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Дисертації з теми "Cellular immunity"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Shimokata, Kaoru. "Cytokines and Local Cellular Immunity." 名古屋大学医学部, 1997. http://hdl.handle.net/2237/6185.

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2

Wuttge, Dirk Marcus. "Cellular immunity and inflammation in atherosclerosis /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-051-2/.

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3

Yassine, Daadaa. "Network Decontamination with Temporal Immunity." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20633.

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Network decontamination is a well known mobile agent problem with many applications. We assume that all nodes of a network are contaminated (e.g., by a virus) and a set of agents is deployed to decontaminate them. An agent passing by a node decontaminates it, however a decontaminated node can be recontaminated if any of its neighbours is contaminated. In the vast literature a variety of models are considered and different assumptions are made on the power of the agents. In this thesis we study variation of the decontamination problem in mesh and tori topologies, under the assumption that when

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4

Makedonas, George. "Cellular immunity among HIV exposed, uninfected individuals." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111828.

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Two models of HIV infection have been studied extensively with the goal of identifying immune correlate(s) of protection against HIV: (1) the simian immunodeficiency virus (SIV) infection of rhesus macaque monkeys and (2) individuals with repeated exposure to HIV who remain uninfected by the virus (EUs). Both paradigms suggest that T cell-mediated immunity plays an important role in controlling HIV replication. Evidence from the SIV/macaque system, however, predicts that HIV vaccines aimed at eliciting T cell responses will fail to induce sterilizing immunity against HIV. The aim of the work p

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5

Tye, Gee Jun. "Combined adjuvant for stimulation of cellular immunity." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/combined-adjuvant-for-stimulation-of-cellular-immunity(b1be07ae-b8d4-40a8-9258-bc3e3413df9d).html.

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Vaccination has important clinical potential in the immunotherapy of both infectious disease and cancer. The central aim of the studies reported in this thesis has been the development of vaccination strategies that will be effective for therapeutic applications in cancer. Using ovalbumin antigen in a mouse model, we have examined a combination of recently developed adjuvants referred to as CASAC (combined adjuvants for synergistic stimulation of cellular immunity) to optimise the efficacy of vaccination induced T cell mediated immunity. These studies have examined the effect of repeated round

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6

Patel, Mihil. "Regulation of cellular immunity by human cytomegalovirus." Thesis, Cardiff University, 2018. http://orca.cf.ac.uk/114496/.

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The success of HCMV as a lifelong pathogen is attributed at least in part to the broad range of encoded immune evasion molecules that inhibit the host cellular immune response. Indeed, HCMV has become a paradigm for immune evasion, the study of which has revealed a number of basic immunological processes. To screen for novel immune evasion genes, HCMV-specific CD8+ T-cell lines were grown from seropositive donors and used against a series of block deletion viruses, each missing a region of genes non-essential for replication in vitro. UL13-UL20 was flagged as important for inhibition of CD8+ T

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7

Abuhammash, E. V. "Transfer actor as mediator of cellular immunity." Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/32144.

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Transfer factor (s) - are small molecules, that transfer the ability to recognize pathogens (bacterial or viral) cells of the immune system, never exposed to this pathogen. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32144

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8

Oldenhove, Guillaume. "Contrôle de la réponse immunitaire induite par les cellules dendritiques: rôle des cellules T régulatrices naturelles ou induites." Doctoral thesis, Universite Libre de Bruxelles, 2006. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210888.

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9

Weber, Wilhelm Evert Jacob. "Cellular auto-immunity in central nervous system disease." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1988. http://arno.unimaas.nl/show.cgi?fid=5594.

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10

Nickless, Jane Christina. "Cellular immunity to acetylcholine receptor in myasthenia gravis." Thesis, University of Bath, 1985. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.767550.

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Nicotinic acetylcholine receptor (AChR) has been purified from Torpedo electric organ, foetal calf muscle, adult human leg muscle, and foetal human skeletal muscle, by extraction in non-ionic detergent followed by affinity purification on immobilised a-toxin. The purified AChR preparations were used to study cellular responses in vitro from patients with myasthenia gravis. In addition, several characterisation studies were carried out on the foetal calf AChR preparation. Purified foetal calf AChR was shown in isoelectric focussing experiments to focus as a single sharp peak at pH 5.2 +/- 0.1,

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11

Watkins, Marcia Linda Vivienne. "Cellular immunity of naïve and BCG vaccinated neonates." Doctoral thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/10984.

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Includes abstract.<br>Includes bibliographical references (leaves 153-187).<br>Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa. The dichotomy that successful pregnancy is usually associated with a type 2 (Th2) cytokine profile in the newborn child, whereas immunity to Mycobacterium tuberculosis (Mtb) is associated with the development of a type 1 helper (Th1) cytokine response, could impact on the subsequent adaptive immune response to BCG vaccination. Previous studies have suggested that immu

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12

Zettervall, Carl-Johan. "Signaling pathways in the activation and proliferation of Drosophila melanogaster blood cells." Doctoral thesis, Umeå : Umeå centrum för molekylär patogenes (UCMP), 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-513.

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13

Haque, Khawaja Mostaq Gausul. "The quantitation of cellular allo-immunity in preparation for monitoring of cellular tolerance." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.389232.

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14

Mäkitalo, Barbro. "HIV and SIV specific cellular immunity in macaque models /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-751-7/.

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15

Struik, Siske Sybrich. "Cellular immune responses and clinical immunity to P. falciparium." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417697.

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16

McLarnon, Andrew. "Cellular mechanisms of alloreactive immunity following stem cell transplantation." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3064/.

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Allogeneic stem cell transplantation is associated with a powerful T cell-mediated ‘graft-versus-leukaemia’ (GvL) effect and also ‘graft-versus-host disease’ (GvHD). Developing therapies to improve survival relies on greater understanding of these responses in order to enhance GvL and suppress GvHD. To gain an increased understanding of the mechanisms of GvHD I measured frequencies of Th1, Th17 and Treg subsets in the blood of 32 GvHD patients (during and outside of disease episodes) and in 21 patients who did not suffer GvHD. No associations between T cell subset frequencies or serum cytokine

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17

Marques, Mariana Campos. "Cellular responses to viral infection : proteostasis and innate immunity." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22054.

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Mestrado em Biomedicina Molecular<br>Viruses are small opportunistic infectious agents. Virus entry, replication and assembly are dynamic and coordinated processes that require precise interactions with host components, often with cellular organelles. Hence, we proposed to study two different viruses affecting two distinct cellular surveillance mechanisms: Human Cytomegalovirus (HCMV) and Influenza A Virus (IAV) influence on the innate immune response and proteostasis, respectively. HCMV might be associated with additional long-term health consequences in human due to its ability to establish

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18

Noble, Roger Lee. "Cellular Immunity in Children with Down Syndrome (Trisomy-21)." DigitalCommons@USU, 1985. https://digitalcommons.usu.edu/etd/4640.

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Individuals with Down syndrome (US) suffer from increased incidence of respiratory infections and lymphoblastic leukemia, and a death rate that is particularly high in the first 5 years of life. Relatively few studies have probed immune parameters in young US children. Primary immune defects in DS may be masked by a degree of immune maturity in adults, and hygienic factors may have an effect on immune capability throughout the years. A study of young children can give clearer evidence of the actual primary immune defects in DS. Blood samples were drawn from 20 DS children under 6 years old and

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19

Temmerman, Stéphane. "Etude de la réponse à médiation cellulaire indute par l'héparin-binding hemagglutinin chez le sujet infecté par Mycobacterium tuberculosis." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211117.

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La tuberculose demeure un problème majeur de santé publique. Mycobacterium tuberculosis infecte un tiers de la population mondiale et environ 3 millions de décès, des suites de l’infection, sont recensés chaque année dans le monde. La mise au point d’une stratégie vaccinale efficace constitue dès lors la solution idéale pour tenter d’éradiquer la bactérie. Le système immunitaire humain répond à l’infection par l’induction d’une réponse cellulaire, caractérisée essentiellement par la sécrétion de médiateurs pro-inflammatoires, comme l’interféron-gamma (IFN-?). A la fois les lymphocytes T CD4+ e

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20

Hawke, Simon. "Cellular immunity to the human acetylcholine receptor in myasthenia gravis." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239315.

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21

Coates, Christopher J. "Hemocyanin-derived phenoloxidase : biochemical and cellular investigations of innate immunity." Thesis, University of Stirling, 2012. http://hdl.handle.net/1893/12228.

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Hemocyanins (Hcs) and phenoloxidases (POs) are both members of the type-3 copper protein family, possessing di-cupric active sites which facilitate the binding of dioxygen. While Hcs and POs share a high degree of sequence homology, Hcs have been associated traditionally with oxygen transport whereas POs are catalytic proteins with a role in innate immunity. Evidence gathered in recent years details numerous immune functions for Hc, including an inducible PO activity. Unlike the pro-phenoloxidase activation cascade in arthropods, the endogenous mechanism(s) involved in the conversion of Hc int

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22

Mackenzie, Danielle K. "Ageing and the cellular immune response in adult Drosophila melanogaster." Thesis, University of Stirling, 2014. http://hdl.handle.net/1893/20882.

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Senescence is the age-related progressive deterioration of physiological processes leading to an increased likelihood of death and is a phenomenon that occurs nearly universally throughout all the world’s organisms. This thesis initially investigated the impact of ageing on the adult Drosophila melanogaster cellular immune response and demonstrated that the cellular immune response in D. melanogaster adults did experience an age-dependent decline in function. There was a striking reduction in haemocyte ability to phagocytose foreign particles with up to 30% less phagocytosis occurring in four

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23

Young, Lauren Jill. "Cellular immune responses of marsupials : family Macropodidae /." View thesis, 2002. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030724.151428/index.html.

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Thesis (Ph.D.) -- University of Western Sydney, 2002.<br>"A thesis submitted to the University of Western Sydney in fulfilment of the requirements for the degree of Doctor of Philosophy" Bibliography : leaves 400-437.

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24

McAuley, Julie Louise. "MUC1 in innate and adaptive immunity /." [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19061.pdf.

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25

Jun, Janice. "THE OFFENSE-DEFENSE BALANCE IN IMMUNITY." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1467997330.

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26

Liew, F. Y. "Cell mediated-immunity against infectious diseases." Thesis, Canberra, ACT : The Australian National University, 1990. http://hdl.handle.net/1885/142999.

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27

Ahanotu, Ejemihu Ndu. "Immune Response of the Rat to Outer Membrane Proteins of Legionella pneumophila." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc935780/.

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Outer membrane proteins (OMPs) were recovered from eleven strains (eight serogroups) of Legionella pneumophila by sequential treatment with Tris buffer (pH 8), citrate buffer(pH 2.75) and Tris buffer (pH 8). Transmission electron microscopy revealed clearly the separation of the outer membrane from the bacteria. The development of delayed hypersensitivity was also noted by measuring the area of arythema and induration produced by intradermal injections of the MPSs from Chicago 8 strain. The adjuvants enhanced greatly both active and cell-meditated immunity (CMI). Transient lymphocytopenia with

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28

Higgins, Melanie Rae. "Identification of novel virulence factors and mechanisms of pathogenesis from the sexually transmitted protozoan Tritrichomonas foetus." Diss., Montana State University, 2006. http://etd.lib.montana.edu/etd/2006/higgins/HigginsM0506.pdf.

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29

Fatime, Ramla Tanko. "Restoration of cellular immunity in HIV-infected individuals on antiretroviral therapy." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25280.

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During the course of HIV pathogenesis, the virus induces multiple defects in immune cells, altering their functional ability to efficiently control HIV itself and other infections. Whilst the widespread implementation of antiretroviral therapy (ART) has led to reduced morbidity and mortality in most HIV-infected individuals having access to treatment, we still do not know whether full restoration of immune function occurs. The aim of this study was to assess the extent to which ART restores both phenotypic and functional T and B cell immunity. HIV-infected women were studied before and 1 year

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30

Xu, Dan. "Cellular Immunity in Recombinant Adeno-Associated Virus Vector Mediated Gene Therapy." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1313504203.

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31

Hollingworth, James. "The manipulation of cellular immunity by monoclonal antibodies in cancer patients." Thesis, University of Leicester, 1994. http://hdl.handle.net/2381/34109.

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The role of an immune response in the development and regulation of tumour growth is outlined. The historical development of immunotherapy in the treatment of human cancer is reviewed and the mechanisms by which immunity may be manipulated in vitro and in vivo with respect to improving cancer immunotherapy are discussed. The experimental studies and laboratory methods finally used are presented and validated in chapter 3. Non-major histocompatibility-restricted cellular cytotoxicity was assessed in a standard 4-hour 51chromium-release assay and peripheral blood cell populations were examined u

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32

Furniss, James John. "Ubiquitin-ligase-mediated transcription initiation in cellular stress defences." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22004.

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Accurate regulation of gene transcription is essential for organismal survival, and is orchestrated by myriad transcription factors and cofactors (TFs). Little is known about how the intrinsic activity of TFs is controlled. Recent work has indicated that the selective proteolysis of TFs provided by the ubiquitin-proteasome system (UPS) plays an important role in stimulating gene expression through a ‘destruction-activation’ mechanism, whereby the degradation of a ‘used’ TF is thought to stimulate further ‘fresh’ TF binding and reinitiate gene transcription. TFs are targeted to the proteasome v

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33

Lorgat, Faizel. "Proliferative and cytotoxic cellular immune responses in human tuberculosis." Thesis, University of Cape Town, 1992. http://hdl.handle.net/11427/26373.

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34

Reed, Jennifer. "Interferon-gamma increases CD4+ T cell survival and proliferation." Click here for download, 2006. http://wwwlib.umi.com/cr/villanova/fullcit?p1432655.

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35

Tran, Tinh Vi. "The hydrolysis rate of fluorescent dipeptides by dipeptidyl peptidase I (DPPI)." Thesis, Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/10132.

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36

Bangham, C. R. M. "The cellular immune response to respiratory syncytial virus in mouse and man." Thesis, University College London (University of London), 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376958.

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37

Beck, Melinda Annetta. "Regulation of cell-mediated immunity during reinfection with influenza virus /." The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487324944212867.

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38

Чорненька, Жанетта Анатоліївна. "CHARACTERISTIC OF INDICATORS OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH DEMODECOSIS." Thesis, Материалы 72-й научно-практической конференции студентов-медиков и молодых ученых с международным участием «Актуальные проблемы современной медицины». Самарканд 11-12 мая 2018 г. С.382, 2018. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/14251.

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39

Lindencrona, Jan Alvar. "Enhancing T cell mediated immunity in DNA vaccination /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-710-x.

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40

Wilder, Sarah A. "The Relationships between Energetic Condition, Immune System Cellular Components, Testosterone Corticosterone, and Hemoparasites in Breeding Birds." Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/WilderSA2007.pdf.

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41

Kischnick, Christian [Verfasser], and Steeve [Akademischer Betreuer] Boulant. "Role of Phosphoinositides in Cellular Polarity and Immunity / Christian Kischnick ; Betreuer: Steeve Boulant." Heidelberg : Universitätsbibliothek Heidelberg, 2018. http://d-nb.info/1177253089/34.

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42

Schanen, Brian. "Novel Immunogens of Cellular Immunity Revealed using in vitro Human Cell-Based Approach." Doctoral diss., University of Central Florida, 2012. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5483.

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Nanotechnology has undergone rapid expansion largely as a result of its enormous potential for applications as biomaterials, drug delivery vehicles, cancer therapeutics, and immunopotentiators. Despite this wave of interest and broad appeal for nanoparticles, evidence of their effect to the human immune system remains scarce. Concerns rise as studies on nanoparticle toxicology continue to emerge indicating that nanomaterials can be acutely toxic and can have long term inflammatory effects as seen in animal models. Based on these findings and the rise in the development of nanoparticle technolo

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43

Muindi, K. M. "Cellular lipids and immunity : characterisation of glycolipids binding the antigen presenting molecule CD1." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670089.

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44

Hou, Lin. "The distribution and characterization of protease-activated receptors in oral mucosa and skin." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286544.

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45

Sermersheim, Matthew Alan. "MG53 is a Novel Regulator of Inflammation and Innate Immunity." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu157121945938419.

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46

Liu, Zhenzhen. "The Roles of Interleukin-27 in Tumor Immunity." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354656185.

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47

Auld, Stuart Kenneth John Robert. "Fitness consequences of cellular immunity : studies with Daphnia magna and its sterilizing bacterial parasite." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5779.

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Immune responses are presumed to contribute to host fitness, either by fighting off infections or via immunopathology. Research in this thesis sought to relate the magnitude of a putative immune response to infection and host and parasite fitness. The experiments and field studies presented here all focus on the interactions between the freshwater crustacean, Daphnia magna and its sterilizing bacterial endoparasite, Pasteuria ramosa, using the number of circulating haemocytes as a measure of host immune activity. I found substantial genetic variation in Daphnia’s cellular response to P. ramosa

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48

English, Kieran. "Deciphering the cellular mechanisms promoting CD4+ T cell-dependent intrahepatic CD8+ T cell immunity." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/27735.

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The liver is the body’s largest internal organ and assumes many important physiological and metabolic functions. It is also well-established that the liver possesses unique immunological properties and a delicate balance between tolerance and immunity exists within this large organ. CD4 T cell help to CD8 T cells has emerged as a critical factor involved in promoting robust CD8 T cell responses against viral and tumour antigens. Studies in humans and chimpanzees indicate that CD4 T cells are critical for strong intrahepatic CD8 T cell responses and the spontaneous control of hepatitis C virus

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49

Vickery, Karen. "The humoral and cellular responses to duck hepatitis B virus." Thesis, The University of Sydney, 1994. https://hdl.handle.net/2123/26913.

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Acute and chronic HBV infection and the resulting liver damage including hepatocellular carcinoma (HCC) are major health problems placing large demands on health resources. In high prevalence areas transmission occurs principally perinatally or in early childhood resulting in a high incidence of chronic life-long carriers. Progress in the study of HBV infection, replication and pathogenesis has depended to a large extent on the development of animal models such as the duck/DHBV model. Although less related to HBV than the mammalian models DHBV was used to demonstrate the unique replication str

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50

De, la Rosa Patricia. "Changes in immune cell populations and the antibody response to Streptococcus pneumoniae after exposure to a mixture of herbicides." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=2929.

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Thesis (Ph. D.)--West Virginia University, 2003.<br>Title from document title page. Document formatted into pages; contains xii, 243 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 213-240).

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