Добірка наукової літератури з теми "Cellule souche neural"
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Статті в журналах з теми "Cellule souche neural":
Cazillis, Michele, Vincent LeLievre, and Pierre Gressens. "Différenciation neurale des cellules souches embryonnaires." médecine/sciences 21, no. 5 (May 2005): 484–90. http://dx.doi.org/10.1051/medsci/2005215484.
Remaud, Sylvie, and Barbara Demeneix. "Les hormones thyroïdiennes régulent le destin des cellules souches neurales." Biologie Aujourd'hui 213, no. 1-2 (2019): 7–16. http://dx.doi.org/10.1051/jbio/2019007.
Nguyen, Lam Son, Julien Fregeac, Christine Bole-Feysot, Patrick Nitschke, Oliver Pelle, and Laurence Colleaux. "Rôle de miR-146a dans la différenciation et l’acquisition de l’identité neurale des cellules souches humaines : pertinence pour les troubles du spectre autistique." Morphologie 101, no. 335 (December 2017): 242. http://dx.doi.org/10.1016/j.morpho.2017.07.010.
Hanna, Peter, Michael J. Dacey, Jaclyn Brennan, Alison Moss, Shaina Robbins, Sirisha Achanta, Natalia P. Biscola, et al. "Innervation and Neuronal Control of the Mammalian Sinoatrial Node a Comprehensive Atlas." Circulation Research 128, no. 9 (April 30, 2021): 1279–96. http://dx.doi.org/10.1161/circresaha.120.318458.
Yaple, Zachary A., and Rongjun Yu. "Functional and Structural Brain Correlates of Socioeconomic Status." Cerebral Cortex 30, no. 1 (May 2, 2019): 181–96. http://dx.doi.org/10.1093/cercor/bhz080.
Heinrichs-Graham, Elizabeth, Brittany K. Taylor, Yu-Ping Wang, Julia M. Stephen, Vince D. Calhoun, and Tony W. Wilson. "Parietal Oscillatory Dynamics Mediate Developmental Improvement in Motor Performance." Cerebral Cortex 30, no. 12 (July 24, 2020): 6405–14. http://dx.doi.org/10.1093/cercor/bhaa199.
CASE, MICHAEL A., and HUGH R. MACMILLAN. "ON SIMULATING THE GENERATION OF MOSAICISM DURING MAMMALIAN CEREBRAL CORTICAL DEVELOPMENT." Journal of Biological Systems 17, no. 01 (March 2009): 27–62. http://dx.doi.org/10.1142/s0218339009002740.
Herrera, Alejandro, Sara Morcuende, Rocío Talaverón, Beatriz Benítez-Temiño, Angel M. Pastor, and Esperanza R. Matarredona. "Purinergic Receptor Blockade with Suramin Increases Survival of Postnatal Neural Progenitor Cells In Vitro." International Journal of Molecular Sciences 22, no. 2 (January 12, 2021): 713. http://dx.doi.org/10.3390/ijms22020713.
Zhang, Furu, Kazuhiro Kurokawa, Ayoub Lassoued, James A. Crowell, and Donald T. Miller. "Cone photoreceptor classification in the living human eye from photostimulation-induced phase dynamics." Proceedings of the National Academy of Sciences 116, no. 16 (April 3, 2019): 7951–56. http://dx.doi.org/10.1073/pnas.1816360116.
Zhang, J. S., and F. M. Longo. "LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats." Journal of Cell Biology 128, no. 3 (February 1, 1995): 415–31. http://dx.doi.org/10.1083/jcb.128.3.415.
Дисертації з теми "Cellule souche neural":
Loison-Robert, Ludwig. "Cellule souche gingivale : origine et multipotence." Thesis, Paris Est, 2016. http://www.theses.fr/2016PESC0083/document.
Gingiva is a natural regeneration model thanks to its "ad integrum" healing capability. Gingival fibroblasts are the main actors of this property. These cells, the main cellular component of the gingival connective tissue, regulate the inflammatory responses and healing process. This tissue contains, like many others, mesenchymal stem cells; which also partly explain these regenerative abilities. Moreover, as the gingiva is abundant and easily accessible, the use of these stem cells may interest cell therapy or in vitro model tissues responses. In this work, we demonstrated that Stem Cells Derived from Human Gingiva (SCHG) have common properties with neural crest adult stem cells. These cells can be called "stem cells" for their ability to self-renew, adhere to plastic and to differentiate. First, we have shown that the method and the culture products used for isolation of gingival fibroblasts from gingival biopsy had an influence on the obtained cells. Secondly, an analysis of in vitro clonal populations of gingival fibroblasts has shown that gingival fibroblasts are composed of subpopulations that express specific markers of stem cells and neural crests. In addition to their embryological origin, the study of their multipotency was also characterized after expansion and depending on the used additives. Finally, two examples of using these cells and dental pulp stem cells as a model to study the in vitro biocompatibility of biomaterials have been developed, mimicking oral mucosa or dentin reactions (reparative or reactional)
Katz, Shauna. "Rôle de microARN-9 dans la régulation de l'état cellule souche neural chez l'adulte." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS086.
Since the seminal discovery of multipotent neural stem cells (NSCs) in the adult mammalian brain, multiple studies have unravelled the importance of these cells for maintaining brain homeostasis. Notably, disturbances in NSC equilibrium have been linked to physiological aging and various neurological pathologies thus sparkling interest in harnessing them for use in regenerative medicine. NSCs reside in distinct germinal zones; in the adult rodent brain NSCs are found mainly in two well-established neurogenic niches in the telencephalon which contrasts with the situation in the adult zebrafish where NSC niches are widespread throughout the brain, including in the dorsal telencephalon or pallium. In both the rodent and zebrafish brains, adult NSCs display fundamental stem cell properties: they are multipotent, e.g. capable of generating new neurons and glia throughout adult life, and have the capacity for long-term self-renewal. Similar to stem cells in other adult tissues, and in contrast to embryonic neural progenitors, a hallmark of these adult NSCs is their relative proliferative quiescence. Quiescence is an actively maintained, reversible state of cell-cycle arrest and generally thought to protect against exhaustion of the stem cell pool. In line with this, disrupting the balance between quiescent and activated NSCs leads to a premature depletion or permanent cell-cycle exit of these cells highlighting the importance of fully deciphering the mechanisms regulating this equilibrium. microRNAs, a major class of small pleiotropic regulatory RNAs, play crucial roles in reinforcing developmental and transitional states. They are capable of reacting to environmental cues, both cell-intrinsic and -extrinsic, with varying outputs such as changing their regulatory functions and expression levels, thus enabling them to coordinating diverse cues to induce cell-state transitions. One microRNA in particular, miR-9, is a highly conserved master regulator of embryonic neurogenesis and in the embryonic zebrafish brain, it establishes a primed neural progenitor state enabling them to quickly respond to cues to differentiate or proliferate. The primary goal of this study was to investigate, for the first time, a potential role for miR-9 in influencing NSC state in a physiological context in which the majority of NSCs are quiescent – the adult zebrafish pallium. We found that miR-9 is exclusively expressed in quiescent NSCs and highlights a “sub-state” within quiescence. In part by maintaining high levels of Notch signalling, a known quiescence promoting pathway, miR-9 anchors NSCs in the quiescent state. Strikingly, we identified a conserved age-associated change in the subcellular localization of the mature miR-9 from the cytoplasm of all embryonic/juvenile neural progenitors to the nucleus of a subset of quiescent NSCs in the adult brain. Moreover, the nuclear expression of miR-9 in these quiescent NSCs is highly correlated with nuclear localization of the microRNAs effector proteins Argonaute (Agos), suggestive of a functional role for nuclear miR-9. Indeed, the elucidation of the nuclear-cytoplasmic transport mechanism of miR-9/Agos enabled us to manipulate their nuclear to cytoplasmic ratios which directly impacted NSC state. Altogether, these results identify miR-9 as a crucial regulator of NSC quiescence, provide for the first time a molecular marker for an age-associated sub-state of quiescence and suggest the involvement of a novel and unconventional microRNA-mediated mechanism to maintain homeostasis of NSC pools
Clavairoly, Adrien. "Ascl1 and Olig2 transcriptional regulations of oligodendrogenesis." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066316/document.
Our project aims to provide a new molecular understanding of the transcription program involved in neural stem cells differentiation into oligodendrocytes. The rational of this work relies on previous studies demonstrating that the bHLH transcription factors Olig2 and Ascl1 work in synergy to specify OPCs, the oligodendrocyte progenitor cells. One central goal of this work was to understand at a genomic and transcriptomic level, how Ascl1 and Olig2 work together to specify OPCs. We followed a strategy using genome-wide transcriptome analysis and chromatin immuno-precipitation to characterize Ascl1 and Olig2 directly regulated genes in OPCs and during oligodendrocyte differentiation.We identified new specific markers of different stage of the neural lineages and new important genes correlated to OPCs differentiation. We focused on Chd7 and Tns3, two genes which expressions are driven by Ascl1 and Olig2 and enriched in the oligodendroglial lineage at two interesting stage, the early specification stage and the transition between migrating and differentiating oligodendrocytes, respectively. Moreover, we identified the myelinating oligodendrocyte as the cell in charge of the creatine synthesis in the brain and potentially driving axonal metabolic support. We also used an approach a toxicogenomic and drug repositioning approach to identify new molecules known to modify OPCs and myelin genes but untested in the context of demyelinating diseases. As currently, most of the available treatments for demyelinating diseases are based on immuno-modulatory and anti-inflammatory drugs but none are able to directly promote myelin repair, we expect that these identified genes involved in oligodendrogenesis and whose expression are regulated in demyelinated lesions will allow the development of new therapeutic strategies promoting an efficient remyelination in demyelinating diseases such as Multiple sclerosis or leukodystrophies
Flici, Hakima. "Différenciation et plasticité des cellules souches neurales." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-01070644.
Terrie, Élodie. "Rôle de la signalisation calcique dépendante des Store-Operated Channels (SOC) dans les cellules souches neurales adultes et les cellules souches cancéreuses de glioblastomes." Thesis, Poitiers, 2019. http://www.theses.fr/2019POIT2322.
Neural stem cells (NSC) persist in the brain of adult mammals and fuel the brain with new neurons and glial cells all lifelong. Recruited by brain injuries, NSC are considered with great interest by regenerative medicine. However, the development of new therapeutic approaches based on the use of NSC requires an in-depth knowledge of the mechanism regulating these cells. Glioblastomas are the most frequent and deadliest form of adult brain tumors. Within the tumor, glioblastoma stem cells (GSC) form a subpopulation of cells that is considered as responsible of tumor initiation, propagation and relapse, as these cells are particularly resistant to anti-tumoral treatments. GSC and NSC share key characteristics and numerous studies suggest that GSC arise from transformed NSC. Transcriptomic analysis of NSC and of GSC revealed an enrichment of calcium signaling transcripts in these two cell populations. Representing a major way of calcium influx into cells, Store-Operated Channels (SOC) are mobilized in response to a wide range of extracellular factors. SOC regulate many cellular processes and are often hijacked in cancer to promote tumor progression.The aim of this thesis is to evaluate potential SOC involvement in NSC and GSC regulation.The first part of this work, relying on in vitro and in vivo studies, demonstrates that NSC from adult mice express functional SOC whose inhibition by pharmacological agents reduces NSC proliferation and self-renewal. In the second part of this thesis, we demonstrate that GSC from primary cultures derived from patients express SOC, as do NSC, and that SOC inhibition reduces GSC ability to proliferate and self-renew.Accordingly, the results of this thesis demonstrate that SOC regulate NSC and GSC self-renewal, a property that is essential to maintain stem cells pool. As GSC are responsible for glioblastomas treatment resistance, our studies point to a potential new therapeutic way, via calcium channels, against this deadly pathology
Mancini, Laure. "Spatiotemporal control of Neural Stem Cell decisions in the adult zebrafish telencephalon." Thesis, Sorbonne université, 2020. http://www.theses.fr/2020SORUS154.
In some regions of the adult vertebrate brain, Neural Stem Cells (NSCs) generate fully functional neurons. NSCs are found mostly in quiescence, but can shuttle from quiescence to activation (division). At the population level, the proportion of NSCs dividing at a given time remains constant throughout adulthood and perturbations of NSC activation rate correlate with pathological situations. Also, the spatiotemporal distribution of NSC activation events is expected to impact the homogeneous maintenance of the NSC pools and the locations of neuronal production. What controls the rate and spatiotemporal distribution of NSC activation events remain poorly understood. The adult zebrafish telencephalon is a good model to address these questions. The telencephalon hosts many NSCs and it allow the recording of their behaviors over weeks thanks to an intravital imaging procedure. In this thesis, we have used this model to study the regulation of adult NSCs behaviors from two perspectives. First, we assessed the existence of non-cell-autonomous mechanisms controlling the quiescence-activation balance of the NSC population in space and time. Second, we investigated the relevance of intrinsic heterogeneities on individual NSC behaviors. This work highlighted (i) the importance of NSC geometry for their fate decisions during activation and (ii) the role of their differentiated progeny to locally exert a delayed inhibition, via Notch signaling, to prevent neighboring NSC activation. Using modeling we also show how the lineage-related inhibition maintains NSCs with specific spatiotemporal correlations and can spatially homogenize the distribution of adult-born neurons
Jourdon, Alexandre. "Prss56Cre, un nouvel outil pour l'étude de la neurogenèse adulte chez la souris." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066082/document.
The Prss56 gene encodes a serine protease involved in eye pathologies and development in humans. Prss56 expression pattern and function in the rest of the central nervous system were however unknown. Here, I used a knock-in allele in the mouse, Prss56Cre, carrying a Cre recombinase insertion in the locus, to establish the pattern of expression of the gene and to trace the derivatives of Prss56-expressing cells. I found that, in the adult mouse, Prss56 is specifically expressed in three neurogenic niches: the dentate gyrus (DG), the subventricular zone (SVZ) and the hypothalamus ventricular zone (HVZ). In the prospective DG, Prss56 is expressed during embryogenesis in a subpopulation of radial glia. Consistently, the pattern of migration and differentiation of traced cells during development recapitulates the successive steps of DG neurogenesis, including the formation of a subpopulation of adult neural stem cells (aNSC). In the SVZ, Prss56 is expressed after birth in a subpopulation of aNSC mainly localized in the medial-ventral region of the lateral wall. This subpopulation preferentially gives rise to deep granule and calbindin-positive periglomerular cells in the olfactory bulb. Finally, Prss56 is also expressed in a subpopulation of alpha2-tanycytes, potential aNSC of the adult HVZ. My observations reveal that some traced tanycytes translocate their soma into the parenchyma and might give rise to a novel cell type in this territory. In conclusion, this study establishes the Prss56Cre line as a novel and efficient tool to study various aspects of adult neurogenesis in the mouse
Daynac, Mathieu. "Caractérisation des facteurs de régulation de la prolifération des cellules souches neurales dans le cerveau adulte." Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00968161.
Angonin, Diane. "Lineage-specific manipulation of subventricular zone germinal activity for neonatal cortical repair." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1175/document.
Perinatal hypoxia leads to degeneration and delayed maturation of oligodendrocytes and cortical glutamatergic neurons. My PhD project consists in assessing the contribution of neural stem cells (NSCs) of the dorsal subventricular zone (dSVZ, i.e. the largest germinal zone of the postnatal brain) to the spontaneous regenerative attempt observed following such injury as well as its amenability to pharmacological manipulation.The results I have obtained highlight a dynamic and lineage-specific response of NSCs of the dSVZ to hypoxia that results in de novo oligodendrogenesis and cortical neurogenesis. Newborn cortical neurons express appropriate cortical layer markers, supporting their appropriate specification. A pharmacogenomics analysis allowed us to identify small molecules boosting specificly dSVZ NSCs. Pharmacological activation of Wnt/ß-catenin signalling by intranasal GSK3ß inhibitor administration during the recovery period following hypoxia indeed potentiates dorsal SVZ participation to post-hypoxia repair. Gsk3b inhibitor CHIR99021 seems to promote survival of cortical neurons from the dSVZ produced in response to hypoxia. More interestingly, CHIR99021 promotes oligodendrocyte maturation and long term integration in the cortex as well as a long term increased activity of dSVZ NSCs.Altogether, my results highlighted a dynamic and lineage-specific response of dorsal NSCs cells to hypoxia and identify the early postnatal dorsal SVZ as a malleable source of stem cells for cortical repair following trauma that occur early in life. CHIR99021 (a Gsk3b inhibitor) intranasal administration promotes this cortical cellular repair with a long term activation of dSVZ NSCs which increased their production of oligodendrocytes migrating to the cortex and a short term improvement of their maturation, and might allow the integration of cortical neurons they produce
Chaves, Vieira Lins Luanda. "Study and development of electrospun fibers for biotechnology application." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSEI073.
Currently, the electrospinning process is also one of the most promising routes for the design and development of polymer fibers. This technique is easy to use, unique, versatile, and low cost, which can be used to create fibers from a variety of starting materials. The structure, chemical and mechanical stability, functionality, and other properties of the fibers can be modified to match end applications. The first goal of this thesis was to develop scaffolds for the field of neural tissue engineering in order to mimic the biological, physical and mechanical properties of the native extracellular matrix. In the first time, the effect of fiber alignment of a biocompatible and fluorinated matrix denoted polyvinylidene fluoride (PVDF) was studied on the behavior of monkey neural stem cells particularly the morphology, cell adhesion and their differentiation in glial or neuronal cells. Secondly, bioabsorbable scaffolds composed of polylactide (PLA) and polyethylene glycol (PEG) polymers were synthesized to investigate the influence of the hydrophilic-hydrophobic balance on the culture of neural stem cells. Finally, an exploratory work was conducted to develop smart textiles based on poly(butylene adipate-co-terephthalate) (PBAT) containing curli as protein, well-known for its ability to chelate metals
Частини книг з теми "Cellule souche neural":
Zhong, Yongmin, Bijan Shirinzadeh, and Xiaobu Yuan. "Optimal Robot Path Planning With Cellular Neural Network." In Rapid Automation, 491–511. IGI Global, 2019. http://dx.doi.org/10.4018/978-1-5225-8060-7.ch023.
Bianchi, Thomas S., and Elizabeth A. Canuel. "Carbohydrates: Neutral and Minor Sugars." In Chemical Biomarkers in Aquatic Ecosystems. Princeton University Press, 2011. http://dx.doi.org/10.23943/princeton/9780691134147.003.0005.
Moore, Jennifer C., Michael Sheldon, and Jay A. Tischfield. "Biobanking of Human Induced Pluripotent Stem Cells for Psychiatric Research." In Psychiatric Genetics, 203–14. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190221973.003.0013.
Nicolás-García, Mayra, Cristian Jiménez-Martínez, Madeleine Perucini-Avendaño, Brenda Hildeliza Camacho-Díaz, Antonio Ruperto Jiménez-Aparicio, and Gloria Dávila-Ortiz. "Phenolic Compounds in Legumes: Composition, Processing and Gut Health." In Legumes [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98202.
Тези доповідей конференцій з теми "Cellule souche neural":
Li, Lulu, Rene Schloss, Noshir Langrana, and Martin Yarmush. "Effects of Encapsulation Microenvironment on Embryonic Stem Cell Differentiation." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192587.
Monfared, Omid, Dragan Nesic, Dean R. Freestone, David B. Grayden, Bahman Tahayori, and Hamish Meffin. "Electrical stimulation of neural tissue modeled as a cellular composite: Point Source electrode in an isotropic tissue." In 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2014. http://dx.doi.org/10.1109/embc.2014.6944711.
Kim, Gyu-Sik, та Kyung-Chul Choi. "Abstract B13: A growth of human choriocarcinoma cells was selectively inhibited by therapeutic neural stem cells expressing cytosine deaminase and interferon-β in cellular and xenograft models". У Abstracts: AACR International Conference: New Frontiers in Cancer Research; January 18-22, 2017; Cape Town, South Africa. American Association for Cancer Research, 2017. http://dx.doi.org/10.1158/1538-7445.newfront17-b13.
Tokumaru, Kumon. "The Three Stage Digital Evolution of Linguistic Humans." In GLOCAL Conference on Asian Linguistic Anthropology 2019. The GLOCAL Unit, SOAS University of London, 2019. http://dx.doi.org/10.47298/cala2019.12-2.