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Дисертації з теми "Cell adhesion"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Stewart, Alasdair Gwilym. "Studies of focal adhesion kinase in epithelial cells : involvement in cell-cell adhesion." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1446839/.

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Epithelial cell-cell adhesion is mediated by tight junctions, adherens junctions and desmosomes. Epithelial cell-matrix adhesion is mediated by hemidesmosomes and focal contacts. These complexes exhibit great plasticity, and each contains molecular components which are able to participate in one or more of the other adhesive complexes. Focal adhesion kinase (FAK/pl25FAK) is a non-receptor tyrosine kinase which transduces signals from integrins at sites of focal contact to promote adhesion, spreading and migration. FAK possesses a central kinase domain which is flanked by large, non-catalytic,

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2

Armstrong, Nicola J. "Continuum modelling of cell-cell adhesion." Thesis, Heriot-Watt University, 2008. http://hdl.handle.net/10399/2167.

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Cells adhere to each other through the binding of cell adhesion molecules at the cell surface. This process, known as cell-cell adhesion, is fundamental in many areas of biology, including early embryo development, tissue homeostasis and tumour growth. Here \~e present a new continuum mathematical model of this phenomenon by considering Ã‚Â· the movement of cells in response to the adhesive forces generated through binding. We demonstrate that the model predicts aggregative behaviour, characteristic of an adhesive cell population. Further, when extended to two cell populations, the model predi

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3

Muniz, Maisonet Maritza. "Topographical Enhancement of Cell Adhesion on Poorly Adhesive Materials." Scholar Commons, 2015. https://scholarcommons.usf.edu/etd/5748.

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The overall thrust of this dissertation is to gain a fundamental understanding of the synergistic effects between surface topography and chemical functionality of poorly adhesive materials on enhancing the adhesion of mouse embryonic fibroblasts. Cellular response to surface topography and chemical functionality have been extensively studied on their own providing valuable information that helps in the design of new and improved biomaterials for tissue engineering applications. However, there is a lack of understanding of the synergistic effect of microscale and nanoscale topography with chemi

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4

Maghzal, Nadim. "The epithelial cell adhesion molecule (EpCAM) regulates cell motility and cell-cell adhesion by inhibiting PKC signaling." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=114215.

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Tissue cohesion is achieved in part by a large family of plasma membrane-bound cell adhesion molecules (CAMs). During morphogenesis, CAM-mediated interactions provide adhesive forces required for cells to aggregate and form tissues. CAM-mediated adhesions in developing cells are highly dynamic, which provides the fluidity required for cellular movements that drive morphogenesis. Xenopus laevis gastrulation is an established model to study morphogenetic movements. During this phase of development, the mesoderm moves inside the embryo through involution, and migrates along the inner surface of t

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5

Théard, Delphine Francine. "P27Kip1 in cell-cell adhesion and cell polarity." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2006. http://irs.ub.rug.nl/ppn/291442056.

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6

Dix, Christina Lyn. "Adhesion-dependent cell division." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10044469/.

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Animal cells undergo a dramatic series of cell shape changes as they pass through mitosis and divide which depend both on remodelling of the contrac- tile actomyosin cortex and on the release of cell-substrate adhesions. Here, I use the adherent, non-transformed, human RPE1 cell line as a model system in which to explore the dynamics of these shape changes, and the function of mitotic adhesion remodelling. Although these cells are highly motile, and therefore polarised in interphase, many pause migration and elongate to be- come bipolar prior to mitosis. Interestingly, and in contrast to most

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7

Pouliot, Yannick 1963. "Study of L6 myoblast cell-cell adhesion." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61797.

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8

Betson, Martha Elizabeth. "Regulation of cell-cell adhesion in keratinocyes." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274930.

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9

Zhao, Lee Cheng. "Cell adhesion characterization of adhesive forces and effect of topography /." [Gainesville, Fla.] : University of Florida, 2000. http://etd.fcla.edu/etd/uf/2000/ana7043/LCZhao%5FThesis.pdf.

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Анотація:

Thesis (M.S.)--University of Florida, 2000.<br>Title from first page of PDF file. Document formatted into pages; contains ix, 79 p.; also contains graphics. Vita. Includes bibliographical references (p. 69-77).

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10

Elineni, Kranthi Kumar. "Regulation of Cell Adhesion Strength by Spatial Organization of Focal Adhesions." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3088.

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Анотація:

Cell adhesion to extracellular matrix (ECM) is critical to various cellular processes like cell spreading, migration, growth and apoptosis. At the tissue level, cell adhesion is important in the pathological and physiological processes that regulate the tissue morphogenesis. Cell adhesion to the ECM is primarily mediated by the integrin family of receptors. The receptors that are recruited to the surface are reinforced by structural and signaling proteins at the adhesive sites forming focal adhesions that connect the cytoskeleton to further stabilize the adhesions. The functional roles of thes

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11

Burthem, John. "Hairy cell adhesion and migration." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240394.

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12

Yildirim, Ali. "Measurement of cultured cell adhesion." Thesis, University of Bath, 1994. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760660.

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13

Sarwar, Muhammad. "Measurement of mammalian cell adhesion." Thesis, University of Bath, 1992. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314527.

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14

Krieg, Michael. "Cell adhesion and cell mechanics during zebrafish development." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-26093.

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Анотація:

During vertebrate development, gastrulation leads to the formation of three distinct germlayers. In zebrafish a central process is the delamination and the ingression of single cells from a common ancestor tissue - that will lead to the formation of the germlayers. Several molecules have been identified to regulate this process but the precise cellular mechanisms are poorly understood. Differential adhesiveness, a concept first introduced by Steinberg over 40 years ago, has been proposed to represent a key phenomena by which single hypoblast cells separate from the epiblast to form the mesendo

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15

Krieg, Michael. "Cell adhesion and cell mechanics during zebrafish development." Doctoral thesis, Technische Universität Dresden, 2009. https://tud.qucosa.de/id/qucosa%3A25182.

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Анотація:

During vertebrate development, gastrulation leads to the formation of three distinct germlayers. In zebrafish a central process is the delamination and the ingression of single cells from a common ancestor tissue - that will lead to the formation of the germlayers. Several molecules have been identified to regulate this process but the precise cellular mechanisms are poorly understood. Differential adhesiveness, a concept first introduced by Steinberg over 40 years ago, has been proposed to represent a key phenomena by which single hypoblast cells separate from the epiblast to form the mesendo

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16

Amin, Bakr. "Dynamics of E-cadherin mediated cell-cell adhesion." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21122.

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Анотація:

Thesis (M.A.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>In epithelial cells, formation of stable adherens junction is essential for a number of important cell processes. The central protein responsible for creating cell-cell adhesion is known as E-cadherin. When the lamellipodia of migr

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17

Hadjisavas, Michael. "Induction of mitogenesis and cell-cell adhesion by porcine seminal plasma." Title page, contents and abstract only, 1992. http://web4.library.adelaide.edu.au/theses/09PH/09phh1293.pdf.

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Includes list of publications by the author. Includes bibliographical references (leaves 103-123) Evaluates the nature of the interactions occurring between semen and cells of the uterus that occur following mating in pigs. Describes a novel ability of porcine seminal plasma to induce dose dependent cell-cell adhesion and mitogenesis amongst peripheral blood lymphocytes in vitro.

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18

Pearce, Kristen (Kristen Joanne) 1974. "Regulation of adhesion between round spermatids and Sertoli cells in the testis." Monash University, Dept. of Obstetrics and Gynaecology, 2003. http://arrow.monash.edu.au/hdl/1959.1/6606.

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19

Miyahara, Ryo. "Expression of neural cell adhesion molecules(polysialated form of neural cell adhesion molecule and L1-cell adhesion molecule)on resected small cell lung cancer specimens : in relation to proliferation state." Kyoto University, 2001. http://hdl.handle.net/2433/150163.

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20

Coyer, Sean R. "Modulation of cell adhesion strengthening by nanoscale geometries at the adhesive interface." Diss., Georgia Institute of Technology, 2010. http://hdl.handle.net/1853/34763.

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Анотація:

Cell adhesion to extracellular matrices (ECM) is critical to many cellular processes including differentiation, proliferation, migration, and apoptosis. Alterations in adhesive mechanisms are central to the behavior of cells in pathological conditions including cancer, atherosclerosis, and defects in wound healing. Although significant progress has been made in identifying molecules involved in adhesion, the mechanisms that dictate the generation of strong adhesive forces remain poorly understood. Specifically, the role of nanoscale geometry of the adhesive interface in integrin recruitment an

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21

Schwarz, Ulrich. "Forces and elasticity in cell adhesion." [S.l. : s.n.], 2004. http://pub.ub.uni-potsdam.de/2004/0034/schwarz.pdf.

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22

Schwarz, Ulrich Sebastian. "Forces and elasticity in cell adhesion." Thesis, Universität Potsdam, 2004. http://opus.kobv.de/ubp/volltexte/2005/110/.

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Анотація:

Das Verhalten adhärenter Zellen hängt stark von den chemischen, topographischen und mechanischen Eigenschaften ihrer Umgebung ab. Experimentelle Untersuchungen der letzten Jahre haben gezeigt, dass adhärente Zellen aktiv die elastischen Eigenschaften ihrer Umgebung erkunden, indem sie an dieser ziehen. Der resultierende Kraftaufbau hängt von den elastischen Eigenschaften der Umgebung ab und wird an den Adhäsionskontakten in entsprechende biochemische Signale umgewandelt, die zelluläre Programme wie Wachstum, Differenzierung, programmierten Zelltod und Zellbewegung mitbestimmen. Im Allgemeinen

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23

McClure, Diane. "Cell adhesion mechanisms in colon cancer." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=57005.

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Cell adhesion molecules are thought to have an important role in neoplastic progression as they are likely to be involved in the multiple steps of the metastatic cascade. We have focused on two adhesion molecules, E-cadherin and CD44, looking for changes in their expression in human colon cancer. The intercellular adhesion mediated by E-cadherin has been shown to be altered in cancer. We have investigated the expression of E-cadherin in normal and tumorigenic colorectal mucosa by immunohistochemistry. Tumor samples showed a down-regulation of expression correlating with the degree of tumor ded

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24

May, Andrew Paul. "Structural studies on cell adhesion molecules." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298346.

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25

Wright, Karen. "Synthesis of oligosaccharides affecting cell adhesion." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267483.

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26

Minett, William T. "Cell adhesion on synthetic polymer substrates." Thesis, Aston University, 1986. http://publications.aston.ac.uk/14512/.

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27

Kang, Youn-Jung. "Cell adhesion and signalling at implantation." Thesis, University of Oxford, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711653.

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28

Welf, Erik Steven. "Integrative modeling of cell adhesion processes." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 285 p, 2009. http://proquest.umi.com/pqdweb?did=1833641671&sid=4&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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Thesis (Ph.D.)--University of Delaware, 2009.<br>Principal faculty advisors: Babatunde Ogunnaike, Dept. of Chemical Engineering, and Ulhas P. Naik, Dept. of Biological Sciences. Includes bibliographical references.

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29

Jones, Mara. "N-cadherin mediated cell-cell adhesion in the arterial wall." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58830.pdf.

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30

Steelant, Wim Floris Albert. "Role of antitumor lipids in cell-cell adhesion and invasion." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/56986.

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31

Brown, Marena Dessette. "Sickle cell-endothelial interactions : modulation of cell adhesion molecule expression." Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/11306.

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32

Wongchaowart, Michael B. "Optimization of cell adhesion environments for a liver cell bioreactor." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34156.

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Анотація:

Thesis (M. Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, February 2006.<br>Includes bibliographical references (p. 40-44).<br>The MilliF bioreactor offers great potential for the formation of i vivo-like liver tissue outside the body, making it a valuable tool for applications such as drug toxicity models and biosensors. Cell adhesion is an important factor in the maintenance of differentiated hepatocyte functions. Hepatocyte adhesion environments were examined in two settings: spheroid culture prior to seeding in the bioreactor and 2D surface culture methods t

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33

McCormack, Jessica. "The regulation of cell-cell adhesion by GTPase activating proteins." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/28574.

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Adherens junctions (AJs) are responsible for the adhesion of cells to their neighbours and influence a range of cellular processes. The formation and maintenance of AJs is governed by members of the Rho subfamily of small GTPases. Activation of the GTPases Rac1 and RhoA is necessary for the formation of cell-cell contacts in keratinocytes. However, how the GTPases themselves are regulated is not well understood. Rho GTPase activating proteins (GAPs) inactivate GTPases by promoting the hydrolysis of GTP to GDP. Whilst a large number of proteins containing Rho GAP domains have been identified, k

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34

Lynn, Miriam Elen. "Enterocyte maturity influences adhesion by lactobacillus." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481471.

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35

Piper, James Wilson. "Force dependence of cell bound E-selectin/carbohydrate ligand binding characteristics." Diss., Georgia Institute of Technology, 1997. http://hdl.handle.net/1853/18388.

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36

Yates, Luke Alexander. "Structural studies in cell adhesion and division." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:d66f5602-7e49-4042-8ebf-9457e61d56c3.

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Cell adhesion is a critical process that allows the organisation and functioning of tissues in three-dimensions. However, the replenishing of cells, via cell division, within tissues is equally important for functioning complex life. Both cell adhesion and division are tightly controlled processes and rely on a complex network of signals that, as yet, are not wholly understood. This Thesis presents a structural analysis of several proteins involved in these processes. In the case of cell adhesion, we have made use of high-throughput (HTP) cloning and expression screening technologies in the Ox

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37

Demetriou, Manolis C. "Integrin clipping: A novel adhesion switch." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/290063.

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We previously identified a novel structural variant of the alpha6 integrin called alpha6p. This variant was produced on the cell surface and was missing the β-barrel extracellular domain. Using several different concentrations of amiloride, aminobenzamidine and PAI-1 and the urokinase-type plasminogen Activator (uPA) function blocking antibody (3689) we showed that uPA, acting as a protease, is responsible for production of α6p. We also showed that addition of uPA in the culture media of cells that do not produce α6p, resulted in a dose dependent α6p production. In contrast, the addition of uP

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38

Gallant, Nathan D. "Analysis of Integrin-mediated Cell Adhesion Strengthening Using Surfaces Engineered to Control Cell Shape and Focal Adhesion Assembly." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/7601.

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Cell adhesion to extracellular matrix proteins is critical to physiological and pathological processes as well as biomedical and biotechnological applications. Cell adhesion is a highly regulated process involving initial receptor-ligand binding, and subsequent clustering of these receptors and rapid association with the actin cytoskeleton as focal adhesions are assembled. Focal adhesions enhance adhesion, functioning as structural links between the cytoskeleton and the extracellular matrix and triggering signaling pathways that direct cell function. The objective of this thesis research is

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39

Belusa, Roger. "Role of Na⁺, K⁺-ATPase in cell adhesion and cell volume regulation : mutagenesis of Na⁺, K⁺-ATPase and transfection in embryonic kidney cell line /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4874-7/.

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40

Carrasco, Sabino Dora Isabel. "Adhesion-associated proteins in Drosophila." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612142.

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41

Wurff, A. A. M. van der. "Cell differentiation and adhesion in colorectal cancer." [Maastricht : Maastricht : Universiteit Maastricht] ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=8253.

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42

Telci, Dilek. "Tissue transglutaminase : a novel cell adhesion protein." Thesis, Nottingham Trent University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410526.

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43

Montefort, Stephen. "Cell adhesion in airway mucosal allergic inflammation." Thesis, University of Southampton, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240611.

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44

Chen, Yun-Ju. "The role of dystroglycan in cell adhesion." Thesis, University of Glasgow, 2003. http://theses.gla.ac.uk/30966/.

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Анотація:

Dystroglycan is a heterodimeric transmembrane glycoprotein protein of α and β subunits that links the extracellular matrix to the cytoskeleton. Recent data tend to suggest that the role of dystroglycan in non-muscle cells is for cell adhesion, and cytoskeleton reorganisation signalling. To study the relationship between dystroglycan signalling and ERK signalling in focal adhesions, an YFP-ERK construct was expressed in REF52 cells. YFP-ERK was expressed with ERK activity and formed adhesion-like structures in the REF52 cells, however, no ERK activity was detected in the adhesion-like structure

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45

Nwachukwu, Cynthia Chinwe. "Electrospinning Protein Nanofibers to Control Cell Adhesion." Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1727.

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The structural and mechanical properties of a surface often play an integral part in the determination of the cell adhesion strength and design parameters for creating a biodegradable electrospun scaffold. Nanofibers composed of the globular proteins bovine serum albumin (BSA) and fibronectin were produced by electrospinning with the electrospun protein scaffold serving as an extracellular matrix to which adhesion interaction will exist with cells via cell surface integrin. This interaction is vital in regulation cell differentiation, growth and migration and cell adhesion. We will demonstrate

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46

Palovuori, R. (Riitta). "Regulation of cell-cell adhesion and actin cytoskeleton in non-transformed and transformed epithelial cells." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514269306.

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Abstract Epithelial cell-cell adhesions have a critical role in morphogenesis, establishment and maintenance of tissue architecture, cell-cell communication, normal cell growth and differentiation. These adhesions are disrupted during malignant transformation and tumour cell invasion. Several kinases, phosphatases and small GTPases regulate cell-cell contacts. In the present work we investigated the dynamics of cell-cell adhesion structures after microinjection of fluorophore tagged vinculin, during transformation caused by an active Src tyrosine kinase and during Helicobacter pylori infection

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47

Santos, Tedim Sousa Pedrosa António José. "Chlamydia trachomatis, a cell adhesion architect : the role of TarP and CT228 in Chlamydia trachomatis modulation of host cell focal adhesions." Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=233419.

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Bacterial infection of mucosal epithelial cells triggers cell exfoliation to limit the dissemination of infection within the tissue. Therefore, mucosal pathogens must possess strategies to counteract cell extrusion in response to infection. Chlamydia trachomatis L2 spends most of its intracellular development in the non-infectious form, and premature extrusion of the host cell is detrimental to the pathogen. Here I show that Chlamydia trachomatis L2-infected cells exhibited increase adhesion as demonstrated by increased resistance to detachment by mild trypsinization. In addition, I observed a

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48

Källström, Helena. "Molecular and cellular mechanisms during adherence and cell signaling of pathogenic Neisseria to host cells /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3848-2/.

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49

Redmann, Anna-Lena. "Kinetics of cell attachment and spreading on hard and soft substrates." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/290385.

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A very important aspect for the functioning of an organism is that cells adapt their behaviour to external stimuli. They continuously interact with their environment, and biochemical and physical cues can activate cellular signalling, which leads to changes in cell behaviour such as proliferation and shape. Understanding cells' interactions with their environment is also important for understanding diseases. For example mechanosensing, which is the sensing of the cell's mechanical environment, has been associated with cancer development. In order for a cell to be able to sense its mechanical e

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Franke, Katja. "Adhesion and Single Cell Tracking of Hematopoietic Stem Cells on Extracellular Matrices." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2011. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-77290.

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Анотація:

The local microenvironment of hematopoietic stem cells (HSCs) in the bone marrow -referred to as stem cell niche- is thought to regulate the balance of stem cell maintenance and differentiation by a complex interplay of extrinsic signals including spatial constraints, extracellular matrix (ECM) components and cell-cell interactions. To dissect the role of niche ECM components, a set of well-defined matrix biomolecular coatings including fibronectin, laminin, collagen IV, tropocollagen I, heparin, heparan sulphate, hyaluronic acid and co-fibrils of collagen I with heparin or hyaluronic acid wer

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