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Дисертації з теми "Controlled Drug Delivery System"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Zaher, Amir. "Remotely controlled drug delivery systems." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57611.

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Implantable drug delivery is becoming an increasingly important field of research, providing great potential for a wide range of flexible and low cost solutions for localized treatment of chronically debilitating diseases. This dissertation presents work that encompasses several approaches for the remote triggering, powering, and control of micro drug delivery devices and systems, designed with remote-controllability, minimal power requirements, biocompatibility, and the potential for minimally invasive implantation in mind. The control mechanisms used rely on microtechnology, nanotechnology,

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2

Lee, Yan Sim. "The development of controlled-chemotherapy drug delivery system." Thesis, University of Bath, 2009. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.512304.

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The aim of this thesis was to develop biodegradable devices loaded with chemotherapy drug. The system is targeted for advanced ovarian cancer treatment through the intraperitoneal (IP) route of administration. Polylactide-co-glycolide (PLGA) was selected as the model biodegradable polymer to produce drug-loaded microsphere, hollow and solid fibres. Copolymer PLGA with three different lactic:glycolic acids ratios; 50:50, 65:35 and 75:25 were used in order to compare their drug loading capacities and in vitro drug release profiles. Cisplatin, a cytotoxic drug with proven activity against ovarian

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3

Feely, L. C. "Controlled release hydroxypropylmethylcellulose mini-matrices." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373348.

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4

Goettsche, Thorsten [Verfasser], Roland [Akademischer Betreuer] Zengerle, and Gerald A. [Akademischer Betreuer] Urban. "IntelliDrug - controlled, oral drug delivery system as tooth implant." Freiburg : Universität, 2016. http://d-nb.info/1128574195/34.

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5

Chia, Leonard Sze Onn. "Investigating controlled release pulmonary drug delivery systems." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/273209.

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The therapeutic effect of pulmonary drug delivery systems is limited by its rapid clearance from the lungs by robust clearance mechanisms. By controlling the release of drugs, the therapeutic effect of pulmonary drug delivery systems, as well as patient convenience and compliance could be improved by reducing the number of times drugs need to be administered. In this study, two controlled pulmonary drug delivery systems for drugs of different solubilities were investigated and they were characterised for their viability as effective controlled release pulmonary drug delivery systems, particula

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6

Mahaguna, Vorapann. "Investigation of cellulose ether polymers in controlled drug delivery." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3037524.

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7

Babu, Kavitha Mary Vadakkel. "The Development of a Novel Controlled Release Drug Delivery System." The University of Waikato, 2007. http://hdl.handle.net/10289/2590.

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The aim of this research was to formulate, characterise and assess the feasibility of a novel drug delivery system known as the in situ gelling matrix (ISGM) where a hydrophilic polymer is suspended in a non-aqueous solvent that converts into a gel when injected subcutaneously or intramuscularly thus giving a controlled release matrix for a drug. Although the concept has been patented with claims that this kind of drug delivery is achievable in theory for a wide variety of candidate substances, actual formulation studies for making a commercially viable product for this technology are complet

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8

Rodriguez, Lidia Betsabe. "Controlled Release System for Localized and Sustained Drug Delivery Applications." University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365107103.

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9

Zhang, Qilei. "NMR and MRI studies of controlled release drug delivery systems." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610886.

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10

Paulsson, Mattias. "Controlled Release Gel Formulations for Mucosal Drug Delivery." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5173-X/.

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11

Chakrapani, Aravind. "Processing and characterization of polymer microparticles for controlled drug delivery systems." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1164827297.

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12

Glässl, Bianca. "On the importance of drug-polymer interactions in controlled drug delivery systems." Lille 2, 2009. http://www.theses.fr/2009LIL2S026.

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L’objectif de cette thèse était de mieux comprendre le mécanisme d’interaction entre le tartrate de métoprolol et des films de polymethacrylate quaternaire (Eudragit RL et Eudragit RS). Pour des raisons de comparaison, des films contenant soit la base libre du métoprolol soit l’acide tartrique libre ont été préparés. Tout d’abord, les systèmes contenant une quantité variable d’un de ces composés (l’acide libre, la base libre ou le sel) ont été caractérisés à l’état sec par microscopie à lumière polarisée, diffraction des rayons X, analyse enthalpique différentielle et analyse des propriétés mé

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13

Yuksel, Deniz. "The formulation of coevaporates as controlled drug delivery systems." Doctoral thesis, Universite Libre de Bruxelles, 1997. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212131.

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14

Lim, Joseph G. P. "Studies of microparticulates as controlled pulmonary drug delivery systems." Thesis, Cardiff University, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316267.

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15

Che, Rose Laili. "Exploiting nanoscale materials properties for controlled drug delivery systems." Thesis, University of East Anglia, 2013. https://ueaeprints.uea.ac.uk/47950/.

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The main objective of this work was to develop a novel drug delivery system exploiting special opportunities afforded by synthesis of nanoscale materials to be applied inside the colon. It must be robust enough to cope with the adverse conditions in the gastrointestinal tract (GI) and be able to reach and release “on demand” at the colon area at the right time. In this work, an oral capsule formulation with iron oxide nanoparticles (IONs) containing coating was used to transport drug and release drug in the colon. With that in mind, the synthesis of poly (alkylcyanoacrylate) nanocapsules by mi

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16

Do, Anh-Vu Tran. "Controlled drug delivery systems and integration into 3D printing." Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6409.

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Controlled drug delivery systems have been utilized to enhance the therapeutic effects of many current drugs by effectively delivering drugs in a time-dependent and repeatable manner. The ability to control the delivery of drugs, whether through sequential, instantaneous, sustained, delayed and/or enhanced release has the potential to provide effective dosing regimens with enhanced therapeutic effects for a plethora of diseases and injuries. For instance, such systems can enhance anti-tumoral responses or, alternatively, promoting tissue regeneration. The current need for organ and tissue repl

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17

THACKER, JAMES H. "SONOFLUIDIC MICRO-SYSTEMS FOR PRECISION-CONTROLLED IN-VIVO DRUG DELIVERY." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1196178160.

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18

Mawad, Damia Graduate School of Biomedical Engineering Faculty of Engineering UNSW. "Development of Novel hydrogels for protein drug delivery." Awarded by:University of New South Wales. Graduate School of Biomedical Engineering, 2005. http://handle.unsw.edu.au/1959.4/25221.

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Introduction: Embolic agents are used to block blood flow of hypervascular tumours, ultimately resulting in target tissue necrosis. However, this therapy is limited by the formation of new blood vessels within the tumour, a process known as angiogenesis. Targeting angiogenesis led to the discovery of anti-angiogenic factors, large molecular weight proteins that can block the angiogenic process. The aim of this research is development of poly (vinyl alcohol) (PVA) aqueous solutions that cross-link in situ to form a hydrogel that functions as an embolic agent for delivery of macromolecular drugs

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19

Chen, Y. Y. "Quantitative fast MRI studies of controlled release drug delivery systems." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597550.

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The thesis describes the development and use of ultra-fast MRI techniques to quantitatively characterise the dissolution process of controlled drug release dosage forms. Implementations and validations of two quantitative single shot RARE based magnetic resonance imaging (MRI) protocols are described. Quantitative <i>T</i><sub>2</sub> (spin-spin relaxation time constant) and diffusion weighted single shot RARE images, both with acquisition time of less than 3 minutes, were achieved by preconditioning the standard RARE sequence with a hard pulse CPMG echo train or an alternating phase bipolar p

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20

Nolan, Christine Marie. "Microgel Based Materials for Controlled Macromolecule Delivery." Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/6874.

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This dissertation focuses on utilization of poly(N-isopropylacylamide) (pNIPAm) based mirogels for regulated macromolecule drug delivery applications. There is particular emphasis on incorporation of stimuli responsive materials into multi-layer thin film constructs with the main goal being fabrication of highly functional materials with tunable release characteristics. Chapter 1 gives a broad overview of hydrogel and microgel materials focusing on fundamental properties of pNIPAm derived materials. Chapter 2 illustrates the progression of controlled macromolecule release from hydrogel and mic

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21

Zhuk, Mikalai. "Nanostructured granules for controlled delivery of dexamethasone." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14181.

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Mestrado em Ciência e Engenharia de Materiais<br>A Drug Delivery System (DDS) may provide the precise transportation of the medical drug inside the patient’s body, directly to the pathological area or alternatively it may be also locally administrated. Once at the site of interest, the ideal DDS is expected to release the drug in a sustained manner according to the specific needs of the patient. As compared to other routes of drug administration, an appropriately designed DDS which active components are conveniently targeted should also ensure the desired in situ treatment without harmful effe

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22

Swami, Salesh N., University of Western Sydney, of Science Technology and Environment College, and of Science Food and Horticulture School. "Radiation synthesis of polymeric hydrogels for swelling-controlled drug release studies." THESIS_CSTE_SFH_Swami_S.xml, 2004. http://handle.uws.edu.au:8081/1959.7/698.

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Hydrogels are three dimensional networks of hydrophilic homopolymers or copolymers generally covalently or ionically crosslinked. They interact with aqueous media by swelling to some equilibrium value by retaining the aqueous media in their structures. This study concerns the investigation of the swelling and the controlled drug release behaviour of hydrogels synthesized via the photopolymerisation process. The study of hydrogels in this project was oriented towards their biomedical applications as controlled drug delivery devices. It is a known fact that the complete conversion of monomers to

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23

Samaligy, Samar el [Verfasser]. "Floating Systems for Oral Controlled Release Drug Delivery / Samar El Samaligy." Berlin : Freie Universität Berlin, 2010. http://d-nb.info/1024784614/34.

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24

Santos, Lúcia Isabel Ferreira. "Physical supports for immobilization of drug particles or controlled drug delivery systems by bioinspired pollination." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22604.

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Mestrado em Biotecnologia Industrial e Ambiental<br>Nos últimos anos, a administração transdérmica de fármacos foi aponte como uma via de libertação de fármacos de sucesso devido às suas enumeras vantagens. Relativamente aos sistemas convencionais, este é um sistema não doloroso, apresenta menos efeitos secundários e possibilita uma dose menos frequente. Os pensos representam a maior quota do mercado de sistemas de libertação transdérmica de fármaco. No entanto, a sua aplicação tem sido restringida pelos atuais problemas associados à sua administração passiva. Com base no conceito de bi

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25

Sharma, Divya. "Drug Delivery Systems for Treatment of Diabetes Mellitus." Diss., North Dakota State University, 2019. https://hdl.handle.net/10365/31745.

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Daily injections for basal insulin therapy are far from ideal resulting in hypo/hyperglycemic episodes associated with fatal complications in type-1 diabetes patients. The purpose of this study was to develop a thermosensitive copolymer-based in situ depot forming delivery system to provide controlled release of insulin for extended duration following a single subcutaneous injection, closely mimicking physiological basal insulin requirement. Size and nature of the incorporated therapeutic were observed to affect the release profile of insulin. Modification with zinc and chitosan preserved ther

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26

Özgarip, Yarkın Bayraktar Oğuz. "Application of Silk Fibroin In Controlled-Release of Theophylline/." [s.l.]: [s.n.], 2004. http://library.iyte.edu.tr/tezler/master/kimyamuh/T000433.pdf.

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27

Swami, Salesh N. "Radiation synthesis of polymeric hydrogels for swelling-controlled drug release studies." Thesis, View thesis, 2004. http://handle.uws.edu.au:8081/1959.7/698.

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Hydrogels are three dimensional networks of hydrophilic homopolymers or copolymers generally covalently or ionically crosslinked. They interact with aqueous media by swelling to some equilibrium value by retaining the aqueous media in their structures. This study concerns the investigation of the swelling and the controlled drug release behaviour of hydrogels synthesized via the photopolymerisation process. The study of hydrogels in this project was oriented towards their biomedical applications as controlled drug delivery devices. It is a known fact that the complete conversion of monomers to

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28

Gates, Kimberly Ann. "Controlled drug delivery using bioerodible polymeric systems for the treatment of periodontitis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq41022.pdf.

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29

Lockwood, Peter John. "The development and characterisation of directly-compressible oral controlled drug delivery systems." Thesis, University of Bath, 1990. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760612.

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30

Chigwanda, Tapuwa Rosemary Jabulani. "The investigation of a hydrophobic matrix for oral controlled drug delivery systems." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307118.

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31

Zern, Blaine Joseph. "A biocompatible, heparin-binding polycation for the controlled delivery of growth factors." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/28145.

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Thesis (M. S.)--Biomedical Engineering, Georgia Institute of Technology, 2009.<br>Committee Chair: Wang, Yadong; Committee Member: Barker, Thomas; Committee Member: Boyan, Barbara; Committee Member: Chaikof, Elliot; Committee Member: Meredith, J. Carson; Committee Member: Prausnitz, Mark.

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32

De, la Torre Paredes Cristina. "Nanotechnology and supramolecular chemistry in controlled release and molecular recognition proceses for biomedical applications"." Doctoral thesis, Universitat Politècnica de València, 2018. http://hdl.handle.net/10251/94043.

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La presente tesis doctoral, titulada "Nanotecnología y química supramolecular en procesos de liberación controlada y reconocimiento molecular para aplicaciones biomédicas", se centra en dos temas importantes: el reconocimiento molecular y los procesos de liberación controlada. Esta tesis doctoral está estructurada en cuatro capítulos. El primer capítulo introduce el concepto de materiales híbridos orgánicos-inorgánicos funcionalizados con puertas moleculares y sus aplicaciones biomédicas como nanomateriales para dirigir y controlar la liberación controlada de fármacos. Además se introduce

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33

Krishnan, Aadithya. "SIMVASTATIN INCORPORATED PERIVASCULAR POLYMERIC CONTROLLED DRUG DELIVERY SYSTEM FOR THE INHIBITION OF VASCULAR WALL INTIMAL HYPERPLASIA." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1186425531.

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34

Giménez, Morales Cristina. "Design of new bio-gated nanodevices for advanced communication processes and targeted controlled release of therapeutic agents." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/62822.

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[EN] The present PhD thesis, which is entitled "Design of new bio-gated nanodevices for advanced communication processes and targeted controlled release of therapeutic agents" is focused on the development of new functional hybrid organic-inorganic materials for applications in the field of the controlled delivery of target molecules. The first chapter of the present thesis gives an introduction to the organic-inorganic hybrid materials functionalized with "molecular gates" and its application in controlled release processes. The second chapter of this thesis is focused on the development of

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35

Krenzlin, Stefanie [Verfasser]. "Challenging controlled drug delivery : matrix systems for oral and parenteral application / Stefanie Krenzlin." Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1027816118/34.

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36

Apichatwatana, Nutsawadee [Verfasser]. "Hot melt extrusion for the production of controlled drug delivery systems / Nutsawadee Apichatwatana." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1026069645/34.

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37

Tait, C. J. "A study of the properties of a poly(oxyethylene)-poly(oxypropylene)- poly(oxyethylene) block copolymer as a controlled release drug delivery system." Thesis, University of Manchester, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379172.

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38

Swami, Salesh N. "Radiation synthesis of polymeric hydrogels for swelling-controlled drug release studies." View thesis, 2004. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20050729.124150/index.html.

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39

O'Connor, Carol Anne. "A study of the gelation of a poly(oxyethylene)-poly(oxypropylene) block copolymer and its potential use for the controlled delivery of drugs." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252724.

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40

Velghe, Carine. "Oral controlled drug delivery systems, optimization of release patterns and elucidation of release mechanisms." Thesis, Lille 2, 2013. http://www.theses.fr/2013LIL2S048/document.

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Le développement de nouvelles formes galéniques nécessite la mise au point de protocoles avec variation d’un ensemble de paramètres jouant sur les caractéristiques du dispositif. Au niveau industriel, cela représente une perte importante de temps et d’argent. Avec le développement d’outils permettant la caractérisation des systèmes et à fortiori des mécanismes impliqués dans la libération du principe actif, l’application des modèles mathématiques se voit être de plus en plus grande permettant de prédire la sortie du principe actif hors de son système. L’un des objectifs de ce travail a été de

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41

Rodríguez, Escalona Gabriela de Jesús. "DEVELOPMENT OF CONTROLLED DRUG DELIVERY SYSTEMS OF POLYMERIC NANOMEDICINES ASSOCIATED TO SCAFFOLDS FOR TISSUE REGENERATION." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/63231.

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[EN] Nowadays, one of the biggest concerns that permanently keep the attention of main important sectors of human society is health. Modern medical science is compromised with not only providing good adequate treatments but also effective specific solutions for each type of disease or human pathology. In this direction, innovative approaches like tissue engineering or regenerative medicine, controlled drug delivery systems and nanomedicines emerge to bring alternatives to situations hard to solve with conventional treatment and strategies, including the replacement of damaged or diseases tissu

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42

Liu, Quan. "Development of a novel gastro-retentive delivery system using alfuzosin HCl as a model drug." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/80170.

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Pharmaceutics;<br>Ph.D.<br>The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gast

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43

Bonzi, Gwénaëlle A. M. "Novel polysaccharide anti-tumour drug delivery system for active targeting and controlled release to breast cancer bone metastases." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423664.

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ABSTRACT In the late stage of the disease, breast cancer patients often develop bone metastases, a major cause of cancer-related death among women worldwide. The common treatment currently used clinically includes the anti-neoplastic agent paclitaxel combined with the bisphosphonate alendronate. Paclitaxel is an anti-neoplastic drug which cytotoxic effect is mainly attributed to its ability to promote the assembly of microtubules as well as prevent the depolymerisation of these microtubules. Stabilization of the microtubule networks stops mitotic functions that, in sequence, blocks cell div

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44

BOI, STEFANIA. "Design and fabrication of polymeric nanoengineered delivery systems for improved performance and controlled release." Doctoral thesis, Università degli studi di Genova, 2021. http://hdl.handle.net/11567/1047611.

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Drug delivery is an increasingly investigated field, aiming at distributing a therapeutic substance precisely to the area, tissue or cell where needed and consequently controlling its release, thus guaranteeing optimal efficiency. Besides, this targeted action can also bring significant advantages in other diverse sectors. The delivery systems designed and fabricated in this work were meant to overcome some of the issues related to current therapies for different illnesses. Specifically, polylactic acid (PLA) was exploited to produce nanoparticles which were functionalized and encapsulated i

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45

Kim, Chi Won. "Synthesis of Porous Coordination Polymers for Controlled Nitric Oxide Release." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/204585.

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46

Kanjickal, Deenu George. "Perivascular Drug Delivery Systems for the Inhibition of Intimal Hyperplasia." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1133715441.

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47

Ma, Jia. "Processing of polymer-based systems for improved performance and controlled release." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/15048.

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This thesis focuses on improved processing methods for enhanced mechanical properties in polymer nanocomposites, and controlled drug release in polymer based delivery systems. Supercritical carbon dioxide assisted mixing was successfully used in preparation of polypropylene/sepiolite and polypropylene/multiwall carbon nanotube nanocomposites. Relatively homogeneous dispersed and well separated nanofillers were obtained throughout the PP matrix. A better preservation of nanofiller lengths was observed in the scCO 2 assisted mixing. Mechanical property studies showed a marked increase in Young's

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Chen, Chen. "Quantitative magnetic resonance imaging studies of extended drug release systems." Thesis, University of Cambridge, 2014. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708155.

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49

Saito, Takashi. "DESIGN AND CHARACTERIZATION OF GELATIN HYDROGELS INCORPORATING LOW-MOLECULAR-WEIGHT DRUGS FOR TISSUE REGENERATION." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199334.

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50

Doiron, Annie. "Radiosensitization of a mouse tumor model (RIF-1) by bromodeoxyuridine (BrdU) using biodegradable polymer implants as a controlled drug delivery system." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape10/PQDD_0001/MQ44160.pdf.

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