008761.

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Chlamydia trachomatis (C. trachomatis) is one of the most prevalent preventable sexually transmitted diseases (STDs) in the world. In women, C. trachomatis infection can lead to long-term complications such as pelvic inflammatory disease (PID), and other related conditions such as ectopic pregnancies and even tubal factor infertility. These complications are preventable given early detection and clinical intervention, but these efforts are often hampered by asymptomatic silent infections, and non-compliance to screenings for STDs. Some women do not get tested out of concerns for violation of p

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Topaz, Moris, Itamar Ashkenazi, Oren Barzel, et al. "Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: a retrospective study." Burns & Trauma 9 (January 1, 2021). http://dx.doi.org/10.1093/burnst/tkab007.

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Abstract Background Following combat-related, extensive soft tissue injury from gunshot wounds or blasts, prolonged duration from injury to full wound closure is associated with infection, increased morbidity and mortality, failure to mobilize, poor functional outcome and increased cost. The purpose of this study was to evaluate a novel treatment enabling early primary closure of combat wounds. Methods This was a retrospective study of 10 soldiers and civilians with extensive combat-related soft tissue limb injuries (5 gunshot wounds, 5 blasts) treated using the TopClosure® Tension Relief Syst

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Kassi, Mahwash, Eleonora Avenatti, Khanh‐Doan Hoang, et al. "Repeat left ventricular‐assisted device exchange and upgrade from second‐ to third‐generation devices in a high‐volume single center." Artificial Organs, January 8, 2024. http://dx.doi.org/10.1111/aor.14710.

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AbstractBackgroundPump exchange is an established strategy to treat LVAD‐related complications such as thrombosis, infection, and driveline failure. Pump upgrades with an exchange to newer generation devices are being performed to the advantage of the patient on long‐term support. The safety and efficacy of a repeat LVAD exchange with a concomitant upgrade to a third‐generation pump have not been reported.MethodsWe performed a retrospective analysis of all consecutive patients who underwent a repeat LVAD device exchange and upgrade to HeartMate III (HMIII) at Houston Methodist Hospital between

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Khursheed, Asma, Li‐Chong Xu, and Christopher A. Siedlecki. "The effects of submicron‐textured surface topography on antibiotic efficacy against biofilms." Journal of Biomedical Materials Research Part B: Applied Biomaterials 112, no. 7 (2024). http://dx.doi.org/10.1002/jbm.b.35436.

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AbstractSubmicron‐textured surfaces have been a promising approach to mitigate biofilm development and control microbial infection. However, the use of the single surface texturing approach is still far from ideal for achieving complete control of microbial infections on implanted biomedical devices. The use of a surface topographic modification that might improve the utility of standard antibiotic therapy could alleviate the complications of biofilms on devices. In this study, we characterized the biofilms of Staphylococcus aureus and Pseudomonas aeruginosa on smooth and submicron‐textured po

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Wang, Yue, Bingyue Cai, Dalong Ni, Yu Sun, Gang Wang, and Hong Jiang. "A novel antibacterial and antifouling nanocomposite coated endotracheal tube to prevent ventilator-associated pneumonia." Journal of Nanobiotechnology 20, no. 1 (2022). http://dx.doi.org/10.1186/s12951-022-01323-x.

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Abstract Background The endotracheal tube (ETT) is an essential medical device to secure the airway patency in patients undergoing mechanical ventilation or general anesthesia. However, long-term intubation eventually leads to complete occlusion, ETTs potentiate biofilm-related infections, such as ventilator-associated pneumonia. ETTs are mainly composed of medical polyvinyl chloride (PVC), which adheres to microorganisms to form biofilms. Thus, a simple and efficient method was developed to fabricate CS-AgNPs@PAAm-Gelatin nanocomposite coating to achieve dual antibacterial and antifouling eff

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Wang, Kun, Qihang Ding, Manlin Qi, et al. "Integrated Bilayer Microneedle Dressing and Triboelectric Nanogenerator for Intelligent Management of Infected Wounds." Advanced Functional Materials, February 7, 2024. http://dx.doi.org/10.1002/adfm.202316820.

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AbstractThe integration of real‐time monitoring and on‐demand treatment has substantial potential to accelerate wound healing processes. In this context, versatile bilayer microneedles (MNs) and a triboelectric nanogenerator (TENG) are developed as a theranostic platform for efficient wound management. This platform provides benefits including controlling infection, promoting cell migration and proliferation, and the capability for biochemical sensing. The bilayer MNs comprise a solvable polyvinylpyrrolidone MN (pMN) affixed atop a conductive stainless‐steel MN (sMN). The robust sMN penetrates

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Shunmugaperumal, Tamilvanan. "The Role of Biofilms in Device-Related Infections." Journal of Medical Devices 5, no. 1 (2011). http://dx.doi.org/10.1115/1.4003637.

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"Predicting the Fasting Plasma Glucose Level Using Two Linear Regression Equations from Body Temperature and Weight in the Early Morning as Inputs over a 14-Month Period for a type 2 Diabetes Patient Based on GH-Method: Math-Physical Medicine (No. 558)." Journal of Applied Material Science & Engineering Research 5, no. 4 (2021). http://dx.doi.org/10.33140/jamser.05.04.04.

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The author is a 27-year type 2 diabetes (T2D) patient, who has self-studied and researched diabetes, endocrinology, and chronic disease induced complications since 2010. He is a mathematician and engineer but not a medical doctor; therefore, he does his best to derive some mathematical equations or formulas with sufficient accuracy to describe the observed biomedical or biophysical phenomena. His medical research work started with the task of collecting big data on his own biomarker values and lifestyle details. To date, he has collected and processed nearly 3 million data related to his healt

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Kennedy, James P., Richard A. Lasher, Donald Solomon, and Robert W. Hitchcock. "Disinfection of Male Luer Style Connectors for Prevention of Catheter Related Bloodstream Infections Using an Isopropyl Alcohol Dispensing Cap." Journal of Medical Devices 4, no. 2 (2010). http://dx.doi.org/10.1115/1.3442645.

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Bacterial colonization of needleless injection sites (NISs) frequently results in catheter related bloodstream infections (CRBSIs). Hospitals have instituted protocols aimed at disinfecting NIS prior to access. Furthermore, several manufactures have developed devices that facilitate disinfection of NIS. Despite these steps, the incidence of CRBSI is still alarmingly high. Currently, there is no protocol or device intended to disinfect male luer connectors such as those found on IV tubing that are commonly coupled and decoupled from the NISs. Since these IV tubing connectors directly contact th

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McDonald, Robert C. "Development of a pO2-Guided Fine Needle Tumor Biopsy Device." Journal of Medical Devices 16, no. 2 (2022). http://dx.doi.org/10.1115/1.4052900.

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Abstract Tumor biopsies are an important aspect of oncology providing a guide for medical treatment and evaluation of disease progression. Highly heterogenous tumors have complex regions of active cancer cells interdigitated with necrotic tissue and healthy noncancerous tissue. The reliable access to tumor tissue pathology is therefore challenging and usually requires multiple needle insertions with accompanying patient discomfort and risk of infection. Oxygen levels provide a means of detecting and evaluating tumor tissue with levels reduced by 2-fold to 22-fold, depending on the type of orga

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Ghezzi, Daniele, Marco Boi, Enrico Sassoni, et al. "Customized biofilm device for antibiofilm and antibacterial screening of newly developed nanostructured silver and zinc coatings." Journal of Biological Engineering 17, no. 1 (2023). http://dx.doi.org/10.1186/s13036-023-00326-y.

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Abstract Background Bacterial colonisation on implantable device surfaces is estimated to cause more than half of healthcare-associated infections. The application of inorganic coatings onto implantable devices limits/prevents microbial contaminations. However, reliable and high-throughput deposition technologies and experimental trials of metal coatings for biomedical applications are missing. Here, we propose the combination of the Ionized Jet Deposition (IJD) technology for metal-coating application, with the Calgary Biofilm Device (CBD) for high-throughput antibacterial and antibiofilm scr

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Arpaçay, Pınar, and Uğur Türkan. "Development of antibiotic-loaded silk fibroin/hyaluronic acid polyelectrolyte film coated CoCrMo alloy." Biomedical Engineering / Biomedizinische Technik 61, no. 5 (2016). http://dx.doi.org/10.1515/bmt-2015-0061.

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AbstractBacteria related infections are still a major problem for the implant materials. Such infections have occurred in nearly 3% of hip and knee replacements resulting in failure of device. There are two main approaches for inhibiting the bacterial adhesion to the surface. These involve bactericidal substances and anti-adhesive coatings. In this study, the efficiency of antibiotic-loaded silk fibroin/hyaluronic acid polyelectrolyte film coated CoCrMo alloy, prepared by means of complex coacervate and layer by layer techniques, was investigated. A medical grade CoCrMo was coated with variabl

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