Готові списки джерел за темами / Blood-brain barrier Physiology

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Добірка наукової літератури з теми "Blood-brain barrier Physiology"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 3 лютого 2022

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Статті в журналах з теми "Blood-brain barrier Physiology"

1

Dunn, Jeff F., and Albert M. Isaacs. "The impact of hypoxia on blood-brain, blood-CSF, and CSF-brain barriers." Journal of Applied Physiology 131, no. 3 (September 1, 2021): 977–85. http://dx.doi.org/10.1152/japplphysiol.00108.2020.

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Анотація:
The blood-brain barrier (BBB), blood-cerebrospinal fluid (CSF) barrier (BCSFB), and CSF-brain barriers (CSFBB) are highly regulated barriers in the central nervous system comprising complex multicellular structures that separate nerves and glia from blood and CSF, respectively. Barrier damage has been implicated in the pathophysiology of diverse hypoxia-related neurological conditions, including stroke, multiple sclerosis, hydrocephalus, and high-altitude cerebral edema. Much is known about the damage to the BBB in response to hypoxia, but much less is known about the BCSFB and CSFBB. Yet, it
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2

Koziara, J. M., P. R. Lockman, D. D. Allen, and R. J. Mumper. "The Blood-Brain Barrier and Brain Drug Delivery." Journal of Nanoscience and Nanotechnology 6, no. 9 (September 1, 2006): 2712–35. http://dx.doi.org/10.1166/jnn.2006.441.

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The present report encompasses a thorough review of drug delivery to the brain with a particular focus on using drug carriers such as liposomes and nanoparticles. Challenges in brain drug delivery arise from the presence of one of the strictest barriers in vivo—the blood-brain barrier (BBB). This barrier exists at the level of endothelial cells of brain vasculature and its role is to maintain brain homeostasis. To better understand the principles of brain drug delivery, relevant knowledge of the blood-brain barrier anatomy and physiology is briefly reviewed. Several approaches to overcome the
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3

McCaffrey, Gwen, and Thomas P. Davis. "Physiology and Pathophysiology of the Blood-Brain Barrier." Journal of Investigative Medicine 60, no. 8 (December 1, 2012): 1131–40. http://dx.doi.org/10.2310/jim.0b013e318276de79.

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4

Serlin, Yonatan, Ilan Shelef, Boris Knyazer, and Alon Friedman. "Anatomy and physiology of the blood–brain barrier." Seminars in Cell & Developmental Biology 38 (February 2015): 2–6. http://dx.doi.org/10.1016/j.semcdb.2015.01.002.

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5

Robinson, P. J. "MEASUREMENT OF BLOOD-BRAIN BARRIER PERMEABILITY." Clinical and Experimental Pharmacology and Physiology 17, no. 12 (December 1990): 829–40. http://dx.doi.org/10.1111/j.1440-1681.1990.tb01286.x.

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6

Tietz, Silvia, and Britta Engelhardt. "Brain barriers: Crosstalk between complex tight junctions and adherens junctions." Journal of Cell Biology 209, no. 4 (May 25, 2015): 493–506. http://dx.doi.org/10.1083/jcb.201412147.

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Анотація:
Unique intercellular junctional complexes between the central nervous system (CNS) microvascular endothelial cells and the choroid plexus epithelial cells form the endothelial blood–brain barrier (BBB) and the epithelial blood–cerebrospinal fluid barrier (BCSFB), respectively. These barriers inhibit paracellular diffusion, thereby protecting the CNS from fluctuations in the blood. Studies of brain barrier integrity during development, normal physiology, and disease have focused on BBB and BCSFB tight junctions but not the corresponding endothelial and epithelial adherens junctions. The crossta
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7

Grant, Gerald A., N. Joan Abbott, and Damir Janigro. "Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models." Physiology 13, no. 6 (December 1998): 287–93. http://dx.doi.org/10.1152/physiologyonline.1998.13.6.287.

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Анотація:
Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.
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8

Ermisch, A., P. Brust, R. Kretzschmar, and H. J. Ruhle. "Peptides and blood-brain barrier transport." Physiological Reviews 73, no. 3 (July 1, 1993): 489–527. http://dx.doi.org/10.1152/physrev.1993.73.3.489.

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9

Sweeney, Melanie D., Zhen Zhao, Axel Montagne, Amy R. Nelson, and Berislav V. Zlokovic. "Blood-Brain Barrier: From Physiology to Disease and Back." Physiological Reviews 99, no. 1 (January 1, 2019): 21–78. http://dx.doi.org/10.1152/physrev.00050.2017.

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Анотація:
The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and pathogens from entering the brain. At the same time, the BBB regulates transport of molecules into and out of the central nervous system (CNS), which maintains tightly controlled chemical composition of the neuronal milieu that is required for proper neuronal functioning. In this review, we first examine molecular and cellular mechanisms underlying the establishment of the BBB. Then, we focus on BBB transport physiology, endothelial and pericyte transporters, and perivascular and paravascular transport. Next,
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10

Gray, Sarah M., and Eugene J. Barrett. "Insulin transport into the brain." American Journal of Physiology-Cell Physiology 315, no. 2 (August 1, 2018): C125—C136. http://dx.doi.org/10.1152/ajpcell.00240.2017.

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While there is a growing consensus that insulin has diverse and important regulatory actions on the brain, seemingly important aspects of brain insulin physiology are poorly understood. Examples include: what is the insulin concentration within brain interstitial fluid under normal physiologic conditions; whether insulin is made in the brain and acts locally; does insulin from the circulation cross the blood-brain barrier or the blood-CSF barrier in a fashion that facilitates its signaling in brain; is insulin degraded within the brain; do privileged areas with a “leaky” blood-brain barrier se
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Дисертації з теми "Blood-brain barrier Physiology"

1

Zhu, Chunni. "The Blood-brain barrier in normal and pathological conditions." Title page, abstract and contents only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phz637.pdf.

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Bibliography: leaves 318-367. Examines the blood-brain barrier in normal and pathological conditions induced by intravascular and extravascular insults. Intravascular insults were induced by administration of Clostridium perfringens prototoxin; extravascular insults were induced by an impact acceleration model for closed head injury to induce traumatic brain injury. Also examines the integrity of the blood-brain barrier ultrastructurally and by its ability to exclude endogenous and exogenous tracers. Also studies the expression of 2 blood-brain barrier specific proteins, endothelial barrier a
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2

Corsi, Mariangela. "Ketogenic diet impacts Blood-Brain Barrier physiology : implications for Alzheimers's disease." Thesis, Artois, 2018. http://www.theses.fr/2018ARTO0401.

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Compte tenu de l'absence de traitement pharmacologique efficace contre la maladie d'Alzheimer (MA), le développement d'approches thérapeutiques alternatives telles que le régime cétogène (« ketogenic diet » : KD) pourrait être envisagé. Le KD est un régime riche en graisses, basé sur la production de corps cétoniques (« ketone nodies » : KB) dans le sang. En raison des effets bénéfiques du KD sur le système nerveux central et de l'absence de données publiées sur la barrière hémato-encéphalique (BHE), nous avons utilisé une approche in vivo / in vitro pour étudier l'effet du KD et des KB sur la
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3

Davis, Brandon James. "VEGF signaling mechanisms in increased blood brain barrier permeability following hypoxia." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3261273.

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4

Connell, John J. "Selective permeabilisation of the blood-brain barrier at sites of metastasis." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:8c027208-8ea6-4de4-be78-ccead5121509.

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Over one in five cancer patients will develop brain metastases and prognosis remains poor. Effective chemotherapeutics for primary systemic tumours have limited access to brain metastases owing to the blood-brain barrier (BBB). The aim of this study was to develop a strategy for specifically permeabilising the BBB at sites of cerebral metastases. Tumour necrosis factor was injected intravenously into mouse models of haematogenously induced brain metastasis. BBB permeability was assessed through histology and in vivo MRI and SPECT. Tumour burden and neuroinflammation were assessed after injecti
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5

Hurley, Johannah. "Lipid composition and modulation of transport function in an in vitro model of the blood-brain barrier." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268437.

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6

Africa, Luan Dane. "HIV-1 associated neuroinflammation : effects of two complimentary medicines illustrated in an in vitro model of the blood-brain barrier." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/95869.

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Thesis (MSc)--Stellenbosch University, 2014.<br>ENGLISH ABSTRACT: Background: Neuroinflammation is central to the aetiology of HIV-associated neurocognitive disorders (HAND) that are prevalent in late stage AIDS. ARV treatments are rolled out relatively late in the context of neuroinflammatory changes, so that their usefulness in directly preventing HAND is probably limited. It is common practice for HIV+ individuals in developing countries to make use of traditional/complimentary medicines. One such medicine is Sutherlandia frutescens - commonly consumed as a water infusion. We have also iden
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7

Patel, Ankita Anil. "Examination Of A Post-Stroke Drug Treatment For Its Effect On Blood Brain Barrier Permeability, And Gene Expression Changes In The Peri-Infarct Region." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1472131819.

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8

Felemban, Dalal Nouruldeen. "The Effects of Cold and Freezing Temperatures on The Blood Brain Barrier and Aquaporin 1, 4, and 9 Expression in Cope's Gray Treefrog (Hyla Chrysoscelis)." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1484650973702078.

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9

Nunes, Ana Rita Silva Martins. "O2/CO2-sensitive cyclic AMP-signalling pathway in peripheral chemoreceptors." Doctoral thesis, Faculdade de Ciências Médicas. UNL, 2013. http://hdl.handle.net/10362/9153.

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RESUMO: O corpo carotídeo (CB) é um pequeno órgão sensível a variações na PaO2, PaCO2 e pH. As células tipo I (células glómicas) do corpo carotídeo, as unidades sensoriais deste órgão, libertam neurotransmissores em resposta às variações dos gases arteriais. Estes neurotransmissores atuam quer em recetores pré-sinápticos, localizados nas células tipo I, quer em recetores póssinápticos, localizados nas terminações do nervo do seio carotídeo, ou em ambos. A activação dos recetores pré-sinápticos modula a atividade do corpo carotídeo, enquanto que, a activação dos recetores pós-sinápticos, de
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10

Graham, Cathy D. "Chemosensitive Neurons of the Locus Coeruleus and the Nucleus Tractus Solitarius: Three Dimensional Morphology and Association with the Vasculature." Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1409665728.

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Книги з теми "Blood-brain barrier Physiology"

1

Couraud, Pierre-Olivier, and Daniel Scherman, eds. Biology and Physiology of the Blood-Brain Barrier. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-9489-2.

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2

Bradbury, Michael W. B., ed. Physiology and Pharmacology of the Blood-Brain Barrier. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76894-1.

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3

Davson, Hugh. Physiology of the CSF and blood-brain barriers. Boca Raton: CRC Press, 1996.

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4

V, Zlokovic B., ed. The blood-brain barrier, amino acids, and peptides. Dordrecht: Kluwer Academic Publishers, 1990.

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5

Molecular physiology and metabolism of the nervous system: A clinical perspective. New York: Oxford University Press, 2012.

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6

NATO Advanced Research Workshop on Regulatory Mechanisms of Neuron to Vessel Communication in the Brain. Regulatory mechanisms of neuron to vessel communication in the brain. Berlin: Springer-Verlag, 1989.

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7

Hammarlund-Udenaes, Margareta, Elizabeth C. M. de Lange, and Robert G. Thorne. Drug delivery to the brain: Physiological concepts, methodologies, and approaches. Edited by American Association of Pharmaceutical Scientists. New York: AAPS Press, 2014.

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8

G, De Boer A., ed. Drug tranport(ers) and the diseased brain: Proceedings of the Esteve Foundation Symposium 11, held between 6 and 9 October 2004, S'Agaró (Girona), Spain. Amsterdam, Netherlands: Elsevier, 2005.

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9

C, Porter John, Ježová Daniela, and International Congress of Physiological Sciences (31st : 1989 : Helsinki, Finland), eds. Circulating regulatory factors and neuroendocrine function. New York: Plenum Press, 1990.

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10

Peptide drug delivery to the brain. New York: Raven Press, 1991.

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Частини книг з теми "Blood-brain barrier Physiology"

1

Dehouck, M. P., B. Dehouck, L. Fenart, and R. Cecchelli. "Blood-Brain Barrier in Vitro." In Biology and Physiology of the Blood-Brain Barrier, 143–46. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-9489-2_23.

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2

Gjedde, A. "Blood-Brain Glucose Transfer." In Physiology and Pharmacology of the Blood-Brain Barrier, 65–115. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76894-1_4.

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3

Abbott, N. Joan. "The Bipolar Astrocyte: Polarized Features of Astrocytic Glia Underlying Physiology, with Particular Reference to the Blood-Brain Barrier." In Blood-Brain Barriers, 189–208. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2007. http://dx.doi.org/10.1002/9783527611225.ch8.

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4

Abbott, N. J. "Comparative Physiology of the Blood-Brain Barrier." In Physiology and Pharmacology of the Blood-Brain Barrier, 371–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76894-1_15.

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5

Johansson, Barbro B. "The Physiology of the Blood-Brain Barrier." In Advances in Experimental Medicine and Biology, 25–39. Boston, MA: Springer US, 1990. http://dx.doi.org/10.1007/978-1-4684-5799-5_2.

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6

Begley, D. J. "Peptides and the Blood-Brain Barrier." In Physiology and Pharmacology of the Blood-Brain Barrier, 151–203. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76894-1_6.

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7

Keep, Richard F., Jianming Xiang, and A. Lorris Betz. "The Blood-Brain Barrier, Potassium, and Brain Growth." In Biology and Physiology of the Blood-Brain Barrier, 47–50. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-9489-2_9.

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8

Kam, Peter, Ian Power, Michael J. Cousins, and Philip J. Siddal. "Blood–Brain Barrier and Cerebrospinal Fluid (CSF)." In Principles of Physiology for the Anaesthetist, 35–38. Fourth edition. | Boca Raton : CRC Press, Taylor & Francis Group, 2020.: CRC Press, 2020. http://dx.doi.org/10.1201/9780429288210-5.

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Male, D. K. "Immunology of Brain Endothelium and the Blood-Brain Barrier." In Physiology and Pharmacology of the Blood-Brain Barrier, 397–415. Berlin, Heidelberg: Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76894-1_16.

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Keep, Richard F., Walter Stummer, Jianming Xiang, and A. Lorris Betz. "Blood-Brain Barrier Taurine Transport and Brain Volume Regulation." In Biology and Physiology of the Blood-Brain Barrier, 11–16. Boston, MA: Springer US, 1996. http://dx.doi.org/10.1007/978-1-4757-9489-2_3.

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