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Дисертації з теми "Clozapine"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Fisher, Michael. "Clozapine-induced paroxysmal discharges." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2190.

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The atypical antipsychotic clozapine is a widely prescribed and effective treatment for the positive and negative symptoms of schizophrenia, but reports of side effects are common. In one study EEG abnormalities were observed in 53% of patients treated with clozapine, and the absence or presence of EEG abnormalities correlated with the plasma clozapine concentration. Here, epileptiform activity was present in conventional EEG recordings from a 32 year old male patient with psychiatric illness taking clozapine for 3 weeks. Brief (ca.100ms), transient epileptiform spikes occurred at a frequency

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2

Mourlot-Chabanon, Pascale. "Bilan d'utilisation de la clozapine." Montpellier 1, 1997. http://www.theses.fr/1997MON11031.

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3

DAHER, OSCAR. "Tolerance a la clozapine (leponex*)." Saint-Etienne, 1993. http://www.theses.fr/1993STET6205.

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4

Durão, Ana Maria Sertori. ""Grupo de acompanhamento de pacientes e familiares de portadores de esquizofrenia medicados com clozapina: o impacto sobre o cotidiano de suas vidas"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/22/22131/tde-08092004-165526/.

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Trata-se de uma pesquisa de avaliação, de natureza qualitativa,do tipo descritivo exploratório. Que teve como proposta descrever o cotidiano do portador de esquizofrenia em três momentos: antes do uso da clozapina; após o uso da clozapina; após o uso da mesma e o acompanhamento em grupo. A população foi constituída por todos os portadores de esquizofrenia que participaram do grupo de medicações atípicas (GRUMA) em uso de clozapina e um familiar que os acompanhavam com maior freqüência ao grupo. Para coleta dos dados foram realizadas entrevistas semi-estruturadas, com pacientes e familiares, gu

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5

Wilkes, Susanna Jane Lawson. "An investigation into clozapine induced agranulocytosis." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336629.

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6

Tschen, Alice C. "The in vitro metabolism of clozapine, implications for an in vitro predictive test for clozapine-induced agranulocytosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/MQ28678.pdf.

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7

Hsu, Pei-Chun (Lisa). "Capillary electrophoresis improving clinical measurement of clozapine." Thesis, University of Canterbury. School of Biological Sciences, 2008. http://hdl.handle.net/10092/2260.

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Schizophrenia is a mental disorder affecting approximately one percent of the population worldwide. The introduction of the second generation antipsychotic drug, atypical antipsychotic, clozapine, has demonstrated 80% reduction in suicide incident. This drug showed effectiveness in the treatment of resistant schizophrenia, however, high concentrations of clozapine and N-desmethylclozapine in plasma exhibit the development of agranulocytosis, a possible lethal blood disorder. Therefore, constant therapeutic drug monitoring is important for patients who receive clozapine. High performance liquid

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8

Salmi, Peter. "Clozapine as a dopamine D1 receptor agonist /." Stockolm : Universitet Stockholms, 1998. http://catalogue.bnf.fr/ark:/12148/cb401175060.

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9

Raaska, Kari. "Pharmacokinetic interactions of clozapine in hospitalized patients." Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/raaska/.

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10

Jolivel, Céline. "Etude médico-économique de la clozapine (Leponex (R)), neuroleptique atypique, dans le traitement des schizophrénies résistantes." Bordeaux 2, 1997. http://www.theses.fr/1997BOR2P054.

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11

Souza, Juliano dos Santos. "Eficácia de antipsicóticos atípicos comparados à clozapina em pacientes com esquizofrenia refratária: revisão sistemática e metanálise." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-04112010-160946/.

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INTRODUÇÃO: Considera-se a clozapina como padrão-ouro para o tratamento de pacientes com esquizofrenia refratária, com base principalmente em sua eficácia comprovadamente superior em relação aos antipsicóticos típicos. No entanto, os dados acerca do uso de outros antipsicóticos atípicos ainda são escassos ou divergentes. Tendo em vista que o uso de clozapina está associado a várias limitações, existe uma necessidade não atendida de alternativas terapêuticas eficazes e seguras para a esquizofrenia refratária. MÉTODOS: Foi realizada uma revisão sistemática de estudos controlados e randomizados (

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12

Legge, Sophie E. "Examining treatment response and adverse effects of clozapine." Thesis, Cardiff University, 2015. http://orca.cf.ac.uk/91366/.

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The antipsychotic clozapine is uniquely effective in the management of treatmentresistant schizophrenia (TRS), but its use is limited by its potential to induce agranulocytosis. A substantial proportion of patients discontinue clozapine treatment, which carries a poor prognosis, and only 30-60% of patients with TRS will respond to clozapine. The causes of clozapine-associated agranulocytosis, and of its precursor neutropenia, are largely unknown although genetic factors contribute. To examine the genetic susceptibility to clozapine-associated neutropenia, I conducted a multifaceted genetic ana

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13

Brown, Julia. "Making Health Agency: Clozapine, Schizophrenia, and Personal Power." Phd thesis, Canberra, ACT : The Australian National University, 2018. http://hdl.handle.net/1885/148757.

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This thesis demonstrates how experiences of agency and health persist in spite of confining social and biological circumstances. I take the case of clozapine-treated schizophrenia, where patients are presented with both renewed hope for an independent life at the same time as undertaking an intensive physiological monitoring regimen that prioritises their life in the most immediate sense only. Clozapine patients face a high risk of chronic multi-morbidities that significantly lower their life expectancy, and they are not quite ‘cured’ of their menta

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14

O'Donnell, Charles John Lawrence. "Molecular consequences of drug bioactivation." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269600.

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15

Ginies, Emmanuelle. "Mesure et surveillance de la clozapinémie : vers un dosage thérapeutique de routine." Montpellier 1, 1998. http://www.theses.fr/1998MON11097.

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16

Allender, David Vanelle Jean-Marie. "Actualité de la clozapine dans la prise en charge du patient schizophrène." [S.l.] : [s.n.], 2004. http://theses.univ-nantes.fr/thesemed/SPEallender.pdf.

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17

Taylor, Anita Margaret. "The discriminative stimulus properties of the atypical antipsychotic clozapine." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367204.

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18

Mujanovic, Ajdin. "Physical health outcomes for young people commenced on clozapine." Thesis, Örebro universitet, Institutionen för medicinska vetenskaper, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-73267.

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Abstract BACKGROUND: Psychotic disorders are associated with symptoms such as delusions and hallucinations as well as impaired functioning. Second generation antipsychotic medications are the first line treatment for psychotic disorders, however a proportion of individuals will not respond to the medication. Clozapine is the most effective second generation anti-psychotics, however it is only used as a third line treatment because of serious side-effects. It is associated with metabolic side-effects, which increase the risk of obesity and diabetes mellitus. AIM: Determine the changes in the we

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19

Martin, Francis. "Schizophrénie, résistance et clozapine : étude rétrospective sur le devenir de dix patients." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2M046.

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20

Murphy, Kate. "Clozapine, concomitant medications and consumers: Assessing the accuracy of medication records and the lived experience of people prescribed clozapine under shared care arrangements." Thesis, Griffith University, 2018. http://hdl.handle.net/10072/381000.

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Schizophrenia is a serious long-term mental illness associated with significant morbidity and mortality. Clozapine is the most effective antipsychotic medication for the treatment of schizophrenia, however, due to potentially life-threatening haematological adverse effects, its use is restricted to people who have not responded to an adequate trial of at least two other antipsychotic medications. The high risk of adverse effects, associated mandatory monitoring and prescribing restrictions all mean that clozapine consumers often continue to be managed in a secondary care public mental health (

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21

Mateus, Luiza Silva. "Efeitos in vitro do antipsicótico clozapina sobre a reatividade da aorta torácica de ratos Wistar." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17137/tde-08112018-153716/.

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Introdução: Em pacientes deprimidos, a mortalidade cardíaca devido à doença cardíaca coronária (CHD) é duas vezes maior do que em pacientes coronarianos nãodeprimidos, possivelmente devido à presença de disfunção endotelial. Pode haver uma associação entre a utilização de drogas antipsicóticas e doenças cardiovasculares, que são associadas à disfunção endotelial vasotônica. Os estudos relacionados aos efeitos das drogas antipsicóticas sobre a função endotelial vascular são praticamente inexistentes. Objetivo: Esse estudo foi delineado para avaliar os mecanismos envolvidos na reatividade vascul

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22

Semedo, Agostinho Tavares. "Avaliação da influência dos polimorfismos CYP2C19*2 e CYP2C19*17 na resposta ao tratamento à clozapina na esquizofrenia." Universidade Federal de Goiás, 2017. http://repositorio.bc.ufg.br/tede/handle/tede/6899.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-03-06T14:02:56Z No. of bitstreams: 2 Dissertação - Agostinho Tavares Semedo - 2017.pdf: 2917656 bytes, checksum: 0a4e0b9aac67ef54832262a3818baf13 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-03-06T14:03:17Z (GMT) No. of bitstreams: 2 Dissertação - Agostinho Tavares Semedo - 2017.pdf: 2917656 bytes, checksum: 0a4e0b9aac67ef54832262a3818baf13 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Ma

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23

Sausen, Tiago Rafael. "Desenvolvimento de comprimidos de clozapina obtidos pelo método de compressão direta." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/10879.

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O presente trabalho teve como objetivo o desenvolvimento de formulação para produção de comprimidos contendo 25 mg de clozapina através do método de compressão direta. A clozapina é utilizada no tratamento da psicose e consta na lista do Programa de Medicamentos Distribuídos em Caráter Excepcional do Ministério da Saúde. Para o desenvolvimento proposto, foi utilizado um desenho experimental do tipo desenho composto central a fim de avaliar a influência dos adjuvantes estearato de magnésio e croscarmelose sódica nas características dos comprimidos obtidos a partir de formulações que continham,

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24

Mariet, Yves. "Neuroleptiques classiques et atypiques : utilisation de la clozapine au centre hospitalier Charles Perrens de Bordeaux." Bordeaux 2, 1993. http://www.theses.fr/1993BOR23095.

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25

Heff, Brigitte. "Dosage de la clozapine (Leponex (R)) et de la déméthylclozapine dans le plasma : méthodologie et intérêt dans le suivi thérapeutique de 23 patients." Bordeaux 2, 1998. http://www.theses.fr/1998BOR2P028.

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26

WACQUIER, SOPHIE. "Clozapine - agranulocytose et effets indesirables : etude aux hopitaux universitaires de strasbourg." Strasbourg 1, 1993. http://www.theses.fr/1993STR15054.

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27

Salamanca, Ayda Luz Malaver. "Análise da influência dos polimorfismos 1236C>T, 2677G>T/A E 3435C>T do gene ABCB1 na resposta ao tratamento com clozapina." Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5291.

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Анотація:

Submitted by Erika Demachki (erikademachki@gmail.com) on 2016-03-03T19:34:50Z No. of bitstreams: 2 Dissertação - Ayda Luz Malaver Slamanca - 2015.pdf: 2106945 bytes, checksum: dd89c61b0a1e8fd1299227d7513b4505 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2016-03-03T19:36:16Z (GMT) No. of bitstreams: 2 Dissertação - Ayda Luz Malaver Slamanca - 2015.pdf: 2106945 bytes, checksum: dd89c61b0a1e8fd1299227d7513b4505 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b8

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28

Smith, Judith Anne. "The discriminative stimulus properties of psychotomimetics and antipsychotics." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367805.

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29

Llorca, Pierre-Michel. "Contribution des approches quantitatives et pharmacologiques a l'etude de la schizophrenie resistante (doctorat)." Clermont-Ferrand 1, 2001. http://www.theses.fr/2001CLF1MM23.

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30

Malesieux, Frédéric. "Schizophrénies résistantes et clozapine : étude rétrospective sur 24 malades de l'évolution des symptômes positifs et négatifs au travers des échelles S.A.P.S et S.A.N.S. d'Andreasen; facteurs pronostiques de la réponse au traitement." Bordeaux 2, 1993. http://www.theses.fr/1993BOR2M114.

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31

Wasley, Rachel A. "A longitudinal study : clozapine versus risperidone in the management of chronic schizophrenia /." Title page, contents and abstract only, 1995. http://web4.library.adelaide.edu.au/theses/09ARPS/09arpsw319.pdf.

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32

Matthiasson, Páll. "Dealing with treatment resistance to clozapine : characteristics of treatment response in schizophrenia." Thesis, King's College London (University of London), 2006. https://kclpure.kcl.ac.uk/portal/en/theses/dealing-with-treatment-resistance-to-clozapine--characteristics-of-treatment-response-in-schizophrenia(f43c968b-8789-44e7-9161-3cab811ee429).html.

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Background: Clozapine, the treatment of choice in treatment-resistant schizophrenia, is not effective in up to half of patients. Aims of this thesis were: to verify whether clozapine augmentation with amisulpride, an atypical antipsychotic with preferential affinity at doparninergic D2-like receptors, is clinically effective; to test the prediction that changes in D2-like receptor availability might explain that improvement; to explore clinical and receptor availability characteristics of good clozapine responders. Methods: Study 1: Thirty-three patients with schizophrenia, partially or non-re

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33

AUDY, VERONIQUE. "Clozapine et prise de poids : etude prospective chez quinze patients schizophrenes resistants." Clermont-Ferrand 1, 1994. http://www.theses.fr/1994CLF1M033.

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34

MURSCHEL, ALAIN. "La clozapine : effets indesirables ; etude dans les chs de la region alsace." Strasbourg 1, 1993. http://www.theses.fr/1993STR15084.

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35

Gomes, Felipe Villela. "Tratamento repetido com canabidiol atenua alterações comportamentais e moleculares em um modelo de esquizofrenia baseado no antagonismo dos receptores NMDA." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/17/17133/tde-05012016-224242/.

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Dados pré-clínicos e clínicos indicam que o canabidiol (CBD), um composto não-psicotomimético presente na planta Cannabis sativa, induz efeitos tipo-antipsicóticos. No entanto, poucos estudos em animais de laboratório investigaram as propriedades antipsicóticas do tratamento repetido com CBD. As alterações comportamentais induzidas pelo tratamento repetido com antagonistas dos receptores glutamatérgicos do tipo N-metil-D-aspartato (NMDA) têm sido propostas como um modelo animal de esquizofrenia. Evidências sugerem que uma hipofunção dos receptores NMDA estaria envolvida nos sintomas positivos,

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36

Mongeot, Alexandre. "Synthèse, réactivité et intérêts pharmacologiques de nouvelles imidazo[-x]azines et de nouveaux imidazoles." Strasbourg 1, 2006. http://www.theses.fr/2006STR13254.

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37

Naghmeh, Jabarizadekivi. "A Comparison of the Effect of Omeprazole and Rabeprazole on Clozapine Serum Concentrations." University of Sydney, 2008. http://hdl.handle.net/2123/2471.

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Master of Philosophy<br>Clozapine is a drug of choice for treatment of refractory schizophrenia, which is primarily metabolized by Cytochrome P450 1A2 (CYP1A2). Norclozapine is its main metabolite. There are reports of wide ranging gastrointestinal side effects associated with clozapine therapy, that result in concomitant administration of proton pump inhibitors to treat acid-related disorders. Omeprazole is an established CYP1A2 inducer, while an in vitro study has shown that rabeprazole is much less potent in this regard. There is no available information about the impact of rabeprazole on C

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38

Masellis, Mario. "Pharmacogenetic analysis of serotonin receptors and clinical response to clozapine in schizophrenia patients." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29323.pdf.

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39

Taylor, David Michael. "Pharmacoepidemiological and pharmacokinetic aspects of the use of clozapine and olanzapine - optimising therapy." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404765.

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40

Frimat, Bruno. "Contribution a l'etude du metabolisme de la clozapine : consequences cliniques (doctorat : pharmacie clinique)." Lille 2, 2000. http://www.theses.fr/2000LIL2P260.

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41

Philibin, Scott D. "The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice." VCU Scholars Compass, 2006. http://scholarscompass.vcu.edu/etd/1318.

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Анотація:

Serotonin and α1 adrenergic receptor antagonism may contribute to atypical antipsychotic drug effects. Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic haloperidol fully substitutes for clozapine. The present study demonstrated that the atypical antipsychotics quetiapine, sertindole, zotepine, iloperidone, melperone fully substituted for clozapine but aripiprazole did not. The typical antipsychotics fluphenazine

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42

Naghmeh, Jabarizadekivi. "A Comparison of the Effect of Omeprazole and Rabeprazole on Clozapine Serum Concentrations." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/2471.

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Анотація:

Clozapine is a drug of choice for treatment of refractory schizophrenia, which is primarily metabolized by Cytochrome P450 1A2 (CYP1A2). Norclozapine is its main metabolite. There are reports of wide ranging gastrointestinal side effects associated with clozapine therapy, that result in concomitant administration of proton pump inhibitors to treat acid-related disorders. Omeprazole is an established CYP1A2 inducer, while an in vitro study has shown that rabeprazole is much less potent in this regard. There is no available information about the impact of rabeprazole on CYP1A2 activity in patien

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43

Joly, Florence. "Inhibition de l'hyperlocomotion provoquée par l'amphétamine chez le rat : comparaison du profil d'activité des antipsychotiques typiques à celui des antipsychotiques atypiques." Paris 5, 1995. http://www.theses.fr/1995PA05P081.

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44

Teixeira, Eduardo Henrique 1969. "Clozapina no tratamento da agressividade patológica grave em crianças e adolescentes com transtorno de conduta ou com autismo." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311601.

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Анотація:

Orientador: Paulo Dalgalarrondo<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-20T05:57:37Z (GMT). No. of bitstreams: 1 Teixeira_EduardoHenrique_D.pdf: 18618532 bytes, checksum: 0774e13250c5cbc72b5b26afc4bc65d7 (MD5) Previous issue date: 2012<br>Resumo: Introdução: Comportamento agressivo pode ser a principal manifestação clínica de Transtorno de Conduta (TC) e Autismo e deve ser cuidadosamente manejado na criança e adolescente, considerando os possíveis prejuízos e a evolução para transtornos psiquiátricos graves

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Júnior, Antônio Reis de Sá. "Caracterização dos sintomas obsessivo-compulsivos em pacientes com esquizofrenia em uso de clozapina ou haloperidol." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-29012009-135612/.

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Métodos: Foi utilizado o SCID-IP para o diagnóstico de esquizofrenia e do TOC. Sessenta pacientes responderam às escalas DY-BOCS, Y-BOCS, PANSS e CGI. Os testes Qui-quadrado com correção de Yates, Mann-Whitney U e Kruskal-Wallis foram usados na análise estatística. Resultados: Dentre os sessenta pacientes avaliados, dez (16,7%) apresentavam critérios diagnósticos pelo DSM-IV para esquizofrenia e TOC; treze (21,7%) tinham SOC, mas não TOC e trinta e sete (61,6%) não tinham TOC ou SOC. A prevalência de TOC ou SOC foi semelhante em pacientes tomando clozapina ou haloperidol (40% VS 35%, respectiv

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46

Humbert-Claude, Marie. "Relations histamine-dopamine : implication du récepteur H₃ en neuropsychiatrie." Université Paris XI, 2010. http://www.theses.fr/2010PA114864.

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Des interactions entre le système histaminergique et le système dopaminergique ont été rapportées dans de nombreuses études. Dans un premier travail, nous avons exploré les interactions entre le récepteur histaminergique H₃ et dopaminergique D₂ co-exprimés dans le striatum. Nos résultats suggèrent que ces deux récepteurs n'interagissent pas au travers de leur couplage aux protéines G, mais montrent que leur activation est additive. Dans la schizophrénie, l'hyperhistaminergie qui accompagne l'hyperdopaminergie pourrait donc coopérer avec cette dernière pour générer les symptômes psychotiques. D

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Guitton-Simon, Claire. "Pharmacocinétique de la clozapine et de ses métabolites après administrations réitérées chez le patient schizophrène." Montpellier 1, 2001. http://www.theses.fr/2001MON13506.

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La première partie de notre mémoire est consacrée à l'analyse des données actuellement disponibles sur la pharmacocinétique et la pharmacologie de la clozapine. La deuxième partie concerne la partie analytique de notre travail. Une méthode de dosage de la clozapine et de ses métabolites (norclozapine et clozapine N-oxyde), dans le plasma et les érythrocytes, par chromatographie liquide à haute performance et détection dans l'ultra-violet a été mise au point. La troisième partie de notre travail concerne l' étude pharmacocinétique de la clozapine et de ses métabolites chez le patient schizophrè

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Mortimer, Ann M. "The neuropsychology of chronic severe schizophrenic patients treated with clozapine versus treatment as usual." Thesis, University of Leicester, 2003. http://hdl.handle.net/2381/29435.

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Introduction: The cognitive effects of antipsychotic drugs represent a potential exploratory tool with which to investigate theoretical models of schizophrenia. According to the `levels of explanation' model, the manipulation of cognition of drugs, reflecting prior changes in brain physiology, should result in symptomatic change. Clozapine is superior to other antipsychotic drugs in the treatment of the symptoms of schizophrenia, but there was little support for the proposition that this was because of superior improvements in cognition. This study aimed to investigate this question in severel

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Freitas, Pedro Henrique Batista de. "Refractory Schizophrenia: Prevalence of Metabolic Syndrome and Quality of Life of Patients Using Clozapine." Instituto Nacional de Pesquisas da Amazônia, 2018. http://bdtd.inpa.gov.br/handle/tede/2640.

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Submitted by Repositorio Tarefa (tarefarepositorio@gmail.com) on 2018-10-22T15:29:33Z No. of bitstreams: 2 Esquizofrenia refrataria ELIDA.pdf: 353750 bytes, checksum: 77025ab979b3a5640e89a351a1ff2cef (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made available in DSpace on 2018-10-22T15:29:33Z (GMT). No. of bitstreams: 2 Esquizofrenia refrataria ELIDA.pdf: 353750 bytes, checksum: 77025ab979b3a5640e89a351a1ff2cef (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2018-01-14<br>Fundação de Amparo à Pesquisa do Est

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Freitas, Rosana Ramos de. "Avaliação das dimensões psicopatológicas da esquizofrenia resistente e não resistente ao tratamento: estudo transversal multicêntrico internacional." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-31102018-130536/.

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A Escala das Síndromes Positiva e Negativa (PANSS) é a escala mais amplamente utilizada para a avaliação da gravidade dos sintomas de esquizofrenia. As revisões das análises fatoriais (AFs) da PANSS sugerem que a melhor solução é o modelo de cinco - fatores (em geral os fatores Positivo, Negativo, Desorganização/Cognitivo, Excitação/Hostilidade, Ansiedade/ Depressão). Estudos atuais consideram que seria útil caracterizar a esquizofrenia resistente ao tratamento (ERT) como um subtipo de esquizofrenia, porém não há estudos que comparam adequadamente as dimensões psicopatológicas da PANSS entre p

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