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Добірка наукової літератури з теми "COMMON INHIBITOR"

Автор: Grafiati

Опубліковано: 11 вересня 2023

Оновлено: 31 липня 2025

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Статті в журналах з теми "COMMON INHIBITOR"

Arita, Minetaro, Takaji Wakita, and Hiroyuki Shimizu. "Cellular kinase inhibitors that suppress enterovirus replication have a conserved target in viral protein 3A similar to that of enviroxime." Journal of General Virology 90, no. 8 (2009): 1869–79. http://dx.doi.org/10.1099/vir.0.012096-0.

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Previously, we identified a cellular kinase inhibitor, GW5074, that inhibits poliovirus (PV) and enterovirus 71 replication strongly, although its target has remained unknown. To identify the target of GW5074, we searched for cellular kinase inhibitors that have anti-enterovirus activity similar or related to that of GW5074. With this aim, we performed screenings to identify cellular kinase inhibitors that could inhibit PV replication cooperatively with GW5074 or synthetically in the absence of GW5074. We identified MEK1/2 inhibitors (SL327 and U0126), an EGFR inhibitor (AG1478) and a phosphat

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Hopkins, Michael, John J. Tyson, and Béla Novák. "Cell-cycle transitions: a common role for stoichiometric inhibitors." Molecular Biology of the Cell 28, no. 23 (2017): 3437–46. http://dx.doi.org/10.1091/mbc.e17-06-0349.

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The cell division cycle is the process by which eukaryotic cells replicate their chromosomes and partition them to two daughter cells. To maintain the integrity of the genome, proliferating cells must be able to block progression through the division cycle at key transition points (called “checkpoints”) if there have been problems in the replication of the chromosomes or their biorientation on the mitotic spindle. These checkpoints are governed by protein-interaction networks, composed of phase-specific cell-cycle activators and inhibitors. Examples include Cdk1:Clb5 and its inhibitor Sic1 at

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Luan, Hengjie, Mingkang Liu, Qinglin Shan, Yujing Jiang, Peng Yan, and Xiaoyu Du. "Experimental Study on the Effect of Mixed Thermodynamic Inhibitors with Different Concentrations on Natural Gas Hydrate Synthesis." Energies 17, no. 9 (2024): 2078. http://dx.doi.org/10.3390/en17092078.

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Natural gas hydrate (NGH) is a potential future energy resource. More than 90% of NGH resources exist in the pore medium of seafloor sediments. During the development of deep-sea oil and gas fields, wellbore pipelines are often clogged due to the synthesis of gas hydrates, and the addition of thermodynamic inhibitors is a common solution to prevent hydrate synthesis. In this paper, the effects of two single inhibitors, sodium chloride and ethylene glycol, as well as hybrid inhibitors combining these two inhibitors on the synthesis of methane hydrates were investigated using the self-developed

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Watson, R. J., and B. Blackwell. "Purification and characterization of a common soil component which inhibits the polymerase chain reaction." Canadian Journal of Microbiology 46, no. 7 (2000): 633–42. http://dx.doi.org/10.1139/w00-043.

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DNA prepared from soil usually contains a brown-tinted inhibitor of the polymerase chain reaction (PCR) which limits the sensitivity of this technique for specific detection of microorganisms. To localize the inhibitor, soil fractions were tested for their inhibitory effect on the PCR reaction. A highly inhibitory activity, sufficient to account for the inhibition typically exhibited by soil DNA, was found to be tightly associated with the soil microorganism fraction. After cell breakage, the inhibitory material became soluble, and was not separable from DNA by standard purification procedures

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E, Jingwen, Ye Liu, Shanshan Guan, et al. "How Different Substitution Positions of F, Cl Atoms in Benzene Ring of 5-Methylpyrimidine Pyridine Derivatives Affect the Inhibition Ability of EGFRL858R/T790M/C797S Inhibitors: A Molecular Dynamics Simulation Study." Molecules 25, no. 4 (2020): 895. http://dx.doi.org/10.3390/molecules25040895.

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Lung cancer is the most frequent cause of cancer-related deaths worldwide, and mutations in the kinase domain of the epidermal growth factor receptor (EGFR) are a common cause of non-small-cell lung cancers, which is a major subtype of lung cancers. Recently, a series of 5-methylpyrimidine-pyridinone derivatives have been designed and synthesized as novel selective inhibitors of EGFR and EGFR mutants. However, the binding-based inhibition mechanism has not yet been determined. In this study, we carried out molecular dynamic simulations and free-energy calculations for EGFR derivatives to fill

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El-latif, Ashraf Oukasha Abd. "Protease purification and characterization of a serine protease inhibitor from Egyptian varieties of soybean seeds and its efficacy against Spodoptera littoralis." Journal of Plant Protection Research 55, no. 1 (2015): 16–25. http://dx.doi.org/10.1515/jppr-2015-0003.

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Abstract Serine inhibitors have been described in many plant species and are universal throughout the plant kingdom. Trypsin inhibitors are the most common type. In the present study, trypsin and chymotrypsin inhibitory activity was detected in the seed flour extracts of four Egyptian varieties of soybean (Glycine max). The soybean variety, Giza 22, was found to have higher trypsin and chymotrypsin inhibitory potential compared to other tested soybean varieties. For this reason, Giza 22 was selected for further purification studies which used ammonium sulphate fractionation and DEAE-Sephadex A

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Chen, Shanshan, Yutong Xue, Liping Peng, et al. "Research Progress on Types and Mechanism of Common Organic Corrosion Inhibitors." International Journal of Energy 2, no. 3 (2023): 9–12. http://dx.doi.org/10.54097/ije.v2i3.8739.

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In this paper, several kinds of common organic corrosion inhibitors, such as heterocyclic, aldehydes and ketones, organic phosphonic acid, are introduced. The development prospects and application limitations of some corrosion inhibitors are discussed and pointed out. There are also studies have shown that usually two or more corrosion inhibitors are combined or better than a single corrosion inhibitor. Taking the effect as the introduction point, the mechanism of action of organic corrosion inhibitors is generally recognized. Finally, the future research direction of organic corrosion inhibit

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Gao, Xuejun, Dandan Xue, Jingjing Cheng, Xin Zhang, and Xia Cai. "Inhibition of Axl Promotes the Therapeutic Effect of Targeted Inhibition of the PI3K/Akt Pathway in NRAS Mutant Melanoma Cells." Journal of Oncology 2022 (March 11, 2022): 1–9. http://dx.doi.org/10.1155/2022/2946929.

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Melanoma is a malignant tumor produced by highly aggressive and metastatic melanocytes. NRAS mutation is a relatively common mutation in melanoma cells. Mitogen-activated protein kinase (MAPK) signaling pathway and the PI3K/Akt pathway in melanoma cells are relatively common signaling pathways. In this study, we investigated the effect of inhibition of Axl expression on the targeted inhibition of the PI3K/Akt pathway in NRAS-mutant melanoma cells. In this study, immunohistochemistry and western blot methods were used to detect the expression of Axl and Akt proteins in melanoma cells. Axl inhib

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Wei, Jia, Ling Ma, Chenglong Li, Christopher R. Pierson, Jonathan L. Finlay, and Jiayuh Lin. "Targeting Upstream Kinases of STAT3 in Human Medulloblastoma Cells." Current Cancer Drug Targets 19, no. 7 (2019): 571–82. http://dx.doi.org/10.2174/1568009618666181016165604.

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Background:Medulloblastoma is the most common malignant brain tumor in children. Despite improvement in overall survival rate, it still lacks an effective targeted treatment strategy. The Janus family of cytoplasmic tyrosine kinases (JAKs) and Src kinases, upstream protein kinases of signal transducer and activator of transcription 3 (STAT3), play important roles in medulloblastoma pathogenesis and therefore represent potential therapeutic targets.Methods:In this report, we examined the inhibitory efficacy of the JAK1/2 inhibitor, ruxolitinib, the JAK3 inhibitor, tofacitinib and two Src inhibi

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Königs, Christoph, Christoph Kessel, Susanne Stumpf, Janti Roland, Thomas Klingebiel, and Wolfhart Kreuz. "Inhibitor Epitopes Identified from Inhibitor Positive Plasma of a Hemophilia B Patient Change during ITT." Blood 106, no. 11 (2005): 3201. http://dx.doi.org/10.1182/blood.v106.11.3201.3201.

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Abstract Hemophilia B is an X-linked bleeding disorder. Substitution of recombinant (rFIX) or plasma derived (pdFIX) FIX preparations are required to restore coagulation. A rare but severe complication is the development of FIX inhibitors that are often accompanied by allergic reactions. Immune tolerance therapies (ITTs) for inhibitor elimination are difficult and can induce further allergic reactions. ITTs for FIX inhibitors are less established and less successful than for FVIII inhibitors. In this study, three phage displayed random peptide libraries were screened by biopanning to isolate s

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Дисертації з теми "COMMON INHIBITOR"

Hay, Marshall Mark. "Control of Palmer amaranth (Amaranthus palmeri) and common waterhemp (Amaranthus rudis) in double crop soybean and with very long chain fatty acid inhibitor herbicides." Thesis, Kansas State University, 2017. http://hdl.handle.net/2097/35489.

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Master of Science Department of Agronomy Dallas E. Peterson During 2015 and 2016, five site years of research were implemented in double crop soybean after winter wheat at experiment fields in Kansas near Manhattan, Hutchinson, and Ottawa to assess various non-glyphosate herbicide treatments at three different application timings for control of Palmer amaranth (Amaranthus palmeri S. Wats.) and common waterhemp (Amaranthus rudis Sauer). Spring-post (SP) treatments with residual control of Palmer amaranth and waterhemp were applied in the winter wheat at Feekes 4 and resulted in less t

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Rothmayr, Christoph. "Common and distinct neural networks for theory of mind reasoning and inhibitory control." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-124976.

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Pei, Fen, Susanne DiSalvo, Suzanne S. Sindi, and Tricia R. Serio. "A dominant-negative mutant inhibits multiple prion variants through a common mechanism." PUBLIC LIBRARY SCIENCE, 2017. http://hdl.handle.net/10150/626074.

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Prions adopt alternative, self-replicating protein conformations and thereby determine novel phenotypes that are often irreversible. Nevertheless, dominant-negative prion mutants can revert phenotypes associated with some conformations. These observations suggest that, while intervention is possible, distinct inhibitors must be developed to overcome the conformational plasticity of prions. To understand the basis of this specificity, we determined the impact of the G58D mutant of the Sup35 prion on three of its conformational variants, which form amyloids in S. cerevisiae. G58D had been previo

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Isaacs, Mark Allen. "Investigations on the Interations of Acetolactate Synthase (ALS)-Inhibiting Herbicides with Growth Regulator and non ALS-Inhibiting Herbicides in Corn (Zea mays) and Selected Weeds." Diss., Virginia Tech, 2000. http://hdl.handle.net/10919/77970.

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Herbicide combinations are common in corn production in the United States to control broadleaf and grass weed species. Studies were conducted in 1995 and 1996 to: (1) investigate the interactions of 2,4-D and dicamba with halosulfuron-methyl on common lambsquarters and common ragweed control in corn, (2) determine the effect of 2,4-D on the foliar absorption, translocation, and metabolism of 14C halosulfuron-methyl in common lambsquarters, (3) examine the interactions of 2,4-D, dicamba, and ALS-inhibitor herbicides with rimsulfuron plus thifensulfuron-methyl (RT) and with sethoxydim on giant

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Maire, Marie-Aline Vasseur Paule. "Inhibition de l'apoptose comme facteur de la transformation morphologique des cellules embryonnaires de hamster Syrien." Metz : Université Metz, 2008. ftp://ftp.scd.univ-metz.fr/pub/Theses/2004/Maire.Marie_Aline.SMZ0434.pdf.

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Lang, Jean. "Calcium et actions pharmacologiques sur les tissus spécialisé et commun auriculaires." Lyon 1, 1987. http://www.theses.fr/1987LYO1H069.

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Zaffarano, Jennifer I. "MINIMUM INHIBITORY CONCENTRATIONS OF TWO COMMON FOOD PHENOLIC COMPOUNDS AND THEIR EFFECT ON THE MICROBIAL ECOLOGY OF SWINE FECES IN VITRO." UKnowledge, 2003. http://uknowledge.uky.edu/gradschool_theses/182.

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Feeding sub-therapeutic levels of antibiotics to livestock has been associated withdevelopment and spread of antibiotic resistant bacteria. The present experiment was conductedto investigate the effect of antibiotic alternatives (caffeic acid, chlorogenic acid, and carbadox)on the microbial ecology of swine feces in vitro.Minimum inhibitory concentrations of caffeic and chlorogenic acids were determined forseveral pathogens using macrobroth and agar dilution techniques. Gram-negative bacteria werenot inhibited. Caffeic acid inhibited four Staphylococcus aureus strains at 200 ppm or less, andtw

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Zaffarano, Jennifer I. "Minimum inhibitory concentration of two common food phenolic compounds and their effects on the microbial ecology of swine feces in vitro." Lexington, Ky. : [University of Kentucky Libraries], 2003. http://lib.uky.edu/ETD/ukyansc2003t00099/JZThesis.pdf.

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Thesis--University of Kentucky (M.S.), 2003. Title from document title page. Document formatted into pages; contains ix, 127 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 110-126).

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Sekhon, Jaspreet. "Antisense inhibition of methylenetetrahydrofolate reductase as a cancer treatment and a pharmacogenetic study to examine the effects of a common polymorphism." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33029.

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Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in the metabolism of folate and methionine. MTHFR catalyzes the conversion of 5,10 methylenetetrahydrofolate (5,10-methyleneTHF) to 5-methyltetrahydrofolate (5-methylTHF). 5-MethylTHF is a co-substrate for homocysteine remethylation to methionine catalyzed by the vitamin B12-dependent enzyme methionine synthase. A common MTHFR variant, 677C → T substitution resulting in the conversion of an alanine to a valine residue, has been shown to be a thermolabile form of MTHFR and to have reduced activity (Frosst et al., 1995). Sin

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Sköld, Anna-Carin. "Teratogenicity as a consequence of drug-induced embryonic cardiac arrhythmia : Common mechanism for almokalant, sotalol, cisapride, and phenytoin via inhibition of IKr." Doctoral thesis, Uppsala University, Department of Pharmaceutical Biosciences, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-515.

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During the last years, drugs that prolong the repolarisation phase of the myocardial action potential, due to inhibition of the rapid component of the delayed-rectifying potassium channel (IKr) have been in focus. In addition to arrhythmogenic potential, selective Ikr-blockers have also been shown to be embryotoxic and teratogenic in animal studies. The aim of this thesis was to investigate a theory that these developmental toxic results from pharmacologically induced episodes of embryonic cardiac arrhythmias leading to hypoxia related damage in the embryo. Almokalant (ALM) was u

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Книги з теми "COMMON INHIBITOR"

1943-, Greenwald Robert A., Golub Lorne M, and New York Academy of Sciences., eds. Inhibition of matrix metalloproteinases: Therapeutic potential. New York Academy of Sciences, 1994.

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NATO Advanced Research Workshop on Regulation of Extravascular Fibrinolysis in Nervous System Development and Disease (1989 Maratea, Italy). Serine proteases and their serpin inhibitors in the nervous system: Regulation in development and in degenerative and malignant disease. Edited by Festoff Barry W, Hantaï Daniel, and North Atlantic Treaty Organization. Scientific Affairs Division. Plenum Press, 1990.

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Takao, Kumazawa, Kruger Lawrence, and Mizumura Kazue, eds. The polymodal receptor: A gateway to pathological pain. Elsevier, 1996.

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Wang, Qiwei, and Tao Chen. Oilfield Scale Mitigation-From Prediction to Prevention: Tackling Challenges in Energy Transition and Sustainability. AMPP, Association for Materials Protection and Performance15835 Park Ten Place, Houston, TX 77084, 2025. https://doi.org/10.5006/37696.

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Drs. Tao Chen and Qiwei Wang, both AMPP Fellows and industry renown experts in petroleum engineering and oilfield chemistry, have teamed on Oilfield Scale Mitigation: From Prediction to Prevention: Tackling Challenges in Energy Transition and Sustainability. The two SMEs amassed an impressive roster of other well-recognized experts in the field to submit thoroughly researched and vetted original content to make up the 20 chapters the book offers. Organized in four sections-fundamentals, scale inhibitor treatment, exotic scales, and new technologies for sustainable production-this unique 650-pa

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McMahon, Chris G. Ejaculatory disorders. Edited by David John Ralph. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0105.

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Ejaculatory/orgasmic disorders are common male sexual dysfunctions, and include premature ejaculation (PE), inhibited ejaculation, anejaculation, retrograde ejaculation, and anorgasmia.Premature ejaculation management is largely dependent upon aetiology. Life-long PE is best managed with PE pharmacotherapy (selective serotonin re-uptake inhibitor [SSRI] and/or topical anaesthetics). The management of acquired PE is aetiology-specific and may include erectile dysfunction (ED) pharmacotherapy in men with co-morbid ED. Behavioural therapy is indicated when psychogenic or relationship factors are

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Tobon, Amalia Londono, and Hanna E. Stevens. Adolescents with SSRI-Resistant Depression. Edited by Ish P. Bhalla, Rajesh R. Tampi, Vinod H. Srihari, and Michael E. Hochman. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190625085.003.0008.

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This chapter provides a summary of a landmark study in child and adolescent psychiatry addressing the common clinical experience of an adolescent that does not respond to initial antidepressant treatment. Should adolescents with selective serotonin reuptake inhibitor (SSRI) resistant depression be switched to another SSRI or to venlafaxine with or without cognitive behavioral therapy? Starting with that question, it describes the basics of the study, including funding, study locations, who was studied, how many patients, study design, study interventions, follow-up, endpoints, results, and cri

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Biotransformation Potential and Uncoupling Behavior of Common Benzotriazole-Based Corrosion Inhibitors. Storming Media, 2002.

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Jani, Suni, Ryan Herringa, and Derek Hursey. Pharmacologic Treatment of Children with Trauma- and Stressor-Related Disorders. Edited by Frederick J. Stoddard, David M. Benedek, Mohammed R. Milad, and Robert J. Ursano. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190457136.003.0023.

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This chapter reviews the principles of psychopharmacological treatment for trauma and stressor-related disorders in children. It will discuss emerging psychopharmacological treatments and theories of trauma- and stress-related disorders (TSRDs) common to childhood, reactive attachment disorder, and disinhibited social engagement disorder. Although there is limited literature on the role of pharmacotherapy in treating TSRDs in children, it has been recognized that α‎- and β‎-adrenergic blocking agents, novel antipsychotic agents, non-selective serotonin reuptake inhibitor antidepressants such a

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Hopkins, Philip M. Adverse drug reactions in anaesthesia. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0022.

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Adverse drug reactions are implicated in more than 40% of anaesthesia-related deaths. Undoubtedly, many more patients experience morbidity from adverse drug reactions. Widely cited definitions of adverse drug reactions encompass common side-effects but this chapter focuses on those that are unexpected reactions to drugs administered by anaesthetists and that occur at normal drug doses. The chapter includes a comprehensive account of malignant hyperthermia, which remains a major contributor to anaesthesia related to deaths. Malignant hyperthermia is a pharmacogenetic condition triggered by pote

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Preusser, Matthias, Gabriele Schackert, and Brigitta G. Baumert. Metastatic brain tumours. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199651870.003.0019.

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Brain metastasis is a common clinical challenge in cancer patients, particularly those with lung cancer, breast cancer, and melanoma. The prognosis is poor, with median overall survival times measured in months for most patient populations. Established treatments include neurosurgical resection, radiotherapy (including stereotactic radiosurgery and stereotactic radiotherapy, whole-brain radiotherapy, and new radiation techniques), and supportive care measures. Recently, more and more targeted therapies such as EGFR inhibitors, HER2 antagonists, BRAF inhibitors, ALK inhibitors, and immune check

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Частини книг з теми "COMMON INHIBITOR"

Argyropoulos, Vasilike, Stamatis C. Boyatzis, Maria Giannoulaki, Elodie Guilminot, and Aggeliki Zacharopoulou. "Organic Green Corrosion Inhibitors Derived from Natural and/or Biological Sources for Conservation of Metals Cultural Heritage." In Microorganisms in the Deterioration and Preservation of Cultural Heritage. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-69411-1_15.

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AbstractIn the last decade, there has been an increase in research related to green corrosion inhibitors for conservation of metals cultural heritage to help promote sustainable practices in the field that are safe, environmentally friendly, and ecologically acceptable. The most common are organic substances derived either from natural and/or biological sources: plant extracts and oils, amino acids, microorganisms, and biopolymers. The chapter will provide a review of these substances as corrosion inhibitors for metals conservation, by discussing the state-of-the-art research to date, with a s

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Rathmayer, Werner. "Inhibition Through Neurons of the Common Inhibitory Type (CI-Neurons) in Crab Muscles." In Frontiers in Crustacean Neurobiology. Birkhäuser Basel, 1990. http://dx.doi.org/10.1007/978-3-0348-5689-8_31.

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Frankel, Adam, and B. Mark Smithers. "Gastroesophageal Reflux Disease." In Mastering Endo-Laparoscopic and Thoracoscopic Surgery. Springer Nature Singapore, 2022. http://dx.doi.org/10.1007/978-981-19-3755-2_34.

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AbstractGastroesophageal reflux disease (GORD) is defined as troublesome symptoms and/or injury to the oesophageal mucosa consistent with acid exposure [1]. GORD is common, with an age-adjusted global prevalence of 9% but significant variation across the world [2]. The diagnosis can often be made on clinical grounds and is more likely if there is at least a partial response to a proton pump inhibitor (PPI) [3]. Indications for oesophageal testing have been recently updated in international consensus guidelines, which include guidelines where diagnosis is not clearly established [4]. Fundoplica

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Bui, Sarah, Drew Stark, Jie Li, Jianchao Zhang, and Yanzhuang Wang. "Common Markers and Small Molecule Inhibitors in Golgi Studies." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2639-9_27.

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Fraser, Alison, James Davidson, Neil Feasey, and Alyn Jenkins. "Limitations of Common Oilfield Scale Inhibitor Chemistries." In Industrial Water Treatment: New Trends, Challenges & Solutions. NACE International, The Worldwide Corrosion Authority15835 Park Ten Place, Houston, TX 77084, 2017. https://doi.org/10.5006/37628-ch17.

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Abstract. The perennial problem of identifying the “best” scale inhibitor is complicated by the wide diversity of operating conditions found in the field and the variety of available chemistries. To provide some guidance in selecting the proper scale inhibitor, a study was made of several scale inhibitors to map their limitations against common field conditions. Seven scale inhibitors with different active chemistries were identified and assessed to determine their limitations in the following areas: performance against calcite and barite scale, thermal stability (inhibitor performance and phy

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Bora, Jutishna, Sayak Banerjee, Indrani Barman, Sarvesh Rustagi, Richa Mishra, and Sumira Malik. "Apoptosis Defects in Cancer and its Therapeutic Implications." In Promising Cancer Therapeutic Drug Targets: Recent Advancements. BENTHAM SCIENCE PUBLISHERS, 2025. https://doi.org/10.2174/9789815238570125010015.

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Apoptosis is the programmed cell death that regulates the cell survival or cell death balance in animals. Defects in apoptosis can cause cancer or autoimmunity, while enhanced apoptosis may cause degenerative diseases. The apoptotic signals mostly contribute to protecting the genomic integrity whereas defective apoptosis might lead to carcinogenesis. The signals of carcinogenesis alter the central points of the apoptotic pathways, which include the FLICE-inhibitory protein (c-FLIP) and the inhibitor of apoptosis (IAP) proteins. The tumor cells trigger the expression of antiapoptotic proteins s

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Sridharan, Meera, and Rajiv K. Pruthi. "Diagnosis and Management of Acquired Bleeding Disorders." In Mayo Clinic Critical and Neurocritical Care Board Review, 2nd ed., edited by Eelco F. M. Wijdicks, Rodrigo Cartin-Ceba, William D. Freeman, Alice Gallo de Moraes, and Richard A. Oeckler. Oxford University Press, 2025. https://doi.org/10.1093/med/9780197628638.003.0054.

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Abstract Acquired hemophilia (also called autoimmune hemophilia) is the most commonly recognized acquired bleeding disorder due to coagulation factor inhibitors. General care of patients with acquired coagulation factor inhibitors includes the use of immunosuppression to decrease the inhibitor titer and (for patients who are bleeding) the use of hemostatic management (eg, with bypassing agents). The most common acquired bleeding disorder associated with monoclonal proteins is acquired von Willebrand syndrome (aVWS). When aVWS is due to immunoglobulin G monoclonal proteins, intravenous immunogl

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Guttmann, Oliver P., Ronald Binder, Oliver Gämperli, and Andreas Baumbach. "Antithrombotics for Acute and Chronic Coronary Syndromes." In Manual of Cardiovascular Medicine. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198850311.003.0014.

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Thrombus formation involves activation of aggregating platelets as well as the formation of fibrin after activation of the coagulation cascade. Fibrin eventually binds to glycoprotein IIB/IIIA receptors on platelets thereby forming a very solid occlusive clot. There are several molecules interfering with platelet activation: (1) aspirin, which blocks the formation of thromboxane A2; (2) clopidogrel, prasugrel, and ticagrelor which block P2Y12 receptors and their activation by ADP; (3) glycoprotein inhibitors that interfere with glycoprotein IIB/IIIA on platelet

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Brody, David L. "Sexual Dysfunction." In Concussion Care Manual, edited by David L. Brody. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190054793.003.0024.

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In private, ask specifically about sexual dysfunction, and if appropriate, ask the collateral source separately. Assess for depression, severe fatigue or hypersomnia, untreated pain, and alcohol or drug abuse (especially marijuana). Check medications for sexual side effects; serotonin specific reuptake inhibitors are the most common culprits. Test for hormonal imbalances and unrecognized cauda equina or lower spinal cord injury. Consider a trial of a phosphodiesterase type 5 (PDE5) inhibitor, and refer to urology for more advanced options.

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Brody, David L. "Sexual Dysfunction." In Concussion Care Manual. Oxford University Press, 2014. http://dx.doi.org/10.1093/med/9780199383863.003.0023.

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This chapter addresses issues surrounding sexual dysfunction after concussion. Ask the patient specifically about sexual dysfunction in private, and if appropriate ask the collateral source separately. Assess for depression, severe fatigue or hypersomnia, untreated pain, and alcohol or drug abuse (especially marijuana). Check medications for sexual side effects; serotonin specific reuptake inhibitors are the most common culprits. Test for hormonal imbalances and unrecognized cauda equina or lower spinal cord injury. Consider a trial of a PDE5 inhibitor and refer to urology for more advanced op

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Тези доповідей конференцій з теми "COMMON INHIBITOR"

Fraser, Alison, James Davidson, Neil Feasey, and Alyn Jenkins. "Limitations of Common Oilfield Scale Inhibitor Chemistries." In CORROSION 2016. NACE International, 2016. https://doi.org/10.5006/c2016-07617.

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Abstract The perennial problem of identifying the “best” scale inhibitor is complicated by the wide diversity of operating conditions found in the field and the variety of available chemistries. To provide some guidance in selecting the proper scale inhibitor, a study was made of several scale inhibitors to map their limitations against common field conditions. Seven scale inhibitors with different active chemistries were identified and assessed to determine their limitations in the following areas: performance against calcite and barite scale, thermal stability (inhibitor performance and phys

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Kevyn Smith, J., and John L. Przybylinski. "The Effect of Common Brine Constituents on the Efficacy of Halite Precipitation Inhibitors." In CORROSION 2006. NACE International, 2006. https://doi.org/10.5006/c2006-06387.

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Abstract The influences of calcium, magnesium, and zinc ions on the efficacies of inorganic and organic based halite precipitation inhibitors are compared and contrasted. Calcium ion enhances the activity of the inorganic inhibitor and decreases the efficiency of the organic inhibitor. Magnesium has negligible influence on the efficacy of either inhibitor. Zinc, although not commonly found in oilfield brines, has a significant inhibitory influence on its own, but this influence is largely canceled by the presence of the organic or, especially, the inorganic halite inhibitor.

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Tomson, Mason, Amy Kan, Gongmin Fu, and Musaed Al-Thubaiti. "A Molecular Theory of Mineral Scale Inhibition." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04075.

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Abstract Mineral scale inhibitors are used in many industries and are ubiquitous in biological systems. Yet, no molecular theory of inhibition exists that can explain field observations and be used to optimize inhibition. A common source of complication in understanding the mechanism of inhibition is potential for precipitation of metal salts of inhibitors, either calcium or iron and possibly other heavy metals. A new molecular theory of scale inhibition is presented that can be used to explain most empirical observations of inhibition of sparingly soluble minerals such as calcite and divalent

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Ciolkowski, Michal, and Neil Bretherton. "Elucidating the Influence of Calcium Ion Concentration on Corrosion Inhibitor Performance." In CORROSION 2021. AMPP, 2021. https://doi.org/10.5006/c2021-16692.

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ABSTRACT CO2 corrosion is one of the most common problems faced during oil and gas production, although steel pipes offer a long-term economical use in CO2 corrosive environments with the application of carefully selected corrosion inhibitors. Inhibitor efficiency is affected by many variables, including temperature, pressure, flow velocity, pH, and composition of produced water. The impact of brine composition on corrosion inhibitor performance is elucidated in this work; more specifically, the question of whether high salinity or high Ca2+ concentration has a greater impact on corrosion inhi

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Shen, Dong, Kung-Po Chao, and Joseph E. Penkala. "A New Method to Mitigate Halite Deposit by Using Non-Water-Soluble Quaternary Ammonium Corrosion Inhibitor." In CONFERENCE 2024. AMPP, 2024. https://doi.org/10.5006/c2024-20867.

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Abstract Halite scale inhibition is one of the most challenging issues in the industry as oil and gas are produced in a high salinity brine environment. Although currently the best practice in the field for halite scale mitigation is to inject fresh water to dilute the halite scaling brines, it is not practical in locations where a nearby source of good quality fresh water is inadequate. Therefore, many studies have been conducted to investigate the chemistry and performance of halite scale inhibitors. The most common halite inhibitors, such as NTAA (nitrilotriacetamide) and potassium ferrocya

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Gunaltun, Y. M., and T. Chevrot. "Requirements for Inhibition of Localised Corrosion." In CORROSION 1999. NACE International, 1999. https://doi.org/10.5006/c1999-99006.

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Abstract Localised corrosion is the principal cause of line failure when corrosion is internal. As the inhibition is the most common way to control corrosion in wet gas and oil production lines, the inhibitor should be able to control localised corrosion in all cases where it may occur. Therefore, Inhibitor selection philosophy should be based on this approach. Laboratory and field evaluation of corrosion inhibitors showed that some products are almost 100% efficient in preventing localised corrosion if their concentration in the water phase is above a threshold value. The main uncertainty, wh

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Fielder, G. D. "Scale Inhibitor Selection for a High Suspended Solids Produced Water System." In CORROSION 2000. NACE International, 2000. https://doi.org/10.5006/c2000-00105.

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Abstract Historically, calcite scaling downhole and in surface equipment was a common problem on an offshore oil production platform, primarily due to commingling of produced water from high bicarbonate and high calcium zones. As much as 180 ppm scale inhibitor had not controlled scale deposition in production headers, free water knockout (FWKO), water tanks and water lines. In some cases, plugging of power oil pumps was attributed to incompatibility of scale inhibitor with produced water. Over the years, various phosphonates and a phosphate ester had been utilized for scale control without su

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Crossland, Alan, Jose Vera, Alistair Fox, Simon Webster, and Greg Hickey. "Developing a High Reliability Approach to Corrosion Inhibitor Injection Systems." In CORROSION 2010. NACE International, 2010. https://doi.org/10.5006/c2010-10324.

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Abstract As oil and gas exploration and production moves into deeper reservoirs and more challenging environments, higher temperatures, higher pressures and more corrosive environments make corrosion place increased demands on inhibitor availability, with designs based on over 99% availability becoming increasingly common. Maximizing corrosion inhibitor performance is key to reducing risk, preventing failures, extending life and deferring replacement costs. The corrosion inhibitor availability model is commonly used as a measure of the effectiveness and potential viability of inhibition. Recen

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Keller, Michael W., Alyssa H. Hall, Kenneth P. Roberts, et al. "Corrosion Inhibition in Oil/Water Environments." In CORROSION 2015. NACE International, 2015. https://doi.org/10.5006/c2015-05819.

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Abstract The use of corrosion inhibitors in multiphase flow environments consisting of oil/water mixtures is common in a wider variety of industries. Frequently, oil is assumed to reduce uninhibited corrosion rate, which could lead to lower required concentrations of inhibitor to maintain protection. In this paper, results of a study of inhibited corrosion in multiphase flow are presented. These results are obtained from a novel three-cell flow loop (EC3) that is capable of simultaneous, independent measurement of erosion, corrosion, and erosion-corrosion. The efficiency of inhibitor in oil-wa

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Lu, Alex Yi-Tsung, and Zhiwei Yue. "Field Case Study: Impact of Corrosion Inhibitor on Scale Control." In CONFERENCE 2024. AMPP, 2024. https://doi.org/10.5006/c2024-20631.

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Abstract Mineral scale deposition and pipeline corrosion are two of the most common challenges that require chemical treatment in oil wells. Combination products including scale inhibitor (SI), corrosion inhibitor (CI) packages, surfactants, and other chemical additives are well accepted as an integrated solution to flow assurance and asset integrity problems. In this work, a case study in the Permian Basin field demonstrates a certain type of combination product exhibiting lower performance than expected. The raw material interference on the scale inhibitors was investigated and presented wit

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Звіти організацій з теми "COMMON INHIBITOR"

Suriyaphol, Gunnaporn. Study the gene expression of E-cadherin, syndecan1, matrix metalloproteinases-2, -7, -9, -14 and tissue inhibitors of metalloproteinases-1 and -2 in canine oral melanoma. Chulalongkorn University, 2015. https://doi.org/10.58837/chula.res.2015.80.

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The objectives of this study were to 1.) select the suitable reference genes for quantitative real-time polymerse chain reaction in the most common canine oral cancers: oral melanoma (OM) and oral squamous cell carcinoma (OSCC), 2.) study the gene expression of E-cadherin (CDH1), syndecan 1 (SDC1), matrix metalloproteinases-2, -7, -9, -14 (MMP2, MMP7, MMP9, MMP14) and tissue inhibitors of metalloproteinases-1 and -2 (TIMP1, TIMP2) in canine OM at the mRNA level and study the CDH1, SDC1 and Ki-67 protein expression by immunohistochemistry, and 3.) study the association of gene expression and th

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Olszewski, Neil, and David Weiss. Role of Serine/Threonine O-GlcNAc Modifications in Signaling Networks. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7696544.bard.

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Significant evidence suggests that serine/threonine-O-linked N-acetyl glucosamine0-(GlcNAc) modifications play a central role in the regulation of plant signaling networks. Forexample, mutations in SPINDLY,) SPY (an O-GlcNAc transferase,) OGT (promote gibberellin GA) (signal transduction and inhibit cytokinin responses. In addition, mutating both Arabidopsis OGTsSEC (and SPY) causes embryo lethality. The long-term goal of this research is to elucidate the mechanism by which Arabidopsis OGTs regulate signaling networks. This project investigated the mechanisms of O-GlcNAc regulation of cytokini

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Obrien, Ivette Z. Biotransformation Potential and Uncoupling Behavior of Common Benzotriazole-Based Corrosion Inhibitors. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada414450.

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Carger, Elizabeth A., and Erwin J. Tan. Concurrent Anticholinergic and Acetylcholinesterase Inhibitor Drug Use Among Older Adults with Dementia: Commonly Done; Never Advised. AARP Public Policy Institute, 2021. http://dx.doi.org/10.26419/ppi.00137.001.

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Dickman, Martin B., and Oded Yarden. Role of Phosphorylation in Fungal Spore Germination. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568761.bard.

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Spore germination is a common and fundamental event in fungal development and in many instances an essential phase of fungal infection and dissemination. Spore germination is also critical for hyperparasites to function as biocontrol agents as well as in fermentation proceses. Our common objective is to understand the mechanisms which regulated spore germination and identify factors involved in pathogenicity related prepenetration development. Our approach is to exploit the overall similarity among filamentous fungi using both a plant pathogen (Colletotricum trifolii) and a model system that i

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Osathanon, Thanaphum. Gene expression profile of continuous and intermittent compressive stress treated human periodontal ligament cells. Faculty of Dentistry Chulalongkorn University, 2019. https://doi.org/10.58837/chula.res.2019.7.

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Mechanical force regulates periodontal ligament cell (PDL) behavior. However, different force types lead to distinct PDL responses. Here, we report that pretreatment with an intermittent compressive force (ICF), but not a continuous compressive force (CCF), promoted human PDL (hPDL) osteogenic differentiation as determined by osteogenic marker gene expression and mineral deposition in vitro. ICF-induced osterix (OSX) expression was inhibited by cycloheximide and monensin. Although CCF and ICF significantly increased extracellular adenosine triphosphate (ATP) levels, pretreatment with exogenous

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Shoseyov, Oded, Steven A. Weinbaum, Raphael Goren, and Abhaya M. Dandekar. Biological Thinning of Fruit Set by RNAase in Deciduous Fruit Trees. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568110.bard.

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Fruit thinning is a common and necessary practice for commercial fruit production in many deciduous tree fruit species. Fruit thinning in apple may be accomplished with a variety of chemical thinning agents, but the use of these chemicals is a subject of environmental concern. It has been shown recently that RNase enzyme, secreted from the stigma and the style, inhibits pollen germination and pollen tube elongation. In this study we have been able to show that Aspergillus niger B-1 RNase can effectively inhibit peach and apple pollen germination, and tube elongation in-vitro, as well as thin f

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Bliss, Desiree, AJ Troyer, Khalid Lodhi, Zhiping Luo, Sangeetha Balabhadra, and Emily Prisaznik. Qualification of Metallic Ions Recovered from Swabbing Unfired Brass Bullet Casings. Florida International University, 2024. https://doi.org/10.25148/gfjcsr.2024.3.

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The presence of metallic ions has been established to inhibit DNA Taq Polymerase, a key component for the Polymerase Chain Reaction (PCR), making amplification challenging when trying to generate a DNA profile of bullet handler transferred DNA, commonly called touch DNA from the unfired bullet casing surface. The goal of this research is to determine the amount of various bivalent cations such as Copper (Cu+2) and Zinc (Zn+2), which are suspected PCR amplification reaction inhibitors. A known concentration (0.1ng/µL) of liquid standardized human DNA, the total amount (1 ng, 3 ng, and 5 ng) was

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Oh, Ju Sun, Yoo Jin Choo, and Min Cheol Chang. Effect of Selective Serotonin Reuptake Inhibitors on Motor Recovery After Stroke: A Systematic Meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0084.

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Review question / Objective: We conducted a meta-analysis to determine the effectiveness of SSRIs in improving motor outcomes after stroke. Condition being studied: Stroke is a major cause of disability, and motor weakness is one of the most disabling and common complications of stroke. It impairs patients’ ability to perform daily activities independently and deteriorates their quality of life. Selective serotonin reuptake inhibitors (SSRIs) have been reported to have a positive effect on motor recovery after stroke, as well as on the prevention or management of post-stroke depression. In con

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Steele, Dale W., Eduardo L. Caputo, Ghid Kanaan, et al. Diagnosis and Management of Obsessive Compulsive Disorders in Children. Agency for Healthcare Research and Quality (AHRQ), 2024. https://doi.org/10.23970/ahrqepccer276.

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Background. Obsessive compulsive disorder (OCD) is a common, chronic, and impairing psychiatric disorder that often begins in childhood or adolescence. Early identification and treatment of OCD is important to prevent a cascade of developmental disruptions lasting into adulthood. The 2012 American Academy of Child and Adolescent Psychiatry (AACAP) Practice Parameter recommends cognitive behavioral therapy that incorporates exposure and response prevention (ERP) as a first-line treatment for mild-to-moderate OCD in youth and recommends combined treatment with ERP (if feasible) and a selective s

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