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Дисертації з теми "Chronic hepatitis B virus infection"

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1

Williams, Stephen John. "Chronic hepatitis B virus infection : prevention and treatment." Thesis, The University of Sydney, 1989. https://hdl.handle.net/2123/26390.

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Анотація:
Hepatitis B virus (HBV) infection is an increasing public health problem in Australia particularly in certain 'high-risk' subgroups of the population. In order to establish cost-effective screening and vaccination programs directed towards the control and possible eradication of HBV infection, accurate information is needed about the modes of spread and the numbers of "at risk" individuals in particular community subgroups. In addition, treatment strategies must be developed for established HBV carriers since at least 35% of such individuals will die directly related to complications of the di
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2

駱淑芳 and Suk-fong Anna Lok. "Replication of hepatitis B virus in Chinese patients with chronic hepatitis B virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31981392.

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3

Stoop, Jeroen nicolaas. "Regulatory T cells in chronic hepatitis B virus infection." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/11766.

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4

Lopes, Agnel Ross. "CD8+ T cell attrition in chronic hepatitis B virus infection." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444224/.

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Hepatitis B virus (HBV)-specific CD8+ T cells are critical for a successful immune response to HBV infection. These cells are markedly diminished in patients that are unable to contain the virus and the mechanisms contributing to their depletion are not well-understood. The aim of this work was to further dissect this response in individuals with chronic infection. Studies of the HBV-specific CD8+ T cell immunodominance hierarchy demonstrated that persistent infection was associated with a hyporesponsiveness that was exacerbated with increasing antigenic load. The immunodominant core 18-27-spe
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5

Yuen, Man-fung, and 袁孟峰. "Chronic hepatitis B virus infection in the Chinese: natural history, sequelae, treatment and prevention." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B2333177X.

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6

劉耀南 and Yiu-nam Lau. "Interferons and tumour necrosis factor in chronic hepatitis B virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1990. http://hub.hku.hk/bib/B31981446.

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7

Lau, Yiu-nam. "Interferons and tumour necrosis factor in chronic hepatitis B virus infection." Hong Kong : University of Hong Kong, 1990. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2158879X.

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8

Taal, Maarten Willem. "Control of Hepatitis B and C virus infection in chronic haemodialysis patients." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/25675.

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Chronic haemodialysis patients have a high prevalence of Hepatitis B and C virus infections both of which are associated with chronic liver disease and hepatocellular carcinoma Hepatitis B virus (HBV) was identified as a frequent cause of hepatitis during the early years of chronic haemodialysis therapy and strict adherence to infection control measures alone proved inadequate to control the transmission of infection between patients. A policy of regular screening of all patients and blood donations for hepatitis B surface antigen together with isolation of positive patients to separate dialys
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9

Wang, Yudong. "The role of regulatory T cells in chronic hepatitis B virus infection." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43223990.

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10

Wang, Yudong, and 汪玉東. "The role of regulatory T cells in chronic hepatitis B virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43223990.

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11

ISHIKAWA, TETSUYA. "IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION : RATIONALE AND CLINICAL APPLICATION." Nagoya University School of Medicine, 2012. http://hdl.handle.net/2237/16732.

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12

Tachtatzis, Phaedra Maria. "Accelerated ageing, senescence and the natural history of chronic hepatitis B virus infection." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=228557.

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Анотація:
Hepatitis B virus infection (HBV) is an important health problem worldwide, with a significant rate of chronic infection, which can lead to cirrhosis and hepatocellular carcinoma (HCC). Increased age is an important determinant of progression to cirrhosis and HCC, possibly because age is a crude measure of the duration of HBV infection. Increasing age is associated with changes in liver structure, blood flow and function and with reduced response to injury, impaired regeneration and increased mortality in acute liver disease. Age has been identified as a co‐factor in several chronic liver dise
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13

Peppa, D. "Antiviral and immunoregulatory roles of natural killer cells in chronic hepatitis B virus infection." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1394604/.

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Persistent infection with hepatitis B virus (HBV) is a global health burden accounting for more than a 1 million deaths worldwide. Much work has focused on the failure of the adaptive immune response in persistent HBV infection. In contrast innate responses remain poorly characterised. Accumulating evidence indicates the involvement of NK cells in the control of viral infections and shaping of adaptive immunity. Here we investigated the antiviral and immunoregulatory potential of NK cells in chronic Hepatitis B virus infection (CHB). The combination of immunosuppressive cytokines seen in CHB s
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14

Lee, Wing-yan. "Association of cytokine gene polymorphisms with susceptibility and disease progression in chronic hepatitis B virus (HBV) infection." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39556955.

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15

Lee, Wing-yan, and 李穎欣. "Association of cytokine gene polymorphisms with susceptibility and disease progression in chronic hepatitis B virus (HBV) infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39556955.

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16

Zhou, Jie. "Genetic polymorphisms of type I interferon receptor 1 affect the susceptibility to chronic HBV infection association analysis and mechanistic investigation /." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38722951.

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17

周婕 and Jie Zhou. "Genetic polymorphisms of type I interferon receptor 1 affect the susceptibility to chronic HBV infection: association analysis and mechanistic investigation." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38722951.

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18

Webster, George John Mitchell. "The role of virus-specific T cell immunity in the pathogenesis of acute and chronic hepatitis B virus infection." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397760.

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19

Du, Yanqin [Verfasser], and Heiner [Akademischer Betreuer] Wedemeyer. "The impact of hepatitis B surface antigen on natural killer cells in patients with chronic hepatitis B virus infection / Yanqin Du ; Betreuer: Hans-Heinrich Wedemeyer." Duisburg, 2021. http://d-nb.info/123654014X/34.

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20

Torre, Francesco Biagio. "Mutations in the hepatitis B virus pre-core/core gene and their impact on the evolution of chronic HBV infection." Thesis, King's College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248179.

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21

Opio, Alex Achol. "HIV-1 and coinfection with hepatitis B and delta viruses: What is the impact of HIV-1 infection on hepatitis B chronic carriage and the sero-prevalence of delta virus in Uganda?" Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1057847652.

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22

Kgatle, Mankgopo Magdeline. "An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/8800.

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Includes bibliographical references.<br>Hepatitis B virus (HBV) is oncogenic and a major cause of hepatocellular carcinoma (HCC) in the developing world. It integrates parts of its genome such as the HBx gene, core and surface antigens into the human genome. The integrated viral DNA disrupts gene function resulting in physiological changes that cause liver disease. The viral inserts are inactivated through methylation. This is a protective innate response driven by human DNA methyltransferases triggered by the presence of viral DNA inserts. This thesis investigates the hypothesis that during t
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23

Moeed, Abdul [Verfasser], Percy A. [Akademischer Betreuer] Knolle, Percy A. [Gutachter] Knolle, and Jörg [Gutachter] Durner. "Development of a therapeutic vaccine against chronic Hepatitis B virus infection in a preclinical model system : Therapeutic vaccine against chronic HBV infection / Abdul Moeed ; Gutachter: Percy A. Knolle, Jörg Durner ; Betreuer: Percy A. Knolle." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1221719440/34.

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24

Christie, John Michael Landale. "Viral persistence in hepatitis C virus infection." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268465.

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25

Umeda, Makoto. "Hepatitis B virus infection in lymphatic tissues in inactive hepatitis B carriers." Kyoto University, 2007. http://hdl.handle.net/2433/135682.

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26

Luo, Ying. "Hepatitis B virus specific immune response after liver transplantation for chronic hepatitis B /." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3697724X.

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27

Luo, Ying, and 羅英. "Hepatitis B virus: specific immune response after liver transplantation for chronic hepatitis B." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B3697724X.

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28

Sangfelt, Per. "Prevention and treatment of hepatitis B virus infection /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-301-9/.

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29

杜鈺輝 and Yuk-fai To. "Mannose binding lectin in hepatitis B virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31225214.

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30

To, Yuk-fai. "Mannose binding lectin in hepatitis B virus infection /." Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23435987.

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31

Frodsham, Angela J. "The genetics of susceptibility to chronic hepatitis B infection." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393514.

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32

Khakoo, Salim Iqbal. "Immunological and virological factors in chronic hepatitis B infection." Thesis, University College London (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.264209.

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33

Wong, Ka-ho Danny, and 王嘉豪. "Quantitation of hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29938855.

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34

Lu, Lei, and 呂雷. "Effects of antiviral therapies on hepatitis B virus relicaptive intermediates in chronic hepatitis B." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42182359.

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35

Lu, Lei. "Effects of antiviral therapies on hepatitis B virus relicaptive intermediates in chronic hepatitis B." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42182359.

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36

Abbas, Amro M. "Pathogenesis of disease associated with chronic hepatitis C virus infection." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368251.

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37

Ramanan, Vyas. "Genomic profiling and perturbation of Hepatitis B virus infection." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107341.

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Thesis: Ph. D. in Biomedical Engineering, Harvard-MIT Program in Health Sciences and Technology, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 136-153).<br>The Hepatitis B virus (HBV) has, at one time or another, infected one third of the world's population, and over 300 million people worldwide are chronically infected, leading often to progressive liver damage, cirrhosis, and the development of hepatocellular carcinoma over decades. While an effective vaccine exists, imperfect vaccine penetrance and perinatal transmission result in the continuou
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38

Qirbi, Naseeb. "Hepatitis B virus infection in the Republic of Yemen." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2004. http://researchonline.lshtm.ac.uk/1343270/.

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A community-based cross-sectional household seroepdemiological survey was conducted in the Republic of Yemen to estimate the prevalence of HBV infection as well as hepatitis B vaccine coverage and effectiveness amongst children vaccinated in the country's Expanded Programme on Immunisation (EPI). Study subjects were randomly selected from five provinces in the country based on probability proportional to size. The prevalence of HBV chronic infection amongst women of childbearing age participating in the survey was 5.08% and places Yemen amongst the group of countries with a high endemicity of
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39

Hultgren, Catharina. "Immune modulation in chronic HBV and HCV infection /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4255-2/.

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40

Marusawa, Hiroyuki. "Latent hepatitis B virus infection in healthy individuals with antibodies to hepatitis B core antigen." Kyoto University, 2000. http://hdl.handle.net/2433/180879.

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41

Lai, Ching-lung. "Chronic hepatitis B-related liver diseases in the Chinese." Hong Kong : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13814060.

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42

Seto, Wai-kay Walter, and 司徒偉基. "Virologic and serologic kinetics in the natural history and treatment of chronic hepatitis B." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B48671071.

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This thesis investigated how virologic and serologic kinetics of the hepatitis B virus (HBV) could influence the natural history and treatment of chronic hepatitis B (CHB). Virologic kinetics were described in the first five studies, with serologic kinetics being described in the next five. The first study delineated the HBV DNA profiles of 1,400 treatment-naive Asian CHB patients. Increasing viremia was noted with increasing age, highlighting the large therapeutic demand in Asian patients with hepatitis B e antigen (HBeAg)-negative CHB. The second study analyzed the association between vira
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43

Hoang, Xuan Su. "The control of immune responses in chronic hepatitis C virus infection." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV011/document.

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L'infection par le virus de l'hépatite C implique des processus d'interaction complexe entre l'hôte et le virus. Plusieurs facteurs de l'hôte incluant des polymorphismes génétiques et les réponses immunitaires influent sur l'infection et les réponses au traitement. Aussi, il est important d'identifier en amont les facteurs pour prédire la réponse au traitement. L'objectif de la thèse est d'étudier l'influence de certains polymorphismes génétiques de l'hôte sur la réponse à la bithérapie et sur le statut immunitaire du foie dans l'infection chronique par le VHC. L'étude a porté sur les polymorp
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44

Lai, Ching-lung, and 黎靑龍. "Chronic hepatitis B-related liver diseases in the Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B31981501.

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45

Dias, Aruna. "Chronic hepatitis B infection in the immigrant communities of East London." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8963.

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Worldwide there are 350 million people with chronic hepatitis B infection and globally it causes up to half of the liver cancer deaths and one third of deaths from cirrhosis. Only a fraction of sufferers will develop these complications. Various studies have implicated socio-demographic, biochemical and viral factors in disease progression but research has been limited to local populations in endemic countries. Our aim was to study the prevalence and factors associated with advanced disease of hepatitis B infection in immigrants living in East London. I completed a retrospective analysis of no
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46

Yuen, Man-fung. "Role of hepatitis B virus genotypes B and C on chronic liver disease in the Chinese." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B33710089.

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47

Saul, April Leigh. "The Role of e-Antigen in Hepatitis B Infection." Thesis, Virginia Tech, 2015. http://hdl.handle.net/10919/53957.

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Mathematical modeling of biological systems has improved the knowledge of scientists for many years. In virology, particularly in the study of hepatitis B virus, mathematical models were used to explain interactions between hepatitis B virus and the human host in the absence and presence of interventions such as drug therapy and vaccines. This thesis seeks to explain the role of e-Antigen, a particle produced by hepatitis B virus, in the pathogenesis of hepatitis B infection. To accomplish this goal, I will provide biological background as well as previous modeling work on the role of e-Antige
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48

Verbaan, Hans. "Chronic hepatitis C infection with special reference to prevalence, aggravating factors and longterm outcome /." Lund : Gastroenterology and Hepatology Division, Dept. of Medicine, University Hospital, Lund University, 1997. http://books.google.com/books?id=SBdrAAAAMAAJ.

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49

Pembroke, Thomas. "Natural killer cell activation and evasion during chronic hepatitis C virus infection." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/58428/.

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Hepatitis C virus (HCV) infects 3% of the global population and HCV-related liver inflammation is a major cause of liver failure and hepatocellular carcinoma. Current treatments are based upon long courses of interferon-α (IFNα) injections, which have significant side effects and are only effective in 40-80% of individuals depending on viral genotype. Natural killer (NK) cells are innate lymphocytes, which can kill virally infected cells and are stimulated by IFNα. To establish a chronic infection HCV must evade immune responses. I hypothesised that NK cells are important for the successful er
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50

Bulteel, Naomi Sarah. "Predictors of disease progression and outcome in chronic hepatitis C virus infection." Thesis, University of Glasgow, 2018. http://theses.gla.ac.uk/9079/.

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Chronic HCV infection (CHC) is a significant cause of both liver related and non-liver related morbidity and mortality worldwide. Disease progression through to cirrhosis and hepatocellular carcinoma is highly variable, and once chronicity of infection has been established, the likelihood of spontaneous clearance without antiviral treatment is extremely low. Safe and highly effective oral antiviral therapy is now available for the treatment of CHC, however price and accessibility may limit the global use of these agents. Furthermore, concerns have been raised regarding the incidence of hepatoc
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