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Дисертації з теми "Bones – Diseases"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 30 липня 2024

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1

Cheng, Tak Sum. "Molecular identification and characterization of novel osteoclast V-ATPase subunits." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0068.

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[Truncated abstract] Osteoclasts are multinucleated giant cells responsible for the resorption of the mineralized bone matrix during the process of bone remodelling. During activation towards bone resorption, polarization of the osteoclast results in the formation of a unique plasma membrane, the ruffled border, the actual resorptive organelle of the osteoclast. Through this domain protons are actively pumped into the resorption lacuna creating an acidic microenvironment that favours the dissolution of the mineralized bone matrix. The polarised secretion of protons is carried out by the action

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2

Van, Greunen Francois. "Microcomputer-assisted diagnosis of inherited disorders of the skeleton." Master's thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/25754.

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Several hundred inherited disorders of the skeleton have been delineated. Individually these conditions are rare, but as a group they cause much crippling and hardship. Several factors, including the rarity and complexity of the manifestations of these conditions, as well as semantic overlap, impede the accurate diagnosis which is essential for effective treatment. In this regard, the adoption of microcomputers warrants evaluation as a high technology aid. Microcomputers have developed tremendous capabilities during recent years. The state of the art has become such that a diagnostic aid facil

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3

Foster, Bruce Kristian. "Epiphyseal plate repair using fat interposition to reverse physeal deformity : an experimental study." Title page, contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09MD/09mdf754.pdf.

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Bibliography: leaves 169-197. Hypothesises that the physis has an internal mechanism of repair to restore physeal function. Aims to establish a defined degree of deformity by partial growth plate excision, then to examine different methods of reversal of such deformity to observe the process of growth plate repair. A secondary aim was to define the percentage of physis that could be resected yet still enable reversal of deformity.

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4

Albogami, Mohammed Mater. "Bone loss in osteoporosis and rheumatoid arthritis diseases : the effects of disease mechanisms, age, gender and ethnic origin on responsiveness to treatment." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8901.

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Bone makes up a framework that provides protection for internal body organs. The homeostasis of bone is maintained by a balanced process involving old bone degradation and new bone formation. However, this balance can be altered in pathophysiological conditions such as in postmenopausal osteoporosis and in patients with rheumatoid arthritis (RA). In recent years, new therapies have been developed to reduce bone resorption. However, there is disparity in patients’ response to these therapies. The reasons are unclear although age, gender, ethnic background and lifestyle have all been suggested t

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5

Whitton, Robert Christopher. "Carpal disease in racing horses." Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/26702.

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Thirteen Standardbred horses were trained on a treadmill for 31 weeks as part of a larger study into the effects of overtraining. Synovial fluid was collected from the midcarpal joint at the start, and at seven, 15, 21, 26 and 30 weeks of training. Low grade signs of midcarpal joint disease developed in all horses during the last 16 weeks of the program. Synovial fluid leukocyte counts remained unchanged throughout the study, whereas total protein concentration and lactate dehydrogenase activity increased significantly with training. Sulfated glycosaminoglycan (GAGs) levels increased initially

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6

Karunaratne, Malintha P. Angelo. "Analysis of alterations in matrix quality at nanoscale in metabolic bone diseases using synchrotron X-ray diffraction." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8490.

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Bone diseases such as osteoporosis and rickets cause significant reduction in bone quantity and quality, leading to mechanical abnormalities. While the reduction of bone quantity can be assessed using clinical tools like DXA and pQCT, there is little quantitative knowledge of how altered bone quality in diseased bone increases fracture risk. There is a clear need to develop high-resolution diagnostic techniques to close the gap between onset of fracture relevant changes and diagnosis. Here, a functional imaging technique (in situ synchrotron X-ray imaging with micromechanics) was developed to

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7

Almasabi, Abeer. "Determination of Hydroxyproline in Bone Collagen: Potential Application as a Biomarker for Bone Diseases." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38420.

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Hydroxyproline (Hyp), a non-proteinogenic amino acid is a component of the organic material in bone. It has been used for 14C-dating of bone and the measurement of Hyp could be used as a biomarker in bone metabolism. Hydroxyproline is a component of collagen, the main structural protein in bone. The analyses of 14C in collagen and Hyp in human bones may provide timing information about bone processes and diseases, such as osteoarthritis and osteoporosis. The analysis of Hyp in bones (e.g., the determination of Hyp content) primarily relies on a spectrometric technique, liquid chromatography-ma

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8

Liang, Chao. "Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA Interference-based bone anabolic strategy." HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/325.

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Osteoporosis remain major clinical challenges. RNA interference (RNAi) provides a promising approach for promoting osteoblastic bone formation to settle the challenges. However, the major bottleneck for translating RNAi with efficacy and safety to clinical bone anabolic strategy is lack of osteoblast-specific delivery systems for osteogenic siRNAs. Previously, we developed a targeting system involving DOTAP-based cationic liposomes attached to oligopeptides (AspSerSer)6, (also known as (DSS)6), which had good affinity for bone formation surface. Using this system, osteogenic Pleckstrin Homolog

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9

Vasseleu, Cathryn. "Cleidocranial dysplastic mutant in the mouse : dental findings." Thesis, The University of Sydney, 1986. https://hdl.handle.net/2123/26032.

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Cleidocranial dysplasia is a genetic disorder which affects not only processes of osteogenesis, but also processes of tooth eruption, tooth induction, and craniofacial growth. These last three complications make the condition one which may interest those working in the fields of oral and craniofacial biology. The condition is neither life-threatening nor incapacitating. However, elucidation of the pathological process which it embodies may provide valuable insights into the normal mechanisms of tooth eruption, tooth induction and craniofacial growth, each of which remains a largely unsolved pu

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10

Björnsdóttir, Sigrídur. "Bone spavin in Icelandic horses : aspects of predisposition, pathogenesis and prognosis /." Uppsala : Dept. of Clinical Radiology, Swedish Univ. of Agricultural Sciences ([Institutionen för klinisk radiologi], Sveriges lantbruksuniv, 2002. http://epsilon.slu.se/avh/2002/91-576-6382-3.pdf.

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11

Wang, Cathy Ting-Peng. "Molecular dissection of RANKL signaling pathways in osteoclasts." University of Western Australia. School of Surgery and Pathology, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0037.

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[Truncated abstract] Bone remodeling is intricately regulated by osteoclast-mediated bone resorption and osteoblast-mediated bone formation. The elevation in osteoclast number and/or activity is a major hallmark of several common pathological bone disorders including post-menopausal osteoporosis, osteoarthritis, Paget's disease, and tumour-mediated osteolysis. Receptor activator of nuclear factor kappa B ligand (RANKL) is a key cytokine for osteoclast differentiation and activation. The association of RANKL to its cognate receptor, RANK, which is expressed on osteoclast precursors and mature o

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12

Payne, Scott Andrew. "An Electron Energy-Loss Spectroscopic Investigation of Molecular Interactions at Hydroxyapatite-Collagen Interfaces in Healthy and Diseased (Osteogenesis Imperfecta) Human Bone and Biomineralized Tissue-Engineered Bone." Diss., North Dakota State University, 2018. https://hdl.handle.net/10365/27928.

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At its primary level (nm scale) bone is a nanocomposite consisting of a mineral (hydroxyapatite) phase which gives bone its strength and an organic (type I collagen) phase giving bone its fracture toughness. Hydroxyapatite, (HAP) Ca10(PO4)6(OH)2, is the most abundant mineral in the human body. Bone tissue has a complex hierarchical structure spanning multiple length scales (cm to nm). Characterization of mineral composition in biomineralized tissues such as bone at their primary level, is very challenging and requires instrumentation with nanometer-scale spatial resolution. Transmission electr

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13

Dang, Lei. "Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/687.

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Background: Osteoblasts participating in the inflammation regulation gradually obtain concerns. However, its role in joint inflammation of rheumatoid arthritis (RA) is largely unknown. Here, we investigated the role of osteoblastic pleckstrin homology domain-containing family O member 1 (PLEKHO1), a negative regulator of osteogenic lineage activity, in regulating joint inflammation in RA. Methods: The level of osteoblastic PLEKHO1 in RA patients and collagen-induced arthritis (CIA) mice was examined. The role of osteoblastic PLEKHO1 in joint inflammation was evaluated by a CIA mice model which

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14

Fernandes, Fernanda [UNESP]. "Análise do colo femoral de ratas adultas e senis após tratamento com ocitocina." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143823.

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Submitted by FERNANDA FERNANDES null (fernanda.fernandes.ata@gmail.com) on 2016-09-08T15:50:56Z No. of bitstreams: 1 DISSERTAÇÃO FERNANDA FERNANDES.pdf: 3056607 bytes, checksum: d763bb262cd01286f3a01d7fb1bcbab4 (MD5)<br>Approved for entry into archive by Juliano Benedito Ferreira (julianoferreira@reitoria.unesp.br) on 2016-09-09T13:14:26Z (GMT) No. of bitstreams: 1 fernandes_f_me_araca.pdf: 3056607 bytes, checksum: d763bb262cd01286f3a01d7fb1bcbab4 (MD5)<br>Made available in DSpace on 2016-09-09T13:14:26Z (GMT). No. of bitstreams: 1 fernandes_f_me_araca.pdf: 3056607 bytes, checksum: d763bb2

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15

Cha, Ming Chuan 1955. "The effect of zinc deficiency on the growth promoting actions of growth hormone and insulin-like growth factor-I /." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55484.

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The effect of zinc deficiency on the growth promoting effect of circulating IGF-I and the direct growth effect of GH on long bone growth were investigated. Food intake was decreased by lack of zinc in the diet. Tissue zinc content and plasma alkaline phosphatase activity were reduced by zinc deficiency. Systemic administration of human IGF-I increased the body weight, tail length and tibia epiphyseal cartilage width of control animals. This somatogenic action was impaired by zinc deficiency, as evidenced by continued weight loss, no increase in tail length and decreased tibial epiphyseal carti

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16

Alfonso, Durruty Marta Pilar. "Biosignificance of Harris lines as stress markers in relation to moderate undernutrition and bone growth velocity a New Zealand white rabbit model for the study of bone growth /." Diss., Online access via UMI:, 2008.

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17

Chan, Cheuk-wing Wilson, and 陳卓榮. "ER stress in the pathogenesis of osteochondrodysplasia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085192.

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18

Patel, Mamta Jashvantlal. "Suppression of osteoblast activity by disuse is prevented by low magnitude mechanical loading through a bone morphogenic protein-dependent Mechanism." Diss., Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22663.

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Musculoskeletal pathologies associated with decreased bone mass, including osteoporosis and disuse-induced bone loss, affect millions of Americans annually. Many pharmaceutical treatments have slowed osteoporosis, but there is still no countermeasure for bone loss observed in astronauts. Additionally, high magnitude and low frequency impact has been recognized to increase bone and muscle mass under normal but not microgravity conditions. However, a low magnitude and high frequency (LMHF) mechanical load experienced in activities such as postural control has also been shown to be anabolic to

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19

Biason, Talita Poli [UNESP]. "Densidade mineral óssea em adolescentes usuárias de anticoncepcional oral combinado." Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/99233.

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Made available in DSpace on 2014-06-11T19:29:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2013-02-22Bitstream added on 2014-06-13T18:59:46Z : No. of bitstreams: 1 000748628.pdf: 1456061 bytes, checksum: b5ef0d0192e00742b4d0ca806b84a009 (MD5)<br>Avaliar a densidade mineral óssea (DMO) e o conteúdo mineral ósseo (CMO) de adolescentes do sexo feminino, usuárias de anticoncepcional oral combinado (AOC) de baixa dosagem padronizado (EE 20 μg/ Desogestrel 150 μg), por período de um ano de seu uso e comparar os dados obtidos aos de adolescentes saudáveis da mesma faixa etária, não usuárias.

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20

Valverde, Franco Gladys 1972. "The role of fibroblast growth factor receptor 3 in post-natal cartilage and bone metabolism /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115917.

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FGFR 3 is one of a family of four high affinity receptors for FGF ligands. Activating mutations in FGFR 3 result in skeletal dysplasias that vary in severity from undetectable to neonatal lethal. Mice with congenital deficiency of FGFR3 develop severe kyphosis and skeletal overgrowth. FGFR3 is also expressed in calvarial pre-osteoblasts, osteoblast and articular chondrocytes, although it biological role in these cells remains undefined. By changing the genetic background of the Fgfr3-/- mice we were able to extend their lifespan and examine its impact on post-natal skeletal growth. To investig

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21

Pedroni, Marcus Vinícius Costa 1985. "Análise molecular e funcional dos genes formadores e reguladores do colágeno tipo I em pacientes com osteogênese imperfeita = Molecular and functional analysis of regulatory and structure-related genes of type I collagen in patients with osteogenesis imperfecta." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310406.

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Orientadores: Lília Freire Rodrigues de Souza Li, Carlos Eduardo Steiner<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências<br>Made available in DSpace on 2018-08-21T05:55:45Z (GMT). No. of bitstreams: 1 Pedroni_MarcusViniciusCosta_M.pdf: 5336681 bytes, checksum: 022385349dc7fcf62951d9f8c466360f (MD5) Previous issue date: 2012<br>Resumo: A Osteogênese Imperfeita (OI) é um distúrbio genético caracterizado por baixa massa e fragilidade óssea, e outras manifestações do tecido conjuntivo, decorrente de defeitos qualitativos ou quantitativos do colágeno tipo I. E

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22

Neves, Camila de Castro [UNESP]. "Estudo radiográfico retrospectivo de lesões ósseas mandibulares em cães." Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/89086.

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Made available in DSpace on 2014-06-11T19:23:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-12-20Bitstream added on 2014-06-13T20:11:28Z : No. of bitstreams: 1 neves_cc_me_jabo.pdf: 1932738 bytes, checksum: 2cc1bbf1472ac069094d5b9277cdf091 (MD5)<br>Universidade Estadual Paulista (UNESP)<br>Com o presente estudo relata-se a freqüência, localização e tipo de alterações encontradas em 77 cães com suspeita de lesão óssea na mandíbula, em imagens radiográficas, do arquivo do Setor de Radiologia do Hospital Veterinário Governador Laudo Natel (HV), da Faculdade de Ciências Agrárias e Vet

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23

Costin, Graham A. "Skeletal health education : effects of an educational intervention on health behaviour and health behaviour indicators of adolescent girls." Thesis, Queensland University of Technology, 1998.

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Education provides the critical link between the acquisition of knowledge about the determinants of skeletal health and the availability of that knowledge for application by the wider population. Hence it is one strategy with the capacity to reduce the increasing worldwide incidence of skeletal health problems, in particular osteoporosis. An expanding aged population requiring increasing care and support for osteoporosis-induced problems and suffering indicates the need for a concerted response incorporating education. Although osteoporosis is typically associated with old age, the nature

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24

Tag, Naima. "The added value of SPECT/CT in complicated osteomyelitis." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85553.

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ENGLISH ABSTRACT: Background: The detection of bone infection can be very difficult especially in bone with altered structure due to prior trauma or surgical procedures. Complicated osteomyelitis (COM) is becoming a public health problem especially with the difficult choice between, high cost surgery and prolonged courses of intravenous or oral antibiotic therapy, as well as the social and psychological effect of longterm disease and disability of the patient. The correct localisation of especially bone infection is still a challenge for the clinician. The single photon emission computed

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25

周志豪. "跟痛症內服中藥治療規律的文獻研究". HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1042.

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26

譚健斌. "股骨頭缺血性懷死的中醫藥治療文獻研究". HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/755.

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27

Guañabens, Gay Nuria. "Osteodistrofia de la cirrosis biliar primaria." Doctoral thesis, Universitat de Barcelona, 1987. http://hdl.handle.net/10803/22838.

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La cirrosis biliar primaria es una enfermedad hepática que se manifiesta por un patrón clínico, bioquímico e histológico de colestasis crónica. Su curso puede complicarse con el desarrollo de una patología metabólica ósea cuyo tipo, frecuencia y mecanismos patogenéticos no están bien establecidos. Esta tesis se ha realizado con el fin de analizar la prevalencia y tipo de enfermedad metabólica ósea que se asocia a la cirrosis biliar primaria (CBP) e investigar los factores que influyen en su desarrollo. 1) PACIENTES Y MÉTODOS Se han estudiado 20 pacientes con CBP (18M, 2 V) con una eda

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28

Goodyear, Simon R. "Physicochemical methods for measuring the properties of bone and their application to mouse models of disease." Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=133992.

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This thesis describes a toolbox of complementary techniques that together measure and mechanical properties of bone. Three-point bending is used to measure the mechanical properties of bone; micro computed tomography provides cortical geometry and parameters describing trabecular bone. The material properties, elastic modulus and density, are measured directly using ultrasound and Archimedes’ principle, while composition and bone chemistry are investigated by ashing and Raman microscopy. These methods are used to characterise bone from the naturally occurring Gunmetal mouse and the engineere

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29

Neves, Camila de Castro. "Estudo radiográfico retrospectivo de lesões ósseas mandibulares em cães /." Jaboticabal : [s.n.], 2006. http://hdl.handle.net/11449/89086.

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Orientador: Cíntia Lúcia Maniscalco<br>Banca: Júlio Carlos Canola<br>Banca: Jorge Luiz Oliveira Costa<br>Resumo: Com o presente estudo relata-se a freqüência, localização e tipo de alterações encontradas em 77 cães com suspeita de lesão óssea na mandíbula, em imagens radiográficas, do arquivo do Setor de Radiologia do Hospital Veterinário "Governador Laudo Natel" (HV), da Faculdade de Ciências Agrárias e Veterinárias, da Universidade Estadual Paulista (FCAV/UNESP), Câmpus de Jaboticabal, SP, no período de janeiro de 2001 a janeiro de 2006, correlacionando sexo, idade e raça dos animais. A pesq

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30

Mkhize, Felicity Nomfuzo. "Investigating the high incidence of bone disorders in a broiler farm : a case study." Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/3346.

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Thesis (MPhil (Animal Sciences))--University of Stellenbosch, 2006.<br>Rickets is described as a disease that affects young growing poultry. Poorly mineralized bones with thickened and irregular growth plates characterize it. The onset of rickets is characterized by a failure of mineralization of cartilage and bone. Other symptoms of rickets include reluctance to movement in affected birds. These birds will sit on their hocks and if startled they use their wings for balance. On necropsy, bones are soft and fragile and they have thickened growth plates. In this study 30% of the chicks aged betw

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31

Brock, Ryane Schmidt [UNESP]. "Retalho ósseo de gálea e periósteo preenchido com pó de osso: estido em coelhos." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/87352.

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Made available in DSpace on 2014-06-11T19:22:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-12-19Bitstream added on 2014-06-13T19:49:04Z : No. of bitstreams: 1 brock_rs_me_botfm.pdf: 602525 bytes, checksum: bd2115da27f5dda49225e5afda53918e (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Defeitos ósseos decorrentes de traumas, ressecções de tumores ou mesmo malformações congênitas, são encontrados com freqüência na prática médica. O tratamento destas deformidades é feito mediante reconstruções cirúrgicas, principalmente na cirurgia plástica, proporci

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32

Aguiar, Simone dos Santos. "Pesquisa da amplificação e/ou deleção genica atraves da tecnica de hibridização genomica comparativa (CGH) e da leção dos genes P53 e RB1 atraves da tecnica de hibridação in situ fluorescente (FISH) no tecido do tumor de crianças e adolescentes com ost." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312071.

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Orientador: Silvia Regina Brandalise<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-06T21:43:20Z (GMT). No. of bitstreams: 1 Aguiar_SimonedosSantos_D.pdf: 43958145 bytes, checksum: b9dafbbd99ad0e567b3c1f03a0c7b37e (MD5) Previous issue date: 2006<br>Resumo: Introdução Os osteossarcomas (OS) são tumores agressivos, primários de osso, com prognóstico reservado. As deleções dos genes supressores de tumor, RBl e P53, localizados nos cromossomos 13 e 17 respectivamente, são freqüentemente encontradas neste tipo de tumor

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33

Buck, Cecília Oliveira Barbosa 1975. "Estudo clínico-epidemiológico das osteocondrodisplasias de manifestação perinatal na América do Sul." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308793.

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Orientador: Denise Pontes Cavalcanti<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-18T22:10:26Z (GMT). No. of bitstreams: 1 Buck_CeciliaOliveiraBarbosa_D.pdf: 3074480 bytes, checksum: d8ed23fbbc34d4773afce0c5bb451361 (MD5) Previous issue date: 2011<br>Resumo: Osteocondrodisplasias (OCD) ou displasias esqueléticas são um grupo heterogêneo de doenças genéticas que afetam o crescimento. e o desenvolvimento do esqueleto e possuem alta morbimortalidade associada. Apesar dos avanços recentes no diagnóstico pré-natal e

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Abdelhadi, Mohamed Mohamed. "Posttransplantation bone disease : the effect of immunosuppressive drugs on bone: clinical and experimental studies /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-384-8/.

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Wedin, Rikard. "Metastatic bone disease /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3829-6/.

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Phan, Tuan (Tony). "Functional characterisation of an osteoclast-derived osteoblastic factor (ODOF)." University of Western Australia. School of Surgery and Pathology, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0028.

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[Truncated abstract] Bone is a living tissue and is maintained by the coordinate action of osteoblasts and osteoclasts. The intercellular communication between these two cells is the quintessential mechanism in bone remodelling. Unfortunately, the importance of this interaction is often neglected and its significance is only realised when disruption of this “cross-talk” results in debilitating bone diseases. Additionally, the number of known proteins that are involved in this “cross-talk”, especially those that are osteoclast-derived, and act specifically on osteoblasts, is limited. This discr

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Choi, Chung-yue. "Free radicals and bone marrow diseases a potential role of nitric oxide in graft-versus-host disease after bone marrow transplant /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23273367.

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Poulet, Blandine. "Characterising a model for non-invasive loading of the murine joint : initial studies into the interplay between mechanical and genetic factors in osteoarthritis." Thesis, Royal Veterinary College (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558982.

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Sarrión, Pérez-Caballero Patricia. "Estudio genético de dos fenotipos óseos: osteocondromatosis múltiple y alta masa ósea." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/127188.

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Mi trabajo de tesis está compuesto por dos estudios diferenciados. Por un lado, el análisis molecular de la Osteocondromatosis Múltiple (MO) en pacientes españoles y latinoamericanos. El uso combinado de dos métodos complementarios en la búsqueda de mutaciones (detección de la dosis génica y análisis de la secuencia de ADN) ha permitido descubrir la causa de MO en el 95% de los pacientes españoles y en el 83% de los pacientes latinoamericanos analizados. Se han genotipado los exones y las regiones intrónicas flanqueantes de los genes causantes de la MO, EXT1 y EXT2, en 39 pacientes españoles

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Putman, Melissa. "Cystic Fibrosis Related Bone Disease." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17613728.

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Over the past several decades, life expectancy for patients with cystic fibrosis (CF) has increased significantly. As patients live longer, other nonpulmonary co-morbidities related to CF have become increasingly prevalent, including CF-related bone disease. Because CF related bone disease has only recently emerged as a clinical problem, and the underlying bone alterations and pathogenesis of this condition have not been established. This thesis explores the underlying bone micro-architecture and strength alterations found in adults with CF using state-of-the-art bone imaging techniques and e

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Hauser, Barbara. "Mechanism of bone loss in rheumatic diseases." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22823.

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Osteoporosis and fragility fractures are recognized complications of inflammatory rheumatic diseases. This is thought to result from the effects of chronic inflammation, relative immobility and corticosteroid use. A rare syndrome of osteoporosis in a patient with coeliac disease has been described which results from production of neutralizing antibodies to the bone protective protein osteoprotegerin (OPG). The aim of my thesis is to evaluate prevalence and clinical predictors of osteoporosis in a contemporary cohort of patients with rheumatoid arthritis (RA) and to investigate the role of OPG

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蔡聰筎 and Chung-yue Choi. "Free radicals and bone marrow diseases: a potential role of nitric oxide in graft-versus-host disease after bonemarrow transplant." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31224222.

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Garazdiuk, O. I. "The role of bone disorders in chronic kidney disease and systemic connective tissue diseases progression, evaluation and therapeutic approaches." Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18586.

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Ding, Hongliu. "Bone Health and Coronary Heart Disease in Postmenopausal Women with Breast Cancer Treated with Tamoxifen: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/404.

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Breast cancer, osteoporosis, and coronary heart disease (CHD) are three major threats to women’s health. Postmenopausal women with breast cancer are also at high risk for osteoporosis and CHD. Adjuvant tamoxifen therapy is not only an effective treatment for breast cancer, but has been shown to have a beneficial effect on bone and the cardiovascular system. Although tamoxifen has been convincingly demonstrated to be able to preserve bone mineral density (BMD), an unexpected increase of risk of fractures in patients treated with tamoxifen has been reported. The findings of the association of ta

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Langford-Smith, Kia Jane. "Non-myeloablative bone marrow transplantation for Mucopolysaccharide diseases." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nonmyeloablative-bone-marrow-transplantation-for-mucopolysaccharide-diseases(5d3fd9c5-01f2-42aa-81ed-a2ce6ef140fe).html.

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The Mucopolysaccharide (MPS) diseases are a group of lysosomal storage disorders, caused by a lack of the enzymes required for catabolism of glycosaminoglycans (GAGs), leading to severe neurological decline, skeletal deformities, organomegaly, cardiac and respiratory compromise, and premature death. The severe form of MPS I, Hurler syndrome, can be successfully treated using haematopoietic stem cell transplantation (HSCT), but the risks associated with myeloablation and immune suppression limit the broader application of HSCT to attenuated diseases. Successful engraftment in MPS I has been dif

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Nixon, Matthew Frank. "Metabolic bone disease and arthroplasty loosening." Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/8448.

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Joint degeneration requiring arthroplasty surgery and the consequences of osteoporosis are the two fundamental pathologies in orthopaedics. There are around 44,000 Medline-indexed journals about osteoporosis, and around 30,000 concerned with arthroplasty. However despite both typically occurring in a similar elderly population, only 350 (less than 0.5%) are cross-indexed. Aseptic loosening is the commonest cause of hip arthroplasty failure, with revision surgery being the only current treatment. Recent work has increased the understanding of the aetiology of aseptic loosening and studies sugge

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Lucas, Gavin J. A. "Genetics of Paget's disease of bone." Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430978.

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Chapter 3 describes the results of mutation screening of a candidate gene, SQSTM1, from one of the linkage regions implicated in the pathogenesis of PDB in families of mainly British descent. Seven mutations that segregated with the disease were identified and all clustered in the ubiquitin-associated (UBA) domain of the protein. In Chapter 4, an association study and haplotype analysis was conducted in PDB families using SNPs in SQSTM1. This revealed that the most common SQSTM1 mutation was predominantly carried on one of two common haplotype backgrounds, suggesting that a strong founder ef

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Hocking, Lynne J. "Genetics of Paget's disease of bone." Thesis, University of Aberdeen, 2002. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU160239.

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In Chapter 4, I investigated the roles of the RANK signalling partners RANK ligand (RANKL) and osteoprotegerin (OPG) in the pathogenesis of sporadic and familial PDB. One polymorphism in the RANK gene and five polymorphisms in the OPG gene were examined in sporadic PDB cases and in sex- and age-matched controls. No allele-disease or genotype-disease association was observed for the <i>RANKL </i>polymorphism, suggesting RANKL is not directly involved in susceptibility to sporadic PDB. Genotypes at two <i>OPG</i> polymorphisms did significantly predict disease status in individuals affected with

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Laketic-Ljubojevic, Ira. "Glutamate signalling in bone cells." Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311080.

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Reid, Carol Anne. "Texture analysis of bone mineralisation surfaces." Thesis, University of Glasgow, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287800.

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