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Дисертації з теми "College Corner"

Автор: Grafiati

Опубліковано: 25 липня 2024

Оновлено: 31 липня 2025

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1

Musselmann, Kurt. "Developing culture conditions to study keratocyte phenotypes in vitro." [Tampa, Fla] : University of South Florida, 2006. http://purl.fcla.edu/usf/dc/et/SFE0001726.

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2

Etheredge, LaTia Shaquan. "The Effect of Growth Factors on the Corneal Stroma Extracellular Matrix Production by Keratocytes." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0003238.

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3

Vrana, Nihal Engin. "Collagen-based Scaffolds For Cornea Tissue Engineering." Master's thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/3/12607540/index.pdf.

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Анотація:

In this study, collagen based scaffolds were prepared for cornea tissue engineering. Three different cell carriers (rat tail collagen foam, insoluble collagen foam and patterned collagen film) were produced using two different collagen sources. Scaffolds were designed to mimic the unique topographical features of the corneal stroma. A novel crosslinking method was developed to achieve constant foam thickness. All scaffolds were tested with the primary cells of the native corneal stroma, human keratocytes. Although both foams promoted cell growth and penetration, rat tail foams were found to be

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4

Ibrahim, Jamal. "Hydroxylysine glycosides of corneal collagen." Thesis, University of Oxford, 1986. http://ora.ox.ac.uk/objects/uuid:2442f75c-6a1c-4575-98b0-a4475a3df1f2.

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Анотація:

These findings are discussed with respect to the possible role of hydroxylysine glycosides in limiting collagen fibril diameter. Comparisons of the amino acid sequences around the seven glycoside sites however gave no clues as to what makes some lysyl residues more susceptible to modification than others. The possible reasons for the high extent of lysyl modification in the cornea are also discussed.

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5

Song, Yihui. "Development of a printable collagen bioink for treatment of corneal disease." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27218.

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Анотація:

Corneal disease is one of the major causes of blindness. Ocular glues are a common initial treatment for corneal wounds but, in some severe cases, cornea transplantation will be required. However, gluing only offers temporary emergency management, and corneal transplantation is limited by donor shortage. Corneal bioengineering potentially offers an alternative pathway to treat severe corneal injuries. The major challenge in corneal bioengineering is balancing the combined requirements of the flexible manufacturing process whilst providing adequate properties to create a customisable artificial

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6

Acun, Aylin. "Construction Of A Collagen-based, Split Thickness Cornea Substitute." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615340/index.pdf.

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Cornea is the transparent outermost layer of the eye. It is a thin (500 &micro<br>m) multilayer tissue which performes around 75% of the total refraction in the eye. It also protects the inner layers against any type of damage. Since it is avascular, the three cellular layers of cornea always need transport of nutrients and other materials in and out of the tissue via diffusion. Any change in shape, transparency or thickness of cornea, or physical damages and infections, may cause serious defects. The conventional methods are satisfactory in the treatment of mild injuries but severe cases requ

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7

Giacomin, Natalia Torres. "Análise da eficácia e segurança do crosslinking corneano em pacientes com ceratocone avançado." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5149/tde-09042018-100655/.

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Анотація:

OBEJTIVOS: Analisar a segurança e eficácia da cirurgia de crosslinking (CXL) de córnea em pacientes com ceratocone em estágios avançados após um seguimento de 4 anos. MÉTODOS: Trata-se de um estudo retrospectivo de pacientes com ceratocone avançado em progressão (Estágio 3 e 4 da classificação de Amsler-Krumeich) que foram submetidos a cirurgia de CXL seguindo o protocolo padrão. Os parâmetros examinados foram acuidade visual com (AVCC) e sem (AVSC) correção, valores ceratométricos (média, plana, curva e apical), paquimetria, e contagem de células endoteliais no préoperatório e após 12, 24 e 4

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8

Ghannad, Mona. "Design and Synthesis of Collagen-binding Anti-microbial Proteins." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/19981.

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Анотація:

The Herpes simplex virus (HSV) is a virus that commonly infects the skin, and mucous membrane of the mouth, genitalia, and the eye. HSV-1 is the strain that is most commonly associated with corneal infections, and it is the most frequent cause of corneal blindness in North America [1]. Currently no cure is available, and many limitations are characterized by the currently available synthetic antiviral drugs, which suggest the need for other potential drug alternatives and delivery strategies. Anti-microbial peptides are naturally occurring peptides that are potent killers of a broad range of m

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9

Lappin, Cory James. "Investigating the Role of Shroom3 in Collagen Regulation and Development of the Corneal Stroma." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1523921114811659.

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10

Hemmavanh, Chinda. "Regulatory Roles of FACIT Collagens XII and XIV in Cornea Stromal and Endothelial Development and Function." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5038.

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Purpose: Corneal transparency depends upon the precise organization of corneal stromal extracellular matrix and corneal endothelial function. Stromal structure and extracellular matrix organization is responsible for proper refraction of light into the eye. The corneal endothelium is responsible for pumping excess fluid out of the cornea, effectively maintaining corneal hydration and thickness. Corneal transplantation is the current form of treatment for corneal endothelial and stromal dystrophies. The mechanisms controlling stromal collagen fibril packing and organization into orthogonal laye

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11

Rajendran, Vijayalakshmi. "Role of mesenchymal stem cells and collagen-based corneal equivalents in restoring corneal graft transparency." Thesis, University of Aberdeen, 2016. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=232053.

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12

CARLSON, ERIC CURTIS. "THE ROLE OF LUMICAN IN THE FORMATION OF BIO-GLASS: TRANSPARENT CORNEA." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1044293658.

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13

ZILLIOX, PATRICIA. "Le chlorure de benzalkonium, agent antimicrobien en ophtalmologie : influence de la longueur de la chaine carbonee sur son efficacite antimicrobienne et sur la toxicite corneenne." Strasbourg 1, 1988. http://www.theses.fr/1988STR15078.

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14

GAUTHIER, LAURENT. "Utilisation d'une colle de fibrine (tissucol) pour traiter les ulceres de cornee perfores et preperfores." Bordeaux 2, 1988. http://www.theses.fr/1988BOR23003.

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15

Kilic, Cemile. "Study Of Patterned, Multilayered, Collagen-based Scaffolds Designed To Serve As A Cornea Stroma." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615389/index.pdf.

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Анотація:

Cornea is the most exterior, avascular and transparent layer of the eye and is about 500 &micro<br>m in thick. It protects the eye from external objects and it is the main optical element of the eye refracting 70 % of the incoming light. After cataract, corneal diseases and wounds are the second leading cause of the blindness that affects more than 4 million people worldwide. For the highly damaged corneas where the corrections with spectacles or contact lenses cannot be achieved, tissue replacement is the only choice, and is done by cornea transplantation or keratoprostheses. However, due to

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16

Harper, Heather. "Solvent Dependent Molecular Mechanics: A Case Study Using Type I Collagen." Scholar Commons, 2014. https://scholarcommons.usf.edu/etd/5035.

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Анотація:

Being the most abundant protein in the body, by mass, type I collagen provides the building blocks for tissues such as bone, extra-cellular matrix, tendons, cornea, etc[1-3]. The ability of a single protein to create structures with such various mechanical properties is not fully understood. Before one can engineer and assemble a complex tissue, such as cornea, the mechanisms underlying the formation and assembly, mechanical properties, and structure must be investigated and quantified. The work presented herein contains an extensive study of Type I collagen from the molecular to the tissue le

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17

Hadley, Julia C. "Glycation of Type I collagen in ocular tissues and tendon." Thesis, Open University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286926.

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18

Beshtawi, Ithar. "The structural and functional effects of corneal collagen cross-linking on human corneal tissue." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/the-structural-and-functional-effects-of-corneal-collagen-crosslinking-on-human-corneal-tissue(12f210fe-82b6-4855-a3ea-c5abd828642d).html.

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Анотація:

The aim of this project was to analyse the cellular and biomechanical changes after collagen cross-linking (CXL) treatment on postmortem eye-banked human corneas using different UVA intensities and repeated treatments, and to explore the effects of standard collagen cross-linking on keratoconic corneal buttons, in-vitro. Preliminary studies were conducted to assess the feasibility of using eye-banked corneas to assess the effects of collagen cross-linking, and the possibility of applying scanning acoustic microscopy (SAM) to measure the speed of sound/elasticity of corneal tissue. Eye-banked h

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19

Parfitt, Geraint. "Proteoglycans as dynamic regulators of the organised collagen fibril architecture in the cornea : an electron tomography study of the mouse corneal stroma." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55104/.

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Анотація:

The cornea is the primary refractive element of the eye and is also fundamental to the protection of the visual system. Collagen is the major constituent of the cornea, where it is organised in a lattice that enables corneal transparency. Proteoglycan macromolecules are thought to regulate the diameter and spatial order of collagen fibrils in the cornea, which are both pre-requisites for corneal transparency, although the mechanisms by which they organise fibrils are not fully elucidated. This investigation examined the morphology, morphometry and organisation of proteoglycans three-dimensiona

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20

Touboul, David. "Apport de l’élastographie par imagerie des ondes de cisaillement pour l’évaluation de la photo-polymerisation du collagène cornéen." Thesis, Bordeaux, 2014. http://www.theses.fr/2014BORD0051/document.

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Анотація:

Le cross-linking du collagène cornéen (CXL) est une cornéoplastie mini-invasive reposant surun concept biomécanique difficile à objectiver physiquement et dont les preuves del’efficacité thérapeutique sont d’interprétation complexe. Les principes, les nuances et lesrésultats du CXL sont colligés dans cette thèse afin de valider l’intérêt du modèleexpérimental choisi pour tester la pertinence de notre travail de recherche sur l’élastographiecornéenne par ondes de cisaillement.Notre cheminement expérimental a abouti au choix du modèle de CXL trans-épithélial (TCXL)assisté par iontophorèse (I-CXL

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21

Tidu, Aurélien. "Synthèse d'une cornée artificielle à base de collagène I." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066472/document.

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Анотація:

L'objectif du projet est la synthèse d'une cornée artificielle biocompatible à base de collagène de type I extrait et purifié à partir de tendons de queues de rats. La synthèse utilise les propriétés mésogènes (cristal-liquides) de la molécule de collagène ainsi qu'une transition sol-gel mimant l'étape de fibrillogenèse qui se déroule in vivo. Des solutions acides de collagène (500 mM en acide acétique) sont dyalisées contre des solutions de diverses concentrations en acide acétique et en acide chlorhydrique puis concentrées jusqu'à 90 mg/mL. Les phases cristal-liquides données par les différe

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22

Ivanova, Ivelina. "Comportement mécanique de console courte en béton armé renforcée ou réparée par collage des matériaux composites." Thesis, Reims, 2013. http://www.theses.fr/2013REIMS033/document.

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Анотація:

Ce travail porte sur l'étude du comportement mécanique d'une console courte en béton armé renforcée par collage de tissus en fibres de carbone et en particulier sur l'influence du nombre de couches de tissus en fibres de carbone, du type du renforcement, de l'orientation des tissus composites, du type de tissus en fibres de carbone. Les résultats montrent que la performance de la console n‘augmente pas linéairement en fonction de l'épaisseur de la plaque composite. Il existe une épaisseur optimale de tissus en fibres de carbone. Dans le cas du renforcement sur les deux faces du béton, il exist

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23

Wang, Lei [Verfasser], and Peter [Akademischer Betreuer] Bruckner. "Specific role of collagen cross-linking enzymes (lysyl oxidase and tissue transglutaminase) in supramolecular organization of matrix in chicken embryonic cornea and tendon / Lei Wang. Betreuer: Peter Bruckner." Münster : Universitäts- und Landesbibliothek der Westfälischen Wilhelms-Universität, 2011. http://d-nb.info/1027018637/34.

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24

Tidu, Aurélien. "Synthèse d'une cornée artificielle à base de collagène I." Electronic Thesis or Diss., Paris 6, 2016. http://www.theses.fr/2016PA066472.

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Анотація:

L'objectif du projet est la synthèse d'une cornée artificielle biocompatible à base de collagène de type I extrait et purifié à partir de tendons de queues de rats. La synthèse utilise les propriétés mésogènes (cristal-liquides) de la molécule de collagène ainsi qu'une transition sol-gel mimant l'étape de fibrillogenèse qui se déroule in vivo. Des solutions acides de collagène (500 mM en acide acétique) sont dyalisées contre des solutions de diverses concentrations en acide acétique et en acide chlorhydrique puis concentrées jusqu'à 90 mg/mL. Les phases cristal-liquides données par les différe

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25

Montezuma, Ronaldo. "Perfil de textura em conserva de carne bovina (Corned Beef) submetida a diferentes tratamentos térmicos e sua relação com a concentração das proteínas dos tecidos muscular e conjuntivo colagenoso /." São José do Rio Preto : [s.n.], 2010. http://hdl.handle.net/11449/90779.

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Анотація:

Orientador: Roger Darros Barbosa<br>Banca: Pedro Fernando Romanelli<br>Banca: Marcos Franke Pinto<br>Resumo: O objetivo desta pesquisa foi determinar o Perfil de Textura (TPA) em formulações comerciais de "carne bovina em conserva" (corned beef) enlatada processada termicamente e avaliar sua relação com os valores de esterilização (F0), com a Concentração da Proteína do Tecido Conjuntivo Colagenoso (CCTP) e com a Concentração da Proteína do Tecido Muscular (MTP). Foram selecionados 14 lotes de produção de corned beef em latas tronco trapezoidais de 340 g correspondentes ao padrão continental C

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26

Ge, Cheng. "Novel technologies for cell culture and tissue engineering." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:ab1014cf-80a4-4675-b607-96dc52c39b17.

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Анотація:

Cell culture has been a fundamental tool for the study of cell biology, tissue engineering, stem cell technology and biotechnology in general. It becomes more and more important to have a well-defined physiochemical microenvironment during cell culture. Conventional cell cultures employ expensive, manually controlled incubation equipment, making it difficult to maximize a cultures yield. Furthermore, previous studies use qualitative methods to assess cell culture proliferation that are inherently inaccurate and labour intensive, thereby increasing the cost of production. In addition, three dim

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27

Montezuma, Ronaldo [UNESP]. "Perfil de textura em conserva de carne bovina (Corned Beef) submetida a diferentes tratamentos térmicos e sua relação com a concentração das proteínas dos tecidos muscular e conjuntivo colagenoso." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/90779.

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Анотація:

Made available in DSpace on 2014-06-11T19:24:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-03-12Bitstream added on 2014-06-13T18:52:40Z : No. of bitstreams: 1 montezuma_r_me_rcla.pdf: 2261471 bytes, checksum: e8de3c70b94bdde4b8cd09e24247eaf2 (MD5)<br>O objetivo desta pesquisa foi determinar o Perfil de Textura (TPA) em formulações comerciais de “carne bovina em conserva” (corned beef) enlatada processada termicamente e avaliar sua relação com os valores de esterilização (F0), com a Concentração da Proteína do Tecido Conjuntivo Colagenoso (CCTP) e com a Concentração da Proteína do

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28

Vase, Ajoy. "The effect of materials preparation on polymer surfaces." Pomona College, 2007. http://ccdl.libraries.claremont.edu/u?/stc,25.

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This work examines the chemical and physical effects of a material treatment process on the biopolymers PEEK, POM-h, POM-c, PTFE and UHMWPE. The polymers are analyzed physically and chemically using atomic force microscopy, profilometry, scanning electron microscopy, optical microscopy, contact angle measurement, FT infra-red spectroscopy and energy dispersive X-ray spectrometry. PEEK is found to be the most suitable polymer and FT Infra-red spectroscopy an informative analytic tool.

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29

Schmeltz, Margaux. "Microscopie de second harmonique résolue en polarisations linéaire et circulaire pour caractériser l'organisation 3D du collagène." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLX074.

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Анотація:

Le collagène est un élément majeur de l'architecture des organes chez les mammifères où il forme diverses structures tridimensionnelles (3D) propres à chaque tissu. La visualisation de cette organisation 3D multi-échelle est cruciale pour comprendre la structuration d'organes tels que la cornée ou la peau et guider l'ingénierie de tissus artificiels, qui doivent être structurés de manière appropriée pour être fonctionnels. L’organisation du collagène est de plus affectée dans de nombreuses pathologies. Caractériser ces désordres tissulaires in situ de manière quantitative constitue ainsi un en

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30

Nazari, Hashemi Parvin Sadat. "Analyse protéomique et propriétés de ré-épithélialisation des membranes amniotiques humaines en vue d'une greffe de la surface oculaire." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMR085/document.

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Анотація:

La greffe de Membrane Amniotique Humaine (MAH) permet la cicatrisation des ulcères pré-perforants de la cornée et de sauver un nombre significatif d'yeux victimes de brûlures chimiques. La MAH est un matériel biologique, son utilisation pour le traitement des maladies de la surface oculaire donne de bons résultats en raison de sa capacité à réduire l'inflammation et promouvoir une épithélialisation rapide. Pour son utilisation en clinique, la MAH doit bien évidemment être stérile, mais aussi facile à transporter du centre préleveur au centre greffeur, et stockable longtemps et facilement. Actu

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31

El, Khoury Yasmina-Mia. "Artificial collagen for cornea repair." Thesis, 2020. http://hdl.handle.net/1866/24519.

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Анотація:

Les patients atteints de cécité cornéenne résultant d'une maladie ou d'une blessure dans de nombreux pays ne seront probablement pas transplantés avec des cornées de donneurs humains en raison d'une grave pénurie mondiale de tissus de donneurs. Cependant, même si des cornées de donneurs étaient disponibles, les patients présentant une inflammation ou une maladie grave ne seraient pas aidés car ils courent un risque élevé de rejet des cornées de donneurs car celles-ci contiennent des cellules allogéniques. Les implants cornéens sans cellules qui ne déclenchent pas de rejet ont été développés co

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32

Reinštein, Merjavá Stanislava. "Fenotypická charakterizace zdravé lidské rohovky a její změny při zadní polymorfní dystrofií rohovky." Doctoral thesis, 2011. http://www.nusl.cz/ntk/nusl-311376.

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Анотація:

Purpose: The aim of this work was to characterize the healthy human cornea and the cornea of patients suffering from posterior polymorphous corneal dystrophy (PPCD) using different antibodies. Despite the fact that PPCD is a very rare disorder, one of the largest groups of PPCD patients in the world comes from the Czech Republic. This offers us the opportunity to investigate the changes on the clinical, cellular and molecular levels. Material and Methods: A collection of 25 control corneas as well as 16 pathological corneas from PPCD patients were used. Epithelial (cytokeratins) and mesothelia

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33

Gonçalves, Diana Filipa Valbom. "Regularização Corneana com Cross- Linking Guiado por Topografia para o Tratamento do Queratocone." Master's thesis, 2020. http://hdl.handle.net/10316/97777.

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Анотація:

Trabalho Final do Mestrado Integrado em Medicina apresentado à Faculdade de Medicina<br>Introdução: O Cross-Linking (CXL) é uma terapêutica em evolução para o tratamento do queratocone em progressão. Os tratamentos convencionais mostraram ser capazes de estabilizar a progressão mas a sua incapacidade de reabilitar a visão é uma insuficiência importante. Com o protocolo clássico, a superfície da córnea é irradiada uniformemente com UVA, independentemente da irregularidade que causa o défice visual. Isto significa que a melhoria refrativa e visual associada aos padrões de CXL é, quando presente,

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34

Sylvestre, Daniel Joseph. "Optimizing riboflavin/ultraviolet-a corneal collagen cross-linking for the treatment of progressive keratoconus." Thesis, 2017. https://hdl.handle.net/2144/23839.

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Анотація:

Patients with keratoconus exhibit a biomechanically weakened cornea which loses its proper shape and thereby loses its refractive power. It is usually progressive, beginning with poor visual acuity and eventually necessitating corneal transplant. The cause is likely multifactorial, but involves the weakening of the collagen structure of the corneal stroma, resulting in characteristic thinning and conical distortion. Collagen cross-linking is the first treatment to demonstrate efficacy in halting the progression of the disease. UVA radiation is used to activate riboflavin and photochemically in

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35

Rowjee, Taruna. "A retrospective analysis of the outcomes in visual acuity and keratometry readings after corneal collagen crosslinking in keratoconus." Thesis, 2017. http://hdl.handle.net/10539/23205.

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Анотація:

A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, in the fulfillment of the requirements for the degree of Master of Medicine in Ophthalmology. Johannesburg, February 2017<br>Purpose: To evaluate if corneal collagen crosslinking carried out on patients with keratoconus, slows down or halts the progression of keratoconus. To determine which group of keratoconus patients benefited most from the procedure. Methods: A retrospective record review of 41 eyes of 29 patients. Visual acuity and keratometry measurements were recorded for the involved eye pre-

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Arabpour, Z., A. Baradaran-Rafii, N. L. Bakhshaiesh, et al. "Design and characterization of biodegradable multi layered electrospun nanofibers for corneal tissue engineering applications." 2019. http://hdl.handle.net/10454/18371.

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Yes<br>Tissue engineering is one of the most promising areas for treatment of various ophthalmic diseases particularly for patients who suffer from limbal stem cell deficiency and this is due to the lack of existence of appropriate matrix for stem cell regeneration. The aim of this research project is to design and fabricate triple layered electrospun nanofibers as a suitable corneal tissue engineering scaffold and the objective is to investigate and perform various in vitro tests to find the most optimum and suitable scaffold for this purpose. Electrospun scaffolds were prepared in three laye

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