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Статті в журналах з теми "C26 cells"

Автор: Grafiati

Опубліковано: 20 лютого 2024

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1

Kutkowska-Kaźmierczak, Anna, Małgorzata Rydzanicz, Aleksander Chlebowski, et al. "Dominant ELOVL1 mutation causes neurological disorder with ichthyotic keratoderma, spasticity, hypomyelination and dysmorphic features." Journal of Medical Genetics 55, no. 6 (2018): 408–14. http://dx.doi.org/10.1136/jmedgenet-2017-105172.

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BackgroundIchthyosis and neurological involvement occur in relatively few known Mendelian disorders caused by mutations in genes relevant both for epidermis and neural function.ObjectivesTo identify the cause of a similar phenotype of ichthyotic keratoderma, spasticity, mild hypomyelination (on MRI) and dysmorphic features (IKSHD) observed in two unrelated paediatric probands without family history of disease.MethodsWhole exome sequencing was performed in both patients. The functional effect of prioritised variant in ELOVL1 (very-long-chain fatty acids (VLCFAs) elongase) was analysed by VLCFA

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2

Schutgens, R. B., I. W. Bouman, A. A. Nijenhuis, R. J. Wanders, and M. E. Frumau. "Profiles of very-long-chain fatty acids in plasma, fibroblasts, and blood cells in Zellweger syndrome, X-linked adrenoleukodystrophy, and rhizomelic chondrodysplasia punctata." Clinical Chemistry 39, no. 8 (1993): 1632–37. http://dx.doi.org/10.1093/clinchem/39.8.1632.

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Abstract Profiles of saturated very-long-chain (&gt; C22) fatty acids were studied in plasma, fibroblasts, erythrocytes, platelets, and leukocytes of patients affected by peroxisomal disorders such as Zellweger syndrome, X-linked adrenoleukodystrophy (X-ALD), and classic rhizomelic chondrodysplasia punctata (RCDP) and in controls. In Zellweger patients, the concentration of hexacosanoic acid (C26:0) and the C26:0/C22:0 ratio are greatly increased in plasma and fibroblasts. However, the plasma concentration of docosanoic acid (C22:0) is greatly decreased. Also in platelets, leukocytes, and

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3

Yamaguchi, A., T. Katagiri, T. Ikeda, et al. "Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro." Journal of Cell Biology 113, no. 3 (1991): 681–87. http://dx.doi.org/10.1083/jcb.113.3.681.

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The in vitro effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on osteogenic and myogenic differentiation was examined in two clonal cell lines of rat osteoblast-like cells at different differentiation stages, ROB-C26 (C26) and ROB-C20 (C20). The C26 is a potential osteoblast precursor cell line that is also capable of differentiating into muscle cells and adipocytes; the C20 is a more differentiated osteoblastic cell line. Proliferation was stimulated by rhBMP-2 in C26 cells, but inhibited in C20 cells. rhBMP-2 greatly increased alkaline phosphate (ALP) activity in C26 cells,

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4

Zarrouk, Amira, Anne Vejux, Thomas Nury, et al. "Induction of Mitochondrial Changes Associated with Oxidative Stress on Very Long Chain Fatty Acids (C22:0, C24:0, or C26:0)-Treated Human Neuronal Cells (SK-NB-E)." Oxidative Medicine and Cellular Longevity 2012 (2012): 1–15. http://dx.doi.org/10.1155/2012/623257.

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In Alzheimer's disease, lipid alterations point towards peroxisomal dysfunctions. Indeed, a cortical accumulation of saturated very long chain fatty acids (VLCFAs: C22:0, C24:0, C26:0), substrates for peroxisomalβ-oxidation, has been found in Alzheimer patients. This study was realized to investigate the effects of VLCFAs at the mitochondrial level since mitochondrial dysfunctions play crucial roles in neurodegeneration. On human neuronal SK-NB-E cells treated with C22:0, C24:0, or C26:0 (0.1–20 μM; 48 h), an inhibition of cell growth and mitochondrial dysfunctions were observed by cell counti

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5

Santalova, Elena A., Alexandra S. Kuzmich, Ekaterina A. Chingizova, Ekaterina S. Menchinskaya, Evgeny A. Pislyagin, and Pavel S. Dmitrenok. "Phytoceramides from the Marine Sponge Monanchora clathrata: Structural Analysis and Cytoprotective Effects." Biomolecules 13, no. 4 (2023): 677. http://dx.doi.org/10.3390/biom13040677.

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In our research on sphingolipids from marine invertebrates, a mixture of phytoceramides was isolated from the sponge Monanchora clathrata (Western Australia). Total ceramide, ceramide molecular species (obtained by RP-HPLC, high-performance liquid chromatography on reversed-phase column) and their sphingoid/fatty acid components were analyzed by NMR (nuclear magnetic resonance) spectroscopy and mass spectrometry. Sixteen new (1b, 3a, 3c, 3d, 3f, 3g, 5c, 5d, 5f, 5g, 6b–g) and twelve known (2b, 2e, 2f, 3b, 3e, 4a–c, 4e, 4f, 5b, 5e) compounds were shown to contain phytosphingosine-type backbones

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6

Yamada, T., N. Kubushiro, K. Shigemasa, T. Ikeda та M. Takagi. "Effects of Transforming Growth Factor-β1 on Decorin Expression by Undifferentiated Osteoblastic Cells". Microscopy and Microanalysis 3, S2 (1997): 187–88. http://dx.doi.org/10.1017/s1431927600007820.

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Decorin is the predominant proteoglycan isolated from bone of several animal species. Bone matrix decorin appears to bind transforming growth factor β (TGF-β) and enhances its bioactivity. TGF-β is stored in bone matrix in abundant amounts and modulates the synthesis of bone matrix proteins by osteoblasts. Thus it appears to play a role in regulation of bone formation during the bone remodeling process. The effect of TGF-β on decorin expression in bone cells has been evaluated in murine osteoblastic cells, but the results are divergent depending on the experimental conditions and cell types us

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7

Eisenkolb, Marlis, Christoph Zenzmaier, Erich Leitner, and Roger Schneiter. "A Specific Structural Requirement for Ergosterol in Long-chain Fatty Acid Synthesis Mutants Important for Maintaining Raft Domains in Yeast." Molecular Biology of the Cell 13, no. 12 (2002): 4414–28. http://dx.doi.org/10.1091/mbc.e02-02-0116.

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Fungal sphingolipids contain ceramide with a very-long-chain fatty acid (C26). To investigate the physiological significance of the C26-substitution on this lipid, we performed a screen for mutants that are synthetically lethal with ELO3. Elo3p is a component of the ER-associated fatty acid elongase and is required for the final elongation cycle to produce C26 from C22/C24 fatty acids.elo3Δ mutant cells thus contain C22/C24- instead of the natural C26-substituted ceramide. We now report that under these conditions, an otherwise nonessential, but also fungal-specific, structural modification of

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8

SCHNEITER, Roger, Britta BRÜGGER, Clare M. AMANN, et al. "Identification and biophysical characterization of a very-long-chain-fatty-acid-substituted phosphatidylinositol in yeast subcellular membranes." Biochemical Journal 381, no. 3 (2004): 941–49. http://dx.doi.org/10.1042/bj20040320.

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Morphological analysis of a conditional yeast mutant in acetyl-CoA carboxylase acc1ts/mtr7, the rate-limiting enzyme of fatty acid synthesis, suggested that the synthesis of C26 VLCFAs (very-long-chain fatty acids) is important for maintaining the structure and function of the nuclear membrane. To characterize this C26-dependent pathway in more detail, we have now examined cells that are blocked in pathways that require C26. In yeast, ceramide synthesis and remodelling of GPI (glycosylphosphatidylinositol)-anchors are two pathways that incorporate C26 into lipids. Conditional mutants blocked i

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9

Rodolfo, M., C. Zilocchi, C. Melani, et al. "Immunotherapy of experimental metastases by vaccination with interleukin gene-transduced adenocarcinoma cells sharing tumor-associated antigens. Comparison between IL-12 and IL-2 gene-transduced tumor cell vaccines." Journal of Immunology 157, no. 12 (1996): 5536–42. http://dx.doi.org/10.4049/jimmunol.157.12.5536.

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Abstract We have compared the therapeutic activity and characterized the antitumor response induced by IL-12 and IL-2 gene-transduced tumor cell vaccines. Mice bearing lung metastases of the BALB/c colon carcinoma C51 were treated with syngenic, histologically related, and antigenically cross-reacting irradiated IL-12 (C26/IL12) or IL-2 (C26/IL2) gene-transduced C26 tumor cells given s.c. Vaccination with C26/IL12 cells cured 40% of mice, while vaccination with C26/IL2 cells reduced the number of metastatic nodules without affecting survival. Despite this difference, similar antitumor CTL acti

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10

Smakman, Niels, Diana J. M. van den Wollenberg, Inne H. M. Borel Rinkes, Rob C. Hoeben, and Onno Kranenburg. "Sensitization to Apoptosis Underlies KrasD12-Dependent Oncolysis of Murine C26 Colorectal Carcinoma Cells by Reovirus T3D." Journal of Virology 79, no. 23 (2005): 14981–85. http://dx.doi.org/10.1128/jvi.79.23.14981-14985.2005.

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ABSTRACT Reovirus T3D is an oncolytic agent that preferentially targets tumor cells expressing an activated Ras oncogene. Ras signaling interferes with the cellular stress response that inhibits translation of reovirus RNAs. Murine C26 colorectal carcinoma cells express a mutant KrasD12 gene. Reovirus T3D efficiently kills C26 cells, but not C26 cells in which the KrasD12 mRNA is stably repressed by expression of KrasD12-directed short-hairpin RNAs. Surprisingly, neither reovirus T3D protein synthesis nor T3D virus yields were suppressed by deletion of KrasD12. Rather, reovirus-induced tumor c

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11

Vilchèze, Catherine, Hector R. Morbidoni, Torin R. Weisbrod, et al. "Inactivation of the inhA-Encoded Fatty Acid Synthase II (FASII) Enoyl-Acyl Carrier Protein Reductase Induces Accumulation of the FASI End Products and Cell Lysis of Mycobacterium smegmatis." Journal of Bacteriology 182, no. 14 (2000): 4059–67. http://dx.doi.org/10.1128/jb.182.14.4059-4067.2000.

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ABSTRACT The mechanism of action of isoniazid (INH), a first-line antituberculosis drug, is complex, as mutations in at least five different genes (katG, inhA, ahpC,kasA, and ndh) have been found to correlate with isoniazid resistance. Despite this complexity, a preponderance of evidence implicates inhA, which codes for an enoyl-acyl carrier protein reductase of the fatty acid synthase II (FASII), as the primary target of INH. However, INH treatment of Mycobacterium tuberculosis causes the accumulation of hexacosanoic acid (C26:0), a result unexpected for the blocking of an enoyl-reductase. To

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12

Pekkala, Satu, Anniina Keskitalo, Emilia Kettunen, et al. "Blocking Activin Receptor Ligands Is Not Sufficient to Rescue Cancer-Associated Gut Microbiota—A Role for Gut Microbial Flagellin in Colorectal Cancer and Cachexia?" Cancers 11, no. 11 (2019): 1799. http://dx.doi.org/10.3390/cancers11111799.

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Colorectal cancer (CRC) and cachexia are associated with the gut microbiota and microbial surface molecules. We characterized the CRC-associated microbiota and investigated whether cachexia affects the microbiota composition. Further, we examined the possible relationship between the microbial surface molecule flagellin and CRC. CRC cells (C26) were inoculated into mice. Activin receptor (ACVR) ligands were blocked, either before tumor formation or before and after, to increase muscle mass and prevent muscle loss. The effects of flagellin on C26-cells were studied in vitro. The occurrence of s

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13

Zhou, Jie, Marcia R. Terluk, Paul J. Orchard, James C. Cloyd, and Reena V. Kartha. "N-Acetylcysteine Reverses the Mitochondrial Dysfunction Induced by Very Long-Chain Fatty Acids in Murine Oligodendrocyte Model of Adrenoleukodystrophy." Biomedicines 9, no. 12 (2021): 1826. http://dx.doi.org/10.3390/biomedicines9121826.

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The accumulation of saturated very long-chain fatty acids (VLCFA, ≥C22:0) due to peroxisomal impairment leads to oxidative stress and neurodegeneration in X-linked adrenoleukodystrophy (ALD). Among the neural supporting cells, myelin-producing oligodendrocytes are the most sensitive to the detrimental effect of VLCFA. Here, we characterized the mitochondrial dysfunction and cell death induced by VLFCA, and examined whether N-acetylcysteine (NAC), an antioxidant, prevents the cytotoxicity. We exposed murine oligodendrocytes (158 N) to hexacosanoic acid (C26:0, 1–100 µM) for 24 h and measured re

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14

Zilocchi, Chiara, Antonella Stoppacciaro, Claudia Chiodoni, Mariella Parenza, Nadia Terrazzini та Mario P. Colombo. "Interferon γ–independent Rejection of Interleukin 12–transduced Carcinoma Cells Requires CD4+ T Cells and Granulocyte/Macrophage Colony–stimulating Factor". Journal of Experimental Medicine 188, № 1 (1998): 133–43. http://dx.doi.org/10.1084/jem.188.1.133.

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We analyzed the ability of interferon (IFN)-γ knockout mice (GKO) to reject a colon carcinoma transduced with interleukin (IL)-12 genes (C26/IL-12). Although the absence of IFN-γ impaired the early response and reduced the time to tumor onset in GKO mice, the overall tumor take rate was similar to that of BALB/c mice. In GKO mice, C26/IL-12 tumors had a reduced number of infiltrating leukocytes, especially CD8 and natural killer cells. Analysis of the tumor site, draining nodes, and spleens of GKO mice revealed reduced expression of IFN- inducible protein 10 and monokine induced by γ-IFN. Desp

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15

Rojas-Tapias, Daniel, Oriana Ortega Sierra, Diego Rivera Botía, and Ruth Bonilla. "Preservation of Azotobacter chroococcum vegetative cells in dry polymers." Universitas Scientiarum 20, no. 2 (2014): 201. http://dx.doi.org/10.11144/javeriana.sc20-2.pacv.

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We studied the preservation of Azotobacter chroococcum C26 using three dry polymers: carrageenin, sodium alginate, and HPMC, using a method of accelerated degradation. Bacterial viability, as response variable, was measured at three temperatures in four different times, which was followed by calculation of bacterial degradation rates. Results showed that temperature, time of storage, and protective agent influenced both viability and degradation rates (P;lt;0.05). We observed, using the Arrhenius thermodynamic model, that the use of polymers increased the activation energy of bacterial degrada

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16

Cerantola, Vanessa, Christine Vionnet, Olivier F. Aebischer, Titus Jenny, Jens Knudsen, and Andreas Conzelmann. "Yeast sphingolipids do not need to contain very long chain fatty acids." Biochemical Journal 401, no. 1 (2006): 205–16. http://dx.doi.org/10.1042/bj20061128.

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Synthesis of VLCFAs (very long chain fatty acids) and biosynthesis of DHS (dihydrosphingosine) both are of vital importance for Saccharomyces cerevisiae. The bulk of VLCFAs and DHS are used for ceramide synthesis by the Lag1p (longevity-assurance gene 1)/Lac1p (longevity-assurance gene cognate 1)/Lip1p (Lag1p/Lac1p interacting protein) ceramide synthase. LAG1 and LAC1 are redundant but LIP1 is essential. Here we show that 4Δ (lag1Δlac1Δypc1Δydc1Δ) cells devoid of all known endogenous ceramide synthesis pathways are unviable but can be rescued by the expression of Lass5, a mouse LAG1 homologue.

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17

Bosson, Régine, and Andreas Conzelmann. "Multiple functions of inositolphosphorylceramides in the formation and intracellular transport of glycosylphosphatidylinositol-anchored proteins in yeast." Biochemical Society Symposia 74 (January 12, 2007): 199–209. http://dx.doi.org/10.1042/bss2007c17.

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The mature sphingolipids of yeast consist of IPCs (inositolphosphorylceramides) and glycosylated derivatives thereof. Beyond being an abundant membrane constituent in the organelles of the secretory pathway, IPCs are also used to constitute the lipid moiety of the majority of GPI (glycosylphosphatidylinositol) proteins, while a minority of GPI proteins contain PI (phosphatidylinositol). Thus all GPI anchor lipids (as well as free IPCs) typically contain C26 fatty acids. However, the primary GPI lipid that isadded to newly synthesized proteins in the endoplasmic reticulum consists of a PI with

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18

Aquila, Giorgio, Andrea David Re Cecconi, Mara Forti, et al. "Trabectedin and Lurbinectedin Extend Survival of Mice Bearing C26 Colon Adenocarcinoma, without Affecting Tumor Growth or Cachexia." Cancers 12, no. 8 (2020): 2312. http://dx.doi.org/10.3390/cancers12082312.

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Trabectedin (ET743) and lurbinectedin (PM01183) limit the production of inflammatory cytokines that are elevated during cancer cachexia. Mice carrying C26 colon adenocarcinoma display cachexia (i.e., premature death and body wasting with muscle, fat and cardiac tissue depletion), high levels of inflammatory cytokines and subsequent splenomegaly. We tested whether such drugs protected these mice from cachexia. Ten-week-old mice were inoculated with C26 cells and three days later randomized to receive intravenously vehicle or 0.05 mg/kg ET743 or 0.07 mg/kg PM01183, three times a week for three w

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19

ZĂHAN, Marius, Ana Maria MUŢOIU, Liliana OLENIC, Ileana MICLEA, Adriana CRISTE, and Vasile MICLEA. "Cytotoxic Effect of Chitosan-Gold Nanoparticles on Two Cell Lines in Culture." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies 74, no. 2 (2017): 139. http://dx.doi.org/10.15835/buasvmcn-asb:0017.

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Among metallic nanoparticles gold possess several unique properties. It has been argued that AuNPs have significant toxicity both in vitro and in vivo but that coating may partially prevent harmful effects. Chitosan is a natural polysaccharide derivative of chitin known to have immunoenhancing effects, antitumor, antifungal and antimicrobial activities. The aim of this study was to investigate the cytotoxic effect of chitosan-AuNPs on C26 (murine colon carcinoma) and HeLa (human cervix carcinoma) cell lines. C26 and HeLa cells were exposed to 10 and 60 nm sized chitosan-AuNPs at five different

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20

Lokireddy, Sudarsanareddy, Isuru Wijerupage Wijesoma, Sabeera Bonala, et al. "Myostatin is a novel tumoral factor that induces cancer cachexia." Biochemical Journal 446, no. 1 (2012): 23–36. http://dx.doi.org/10.1042/bj20112024.

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Humoral and tumoral factors collectively promote cancer-induced skeletal muscle wasting by increasing protein degradation. Although several humoral proteins, namely TNFα (tumour necrosis factor α) and IL (interleukin)-6, have been shown to induce skeletal muscle wasting, there is a lack of information regarding the tumoral factors that contribute to the atrophy of muscle during cancer cachexia. Therefore, in the present study, we have characterized the secretome of C26 colon cancer cells to identify the tumoral factors involved in cancer-induced skeletal muscle wasting. In the present study, w

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21

Bosson, Régine, Malika Jaquenoud, and Andreas Conzelmann. "GUP1 of Saccharomyces cerevisiae Encodes an O-Acyltransferase Involved in Remodeling of the GPI Anchor." Molecular Biology of the Cell 17, no. 6 (2006): 2636–45. http://dx.doi.org/10.1091/mbc.e06-02-0104.

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The anchors of mature glycosylphosphatidylinositol (GPI)-anchored proteins of Saccharomyces cerevisiae contain either ceramide or diacylglycerol with a C26:0 fatty acid in the sn2 position. The primary GPI lipid added to newly synthesized proteins in the ER consists of diacylglycerol with conventional C16 and C18 fatty acids. Here we show that GUP1 is essential for the synthesis of the C26:0-containing diacylglycerol anchors. Gup1p is an ER membrane protein with multiple membrane-spanning domains harboring a motif that is characteristic of membrane-bound O-acyl-transferases (MBOAT). Gup1Δ cell

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22

Plas, Rogier L. C., Mieke Poland, Joyce Faber, et al. "A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice." International Journal of Molecular Sciences 20, no. 20 (2019): 4978. http://dx.doi.org/10.3390/ijms20204978.

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Background: Dietary supplementation with leucine and fish oil rich in omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) has previously been shown to reduce cachexia-related outcomes in C26 tumour-bearing mice. To further explore associated processes and mechanisms we investigated changes in plasma Ca2+ levels, the involvement of parathyroid hormone related protein (PTHrP), and its possible interactions with cyclooxygenase 2 (COX-2). Methods: CD2F1 mice were subcutaneously inoculated with C26 adenocarcinoma cells or sham treated and divided in: (1) controls, (2) tum

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23

Fujita, Morihisa, Mariko Umemura, Takehiko Yoko-o, and Yoshifumi Jigami. "PER1 Is Required for GPI-Phospholipase A2 Activity and Involved in Lipid Remodeling of GPI-anchored Proteins." Molecular Biology of the Cell 17, no. 12 (2006): 5253–64. http://dx.doi.org/10.1091/mbc.e06-08-0715.

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Glycosylphoshatidylinositol (GPI) anchors are remodeled during their transport to the cell surface. Newly synthesized proteins are transferred to a GPI anchor, consisting of diacylglycerol with conventional C16 and C18 fatty acids, whereas the lipid moiety in mature GPI-anchored proteins is exchanged to either diacylglycerol containing a C26:0 fatty acid in the sn-2 position or ceramide in Saccharomyces cerevisiae. Here, we report on PER1, a gene encoding a protein that is required for the GPI remodeling pathway. We found that GPI-anchored proteins could not associate with the detergent-resist

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24

Patras, Laura, Marcel H. A. M. Fens, Pieter Vader, et al. "Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro." International Journal of Molecular Sciences 21, no. 17 (2020): 5951. http://dx.doi.org/10.3390/ijms21175951.

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Extracellular vesicles (EV) secreted in the tumour microenvironment (TME) are emerging as major antagonists of anticancer therapies by orchestrating the therapeutic outcome through altering the behaviour of recipient cells. Recent evidence suggested that chemotherapeutic drugs could be responsible for the EV-mediated tumour–stroma crosstalk associated with cancer cell drug resistance. Here, we investigated the capacity of tumour EV (TEV) secreted by normoxic and hypoxic (1% oxygen) C26 cancer cells after doxorubicin (DOX) treatment to alter the response of naïve C26 cells and RAW 264.7 macroph

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25

Lautaoja, Juulia H., Maciej Lalowski, Tuuli A. Nissinen, et al. "Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade." American Journal of Physiology-Endocrinology and Metabolism 316, no. 5 (2019): E852—E865. http://dx.doi.org/10.1152/ajpendo.00526.2018.

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Cancer-associated cachexia reduces survival, which has been attenuated by blocking the activin receptor type 2B (ACVR2B) ligands in mice. The purpose of this study was to unravel the underlying physiology and novel cachexia biomarkers by use of the colon-26 (C26) carcinoma model of cancer cachexia. Male BALB/c mice were subcutaneously inoculated with C26 cancer cells or vehicle control. Tumor-bearing mice were treated with vehicle (C26+PBS) or soluble ACVR2B either before (C26+sACVR/b) or before and after (C26+sACVR/c) tumor formation. Skeletal muscle and serum metabolomics analysis was conduc

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26

McNamara, M. K., and J. S. Wiley. "Passive permeability of human red blood cells to calcium." American Journal of Physiology-Cell Physiology 250, no. 1 (1986): C26—C31. http://dx.doi.org/10.1152/ajpcell.1986.250.1.c26.

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Ca2+ influx was measured into human erythrocytes in which efflux was blocked by either introduction of an intracellular Ca2+ chelator, introduction of the Ca2+ chelator followed by ATP depletion, or depletion of the Ca2+ pump cofactors ATP and Mg2+. The Ca2+ influx under all three conditions was 14-20 mumol . 1 cells-1 . h-1, which is an order of magnitude higher than the influx previously reported for cells depleted of either ATP or Mg2+ separately. The difference between the two values was explained by the finding of substantial Ca2+ efflux from the Ca2+-loaded ATP-depleted cells, whereas th

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27

Inoue, M., N. Fujishiro, and I. Imanaga. "Retardation of cation channel deactivation by mitochondrial dysfunction in adrenal medullary cells." American Journal of Physiology-Cell Physiology 278, no. 1 (2000): C26—C32. http://dx.doi.org/10.1152/ajpcell.2000.278.1.c26.

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The mechanism for cyanide (CN) activation of a nonselective cation (NS) channel coupled with a muscarinic receptor in a guinea pig chromaffin cell was studied with the perforated-patch method. Bath application of a protein kinase inhibitor resulted in a dose-dependent inhibition of muscarine-induced current ( I M) but had no apparent effect on the CN-induced current ( I CN). On the other hand, production of I CN occluded muscarine activation of NS channels in an amplitude-dependent manner. Deactivation of I M after washout was retarded while I CN was also active, and the extent of the retardat

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Jørgensen, Nanna Koschmieder, Stine Falsig Petersen, and Else Kay Hoffmann. "Thrombin-, bradykinin-, and arachidonic acid-induced Ca2+ signaling in Ehrlich ascites tumor cells." American Journal of Physiology-Cell Physiology 276, no. 1 (1999): C26—C37. http://dx.doi.org/10.1152/ajpcell.1999.276.1.c26.

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Stimulation of single Ehrlich ascites tumor cells with agonists (bradykinin, thrombin) and with arachidonic acid (AA) induces increases in the free intracellular Ca2+ concentration ([Ca2+]i) in the presence and absence of extracellular Ca2+, measured using the Ca2+-sensitive probe fura 2. Sequential stimulation with two agonists elicits sequential increases in [Ca2+]i, unlike addition of the same agonist twice. Bradykinin and thrombin have additive effects on [Ca2+]iin Ca2+-free medium. The phosphoinositidase C inhibitor U-73122 inhibits the agonist-induced increases in [Ca2+]i, whereas ryanod

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Porfire, Alina, Ioan Tomuta, Dana Muntean, et al. "Optimizing long-circulating liposomes for delivery of simvastatin to C26 colon carcinoma cells." Journal of Liposome Research 25, no. 4 (2014): 261–69. http://dx.doi.org/10.3109/08982104.2014.987787.

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Zare, Fatemeh. "Controlling role of Ly6Chigh Monocytes in breast cancer and C26 colon carcinoma." Journal of Immunology 196, no. 1_Supplement (2016): 211.13. http://dx.doi.org/10.4049/jimmunol.196.supp.211.13.

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Abstract Tumor microenvironment encompasses a wide variety of immune cells, which macrophages comprise the most dominant portion of them and thus are the major players in the connection between inflammation and cancer. These tumor-associated macrophages (TAMs) are derived from blood monocyte precursors and subsequently acquire distinct characteristics as a result of tumor micro-environmental cues. Monocytes are a heterogeneous population in the blood with an enormous plasticity whose fate and functions are dictated by the microenvironment. Therefore, the roles of specific Monocytes subsets in

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Angelotti, Austin, Rachel Cole, Amy Webb, Maciej Pietrzak, and Martha Belury. "Diet-Induced Gene Expression Changes of Cachectic Muscle, Adipose, and Liver." Current Developments in Nutrition 6, Supplement_1 (2022): 234. http://dx.doi.org/10.1093/cdn/nzac052.001.

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Abstract Objectives Cancer cachexia is a systemic disease characterized by muscle and adipose loss that cannot be reversed by increasing caloric intake. Our previous research has shown insulin resistance precedes cancer cachexia in the C26 mouse model of cachexia, and a diet high in linoleic acid, the essential omega-6 polyunsaturated fatty acid, attenuates the C26-induced insulin resistance. Therefore, to better understand how dietary linoleic acid is improving insulin sensitivity, we characterized gene expression changes in three major tissues responsible for controlling insulin sensitivity:

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Serrao, Simone, Cristina Contini, Giulia Guadalupi, et al. "Salivary Cystatin D Interactome in Patients with Systemic Mastocytosis: An Exploratory Study." International Journal of Molecular Sciences 24, no. 19 (2023): 14613. http://dx.doi.org/10.3390/ijms241914613.

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Mastocytosis, a rare blood disorder characterized by the proliferation of clonal abnormal mast cells, has a variegated clinical spectrum and diagnosis is often difficult and delayed. Recently we proposed the cathepsin inhibitor cystatin D-R26 as a salivary candidate biomarker of systemic mastocytosis (SM). Its C26 variant is able to form multiprotein complexes (mPCs) and since protein–protein interactions (PPIs) are crucial for studying disease pathogenesis, potential markers, and therapeutic targets, we aimed to define the protein composition of the salivary cystatin D-C26 interactome associa

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Takayama, Takuma, Taro Shimizu, Amr S. Abu Lila, et al. "Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil®) in C26 Tumor-Bearing Immunocompetent Mice." Pharmaceutics 12, no. 10 (2020): 990. http://dx.doi.org/10.3390/pharmaceutics12100990.

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Doxorubicin (DXR) has been reported to have direct cytotoxicity against cancer cells and indirect immunotoxicity by modulation of host antitumor immunity. Hence, it may prevent cancer progression by a dual mechanism. Doxil®, a formulation of DXR encapsulated in polyethylene glycol modified (PEGylated) liposomes, is the most widely used of the clinically approved liposomal anticancer drugs. However, the effect of Doxil® on host antitumor immunity is not well understood. In this study, Doxil® efficiently suppressed tumor growth in immunocompetent mice bearing C26 murine colorectal carcinomas, bu

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Chitti, Sai V., Akbar L. Marzan, Sanjay Shahi, Taeyoung Kang, Pamali Fonseka, and Suresh Mathivanan. "Repurposing of Antibiotic Sulfisoxazole Inhibits Lipolysis in Pre-Clinical Model of Cancer-Associated Cachexia." Biology 10, no. 8 (2021): 700. http://dx.doi.org/10.3390/biology10080700.

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Clinical management of cancer-associated cachexia, a multi-organ wasting syndrome, has been challenging without effective treatment strategies. An effective treatment that directly targets cancer-induced wasting is desperately needed to improve the quality of life and the survival of cancer patients. Recently, an antibiotic SFX was shown to have anti-tumour and anti-metastatic effects in mouse models of breast cancer. Hence, in this study, we examined the efficacy of SFX in the treatment of cancer-induced cachexia. C26 cachexic mice models were administered with SFX, and the tumour volume and

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Mueller, Noomi, Takayuki Sassa, Susanne Morales-Gonzalez, et al. "De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy." Journal of Medical Genetics 56, no. 3 (2018): 164–75. http://dx.doi.org/10.1136/jmedgenet-2018-105711.

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BackgroundVery long-chain fatty acids (VLCFAs) are essential for functioning of biological membranes. ELOVL fatty acid elongase 1 catalyses elongation of saturated and monounsaturated C22-C26-VLCFAs. We studied two patients with a dominant ELOVL1 mutation. Independently, Kutkowska-Kaźmierczak et al. had investigated the same patients and found the same mutation. We extended our study towards additional biochemical, functional, and therapeutic aspects.MethodsWe did mutation screening by whole exome sequencing. RNA-sequencing was performed in patient and control fibroblasts. Ceramide and sphingo

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Zarrouk, A., T. Nury, J. M. Riedinger, O. Rouaud, M. Hammami, and Gérard Lizard. "Dual effect of docosahexaenoic acid (attenuation or amplification) on C22:0-, C24:0-, and C26:0-Induced mitochondrial dysfunctions and oxidative stress on human neuronal SK-N-BE cells." Journal of nutrition, health & aging 19, no. 2 (2014): 198–205. http://dx.doi.org/10.1007/s12603-014-0518-0.

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Karaman, Maja, Kristina Atlagić, Aleksandra Novaković, et al. "Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms." Antioxidants 8, no. 10 (2019): 480. http://dx.doi.org/10.3390/antiox8100480.

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Compared to plants, nowadays mushrooms attract more attention as functional foods, due to a number of advantages in manipulating them. This study aimed to screen the chemical composition (fatty acids and phenolics) and antioxidant potential (OH•, 2,2-diphenyl-1-picrylhydrazyl (DPPH•) and ferric reducing ability of plasma (FRAP)) of two edible mushrooms, Coprinus comatus and Coprinellus truncorum, collected from nature and submerged cultivation. Partial least square regression analysis has pointed out the importance of some fatty acids—more precisely, unsaturated fatty acids (UFAs) followed by

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Ebisawa, T., K. Tada, I. Kitajima, et al. "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation." Journal of Cell Science 112, no. 20 (1999): 3519–27. http://dx.doi.org/10.1242/jcs.112.20.3519.

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Bone morphogenetic protein (BMP)-6 is a member of the transforming growth factor (TGF)-(β) superfamily, and is most similar to BMP-5, osteogenic protein (OP)-1/BMP-7, and OP-2/BMP-8. In the present study, we characterized the endogenous BMP-6 signaling pathway during osteoblast differentiation. BMP-6 strongly induced alkaline phosphatase (ALP) activity in cells of osteoblast lineage, including C2C12 cells, MC3T3-E1 cells, and ROB-C26 cells. The profile of binding of BMP-6 to type I and type II receptors was similar to that of OP-1/BMP-7 in C2C12 cells and MC3T3-E1 cells; BMP-6 strongly bound t

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Bosson, Régine, Isabelle Guillas, Christine Vionnet, Carole Roubaty, and Andreas Conzelmann. "Incorporation of Ceramides into Saccharomyces cerevisiae Glycosylphosphatidylinositol-Anchored Proteins Can Be Monitored In Vitro." Eukaryotic Cell 8, no. 3 (2008): 306–14. http://dx.doi.org/10.1128/ec.00257-08.

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ABSTRACT After glycosylphosphatidylinositols (GPIs) are added to GPI proteins of Saccharomyces cerevisiae, a fatty acid of the diacylglycerol moiety is exchanged for a C26:0 fatty acid through the subsequent actions of Per1 and Gup1. In most GPI anchors this modified diacylglycerol-based anchor is subsequently transformed into a ceramide-containing anchor, a reaction which requires Cwh43. Here we show that the last step of this GPI anchor lipid remodeling can be monitored in microsomes. The assay uses microsomes from cells that have been grown in the presence of myriocin, a compound that block

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Mărgăoan, Rodica, Marius Zăhan, Liviu A. Mărghitaş, Daniel S. Dezmirean, Silvio Erler, and Otilia Bobiş. "Antiproliferative activity and apoptotic effects of Filipendula ulmaria pollen against C26 mice colon tumour cells." Journal of Apicultural Science 60, no. 1 (2016): 135–44. http://dx.doi.org/10.1515/jas-2016-0014.

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Abstract Honeybee collected pollen exhibits high nutritional and pharmaceutical benefits for the human diet and medicine. Pollen’s antioxidant, anti-ageing, anti-inflammatory, anti-atherosclerosis, and cardioprotective activity, depending on the floral origin, are well known. Recent studies proposed that pollen may also be an excellent cancer-fighting candidate, as pollen harbours high amounts of phenolic substances. In our study, Filipendula ulmaria pollen (bee collected) was methanol-water extracted and used to verify its in vitro pharmacological activities on C26 mice cancer tumour cells. T

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Naito, Masako, Yoshikazu Mikami, Minoru Takagi, and Tomihisa Takahashi. "Up-regulation of Axin2 by dexamethasone promotes adipocyte differentiation in ROB-C26 mesenchymal progenitor cells." Cell and Tissue Research 354, no. 3 (2013): 761–70. http://dx.doi.org/10.1007/s00441-013-1696-5.

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Potara, Monica, Manisha Bawaskar, Timea Simon, et al. "Biosynthesized silver nanoparticles performing as biogenic SERS-nanotags for investigation of C26 colon carcinoma cells." Colloids and Surfaces B: Biointerfaces 133 (September 2015): 296–303. http://dx.doi.org/10.1016/j.colsurfb.2015.06.024.

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Lee, Wan-Chi, Chih-Hsien Chang, Chung-Li Ho, et al. "Early Detection of Tumor Response by FLT/MicroPET Imaging in a C26 Murine Colon Carcinoma Solid Tumor Animal Model." Journal of Biomedicine and Biotechnology 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/535902.

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Fluorine-18 fluorodeoxyglucose (-FDG) positron emission tomography (PET) imaging demonstrated the change of glucose consumption of tumor cells, but problems with specificity and difficulties in early detection of tumor response to chemotherapy have led to the development of new PET tracers. Fluorine-18-fluorothymidine (-FLT) images cellular proliferation by entering the salvage pathway of DNA synthesis. In this study, we evaluate the early response of colon carcinoma to the chemotherapeutic drug, lipo-Dox, in C26 murine colorectal carcinoma-bearing mice by -FDG and -FLT. The male BALB/c mice w

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Luput, Lavinia, Emilia Licarete, Denise Minerva Drotar, et al. "In Vivo Double Targeting of C26 Colon Carcinoma Cells and Microenvironmental Protumor Processes Using Liposomal Simvastatin." Journal of Cancer 9, no. 2 (2018): 440–49. http://dx.doi.org/10.7150/jca.21560.

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Patras, Laura, Alina Sesarman, Emilia Licarete, et al. "Dual role of macrophages in the response of C26 colon carcinoma cells to 5-fluorouracil administration." Oncology Letters 12, no. 2 (2016): 1183–91. http://dx.doi.org/10.3892/ol.2016.4708.

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Morozova, N. B., E. A. Plotnikova, A. D. Plyutinskaya, et al. "Preclinical trial of Bacteriosens used for the photodynamic therapyof malignant tumors, including prostate cancer." Russian Journal of Biotherapy 17, no. 3 (2018): 55–64. http://dx.doi.org/10.17650/1726-9784-2018-17-3-55-64.

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Introduction.Bacteriochlorins are the most promising photosensitizers absorbing in the near-infrared spectral region. Their use can enhance the efficiency of photodynamic therapy due to the deeper penetration of radiation into the tumor.Objectiveto conduct a preclinical study of the photoinduced antitumor activity and biodistribution of Bacteriosens.Materials and methods.Bacteriosens is a preparation based on meso-tetra(3-pyridyl)bacteriochlorin absorbing at 747 nm. Photoinduced cytotoxicity was investigated in vitro using human tumor cells: A549, Hep 2, BT-474, MCF-7, SK-BR-3, PC3, and EJ and

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Kobayashi, Scott D., and Marek M. Nagiec. "Ceramide/Long-Chain Base Phosphate Rheostat in Saccharomyces cerevisiae: Regulation of Ceramide Synthesis by Elo3p and Cka2p." Eukaryotic Cell 2, no. 2 (2003): 284–94. http://dx.doi.org/10.1128/ec.2.2.284-294.2003.

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ABSTRACT Sphingolipid precursors, namely, ceramide and long-chain base phosphates (LCBPs), are important growth regulators with often opposite effects on mammalian cells. A set of enzymes that regulate the levels of these precursors, referred to as a ceramide/LCBP rheostat, is conserved in all eukaryotes. In order to gain further insight into the function of the rheostat in Saccharomyces cerevisiae, we searched for mutants that are synthetically lethal with a deletion of the LCB3 gene encoding LCBP phosphatase. In addition to acquiring expected mutants lacking the LCBP lyase, the screen reveal

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Massart, Isabelle S., Geneviève Paulissen, Audrey Loumaye, et al. "Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia." Cancers 12, no. 11 (2020): 3221. http://dx.doi.org/10.3390/cancers12113221.

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Loss of skeletal muscle mass in cancer cachexia is recognized as a predictor of mortality. This study aimed to characterize the changes in the muscle secretome associated with cancer cachexia to gain a better understanding of the mechanisms involved and to identify secreted proteins which may reflect this wasting process. The changes in the muscle proteome of the C26 model were investigated by label-free proteomic analysis followed by a bioinformatic analysis in order to identify potentially secreted proteins. Multiple reaction monitoring and Western blotting were used to verify the presence o

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Pierron, Alix, Laurence Guzylack-Piriou, Didier Tardieu, Gilles Foucras, and Philippe Guerre. "Zymosan-Induced Murine Peritonitis Is Associated with an Increased Sphingolipid Synthesis without Changing the Long to Very Long Chain Ceramide Ratio." International Journal of Molecular Sciences 24, no. 3 (2023): 2773. http://dx.doi.org/10.3390/ijms24032773.

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Sphingolipids are key molecules in inflammation and defense against pathogens. Their role in dectin-1/TLR2-mediated responses is, however, poorly understood. This study investigated the sphingolipidome in the peritoneal fluid, peritoneal cells, plasma, and spleens of mice after intraperitoneal injection of 0.1 mg zymosan/mouse or PBS as a control. Samples were collected at 2, 4, 8, and 16 h post-injection, using a total of 36 mice. Flow cytometry analysis of peritoneal cells and measurement of IL-6, IL-1β, and TNF-α levels in the peritoneal lavages confirmed zymosan-induced peritonitis. The co

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Naito, Masako, Kazuki Omoteyama, Yoshikazu Mikami, Tomihisa Takahashi та Minoru Takagi. "Inhibition of Wnt/β-catenin signaling by dexamethasone promotes adipocyte differentiation in mesenchymal progenitor cells, ROB-C26". Histochemistry and Cell Biology 138, № 6 (2012): 833–45. http://dx.doi.org/10.1007/s00418-012-1007-3.

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