Добірка наукової літератури з теми "Clonal heterogeneity"
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Статті в журналах з теми "Clonal heterogeneity":
Schuringa, Jan Jacob, and Constanze Bonifer. "Dissecting Clonal Heterogeneity in AML." Cancer Cell 38, no. 6 (December 2020): 782–84. http://dx.doi.org/10.1016/j.ccell.2020.11.011.
Campos, Paulo R. A., Pedro S. C. A. Neto, Viviane M. de Oliveira, and Isabel Gordo. "ENVIRONMENTAL HETEROGENEITY ENHANCES CLONAL INTERFERENCE." Evolution 62, no. 6 (June 2008): 1390–99. http://dx.doi.org/10.1111/j.1558-5646.2008.00380.x.
Rousselot, Philippe. "Clonal heterogeneity in acute lymphoblastic leukemias." Hématologie 17, no. 2 (March 2011): 120–22. http://dx.doi.org/10.1684/hma.2011.0601.
Shlush, Liran I., and Dov Hershkovitz. "Clonal Evolution Models of Tumor Heterogeneity." American Society of Clinical Oncology Educational Book, no. 35 (May 2015): e662-e665. http://dx.doi.org/10.14694/edbook_am.2015.35.e662.
Quinn, Jason George, and Irene Sadek. "Clonal heterogeneity in plasma cell myeloma." Lancet 387, no. 10022 (March 2016): e22. http://dx.doi.org/10.1016/s0140-6736(15)00384-0.
Takhaveev, Vakil, and Matthias Heinemann. "Metabolic heterogeneity in clonal microbial populations." Current Opinion in Microbiology 45 (October 2018): 30–38. http://dx.doi.org/10.1016/j.mib.2018.02.004.
García-Marqués, Jorge, and Laura López-Mascaraque. "Clonal Identity Determines Astrocyte Cortical Heterogeneity." Cerebral Cortex 23, no. 6 (May 22, 2012): 1463–72. http://dx.doi.org/10.1093/cercor/bhs134.
Alonso-Alvarez, Sara, Alba Redondo-Guijo, Óscar Blanco, Miguel Alcoceba, Ana Balanzategui, Juan C. Caballero, Julio Dávila, et al. "Lymphoma Heterogeneity: Three Different Histological Pictures and One Unique Clone." Case Reports in Hematology 2016 (2016): 1–4. http://dx.doi.org/10.1155/2016/3947510.
Nepstad, Ina, Kimberley Joanne Hatfield, Tor Henrik Anderson Tvedt, Håkon Reikvam, and Øystein Bruserud. "Clonal Heterogeneity Reflected by PI3K-AKT-mTOR Signaling in Human Acute Myeloid Leukemia Cells and Its Association with Adverse Prognosis." Cancers 10, no. 9 (September 14, 2018): 332. http://dx.doi.org/10.3390/cancers10090332.
de Mel, Sanjay, Su Hong Lim, Moon Ley Tung, and Wee-Joo Chng. "Implications of Heterogeneity in Multiple Myeloma." BioMed Research International 2014 (2014): 1–12. http://dx.doi.org/10.1155/2014/232546.
Дисертації з теми "Clonal heterogeneity":
Beer, Philip. "The human myeloproliferative disorders : molecular pathogenesis and clonal heterogeneity." Thesis, University of Cambridge, 2009. https://www.repository.cam.ac.uk/handle/1810/226756.
Nguyen, Long Viet. "Clonal heterogeneity of normal and transformed mammary stem cells." Thesis, University of British Columbia, 2014. http://hdl.handle.net/2429/47023.
Zhao, Boyang. "Rational drug combinations design against intratumoral heterogeneity and clonal evolution." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103271.
Cataloged from PDF version of thesis.
Includes bibliographical references (pages 119-121).
Cancer is a clonal evolutionary process. This results in complex clonal architecture and intratumoral heterogeneity in each patient. This also presents challenges for effective therapeutic intervention - with constant selective pressure to induce or select pre-existing resistant subclones toward drug resistance. Mathematical/computational modeling from population genetics, evolutionary dynamics, and engineering are being utilized to a greater extent in recent times to study tumor progression, intratumoral heterogeneity, drug resistance, and rational drug scheduling/combinations design. In this thesis we present several joint quantitative and experimental approaches for the rational design of drug combinations to tackle the issue of intratumoral heterogeneity and clonal evolution. Using a tractable experimental system with pre-defined tumor compositions, we derived computational approaches to rationally design drug combinations with the goal of minimizing a given heterogeneous tumor. We found that the best drug combinations can oftentimes be non-intuitive as they do not contain component drugs most effective for the individual subpopulations. This was the result of a need for combinatorial considerations on the effects of each drug on all subpopulations, hence at times leading to non-intuitive drug regimens. We validated our computational model predictions in vitro and in vivo in a preclinical model of Burkitt's lymphoma, with predictable evolutionary trajectories upon treatment. Next, we extended this methodology to study the effects of more complex tumor heterogeneity on combinatorial drug design, with similar conclusions. Sampling and statistical analyses over a range of tumor compositions can further inform effective drug combinations under some uncertainty in initial tumor heterogeneity. Moving beyond a model where we have control of initial tumor composition, we sought to examine collateral resistance and sensitivity during clonal evolution. Using a murine model of Ph+ acute lymphoblastic leukemia, we performed drug selection and pharmacological screen experiments. We observed important evolutionary processes of selection and drift in giving rise to resistance to clinically used BCR-ABL1 inhibitors. Remarkably, the resistant population also became hyper-sensitized to nonclassical BCR-ABL1 inhibitors at intermediate stages of the clonal evolution, in this so-called 'temporally collateral sensitivity'. Mathematical modeling and experimentation brought additional insight into the evolutionary dynamics and mechanism of action, with demonstrated in vivo efficacy.
by Boyang Zhao.
Ph. D.
Zucker, Mark Raymond. "Inferring Clonal Heterogeneity in Chronic Lymphocytic Leukemia From High-Throughput Data." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1554049121307262.
Okamoto, Takeshi. "Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells." Kyoto University, 2004. http://hdl.handle.net/2433/147533.
Khattra, Jaswinder. "Charting clonal heterogeneity in breast cancers : from bulk tumor genomes to single-cell genotypes." Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/53485.
Medicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
Lamprecht, Sebastian [Verfasser], and Andreas [Akademischer Betreuer] Jung. "Clonal dynamics and tumor cell heterogeneity in colorectal cancer / Sebastian Lamprecht ; Betreuer: Andreas Jung." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1161670726/34.
Marass, Francesco. "Latent feature models and non-invasive clonal reconstruction." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267784.
Cornils, Kerstin, Lars Thielecke, Doreen Winkelmann, Tim Aranyossy, Mathias Lesche, Andreas Dahl, Ingo Roeder, Boris Fehse, and Ingmar Glauche. "Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230481.
Sikorski, Darek. "Small volume cell culture technology for the analysis of clonal heterogeneity in mammalian cell populations." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61186.
Applied Science, Faculty of
Graduate
Книги з теми "Clonal heterogeneity":
Straus, Lisa Ann. Heterogeneity of function in human CD4-8-T-cell clones from the periphery. [New Haven: s.n.], 1988.
Частини книг з теми "Clonal heterogeneity":
Fanale, Daniele, Juan Lucio Iovanna, Antonio Giordano, Christian Rolfo, and Antonio Russo. "Cancer Clonal Evolution and Intra-tumor Heterogeneity." In Current Clinical Pathology, 27–39. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-55661-1_3.
Berger, Marc G., and Céline Bourgne. "Contribution of Chronic Myeloid Leukaemia (CML) as a Disease Model to Define and Study Clonal Heterogeneity." In Stem Cells Heterogeneity in Cancer, 171–85. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-14366-4_10.
Ahn, Soyeon, and Haiyan Huang. "Multiregion Sequence Analysis to Predict Intratumor Heterogeneity and Clonal Evolution." In Methods in Molecular Biology, 283–96. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1103-6_14.
De Giovanni, Carla, Pier-Luigi Lollini, Brunella Del Re, Giordano Nicoletti, Giorgio Prodi, Katia Scotlandi, and Patrizia Nanni. "Heterogeneity and Clonal Interactions in the TS/A Murine Mammary Adenocarcinoma." In Advances in Experimental Medicine and Biology, 5–14. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4899-5037-6_2.
Scherer, Florian. "Capturing Tumor Heterogeneity and Clonal Evolution by Circulating Tumor DNA Profiling." In Tumor Liquid Biopsies, 213–30. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-26439-0_11.
Aparicio, Pedro, Dolores Jaraquemada, and José A. López de Castro. "Cellular Allorecognition of HLA-B27: Clonal Heterogeneity and Identification of Immunodominant Sites." In Immunobiology of HLA, 112–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-662-39946-0_21.
Geng, Yu, Zhongmeng Zhao, Jing Xu, Ruoyu Liu, Yi Huang, Xuanping Zhang, Xiao Xiao, Maomao, and Jiayin Wang. "Identifying Heterogeneity Patterns of Allelic Imbalance on Germline Variants to Infer Clonal Architecture." In Intelligent Computing Theories and Application, 286–97. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63312-1_26.
Laganà, Alessandro. "Computational Approaches for the Investigation of Intra-tumor Heterogeneity and Clonal Evolution from Bulk Sequencing Data in Precision Oncology Applications." In Advances in Experimental Medicine and Biology, 101–18. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-91836-1_6.
Biddison, William E., and Stephen Shaw. "SB-Specific CTL Clones Exhibit Functional Heterogeneity in their Susceptibility to Blocking by Anti-T3 and Anti-T4 Antibodies." In Human T Cell Clones, 59–69. Totowa, NJ: Humana Press, 1985. http://dx.doi.org/10.1007/978-1-4612-4998-6_6.
Mosmann, T. R., N. E. Street, D. F. Fiorentino, M. W. Bond, T. A. T. Fong, J. Schumacher, J. A. Leverah, M. Trounstine, P. Vieira, and K. W. Moore. "Heterogeneity of Mouse Helper T Cells and Cross-Regulation of TH1 and TH2 Clones." In Progress in Immunology, 611–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-83755-5_82.
Тези доповідей конференцій з теми "Clonal heterogeneity":
Desai, Rhea, Colin Seymour, and Carmel Mothersill. "Clonal heterogeneity and its relevance to the radiosensitivity of tumours." In RAD Conference. RAD Centre, 2022. http://dx.doi.org/10.21175/rad.sum.abstr.book.2022.25.5.
Loeb, Lawrence A., Michael W. Schmitt, Mark J. Prindle, and Pamela S. Becker. "Abstract 4890: Duplex sequencing of AML reveals extensive sub clonal heterogeneity." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-4890.
Laughney, Ashley M., Srinivas Malladi, Danilo Macalinao, and Joan Massagué. "Abstract A01: Investigating clonal heterogeneity and transcriptional vulnerabilities in latent metastasis." In Abstracts: AACR Special Conference on Developmental Biology and Cancer; November 30 - December 3, 2015; Boston, Massachusetts. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3125.devbiolca15-a01.
Xu, Lixia, Minghui He, Zihao Dai, Sui Peng, and Ming Kuang. "IDDF2018-ABS-0097 Genomic heterogeneity and clonal evolution of multifocal hepatocellular carcinoma." In International Digestive Disease Forum (IDDF) 2018, Best Abstracts, Hong Kong, 9–10 June 2018. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-iddfbestabstracts.6.
Bardelli, Alberto. "Abstract CN02-03: Heterogeneity, drug resistance, and clonal dynamics in colorectal cancers." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-cn02-03.
Liao, Yong, David R. Valdecanas, Shangfeng Liu, David Molkintene, Khalida M. Wani, Nalini B. Patel, Li Wang, Chun Dai, Luka Milas, and Walter N. Hittelman. "Abstract 1161: Visualizing lung cancer heterogeneity by color-coding clonal cell subpopulations." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-1161.
Bardelli, Alberto. "Abstract PL04-03: Heterogeneity, drug resistance, and clonal evolution in colorectal cancers." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-pl04-03.
Krook, Melanie A., Russell Bonneville, Hui-Zi Chen, Julie W. Reeser, Michele R. Wing, Jharna Miya, Amy M. Smith, et al. "Abstract 2909: Rapid autopsy of metastatic cholangiocarcinoma demonstrates diverse patterns of clonal heterogeneity." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-2909.
Krook, Melanie A., Russell Bonneville, Hui-Zi Chen, Julie W. Reeser, Michele R. Wing, Jharna Miya, Amy M. Smith, et al. "Abstract 2909: Rapid autopsy of metastatic cholangiocarcinoma demonstrates diverse patterns of clonal heterogeneity." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-2909.
Tshering, Lara F., Fu Luo, Nam D. Nguyen, James G. Rail, Ting Jin, Daifeng Wang, and Flaminia Talos. "Abstract 3126: Intratumor heterogeneity and clonal dynamics underlying treatment resistance in prostate cancer." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-3126.
Звіти організацій з теми "Clonal heterogeneity":
Applebaum, Shalom W., Lawrence I. Gilbert, and Daniel Segal. Biochemical and Molecular Analysis of Juvenile Hormone Synthesis and its Regulation in the Mediterranean Fruit Fly (Ceratitis capitata). United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570564.bard.