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Дисертації з теми "Congenital Cardiovascular Disease"

Автор: Grafiati

Опубліковано: 11 березня 2023

Оновлено: 31 липня 2025

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1

Secchi, F. "CARDIOVASCULAR COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING IN CONGENITAL HEART DISEASE." Doctoral thesis, Università degli Studi di Milano, 2017. http://hdl.handle.net/2434/470146.

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Cardiac magnetic resonance (CMR) is a non-invasive imaging modality highly reliable for studying cardiovascular morphology and function. Cardiac computed tomography (CCT) can give valuable anatomic information on CHD in children but implies radiation exposure, a relevant issue in children and newborns who are more radiosensitive than adult patients and have a longer lifetime to develop stochastic effects from radiation. We contributed to show the possibility to obtain an impressively low ionizing dose reduction in CHD patients also using standard 64-slice CT scanners. Conversely, CMR holds a p

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2

Lawley, Claire Margaret. "Outcomes in structural heart disease in New South Wales, Australia: From paediatrics to pregnancy." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20465.

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Aim To characterise and explore the contemporary outcomes at key points in the life of individuals in New South Wales (NSW), Australia, who have undergone a procedure for structural heart disease. Methods The population with structural heart disease was identified and outcomes at key points in life were evaluated using different methodologies; record linkage, retrospective cohort study and systematic review. Health and education outcomes of children with structural heart disease were evaluated via population-based record-linkage cohort studies. The role of advanced imaging methods in manag

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3

Murakami, Alexandre Noboru. "Impacto da parceria entre banco de dados internacional e centro único de cardiologia e cirurgia cardiovascular pediátrica de referência no Brasil." Faculdade de Medicina de São José do Rio Preto, 2018. http://hdl.handle.net/tede/418.

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Submitted by Suzana Dias (suzana.dias@famerp.br) on 2018-10-18T21:36:00Z No. of bitstreams: 1 AlexandreMurakami_dissert.pdf: 1293818 bytes, checksum: d98c26e3e45ebf6e17599765f2d44e2d (MD5)<br>Made available in DSpace on 2018-10-18T21:36:00Z (GMT). No. of bitstreams: 1 AlexandreMurakami_dissert.pdf: 1293818 bytes, checksum: d98c26e3e45ebf6e17599765f2d44e2d (MD5) Previous issue date: 2018-07-27<br>Developing countries have been dealing with several difficulties concerning congenital heart diseases. Among them is lack of control of results through some specific database. The participation i

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4

Trairatvorakul, Pon. "Cardiovascular Safety of Stimulant Medication in Children with Congenital Heart Disease and Attention Deficit/Hyperactivity Disorder." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1459529300.

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5

Milstone, Zachary J. "Histone Deacetylase 1 and 2 are Essential for Early Cardiac Development." eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1014.

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Congenital heart disease is the most common congenital anomaly, affecting approximately 1% of all live births each year. Although clinical interventions are improving, many affected infants do not survive to adulthood. Congenital cardiac defects originate from disturbances during development, making the study of mammalian cardiogenesis critical to improving outcomes for infants with congenital heart disease. Development of the mammalian heart involves epigenetically-driven specification and commitment of a diverse landscape of cardiac progenitors. Recent studies determined that chromatin modif

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6

Carreira, Vinicius S. "The Aryl Hydrocarbon Receptor Contributions to Cardiovascular Development and Health." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1446547352.

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7

Häcker, Anna-Luisa [Verfasser], Renate [Akademischer Betreuer] Oberhoffer-Fritz, Renate [Gutachter] Oberhoffer-Fritz, and Martin [Gutachter] Klingenspor. "Cardiovascular risk in patients with congenital heart disease / Anna-Luisa Häcker ; Gutachter: Renate Oberhoffer-Fritz, Martin Klingenspor ; Betreuer: Renate Oberhoffer-Fritz." München : Universitätsbibliothek der TU München, 2020. http://d-nb.info/1213026105/34.

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8

Ebrahimi, Pegah. "Patient-specific design of the right ventricle to pulmonary artery conduit via computational analysis." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20381.

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Cardiovascular prostheses are routinely used in surgical procedures to address congenital malformations, for example establishing a pathway from the right ventricle to the pulmonary arteries (RV-PA) in pulmonary atresia and truncus arteriosus. Currently available options are fixed size and have limited durability. Hence, multiple re-operations are required to match the patients’ growth and address structural deterioration of the conduit. Moreover, the pre-set shape of these implants increases the complexity of operation to accommodate patient specific anatomy. The goal of the research group is

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9

Pham, Hoang Minh [Verfasser]. "Cardiovascular Magnetic Resonance Imaging in the Assessment of Myocardial Blood Flow, Viability, and Diffuse Fibrosis in Congenital and Acquired Heart Disease / Hoang Minh Pham." Kiel : Universitätsbibliothek Kiel, 2014. http://d-nb.info/1052893724/34.

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10

McDonald, Cameron. "Investigations in Cardiac Development and Cardiac Regeneration." Thesis, Griffith University, 2009. http://hdl.handle.net/10072/366063.

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Cardiovascular disease and congenital heart disease impose a massive burden on society around the world. From the cost in terms of lost human lives and diminished quality of life, to the financial expense of ongoing medical treatment, the heart’s inability to effectively repair and regenerate itself presents a major challenge for medical research. The research conducted within this thesis hoped to contribute to our knowledge of the molecular pathways of myocardial development, and to explore the potential of olfactory derived stem cells to repopulate insulted myocardium. A combination of molec

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11

Kitajima, Hiroumi D. "In Vitro Fluid Dynamics of Stereolithographic Single Ventricle Congenital Heart Defects From In Vivo Magnetic Resonance Imaging." Diss., Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/25074.

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Background: Single ventricle congenital heart defects with cyanotic mixing between systemic and pulmonary circulations afflict 2 per 1000 live births. Following the atriopulmonary connection proposed by Fontan and Baudet in 1971, the present procedure is the total cavopulmonary connection (TCPC), where the superior vena cava (SVC) and inferior vena cava (IVC) are sutured to the left pulmonary artery (LPA) and right pulmonary artery (RPA). However, surgeon preference dictates the implementation of the extra-cardiac and intra-atrial varieties of the TCPC. Overall efficiency and hemodynamic advan

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12

Deng, Wei. "Sialylation and Cardiomyocyte Complex N -Glycosylation Protect Against Dilated Cardiomyopathy and Heart Failure." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6221.

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Dilated cardiomyopathy (DCM) is the third most common cause of heart failure, often associated with arrhythmias and sudden cardiac death if not controlled. Metabolic and/or environmental factors, such as alcohol abuse, obesity, diabetes and Chagas disease, alter glycoprotein glycosylation, can lead to DCM. Inherited genetic disease, such as the human congenital disorders of glycosylation (CDG), causes multi-system manifestations including DCM. Non-congenital changes in glycosylation are also occurred in humans with and in animal models of DCM and heart failure. However, mechanisms responsible

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13

Varghese, Juliet Jaison. "A Magnetic Resonance Imaging Method to Non-Invasively Measure Blood Oxygen Saturation." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1471622211.

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14

Ceballos, Andres. "A multiscale model of the neonatal circulatory system following Hybrid Norwood palliation." Master's thesis, University of Central Florida, 2011. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/4866.

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A system of 32 first-order differential equations is formulated and solved for the LP model using a fourth-order adaptive Runge-Kutta solver. The output pressure and flow waveforms obtained from the LP model are imposed as boundary conditions on the CFD model. Coupling of the two models is done through an iterative process where the parameters in the LP model are adjusted to match the CFD solution. The CFD model domain is a representative HLHS anatomy of an infant after undergoing the Hybrid Norwood procedure and is comprised of the neo-aorta, pulmonary roots, aortic arch with branching arteri

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15

Toussaint, Marcel. "Histologie myocardique dans la stenose pulmonaire." Paris 6, 1987. http://www.theses.fr/1987PA066029.

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16

Fernandes, Alfredo Manoel da Silva. "Duração da hospitalização e faturamento das despesas hospitalares em portadores de cardiopatia congênita e de cardiopatia isquêmica submetidos à intervenção cirúrgica cardiovascular assistidos no protocolo da via rápida." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/5/5131/tde-21072014-110315/.

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Com o objetivo de avaliar o atendimento dos pacientes submetidos à intervenção cirúrgica cardiovascular no protocolo de atendimento na via rápida (fast track recovery) em relação ao protocolo convencional, foi comparada a movimentação dos pacientes atendidos em ambos os protocolos nas diferentes unidades hospitalares. O estudo foi realizado em hospital público universitário especializado em cardiologia de 400 leitos, de referência terciária para o Sistema Único de Saúde. Foram estudados 175 pacientes, 107 (61%) homens e 68 (39%) mulheres, de idades entre 2 meses a 81 anos, dos quais 107 operad

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17

Bartos, Daniel C. "Mechanistic Basis for Atrial and Ventricular Arrhythmias Caused by KCNQ1 Mutations." UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/8.

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Cardiac arrhythmias are caused by a disruption of the normal initiation or propagation of electrical impulses in the heart. Hundreds of mutations in genes encoding ion channels or ion channel regulatory proteins are linked to congenital arrhythmia syndromes that increase the risk for sudden cardiac death. This dissertation focuses on how mutations in a gene (KCNQ1) that encodes a voltage-gated K+ ion channel (Kv7.1) can disrupt proper channel function and lead to abnormal repolarization of atrial and ventricular cardiomyocytes. In the heart, Kv7.1 coassembles with a regulatory protein to condu

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18

Rocheleau, Jessica Marie. "Effect of KCNE1 and KCNE3 Accessory Subunits on KCNQ1 Potassium Channel Function: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/397.

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The KCNE1 and KCNE3 type I transmembrane-spanning β-subunits assemble with the KCNQ1 voltage-gated K+ channel to afford membrane-embedded complexes with dramatically different properties. Assembly with KCNE1 produces the very slowly activating and deactivating IKs current that shapes the repolarization phase of cardiac action potentials. Genetic mutations in KCNQ1 or KCNE1 that reduce IKs current cause long QT syndrome and predispose affected individuals to potentially fatal cardiac arrhythmias. In contrast, complexes formed between KCNQ1 and KCNE3 produce rapidly activating and mostly voltage

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19

Bas, Tuba. "Co– and Post–Translational N–Linked Glycosylation of Cardiac Potassium Channel Subunits: A Dissertation." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/490.

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KCNE1 (E1) peptide is the founding member of the KCNE family (1-5), which is a class of type I transmembrane ß-subunits. KCNE1 peptides assemble with and modulate the gating, ion conducting properties and pharmacology of a variety of voltage-gated K+ channel a-subunits, including KCNQ1 (Q1). Mutations that interfere with the function of either E1 and/or Q1 and disrupt the assembly and trafficking of KCNE1- KCNQ1 channel complexes give rise to diseases such as Romano-Ward (RW) and Jervell Lange Nielsen Syndrome (JLNS), two different forms of Long QT Syndrome (LQTS). Using enzymatic deglycosylat

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20

Alkhouli, Mohammed A. "The Role of MCTP2 in Health and Disease." Diss., 2021. http://hdl.handle.net/1805/25292.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>MCTP2 (multiple C2 domain transmembrane containing protein 2) encodes a protein with poorly understood roles in lipid metabolism and lipid droplet biogenesis. Genetic studies previously identified variations in MCTP2 in conjunction with left ventricular outflow tract obstructive forms of congenital heart disease (CHD). This dissertation research aimed to delineate the biomedical significance of Mctp2 by investigating its expression and consequences of its genetic deletion in mouse models. Temporal and spatial expression of Mctp2 was

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21

Shibambu, Giyani Patrick. "Ascertainment and outcomes of atrioventricular septal defects in Pietersburg Hospital, Limpopo Province, South Africa." Thesis, 2019. http://hdl.handle.net/10386/3136.

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Thesis (M. Med.(Paediatrics and Child Health)) -- University of Limpopo, 2019<br>Background: Congenital heart disease (CHD) is a significant contributor to Under 5 Mortality rate(U5MR) in Limpopo. Atrioventricular septal defect (AVSD) is the best ascertained lesion in Limpopo and is strongly associated with Down syndrome. Few children from Limpopo with CHD including AVSD access cardiac diagnostic and surgical services. Objectives: The study aimed to enumerate, describe syndromes associated with AVSD and outcomes of children with AVSD at Pietersburg hospital. Methods: This is a Retros

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22

Muzio, Francesco Paolo Lo. "Video Kinematic Evaluation: new insights on the cardiac mechanical function." Doctoral thesis, 2022. http://hdl.handle.net/11562/1069146.

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The cardiac mechanical function plays a critical role in governing and regulating its performance under both normal and pathological conditions. The left ventricle has historically received more attention in both congenital and acquired heart diseases and was considered as the mainstay of normal hemodynamics. However, over the past few decades, there has been increasing recognition of the pivotal role of the right ventricle in determining functional performance status and prognosis in multiple conditions. Nonetheless, the ventricles should not be considered separately as they share the

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23

Alves, Rita Dias Cabrita. "Fully non-invasive pressure drop measurements and post treatment prediction in congenital heart diseases via cardiac magnetic resonance and computer flow dynamics." Master's thesis, 2017. http://hdl.handle.net/10451/31815.

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Tese de mestrado integrado em Engenharia Biomédica e Biofísica, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2017<br>De acordo com os dados de 2017 da Organização Mundial da Saúde, as doenças cardiovasculares são a principal causa de morte a nível mundial. Se estes tipos de doenças não forem diagnosticadas e tratadas atempadamente, podem levar a insuficiências cardíacas ou outras complicações irreversíveis. As duas doenças cardiovasculares congénitas estudadas neste trabalho são a coarctação aórtica (CoA), caracterizada por uma estenose, habitualmente, na zona do arc

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