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Дисертації з теми "Calcification"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Harper, Glenn Martin. "Calcification in coccolithophores." Thesis, University of Plymouth, 2017. http://hdl.handle.net/10026.1/8664.

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Coccolithophores are uni-cellular phytoplankton and they form an exceedingly diverse group in the phylum Haptophyta. They produce highly complex structures known as coccoliths by a biomineralisation process known as calcification. The first part of the work undertaken was to investigate the process of calcification in the coccolithophore Coccolithus pelagicus using a combination of Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and light microscopy techniques. This allowed better understanding of the formation, transit of the coccolith through the cell until its fin

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2

Desjardins, Lucie. "Marqueurs de risque des complications de la maladie rénale chronique." Thesis, Amiens, 2015. http://www.theses.fr/2015AMIE0013.

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La maladie rénale chronique (MRC) est un problème majeur de santé publique du fait de l’augmentation constante de son incidence et des complications cardiovasculaires fréquemment rencontrées, de même que l’accumulation dans le sang des patients de molécules appelées toxines urémiques. Le but de cette thèse est de déterminer les potentielles associations entre certaines toxines urémiques et certaines techniques non-invasives avec les paramètres biochimiques et vasculaires, la mortalité globale et cardiovasculaire dans une cohorte de patients à différents stades de la MRC. Dans cette étude, nous

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3

Byon, Chang Hyun. "Oxidative stress-stimulated vascular calcification." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2009. https://www.mhsl.uab.edu/dt/2010r/byon.pdf.

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4

Dhore, Cherida Rachel. "Molecular regulation of vascular calcification." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 2005. http://arno.unimaas.nl/show.cgi?fid=6374.

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5

Walker, Charlotte. "Mechanisms of calcification in coccolithophores." Thesis, University of Southampton, 2018. https://eprints.soton.ac.uk/425508/.

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Анотація:

Coccolithophores are unicellular marine algae characterised by the production of calcite coccoliths. As a result of their calcification they contribute significantly to global biogeochemical cycles. Comprehensive understanding of the mechanisms behind calcification remains elusive, due in part to the research focus on one species, Emiliania huxleyi; the most globally abundant of all coccolithophores. It is imperative to investigate calcification in other species to better understand this biogeochemically important process, especially as the ecological success of E. huxleyi may be due to certai

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6

Pawade, Tania Ashwinikumar. "Imaging calcification in aortic stenosis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/29589.

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BACKGROUND Aortic stenosis is a common and potentially fatal condition in which fibro-calcific changes within the valve leaflets lead to the obstruction of blood flow. Severe symptomatic stenosis is an indication for aortic valve replacement and timely referral is essential to prevent adverse clinical events. Calcification is believed to represent the central process driving disease progression. 18F-Fluoride positron emission tomography computed tomography (PET-CT) and CT aortic valve calcium scoring (CT-AVC) quantify calcification activity and burden respectively. The overarching aim of this

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7

Zainuddin. "Synthesis and calcification of hydrogel biomaterials /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18693.pdf.

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8

Chau, Hien Nguyet 1977. "Renal calcification in Npt2 knockout mice." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=78338.

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Mice homozygous for the disrupted renal type 11a sodium/phosphate (Na/Pi) cotransporter gene, Npt2, (Npt2 KO) exhibit renal Pi wasting and hypercalciuria, predisposing factors for renal stone formation. We observed that Npt2 KO mice, but not wild-type littermates form renal stones. The renal stones were evident in newborn, weanling and adult mice and composed of calcium (Ca) and Pi. The presence of renal calcification correlated with the absence of Npt2 gene expression and the presence of genes responsible for the synthesis (1alpha-hydroxylase) and catabolism (24-hydroxylase) of 1,25-di

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9

Rendeiro, Ana Rita Pimentel do Couto. "Genetics and epidemiology of ectopic calcification." Doctoral thesis, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/54257.

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10

Promsy, Eric. "Calcification du disque intervertébral chez l'enfant." Montpellier 1, 1988. http://www.theses.fr/1988MON11212.

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11

Zhang, Yinxing. "Bioprosthetic heart valves : ultrastructure and calcification." Master's thesis, University of Cape Town, 1998. http://hdl.handle.net/11427/26921.

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Анотація:

Sumaary in English.<br>Includes bibliographical references.<br>Background: Due to the geographic distance between abattoirs and commercial valve plants delays between harvest and fixation usually range from 48 to 72 hours. In order to assess the pre-fixation tissue damage arising from the hypoxic period and the resulting calcific degeneration after implantation, we used an ultrastructural damage score and transmission electron microscopy. Materials and Methods: In a step by step manner, three major issues were clarified: 1) The degree of pre-fixation tissue damage was determined in the four mo

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12

Morony, Sean Edward. "Regulation of vascular calcification by osteoprotegerin." Diss., Restricted to subscribing institutions, 2007. http://proquest.umi.com/pqdweb?did=1472152041&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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13

Rendeiro, Ana Rita Pimentel do Couto. "Genetics and epidemiology of ectopic calcification." Tese, Instituto de Ciências Biomédicas Abel Salazar, 2008. http://hdl.handle.net/10216/54257.

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14

Bouderlique, Élise. "ABCC6 et biominéralisation rénale et vasculaire." Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS557.

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Анотація:

La survenue de calcifications ectopiques est un problème majeur de santé publique. Les calculs rénaux notamment affectent 10 % de la population générale et peuvent avoir de multiples complications pouvant aller jusqu’à l’insuffisance rénale chronique terminale. Les calculs de type « oxalo-calciques » sont les plus fréquents. Ils sont souvent générés sur des plaques de Randall, des calcifications interstitielles papillaires faites de phosphate de calcium (apatite). Au cours des dernières décennies, une augmentation importante de la prévalence de ces calculs a été observée chez les jeunes adulte

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15

Hristova, Gergana. "Calcification in Intervertebral Disc Degeneration and Scoliosis." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86948.

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In degenerative and scoliotic intervertebral discs (IVD), calcification is a pathological process that may lead to impairment of the nutrient supply and a disturbance in disc metabolism. However, the process of calcification in disc degeneration and scoliosis is not well understood. The purpose of this study was to assess the calcification markers in IVD of patients with degenerative disc disease and adolescent idiopathic scoliosis. For this purpose, 34 IVDs from 16 adult patients with degenerative disc disease and 25 IVDs from 9 adolescent patients with adolescent idiopathic scoliosis were ob

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16

Berry, L. S. "Calcification, photosynthesis and nutrient uptake in coccolithophores." Thesis, Swansea University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.636084.

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<I>Emiliania huxleyi</I> is the most abundant coccolithophore in the World's oceans today. These organisms have the ability to calcify and photosynthesise, and may represent an important oceanic sink for dissolved inorganic carbon. As a result, they have the potential to influence the oceanic carbon cycle. It has been proposed that calcification may improve carbon acquisition under CO<SUB>2</SUB> <SUB>(aqueous)</SUB> limiting conditions, but may involve high Ca<SUP>2+</SUP> transport costs. In this thesis, results presented show that calcification increases in <I>E. huxleyi</I> (strain L) in r

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17

Yarra, Tejaswi. "Transcriptional profiling of shell calcification in bivalves." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31408.

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Анотація:

Mollusc shells are unique adaptations that serve to protect the organisms that make them, and are a defining feature of the phylum. However the molecular underpinnings of shell forming processes are still largely unexplored. To further understand mollusc shell formation, I studied three bivalve species in this project: the blue mussel Mytilus edulis, the Pacific oyster Crassostrea gigas, and the king scallop Pecten maximus. While previous analyses of the shell proteomes showed species specificity, transcriptomes of the mantle tissues revealed more commonalities. To reconcile these differences,

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18

Ponnusamy, Arvind. "The role of prenylation in vascular calcification." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-prenylation-in-vascular-calcification(421c189b-8c72-4a92-bdc7-85d433699c4c).html.

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Vascular calcification is an active, regulated process in which vascular smooth muscle cells (VSMCs) differentiate into osteoblast-like cells and deposit a mineralised matrix. It is well established that patients with chronic kidney disease and diabetes have poor cardiovascular outcomes which is thought to be due to increased vascular calcification and atherosclerosis. Previous work from the host laboratory has shown that nitrogen-containing bisphosphonates attenuate vascular calcification by inhibiting farnesyl pyrophosphate synthase, depleting cells of farnesyl pyrophosphate and geranylgeran

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19

Skafi, Najwa. "Role of Phospholipase D in Vascular Calcification." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1339/document.

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La calcification vasculaire est l’accumulation de cristaux de calcium dans les vaisseaux sanguins à travers un processus pathologique qui ressemble à la formation de l’os ou du cartilage. Elle apparaît notamment chez les patients diabétiques ou atteints d’une insuffisance rénale chronique. La conséquence principale de la calcification vasculaire est la perte de l’élasticité qui est indispensable pour la fonction des larges artères, elle est de plus associée à la mortalité des patients hémodialysés. Les traitements contre la calcification vasculaire sont généralement limités à ceux qui corrigen

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20

Ludwig, Rebecca. "Carbon cycling and calcification in hypersaline microbial mats." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=979757312.

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21

Osman, Lana. "Cellular and Molecular Mechanisms of Aortic Valve Calcification." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490945.

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Aortic valve calcification is an active inflammatory condition characterised by thickening and calcification of the leaflets. The cellular and molecular mechanisms of the disease are unknown. We hypothesised that valve interstitial cells (lCs) playa key role in the calcification process by acting as a target for inflammatory cytokines that are involved in initiating signalling cascades to promote osteogenic differentiation of the cells, a mechanism that could be manipulated phannacologically. Calcified human aortic valve leaflets were characterised with the presence of calcium nodules and bone

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22

Fröhner, Michael, Oliver W. Hakenberg, Andreas Manseck, Sven Oehlschläger, and Manfred P. Wirth. "Unusual Semi-Spheric Perivesical Calcification after Pelvic Radiotherapy." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133912.

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An uncommon case with semi-spheric perivesical calcification after pelvic radiotherapy is reported and the possible pathogenesis of this phenomenon is discussed<br>Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich

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23

Mohamed, Moinuddin Mohammed. "Characterisation of peritoneal calcification in encapsulating peritoneal sclerosis." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/characterisation-of-peritoneal-calcification-in-encapsulating-peritoneal-sclerosis(003593cd-01f0-4e7b-a22b-d216451f6a93).html.

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Encapsulating peritoneal sclerosis (EPS) is a rare complication of long-term peritoneal dialysis (PD). EPS is associated with extensive thickening and fibrosis of the peritoneum resulting in the formation of a fibrous cocoon encapsulating the bowel leading to intestinal obstruction. The presence of peritoneal thickening, peritoneal calcification and bowel obstruction is considered to be diagnostic of EPS. The current understanding of the pathogenesis of EPS is through the 'two-hit' fibrosis model. This model, however, does not explain the development of peritoneal calcification in patients wit

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24

Zhu, Dongxing. "Role of osteocyte markers in medial vascular calcification." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8765.

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Анотація:

Vascular calcification is prevalent in ageing, in atherosclerosis, and especially in patients with Chronic Kidney Disease (CKD), with associated increased morbidity and mortality. The phenotypic transition of Vascular Smooth Muscle Cells (VSMCs) into osteoblastic/chondrogenic-like cells is critical for the development of calcification in CKD patients. Osteocytes, terminally differentiated osteoblasts, have recently emerged as major regulators of calcification in bone. Recently, osteocytelike cells have been observed in human peripheral arteries with medial vascular calcification. However, it r

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25

Fröhner, Michael, Oliver W. Hakenberg, Andreas Manseck, Sven Oehlschläger, and Manfred P. Wirth. "Unusual Semi-Spheric Perivesical Calcification after Pelvic Radiotherapy." Karger, 1999. https://tud.qucosa.de/id/qucosa%3A27548.

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Анотація:

An uncommon case with semi-spheric perivesical calcification after pelvic radiotherapy is reported and the possible pathogenesis of this phenomenon is discussed.<br>Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.

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26

Morris, Thomas. "The role of bioactive sphingolipids in vascular calcification." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-bioactive-sphingolipids-in-vascular-calcification(5235985a-0992-432e-9df2-35519725f87a).html.

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Vascular calcification is the formation of mineralised tissue within the walls of arteries. The pathology has many similarities to embryonic bone formation and involves the osteogenic differentiation of vascular smooth muscle cells (VSMCs) and matrix mineralisation. Recent studies have demonstrated that the bioactive sphingolipids, ceramide and sphingosine-1-phosphate (S1P), regulate embryonic bone formation. Ceramide can be generated by lysosomal acid sphingomyelinase (L-SMase) and neutral sphingomyelinase (N-SMase), and be converted to sphingosine by acid ceramidase (ACDase) and subsequently

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27

Todd, Alexandra Frances. "The role of angiopoietin-2 in vascular calcification." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10044744/.

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Анотація:

Cardiovascular disease (CVD) is a leading cause of mortality in paediatric patients with chronic kidney disease (CKD), particularly in those undergoing dialysis. One of the earliest events in CVD is endothelial damage, which may result from changes in levels of vascular growth factors that control blood vessel function and stability. Markers of endothelial dysfunction and vascular calcification are observed during CKD, and are documented as early as the first decade of life. Previous research indicates that growth factors controlling blood vessel function and stability are altered in CKD patie

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28

MANCINELLI, LUIGI. "Role of HMGB1 in vascular aging and calcification." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1301313.

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BACKGROUND- Vascular calcification (VC) is an age-associated complication of cardiovascular diseases, in which the main cellular event is the trans-differentiation of vascular smooth muscle cells (VSMCs) from a contractile to an osteochondrogenic phenotype that leads to an accumulation of calcium deposits. Senescence facilitates VSMCs osteogenic transition. VC is strongly associated with inflammation, oxidative stress and high level of DNA damage. HMGB1 is a highly conserved non-histone chromatin binding protein involved in transcription, DNA repair, and maintenance of nucleosome structure tha

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29

Moya, Aurélie. "Approches physiologique et moléculaire de la calcification et de la "light-enhanced calcification" chez le corail Scléractiniaire Stylophora pistillata (Esper, 1797)." Aix-Marseille 2, 2007. http://theses.univ-amu.fr.lama.univ-amu.fr/2007AIX22073.pdf.

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Les récifs coralliens, majoritairement édifiés par les coraux Scléractiniaires, constituent la plus importante construction biologique à l’échelle mondiale. De nombreux coraux Scléractiniaires établissent une symbiose avec un Dinobionte photosynthétique. Cette symbiose est responsable, entre autres, d’une stimulation de la calcification des coraux en présence de lumière, phénomène décrit sous le terme de “light-enhanced calcification” (LEC). Malgré de nombreuses recherches, les mécanismes responsables de ce phénomène de LEC restent méconnus. Ma thèse a consisté en l’étude de la calcification e

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30

Varennes, Olivier. "Le rôle de l'Epoxyde hydrolase soluble (sEH) dans la physiopathologie des calcifications vasculaires." Electronic Thesis or Diss., Amiens, 2018. http://www.theses.fr/2018AMIE0046.

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L'Epoxide Hydrolase soluble (sEH) est une enzyme exprimée dans les vaisseaux. Elle possède un domaine hydrolase à l'extrémité COOH-term (sEH-H) qui métabolise des facteurs vasodilatateurs et anti-inflammatoires comme les acides époxyeicosatriénoïques (EETs). Elle possède également un domaine phosphatase à l'extrémité NH2-term (sEH-P) dont le rôle biologique n'est pas totalement élucidé. Afin de comprendre le rôle de sEH-H et sEH-P dans la calcification vasculaire, des anneaux aortiques de rats et des cellules musculaires lisses vasculaires humaines (CMLVh) ont été exposés à des conditions proc

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31

Boroomand, Seti. "Valvular interstitial cell transformation : implications for aortic valve calcification." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/47138.

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Aortic valve stenosis (AVS) involves the transformation of valvular interstitial cells (VIC) into an osteoblastic phenotype. Such valvular disease is mostly associated with both thickening and calcification of the valve cusps, which is accompanied by inflammation and remodeling of the tissue. This process is mediated by the VIC that carry out an impressive array of functions throughout the calcification process. For this dissertation, I hypothesized that in AVS, VIC transform from a myofibroblast phenotype to osteoblast-like cells and that the canonical Wnt and TGFβ pathways and vitamin D3 int

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32

Abu-Mansour, Filimban Waheed. "Calcification in diseases of breast: ultrastructural and histological studies." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493438.

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33

Reynolds, Joanne Lesley. "Mechanisms and regulation of vascular smooth muscle cell calcification." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619743.

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34

Sim, Alisia Mara. "Detection of calcification in atherosclerotic plaques using optical imaging." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33151.

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Анотація:

PET imaging, using the bone tracer Na18F, allows the non-invasive location of atherosclerotic plaques that are at risk of rupture. However, the spatial resolution of PET is only 4-5 mm, limiting the mechanistic information this technique can provide. In this thesis, the use of fluorescence and Raman imaging to elucidate the mechanism of micro-calcification within atherosclerotic plaques has been investigated. A number of fluorescent probes to detect fluoride and calcium have been synthesised. One of the fluoride probes has been shown to be selective for fluoride however, the concentration of f

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35

Ghatora, Baljit. "Investigation into the calcification and aging of intraocular lenses." Thesis, Kingston University, 2010. http://eprints.kingston.ac.uk/35856/.

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Анотація:

Poly (methyl methacrylate) (PMMA) has been the preferred biocompatible biomaterial for use in intraocular lenses (IOLs) since 1949, when its optical benefits were discovered by Harold Ridley. Calcification of intraocular lenses is an area that is not addressed adequately in literature, but is a problem that requires repeat surgery, which is not usually an option in third world countries. Calcification is a setback to IOLs that needs to be further studied so that possible solutions can be found. The effects of sterilisation and incubation in an extreme calcific environment, namely a metastable

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36

Kieffer, Pascal. "Calcification de la paroi artérielle : modèles, conséquences et mécanismes." Nancy 1, 2000. http://www.theses.fr/2000NAN12011.

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Thèse de doctorat en sciences du médicament. La calcification de la paroi artérielle au cours du vieillissement peut conduire à la survenue de l'artériosclérose et de l'athérome, qui représentent deux des trois plus importantes pathologies responsables de l'augmentation de morbidité et mortalité cardio-vasculaires dans la population occidentale vieillissante. L'étude des processus de calcification artérielle et de leurs conséquences permettrait d'identifier de nouvelles cible thérapeutiques de l'artériosclérose et de l'athérome. Nous avons étudié le phénomène d'artériosclérose dans différents

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37

Woldt, Estelle. "Implication de LRP1 dans l’athérosclérose et la calcification vasculaire." Strasbourg, 2009. https://publication-theses.unistra.fr/public/theses_doctorat/2009/WOLDT_Estelle_2009.pdf.

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La calcification vasculaire est une complication de l'athérosclérose, cependant les mécanismes moléculaires de ce processus sont encore inconnus. Nous avons constaté que PPARγ et LRP1 interagissent fonctionnellement pour contrôler la transformation des cellules musculaires lisse (CML) en cellules cartilagineuses. L’inactivation de LRP1 dans le muscle lisse perturbe l’export du cholestérol et accélère la formation de la plaque d’athérome, cet effet est atténué par la rosiglitazone, un agoniste de PPARγ. L’inactivation de l’expression de PPARγ dans les CML induit la formation de cartilage dans l

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38

Blue, Christina R. "Establishing the Physical Basis for Calcification by Amorphous Pathways." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/48167.

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The scientific community is undergoing a paradigm shift with the realization that the formation of carbonate minerals with diverse compositions and textures can be understood within the framework of multiple pathways to mineralization. A variety of common minerals can form via an amorphous pathway, where molecules or clusters aggregate to form a metastable amorphous phase that later transforms to one or more crystalline polymorphs. Amorphous calcium carbonate (ACC) is now recognized in a wide variety of natural environments. Recent studies indicate the chemical signatures and properties of the

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39

Young, Melissa Denton. "Arterial Calcification and the Clinical Implications on Stent Function." Case Western Reserve University School of Graduate Studies / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=case1364999090.

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40

Furmanik, Malgorzata. "The role of endoplasmic reticulum stress in vascular calcification." Thesis, King's College London (University of London), 2015. http://kclpure.kcl.ac.uk/portal/en/theses/the-role-of-endoplasmic-reticulum-stress-in-vascular-calcification(a0138614-e3d8-42ef-9cbf-02a01f6e6eaf).html.

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Vascular calcification (VC) is a health problem common in ageing populations, diabetes and chronic kidney disease. It leads to vascular stiffening and heart failure. VC is a regulated process mediated by vascular smooth muscle cells (VSMCs), with similarities to developmental osteogenesis. The exact molecular events responsible for triggering it are unknown. The endoplasmic reticulum (ER) is involved in folding of proteins. ER stress occurs as a result of unfolded protein accumulation and has been implicated in osteoblast differentiation and bone mineralization. Therefore, I hypothesized that

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41

Webb, Jason. "Growth, calcification and photosynthesis in the coccolithophorid chrysotila carterae." Thesis, Webb, Jason (2015) Growth, calcification and photosynthesis in the coccolithophorid chrysotila carterae. PhD thesis, Murdoch University, 2015. https://researchrepository.murdoch.edu.au/id/eprint/30271/.

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The mass culture of microalgae for the commercial production of a) low value commodities such as biofuel and food and b) high value products such as polyunsaturated fatty acids, carotenoids, and nano-scaffolds is becoming increasingly attractive. Coccolithophorid algae have been investigated as potential candidates for both low and high value products. This thesis provides data on the specific nutrient and growth requirements in the coccolithophorid, Chrysotila carterae (previously Pleurochrysis carterae). Via the use of oxygen evolution techniques and PAM fluorometry, it is shown that C. cart

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Rattazzi, Marcello. "Contribution of Interstitial Valve Cells to Aortic Valve Calcification." Doctoral thesis, Università degli studi di Padova, 2009. http://hdl.handle.net/11577/3425639.

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Background. The traditional view of aortic valve calcification as a slow, ineluctable event has been recently questioned by evidence showing the importance of a balance between promoting and inhibiting factors, and the relevance of osteogenic cellular-driven processes. The aortic valve leaflets are comprised of a heterogeneous population of interstitial cells (VIC) whose specific contribution to the degenerating valve has not been defined yet. Aim. The major aim is to identify and describe the phenotypic characteristics of a subpopulation of aortic VIC able to acquire a pro-calcific profile

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Akodad, Mariama. "Marqueurs pronostiques biologiques et morphologiques du TAVI à l’ère de l’évolution des pratiques." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT061.

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La prise en charge du rétrécissement aortique a connu une véritable révolution avec l’avènement du remplacement valvulaire aortique percutané (TAVI). Cette technique, s’adressant initialement à des patients à haut risque chirurgical, a été étendue à des patients à moindre risque du fait de l’amélioration des résultats et s’est accompagnée, au fil des années, d’une simplification de la procédure. Cependant, la sélection rigoureuse des patients en amont de la procédure reste la clé du succès de cette technique. Les facteurs cliniques et échographiques sont insuffisants pour permettre une évaluat

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Herfort, Lydie Marie-Claude Catherine. "Photosynthesis and calcification in the coccolithophore, Emiliania huxleyi, and two hermatypic corals, Porites porites and Acropora sp." Thesis, Queen Mary, University of London, 2002. http://qmro.qmul.ac.uk/xmlui/handle/123456789/28588.

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Most global calcification is carried out by organisms which are also photosynthetic. In this study, the coccolithophore Emiliania huxleyi (Lohmann) Hay and Mohler and two species of hermatypic coral were used to: examine the effect of dissolved inorganic carbon (DIC) and light on photosynthesis and calcification; and determine the extent to which these two processes interact. A novel method of producing coccolith-less (non-calcifying) cells from calcifying cells of the same strain of E huxley! was developed thus allowing photosynthesis and calcification to be studied separately. The kinetics o

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Rosa, Mickael. "Athérosclérose et sténose valvulaire aortique : implication des macrophages et des cellules interstitielles de valve dans les calcifications cardiovasculaires." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S046.

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Les pathologies cardiovasculaires sont le plus souvent l’aboutissement des processus liés à l’athérosclérose. Elles représentent la première cause de morbi-mortalité dans le monde et leur incidence s’accroit avec le vieillissement de la population et l’expansion de facteurs de risques comme le diabète ou l’obésité. La sténose valvulaire aortique (SVA) est la valvulopathie la plus fréquente dans les pays développés présentant de nombreux points communs avec l’athérosclérose vasculaire. En plus des facteurs de risque, les lésions valvulaires et les lésions vasculaires partagent des similitudes d

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Després, Audrey-Anne, and Audrey-Anne Després. "Lipoprotéine(a) et microcalcification de la valve aortique." Master's thesis, Université Laval, 2020. http://hdl.handle.net/20.500.11794/38301.

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La sténose aortique (SA) est la maladie valvulaire la plus fréquente dans notre société. Elle est caractérisée par un remodelage fibrocalcique conduisant à une obstruction progressive du flux sanguin. La lipoprotéine(a) (Lp[a]), une lipoprotéine similaire à la lipoprotéine de faible densité, est un facteur de risque génétique fortement associé à la SA. Malheureusement, les concentrations plasmatiques de Lp(a) sont très peu influencées par des facteurs extrinsèques, tels qu’un régime alimentaire ou une médication hypolipidémiante. Des études suggèrent que la Lp(a) serait associée aux processus

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De, Bodt Caroline. "Pelagic calcification and fate of carbonate production in marine systems." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210156.

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Human activities have contributed to the increase in atmospheric greenhouse gases such as carbon dioxide (CO2). This anthropogenic gas emission has led to a rise in the average Earth temperature. Moreover, the ocean constitutes the major sink for anthropogenic CO2 and its dissolution in surface waters has already resulted in an increase of seawater acidity since the beginning of the industrial revolution. This is commonly called ocean acidification. The increase in water temperature could induce modifications of the physical and chemical characteristics of the ocean. Also, the structure and th

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Dubois, Philippe. "Tissu squelettique et calcification chez Asterias rubens L.(Echinodermata: Asteroidea)." Doctoral thesis, Universite Libre de Bruxelles, 1988. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213314.

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Jie, Gerard Kon Siong. "The role of vitamin K-dependent proteins in tissue calcification." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=8340.

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Cirka, Heather Ann. "Mechanical Regulation of Apoptosis and Calcification within Valvular Interstitial Cells." Digital WPI, 2016. https://digitalcommons.wpi.edu/etd-dissertations/213.

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Calcific aortic valvular disease (CAVD) is the most common valvular pathology in the developed world. CAVD results in calcifications forming on the aortic valve leaflets, inhibiting proper closure and causing complications of stenosis and regurgitation. Although, the mechanisms behind the disease initiation are unknown, it is believed to be a cell-mediated phenomenon, and not the result of passive degradation of the valve as once believed due to the increased prevalence with age. Currently, there are no pharmaceutical options for the prevention or reversal of calcifications, the only treatment

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